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RESUMO Introdução: A cirurgia plástica, sempre em busca de resultados cada vez mais expressivo, vem associando às técnicas já consagradas aos novos tempos intraoperatórios. Este trabalho descreve uma técnica cirúrgica para ser associada às ritidoplastias baseada na ressecção da porção lateral do músculo orbicular, seguida pela enxertia do próprio músculo, porém invertido, sobre a área ressecada. Método: Em um período de 5 anos, foram realizadas 54 ritidoplastias associadas a técnica descrita. Resultados: O seguimento no pós-operatório tardio (5 anos) mostrou-se satisfatório com permanente desaparecimento das ritides perioculares por neutralizar as forças exercidas pelo músculo nesta área. Não houve insatisfação por parte dos pacientes. Logo, trata-se de um procedimento com excelentes resultados na resolução das ritides perioculares e na elevação da porção caudal da sobrancelha em relação a orbita. Conclusão: A técnica descrita gera resultados permanentes e satisfatórios. ABSTRACT Introduction: In the continued search for increasingly expressive results, plastic surgeons are combining established techniques with new intraop erative times. This article describes a surgical technique associated with rhytidoplasties based on the resection of the lateral portion of the orbicu laris oculi muscle, followed by grafting the muscle itself, however inverted, on the resected area. Method: In a 5year period, 54 rhytidoplasties associ ated with the described technique were performed. Results: The follow up in the late postoperative period (5 years) was satisfactory, with the per manent disappearance of periocular rhytides due to the neutralization of the forces exerted by the muscle in this area. There was no dissatisfaction on the part of the patients. Consequently, the procedure had excellent re sults in the resolution of periocular rhytides and in lifting the caudal part of the eyebrow in relation to the orbit. Conclusion: The technique described generates permanent and satisfactory results.

O presente estudo teve como objetivo investigar a efetividade do procedimento Matching-to-sample de Identidade (IMTS) ou emparelhamento com o modelo por identidade com estímulos compostos para o ensino de relações condicionais envolvendo diferentes notas musicais apresentadas em sequência. Os estímulos utilizados foram as notas DÓ, FÁ, SI em três diferentes configurações: (A) nota escrita, (B) representação da nota na pauta musical e (C) som da nota tocada no piano. Quatro universitários foram submetidos a pré-testes (A-B, C-A e C-B) e treino de IMTS com os estímulos compostos AB-AB e pós-testes de emergência de relações condicionais (A-B, AC-B, C-A). Por fim, foram realizados outros dois testes. Um deles teve por objetivo avaliar a emergência de relações condicionais entre sequências dos três estímulos auditivos Cs (por exemplo, C1C2C3) e a sequência dos três estímulos visuais Bs correspondentes (por exemplo, B1B2B3). O outro teste verificou se os participantes conseguiriam nomear a sequência de notas tocadas no piano sem apresentação do estímulo visual. A maioria dos participantes apresentou a emergência das relações condicionais envolvendo as sequências de notas musicais. Esses resultados indicam que o procedimento analisado pode ser eficaz para estabelecer relações condicionais emergentes envolvendo notas musicais apresentadas em sequências.Palavras-chave: equivalência, IMTS, estímulos compostos, notas musicais.

RESUMO Introdução: A principal queixa dos pacientes que procuram as clínicas de cirurgia plástica para serem submetidos a rinoplastia é o dorso nasal. A utilização de enxerto cartilaginoso em radix nasal é rotineira e suas indicações habituais são para diminuir o ângulo nasofacial inadequado ou para redefinir o ponto de transição do radix, para alongamento ou encurtamento do nariz. Este trabalho tem o intuito de apresentar a enxertia de cartilagem do radix nasal, com cartilagem fragmentada e introduzida até o radix com seringa. Método: Foi analisado o ato cirúrgico e seu resultado através da revisão de prontuários dos pacientes submetidos ao ato cirúrgico no período de 1/maio/2011 a 1/maio/2013, totalizando 37 casos. Resultados: Em todos os casos, conseguiu-se o resultado planejado de aumento do radix nasal com sucesso. Não foi observada absorção clinicamente detectável do enxerto. Conclusão: A utilização do enxerto de cartilagem fragmentada realizada da forma descrita neste trabalho mostrou-se eficaz para a elevação do radix nasal. ABSTRACT Introduction: The main complaint of patients visiting plastic surgery clinics for rhinoplasty is the nasal dorsum. Cartilage grafts are routinely used in the nasal radix to reduce inappropriate nasofacial angles or redefine the transition point of the radix and then lengthen or shorten the nose. The aim of this study is to present cartilage nasal radix grafts prepared with diced cartilage and introduced to the radix with the aid of a syringe. Method: We evaluated the surgical procedure and the results obtained by analyzing the medical records of 37 patients who underwent this surgery between May 1, 2011 and May 1, 2013. Results: In all cases, we achieved the expected result of successfully increasing the nasal radix. No graft absorption was clinically detected. Conclusion: The use of a diced cartilage graft as described in this study effectively increased the nasal radix.

Purpose This study aims to explore whether the application of a positive food safety (FS) climate reduces the number of FS violations in the hospitality industry. Design/methodology/approach The sample comprised 271 food handlers in six hotels and 12 restaurants in Brazil. FS climate and risk perceptions were evaluated by self-applicable questionnaires. FS violations were evaluated through observations during the workday. Structural equation modeling with partial least squares was used to test four hypotheses. Findings The findings of this study suggest that a positive FS climate reduces the number of FS violations. It was also observed that risk perception moderated the relationship between FS climate and violations. Physical structure was also identified as a predictor of adequate FS practices. Practical implications The results indicate that restaurant owners and managers should invest in actions toward a positive FS climate. Originality/value It is evident that FS climate elements should be evaluated together, providing a better understanding of the organizational climate and FS culture. Additionally, the bi-directional effect of risk perception was discussed, affecting and being affected by adequate FS practices. To the best of authors’ knowledge, this is the first study to model the FS climate in the hospitality sector and discuss the implications.

An abundant population of Ucides cordatus swamp crabs is present at Lameirao Ecological Station (Brazil), a tropical ecosystem man-made with discharges of domestic, industrial and agricultural pollutants. Concentrations of heavy metals in water, sediment and muscle tissues, gills, hepatopancreas and exoskeleton present in crustaceans were analyzed. The results showed variations in the concentrations of all metals according to precipitation, tide and physicochemical factors. This fact possibly influenced the results of bioconcentration (BFC > 1), indicating a tendency of bioaccumulation according to environmental conditions. We also found a high accumulation of metals in female specimens. However, regardless of gender, we found a reduction in metal concentrations in all tissues analyzed during the period of ecdysis. In this study, we highlight the ecological role of U. cordatus in mangrove ecosystems and its importance in transferring pollutants to the upper trophic levels of the mangrove community, and even to man.

The production of Nile tilapia (Oreochromis niloticus) in Brazil exhibits the highest growth rate in the world and represents approximately 45% of the total fish production. The objective of the present study was to assess the risk for human health due the consumption of tilapia farmed in net cages in eight aquaculture parks in Brazil. The concentrations of pesticides (40 compounds), metals (Mn, Ni, Zn, Cd, Pb, and Sn), arsenic, and cyanotoxins (microcystins) were evaluated in 16 fish from each park. Among analyzed pesticides, pyraclostrobin (0.18–0.32 mg/kg) and fenthion (0.0026–0.0037 mg/kg) exhibited values above the limit of quantification in the tilapia from Aracoiaba, Castanhao, and Ilha Solteira. The highest concentrations of As (0.44 μg/g) in fish tissues were found in Juara, Mn (0.21 μg/g) in Castanhao, and Zi (11.5 μg/g) were found in Tres Marias. Furnas and Linhares exhibited the lowest metal concentrations. The estimated daily intake of muscle by the average Brazilian with 70 kg body weight is below the reference dose for all studied metals in all parks. Total free microcystins showed an accumulation pattern (muscle < gill < liver). The highest concentration in muscle was found in Castanhao (1043 μg/kg) samples. The results showed that fish exhibited metal, As, and pesticide tolerable daily intake (TDI) below the limit and pose low risk for human consumption. Otherwise, TDI for microcystins in fish of all studied parks was above the maximum level recommended by the World Health Organization, indicating that there exists a toxicity risk of fish consumption.

O PRESENTE ARTIGO VERSA SOBRE UM PROJETO INTERDISCIPLINAR ELABORADO POR UM GRUPO DE PESQUISA COMPOSTO POR PROFESSORES/AS DA EDUCAÇÃO BÁSICA, DOCENTES DE UMA UNIVERSIDADE FEDERAL E DE UM COLÉGIO UNIVERSITÁRIO, AMBOS SITUADOS NO MUNICÍPIO DE NITERÓI/RJ, BEM COMO MESTRANDOS E DOUTORANDOS EM EDUCAÇÃO DA MESMA INSTITUIÇÃO. O PROJETO FOI DESENVOLVIDO EM 2019, NESTE COLÉGIO, E ENVOLVEU UM GRUPO DE LICENCIANDOS QUE INTEGRAM UM GRUPO DO PROGRAMA DE EDUCAÇÃO TUTORIAL/PET-MEC/SESU, SUA TUTORA E DUAS PROFESSORAS DO ENSINO FUNDAMENTAL I. A INVESTIGAÇÃO TEVE POR OBJETIVO ANALISAR OS CONTORNOS DO PROJETO INTERDISCIPLINAR DESENVOLVIDO, COM FOCO NAS RELAÇÕES ENTRE OS SUJEITOS ENVOLVIDOS, A PARTIR DAS EXPERIÊNCIAS PEDAGÓGICAS VIVENCIADAS. COM ABORDAGEM QUALITATIVA DO TIPO ESTUDO DE CASO, CADA FASE DA PESQUISA ABRANGEU A LEITURA DOS TEXTOS CONCERNENTES ÀS ETAPAS DE ELABORAÇÃO E DESENVOLVIMENTO DO PROJETO, À SELEÇÃO DOS PARTÍCIPES, BEM COMO À ANÁLISE DAS ATAS DAS REUNIÕES REALIZADAS PELOS ENVOLVIDOS. TAMBÉM CONTAMOS COM AS GRAVAÇÕES DAS ENTREVISTAS NARRATIVAS OCORRIDAS DURANTE AS REUNIÕES DO GRUPO DE PESQUISA RESPONSÁVEL POR ESTA INVESTIGAÇÃO. EM SÍNTESE, OS DEPOIMENTOS ANALISADOS APONTAM PARA A CENTRALIDADE DA INDISSOCIABILIDADE DAS RELAÇÕES ENTRE ESCOLA E UNIVERSIDADE, ENTRE ENSINO E PESQUISA COMO ELOS QUE PODEM CONTRIBUIR PARA O DESENVOLVIMENTO ORGÂNICO DAS RELAÇÕES ESTABELECIDAS NO INTERIOR DAS INSTITUIÇÕES ABRANGIDAS, COM FOCO ESPECIAL PARA AS APRENDIZAGENS PROFISSIONAIS.

Rhyzopertha dominica is an insect pest that feeds on a wide variety of grains and stored cereals, producing economical losses. Bioenergetics studies on insects are necessary to eventually plan strategies to reduce pest infestation on stored grains with methods other than insecticides. Modified atmosphere treatments, where insects are exposed to either low O2 or high CO2 concentrations, or both, can be used as alternatives. In this research, R. dominica was subjected to a modified atmosphere environment (MA) consisting of 5% O2 and 10% CO2 for 24 h and was compared with normoxia insects (21% O2 and 0.02% CO2). Mitochondria from the whole insect were isolated and their protein content was analyzed by two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) using OFFGEL Fractionator equipment and 12% polyacrylamide gels electrophoresis (SDS-PAGE). Lactate concentration, cytochrome c oxidase (COX) and ATPase activities were measured. Lactate concentration was 29% higher in R. dominica exposed to MA versus normoxia. 2-D PAGE and LC MS/MS revealed the presence of a heat shock protein (hsp60), an actin fragment, and ATP synthase α and β catalytic subunits. Activity levels of COX and ATPase were reduced by 58 and 59%, respectively, in MA versus normoxia. Therefore, R. dominica may have shifted into a hypo-metabolic state because oxygen intake was insufficient to maintain enzymatic activity. This scenario would ultimately result in a decrease in substrate concentration (oxygen) and a reduction in electron transport chain complex activity. Thus, eventually, this knowledge can be use to develop novel environmentally friendly alternatives to eradicate or reduce pests in stored grains.

Esse estudo analisou as soluções de alunos do Ensino Médio ao resolverem questões de Análise Combinatória apresentadas no Exame Nacional do Ensino Médio (ENEM). O objetivo deste trabalho é investigar de que modo a metodologia de ensino e aprendizagem Análise de Erros pode contribuir para a construção de conhecimentos em Análise Combinatória. Os instrumentos de coleta de dados foram um questionário sobre o perfil do aluno, uma atividade diagnóstica com questões do ENEM abordando os principais conceitos do conteúdo escolar da Análise Combinatória, e uma entrevista clínica. Por meio da metodologia da Análise de Erro, foi possível elaborar uma classificação das respostas dos estudantes na atividade diagnóstica, pela qual foram mapeados os tipos de erros e acertos com relação ao conteúdo. Os resultados mostraram que os participantes da investigação apresentaram maior domínio no uso do Princípio Multiplicativo. As fórmulas de Arranjo e Combinação foram as que mais estiveram relacionadas ao uso incorreto para os cálculos das possibilidades. A metodologia de Análise de Erro contribui para o ensino e aprendizagem da Análise Combinatória na medida em que abre espaço para o aluno rever a sua resolução, refletir sobre ela com a orientação do professor e rever suas estratégias. Este processo pode contribuir com a construção do conhecimento matemático pelo aluno.

O objetivo desse trabalho foi avaliar o efeito da vacinação contra Streptococcus agalactiae na morfometria, bromatologia e análise sensorial de tilápia criada em tanque-rede. Juvenis de tilápia foram criadas em tanque-rede separados em dois grupos: peixes vacinados e não vacinados. Foram coletados 10 peixes de cada grupo em diferentes classes de peso: 400-500, 501-600, 601-700 e 701-800 g. As medidas e pesagens do peixe inteiro e do filé não apresentaram diferença significativa entre os dois grupos. A espessura do filé foi significativamente maior nos peixes não vacinados na faixa de 601-700 g. Não teve diferença significativa nos valores de proteí­­na, lipí­­dio, cinza e umidade entre os peixes dos dois grupos em nenhuma das classes de peso estudada. Para o teste pareado preferência, não houve uma preferência significativa entre peixes não vacinados e vacinados independente da classe de peso analisada. A análise de escala hedônica apontou que os provadores gostaram moderadamente do filé de tilápia independente da classe de peso e de ter sido vacinado ou não. Nas condições experimentais de criação em tanques-rede, tilápias do Nilo vacinados e não vacinados, com peso entre 400 e 800 g, apresentaram caracterí­­sticas morfométricas, bromatológicas e sensoriais semelhantes.

In today’s news deluge, it can often be overwhelming to understand the significance of a news article or verify the facts within. One approach to address this challenge is to identify relevant data so that crucial statistics or facts can be highlighted for the user to easily digest, and thus improve the user’s comprehension of the news story in a larger context. In this paper, we look toward structured tables on the Web, especially the high quality data tables from Wikipedia, to assist in news understanding. Specifically, we aim to automatically find tables related to a news article. For that, we leverage the content and entities extracted from news articles and their matching tables to fine-tune a Bidirectional Transformers (BERT) model. The resulting model is, therefore, an encoder tailored for article-to-table match. To find the matching tables for a given news article, the fine-tuned BERT model encodes each table in the corpus and the news article into their respective embedding vectors. The tables with the highest cosine similarities to the news article in this new representation space are considered the possible matches. Comprehensive experimental analyses show that the new approach significantly outperforms the baselines over a large, weakly-labeled, dataset obtained from Web click logs as well as a small, crowdsourced, evaluation set. Specifically, our approach achieves near 90% accuracy@5 as opposed to baselines varying between 30% and 64%.

The aim of this study was to determine selected molecular biomarkers of iron ore contamination in Epinephelus marginatus. Molecular biomarkers were tested by checking the relative expression of genes involved in oxidative stress, trace element regulation, and cellular damage, by RT-qPCR. Iron ore exposure caused the downregulation of ferroportin (FP) gene expression and a significant upregulation in superoxide dismutase (SOD) and cytochrome P450 1A (CYP1A) genes. Iron ore affects gene expression in E. marginatus liver, indicating that it can potentially induce toxic effects in fish. Moreover, this altered gene expression pattern may be applied in monitoring iron ore contamination in marine environments.

On November 5th, 2015, the Fundão Dam collapsed dumping more than 50 million/m3 of iron ore tailings, enriched with metals, into the Doce River channel. The objective of this study was to evaluate the reproductive biology and histological damage in Astyanax lacustris exposed to the metals from the dam collapse. The study was carried out at Doce River, in Espírito Santo State, Brazil. Monthly samplings were carried out for a year. Astyanax lacustris had multiple spawning: females reproductive peak was in September, October, November, and December; and males between September, October, January, and February. There was a latency in the formation of gonads. For male gonads, it was necessary a 6 cm growth for it to increase from 30% to 50% and 4 cm for female gonads to increase from 40% to 50%. There is a positive correlation between gonad’s concentration of Al and Fe and the rate of histological damage in females. Male gonads had a high rate of immature cells invading the cell lumen (47.36%) and female gonads showed higher frequency of atresia (39.64%). Fish exposed to the contaminated water showed high gonad histological damage. The observed changes can directly influence the organism development and reproduction in the long run, thus affecting A. lacustris population present in the region.

Agradecimentos: The authors would like to thank CAPES – Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Coordination for the Improvement of Higher Education Personnel) in Brazil for the scholarship granted to the first author (process n° 1684391), to grant #403528/2016–0, CNPQ –Conselho Nacional de Desenvolvimento Científico e Tecnologico (National Council for Scientific and Technological Development) in Brazil and grant #2019/10936–0, São Paulo Research Foundation (FAPESP). This study was partially funded by CAPES, financial code 001 Abstract: This study aims to explore whether the application of a positive food safety (FS) climate reduces the number of FS violations in the hospitality industry. The sample comprised 271 food handlers in six hotels and 12 restaurants in Brazil. FS climate and risk perceptions were evaluated by self-applicable questionnaires. FS violations were evaluated through observations during the workday. Structural equation modeling with partial least squares was used to test four hypotheses. The findings of this study suggest that a positive FS climate reduces the number of FS violations. It was also observed that risk perception moderated the relationship between FS climate and violations. Physical structure was also identified as a predictor of adequate FS practices. The results indicate that restaurant owners and managers should invest in actions toward a positive FS climate. It is evident that FS climate elements should be evaluated together, providing a better understanding of the organizational climate and FS culture. Additionally, the bi-directional effect of risk perception was discussed, affecting and being affected by adequate FS practices. To the best of authors’ knowledge, this is the first study to model the FS climate in the hospitality sector and discuss the implications COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP Fechado

Introduction: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by slow and progressive loss of cognition, which affects mostly elderly people, its prevalence and disabling outcome promote a strong financial impact. Objectives: To present the profile of expenses with hospitalizations by the AD in São Paulo (SP), between 2011 and 2020, through the morbidity list of the CID10-G30, correlating with the character of care, average length of stay, values of professional and hospital services and average value for hospitalizations. Design and setting: This is an ecological, descriptive, retrospective and quantitative study. Methods: Data were collected in the Hospital Information System of the Unified Health System (SIH-SUS). Results: In SP, between 2011 and 2020, there were 4126 admissions for AD, with a predominance of emergency care (74.5%). Spending for hospitalizations was approximately R $ 7.5 million, hospital services accounted for approximately 91.3% of total costs, while professional services accounted for 8.7%. Elective services had an average stay of 61.7 days and corresponded to 63.1% of total expenses, urgent services had an average stay of 12 days and 36.9% of total expenses. The average value per hospitalization was R $ 1,824.92. Conclusions: More than R $ 7.5 million has been spent on AD in the last decade in SP. Elective care had an average stay five times longer and with the costs for hospital services accounted for most of these expenses.

This paper presents a study about some aspects of the influence of population diversity on the performance of the Differential Evolution technique. In order to accomplish this, the referred algorithm is tested with different benchmark functions widely used in the literature, and the performance results are analyzed and discussed by associating changes in the population diversity with changes in the evolution of the best solution over the generations. The objective of this work is to investigate the pattern of diversity behavior throughout the optimization process through graphs results and, then, evaluate how sensitive is the technique performance when associated with the population diversity behavior. This work can assist the implementation of new operators and strategies, which will permit the Differential Evolution technique to have a better performance.

The Lippia alba essential oil (EO) is a fish anesthetic immiscible in water and commonly used diluted in ethanol. We evaluated the effectiveness of surfactant use with Lippia alba EO in the anesthesia of Oreochromis niloticus, as well as its toxicity in fish and mammals. The EO was extracted by hydrodistillation and the fish were exposed to anesthesia at the concentration of 250 μL/L for 10 min with the surfactants polysorbate 20 (T20), polysorbate 80 (T80), polyethylene glycol (PEG), and ethanol. We also evaluated fish recovery and anesthetic safety margin after exposure for 10, 20, and 30 min. To assess the surfactants’ toxicity in mammals, Mus musculus (mice) received the same treatments by gavage. The main constituents of the Lippia alba EO were linalool (42.36%), geraniol (12.46%), neral (10.7%), and limonene (7.45%). Deeper anesthesia was faster in the T20 (60 ± 2.9 s) and T80 (272 ± 21 s) treatment groups, while recovery time for T80 was longer (596 ± 47 s). All treatments showed a good safety margin, without mortality. The genotoxic effects caused by surfactants in mammals and fish were at similar levels to those found in the ethanol treatment. Therefore, this study demonstrated that the use of surfactants T20 and T80 in Oreochromis niloticus anesthesia presented neither a reduction nor a considerable increase of the toxicity when compared to the commonly used ethanol; however, an increase in anesthetic effectiveness was observed throughout the experiment.

In 2020, the COVID-19 pandemic is the major healthcare concern around the world. The infection is especially severe to those with immune system suppression, including patients with cancer. In order to mitigate the negative effects of COVID-19, guidelines have been developed by societies worldwide to review oncology care during this pandemic time. Neoadjuvant endocrine therapy (NET) is a well-stablished option for hormone positive (HR) HER2 negative breast cancer and showed a positive response in breast conservative surgery with substantially less toxicity. Compared to chemotherapy, the NET cost is lower, and its administration is easier, due to less medical visits. Even with remarkable advantages, NET remains taking less place in treatments than it might have. Periods of humanity crisis, such as World Wars and other pandemics, boosted the development of science and established many treatments, which are currently practiced. New data generated during the COVID-19 outbreak can inspire more trials comparing chemotherapy to endocrine therapy within the neoadjuvant setting. The purpose of this letter is to suggest NET as a safe low toxicity treatment strategy for breast cancer, not only to postpone breast cancer surgery during the pandemic, but also to become a standard therapy, a flame kept burning crossing the COVID-19 border.

Orientador: Diogo Thimoteo da Cunha Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos Resumo: O objetivo desse estudo foi avaliar a interação dos elementos constituintes do conceito da cultura de segurança dos alimentos (Cultura de SA) com o risco sanitário em serviços de alimentação. O estudo caracteriza-se como transversal e foi dividido em três etapas. Na primeira etapa, o foco principal foi a compreensão das percepções de risco dos consumidor e manipuladores de alimentos frente às características dos restaurantes. A segunda etapa foi uma análise exploratória dos elementos da Cultura de SA em restaurantes de diferentes perfis sanitários. A terceira etapa foi a proposição de um modelo inferencial do clima de segurança dos alimentos (Clima de SA), visando analisar a relação entre os elementos formativos do Clima de SA e o número de violações em segurança dos alimentos em restaurantes. Participaram do estudo 265 consumidores, 63 gestores, 333 manipuladores de 32 restaurantes na região metropolitana de Campinas, SP ¿ Brasil. Foram avaliados os elementos da Cultura de SA (considerando as rotas tecno-gerenciais e humanas), sendo eles: sistemas de gestão, estilos e processo; ambiente de trabalho; liderança; comunicação; comprometimento; e julgamentos de riscos, sendo incluídas, ainda, a pressão normativa e do trabalho. Neste modelo as percepções de riscos dos manipuladores foram avaliadas como uma variável individual. Esses elementos foram avaliados por meio de questionários específicos validados. Na rota técnico-gerencial, os restaurantes foram categorizados como restaurantes de baixo risco (RBR) e restaurantes de alto risco (RAR) para ocorrência de doenças transmitidas por alimentos (DTA), com base na aplicação de uma lista de verificação validada. Um questionário estruturado foi empregado para avaliar o conhecimento sobre segurança dos alimentos e a percepção de risco de DTA por consumidores, manipuladores de alimentos e gestores. Na primeira etapa, tanto os manipuladores de alimentos quanto os consumidores declararam que estavam menos sujeitos a DTA do que seus pares. No caso dos consumidores, um risco semelhante foi atribuído tanto à preparação de suas próprias refeições quanto às refeições realizadas nos restaurantes em que foram entrevistados, não apresentando viés otimista para este caso. Isso mostra que eles incorporaram um sentimento de carinho e identidade ao local, que corresponde ao sentimento de fazer suas próprias refeições em casa. Na segunda etapa, os RBR apresentaram maior maturidade da Cultura de SA com menor risco sanitário, estrutura física mais adequada, melhor comprometimento organizacional e rotas congruentes com o clima de SA, sendo favorecidas as práticas adequadas de higiene. Na terceira etapa, foi elaborado um modelo em equação estruturada. Foi observado que o Clima de SA reduz o número de violações das boas práticas em restaurantes como também que a percepção de risco apresenta um efeito moderador na relação entre clima de SA e as violações das boas práticas. Quanto maior era a percepção de risco, maior era o efeito do clima sobre as violações. Os resultados demonstraram que aprimorar o clima de SA é uma estratégia eficaz para melhorar a segurança dos alimentos. Com base nos resultados, é possível afirmar que há a necessidade de intervenções eficazes no âmbito da segurança dos alimentos, visto que o consumidor confia nos serviços de alimentação que frequenta, logo, pode ser menos cuidadoso em suas práticas. Além disso, foi observado que a Cultura de SA e o Clima de SA relacionam-se com as práticas adequadas e seguras na manipulação de alimentos Abstract: This study aimed to evaluate the interaction of the food safety culture (FSC) with the risk of foodborne diseases (FBD) in food services. The study is characterized as cross-sectional and was divided into three stages. In the first stage, the focus was on the understanding of consumer risk perceptions regarding the characteristics of restaurants. The second stage was an exploratory analysis of the elements of the FSC in restaurants with different health profiles. The third step was the proposal of an inferential model of the food safety climate, reducing the number of violations of good practices. In total, 265 consumers, 63 managers, 333 handlers from 32 restaurants in the metropolitan region of Campinas, SP - Brazil participated in the study. The elements of the FSC were evaluated (considering the techno-managerial and human routes), which are: management systems, styles and process; Desktop; leadership; Communication; commitment; and risk perceptions, including regulatory and labor pressure. These elements were assessed through specific questionnaires. On the technical-managerial route, restaurants were categorized as low-risk restaurants (RBR) and high-risk restaurants (RAR) by foodborne diseases (FBD) based on the application of a validated checklist. A structured questionnaire was used to assess knowledge about food safety and the perception of risk of FBD by consumers, food handlers, and managers. In the first stage, both food handlers and consumers declared that they were less subject to FBD than their peers. In the case of consumers, a similar risk was attributed both to the preparation of their meals and to lunch and dinner in the restaurants where they were interviewed, with no optimistic bias in this case. This shows that they incorporated a feeling of affection and identity to the place, corresponding to making their meals at home. In step two, the RBRs showed greater maturity of the FSC with less health risk, more adequate physical structure, higher job satisfaction, better organizational commitment, and FSC congruent with the technical-managerial and human route. It was observed that when the elements of the FSC are well structured in food services, factors such as commitment, job satisfaction, and the FSC are more satisfactory for proper hygiene practices. In step three, a structured equation model was developed. It was observed that the food safety climate reduces the number of violations of good practices in restaurants. It was also observed that the perception of risk has a moderating effect on the relationship between SA climate and violations of good practices. The higher the perception of risk, the higher the effect of the food safety climate on violations. The results demonstrate that improving the food safety climate is an effective strategy to improve food safety. Based on the results, it is possible to state that there is a need for effective interventions in the area of food safety since the consumer trusts the food services he/she attends he/she may be less careful in his/her practices. Besides, it was observed that FSC and SA climate is related to adequate and safe practices in food handling Doutorado Consumo e Qualidade de Alimentos Doutor em Alimentos e Nutrição CAPES 1684391 CNPQ 403528/2016-0