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2. Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with alcohol use disorder

Author

Leclercq, Sophie, primary, Ahmed, Hany, additional, Amadieu, Camille, additional, Petit, Géraldine, additional, Koistinen, Ville, additional, Leyrolle, Quentin, additional, Poncin, Marie, additional, Stärkel, Peter, additional, Kok, Eloise, additional, Karhunen, Pekka J., additional, De Timary, Philippe, additional, Layé, Sophie, additional, Neyrinck, Audrey M., additional, Kärkkäinen, Olli, additional, Hanhineva, Kati, additional, and Delzenne, Nathalie M., additional

Published
2024
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3. Prebiotic effect on mood in obese patients is determined by the initial gut microbiota composition: A randomized, controlled trial

Author

Leyrolle, Quentin, Cserjesi, Renata, D.G.H. Mulders, Maria, Zamariola, Giorgia, Hiel, Sophie, Gianfrancesco, Marco A., Portheault, Daphné, Amadieu, Camille, Bindels, Laure B., Leclercq, Sophie, Rodriguez, Julie, Neyrinck, Audrey M., Cani, Patrice D., Lanthier, Nicolas, Trefois, Pierre, Bindelle, Jérome, Paquot, Nicolas, Cnop, Miriam, Thissen, Jean-Paul, Klein, Olivier, Luminet, Olivier, and Delzenne, Nathalie M.

Published
2021
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7. List of Contributors

Author

Alhomida, Abdullah S., primary, Barbey, Aron K., additional, Bellomo, Antonello, additional, Bhatia, Harsharan S., additional, Boccardi, Virginia, additional, Boronat, Anna, additional, Bruno, Giuseppe, additional, Canevelli, Marco, additional, Cesari, Matteo, additional, Choudhary, Sunayna, additional, Custodero, Carlo, additional, D’Introno, Alessia, additional, Daniele, Antonio, additional, Das, Undurti N., additional, de la Torre, Rafael, additional, Dhir, Ashish, additional, Dierssen, Mara, additional, Dyall, Simon C., additional, Farooqui, Akhlaq A., additional, Farooqui, Tahira, additional, Felix-Soriano, Elisa, additional, Fitó, Montserrat, additional, Garg, Geetika, additional, Greco, Antonio, additional, Hegde, Mahabaleshwar V., additional, Jewell, Dennis E., additional, Joffre, Corinne, additional, Joshi, Asavari, additional, Klimova, Blanka, additional, Knight, Alissa, additional, Kuca, Kamil, additional, Layé, Sophie, additional, Leyrolle, Quentin, additional, Logroscino, Giancarlo, additional, Lozupone, Madia, additional, Malik, Jai, additional, Mecocci, Patrizia, additional, Moreno-Aliaga, María J., additional, Nadjar, Agnes, additional, Pandey, Kanti Bhooshan, additional, Pandima Devi, Kasi, additional, Panickar, Kiran S., additional, Panza, Francesco, additional, Piccininni, Marco, additional, Ramirez, María J., additional, Rizvi, Syed Ibrahim, additional, Rodríguez-Morató, Jose, additional, Sathya, Sethuraman, additional, Seripa, Davide, additional, Shamsul Ola, Mohammad, additional, Singh, Abhishek K., additional, Singh, Sandeep, additional, Solas, Maite, additional, Solfrizzi, Vincenzo, additional, Stallone, Roberta, additional, Stella, Eleonora, additional, Tavener, Selena K., additional, Tinarelli, Clara, additional, Valiani, Vincenzo, additional, Vanacore, Nicola, additional, Zamroziewicz, Marta K., additional, and Zanwar, Anand A., additional

Published
2018
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8. Microbiota-derived metabolites as drivers of gut-brain communication

Author

Ahmed, Hany, Leyrolle, Quentin, Koistinen, Ville, Kärkkäinen, Olli, Layé, Sophie, Delzenne, Nathalie M., Hanhineva, Kati, and UCL - SSS/LDRI - Louvain Drug Research Institute

Subjects
Amyloid beta-Peptides, gut-brain axis, Autism Spectrum Disorder, short-chain fatty acids, Brain, Humans, Gut microbiota, Fatty Acids, Volatile, metabolism, metabolites, Gastrointestinal Microbiome
Abstract

Alterations in the gut microbiota composition have been associated with a range of neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes transform and metabolize dietary- and host-derived molecules generating a diverse group of metabolites with local and systemic effects. The bi-directional communication between brain and the microbes residing in the gut, the so-called gut-brain axis, consists of a network of immunological, neuronal, and endocrine signaling pathways. Although the full variety of mechanisms of the gut-brain crosstalk is yet to be established, the existing data demonstrates that a single metabolite or its derivatives are likely among the key inductors within the gut-brain axis communication. However, more research is needed to understand the molecular mechanisms underlying how gut microbiota associated metabolites alter brain functions, and to examine if different interventional approaches targeting the gut microbiota could be used in prevention and treatment of neurological disorders, as reviewed herein.

Published
2022

9. N-3 PUFAs and neuroinflammatory processes in cognitive disorders

Author

Leyrolle Quentin, Layé Sophie, and Nadjar Agnès

Subjects
Neuroinflammation, microglia, n-3 polyunsaturated fatty acids, cognitive disorders, Alzheimer disease, Oils, fats, and waxes, TP670-699
Abstract

With the ageing population and increased cases of neurodegenerative diseases, there is a crucial need for the development of new nutritional approaches to prevent and delay the onset of cognitive decline. Neuroinflammatory processes contribute to neuronal damage that underpins neurodegenerative disorders. Growing evidence sheds light on the use of dietary n-3 long chain polyunsaturated fatty acids to improve cognitive performances and reduce the neuroinflammatory responses occurring with age and neurodegenerative pathologies. This review will summarise the most recent information related to the impact and mechanisms underlying the neuroinflammatory processes in cognitive disorders. We will also discuss the mechanisms underlying n-3 polyunsaturated fatty acids effect on neuroinflammation and memory decline.

Published
2016
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10. Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients

Author

Leyrolle, Quentin, primary, Cserjesi, Renata, additional, Demeure, Romane, additional, Neyrinck, Audrey M., additional, Amadieu, Camille, additional, Rodriguez, Julie, additional, Kärkkäinen, Olli, additional, Hanhineva, Kati, additional, Paquot, Nicolas, additional, Cnop, Miriam, additional, Cani, Patrice D., additional, Thissen, Jean-Paul, additional, Bindels, Laure B., additional, Klein, Olivier, additional, Luminet, Olivier, additional, and Delzenne, Nathalie M., additional

Published
2021
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11. Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients

Author

Amadieu, Camille, primary, Coste, Valentin, additional, Neyrinck, Audrey M., additional, Thijssen, Victoria, additional, Leyrolle, Quentin, additional, Bindels, Laure B., additional, Piessevaux, Hubert, additional, Stärkel, Peter, additional, de Timary, Philippe, additional, Delzenne, Nathalie M., additional, and Leclercq, Sophie, additional

Published
2021
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12. Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner

Author

De Meij, Julia, primary, Alfanek, Zain, additional, Morel, Lydie, additional, Decoeur, Fanny, additional, Leyrolle, Quentin, additional, Picard, Katherine, additional, Carrier, Micael, additional, Aubert, Agnes, additional, Séré, Alexandra, additional, Lucas, Céline, additional, Laforest, Gerald, additional, Helbling, Jean-Christophe, additional, Tremblay, Marie-Eve, additional, Cota, Daniela, additional, Moisan, Marie-Pierre, additional, Marsicano, Giovanni, additional, Layé, Sophie, additional, and Nadjar, Agnès, additional

Published
2021
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13. N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development

Author

Leyrolle, Quentin, primary, Decoeur, Fanny, additional, Dejean, Cyril, additional, Brière, Galadriel, additional, Leon, Stephane, additional, Bakoyiannis, Ioannis, additional, Baroux, Emilie, additional, Sterley, Tony‐Lee, additional, Bosch‐Bouju, Clémentine, additional, Morel, Lydie, additional, Amadieu, Camille, additional, Lecours, Cynthia, additional, St‐Pierre, Marie‐Kim, additional, Bordeleau, Maude, additional, Roumes, Helene, additional, De Smedt‐Peyrusse, Véronique, additional, Séré, Alexandran, additional, Schwendimann, Leslie, additional, Grégoire, Stephane, additional, Bretillon, Lionel, additional, Acar, Niyazi, additional, Joffre, Corinne, additional, Ferreira, Guillaume, additional, Uricaru, Raluca, additional, Thebault, Patricia, additional, Gressens, Pierre, additional, Tremblay, Marie‐Eve, additional, Layé, Sophie, additional, and Nadjar, Agnes, additional

Published
2021
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15. Specific gut microbial, biological, and psychiatric profiling related to binge eating disorders: A cross-sectional study in obese patients

Author

Leyrolle, Quentin, primary, Cserjesi, Renata, additional, Mulders, Maria D.G.H., additional, Zamariola, Giorgia, additional, Hiel, Sophie, additional, Gianfrancesco, Marco A., additional, Rodriguez, Julie, additional, Portheault, Daphnée, additional, Amadieu, Camille, additional, Leclercq, Sophie, additional, Bindels, Laure B., additional, Neyrinck, Audrey M., additional, Cani, Patrice D., additional, Karkkainen, Olli, additional, Hanhineva, Kati, additional, Lanthier, Nicolas, additional, Trefois, Pierre, additional, Paquot, Nicolas, additional, Cnop, Miriam, additional, Thissen, Jean-Paul, additional, Klein, Olivier, additional, Luminet, Olivier, additional, and Delzenne, Nathalie M., additional

Published
2021
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16. Link between gut microbiota and health outcomes in inulin -treated obese patients: Lessons from the Food4Gut multicenter randomized placebo-controlled trial

Author

Hiel, Sophie, primary, Gianfrancesco, Marco A., additional, Rodriguez, Julie, additional, Portheault, Daphnée, additional, Leyrolle, Quentin, additional, Bindels, Laure B., additional, Gomes da Silveira Cauduro, Carolina, additional, Mulders, Maria D.G.H., additional, Zamariola, Giorgia, additional, Azzi, Anne-Sophie, additional, Kalala, Gaetan, additional, Pachikian, Barbara D., additional, Amadieu, Camille, additional, Neyrinck, Audrey M., additional, Loumaye, Audrey, additional, Cani, Patrice D., additional, Lanthier, Nicolas, additional, Trefois, Pierre, additional, Klein, Olivier, additional, Luminet, Olivier, additional, Bindelle, Jérôme, additional, Paquot, Nicolas, additional, Cnop, Miriam, additional, Thissen, Jean-Paul, additional, and Delzenne, Nathalie M., additional

Published
2020
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17. Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder

Author

Leclercq, Sophie, primary, Le Roy, Tiphaine, additional, Furgiuele, Sonia, additional, Coste, Valentin, additional, Bindels, Laure B., additional, Leyrolle, Quentin, additional, Neyrinck, Audrey M., additional, Quoilin, Caroline, additional, Amadieu, Camille, additional, Petit, Géraldine, additional, Dricot, Laurence, additional, Tagliatti, Vanessa, additional, Cani, Patrice D., additional, Verbeke, Kristin, additional, Colet, Jean-Marie, additional, Stärkel, Peter, additional, de Timary, Philippe, additional, and Delzenne, Nathalie M., additional

Published
2020
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18. N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development.

Author

Leyrolle, Quentin, Decoeur, Fanny, Dejean, Cyril, Brière, Galadriel, Leon, Stephane, Bakoyiannis, Ioannis, Baroux, Emilie, Sterley, Tony‐Lee, Bosch‐Bouju, Clémentine, Morel, Lydie, Amadieu, Camille, Lecours, Cynthia, St‐Pierre, Marie‐Kim, Bordeleau, Maude, De Smedt‐Peyrusse, Véronique, Séré, Alexandran, Schwendimann, Leslie, Grégoire, Stephane, Bretillon, Lionel, and Acar, Niyazi

Published
2022
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20. Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients

Author

Rodriguez, Julie, primary, Hiel, Sophie, additional, Neyrinck, Audrey M, additional, Le Roy, Tiphaine, additional, Pötgens, Sarah A, additional, Leyrolle, Quentin, additional, Pachikian, Barbara D, additional, Gianfrancesco, Marco A, additional, Cani, Patrice D, additional, Paquot, Nicolas, additional, Cnop, Miriam, additional, Lanthier, Nicolas, additional, Thissen, Jean-Paul, additional, Bindels, Laure B, additional, and Delzenne, Nathalie M, additional

Published
2020
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21. Food4Gut multicenter randomized placebo-controlled trial. v1

Author

Hiel, Sophie, primary, A. Gianfrancesco, Marco, additional, Rodriguez, Julie, additional, Portheault, Daphnée, additional, Leyrolle, Quentin, additional, B. Bindels, Laure, additional, Gomes da Silveira Cauduro, Carolina, additional, D.G.H. Mulders, Maria, additional, Zamariola, Giorgia, additional, Azzi, Anne-Sophie, additional, Kalala, Gaetan, additional, D. Pachikian, Barbara, additional, Amadieu, Camille, additional, M. Neyrinck, Audrey, additional, Loumaye, Audrey, additional, D. Cani, Patrice, additional, Lanthier, Nicolas, additional, Trefois, Pierre, additional, Klein, Olivier, additional, Luminet, Olivier, additional, Bindelle, Jérôme, additional, Paquot, Nicolas, additional, Cnop, Miriam, additional, Thissen, Jean-Paul, additional, and M. Delzenne, Nathalie, additional

Published
2019
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22. Early-life PUFAs modulate shaping of neuronal circuits by microglia

Author

Leyrolle, Quentin, MADORE, Charlotte, Joffre, Corinne, Gressens, P., Laye, Sophie, Nadjar, Agnès, Nutrition et Neurobiologie intégrée (NutriNeuro), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, Neuroprotection du Cerveau en Développement / Promoting Research Oriented Towards Early Cns Therapies (PROTECT), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Diderot - Paris 7 (UPD7), Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Womens Hospital, Harvard Medical School [Boston] (HMS), Nutrition et Neurobiologie intégrée (NutriNeur0), Ecole nationale supérieure de chimie, biologie et physique-Institut Polytechnique de Bordeaux-Université Sciences et Technologies - Bordeaux 1-Institut National de la Recherche Agronomique (INRA)-Université Bordeaux Segalen - Bordeaux 2, and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
nervous system, [SDV]Life Sciences [q-bio], food and beverages, microglia, cerveau, lipids (amino acids, peptides, and proteins), ComputingMethodologies_GENERAL, santé humaine, human health, microglie, eye diseases
Abstract

Early-life PUFAs modulate shaping of neuronal circuits by microglia. 13. European Meeting on Glial Cells in Health and Disease

Published
2017

23. Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling

Author

Abiega, Oihane, Beccari, Sol, Diaz-Aparicio, Irune, Nadjar, Agnes, Layé, Sophie, Leyrolle, Quentin, Gómez-Nicola, Diego, Domercq, María, Pérez-Samartín, Alberto, Sánchez-Zafra, Víctor, Paris, Iñaki, Valero, Jorge, Savage, Julie C., Hui, Chin-Wai, Tremblay, Marie-Ève, Deudero, Juan J. P., Brewster, Amy L., Anderson, Anne E., Zaldumbide, Laura, Galbarriatu, Lara, Marinas, Ainhoa, Vivanco, Maria dM., Matute, Carlos, Maletic-Savatic, Mirjana, Encinas, Juan M., and Sierra, Amanda

Subjects
Correction
Published
2016

24. Dietary omega-3 alleviates from long-term behavioral deficits in a model of prenatal infection

Author

Leyrolle, Quentin, ProdInra, Migration, Nutrition et Neurobiologie intégrée (NutriNeuro), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, and Institut National de Recherche Agronomique (INRA). UMR Nutrition et Neurobiologie intégrée (1286).

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2016

25. Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling

Author

Abiega, Oihane, primary, Beccari, Sol, additional, Diaz-Aparicio, Irune, additional, Nadjar, Agnes, additional, Layé, Sophie, additional, Leyrolle, Quentin, additional, Gómez-Nicola, Diego, additional, Domercq, María, additional, Pérez-Samartín, Alberto, additional, Sánchez-Zafra, Víctor, additional, Paris, Iñaki, additional, Valero, Jorge, additional, Savage, Julie C., additional, Hui, Chin-Wai, additional, Tremblay, Marie-Ève, additional, Deudero, Juan J. P., additional, Brewster, Amy L., additional, Anderson, Anne E., additional, Zaldumbide, Laura, additional, Galbarriatu, Lara, additional, Marinas, Ainhoa, additional, Vivanco, Maria dM., additional, Matute, Carlos, additional, Maletic-Savatic, Mirjana, additional, Encinas, Juan M., additional, and Sierra, Amanda, additional

Published
2016
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27. Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients.

Author

Leyrolle, Quentin, Cserjesi, Renata, Demeure, Romane, Neyrinck, Audrey M., Amadieu, Camille, Rodriguez, Julie, Kärkkäinen, Olli, Hanhineva, Kati, Paquot, Nicolas, Cnop, Miriam, Cani, Patrice D., Thissen, Jean-Paul, Bindels, Laure B., Klein, Olivier, Luminet, Olivier, and Delzenne, Nathalie M.

Abstract

Obesity is associated with an increased risk of several neurological and psychiatric diseases, but few studies report the contribution of biological features in the occurrence of mood disorders in obese patients. The aim of the study is to evaluate the potential links between serum metabolomics and gut microbiome, and mood disturbances in a cohort of obese patients. Psychological, biological characteristics and nutritional habits were evaluated in 94 obese subjects from the Food4Gut study stratified according to their mood score assessed by the Positive and Negative Affect Schedule (PANAS). The fecal gut microbiota and plasma non-targeted metabolomics were analysed. Obese subjects with increased negative mood display elevated levels of Coprococcus as well as decreased levels of Sutterella and Lactobacillus. Serum metabolite profile analysis reveals in these subjects altered levels of several amino acid-derived metabolites, such as an increased level of L-histidine and a decreased in phenylacetylglutamine, linked to altered gut microbiota composition and function rather than to differences in dietary amino acid intake. Regarding clinical profile, we did not observe any differences between both groups. Our results reveal new microbiota-derived metabolites that characterize the alterations of mood in obese subjects, thereby allowing to propose new targets to tackle mood disturbances in this context. Food4gut, clinicaltrial.gov: NCT03852069. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota

Author

Madore, Charlotte, Leyrolle, Quentin, Lacabanne, Chloé, Benmamar-Badel, Anouk, Joffre, Corinne, Nadjar, Agnes, and Layé, Sophie

Abstract

Several genetic causes of autism spectrum disorder (ASD) have been identified. However, more recent work has highlighted that certain environmental exposures early in life may also account for some cases of autism. Environmental insults during pregnancy, such as infection or malnutrition, seem to dramatically impact brain development. Maternal viral or bacterial infections have been characterized as disruptors of brain shaping, even if their underlying mechanisms are not yet fully understood. Poor nutritional diversity, as well as nutrient deficiency, is strongly associated with neurodevelopmental disorders in children. For instance, imbalanced levels of essential fatty acids, and especially polyunsaturated fatty acids (PUFAs), are observed in patients with ASD and other neurodevelopmental disorders (e.g., attention deficit hyperactivity disorder (ADHD) and schizophrenia). Interestingly, PUFAs, and specifically n-3 PUFAs, are powerful immunomodulators that exert anti-inflammatory properties. These prenatal dietary and immunologic factors not only impact the fetal brain, but also affect the microbiota. Recent work suggests that the microbiota could be the missing link between environmental insults in prenatal life and future neurodevelopmental disorders. As both nutrition and inflammation can massively affect the microbiota, we discuss here how understanding the crosstalk between these three actors could provide a promising framework to better elucidate ASD etiology.

Published
2016
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29. Discovery of the gut microbial signature driving the efficacy of prebiotic intervention on liver steatosis

Author

Rodriguez, Julie, Nicolas Lanthier, Hiel, Sophie, Neyrinck, Audrey M., Le Roy, Tiphaine, Pötgens, Sarah, Leyrolle, Quentin, Barbara Pachikian, Gianfrancesco, Ma, Pd, Cani, Paquot, Nicolas, Cnop, M., Thissen, Jean-Paul, Bindels, Laure B., Nathalie Delzenne, UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, and UCL - (SLuc) Service de gastro-entérologie

Subjects
obesity, mice, gut microbiota, inulin, hepatic steatosis, prebiotics
Abstract

Introduction : Dietary supplementation with inulin as a prebiotic has been shown to lessen obesity and related metabolic disorders in some individuals. Previous work highlighted the interest of prebiotic supplementation in the management of hepatic steatosis in preclinical models. However, the efficiency of such nutritional interventions in humans remains unclear. Aim : Using a cohort of obese individuals treated with inulin versus placebo (FOOD4GUT cohort), and a model of mice transferred with the fecal microbiota from obese patients, we have addressed the following question : do the characteristics of the gut microbiota in obese individuals influence the effect of inulin on hepatic disorders? Methods : The gut microbiota of four-week old mice was depleted using antibiotics. Four groups of mice were then colonized with stools from four human obese patients (hum-ob) selected for different gut microbiota composition, presence of hepatic steatosis and response to inulin in an interventional study. Conventional and hum-ob mice were then fed with a high-fat diet (HFD) during four additional weeks, supplemented or not with native inulin (Cosucra) (6-9 mice per group). Results : We demonstrated a different response to inulin supplementation in the four groups of mice inoculated with different fecal material. Inulin significantly reduced the hepatic lipid content in mice inoculated with the faeces of two out of the four donors. The decrease in hepatic lipid accumulation in “responder” mice was associated with a reduced activation of nuclear expression of markers involved in lipids synthesis (SREBP1 and SREBP2 proteins).. Despite an increased cecal content – signing gut fermentation - observed in all humanized mice, the regulation of the gut microbiota by inulin also differed between donors. Interestingly, some bacterial genera were positively correlated with liver lipids and triglycerides (Barnesiella, Bilophila, Butyricimonas…) whereas some others ones are negatively associated with these parameters (such as Akkermansia or Clostridium XIVa). The different regulation of these bacteria by inulin may explain the observed difference on hepatic lipid metabolism in responder and non-responders in humans. Conclusions : Our work using a model of gut microbiota transfer from patients into mice highlighted the differential response of humanized mice to dietary supplementation with inulin. We propose that the gut microbiota is an important component to take into account for personalized nutrition related to prebiotic dietary fibers in the future and the management of metabolic disorders including hepatic steatosis.

30. Gut2Behave project - Data Management Plan

Author

Neyrinck, Audrey M., Delzenne, Nathalie M., Leclercq, Sophie, Ahmed, Hany, Kärkkäinen, Olli, Leyrolle, Quentin, Amadieu, Camille, Starkel, Peter, De Timary, Philippe, Pallet, Véronique, Thissen, Jean-Paul, Layé, Sophie, and Hanhineva, Kati

Subjects
Gut2Behave project, FAIR principles, Data Management Plan, DMP
Abstract

Gut2Behave is a project that was initiated from the european ERANET-NEURON network (Joint Transnational call 2019 “Biomarkers”) . The aim of the project is to propose biomarkers involved in gut-brain axis to control emotional and cognitive functions to better stratify patients and to design innovative treatment in the context of alcohol use disorder or obesity (https://www.gut2behave.eu/). A Data Management Plan (DMP) has been developed as Deliverable of the project, by taking into account the template of the “Horizon 2020 FAIR DMP” from DMPonline.be. It summarizes information about the type and format of data that will be collected and generated, its origin, data utility and how Gut2Behave project research data will be findable, accessible, interoperable and reusable (i.e. FAIR). The purpose of this DMP is to provide the members of the consortium with an analysis of the main elements of the data management policy regarding all the datasets generated during the project., Gut2Behave project was initiated from the european ERANET-NEURON network and was funded by the Fonds de la recherche Scientifique in Belgium (FRS-FNRS, convention PINTMULTI R.8013.19), the French National Research Agency (ANR) and the Academy of Finland (AKA).

Published
2022
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