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Background: Hereditary angioedema (HAE) is a rare condition marked by swelling episodes in various body parts, including the extremities, upper airway, face, intestinal tract, and genitals. Long-term prophylaxis (LTP), prescribed to control recurring HAE attacks, is integral to its management. Previously, attenuated androgens (AAs) were the only oral LTP options. However, in 2020, berotralstat, an oral plasma kallikrein inhibitor, was approved in the United States. A 2018 survey of adults with HAE type I or type II showed that almost all the patients who used prophylactic HAE medication preferred oral treatment (98%) and felt that it fit their lifestyle better than injectable treatment (96%). Still, guidelines lack consensus on transitioning patients from AAs to alternative oral prophylactic therapy. Objective: This paper aims to share expert insights and patient feedback on transitioning from AAs to berotralstat, an alternative oral prophylactic therapy, from the perspective of clinicians with extensive experience in treating patients with HAE. Methods: A panel of five HAE specialists convened for a virtual half-day roundtable discussion in April 2023. Results: Discussions about transitioning from AAs to berotralstat were prompted by routine consultations, patient inquiries based on independent research, ineffective current treatment, or worsening AA-related adverse effects. For patients who switched from AAs, the physicians reported that the decision was influenced by the alternative therapy's ability to prevent HAE attacks, its safety, and the once-daily administration schedule. All expert panel members identified fewer AA-related adverse effects; better quality of life; and less severe, shorter, and less frequent HAE attacks as clinical or patient goals they hoped to achieve through the treatment switch. Conclusion: The emergence of new, highly specific LTP drugs for HAE calls for the development of comprehensive recommendations and guidelines for transitioning from AAs to alternative oral prophylactic therapy. The expert panel highlighted key factors to consider during the development of such guidelines. [ABSTRACT FROM AUTHOR]

The study of theory is often a daunting and uninviting, if not terrifying, introduction to sociology courses. Most students do not see theory as helpful intellectual hardware that can facilitate understanding, interpretation and construction of social knowledge. This is true not only in theory courses, but also in many sociology courses including introductory classes, Deviance, Race and Ethnicity, Gender, or Political Sociology in which instructors either address grand theories or teach area-specific theories. A theoretical framework is particularly necessary for sociology courses on deviance and criminology. Since many undergraduate students still tend to perceive crime and deviance as solely individualistic behaviors, an instructor must be able to clearly demonstrate how theory can be useful for understanding broader social causes and explanations of crime and deviance. In this paper, the authors describe an active learning technique, originally developed for a two-week intensive Sociology of Deviance course, that promotes enjoyable, stimulating, and applicable engagement with theory by combining a hypothetical case history with lecture, readings, and peer learning and teaching.

Working within a gender relations paradigm, the voluntary same-sex relationships of white, middle-class, middle-aged men are theorized to conform to two separate and distinct patterns; friendship and comradeship. Complicity with both the current manifestation of dominant masculinity as well as the underlying epistemological structure is seen to determine the interactional choices, friendship or comradeship, of men. A Web-based survey is used to gather data from a sample of the target population. Data are analyzed through exploratory and confirmatory factor analysis, multiple regression, and structural equation modeling. Statistical findings support the hypothesis that complicity with hegemonic masculinity tends to predict comradeship while resistance to hegemonic complicity predicts the practice of friendship. Keywords: gender relations paradigm, white/middle-class/middle-aged men, friendship, comradeship, hegemonic masculinity, hegemonic complicity, The voluntary, personal, nonsexual relationships of men with other men are one way in which men do gender (West & Zimmerman, 1987). These relationships, often mistakenly summarized as friendships, have [...]

The results of the research conducted on van der Waals complexes of aniline and 4-aminobenzonitrile with polar solvents formed in a supersonic jet is reported. It also reports the solvatochromism studies of all substituted benzenes and napthalenes.

Anthranilic acid undergoes a geometry changes between its ground and first-excited electronics states. Though both molecules possess a tramolecular hydrogen bond in their ground states, hydrogen bond in salicylic acid is stronger than in authranilic acid and the studies revealed that both systems exhibit similar behavior upon electronic excitation.

It has been possible to observe the wavelength-dependent photochemistry of trans-urocanic acid in the gas phase. Isomerization of trans-urocanic acid to cis-urocanic acid was seen to arise in the S1 electronic excited state.

The spectroscopy and intermolecular electronic energy transfer (EET) process for a series of molecules, 9-anthryl-(CH2)(subscript n) -- 1-naphthyl, n = 1, 3, and 6 (AnN), was researched in a supersonic jet. In the case of A3N and A6N, a face-to-face conformer can be formed in which exchange coupling can be effective in enhancing the EET rate and in A1N.