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1,032 results on '"Lewalter, Thorsten"'

2. Prevention of cerebral thromboembolism by oral anticoagulation with dabigatran after pulmonary vein isolation for atrial fibrillation: the ODIn-AF trial

Author

Schrickel, Jan Wilko, Beiert, Thomas, Linhart, Markus, Luetkens, Julian A., Schmitz, Jennifer, Schmid, Matthias, Hindricks, Gerhard, Arentz, Thomas, Stellbrink, Christoph, Deneke, Thomas, Bogossian, Harilaos, Sause, Armin, Steven, Daniel, Gonska, Bernd-Dieter, Rudic, Boris, Lewalter, Thorsten, Zabel, Markus, Geisler, Tobias, Schumacher, Burghard, Jung, Werner, Kleemann, Thomas, Luik, Armin, Veltmann, Christian, Coenen, Martin, and Nickenig, Georg

Published
2024
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9. Self-administered intranasal etripamil using a symptom-prompted, repeat-dose regimen for atrioventricular-nodal-dependent supraventricular tachycardia (RAPID): a multicentre, randomised trial

Author

Ip, James E, Jones, Alonzo, Sr, Stambler, Bruce S, Schleinkofer, David E, Winters, Stephen, Lam, Wilson, Goldstein, Robert, Dor, Isaac Dor, Talwar, Sandeep, O'Neill, Padraig G, Koren, Michael J, Beinart, Sean C, Ambati, Srivani, Mazer, Sean P, Kinn, Robert M, Roy, Karine, Manshadi, Ramin, Kuk, Richard, Verma, Aditya, Phelan, Timothy, Stoian, Alexandru A, Ellenbogen, Kenneth, Jayachandran, J Vijay, Connelly, Terence P, Daccarett, Marcos, Gandhi, Gaurang, Mittal, Suneet, Abdel-Wahab, Amir, Augostini, Ralph, Ip, John H, Sorrentino, Denise, Roux, Jean-Francois, Brar, Ramandeep, Khoo, Clarence, Bennett, Matthew, Lo, Eric, Coutu, Benoit, Sterns, Laurence, Greer, Gerald S, Gujja, Pradeep, Gianfagna, Robert A, Swarup, Vijendra, Sogade, Felix, Wilton, Stephen, Ruisi, Christopher, Barbera, Saverio, Banchs, Javier E., Korley, Victoria, Schulze, Christopher, Damle, Roger, Healey, Jeffrey Sean, Pandey, A Shekhar, Anderson, Jeffrey L, Venkatachalam, K L, Noseworthy, Peter, Mondésert, Blandine, Verma, Atul, Friars, Douglas G, Kambur, Thomas R, Lockwood, Evan, Meininger, Glenn, Olsovsky, Greg, Jones Sr, Alonzo, Greer, Gerald, Mehta, Rohit, Akbar, Saleem, Salman, Malik, Rama, Bhola, Arora, Ramesh, Shah, Dhirenkumar, Shah, Rakesh, Cammarata, Michael, Owens, Andrew, Ludington, Katherine, Wharton, Marcus, Bagheri, Michael, Khan, Mohammed, Carr, Kenneth Warren, Siddique, Sultan, Parvathaneni, Sunthosh, Devabhaktuni, Subodh, Mouhaffel, Assad, Mark, George, Di Biase, Luigi, Rangappa, Sunil, Morton, Jared, Yarmohammadi, Hirad, Karim, Amin, Martinez Fleites, Aldo, Nero, Thomas, Shafiq, Qaiser, Pandey, Shekhar, Khaykin, Yaariv, Joza, Jacqueline, Gosselin, Gilbert, Skanes, Allen, Vyselaar, John, Savard, Daniel, Heidbuchel, Hein, Xhaet, Olivier, Catez, Emmanuel, Vijgen, Johan, Godart, Pascal, Casado, Ruben, Mairesse, Georges, Rossenbacker, Tom, Haemers, Peter, Hoffer, Etienne, Hausman, Pierre, Vertes, Andras, Duray, Gabor, Szolnoki, Erzsebet, Csanadi, Zoltan, Lakatos, Ferenc, Alings, Marco, Dorman, Reinhart, Tuininga, Y S, Jansen, W, Velthuis, Sebastiaan, van Bemmel, B, Bech, Gerhard Jan Willem, Pisters, Ron, Valk, Suzanne, Romer, Tjeerd, Luermans, Justin, Beelen, Driek, van Eck, Martijn, Houtgraaf, Jaco, Vet, Thijs, Shellings, Dirk, Oosterhof, T, Miekus, Pawel, Bebenek, Waldemar, Bielecka-Dabrowa, Agata, Gniot, Jacek, Zmuda, Witold, Kasprzak, Michal, Balak, Wojciech, Ptaszynski, Pawel, Nowak, Jacek, Prokopczuk, Janusz, Przybylski, Andrzej, Wozniak-Skowerska, Iwona, Derejko, Pawel, Czarnecka, Danuta, Janas, Adam, Merino Llorens, Jose Luis, Tercedor, Luis, Iniguez Romo, Andres, Ruiz Granell, Ricardo, Gonzalez Juanatey, Jose Ramon, Pascual-Figal, Domingo, Martinez-Selles, Manuel, Anguera Camos, Ignacio, Ibanez Criado, Alicia, Matrinez Basterra, Javier, Izquierdo, Alvaro, Rivas Gandara, Nuria, Alegret Colome, Josep M, Perez Diez, Diego, Martínez Hervás, Miguel Ángel, Medina, Maria, Segura Saint-Gerons, Jose María, Pedrote Leal, Alonso, Fernandez Lozano, Ignacio, Quesada, Aurelio, Guerra Ramos, Jose, Sarrias, Axel, Ramos Maqueda, Javier, Mansourati, Jacques, Defaye, Pascal, Guedon-Moreau, Laurence, Milhem, Antoine, De Guillebon, Maxime, Chevalier, Philippe, Badoz, Marc, Kriatselis, Charalampos, Simonis, Gregor, Lewalter, Thorsten, Zarse, Markus, Wilke, Andreas, Kraemer, Fabian, Al-Zoebi, Ayham, Camm, A John, Dorian, Paul, Kowey, Peter R, Merino, Jose L, Piccini, Jonathan P, Pokorney, Sean D, Sager, Philip T, Wharton, J Marcus, Bharucha, David B, Plat, Francis, Shardonofsky, Silvia, and Chen, Michael

Published
2023
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15. Expert opinion on design and endpoints for studies on catheter ablation of atrial fibrillation.

Author

Lewalter, Thorsten, Blomström‐Lundqvist, Carina, Lakkireddy, Dhanunjaya, Packer, Douglas, Meyer, Ralf, Kuniss, Malte, Ladwig, Karl‐H., Jilek, Clemens, Diener, Hans‐C., Boriani, Giuseppe, Turakhia, Mintu P., Schneider, Steffen, Svennberg, Emma, Albers, Bert, Andrade, Jason G., de Melis, Mirko, and Brachmann, Johannes

Subjects
*MEDICAL protocols, *DOCUMENTATION, *PATIENT selection, *RESEARCH funding, *MEDICAL personnel, *ABLATION techniques, *CLINICAL trials, *EXPERIMENTAL design, *ARRHYTHMIA, *DISCUSSION, *ATRIAL fibrillation, *RESEARCH methodology, *CATHETER ablation, *EXPERTISE, RESEARCH evaluation
Abstract

Introduction: Catheter ablation of atrial fibrillation (AF) is frequently studied in randomized trials, observational and registry studies. The aim of this expert opinion is to provide guidance for clinicians and industry regarding the development of future clinical studies on catheter ablation of AF, implement lessons learned from previous studies, and promote a higher degree of consistency across studies. Background: Studies on catheter ablation of AF may benefit from well‐described definitions of endpoints and consistent methodology and documentation of outcomes related to efficacy, safety and cost‐effectiveness. The availably of new, innovative technologies warrants further consideration about their application and impact on study design and the choice of endpoints. Moreover, recent insights gained from AF ablation studies suggest a reconsideration of some methodological aspects. Methods: A panel of clinical experts on catheter ablation of AF and designing and conducting clinical studies developed an expert opinion on the design and endpoints for studies on catheter ablation of AF. Discussions within the expert panel with the aim to reach consensus on predefined topics were based on outcomes reported in the literature and experiences from recent clinical trials. Results: A comprehensive set of recommendations is presented. Key elements include the documentation of clinical AF, medication during the study, repeated ablations and their effect on endpoint assessments, postablation blanking and the choice of rhythm‐related and other endpoints. Conclusion: This expert opinion provides guidance and promotes consistency regarding design of AF catheter ablation studies and identified aspects requiring further research to optimize study design and methodology. Recent insights from studies on catheter ablation of atrial fibrillation (AF) and the availability of new innovative technologies warrant reconsideration of methodological aspects related to study design and the choice and assessment of endpoints. This expert opinion, developed by clinical experts on catheter ablation of AF provides a comprehensive set of recommendations related to these methodological aspects. The aim of this expert opinion is to provide guidance for clinicians and industry regarding the development of clinical studies, implement lessons learned from previous studies, and promote a higher degree of consistency across studies. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Catheter‐based ablation to improve outcomes in patients with atrial fibrillation and heart failure with preserved ejection fraction: Rationale and design of the CABA‐HFPEF‐DZHK27 trial.

Author

Parwani, Abdul S., Kääb, Stefan, Friede, Tim, Tilz, Roland Richard, Bauersachs, Johann, Frey, Norbert, Hindricks, Gerhard, Lewalter, Thorsten, Rienstra, Michiel, Rillig, Andreas, Scherr, Daniel, Steven, Daniel, Kirchhof, Paulus, and Pieske, Burkert

Subjects
ACUTE coronary syndrome, HEART failure patients, CATHETER ablation, MEDICAL care, HEART failure
Abstract

Aims: Atrial fibrillation (AF) is common in heart failure (HF) and negatively impacts outcomes. The role of ablation‐based rhythm control in patients with AF and HF with preserved (HFpEF) or mildly reduced ejection fraction (HFmrEF) is not known. The CABA‐HFPEF‐DZHK27 (CAtheter‐Based Ablation of atrial fibrillation compared to conventional treatment in patients with Heart Failure with Preserved Ejection Fraction) trial will determine whether early catheter ablation for AF can prevent adverse cardiovascular outcomes in patients with HFpEF or HFmrEF. Methods: CABA‐HFPEF‐DZHK27 (NCT05508256) is an investigator‐initiated, prospective, randomized, open, interventional multicentre strategy trial with blinded outcome assessment. Approximately 1548 patients with paroxysmal or persistent AF diagnosed within 24 months prior to enrolment and HFpEF or HFmrEF will be randomized to early catheter ablation within 4 weeks after randomization or to usual care. All patients receive anticoagulation, rate control, and HF management according to current guideline recommendations. Usual care can include rhythm control in symptomatic patients. Patients will be followed until the end of the trial for the primary outcome, a composite of cardiovascular death, stroke, and total unplanned hospitalizations for HF or acute coronary syndrome. The safety outcome comprises complications of catheter ablation and death. The trial is powered for a rate ratio of 0.75 (two‐sided alpha = 0.05, 1‐beta = 0.8). Conclusion: CABA‐HFPEF‐DZHK27 will define the role of systematic and early catheter ablation in patients with AF and HFpEF or HFmrEF. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Concise guidelines of the European Cardiac Arrhythmias Society (ECAS) on “catheter ablation of atrial fibrillation”: A prepublication of the methods in preparation of the final guidelines document

Author

Cappato, Riccardo, primary, Levy, Samuel, additional, Providencia, Rui, additional, Ali, Hussam, additional, Ardashev, Andrey, additional, Barra, Sergio, additional, Creta, Antonio, additional, Farkowski, Michal, additional, Heeger, Christian‐Hendrick, additional, Kanagaratnam, Prapa, additional, Lewalter, Thorsten, additional, Magnani, Silvia, additional, Shah, Dipen, additional, and Schilling, Richard, additional

Published
2024
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22. Comparison in Patients < 75 Years of Age - Versus – Those > 75 Years on One-year-Events With Atrial Fibrillation and Left Atrial Appendage Occluder (From the Prospective Multicenter German LAARGE Registry)

Author

Nasasra, Aref El, Brachmann, Johannes, Lewalter, Thorsten, Akin, Ibrahim, Sievert, Horst, Nienaber, Christoph A., Weiß, Christian, Pleger, Sven T., Ince, Hüseyin, Maier, Jens, Achenbach, Stephan, Sigusch, Holger H., Hochadel, Matthias, Schneider, Steffen, Senges, Jochen, and Zeymer, Uwe

Published
2020
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23. Influence of Meteorological Parameters on the Prevalence of TEE Detected Left Atrial Appendage Thrombi.

Author

Lecker, Franziska, Tiemann, Klaus, Lewalter, Thorsten, and Jilek, Clemens

Subjects
TRANSESOPHAGEAL echocardiography, LEFT heart atrium, ATMOSPHERIC pressure, ISCHEMIC stroke, HUMIDITY
Abstract

(1) Background: Meteorological factors seem to exert various effects on human health, influencing the occurrence of diseases such as thromboembolic events and strokes. Low atmospheric pressure in summer may be associated with an increased likelihood of ischemic stroke. The aim of this study was to investigate the potential impact of meteorological conditions on left atrial appendage (LAA) thrombus formation. (2) Methods: A total of 131 patients were included, diagnosed with a first instance of thrombus via 3D transesophageal echocardiography (TEE) between February 2009 and February 2019. Months with frequent thrombus diagnoses of at least 10 thrombi per month were categorized as frequent months (F-months), while months with fewer than 10 thrombus diagnoses per month were labelled as non-frequent months (N-months). The analysis focused on differences in meteorological parameters in two-week and four-week periods before the diagnosis. (3) Results: F-months were predominantly observed in spring and summer (April, May, June, and July), as well as in February and November. During F-months, a higher absolute temperature difference, lower relative humidity, longer daily sunshine duration, and greater wind speed maximum were observed in the two- and four-week periods rather than for N-months. In the two-week period, average temperatures, equivalent temperatures, and temperature maxima were also significantly higher during F-months than N-months. (4) Conclusion: Thrombi in the left atrial appendage are more prevalent during periods characterized by high absolute temperature differences, low relative humidity, and long daily sunshine duration. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Influence of Heart Rate and Change in Wavefront Direction through Pacing on Conduction Velocity and Voltage Amplitude in a Porcine Model: A High-Density Mapping Study.

Author

Wilhelm, Theresa Isabelle, Lewalter, Thorsten, Reiser, Judith, Werner, Julia, Keil, Andreas, Oesterlein, Tobias, Gleirscher, Lukas, Tiemann, Klaus, and Jilek, Clemens

Subjects
*HEART beat, *CARDIAC pacing, *RIGHT heart atrium, *VOLTAGE, *VELOCITY
Abstract

Background: Understanding the dynamics of conduction velocity (CV) and voltage amplitude (VA) is crucial in cardiac electrophysiology, particularly for substrate-based catheter ablations targeting slow conduction zones and low voltage areas. This study utilizes ultra-high-density mapping to investigate the impact of heart rate and pacing location on changes in the wavefront direction, CV, and VA of healthy pig hearts. Methods: We conducted in vivo electrophysiological studies on four healthy juvenile pigs, involving various pacing locations and heart rates. High-resolution electroanatomic mapping was performed during intrinsic normal sinus rhythm (NSR) and electrical pacing. The study encompassed detailed analyses at three levels: entire heart cavities, subregions, and localized 5-mm-diameter circular areas. Linear mixed-effects models were used to analyze the influence of heart rate and pacing location on CV and VA in different regions. Results: An increase in heart rate correlated with an increase in conduction velocity and a decrease in voltage amplitude. Pacing influenced conduction velocity and voltage amplitude. Pacing also influenced conduction velocity and voltage amplitude, with varying effects observed based on the pacing location within different heart cavities. Pacing from the right atrium (RA) decreased CV in all heart cavities. The overall CV and VA changes in the whole heart cavities were not uniformly reflected in all subregions and subregional CV and VA changes were not always reflected in the overall analysis. Overall, there was a notable variability in absolute CV and VA changes attributed to pacing. Conclusions: Heart rate and pacing location influence CV and VA within healthy juvenile pig hearts. Subregion analysis suggests that specific regions of the heart cavities are more susceptible to pacing. High-resolution mapping aids in detecting regional changes, emphasizing the substantial physiological variations in CV and VA. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Cardiovascular Therapies Targeting Left Atrial Appendage

Author

Turagam, Mohit K., Velagapudi, Poonam, Kar, Saibal, Holmes, David, Reddy, Vivek Y., Refaat, Marwan M., Di Biase, Luigi, Al-Ahmed, Amin, Chung, Mina K., Lewalter, Thorsten, Edgerton, James, Cox, James, Fisher, John, Natale, Andrea, and Lakkireddy, Dhanunjaya R.

Published
2018
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45. Self-administered intranasal etripamil using a symptom-prompted, repeat-dose regimen for atrioventricular-nodal-dependent supraventricular tachycardia (RAPID): a multicentre, randomised trial

Author

Stambler, Bruce S, primary, Camm, A John, additional, Alings, Marco, additional, Dorian, Paul, additional, Heidbuchel, Hein, additional, Houtgraaf, Jaco, additional, Kowey, Peter R, additional, Merino, Jose L, additional, Mondésert, Blandine, additional, Piccini, Jonathan P, additional, Pokorney, Sean D, additional, Sager, Philip T, additional, Verma, Atul, additional, Wharton, J Marcus, additional, Bharucha, David B, additional, Plat, Francis, additional, Shardonofsky, Silvia, additional, Chen, Michael, additional, Ip, James E, additional, Jones, Alonzo, additional, Stambler, Bruce S, additional, Schleinkofer, David E, additional, Winters, Stephen, additional, Lam, Wilson, additional, Goldstein, Robert, additional, Dor, Isaac Dor, additional, Talwar, Sandeep, additional, O'Neill, Padraig G, additional, Koren, Michael J, additional, Beinart, Sean C, additional, Ambati, Srivani, additional, Mazer, Sean P, additional, Kinn, Robert M, additional, Roy, Karine, additional, Manshadi, Ramin, additional, Kuk, Richard, additional, Verma, Aditya, additional, Phelan, Timothy, additional, Stoian, Alexandru A, additional, Ellenbogen, Kenneth, additional, Jayachandran, J Vijay, additional, Connelly, Terence P, additional, Daccarett, Marcos, additional, Gandhi, Gaurang, additional, Mittal, Suneet, additional, Abdel-Wahab, Amir, additional, Augostini, Ralph, additional, Ip, John H, additional, Sorrentino, Denise, additional, Roux, Jean-Francois, additional, Brar, Ramandeep, additional, Khoo, Clarence, additional, Bennett, Matthew, additional, Lo, Eric, additional, Coutu, Benoit, additional, Sterns, Laurence, additional, Greer, Gerald S, additional, Gujja, Pradeep, additional, Gianfagna, Robert A, additional, Swarup, Vijendra, additional, Sogade, Felix, additional, Wilton, Stephen, additional, Ruisi, Christopher, additional, Barbera, Saverio, additional, Banchs, Javier E., additional, Korley, Victoria, additional, Schulze, Christopher, additional, Damle, Roger, additional, Healey, Jeffrey Sean, additional, Pandey, A Shekhar, additional, Anderson, Jeffrey L, additional, Venkatachalam, K L, additional, Noseworthy, Peter, additional, Friars, Douglas G, additional, Kambur, Thomas R, additional, Lockwood, Evan, additional, Meininger, Glenn, additional, Olsovsky, Greg, additional, Jones Sr, Alonzo, additional, Greer, Gerald, additional, Mehta, Rohit, additional, Akbar, Saleem, additional, Salman, Malik, additional, Rama, Bhola, additional, Arora, Ramesh, additional, Shah, Dhirenkumar, additional, Shah, Rakesh, additional, Cammarata, Michael, additional, Owens, Andrew, additional, Ludington, Katherine, additional, Wharton, Marcus, additional, Bagheri, Michael, additional, Khan, Mohammed, additional, Carr, Kenneth Warren, additional, Siddique, Sultan, additional, Parvathaneni, Sunthosh, additional, Devabhaktuni, Subodh, additional, Mouhaffel, Assad, additional, Mark, George, additional, Di Biase, Luigi, additional, Rangappa, Sunil, additional, Morton, Jared, additional, Yarmohammadi, Hirad, additional, Karim, Amin, additional, Martinez Fleites, Aldo, additional, Nero, Thomas, additional, Shafiq, Qaiser, additional, Pandey, Shekhar, additional, Khaykin, Yaariv, additional, Joza, Jacqueline, additional, Gosselin, Gilbert, additional, Skanes, Allen, additional, Vyselaar, John, additional, Savard, Daniel, additional, Xhaet, Olivier, additional, Catez, Emmanuel, additional, Vijgen, Johan, additional, Godart, Pascal, additional, Casado, Ruben, additional, Mairesse, Georges, additional, Rossenbacker, Tom, additional, Haemers, Peter, additional, Hoffer, Etienne, additional, Hausman, Pierre, additional, Vertes, Andras, additional, Duray, Gabor, additional, Szolnoki, Erzsebet, additional, Csanadi, Zoltan, additional, Lakatos, Ferenc, additional, Dorman, Reinhart, additional, Tuininga, Y S, additional, Jansen, W, additional, Velthuis, Sebastiaan, additional, van Bemmel, B, additional, Bech, Gerhard Jan Willem, additional, Pisters, Ron, additional, Valk, Suzanne, additional, Romer, Tjeerd, additional, Luermans, Justin, additional, Beelen, Driek, additional, van Eck, Martijn, additional, Vet, Thijs, additional, Shellings, Dirk, additional, Oosterhof, T, additional, Miekus, Pawel, additional, Bebenek, Waldemar, additional, Bielecka-Dabrowa, Agata, additional, Gniot, Jacek, additional, Zmuda, Witold, additional, Kasprzak, Michal, additional, Balak, Wojciech, additional, Ptaszynski, Pawel, additional, Nowak, Jacek, additional, Prokopczuk, Janusz, additional, Przybylski, Andrzej, additional, Wozniak-Skowerska, Iwona, additional, Derejko, Pawel, additional, Czarnecka, Danuta, additional, Janas, Adam, additional, Merino Llorens, Jose Luis, additional, Tercedor, Luis, additional, Iniguez Romo, Andres, additional, Ruiz Granell, Ricardo, additional, Gonzalez Juanatey, Jose Ramon, additional, Pascual-Figal, Domingo, additional, Martinez-Selles, Manuel, additional, Anguera Camos, Ignacio, additional, Ibanez Criado, Alicia, additional, Matrinez Basterra, Javier, additional, Izquierdo, Alvaro, additional, Rivas Gandara, Nuria, additional, Alegret Colome, Josep M, additional, Perez Diez, Diego, additional, Martínez Hervás, Miguel Ángel, additional, Medina, Maria, additional, Segura Saint-Gerons, Jose María, additional, Pedrote Leal, Alonso, additional, Fernandez Lozano, Ignacio, additional, Quesada, Aurelio, additional, Guerra Ramos, Jose, additional, Sarrias, Axel, additional, Ramos Maqueda, Javier, additional, Mansourati, Jacques, additional, Defaye, Pascal, additional, Guedon-Moreau, Laurence, additional, Milhem, Antoine, additional, De Guillebon, Maxime, additional, Chevalier, Philippe, additional, Badoz, Marc, additional, Kriatselis, Charalampos, additional, Simonis, Gregor, additional, Lewalter, Thorsten, additional, Zarse, Markus, additional, Wilke, Andreas, additional, Kraemer, Fabian, additional, and Al-Zoebi, Ayham, additional

Published
2023
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46. Is spontaneous echo contrast associated with device-related thrombus or embolic events after left atrial appendage occlusion? - Insights from the multicenter German LAARGE registry

Author

Fastner, Christian, primary, Müller, Claus, additional, Brachmann, Johannes, additional, Lewalter, Thorsten, additional, Akin, Ibrahim, additional, Sievert, Horst, additional, Käunicke, Matthias, additional, Zeymer, Uwe, additional, Hochadel, Matthias, additional, Schneider, Steffen, additional, Senges, Jochen, additional, Erkapic, Damir, additional, and Weiß, Christian, additional

Published
2023
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