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2. Correlation of Morphological Appearance of Peritoneal Lesions at Laparotomy and Disease at Pathological Assessment in Patients Undergoing Cytoreductive Surgery for Peritoneal Malignancy: Results of Phase I of the PRECINCT Study in 707 Patients

Author

Bhatt, Aditi, Villeneuve, Laurent, Sardi, Armando, Souadka, Amine, Buseck, Alison, Moran, Brendan J., Khannousi, Basma El, de Pedro, Carlos Gonzalez, Baratti, Dario, Biacchi, Danielle, Morris, David, Labow, Daniel, Levine, Edward A., Mohamed, Faheez, Adeleke, Gbadebo, Goswami, Gaurav, Bonnefoy, Isabelle, Perry, Katherine Cummins, Votanopoulos, Konstantinos I., Parikh, Loma, Deraco, Marcello, Alyami, Mohammad, Cohen, Noah, Benzerdjeb, Nazim, Shah, Nehal, Bahaoui, Nezha El, Khajoueinejad, Nazanin, Rousset, Pascal, Shen, Perry, Barat, Shoma, Stanford, Sophia, Khouchoua, Selma, Troob, Samantha, Shaikh, Sakina, Sarpel, Umut, Gushchin, Vadim, Samuel, Vasanth Mark, Kepenekian, Vahan, Sammartino, Paolo, and Glehen, Olivier

Published
2024
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4. ASO Visual Abstract: Correlation of Morphological Appearance of Peritoneal Lesions at Laparotomy and Disease at Pathological Assessment in Patients Undergoing Cytoreductive Surgery for Peritoneal Malignancy—Results of Phase 1 of the PRECINCT Study in 707 Patients

Author

Bhatt, Aditi, Villeneuve, Laurent, Sardi, Armando, Souadka, Amine, Buseck, Alison, Moran, Brendan J., El Khannousi, Basma, de Pedro, Carlos Gonzalez, Baratti, Dario, Biacchi, Danielle, Morris, David, Labow, Daniel, Levine, Edward A., Mohamed, Faheez, Adeleke, Gbadebo, Goswami, Gaurav, Bonnefoy, Isabelle, Cummins Perry, Katherine, Votanopoulos, Konstantinos I., Parikh, Loma, Deraco, Marcello, Alyami, Mohammad, Cohen, Noah, Benzerdjeb, Nazim, Shah, Nehal, El Bahaoui, Nezha, Khajoueinejad, Nazanin, Rousset, Pascal, Shen, Perry, Barat, Shoma, Stanford, Sophia, Khouchoua, Selma, Troob, Samantha, Shaikh, Sakina, Sarpel, Umut, Gushchin, Vadim, Samuel, Vasanth Mark, Kepenekian, Vahan, Sammartino, Paolo, and Glehen, Olivier

Published
2024
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7. Plasma Exosome Gene Signature Differentiates Colon Cancer from Healthy Controls.

Author

Vallejos, Paul A, Gonda, Amber, Yu, Jingjing, Sullivan, Brittany G, Ostowari, Arsha, Kwong, Mei Li, Choi, Audrey, Selleck, Matthew J, Kabagwira, Janviere, Fuller, Ryan N, Gironda, Daniel J, Levine, Edward A, Hughes, Christopher CW, Wall, Nathan R, Miller, Lance D, and Senthil, Maheswari

Subjects
Humans, Colonic Neoplasms, RNA, Bayes Theorem, Exosomes, Biomarkers, Tumor, Digestive Diseases, Colo-Rectal Cancer, Clinical Research, Cancer, Genetics, Biotechnology, Human Genome, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundLiquid biopsies have become an integral part of cancer management as minimally invasive options to detect molecular and genetic changes. However, current options show poor sensitivity in peritoneal carcinomatosis (PC). Novel exosome-based liquid biopsies may provide critical information on these challenging tumors. In this initial feasibility analysis, we identified an exosome gene signature of 445 genes (ExoSig445) from colon cancer patients, including those with PC, that is distinct from healthy controls.MethodsPlasma exosomes from 42 patients with metastatic and non-metastatic colon cancer and 10 healthy controls were isolated and verified. RNAseq analysis of exosomal RNA was performed and differentially expressed genes (DEGs) were identified by the DESeq2 algorithm. The ability of RNA transcripts to discriminate control and cancer cases was assessed by principal component analysis (PCA) and Bayesian compound covariate predictor classification. An exosomal gene signature was compared with tumor expression profiles of The Cancer Genome Atlas.ResultsUnsupervised PCA using exosomal genes with greatest expression variance showed stark separation between controls and patient samples. Using separate training and test sets, gene classifiers were constructed capable of discriminating control and patient samples with 100% accuracy. Using a stringent statistical threshold, 445 DEGs fully delineated control from cancer samples. Furthermore, 58 of these exosomal DEGs were found to be overexpressed in colon tumors.ConclusionsPlasma exosomal RNAs can robustly discriminate colon cancer patients, including patients with PC, from healthy controls. ExoSig445 can potentially be developed as a highly sensitive liquid biopsy test in colon cancer.

Published
2023

13. ASO Visual Abstract: Detection of Residual Peritoneal Metastases Following Cytoreductive Surgery Using Pegsitacianine, a pH-Sensitive Imaging Agent—Final Results from a Phase 2 Study

Author

Wagner, Patrick, Levine, Edward A., Kim, Alex C., Shen, Perry, Fleming, Nicole D., Westin, Shannon N., Berry, Laurel K., Karakousis, Giorgos C., Tanyi, Janos L., Olson, Madeline T., Madajewski, Brian, Ostrander, Brian, Krishnan, Kartik, Balch, Charles M., and Bartlett, David L.

Published
2024
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23. Survival Outcomes of Optimally Treated Colorectal Metastases: The Importance of R0 Status in Surgical Treatment of Hepatic and Peritoneal Surface Disease

Author

Solsky, Ian, Moaven, Omeed, Valenzuela, Cristian D., Lundy, Megan, Stauffer, John A., Del Piccolo, Nico R., Cheung, Tanto, Corvera, Carlos U., Wisneski, Andrew D., Cha, Charles, Zarandi, Nima Pourhabibi, Dourado, Justin, Russell, Gregory, Levine, Edward A., Votanopoulos, Konstantinos I., and Shen, Perry

Published
2023
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28. Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer

Author

Sevelda, Paul, Haslbauer, Ferdinand, Penzinger, Monika, Öhler, Leopold, Tinchon, Christoph, Greil, Richard, Heibl, Sonja, Bartsch, Rupert, Wette, Viktor, Singer, Christian F., Pasterk, Claudia, Helfgott, Ruth, Pristauz-Telsnigg, Gunda, Stöger, Herbert, Weltermann, Angsar, Egle, Daniel, Thiel, Irene, Fuchs, David, Rumpold, Holger, Strasser-Weippl, Kathrin, Rautenberg, Beate, Müller, Volkmar, Schmidt, Marcus, Paepke, Stefan, Aydogdu, Mustafa, Thomssen, Christoph, Rom, Joachim, Mau, Christine, Fasching, Peter, Göhring, Uwe-Jochen, Kühn, Thorsten, Noeding, Stefanie, Kümmel, Sherko, Hackmann, John, Stickeler, Elmar, Joshi, Abhishek, Dewar, Joanna, Friedlander, Michael, Phillips, Kelly-Anne, Antill, Yoland, Woodward, Natasha, Abdi, Ehtesham, Tiley, Susan, George, Mathew, Boadle, David, Goodwin, Annabel, van der Westhuizen, Andre, Kannourakis, George, Murray, Nicholas, McCarthy, Nicole, Kroep, Judith, de Boer, Maaike, Heijns, Joan, Jager, Agnes, Erdkamp, Franciscus, Bakker, Sandra, Sonke, Gabe S., Sami, Amer, Mackey, John, Prady, Catherine, Eisen, Andrea, Desbiens, Christine, Patocskai, Erica, Ferrario, Cristiano, Gelmon, Karen, Bordeleau, Louise, Chalchal, Haji, Niraula, Saroj, ido wolf, Senkus, Elżbieta, Duhoux, François, Randal d’Hondt, Luce, Sylvie, Roodenbeke, Daphné t’Kint de, Papadimitriou, Konstantinos, Borms, Marleen, Quaghebeur, Claire, Jacot, William, Brain, Etienne, Venat-Bouvet, Laurence, Lortholary, Alain, Nowecki, Zbigniew, Cardoso, Fátima, Hayward, Richard, Bella, Santiago, Lazzaro, Mauricio Fernández, Pilnik, Norma, Fein, Luis E., Blajman, Cesar, Lerzo, Guillermo, Varela, Mirta, Zarba, Juan Jose, Kaen, Diego, Constanzo, Maria Victoria, Tio, Joke, Siggelkow, Wulf, Jackisch, Christian, Grischke, Eva Maria, Zahm, Dirk, Tato-Varela, Sara, Schmatloch, Sabine, Klare, Peter, Stefek, Andrea, Rhiem, Kerstin, Hoffmann, Oliver, Deryal, Mustafa, Gröll, Isolde, Ledwon, Peter, Uleer, Christoph, Krabisch, Petra, Potenberg, Jochem, Darsow, Maren, Park-Simon, Tjoung-Won, Höffkes, Heinz-Gert, Emde, Till-Oliver, Graffunder, Gerd, Tomé, Oliver, Forstmeyer, Dirk, Terhaag, Jürgen, Salat, Christoph, Kast, Karin, Weniger, Steffi, Schreiber, Carsten, Heinrich, Bernhard, Dieterich, Max, Wüllner, Michaela Penelope, Conejero, Raquel Andrés, García Sáenz, José Ángel, Martinez, Lourdes Calvo, Lanza, Angels Arcusa, Murillo, Serafín Morales, Carrasco, Fernando Henao, Tormo, Salvador Blanch, López, Isabel Álvarez, Delgado Mingorance, Juan Ignacio, Gomez, Elena Álvarez, Santisteban, Marta, Jurado, Josefina Cruz, Quiroga, Vanesa, Borrego, Manuel Ruiz, Martínez de Dueñas, Eduardo, Alés Martínez, Jose Enrique, De la Haba, Juan, Jañez, Noelia Martínez, Lescure, Álvaro Rodríguez, Torres, Antonio Antón, Crusades, Gema Llort, González-Santiago, Santiago, Aragones, Antonia Marquez, Ortega, Ana Laura, Molins, Agusti Barnadas, Chacón López-Muñiz, José Ignacio, Jiménez, Miguel Martín, Bertrán, Ana Santaballa, Rodríguez, César, Cortijo, Lucía González, Cretella, Elisabetta, Cortesi, Laura, Ruggeri, Enzo Maria, Verusio, Claudio, Gori, Stefania, Bonetti, Andrea, Mosconi, Anna Maria, Johannsson, Oskar, Jerusalem, Guy, Neven, Patrick, Nagy, Tünde, Pinotti, Graziella, Colleoni, Marco A., Bernardo, Antonio, Gianni, Lorenzo, Bucci, Eraldo, Biganzoli, Laura, Dedes, Konstantin, Novak, Urban, Zaman, Khalil, Braybrooke, Jeremy, Winter, Matthew, Rea, Daniel, Kelleher, Muireann, Barrett, Sophie, Chan, Stephen, Hickish, Tamas, Hurwitz, Jane, Conibear, John, Jegannathen, Apurna, Parton, Marina, Tutt, Andrew, Allerton, Rozenn, Borley, Annabel, Armstrong, Anne, Copson, Ellen, Levitt, Nicola, Abraham, Jean, Perren, Timothy, Roylance, Rebecca, Ishida, Kazushige, Toyama, Tatsuya, Masuda, Norikazu, Watanabe, Junichiro, Tokunaga, Eriko, Kinoshita, Takayuki, Rai, Yoshiaki, Takada, Masahiro, Yanagita, Yasuhiro, Nakamura, Rikiya, Nakayama, Takahiro, Naoi, Yasuto, Iwata, Hiroji, Nakamura, Seigo, Takahashi, Masato, Aogi, Kenjiro, Tsugawa, Koichiro, Mukai, Hirofumi, Takano, Toshimi, Osaki, Akihiko, Sato, Nobuaki, Yamauchi, Hideko, Tokuda, Yutaka, Ito, Mitsuya, Sugimoto, Takeki, Bahadur, Shakeela W., Ganz, Patricia A., Lu, Min J., Mita, Monica M., Waisman, James, Polikoff, Jonathan A., Telli, Melinda L., Seaward, Samantha A., Suga, J. Marie, Durna, Lara N., Carney, Jennifer Fu, Menter, Alex, Puthillath, Ajithkumar, Rohatgi, Nitin, Feusner, James H., Bobolis, Kristie A., Eisenberg, Peter D., Wong, Derrick, Borges, Virginia F., Urquhart, Alexander T., Hofstatter, Erin W., McCarron, Edward C., Isaacs, Claudine, Herbolsheimer, Pia, Varadarajan, Ramya, Raben, Adam, Deveras, Ruby Anne E., Valdes-Albini, Frances, Mahtani, Reshma L., Meisel, Jane L., Sumrall, Bradley T., Jones, Cheryl F., Ofori, Samuel N., Sumida, Kenneth N.M., Karwal, Mark, Wilbur, Deborah W., Singh, (Joe), Spector, David M., Schallenkamp, John, Merkel, Douglas E., Lo, Shelly S., Khosla, Pam G., Cristofanilli, Massimo, Flaum, Lisa, Hoskins, Kent F., Cobleigh, Melody A., Lambiase, Elyse A., Hahn, Olwen M., Oliff, Ira A., Faller, Bryan A., Wade, James L., Burhani, Nafisa D., Gil, Amaryllis, Einhorn, Harvey E., Storniolo, Anna M.V., Chang, Brian K., Kalra, Maitri, Robin, Erwin L., Ansari, Bilal, Sharma, Priyanka, Dakhil, Shaker R., Deming, Richard L., Cole, John T., Hanson, David S., Ochoa, Augusto C., Garber, Judy E., Zimbler, Harvey, Armstrong, Deborah K., Tkaczuk, Katherine H.R., Riseberg, David A., O'Connor, Brian M., Openshaw, Thomas H., Zakalik, Dana, Vakhariya, Cynthia M., Schott, Anne F., Simon, Michael S., Doyle, Thomas J., Al Baghdadi, Tareq, VanderWoude, Amy, Flynn, Patrick J., Zera, Richard T., Friday, Bret E.B., Ruddy, Kathryn J., Smith, Ron, Ademuyiwa, Olabisi, Foluso, Ellis, Robert, Carlson, Jay W., Marchello, T, Benjamin, Levine, Edward A., Marcom, Paul K., Harkness, Cameron B., Tan, Antoinette R., Charles, William J., Kuzma, Charles S., Asaad, Shonda, Radford, James E., Steen, Preston D., Unnikrishnan, Madhu, Seeger, Grant R., Leu, Kirsten M.H., Copur, Mehmet S., Hauke, Ralph J., Soori, Gamini S., Arrick, Bradley A., Reeder, Jennifer G., Toppmeyer, Deborah L., Dayao, Zoneddy R., Adams, Sylvia, Andreopoulou, Eleni, Allison, Magnuson, Anampa Mesias, Jesus D., Sharma, Ruby, Ramaswamy, Bhuvaneswari, Gerds, Aaron T., Shenk, Robert R., Gross, Howard M., Trehan, Shruti, Razaq, Wajeeha, Mansoor, Abdul H., Hilton, Christie J., Brufsky, Adam M., Huynh, Chanh, Chowdhury, Nabila, Domchek, Susan M., Sigurdson, Elin R., Cescon, Terrence P., Rovito, Marc A., DeNittis, Albert S., Vogel, Victor G., Julian, Thomas B., Boyle, L.E., Baez-Diaz, Luis, Brescia, Frank J., Doster, John E., Siegel, Robert D., Wong, Lucas, Patel, Tejal, Nangia, Julie R., Jones, Catherine A., Cannon, George M., Bear, Harry D., Vachhani, Hetal, Wilkinson, Mary, Wood, Marie E., Yan, Fengting, Sui, Xingwei, van Haelst, Carol M., Specht, Jennifer M., Zhuo, Ying, Qamar, Rubina, Ryan, Matthew L., Stockham, Abigail, Virani, Shamsuddin, Gayle, Arlene A., Jubelirer, Steven J., Kurian, Sobha, Salkeni, Mohamad A., Loman, Niklas, Linderholm, Barbro, Silander, Gustav, Hallbeck, Anna-Lotta, von Wachenfeldt Väppling, Anna, Curtit, Elsa, Cardoso, Catarina, Braga, Sofia, Abreu, Miguel, Casa-Nova, Mafalda, Nave, Mónica, Ciruelos Gil, Eva María, Gelpi, Judith Balmaña, Ortega, Adela Fernández, Padró, Josep Gumà, Bermejo de las Heras, Begoña, Cao, María González, Bañuelos, Juan Cueva, Company, Jesús Alarcon, Villaró, Gemma Viñas, Estevez, Laura García, Huober, Jens, Busch, Steffi, Fehm, Tanja, Hahn, Antje, Grafe, Andrea, Noesselt, Thomas, Dewitz, Thomas, Wagner, Harald, Bechtner, Christina, Weigel, Michael, Kolberg, Hans-Christian, Decker, Thomas, Thomalla, Jörg, Hesse, Tobias, Harbeck, Nadia, Jens-Uwe Blohmer, Jan Schröder, Wolf Sütterlin, Marc, Altena, Renske, Chiu, Chang-Fang, Chen, Shin-Cheh, Hou, Ming-Feng, Chang, Yuan-Ching, Chen, Shang-Hung, Chen, Shou-Tung, Huang, Chiun-Sheng, Yeh, Dah-Cherng, Yu, Jyh-Cherng, Tseng, Ling-Ming, Chung, Wei-Pang, Mailliez, Audrey, Petit, Thierry, Delaloge, Suzette, Lévy, Christelle, Dalivoust, Philippe, Extra, Jean-Marc, Mouret-Reynier, Marie-Ange, Hardy-Bessard, Anne-Claire, Simon, Hélène, L'Haridon, Tiffenn, Mege, Alice, Giacchetti, Sylvie, Chakiba-Brugere, Camille, Gratet, Alain, Pottier, Virginie, Ferrero, Jean-Marc, Tennevet, Isabelle, Perrin, Christophe, Canon, Jean-Luc, Joris, Sofie, Shao, Zhimin, Xu, Binghe, Jiang, ZeFei, Sun, Qiang, Shen, Kunwei, Pang, Da, Zhang, Jin, Wang, Shui, Yang, Hongjian, Liao, Ning, Zheng, Hong, Fu, Peifen, Song, Chuangui, Wang, Yongsheng, Fan, Zhimin, Geng, Cuizhi, Tredan, Olivier, Landherr, László, Kaufman, Bella, Yerushalmi, Rinat, Uziely, Beatrice, Conte, Pierfranco, Zamagni, Claudio, Bianchini, Giampaolo, De Laurentiis, Michelino, Tondini, Carlo, Gebbia, Vittorio, Ciccarese, Mariangela, Sarosiek, Tomasz, Mackiewicz, Jacek, Słowińska, Anna, Kalinka, Ewa, Huzarski, Tomasz, Im, Seock-Ah, Jung, Kyung Hae, Sohn, Joo Hyuk, Kim, Jee Hyun, Lee, Keun Seok, Park, Yeon Hee, Lee, Kyoung Eun, Chae, Yee Soo, Cho, Eun Kyung, Geyer, C.E., Jr., Garber, J.E., Gelber, R.D., Yothers, G., Taboada, M., Ross, L., Rastogi, P., Cui, K., Arahmani, A., Aktan, G., Armstrong, A.C., Arnedos, M., Balmaña, J., Bergh, J., Bliss, J., Delaloge, S., Domchek, S.M., Eisen, A., Elsafy, F., Fein, L.E., Fielding, A., Ford, J.M., Friedman, S., Gelmon, K.A., Gianni, L., Gnant, M., Hollingsworth, S.J., Im, S.-A., Jager, A., Jóhannsson, Ó. Þ, Lakhani, S.R., Janni, W., Linderholm, B., Liu, T.-W., Loman, N., Korde, L., Loibl, S., Lucas, P.C., Marmé, F., Martinez de Dueñas, E., McConnell, R., Phillips, K.-A., Piccart, M., Rossi, G., Schmutzler, R., Senkus, E., Shao, Z., Sharma, P., Singer, C.F., Španić, T., Stickeler, E., Toi, M., Traina, T.A., Viale, G., Zoppoli, G., Park, Y.H., Yerushalmi, R., Yang, H., Pang, D., Jung, K.H., Mailliez, A., Fan, Z., Tennevet, I., Zhang, J., Nagy, T., Sonke, G.S., Sun, Q., Parton, M., Colleoni, M.A., Schmidt, M., Brufsky, A.M., Razaq, W., Kaufman, B., Cameron, D., Campbell, C., and Tutt, A.N.J.

Published
2022
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35. ASO Visual Abstract: Survival Outcomes of Optimally Treated Colorectal Metastases–The Importance of R0 Status in Surgical Treatment of Hepatic and Peritoneal Surface Disease

Author

Solsky, Ian, Moaven, Omeed, Valenzuela, Cristian D., Lundy, Megan, Stauffer, John A., Del Piccolo, Nico R., Cheung, Tanto, Corvera, Carlos U., Wisneski, Andrew D., Cha, Charles, Zarandi, Nima Pourhabibi, Dourado, Justin, Russell, Gregory, Levine, Edward A., Votanopoulos, Konstantinos I., and Shen, Perry

Published
2023
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38. Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Metastases From a Small Bowel Adenocarcinoma: Multi-Institutional Experience

Author

Liu, Yang, Yonemura, Yutaka, Levine, Edward A, Glehen, Olivier, Goere, Diane, Elias, Dominique, Morris, David L, Sugarbaker, Paul H, Tuech, Jean J, Cashin, Peter, Spiliotis, John D, de Hingh, Ignace, Ceelen, Wim, Baumgartner, Joel M, Piso, Pompiliu, Katayama, Kanji, Deraco, Marcello, Kusamura, Shigeki, Pocard, Marc, Quenet, François, Fushita, Sachio, and The BIG-RENAPE Group

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Clinical Research, Cancer, 6.4 Surgery, Evaluation of treatments and therapeutic interventions, Adenocarcinoma, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Cytoreduction Surgical Procedures, Disease-Free Survival, Female, Humans, Hyperthermia, Induced, Intestinal Neoplasms, Intestine, Small, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Grading, Peritoneal Neoplasms, Postoperative Complications, Registries, Severity of Illness Index, Survival Rate, BIG-RENAPE Group, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundThe multi-institutional registry in this study evaluated the outcome after cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with peritoneal metastases (PM) from small bowel adenocarcinoma (SBA).MethodsA multi-institutional data registry including 152 patients with PM from SBA was established. The primary end point was overall survival (OS) after CRS plus HIPEC.ResultsBetween 1989 and 2016, 152 patients from 21 institutions received a treatment of CRS plus HIPEC. The median follow-up period was 20 months (range 1-100 months). Of the 152 patients, 70 (46.1%) were women with a median age of 54 years. The median peritoneal cancer index (PCI) was 10 (mean 12; range 1-33). Completeness of cytoreduction (CCR) 0 or 1 was achieved for 134 patients (88.2%). After CRS and HIPEC, the median OS was 32 months (range 1-100 months), with survival rates of 83.2% at 1 year, 46.4% at 3 years, and 30.8% at 5 years. The median disease-free survival after CCR 0/1 was 14 months (range 1-100 months). The treatment-related mortality rate was 2%, and 29 patients (19.1%) experienced grades 3 or 4 operative complications. The period between detection of PM and CRS plus HIPEC was 6 months or less (P = 0.008), and multivariate analysis identified absence of lymph node metastasis (P = 0.037), well-differentiated tumor (P = 0.028), and PCI of 15 or lower (P = 0.003) as independently associated with improved OS.ConclusionThe combined treatment strategy of CRS plus HIPEC achieved prolonged survival for selected patients who had PM from SBA with acceptable morbidity and mortality.

Published
2018

40. Phase I trial of talimogene laherparepvec for the treatment of peritoneal surface malignancies (TEMPO).

Author

Stewart, John H., primary, Lowe, Melissa, additional, Chapple, Andrew G, additional, Niedzwiecki, Donna, additional, Moyer, Ashley, additional, Bolch, Emily, additional, MacLaughlan, Shannon Diane, additional, Levine, Edward A., additional, Moaven, Omeed, additional, Nettu, Niharika, additional, Strickler, John H, additional, and Blazer, Dan G., additional

Published
2024
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41. Development of a Prognostic Nomogram and Nomogram Software Application Tool to Predict Overall Survival and Disease-Free Survival After Curative-Intent Gastrectomy for Gastric Cancer

Author

Spolverato, Gaya, Capelli, Giulia, Lorenzoni, Giulia, Gregori, Dario, Squires, Malcolm H., Poultsides, George A., Fields, Ryan C., Bloomston, Mark P., Weber, Sharon M., Votanopoulos, Konstantinos I., Acher, Alexandra W., Jin, Linda X., Hawkins, William G., Schmidt, Carl R., Kooby, David A., Worhunsky, David J., Saunders, Neil D., Levine, Edward A., Cho, Clifford S., Maithel, Shishir K., Pucciarelli, Salvatore, and Pawlik, Timothy M.

Published
2022
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43. Regarding: Predicting Regional Lymph Node Recurrence in The Modern Age of Tumor-Positive Sentinel Node Melanoma

Author

Thompson, John F., Hyngstrom, John, Caracò, Corrado, Zager, Jonathan S., Jahkola, Tiina, Bowles, Tawnya L., Pennacchioli, Elisabetta, Hoekstra, Harald J., Moncrieff, Marc, Ingvar, Christian, van Akkooi, Alexander, Sabel, Michael S., Levine, Edward A., Henderson, Michael, Dummer, Reinhard, Rossi, Carlo Riccardo, Kane, 3rd, John M., Trocha, Steven, Wright, Frances, Byrd, David R., Matter, Maurice, MacKenzie-Ross, Alastair, Kelley, Mark C., Terheyden, Patrick, Huston, Tara L., Wayne, Jeffrey D., Neuman, Heather, Smithers, B. Mark, Desai, Darius, Gershenwald, Jeffrey E., Schneebaum, Shlomo, Gesierich, Anja, Jacobs, Lisa K., Lewis, James M., O’Donoghue, Cristina, Sardi, Armando, McKinnon, J. Greg, Slingluff, Craig L., Farma, Jeffrey M., Schultz, Erwin, Scheri, Randall P., Vidal-Sicart, Sergi, Testori, Alessandro A. E., Scolyer, Richard A., Elashoff, David E., Cochran, Alistair J., and Faries, Mark B.

Published
2023
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46. A Novel T-Stage Classification System for Adrenocortical Carcinoma: Proposal from the US Adrenocortical Carcinoma Study Group

Author

Poorman, Caroline E, Ethun, Cecilia G, Postlewait, Lauren M, Tran, Thuy B, Prescott, Jason D, Pawlik, Timothy M, Wang, Tracy S, Glenn, Jason, Hatzaras, Ioannis, Shenoy, Rivfka, Phay, John E, Keplinger, Kara, Fields, Ryan C, Jin, Linda X, Weber, Sharon M, Salem, Ahmed, Sicklick, Jason K, Gad, Shady, Yopp, Adam C, Mansour, John C, Duh, Quan-Yang, Seiser, Natalie, Solórzano, Carmen C, Kiernan, Colleen M, Votanopoulos, Konstantinos I, Levine, Edward A, Staley, Charles A, Poultsides, George A, and Maithel, Shishir K

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Adrenal Cortex Neoplasms, Adrenalectomy, Adrenocortical Carcinoma, Female, Follow-Up Studies, Humans, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Invasiveness, Neoplasm Staging, Retrospective Studies, Risk Factors, Survival Rate, Treatment Outcome, Tumor Burden, United States, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BACKGROUND:The 7th AJCC T-stage system for adrenocortical carcinoma (ACC), based on size and extra-adrenal invasion, does not adequately stratify patients by survival. Lymphovascular invasion (LVI) is a known poor prognostic factor. We propose a novel T-stage system that incorporates LVI to better risk-stratify patients undergoing resection for ACC. METHOD:Patients undergoing curative-intent resections for ACC from 1993 to 2014 at 13 institutions comprising the US ACC Group were included. Primary outcome was disease-specific survival (DSS). RESULTS:Of the 265 patients with ACC, 149 were included for analysis. The current T-stage system failed to differentiate patients with T2 versus T3 disease (p = 0.10). Presence of LVI was associated with worse DSS versus no LVI (36 mo vs. 168 mo; p = 0.001). After accounting for the individual components of the current T-stage system (size, extra-adrenal invasion), LVI remained a poor prognostic factor on multivariable analysis (hazard ratio 2.14, 95% confidence interval 1.05-4.38, p = 0.04). LVI positivity further stratified patients with T2 and T3 disease (T2: 37 mo vs. median not reached; T3: 36 mo vs. 96 mo; p = 0.03) but did not influence survival in patients with T1 or T4 disease. By incorporating LVI, a new T-stage classification system was created: [T1: ≤ 5 cm, (-)local invasion, (+/-)LVI; T2: > 5 cm, (-)local invasion, (-)LVI OR any size, (+)local invasion, (-)LVI; T3: > 5 cm, (-)local invasion, (+)LVI OR any size, (+)local invasion, (+)LVI; T4: any size, (+)adjacent organ invasion, (+/-)LVI]. Each progressive new T-stage group was associated with worse median DSS (T1: 167 mo; T2: 96 mo; T3: 37 mo; T4: 15 mo; p

Published
2018

47. Blood Transfusion and Survival for Resected Adrenocortical Carcinoma: A Study from the United States Adrenocortical Carcinoma Group

Author

Poorman, Caroline E, Postlewait, Lauren M, Ethun, Cecilia G, Tran, Thuy B, Prescott, Jason D, Pawlik, Timothy M, Wang, Tracy S, Glenn, Jason, Hatzaras, Ioannis, Shenoy, Rivfka, Phay, John E, Keplinger, Kara, Fields, Ryan C, Jin, Linda X, Weber, Sharon M, Salem, Ahmed, Sicklick, Jason K, Gad, Shady, Yopp, Adam C, Mansour, John C, Duh, Quan-Yang, Seiser, Natalie, Solorzano, Carmen C, Kiernan, Colleen M, Votanopoulos, Konstantinos I, Levine, Edward A, Staley, Charles A, Poultsides, George A, and Maithel, Shishir K

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Clinical Trials and Supportive Activities, Basic Behavioral and Social Science, Digestive Diseases, Cancer, Rare Diseases, Clinical Research, Behavioral and Social Science, 6.4 Surgery, Evaluation of treatments and therapeutic interventions, Adrenal Cortex Neoplasms, Adrenocortical Carcinoma, Blood Transfusion, Female, Humans, Male, Middle Aged, Prognosis, Proportional Hazards Models, Retrospective Studies, Survival Rate, United States, Surgery, Clinical sciences
Abstract

Perioperative blood transfusion is associated with decreased survival in pancreatic, gastric, and liver cancer. The effect of transfusion in adrenocortical carcinoma (ACC) has not been studied. Patients with available transfusion data undergoing curative-intent resection of ACC from 1993 to 2014 at 13 institutions comprising the United States Adrenocortical Carcinoma Group were included. Factors associated with blood transfusion were determined. Primary and secondary end points were recurrence-free survival (RFS) and overall survival (OS), respectively. Out of 265 patients, 149 were included for analysis. Out of these, 57 patients (38.3%) received perioperative transfusions. Compared to nontransfused patients, transfused patients more commonly had stage 4 disease (46% vs 24%, P = 0.01), larger tumors (15.8 vs 10.2 cm, P < 0.001), inferior vena cava involvement (24.6% vs 5.4%, P = 0.002), additional organ resection (78.9% vs 36.3%, P < 0.001), and major complications (29% vs 2%, P < 0.001). Transfusion was associated with decreased RFS (8.9 vs 24.7 months, P = 0.006) and OS (22.8 vs 91.0 months, P < 0.001). On univariate Cox regression, transfusion, stage IV, hormonal hypersecretion, and adjuvant therapy were associated with decreased RFS. On multivariable analysis, only transfusion [hazard ratio (HR) = 1.7, 95% confidence interval (CI) =1.0-2.9, P = 0.04], stage IV (HR = 3.2, 95% CI = 1.7-5.9, P < 0.001), and hormonal hypersecretion (HR = 2.6, 95% CI = 1.5-4.2, P < 0.001) were associated with worse RFS. When applying this model to OS, similar associations were seen (transfusion HR = 2.0, 95% CI = 1.1-3.8, P = 0.02; stage 4 HR = 6.2, 95% CI = 3.1-12.4, P < 0.001; hormonal hypersecretion HR = 3.5, 95% CI = 1.9-6.4, P < 0.001). There was no difference in outcomes between patients who received 1 to 2 units versus >2 units of packed red blood cells in median RFS (8.9 vs 8.4 months, P = 0.95) or OS (26.5 vs 18.6 months, P = 0.63). Perioperative transfusion is associated with earlier recurrence and decreased survival after curative-intent resection of ACC. Strategies and protocols to minimize blood transfusion should be developed and followed.

Published
2017

48. Cumulative GRAS Score as a Predictor of Survival After Resection for Adrenocortical Carcinoma: Analysis From the U.S. Adrenocortical Carcinoma Database

Author

Baechle, Jordan J., Marincola Smith, Paula, Solórzano, Carmen C., Tran, Thuy B., Postlewait, Lauren M., Maithel, Shishir K., Prescott, Jason, Pawlik, Timothy, Wang, Tracy S., Glenn, Jason, Hatzaras, Ioannis, Shenoy, Rivfka, Phay, John E., Shirley, Lawrence A., Fields, Ryan C., Jin, Linda, Abbott, Daniel E., Ronnekleiv-Kelly, Sean, Sicklick, Jason K., Yopp, Adam, Mansour, John, Duh, Quan-Yang, Seiser, Natalie, Votanopoulos, Konstantinos, Levine, Edward A., Poultsides, George, and Kiernan, Colleen M.

Published
2021
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49. Impact of Cavity Shave Margins on Margin Status in Patients with Pure Ductal Carcinoma In Situ

Author

Howard-McNatt, Marissa, Dupont, Elisabeth, Tsangaris, Theodore, Garcia-Cantu, Carlos, Chiba, Akiko, Berger, Adam C., Levine, Edward A., Gass, Jennifer S., Ollila, David W., Gallagher, Kristalyn, Lum, Sharon S., Martinez, Ricardo D., Willis, Alliric I., Pandya, Sonali V., Brown, Eric A., Fenton, Andrew, Mendiola, Amanda, Murray, Mary, Haddad, Victor, Solomon, Naveenraj L., Senthil, Maheswari, Bansil, Hannah, Snyder, Samuel K., Edmonson, David, Lazar, Melissa, Namm, Jukes P., Li, Fangyong, Butler, Meghan, McGowan, Noreen E., Herrera, Maria E., Avitan, Yoana P., Yoder, Brian, McPartland, Tara, and Chagpar, Anees B.

Published
2021
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