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2. A Comparison of Two Delivery Modalities of a Mobile Phone-Based Assessment for Serious Mental Illness: Native Smartphone Application vs Text-Messaging Only Implementations

Author

Ainsworth, John, Palmier-Claus, Jasper E, Machin, Matthew, Barrowclough, Christine, Dunn, Graham, Rogers, Anne, Buchan, Iain, Barkus, Emma, Kapur, Shitij, Wykes, Til, Hopkins, Richard S, and Lewis, Shôn

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundMobile phone–based assessment may represent a cost-effective and clinically effective method of monitoring psychotic symptoms in real-time. There are several software options, including the use of native smartphone applications and text messages (short message service, SMS). Little is known about the strengths and limitations of these two approaches in monitoring symptoms in individuals with serious mental illness. ObjectiveThe objective of this study was to compare two different delivery modalities of the same diagnostic assessment for individuals with non-affective psychosis—a native smartphone application employing a graphical, touch user interface against an SMS text-only implementation. The overall hypothesis of the study was that patient participants with sewrious mental illness would find both delivery modalities feasible and acceptable to use, measured by the quantitative post-assessment feedback questionnaire scores, the number of data points completed, and the time taken to complete the assessment. It was also predicted that a native smartphone application would (1) yield a greater number of data points, (2) take less time, and (3) be more positively appraised by patient participant users than the text-based system. MethodsA randomized repeated measures crossover design was employed. Participants with currently treated Diagnostic and Statistical Manual (Fourth Edition) schizophrenia or related disorders (n=24) were randomly allocated to completing 6 days of assessment (four sets of questions per day) with a native smartphone application or the SMS text-only implementation. There was then a 1-week break before completing a further 6 days with the alternative delivery modality. Quantitative feedback questionnaires were administered at the end of each period of sampling. ResultsA greater proportion of data points were completed with the native smartphone application in comparison to the SMS text-only implementation (β = -.25, SE=.11, P=.02), which also took significantly less time to complete (β =.78, SE= .09, P

Published
2013
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4. Network analysis of inflammation and symptoms in recent onset schizophrenia and the influence of minocycline during a clinical trial

Author

Herniman, Sarah E., Wood, Stephen J., Khandaker, Golam, Dazzan, Paola, Pariante, Carmine M., Barnes, Nicholas M., Krynicki, Carl R., Nikkheslat, Naghmeh, Vincent, Rachel C., Roberts, Alex, Giordano, Annalisa, Watson, Andrew, Suckling, John, Barnes, Thomas R. E., Husain, Nusrat, Jones, Peter B., Joyce, Eileen, Lawrie, Stephen M., Lewis, Shôn, Deakin, Bill, and Upthegrove, Rachel

Published
2023
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9. The EMPOWER blended digital intervention for relapse prevention in schizophrenia: a feasibility cluster randomised controlled trial in Scotland and Australia

Author

Gumley, Andrew I, Bradstreet, Simon, Ainsworth, John, Allan, Stephanie, Alvarez-Jimenez, Mario, Aucott, Lorna, Birchwood, Maximillian, Briggs, Andrew, Bucci, Sandra, Cotton, Sue M, Engel, Lidia, French, Paul, Lederman, Reeva, Lewis, Shôn, Machin, Matthew, MacLennan, Graeme, McLeod, Hamish, McMeekin, Nicola, Mihalopoulos, Cathy, Morton, Emma, Norrie, John, Schwannauer, Matthias, Singh, Swaran P, Sundram, Suresh, Thompson, Andrew, Williams, Chris, Yung, Alison R, Farhall, John, and Gleeson, John

Published
2022
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10. Impaired verbal memory function is related to anterior cingulate glutamate levels in schizophrenia: findings from the STRATA study

Author

Griffiths, Kira, Egerton, Alice, Millgate, Edward, Anton, Adriana, Barker, Gareth J., Deakin, Bill, Drake, Richard, Eliasson, Emma, Gregory, Catherine J., Howes, Oliver D., Kravariti, Eugenia, Lawrie, Stephen M., Lewis, Shôn, Lythgoe, David J., Murphy, Anna, McGuire, Philip, Semple, Scott, Stockton-Powdrell, Charlotte, Walters, James T. R., Williams, Stephen R., and MacCabe, James H.

Published
2022
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14. Deconstructing depression and negative symptoms of schizophrenia; differential and longitudinal immune correlates, and response to minocycline treatment

Author

Krynicki, Carl R., Dazzan, Paola, Pariante, Carmine M., Barnes, Nicholas M., Vincent, Rachel C., Roberts, Alex, Giordano, Annalisa, Watson, Andrew, Suckling, John, Barnes, Thomas R.E., Husain, Nusrat, Jones, Peter B., Joyce, Eileen, Lawrie, Stephen M., Lewis, Shôn, Deakin, Bill, and Upthegrove, Rachel

Published
2021
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20. The benefit of minocycline on negative symptoms of schizophrenia in patients with recent-onset psychosis (BeneMin): a randomised, double-blind, placebo-controlled trial

Author

Deakin, Bill, Suckling, John, Barnes, Thomas R E, Byrne, Kelly, Chaudhry, Imran B, Dazzan, Paola, Drake, Richard J, Giordano, Annalisa, Husain, Nusrat, Jones, Peter B, Joyce, Eileen, Knox, Emma, Krynicki, Carl, Lawrie, Stephen M, Lewis, Shôn, Lisiecka-Ford, Danuta M, Nikkheslat, Naghmeh, Pariante, Carmine M, Smallman, Richard, Watson, Andrew, Williams, Steven C R, Upthegrove, Rachel, and Dunn, Graham

Published
2018
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21. Amisulpride and olanzapine followed by open-label treatment with clozapine in first-episode schizophrenia and schizophreniform disorder (OPTiMiSE): a three-phase switching study

Author

Kahn, René S, Sommer, Iris E, Winter-van Rossum, Inge, Somers, Metten, Ywema, Paula C, Kapur, Shitisj, McGuire, Philip, Leboyer, Marion, Meyer-Lindenberg, Andreas, Lewis, Shon W, Leucht, Stefan, Arango, Celso, Fleischhacker, Wolfgang W, Meijering, Anne Lotte, Petter, Jocelyn, Van de Brug, Resy, Schotsman, Joost, Zwerver, Jildou, Peuskens, Jos, De Hert, Marc, Thys, Erik, Hranov, Lucho G, Hranov, Valentin, Libiger, Jan, Köhler, Richard, Mohr, Pavel, Glenthoj, Birte, Broberg, Brian, Düring, Signe, Baandrup, Lone, Jamain, Stephane, Heres, Stephan, Rujescu, Dan, Giegling, Ina, Weiser, Mark, Bar Heim, Mor, Davidson, Michael, Galderisi, Silvana, Bucci, Paola, Mucci, Armida, Rybakowski, Janusz, Remlinger-Molenda, Agnieszka, Gonen, Ilan, Radu, Paull, Díaz-Marsá, Marina, Rodriguez, Alberto, Palomo, Tomas, Rodriguez-Jimenez, Roberto, García-Portilla, Paz, Bernardo, Miquel, Bobes, Julio, Vilares Oliveira, Christina, Berger, Gregor, Wildt, Claudia, Dazzan, Paola, Perez-Iglesias, Roccio, Drake, Richard, Gregory, Sarah, Wilson, Danielle, Díaz-Caneja, Covadonga M, Eijkemans, Marinus J C, Winter van Rossum, Inge, Glenthøj, Birte, Fleischhacker, W Wolfgang, and Kapur, Shitij

Published
2018
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22. Acceptability and experience of a smartphone symptom monitoring app for people with psychosis in China (YouXin): a qualitative study.

Author

Xiaolong Zhang, Lewis, Shôn, Xu Chen, Jiaojiao Zhou, Xingyu Wang, and Bucci, Sandra

Abstract

Background Access to high-quality mental healthcare remains challenging for people with psychosis globally, including China. Smartphone-based symptom monitoring has the potential to support scalable mental healthcare. However, no such tool, until now, has been developed and evaluated for people with psychosis in China. This study investigated the acceptability and the experience of using a symptom self-monitoring smartphone app (YouXin) specifically developed for people with psychosis in China. Methods Semi-structured interviews were conducted with 10 participants with psychosis to explore the acceptability of YouXin. Participants were recruited from the non-randomised feasibility study that tested the validity, feasibility, acceptability and safety of the YouXin app. Data analysis was guided by the theoretical framework of acceptability. Results Most participants felt the app was acceptable and easy to use, and no unbearable burdens or opportunity costs were reported. Participants found completing the self-monitoring app rewarding and experienced a sense of achievement. Privacy and data security were not major concerns for participants, largely due to trust in their treating hospital around data protection. Participants found the app easy to use and attributed this to the training provided at the beginning of the study. A few participants said they had built some form of relationship with the app and would miss the app when the study finished. Conclusions The YouXin app is acceptable for symptom self-monitoring in people with experience of psychosis in China. Participants gained greater insights about their symptoms by using the YouXin app. As we only collected retrospective acceptability in this study, future studies are warranted to assess hypothetical acceptability before the commencement of study to provide a more comprehensive understanding of implementation. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Technology use and attitudes towards digital mental health in people with severe mental health problems: a survey study in China.

Author

Xiaolong Zhang, Lewis, Shôn, Xu Chen, Berry, Natalie, and Bucci, Sandra

Subjects
MENTAL illness, ATTITUDES toward technology, MENTAL health surveys, MENTAL health services, DIGITAL health
Abstract

Introduction: Digital mental health is a promising solution to support people with severe mental health problems (SMI) in China. However, little is known about the ownership rate of digital technologies and attitudes towards utilising digital health technologies (DHTs) among people with SMI in the Chinese context. The aims of this study were to understand: (i) digital technology ownership and usage rate of people with SMI in China; (ii) attitudes toward DHTs in mental health services; and (iii) how the COVID-19 pandemic has influenced views on digital mental health. Methods: A cross-sectional survey was given to outpatients with SMI using the REDCap platform. To capture a diverse sample of people with SMI, the survey was distributed across psychiatric hospitals, general hospitals with a psychiatric unit, secondary hospitals, and community healthcare centres. Results: In total, 447 survey respondents completed the survey. Relative high ownership rates of digital technologies were found, with smartphone ownership (95.5%) and access to the internet (82.1%) being the highest technologies reported. However, less than half of respondents reported frequent health-related usage of digital technologies, which may be related to the lack of knowledge in using DHTs. Most respondents found DHTs being useful for access to mental health services during the pandemic and were willing to use DHTs after the pandemic. Discussion: Our data suggest that, despite the high ownership rate of digital technologies, training programmes to improve digital health literacy for people with SMI in China are necessary to realise the full potential of digital mental health. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Mental health research priorities for Europe

Author

Wykes, Til, Haro, Josep Maria, Belli, Stefano R, Obradors-Tarragó, Carla, Arango, Celso, Ayuso-Mateos, José Luis, Bitter, István, Brunn, Matthias, Chevreul, Karine, Demotes-Mainard, Jacques, Elfeddali, Iman, Evans-Lacko, Sara, Fiorillo, Andrea, Forsman, Anna K, Hazo, Jean-Baptiste, Kuepper, Rebecca, Knappe, Susanne, Leboyer, Marion, Lewis, Shôn W, Linszen, Donald, Luciano, Mario, Maj, Mario, McDaid, David, Miret, Marta, Papp, Szilvia, Park, A-La, Schumann, Gunter, Thornicroft, Graham, van der Feltz-Cornelis, Christina, van Os, Jim, Wahlbeck, Kristian, Walker-Tilley, Tom, and Wittchen, Hans-Ulrich

Published
2015
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33. Stratified medicine for mental disorders

Author

Schumann, Gunter, Binder, Elisabeth B., Holte, Arne, de Kloet, E. Ronald, Oedegaard, Ketil J., Robbins, Trevor W., Walker-Tilley, Tom R., Bitter, Istvan, Brown, Verity J., Buitelaar, Jan, Ciccocioppo, Roberto, Cools, Roshan, Escera, Carles, Fleischhacker, Wolfgang, Flor, Herta, Frith, Chris D., Heinz, Andreas, Johnsen, Erik, Kirschbaum, Clemens, Klingberg, Torkel, Lesch, Klaus-Peter, Lewis, Shon, Maier, Wolfgang, Mann, Karl, Martinot, Jean-Luc, Meyer-Lindenberg, Andreas, Müller, Christian P., Müller, Walter E., Nutt, David J., Persico, Antonio, Perugi, Giulio, Pessiglione, Mathias, Preuss, Ulrich W., Roiser, Jonathan P., Rossini, Paolo M., Rybakowski, Janusz K., Sandi, Carmen, Stephan, Klaas E., Undurraga, Juan, Vieta, Eduard, van der Wee, Nic, Wykes, Til, Haro, Josep Maria, and Wittchen, Hans Ulrich

Published
2014
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34. Anterior Cingulate Glutamate Metabolites as a Predictor of Antipsychotic Response in First Episode Psychosis: data from the STRATA collaboration.

Author

Egerton, Alice, primary, Griffiths, Kira, additional, Casetta, Cecila, additional, Deakin, John, additional, Drake, Richard, additional, Howes, Oliver, additional, Kassoumeri, Laura, additional, Khan, Sobia, additional, Lankshear, Steve, additional, Lees, Jane, additional, Lewis, Shôn, additional, Mikulskaya, Elena, additional, Millgate, Edward, additional, Oloyede, Ebenezer, additional, Pollard, Rebecca, additional, Rich, Nathalie, additional, Segev, Aviv, additional, Sendt, Kyra-Verena, additional, and MacCabe, James, additional

Published
2022
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39. Cognitive function in early-phase schizophrenia-spectrum disorder: IQ subtypes, brain volume and immune markers.

Author

Watson, Andrew J., Giordano, Annalisa, Suckling, John, Barnes, Thomas R. E., Husain, Nusrat, Jones, Peter B., Krynicki, Carl R., Lawrie, Stephen M., Lewis, Shôn, Nikkheslat, Naghmeh, Pariante, Carmine M., Upthegrove, Rachel, Deakin, Bill, Dazzan, Paola, and Joyce, Eileen M.

Subjects
BRAIN anatomy, BIOMARKERS, C-reactive protein, INTERLEUKINS, SCHIZOPHRENIA, PSYCHOSES, COGNITIVE processing speed, COGNITION, IMMUNE system, MAGNETIC resonance imaging, NEUROINFLAMMATION, INTELLECT, TUMOR necrosis factors, VERBAL behavior, RESEARCH funding
Abstract

Background: Evidence suggests that cognitive subtypes exist in schizophrenia that may reflect different neurobiological trajectories. We aimed to identify whether IQ-derived cognitive subtypes are present in early-phase schizophrenia-spectrum disorder and examine their relationship with brain structure and markers of neuroinflammation. Method: 161 patients with recent-onset schizophrenia spectrum disorder (<5 years) were recruited. Estimated premorbid and current IQ were calculated using the Wechsler Test of Adult Reading and a 4-subtest WAIS-III. Cognitive subtypes were identified with k-means clustering. Freesurfer was used to analyse 3.0 T MRI. Blood samples were analysed for hs-CRP, IL-1RA, IL-6 and TNF- α. Results: Three subtypes were identified indicating preserved (PIQ), deteriorated (DIQ) and compromised (CIQ) IQ. Absolute total brain volume was significantly smaller in CIQ compared to PIQ and DIQ, and intracranial volume was smaller in CIQ than PIQ (F (2, 124) = 6.407, p = 0.002) indicative of premorbid smaller brain size in the CIQ group. CIQ had higher levels of hs-CRP than PIQ (F (2, 131) = 5.01, p = 0.008). PIQ showed differentially impaired processing speed and verbal learning compared to IQ-matched healthy controls. Conclusions: The findings add validity of a neurodevelopmental subtype of schizophrenia identified by comparing estimated premorbid and current IQ and characterised by smaller premorbid brain volume and higher measures of low-grade inflammation (CRP). [ABSTRACT FROM AUTHOR]

Published
2023
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41. Digital smartphone intervention to recognise and manage early warning signs in schizophrenia to prevent relapse: the EMPOWER feasibility cluster RCT

Author

Gumley, Andrew I, primary, Bradstreet, Simon, additional, Ainsworth, John, additional, Allan, Stephanie, additional, Alvarez-Jimenez, Mario, additional, Birchwood, Maximillian, additional, Briggs, Andrew, additional, Bucci, Sandra, additional, Cotton, Sue, additional, Engel, Lidia, additional, French, Paul, additional, Lederman, Reeva, additional, Lewis, Shôn, additional, Machin, Matthew, additional, MacLennan, Graeme, additional, McLeod, Hamish, additional, McMeekin, Nicola, additional, Mihalopoulos, Cathy, additional, Morton, Emma, additional, Norrie, John, additional, Reilly, Frank, additional, Schwannauer, Matthias, additional, Singh, Swaran P, additional, Sundram, Suresh, additional, Thompson, Andrew, additional, Williams, Chris, additional, Yung, Alison, additional, Aucott, Lorna, additional, Farhall, John, additional, and Gleeson, John, additional

Published
2022
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43. Cognitive function in early-phase schizophrenia-spectrum disorder: IQ subtypes, brain volume and immune markers

Author

Watson, Andrew J., primary, Giordano, Annalisa, additional, Suckling, John, additional, Barnes, Thomas R. E., additional, Husain, Nusrat, additional, Jones, Peter B., additional, Krynicki, Carl R., additional, Lawrie, Stephen M., additional, Lewis, Shôn, additional, Nikkheslat, Naghmeh, additional, Pariante, Carmine M., additional, Upthegrove, Rachel, additional, Deakin, Bill, additional, Dazzan, Paola, additional, and Joyce, Eileen M., additional

Published
2022
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44. Additional file 1 of Digital screening for postnatal depression: mixed methods proof-of-concept study

Author

Eisner, Emily, Lewis, Shôn, Stockton-Powdrell, Charlotte, Agass, Ria, Whelan, Pauline, and Tower, Clare

Subjects
mental disorders
Abstract

Additional file 1: Figure S1. Example Edinburgh Postnatal Depression Scale item, as displayed by the ClinTouch DAWN-P app. Figure S2. Patterns of app use over the study duration. Table S1. a priori themes describing app acceptability and usability.

Published
2022
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46. Cross-sectional study comparing cognitive function in treatment responsive versus treatment non-responsive schizophrenia: evidence from the STRATA study

Author

Millgate, Edward, primary, Kravariti, Eugenia, additional, Egerton, Alice, additional, Howes, Oliver D, additional, Murray, Robin M, additional, Kassoumeri, Laura, additional, Donocik, Jacek, additional, Lewis, Shôn, additional, Drake, Richard, additional, Lawrie, Stephen, additional, Murphy, Anna, additional, Collier, Tracy, additional, Lees, Jane, additional, Stockton-Powdrell, Charlotte, additional, Walters, James, additional, Deakin, Bill, additional, and MacCabe, James, additional

Published
2021
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49. The Optimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE) Trial: Rationale for its Methodology and a Review of the Effectiveness of Switching Antipsychotics

Author

Leucht, Stefan, Winter-van Rossum, Inge, Heres, Stephan, Arango, Celso, Fleischhacker, W. Wolfgang, Glenthøj, Birte, Leboyer, Marion, Leweke, F. Markus, Lewis, Shôn, McGuire, Phillip, Meyer-Lindenberg, Andreas, Rujescu, Dan, Kapur, Shitij, Kahn, René S., and Sommer, Iris E.

Published
2015
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