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Your search keyword '"Levy, Olivier"' showing total 15 results
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15 results on '"Levy, Olivier"'

1. TOX is a critical regulator of tumour-specific T cell differentiation

Author

Scott, Andrew C., Dündar, Friederike, Zumbo, Paul, Chandran, Smita S., Klebanoff, Christopher A., Shakiba, Mojdeh, Trivedi, Prerak, Menocal, Laura, Appleby, Heather, Camara, Steven, Zamarin, Dmitriy, Walther, Tyler, Snyder, Alexandra, Femia, Matthew R., Comen, Elizabeth A., Wen, Hannah Y., Hellmann, Matthew D., Anandasabapathy, Niroshana, Liu, Yong, Altorki, Nasser K., Lauer, Peter, Levy, Olivier, Glickman, Michael S., Kaye, Jonathan, Betel, Doron, Philip, Mary, and Schietinger, Andrea

Published
2019
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2. Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation

Author

Calippe, Bertrand, Augustin, Sebastien, Beguier, Fanny, Charles-Messance, Hugo, Poupel, Lucie, Conart, Jean-Baptiste, Hu, Shulong J., Lavalette, Sophie, Fauvet, Alexandre, Rayes, Julie, Levy, Olivier, Raoul, William, Fitting, Catherine, Denèfle, Thomas, Pickering, Matthew C., Harris, Claire, Jorieux, Sylvie, Sullivan, Patrick M., Sahel, José-Alain, Karoyan, Philippe, Sapieha, Przemyslaw, Guillonneau, Xavier, Gautier, Emmanuel L., and Sennlaub, Florian

Published
2017
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5. CCR2+ monocytes infiltrate atrophic lesions in age‐related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice

Author

Sennlaub, Florian, Auvynet, Constance, Calippe, Bertrand, Lavalette, Sophie, Poupel, Lucie, Hu, Shulong J., Dominguez, Elisa, Camelo, Serge, Levy, Olivier, Guyon, Elodie, Saederup, Noah, Charo, Israel F., Rooijen, Nico Van, Nandrot, Emeline, Bourges, Jean‐Louis, Behar‐Cohen, Francine, Sahel, José‐Alain, Guillonneau, Xavier, Raoul, William, and Combadiere, Christophe

Published
2013
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11. P2rx7 deficiency does not alter subretinal Mononuclear Phagocytes recruitment nor photoreceptor loss 4 days after retinal detachment

Author

Hu, Shulong J, Calippe, Bertrand, Lavalette, Sophie, Roubeix, Christophe, Montassar, Fadoua, Housset, Michael, Levy, Olivier, Delarasse, Cecile, Paques, Michel, Sahel, José-Alain, Sennlaub, Florian, Guillonneau, Xavier, Institut de la Vision, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Guillonneau, Xavier

Subjects
[SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs, sense organs, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, supplementary data
Abstract

Referenced in J Neurosci as URL; To investigate whether P2rx7 inhibition prevented photoreceptor toxicity of C57BL/6J-Mononucelar phagocytes (MPs), we submitted C57BL/6J and P2rx7-/- mice to experimental retinal detachment, where subretinal C57BL/6J-MPs have been shown to participate in photoreceptor degeneration (Nakazawa et al., 2007). C57BL/6J and P2rx7-/- mice exhibit similar subretinal MP accumulation but showed no difference in the number of TUNEL positive photoreceptor cells under these conditions.

Published
2015

13. Erratum to: Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages

Author

Camelo, Serge, primary, Raoul, William, additional, Lavalette, Sophie, additional, Calippe, Bertrand, additional, Cristofaro, Brunella, additional, Levy, Olivier, additional, Houssier, Marianne, additional, Sulpice, Eric, additional, Jonet, Laurent, additional, Klein, Christophe, additional, Devevre, Estelle, additional, Thuret, Gilles, additional, Duarte, Antonio, additional, Eichmann, Anne, additional, Leconte, Laurence, additional, Guillonneau, Xavier, additional, and Sennlaub, Florian, additional

Published
2012
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14. Upregulation of P2RX7 in Cx3cr1-Deficient Mononuclear Phagocytes Leads to Increased Interleukin-1β Secretion and Photoreceptor Neurodegeneration.

Author

Hu, Shulong J., Calippe, Bertrand, Lavalette, Sophie, Roubeix, Christophe, Montassar, Fadoua, Housset, Michael, Levy, Olivier, Delarasse, Cecile, Paques, Michel, Sahel, José-Alain, Sennlaub, Florian, and Guillonneau, Xavier

Subjects
MACROPHAGES, INTERLEUKIN-1, PHOTORECEPTORS, NEURODEGENERATION, AGE factors in retinal degeneration, ENCEPHALITIS
Abstract

Photoreceptor degeneration in age-related macular degeneration (AMD) is associated with an infiltration and chronic accumulation of mononuclear phagocytes (MPs). We have previously shown that Cx3cr1-deficient mice develop age- and stress- related subretinal accumulation of MPs, which is associated with photoreceptor degeneration. Cx3cr1-deficient MPs have been shown to increase neuronal apoptosis through IL-1β in neuroinflammation of the brain. The reason for increased IL-1β secretion from Cx3cr1-deficient MPs, and whether IL-1β is responsible for increased photoreceptor apoptosis in Cx3cr1-deficient mice, has not been elucidated. Here we show that Cx3cr1-deficient MPs express increased surface P2X7 receptor (P2RX7), which stimulates IL-1β maturation and secretion. P2RX7 and IL-1β inhibition efficiently blunted Cx3cr1-MP-dependent photoreceptor apoptosis in a monocyte/retina coculture system and in lightinduced subretinal inflammation of Cx3cr1-deficient mice in vivo. Our results provide an explanation for increased CX3CR1-dependent IL-1β secretion and suggest that IL-1β or P2RX7 inhibition can help inhibit the inflammation-associated photoreceptor cell loss in late AMD, including geographic atrophy, for which no efficient treatment currently exists. [ABSTRACT FROM AUTHOR]

Published
2015
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15. CCR2+ monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice.

Author

Sennlaub, Florian, Auvynet, Constance, Calippe, Bertrand, Lavalette, Sophie, Poupel, Lucie, Hu, Shulong J., Dominguez, Elisa, Camelo, Serge, Levy, Olivier, Guyon, Elodie, Saederup, Noah, Charo, Israel F., Rooijen, Nico Van, Nandrot, Emeline, Bourges, Jean‐Louis, Behar‐Cohen, Francine, Sahel, José‐Alain, Guillonneau, Xavier, Raoul, William, and Combadiere, Christophe

Abstract

Atrophic age-related macular degeneration (AMD) is associated with the subretinal accumulation of mononuclear phagocytes (MPs). Their role in promoting or inhibiting retinal degeneration is unknown. We here show that atrophic AMD is associated with increased intraocular CCL2 levels and subretinal CCR2+ inflammatory monocyte infiltration in patients. Using age- and light-induced subretinal inflammation and photoreceptor degeneration in Cx3cr1 knockout mice, we show that subretinal Cx3cr1 deficient MPs overexpress CCL2 and that both the genetic deletion of CCL2 or CCR2 and the pharmacological inhibition of CCR2 prevent inflammatory monocyte recruitment, MP accumulation and photoreceptor degeneration in vivo. Our study shows that contrary to CCR2 and CCL2, CX3CR1 is constitutively expressed in the retina where it represses the expression of CCL2 and the recruitment of neurotoxic inflammatory CCR2+ monocytes. CCL2/CCR2 inhibition might represent a powerful tool for controlling inflammation and neurodegeneration in AMD. [ABSTRACT FROM AUTHOR]

Published
2013
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