1. Use of right orbitofrontal repetitive transcranial magnetic stimulation (rTMS) augmentation for treatment-refractory obsessive-compulsive disorder with comorbid major depressive disorder
- Author
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Tadayonnejad, Reza, Wilson, Andrew C, Chu, Stephanie Anne, Corlier, Juliana, Citrenbaum, Cole, Ngo, Thuc Doan P, Hovhannisyan, Emmily, Ginder, Nathaniel D, Levitt, Jennifer G, Wilke, Scott A, Krantz, David, Bari, Ausaf A, and Leuchter, Andrew F
- Subjects
Biological Psychology ,Biomedical and Clinical Sciences ,Clinical Sciences ,Psychology ,Assistive Technology ,Depression ,Anxiety Disorders ,Mental Health ,Brain Disorders ,Serious Mental Illness ,Bioengineering ,Rehabilitation ,6.6 Psychological and behavioural ,Evaluation of treatments and therapeutic interventions ,Mental health ,Humans ,Transcranial Magnetic Stimulation ,Depressive Disorder ,Major ,Prefrontal Cortex ,Obsessive-Compulsive Disorder ,Motor Cortex ,Treatment Outcome ,Comorbid OCD-MDD ,rTMS ,Orbitofrontal cortex ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Clinical sciences ,Clinical and health psychology - Abstract
We examined the safety and efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) of the right orbitofrontal cortex (OFC) in patients with refractory obsessive-compulsive disorder (OCD) and comorbid Major Depressive Disorder. All participants (n = 26) received excitatory stimulation of the left dorsolateral prefrontal cortex followed by inhibitory stimulation of bilateral supplementary motor area for 10 sessions. In 18 patients with poor early OCD response, treatment was augmented with OFC inhibitory stimulation after the tenth treatment session. Augmentation with OFC stimulation was well-tolerated, and associated with further alleviation of both OCD and depression symptoms, particularly in individuals with more severe illnesses.
- Published
- 2022