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Individual brains vary greatly in morphology, connectivity and organization. The applicability of group-level parcellations is limited by the rapid development of precision medicine today because they do not take into account the variation of parcels at the individual level. Accurate mapping of brain functional regions at the individual level is pivotal for a comprehensive understanding of the variations in brain function and behaviors, early and precise identification of brain abnormalities, as well as personalized treatments for neuropsychiatric disorders. With the development of neuroimaging and machine learning techniques, studies on individual brain parcellation are booming. In this paper, we offer an overview of recent advances in the methodologies of individual brain parcellation, including optimization- and learning-based methods. Comprehensive evaluation metrics to validate individual brain mapping have been introduced. We also review the studies of how individual brain mapping promotes neuroscience research and clinical medicine. Finally, we summarize the major challenges and important future directions of individualized brain parcellation. Collectively, we intend to offer a thorough overview of individual brain parcellation methods, validations, and applications, along with highlighting the current challenges that call for an urgent demand for integrated platforms that integrate datasets, methods, and validations., Comment: 15 pages, 2 figures

Neutrinos from the cosmos have proven to be ideal for probing the nature of space-time. Previous studies on high-energy events of IceCube suggested that some of these events might be gamma-ray burst neutrinos, with their speeds varying linearly with their energy, implying also the coexistence of subluminal and superluminal propagation. However, a recent reanalysis of the data, incorporating revised directional information, reveals stronger signals that neutrinos are actually being slowed down compared to previous suggestion of neutrino speed variation. Thus, it is worth discussing its implications for the brane/string inspired framework of space-time foam, which has been used to explain previous observations. We revisit effects on neutrino propagation from specific foam models within the framework, indicating that the implied violation of Lorentz invariance could necessarily cause the neutrino to decelerate. We therefore argue that this sort of model is in agreement with the updated phenomenological indication just mentioned. An extended analysis of the revised IceCube data will further test these observations and stringy quantum gravity., Comment: 15 latex pages, no figure, final version for publication

Previous studies on high-energy gamma-ray burst neutrinos from IceCube suggest a neutrino speed variation at the Lorentz violation~(LV) scale of $\sim 6.4\times 10^{17}$~GeV, with opposite velocity variances between neutrinos and antineutrinos. Within a space-time foam model, inspired by string theory, we develop an approach to describe the suggested neutrino/antineutrino propagation properties with both Lorentz invariance and CPT symmetry breaking. A threshold analysis on the bremsstrahlung of electron-positron pair~($\nu\rightarrow\nu ee^{+}$) for the superluminal~(anti)neutrino is performed. We find that, due to the energy violation caused by the quantum foam, such reaction may be restricted to occur at sufficient high energies and could even be kinematically forbidden. Constraints on neutrino LV from vacuum $ee^{+}$ pair emission are naturally avoided. Future experiments are appealed to test further the CPT violation of cosmic neutrinos and/or neutrino superluminality., Comment: 23 latex pages, final version for journal publication

We show that the space-time foam model from string/D-brane theory predicts a scenario in which neutrinos can possess linearly energy dependent speed variation, together with an asymmetry between neutrinos and antineutrinos, indicating the possibility of Lorentz and CPT symmetry violation for neutrinos. Such scenario is supported by a phenomenological conjecture from the possible associations of IceCube ultrahigh-energy neutrino events with the gamma-ray bursts. It is also consistent with the constraints set by the energy-losing decay channels~(e.g., $e^{+}e^{-}$ pair emission, or neutrino splitting) upon superluminal neutrino velocities. We argue that the plausible violations of energy-momentum conservation during decay may be responsible for the stable propagation of these neutrinos, and hence for the evasion of relevant constraints., Comment: 5 latex pages, final version for journal publication

The Large High Altitude Air Shower Observatory~(LHAASO) recently reported the detection of gamma-ray emissions with energies up to $1.1~\textrm{PeV}$ from the Crab Nebula. Using the absence of vacuum Cherenkov effect by inverse-Compton electrons, we improve previous bounds to linear-order Lorentz invariance violation (LV) in the dispersion relations of electrons by $10^{4}$ times. We show that the LV effect on electrons is severely constrained, compatible with certain type of LV as expected by some models of quantum gravity~(QG), such as the string/D-brane inspired space-time foam. We argue that such models are supported by the Crab Nebula constraints from the LHAASO observations, as well as various LV phenomenologies for photons to date., Comment: 6 latex pages, 1 figures, final version for publication

Ultrahigh-energy photons up to 1.4 peta-electronvolts have been observed by new cosmic-ray telescope in China -- a hint that Lorentz invariance might break down at the Planck-scale level., Comment: 3 pages, 1 figure, final version for publication

Recently a series of studies on high energy gamma-ray burst~(GRB) photons suggest a light speed variation with linear energy dependence at the Lorentz violation scale of $3.6 \times 10^{17}~\mathrm{GeV}$, with subluminal propagation of high energy photons in cosmological space. We propose stringy space-time foam as a possible interpretation for this light speed variation. In such a string-inspired scenario, bosonic photon open-string travels \textit{in vacuo} at an infraluminal speed with an energy dependence suppressed by a single power of the string mass scale, due to the foamy structure of space-time at small scales, as described by D-brane objects in string theory. We present a derivation of this deformed propagation speed of the photon field in the infrared (IR) regime. We show that the light speed variation, revealed in the previous studies on GRBs time-delay data, can be well described within such a string approach towards space-time foam. We also derive the value of the effective quantum-gravity mass in this framework, and give a qualitative study on the theory-dependent coefficients. We comment that stringent constraints on Lorentz violation in the photon sector from complementary astrophysical observations can also be explained and understood in the space-time foam context., Comment: 10 latex pages, no figure, final version for publication

The Large High Altitude Air Shower Observatory~(LHAASO) is one of the most sensitive gamma-ray detector arrays currently operating at TeV and PeV energies. Recently the LHAASO experiment detected ultra-high-energy~(UHE; $E_{\gamma}\gtrsim 100~\mathrm{TeV}$) photon emissions up to $1.4~\mathrm{PeV}$ from twelve astrophysical gamma-ray sources. We point out that the detection of cosmic photons at such energies can constrain the photon self-decay motivated by superluminal Lorentz symmetry violation~(LV) to a higher level, thus can put strong constraints to certain LV frameworks. Meanwhile, we suggest that the current observation of the PeV-scale photon with LHAASO may provide hints to permit a subluminal type of Lorentz violation in the proximity of the Planckian regime, and may be compatible with the light speed variation at the scale of $3.6\times 10^{17}~\mathrm{GeV}$ recently suggested from gamma-ray burst~(GRB) time delays. We further propose detecting PeV photons coming from extragalactic sources with future experiments, based on LV-induced threshold anomalies of $e^{+}e^{-}$ pair-production, as a crucial test of subluminal Lorentz violation. We comment that these observations are consistent with a D-brane/string-inspired quantum-gravity framework, the space-time foam model., Comment: 7 latex pages, final version for publication

We revisit a supersymmetric string model for space-time foam, in which bosonic open-string states, such as photons, can possess quantum-gravity-induced velocity fluctuations in vacuum. We argue that the suggestion of light speed variation with lower bound from gamma-ray burst photon time delays can serve as a support for this string-inspired framework, through connecting the experimental finding with model predictions. We also derive the value of the effective quantum-gravity mass in this framework, and give a qualitative study on the model-dependent coefficients. Constraints from birefringent effects and/or photon decays, including the novel $\gamma$-decay constraint obtained here from the latest Tibet AS$\gamma$ near-PeV photon, are also found to be consistent with predictions in such a quantum-gravity scheme. Future observation that can testify further the theory is suggested., Comment: 6 latex pages, final version for publication