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320 results on '"Li, Bao-Zhu"'

22. Impact of Cardiovascular Health Metrics and Genetic Susceptibility on Incident Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study

Author

Gao, Jing-Wei, primary, You, Si, additional, Huang, Ze-Gui, additional, Cai, Yang-Wei, additional, Wu, Yu-Biao, additional, Xiong, Zhuo-Chao, additional, Li, Bao-Zhu, additional, Chen, Yangxin, additional, Wang, Jing-Feng, additional, Zhang, Hai-Feng, additional, Zhang, Shao-Ling, additional, and Liu, Pin-Ming, additional

Published
2023
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23. Altered gut fungi in systemic lupus erythematosus – A pilot study

Author

Li, Bao-Zhu, primary, Wang, Hua, additional, Li, Xian-Bao, additional, Zhang, Qian-Ru, additional, Huang, Rong-Gui, additional, Wu, Hong, additional, Wang, Yi-Yu, additional, Li, Kai-Di, additional, Chu, Xiu-Jie, additional, Cao, Nv-Wei, additional, Zhou, Hao-Yue, additional, Fang, Xin-Yu, additional, Leng, Rui-Xue, additional, Fan, Yin-Guang, additional, Tao, Jin-Hui, additional, Shuai, Zong-Wen, additional, and Ye, Dong-Qing, additional

Published
2022
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40. Verification of SARS-CoV-2-Encoded small RNAs and contribution to Infection-Associated lung inflammation

Author

Nan Xiang Geng, Wei Zhu, Biao Lun Cui, Li Bao Zhu, Xing Chang Luan, Jiang Lin, Rui Xu, Yan Chen, Cheng Liu, Cheng Zhang, Yu Chun Li, and Xin Guo Song

Subjects
Lung, biology, viruses, fungi, RNA virus, respiratory system, biology.organism_classification, medicine.disease, Virology, Virus, respiratory tract diseases, medicine.anatomical_structure, Type I interferon signaling pathway, medicine, Coronaviridae, CXCL11, Interleukin 8, Cytokine storm
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes coronavirus disease 2019 (COVID-19), the respiratory illness responsible for the COVID-19 pandemic. SARS-CoV-2 is a positive-stranded RNA virus belongs to Coronaviridae family. The viral genome of SARS-CoV-2 contains around 29.8 kilobase with a 5′-cap structure and 3′-poly-A tail, and shows 79.2% nucleotide identity with human SARS-CoV-1, which caused the 2002-2004 SARS outbreak. As the successor to SARS-CoV-1, SARS-CoV-2 now has circulated across the globe. There is a growing understanding of SARS-CoV-2 in virology, epidemiology, and clinical management strategies. In this study, we verified the existence of two 18-22 nt small viral RNAs (svRNAs) derived from the same precursor in human specimens infected with SARS-CoV-2, including nasopharyngeal swabs and formalin-fixed paraffin-embedded (FFPE) explanted lungs from lung transplantation of COVID-19 patients. We then simulated and confirmed the formation of these two SARS-CoV-2-Encoded small RNAs in human lung epithelial cells. And the potential pro-inflammatory effects of the splicing and maturation process of these two svRNAs in human lung epithelial cells were also explored. By screening cytokine storm genes and the characteristic expression profiling of COVID-19 in the explanted lung tissues and the svRNAs precursor transfected human lung epithelial cells, we found that the maturation of these two small viral RNAs contributed significantly to the infection associated lung inflammation, mainly via the activation of the CXCL8, CXCL11 and type I interferon signaling pathway. Taken together, we discovered two SARS-CoV-2-Encoded small RNAs and investigated the pro-inflammatory effects during their maturation in human lung epithelial cells, which might provide new insight into the pathogenesis and possible treatment options for COVID-19.

Published
2021

47. sj-pdf-1-lup-10.1177_09612033211025095 - Supplemental material for Systemic lupus erythematosus patients have a distinct structural and functional skin microbiota compared with controls

Author

Zhou, Hao-Yue, Cao, Nv-Wei, Guo, Biao, Chen, Wen-Jun, Tao, Jin-Hui, Chu, Xiu-Jie, Meng, Xiang, Zhang, Tian-Xiang, and Li, Bao-Zhu

Subjects
111702 Aged Health Care, FOS: Health sciences
Abstract

Supplemental material, sj-pdf-1-lup-10.1177_09612033211025095 for Systemic lupus erythematosus patients have a distinct structural and functional skin microbiota compared with controls by Hao-Yue Zhou, Nv-Wei Cao, Biao Guo, Wen-Jun Chen, Jin-Hui Tao, Xiu-Jie Chu, Xiang Meng, Tian-Xiang Zhang and Bao-Zhu Li in Lupus

Published
2021
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