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14 results on '"Levkovskiĭ AV"'

2. [Multiple complications of closed injury of the pancreas].

Author

Kukuruza IuP, Levkovskiĭ AV, and Kadoshchuk TA

Subjects
Child, Drainage, Duodenal Obstruction etiology, Duodenal Obstruction surgery, Humans, Male, Pancreatic Cyst etiology, Pancreatic Cyst surgery, Pancreatitis etiology, Pancreatitis surgery, Peritonitis etiology, Peritonitis surgery, Pancreas injuries, Wounds, Nonpenetrating
Published
1990

6. [Inhibition of the binding and activation of the first component of human complement. The effect of synthetic peptides, immunoglobulin fragments and various proteins].

Author

Kozlov LV, Sizoĭ MN, Zinchenko AA, and Levkovskiĭ AV

Subjects
Amino Acid Sequence, Animals, Binding Sites, Binding, Competitive drug effects, Complement Activating Enzymes antagonists & inhibitors, Complement Activating Enzymes immunology, Complement C1q, Dipeptides chemical synthesis, Dipeptides pharmacology, Erythrocytes immunology, Humans, In Vitro Techniques, Kinetics, Oligopeptides chemical synthesis, Oligopeptides pharmacology, Peptides chemical synthesis, Sheep, Stereoisomerism, Complement Activating Enzymes metabolism, Complement Activation drug effects, Complement Inactivator Proteins pharmacology, Immunoglobulin Fc Fragments immunology, Immunoglobulin Fragments immunology, Peptides pharmacology
Abstract

A study has been carried out on the inhibition of the subcomponent Clq binding to sensitized sheep erythrocytes (EA) by the following synthetic peptides mimicking the structure of a putative complement binding site of immunoglobulin G: Boc-Trp-Tyr, Boc-Tyr-Trp, Trp-Tyr, Boc-Trp-Phe, Boc-D-Trp-D-Tyr, Boc-D-Tyr-D-Trp, Boc-Leu-Leu, Ac-Phe-Tyr, and commercial Thr-Lys-Pro-Arg (tuftsin). Boc-Trp-Tyr was found to be the most potent inhibitor of Clq binding to EA (Ki 2.86 X 10(-4) M), tuftsin ranking second with Ki 6 X 10(-4) M. The D,D-dipeptides failed to inhibit the Clq binding at the investigated concentrations. Insoluble Z-Trp-Tyr-OMe activated a classical pathway of complement system, as monitored by consumption of C4, C2 and C3 components. Synthetic octapeptide Boc-Glu-Val-Asp-Leu-Leu-Lys-Asp-Glu-OMe (corresponding to the sequence 36-43 of beta 2-microglobulin) inhibited the Clq binding with Ki 4.7 X 10(-4) M, which gave grounds for localizing the complement binding site in beta 2-microglobulin. The finding in the Clq structure of the peptide sequence homologous to than of the pepsin active site, as well as the close similarity in the specificity of these proteins towards hydrophobic amino acid residues justified the assumption on the same structural bases of their specificity. The results of the present study, along with the literature data, underlie the hypothesis on the involvement in the complement binding of the following IgG residues: Trp277, Tyr278, Lys320, Lys322, Glu318 and Lys290. The enlisted residues are closely located in the three-dimensional structure of the CH2 domain of IgG. Lysozyme and lactalbumin having the sequences homologous to Trp277-Tyr278 of IgG inhibited Clq binding to EA with Ki 3 and 1.5 microM respectively.

Published
1986

8. [Clinical aspects and operative treatment of complicated peptic ulcer in children].

Author

Nechiporuk VM and Levkovskiĭ AV

Subjects
Adolescent, Child, Duodenal Ulcer complications, Duodenal Ulcer surgery, Female, Humans, Male, Peptic Ulcer complications, Pyloric Stenosis etiology, Pyloric Stenosis surgery, Stomach Ulcer complications, Stomach Ulcer surgery, Peptic Ulcer surgery
Abstract

Due to peculiar course of ulcerous process in children, manifested not only by gross morphological changes in the zone of ulcer location but also by profound functional disturbances, it is recommended to resort to surgical interventions prior to the onset of stomach decompensation and development of grave homeostatic disorders. Gastric resection is thought by the authors to be the operation of choice.

Published
1977

13. [Treatment of chronic hematogenic osteomyelitis of the tibia in children].

Author

Sitkovskiĭ NB, Kukuruza IuP, and Levkovskiĭ AV

Subjects
Adolescent, Child, Child, Preschool, Chronic Disease, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Methods, Postoperative Complications, Preoperative Care, Recurrence, Time Factors, Osteomyelitis surgery, Tibia
Published
1973

14. [Staphylococcal destruction of the lungs in children with acute hematogenous osteomyelitis].

Author

Kukuruza IuP, Kievskiĭ II, Kotsiubinskiĭ IuN, Levkovskiĭ AV, and Mazur FP

Subjects
Acute Disease, Child, Child, Preschool, Empyema therapy, Female, Humans, Infant, Infant, Newborn, Male, Osteomyelitis therapy, Pneumonia, Staphylococcal therapy, Empyema etiology, Infant, Newborn, Diseases therapy, Osteomyelitis etiology, Pneumonia, Staphylococcal complications
Published
1972

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