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2. Variations in antenatal management and outcomes in haemolytic disease of the fetus and newborn: an international, retrospective, observational cohort study

Author

de Winter, Derek P, Lopriore, Enrico, Thorup, Emilie, Petersen, Olav Bjørn, Dziegiel, Morten H, Sundberg, Karin, Devlieger, Roland, de Catte, Luc, Lewi, Liesbeth, Debeer, Anne, Houfflin-Debarge, Véronique, Ghesquiere, Louise, Garabedian, Charles, Le Duc, Kévin, Antolin, Eugenia, Mendez, Nieves, Castleman, James, Tse, Wing Ting, Jouannic, Jean-Marie, Maurice, Paul, Currie, Jane, Mullen, Emma, Geerts, Lut, Rademan, Kerry, Khalil, Asma, Poljak, Borna, Prasad, Smriti, Tiblad, Eleonor, Bohlin, Kajsa, Geipel, Annegret, Rath, Johanna, Malone, Fergal, Mackin, David, Yinon, Yoav, Cohen, Stav, Ryan, Greg, Vlachodimitropoulou, Evangelia, Gloning, Karl-Philipp, Verlohren, Stefan, Mayer, Beate, Lanna, Mariano, Faiola, Stefano, Sršen, Tanja Premru, Cerar, Lilijana Kornhauser, Snowise, Saul, Sun, Luming, Otaño, Lucas, Meller, César Hernan, Connors, Ngina K, Saxonhouse, Matthew, Wolter, Aline, Bedei, Ivonne, Klaritsch, Philipp, Jauch, Sarah, da Silva Ribeiro, Eduardo Teixeira, Filho, Fernando Maia Peixoto, Martinez-Portilla, Raigam Jafet, Matias, Alexandra, Abad, Obdulia Alejos, Roca, Juan Parra, Grisi, Ángel Guillermo Alcázar, Navarro, Edgar Juan José Chávez, van der Bom, Johanna G, de Haas, Masja, and Verweij, EJT (Joanne)

Published
2024
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4. Monitoring and management of hemolytic disease of the fetus and newborn based on an international expert Delphi consensus

Author

Nassr, Ahmed A., Baschat, Ahmet, Hohnecker, Alexander, Shamshirsaz, Alireza, Luciano, Angel, Debeer, Anne, Geipel, Annegret, Borrell, Antoni, Khalil, Asma, Llorente, Aurora Viejo, Mayer, Beate, Poljak, Borna, van der Schoot, C. Ellen, Taillefer, Catherine, Dame, Christof, Berg, Christoph, Coutinho, Conrado Milani, de Winter, Derek P., Oepkes, Dick, Verweij, E.J.T., Moratonas, Elena Carreras, Tiblad, Eleonor, Bendel-Stenzel, Ellen, Maisonneuve, Emeline, Lopriore, Enrico, Vlachodimitropoulou, Evangelia, Prefumo, Federico, Maia, Fernando, Filho, Peixoto, Molina, Francisca S., Gonzalez, Gerardo Sepulveda, Gardener, Glenn, Sago, Haruhiko, Liley, Helen, Mustafa, Hiba, Schwach, Ingrid, Bedei, Ivonne, Castleman, James, Krivec, Jana Lozar, jouannic, Jean-marie, Miller, Jena, Pereira Nunes, Joana Filipa, Middeldorp, Johanna, Martinez, Josep M., Sundberg, Karin, Bligard, Katherine, Kohari, Katherine, Ishii, Keisuke, Moise, Kenneth, Le Duc, Kévin, Lewi, Liesbeth, Van Wyk, Lizelle, Otaño, Lucas, Sun, Luming, Geerts, Lut, Sanchez-Duran, M. Angeles, Bennasar, Mar, Vaena, Marcella, Gil, Maria M., Weems, Mark F., Kilby, Mark, de Haas, Masja, Saxonhouse, Matthew, Schenone, Mauro, Bahtiyar, Mert Ozan, Zaretsky, Michael V., Martinez Rodriguez, Miguel Angel, Habli, Mounira, Khalek, Nahla, Frost, Natalie, Griffiths, Pamela, Maurice, Paul, Dar, Pe'er, Lindgren, Peter, Chaveeva, Petya, Klaritsch, Philipp, Radhakrishnan, Prathima, Schuler, Rahel, Chmait, Ramen, Rose, Rebecca, Oever, Renske van 't, Jernman, Riina, Christensen, Robert, Cincotta, Robert, Axt-Fliedner, Roland, Devlieger, Roland, Donepudi, Roopali, Kumar, Sailesh, Verlohren, Stefan, Emery, Stephen P., Sainio, Susanna, Mehra, Suwan, Premru-Srsen, Tanja, Legler, Tobias, Sachs, Ulrich J., Basal, Vandana, Stefanovic, Vedran, Goodnight, William, Blumenfeld, Yair, Mustafa, Hiba J., Sambatur, Enaja V., Shamshirsaz, Alireza A., Johnson, Sonia, Moise, Kenneth J., Jr., Baschat, Ahmet A., (Joanne) Verweij, E.J.T., Javinani, Ali, Kilby, Mark D., and Snowise, Saul

Published
2024
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15. Study protocol for two randomised controlled trials evaluating the effects of Cerclage in the reduction of extreme preterm birth and perinatal mortality in twin pregnancies with a short cervix or dilatation: the TWIN Cerclage studies

Author

van Gils, Lissa, primary, de Boer, Marjon A, additional, Bosmans, Judith, additional, Duijnhoven, Ruben, additional, Schoenmakers, Sam, additional, Derks, Jan B, additional, Prins, Jelmer R, additional, Al-Nasiry, Salwan, additional, Lutke Holzik, Margo, additional, Lopriore, Enrico, additional, van Drongelen, Joris, additional, Knol, Marieke H, additional, van Laar, Judith O E H, additional, Jacquemyn, Yves, additional, van Holsbeke, Caroline, additional, Dehaene, Isabelle, additional, Lewi, Liesbeth, additional, van der Merwe, Hannes, additional, Gyselaers, Wilfried, additional, Obermann-Borst, Sylvia A, additional, Holthuis, Mayella, additional, Mol, Ben W, additional, Pajkrt, Eva, additional, and Oudijk, Martijn A, additional

Published
2024
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16. Study protocol for two randomised controlled trials evaluating the effects of Cerclage in the reduction of extreme preterm birth and perinatal mortality in twin pregnancies with a short cervix or dilatation: The TWIN Cerclage studies

Author

MS Verloskunde, Other research (not in main researchprogram), Van Gils, Lissa, De Boer, Marjon A., Bosmans, Judith, Duijnhoven, Ruben, Schoenmakers, Sam, Derks, Jan B., Prins, Jelmer R., Al-Nasiry, Salwan, Lutke Holzik, Margo, Lopriore, Enrico, Van Drongelen, Joris, Knol, Marieke H., Van Laar, Judith O.E.H., Jacquemyn, Yves, Van Holsbeke, Caroline, Dehaene, Isabelle, Lewi, Liesbeth, Van Der Merwe, Hannes, Gyselaers, Wilfried, Obermann-Borst, Sylvia A., Holthuis, Mayella, Mol, Ben W., Pajkrt, Eva, Oudijk, Martijn A., MS Verloskunde, Other research (not in main researchprogram), Van Gils, Lissa, De Boer, Marjon A., Bosmans, Judith, Duijnhoven, Ruben, Schoenmakers, Sam, Derks, Jan B., Prins, Jelmer R., Al-Nasiry, Salwan, Lutke Holzik, Margo, Lopriore, Enrico, Van Drongelen, Joris, Knol, Marieke H., Van Laar, Judith O.E.H., Jacquemyn, Yves, Van Holsbeke, Caroline, Dehaene, Isabelle, Lewi, Liesbeth, Van Der Merwe, Hannes, Gyselaers, Wilfried, Obermann-Borst, Sylvia A., Holthuis, Mayella, Mol, Ben W., Pajkrt, Eva, and Oudijk, Martijn A.

Published
2024

17. Study protocol for two randomised controlled trials evaluating the effects of Cerclage in the reduction of extreme preterm birth and perinatal mortality in twin pregnancies with a short cervix or dilatation:The TWIN Cerclage studies

Author

Van Gils, Lissa, De Boer, Marjon A., Bosmans, Judith, Duijnhoven, Ruben, Schoenmakers, Sam, Derks, Jan B., Prins, Jelmer R., Al-Nasiry, Salwan, Lutke Holzik, Margo, Lopriore, Enrico, Van Drongelen, Joris, Knol, Marieke H., Van Laar, Judith O.E.H., Jacquemyn, Yves, Van Holsbeke, Caroline, Dehaene, Isabelle, Lewi, Liesbeth, Van Der Merwe, Hannes, Gyselaers, Wilfried, Obermann-Borst, Sylvia A., Holthuis, Mayella, Mol, Ben W., Pajkrt, Eva, Oudijk, Martijn A., Van Gils, Lissa, De Boer, Marjon A., Bosmans, Judith, Duijnhoven, Ruben, Schoenmakers, Sam, Derks, Jan B., Prins, Jelmer R., Al-Nasiry, Salwan, Lutke Holzik, Margo, Lopriore, Enrico, Van Drongelen, Joris, Knol, Marieke H., Van Laar, Judith O.E.H., Jacquemyn, Yves, Van Holsbeke, Caroline, Dehaene, Isabelle, Lewi, Liesbeth, Van Der Merwe, Hannes, Gyselaers, Wilfried, Obermann-Borst, Sylvia A., Holthuis, Mayella, Mol, Ben W., Pajkrt, Eva, and Oudijk, Martijn A.

Abstract

Introduction:Twin pregnancies have a high risk of extreme preterm birth (PTB) at less than 28 weeks of gestation, which is associated with increased risk of neonatal morbidity and mortality. Currently there is a lack of effective treatments for women with a twin pregnancy and a short cervix or cervical dilatation. A possible effective surgical method to reduce extreme PTB in twin pregnancies with an asymptomatic short cervix or dilatation at midpregnancy is the placement of a vaginal cerclage. Methods and analysis: We designed two multicentre randomised trials involving eight hospitals in the Netherlands (sites in other countries may be added at a later date). Women older than 16 years with a twin pregnancy at <24 weeks of gestation and an asymptomatic short cervix of ≤25 mm or cervical dilatation will be randomly allocated (1:1) to both trials on vaginal cerclage and standard treatment according to the current Dutch Society of Obstetrics and Gynaecology guideline (no cerclage). Permuted blocks sized 2 and 4 will be used to minimise the risk of disbalance. The primary outcome measure is PTB of <28 weeks. Analyses will be by intention to treat. The first trial is to demonstrate a risk reduction from 25% to 10% in the short cervix group, for which 194 patients need to be recruited. The second trial is to demonstrate a risk reduction from 80% to 35% in the dilatation group and will recruit 44 women. A cost-effectiveness analysis will be performed from a societal perspective. Ethics and dissemination: This study has been approved by the Research Ethics Committees in the Netherlands on 3/30/2023. Participants will be required to sign an informed consent form. The results will be presented at conferences and published in a peer-reviewed journal. Participants will be informed about the results.

Published
2024

19. Maternal "mirror" syndrome: Evaluating the benefits of fetal therapy.

Author

Sichitiu, Joanna, Alkazaleh, Fawaz, de Heus, Roel, Abbasi, Nimrah, van Mieghem, Tim, Keunen, Johannes, Windrim, Rory, Seaward, Gareth, Kelly, Edmond N., Lewi, Liesbeth, Deprest, Jan, Ryan, Greg, and Shinar, Shiri

Abstract

Objective: To evaluate maternal and perinatal outcomes following fetal intervention in the context of maternal "mirror" syndrome. Study Design: A multicenter retrospective study of all cases of fetal hydrops complicated by maternal "mirror" syndrome and treated by any form of fetal therapy between 1995 and 2022. Medical records and ultrasound images of all cases were reviewed. "Mirror" syndrome was defined as fetal hydrops and/or placentomegaly associated with the maternal development of pronounced edema, with or without pre‐eclampsia. Fetal hydrops was defined as the presence of abnormal fluid collections in ≥2 body cavities. Results: Twenty‐one pregnancies met the inclusion criteria. Causes of fetal hydrops and/or placentomegaly included fetal lung lesions (n = 9), twin‐twin transfusion syndrome (n = 6), severe fetal anemia (n = 4), and others (n = 2). Mean gestational age at "mirror" presentation was 27.0 ± 3.8 weeks. Maternal "mirror" syndrome was identified following fetal therapeutic intervention in 14 cases (66.6%). "Mirror" symptoms resolved or significantly improved before delivery in 8 (38.1%) cases with a mean interval from fetal intervention to maternal recovery of 13.1 days (range 4–35). Three women needed to be delivered because of worsening "mirror" syndrome. Of the 21 pregnancies treated (27 fetuses), there were 15 (55.5%) livebirths, 7 (25.9%) neonatal deaths and 5 (18.5%) intra‐uterine deaths. Conclusion: Following successful treatment and resolution of fetal hydrops, maternal "mirror" syndrome can improve or sometimes completely resolve before delivery. Furthermore, the recognition that "mirror" syndrome may arise only after fetal intervention necessitates hightened patient maternal surveillance in cases of fetal hydrops. Key points: What's already known about this topic? "Mirror" syndrome, where maternal symptoms reflect fetal hydrops, affects 20%–30% of fetal hydrops cases. Case studies show maternal condition improvement following successful fetal therapy. However, comprehensive research to understand fetal therapy's effect on maternal and fetal outcomes is lacking. What does this study add? This study provides new insights into the efficacy of fetal interventions for "mirror" syndrome and, in particular, underscores the importance of patient counseling, given the significant maternal morbidity involved. [ABSTRACT FROM AUTHOR]

Published
2024
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20. In Utero Surgery for Spina Bifida Aperta

Author

Deprest, Jan, Devlieger, Roland, Van Calenbergh, Frank, Devroe, Sarah, Van der Merwe, Hannes, Lewi, Liesbeth, De Catte, Luc, Joyeux, Luc, Nezhat, Ceana H., editor, Kavic, Michael S., editor, Lanzafame, Raymond J., editor, Lindsay, Michael K., editor, and Polk, Travis M., editor

Published
2019
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27. Cardiac adaptation and malformation in twin–twin transfusion syndrome and selective fetal growth restriction: A systematic review.

Author

Noll, Anne T. R., Gijtenbeek, Manon, Verweij, E. J. T, Lewi, Liesbeth, Herling, Lotta, and Haak, Monique C.

Abstract

Objectives: This systematic review explores cardiac adaptation in monochorionic (MC) twins with twin–twin transfusion syndrome (TTTS) or selective fetal growth restriction (sFGR) and assesses the risk of congenital heart defects (CHDs). Methods: Adhering to PRISMA guidelines, 63 studies were reviewed (49 on cardiac adaptation, 13 on CHD, one on both). A narrative synthesis of cardiac adaptation patterns was performed. Additionally, a meta‐analysis compared the livebirth prevalence of CHD in TTTS and sFGR against uncomplicated MC twins. Results: In TTTS recipients, cardiac function may be impaired for diastolic, systolic, as well as global functions, while in donors, cardiac function is generally preserved. In sFGR, large twins may show hypertrophic cardiomyopathy, and small twins may show impaired systolic function. Co‐occurrence of TTTS and sFGR magnifies cardiac impact but is often underreported. Meta‐analysis for CHD prevalence revealed a relative risk ratio of 3.5 (95% CI: 2.5–4.9) for TTTS and 2.2 (95%CI: 1.3–3.5) for sFGR compared with uncomplicated MC twins. Conclusions: This study highlights the well‐documented cardiac adaptation in TTTS, contrasting with limited understanding in sFGR. Elevated CHD risks were observed in both conditions. Enhanced cardiovascular surveillance is warranted in complicated MC twin pregnancies. Future research should explore cardiac adaptation in sFGR and its long‐term consequences. Key points: What is already known about this topic? Existing literature extensively documents that the hemodynamic imbalance in twin–twin transfusion syndrome (TTTS) induces distinct cardiac adaptation in both the recipient and the donor.TTTS twins are more prone to congenital heart disease (CHD) than singletons and uncomplicated monochorionic (MC) twins. What does this review add? Cardiac adaptation also applies to selective fetal growth restricted (sFGR) twins, affecting both the larger and smaller twins, highlighting a crucial, yet underexplored aspect for future studies.TTTS twins are 3.5 times and sFGR twins are 2.2 times more likely to develop structural heart defects than uncomplicated MC twins. [ABSTRACT FROM AUTHOR]

Published
2024
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31. List of Contributors

Author

Afonso, Cláudia, primary, Bandarra, Narcisa M., additional, Bennasar, Mar, additional, Blickstein, Isaac, additional, Cardoso, Carlos, additional, Casati, Daniela, additional, Christensen, Kaare, additional, Corsello, Giovanni, additional, Costello-Harris, Vanessa A., additional, Couck, Isabel, additional, Craig, Jeffrey M., additional, de Ávila, Luísa Moreira, additional, de Carvalho, Paulo Roberto Nassar, additional, de Sá, Renato Augusto Moreira, additional, de Villiers, Suzanne F., additional, Deprest, Jan, additional, Faiola, Stefano, additional, Gijtenbeek, Manon, additional, Graça, Mafalda Gagliardini, additional, Gratacós, Eduard, additional, Haak, Monique, additional, Homfray, Tessa, additional, Jahanfar, Shayesteh, additional, Lanna, Mariano, additional, Leonard, Samantha, additional, Lewi, Liesbeth, additional, Lopes, Jorge, additional, Lopriore, Enrico, additional, Macedo, Miguel Pereira, additional, Martin, Kimberly, additional, Matias, Alexandra, additional, Montenegro, Nuno, additional, Nedelec, Joseph L., additional, Segal, Nancy L., additional, Silva, Sara, additional, Sutton, Emma K., additional, Thinggaard, Mikael, additional, Tollenaar, Lisanne, additional, Verbeek, Lianne, additional, and Werner, Heron, additional

Published
2020
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34. List of Contributors

Author

Acharya, Ganesh, primary, Aertsen, Michael, additional, Afshar, Yalda, additional, Ananth, Cande V., additional, Ashworth, Michael, additional, Au, Patrick, additional, Bakalis, Spyros, additional, Benoist, Guillaume, additional, Bilancia, Colleen G., additional, Bilardo, Caterina M., additional, Bryant, Louise D., additional, Butler, Colin R., additional, Van Calenbergh, Frank, additional, Caritis, Steve N., additional, Chitty, Lyn S., additional, Collins, Patricia, additional, Cook, James, additional, Cuckle, Howard, additional, David, Anna L., additional, De Catte, Luc, additional, De Coppi, Paolo, additional, de Jong-Pleij, Elisabeth, additional, De Keersmaecker, Bart, additional, Deprest, Jan, additional, Devlieger, Roland, additional, de Wert, Guido M., additional, Dickinson, Jan E., additional, Dilworth, Mark, additional, Dondorp, Wybo J., additional, Dunk, Caroline E., additional, Everett, Thomas R., additional, Fisher, Jane, additional, Galan, Henry L., additional, Ganapathi, Mythily, additional, Gardiner, Helena M., additional, Gotherstrom, Cecilia, additional, Harding, Richard, additional, Hewison, Jenny, additional, Hewitt, Richard J., additional, Hiersch, Liran, additional, Hill, Melissa, additional, Hillman, Sara L., additional, Hindryckx, An, additional, Hooper, Stuart B., additional, Huppertz, Berthold, additional, Hutchinson, J. Ciaran, additional, Hyett, Jon, additional, Joyeux, Luc, additional, Jurkovic, Davor, additional, Kingdom, John C., additional, Langlois, Sylvie, additional, Lemon, Lara S., additional, Leruez-Ville, Marianne, additional, Lewi, Liesbeth, additional, Levy, Brynn, additional, Loke, Y.W., additional, Lopriore, Enrico, additional, Macones, George A., additional, Malone, Fergal D., additional, Martirosian, Anahit, additional, McAuliffe, Fionnuala, additional, McDougall, Annie R.A., additional, Moise, Kenneth J., additional, Moffett, Ashley, additional, Müllers, Sieglinde M., additional, Neiger, Ran, additional, Newnham, John P., additional, Obican, Sarah G., additional, Odibo, Anthony O., additional, Oepkes, Dick, additional, Pandya, Pranav P., additional, Platt, Lawrence D., additional, Pratt, Rosalind, additional, Rajah, Kuhan, additional, Rao, Rashmi, additional, Richter, Jute, additional, Rosenbloom, Joshua I., additional, Russo, Francesca Maria, additional, Scialli, Anthony R., additional, Sebire, Neil J., additional, Sharkey, Andrew, additional, Shelmerdine, Susan C., additional, Sibley, Colin, additional, Snowise, Saul, additional, Steggerda, Sylke, additional, Su, Emily J., additional, Tang, Mary, additional, Te Pas, Arjan B., additional, Tita, Alan T., additional, Ushakov, Fred, additional, Van den Veyver, Ignatia B., additional, van Klink, Jeanine M., additional, Venkataramanan, Raman, additional, Ville, Yves, additional, Walkiewicz, Magdalena, additional, Wallis, Colin, additional, Walther-Jallow, Lilian, additional, Wapner, Ronald J., additional, Westgren, Magnus, additional, White, Scott W., additional, Wilson, Louise C., additional, Wilson, R. Douglas, additional, Winkelhorst, Dian, additional, Winyard, Paul J.D., additional, Wohlmuth, Christoph, additional, Wou, Karen, additional, Yaron, Yuval, additional, Leung, Kwok Yin, additional, and Yulia, Angela, additional

Published
2020
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38. In Utero Surgery for Spina Bifida Aperta

Author

Deprest, Jan, primary, Devlieger, Roland, additional, Van Calenbergh, Frank, additional, Devroe, Sarah, additional, Van der Merwe, Hannes, additional, Lewi, Liesbeth, additional, De Catte, Luc, additional, and Joyeux, Luc, additional

Published
2018
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40. Study protocol: developing, disseminating, and implementing a core outcome set for selective fetal growth restriction in monochorionic twin pregnancies

Author

Khalil, Asma, Duffy, James M. N., Perry, Helen, Ganzevoort, Wessel, Reed, Keith, Baschat, Ahmet A., Deprest, Jan, Gratacos, Eduardo, Hecher, Kurt, Lewi, Liesbeth, Lopriore, Enrico, Oepkes, Dick, Papageorghiou, Aris, Gordijn, Sanne J., and On behalf of the International Collaboration to Harmonise Outcomes for Selective Fetal Growth Restriction (CHOOSE-FGR)

Published
2019
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41. Congenital Diaphragmatic Hernia

Author

van Mieghem, Tim, primary, Russo, Francesca Maria, additional, Engels, Alexander, additional, de Catte, Luc, additional, Devlieger, Roland, additional, Lewi, Liesbeth, additional, and Deprest, Jan, additional

Published
2018
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42. Contributors

Author

Abdel-Razeq, Sonya S., primary, Afshar, Yalda, additional, Arigita, Marta, additional, Armstrong, Abigail A., additional, Bahtiyar, Mert Ozan, additional, Baschat, Ahmet, additional, Baumann, Marc U., additional, Bennasar, Mar, additional, Berkowitz, Richard L., additional, Bhide, Amar, additional, Blaas, Harm-Gerd K., additional, Bleich, April T., additional, Bradshaw, Rachael J., additional, Braun, Thorsten, additional, Brewer, Fallon R., additional, Burgess, Angela, additional, Cahill, Alison G., additional, Campbell, Katherine H., additional, Chantraine, Frederic, additional, Chao, Tamara T., additional, Chatterjee, Debnath, additional, Coletta, Jaclyn M., additional, Contro, Elena, additional, Copel, Joshua A., additional, Crispi, Fatima, additional, Crombleholme, Timothy M., additional, Cross, Sarah N., additional, Cruz-Lemini, Mónica, additional, Cruz-Martínez, Rogelio, additional, Dall'Asta, Andrea, additional, D'Alton, Mary E., additional, D'Antonio, Francesco, additional, Dashe, Jodi S., additional, De Catte, Luc, additional, De Musso, Francesca, additional, De Robertis, Valentina, additional, Deprest, Jan, additional, Devlieger, Roland, additional, Diemert, Anke, additional, Drehfal, Lindsey, additional, Eixarch, Elisenda, additional, Engels, Alexander, additional, Evers, Jakob, additional, Fanelli, Tiziana, additional, Feltovich, Helen, additional, Fernández, Susana, additional, Figueras, Francesc, additional, Friedman, Perry, additional, Frusca, Tiziana, additional, Fuchs, Karin M., additional, Gainer, Julie A., additional, Galerneau, France, additional, Gaw, Stephanie L., additional, Ghartey, Kobina, additional, Ghi, Tullio, additional, Goetzinger, Katherine R., additional, Gómez, Olga, additional, Gratacós, Eduard, additional, Gravino, Carole, additional, Hamel, Maureen S., additional, Han, Christina S., additional, Harper, Lorie M., additional, Henrich, Wolfgang, additional, Hernandez, Jennifer S., additional, Herrera, Mauricio, additional, Heuser, Cara C., additional, Hou, June Y., additional, House, Michael, additional, Howley, Lisa W., additional, Hulinsky, Rebecca S., additional, Hyett, Jon A., additional, Jackson, G. Marc, additional, Jain, Joses A., additional, Johnson, Anthony, additional, Johnson, Clark T., additional, Kainer, Franz, additional, Kalache, Karim D., additional, Kohari, Katherine S., additional, Krakow, Deborah, additional, Lee, Wesley, additional, Lerman-Sagie, Tally, additional, Lewi, Liesbeth, additional, Li, Ling, additional, Lipkind, Heather S., additional, Longman, Ryan E., additional, Louis-Jacques, Adetola F., additional, Maggio, Lindsay, additional, Magriples, Urania, additional, Malinger, Gustavo, additional, Martin, Stephanie, additional, Martinez, Josep M., additional, Marwan, Ahmed I., additional, Merriam, Audrey, additional, Michaelis, Silke A.M., additional, Miller, Jena, additional, Miller, Russell S., additional, Millischer, Anne-Elodie, additional, Monteagudo, Ana, additional, Moroz, Leslie, additional, Mosquera, Claudia, additional, Nayeri, Unzila A., additional, Običan, Sarah, additional, Odibo, Anthony O., additional, Ogunyemi, Dotun, additional, Papageorghiou, Aris T., additional, Park, Felicity J., additional, Pettker, Christian M., additional, Pilu, Gianluigi, additional, Platt, Lawrence D., additional, Puerto, Bienvenido, additional, Quinn, Melissa, additional, Raio, Luigi, additional, Rembouskos, Georgios, additional, Rosado-Mendez, Ivan M., additional, Rossi, Andrea, additional, Russo, Francesca Maria, additional, Salazar, Laura, additional, Salomon, Laurent J., additional, Samuel, Amber, additional, Sanz-Cortés, Magdalena, additional, Sfakianaki, Anna Katerina, additional, Sheffield, Jeanne S., additional, Shelley, Sara, additional, Silasi, Michelle, additional, Silver, Robert, additional, Simpson, Lynn L., additional, Sinkey, Rachel G., additional, Snowise, Saul, additional, Sonigo, Pascale, additional, Stohl, Hindi E., additional, Stupin, Jens H., additional, Timor-Tritsch, Ilan E., additional, Toi, Ants, additional, Too, Gloria, additional, Tutschek, Boris, additional, Tuuli, Methodius G., additional, Van den Veyver, Ignatia B., additional, Van Mieghem, Tim, additional, Vink, Joy, additional, Volpe, Paolo, additional, Votino, Carmela, additional, Walsh, Jennifer M., additional, Werner, Erika F., additional, and Zuckerwise, Lisa C., additional

Published
2018
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44. Subsequent fertility, pregnancy, and gynaecological and psychological outcomes after maternal–fetal surgery for open spina bifida: A prospective cohort study.

Author

Haenen, Kobe, Vergote, Simen, Kunpalin, Yada, De Catte, Luc, Devlieger, Roland, Lewi, Liesbeth, van der Merwe, Johannes, Russo, Francesca, De Vloo, Philippe, Lannoo, Lore, and Deprest, Jan

Subjects
FETAL surgery, SPINA bifida, PREGNANCY, NEURAL tube defects, PLACENTA accreta, LONGITUDINAL method
Abstract

Objective: To determine the medium‐term maternal impact of open fetal spina bifida repair. Design: Prospective cohort study. Setting: University Hospitals Leuven, Belgium. Population: Mothers who had open maternal–fetal spina bifida repair between March 2012 and December 2021. Methods: A patient‐reported survey on subsequent fertility, pregnancy, and gynaecological and psychological outcomes. Main outcome measures: Complications during subsequent pregnancies, and gynaecological and psychological problems. Results: Seventy‐two out of 100 invited women completed the questionnaire (72%). Despite being advised not to, seven of 13 women attempting to conceive became pregnant within 2 years after fetal surgery and one woman delivered vaginally. Two of the 16 subsequent pregnancies were complicated by an open neural tube defect. One pregnancy was complicated by a placenta accreta and one pregnancy was complicated by a uterine rupture, both with good neonatal outcomes. Nearly half of respondents who did not attempt to conceive reported that this was because of their experience of the index pregnancy and caring for the index child. Three out of four respondents reported medium‐term psychological problems, mostly anxiety for the health of the index child, fear for recurrence in subsequent pregnancies and feelings of guilt. Conclusions: Open maternal–fetal surgery for spina bifida did not appear to affect fertility in our cohort. Half of the attempts to conceive took place within 2 years. One uterine rupture and one placenta accreta occurred in 16 subsequent pregnancies. Most respondents reported psychological problems linked to the index pregnancy, which reinforces the need for long‐term psychological support. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Subsequent fertility, pregnancy, gynaecological and psychological outcomes after maternal-fetal surgery for open spina bifida: a prospective cohort study

Author

Haenen, Kobe, primary, Vergote, Simen, additional, Kunpalin, Yada, additional, Catte, Luc De, additional, Devlieger, Roland, additional, Lewi, Liesbeth, additional, Merwe, Johannes Van der, additional, Russo, Francesca, additional, Vloo, Philippe De, additional, Lannoo, Lore, additional, and Deprest, Jan, additional

Published
2023
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46. Consensus protocols for the management of early and late twin-twin-transfusion-syndrome (TTTS), a delphi study

Author

Krispin, Eyal, primary, Javinani, Ali, additional, Odibo, Anthony O., additional, Miller, Jena L., additional, Stirnemann, Julien, additional, Khalil, Asma, additional, Hecher, Kurt, additional, Chmait, Ramen H., additional, Carreras, Elena, additional, Habli, Mounria, additional, Emery, Stephen, additional, Sepúlveda, Gerardo, additional, Kilby, Mark, additional, Lewi, Liesbeth, additional, Otano, Lucas, additional, Zaretsky, Michael V., additional, Sananès, Nicolas, additional, Yinon, Yoav, additional, William, Welsh Alec, additional, Turan, Ozhan M., additional, Bennasar, Mar, additional, Papanna, Ramesha, additional, Slaghekke, Femke, additional, Van Mieghem, Tim, additional, and Shamshirsaz, Alireza, additional

Published
2023
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