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785 results on '"Levin, Leonard A."'

3. Ophthalmic and Systemic Factors of Acute Nonarteritic Anterior Ischemic Optic Neuropathy in the Quark207 Treatment Trial

Author

Clare, Fraser, Celia, Chen, Neil, Shuey, Stephen, Colley, Wang, Ningli, Dou, Hongliang, Zhong, Yong, Tang, Luosheng, Han, Quanhong, Dirk, Sandner, Maria-Andreea, Gamulescu, Nicole, Eter, Helmut, Wilhelm, Katrin, Lorenz, Santhosh, Krishna G., Ramesh, Kekunnaya, S, Ambika, Kumudini, Sharma, Warkad, Vivekanand Uttamrao, Rohit, Saxena, Mahesh, Kumar S., Dipankar, Das, Atul, Hegade, Shahana, Mazumdar, Sachin, Daighavane, Virender, Sachdeva, Hadas, Kalish, Ainat, Klein, Ruth, Huna-Baron, Hana, Leiba, Nitza, Goldenberg-Cohen, Marina, Shneck, Joshua, Kruger, Pasquale, Ciardella Antonio, Gianni, Virgili, Arturo, Carta, Stefania, Bianchi Marzoli, Tow, Sharon, Fang, Chin Chee, Peter, MacIntosh, Jeffrey, Bennett, Byron, Lam, Bradley, Katz, Zoe, Williams, Michael, Lee, Madhura, Tamhankar, Rudrani, Banik, Michael, Rauser, Marc, Levy, Joyce, Liao Yaping, James, Luu, Michael, Tibbetts, David, Scales, Robert, Lesser, Anil, Patel, Syndee, Givre, Gregory, Van Stavern, Steven, Hamilton, Vivian, Rismondo, Courtney, Francis, Dean, Cestari, Marc, Dinkin, John, Pula, Padmaja, Sudhakar, Steven, Newman, Rosa, Tang, Joseph, Chacko, Sachin, Kedar, Peter, Quiros, Larry, Frohman, Nicholas, Volpe, Patrick, Sibony, John, Chen, Luis, Mejico, Gregory, Kosmorsky, Virgil, Alfaro Daniel, David, Katz, Andrew, Lee, Lindsey, DeLott, Vivek, Patel, Swaraj, Bose, Crandall, Peeler, Bhatti, Tariq, Kupersmith, Mark J., Fraser, Clare L., Morgenstern, Rachelle, Miller, Neil R., Levin, Leonard A., and Jette, Nathalie

Published
2024
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5. Peripheral Nerve Sheath Tumors of the Orbit

Author

Carniciu, Anaïs, Kahana, Alon, Levin, Leonard A., Steele, Eric, Section editor, Ng, John, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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6. Hereditary Optic Neuropathies

Author

Karanjia, Rustum, Yu-Wai-Man, Patrick, Newman, Nancy J., Levin, Leonard, Section editor, Cestari, Dean, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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8. Central Eye Movement Disorders

Author

Weber, Konrad P., Halmágyi, G. Michael, Levin, Leonard, Section editor, Cestari, Dean, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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9. Myasthenia Gravis

Author

Keung, Bonnie M., Hamilton, Steven R., Levin, Leonard, Section editor, Cestari, Dean, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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10. The Pupils and Accommodation

Author

Kardon, Randy, Levin, Leonard, Section editor, Cestari, Dean, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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11. Nonorganic Visual Disorders

Author

Bose, Swaraj, Levin, Leonard, Section editor, Cestari, Dean, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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13. Diseases of the Extraocular Muscles

Author

Heidary, Gena, Borchert, Mark, Levin, Leonard, Section editor, Cestari, Dean, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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14. Headache and Eye Pain

Author

Digre, Kathleen B., Friedman, Deborah I., Levin, Leonard, Section editor, Cestari, Dean, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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15. Retrochiasmal Disorders

Author

Vuong, Laurel N., Hedges, Thomas R., III, Levin, Leonard, Section editor, Cestari, Dean, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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16. Tumors of the Anterior Visual Pathways

Author

Egan, Robert A., Levin, Leonard, Section editor, Cestari, Dean, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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17. Imaging in Neuro-ophthalmology

Author

Al Othman, Bayan, Kini, Ashwini, Costello, Fiona, Lee, Andrew, Levin, Leonard, Section editor, Cestari, Dean, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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18. Chiasmal Disorders

Author

Pless, Misha L., Levin, Leonard, Section editor, Cestari, Dean, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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19. Optic Neuritis

Author

Chen, John J., Lee, Michael S., Levin, Leonard, Section editor, Cestari, Dean, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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20. Optic Atrophy and Papilledema

Author

Karanjia, Rustum, Sadun, Alfredo A., Levin, Leonard, Section editor, Cestari, Dean, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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22. Ischemic Optic Neuropathy

Author

Pomeranz, Howard D., Levin, Leonard, Section editor, Cestari, Dean, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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23. Neuroophthalmologic Disease of the Retina

Author

Fortin, Elizabeth, Rizzo, Joseph F., III, Levin, Leonard, Section editor, Cestari, Dean, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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24. Examination of the Visual Field

Author

Barton, Jason J. S., Wirth, Magdalena A., Levin, Leonard, Section editor, Cestari, Dean, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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40. Ophthalmic and Systemic Factors of Acute Nonarteritic Anterior Ischemic Optic Neuropathy in the Quark207 Treatment Trial

Author

Kupersmith, Mark J., primary, Fraser, Clare L., additional, Morgenstern, Rachelle, additional, Miller, Neil R., additional, Levin, Leonard A., additional, Jette, Nathalie, additional, Clare, Fraser, additional, Celia, Chen, additional, Neil, Shuey, additional, Stephen, Colley, additional, Wang, Ningli, additional, Dou, Hongliang, additional, Zhong, Yong, additional, Tang, Luosheng, additional, Han, Quanhong, additional, Dirk, Sandner, additional, Maria-Andreea, Gamulescu, additional, Nicole, Eter, additional, Helmut, Wilhelm, additional, Katrin, Lorenz, additional, Santhosh, Krishna G., additional, Ramesh, Kekunnaya, additional, S, Ambika, additional, Kumudini, Sharma, additional, Warkad, Vivekanand Uttamrao, additional, Rohit, Saxena, additional, Mahesh, Kumar S., additional, Dipankar, Das, additional, Atul, Hegade, additional, Shahana, Mazumdar, additional, Sachin, Daighavane, additional, Virender, Sachdeva, additional, Hadas, Kalish, additional, Ainat, Klein, additional, Ruth, Huna-Baron, additional, Hana, Leiba, additional, Nitza, Goldenberg-Cohen, additional, Marina, Shneck, additional, Joshua, Kruger, additional, Pasquale, Ciardella Antonio, additional, Gianni, Virgili, additional, Arturo, Carta, additional, Stefania, Bianchi Marzoli, additional, Tow, Sharon, additional, Fang, Chin Chee, additional, Peter, MacIntosh, additional, Jeffrey, Bennett, additional, Byron, Lam, additional, Bradley, Katz, additional, Zoe, Williams, additional, Michael, Lee, additional, Madhura, Tamhankar, additional, Rudrani, Banik, additional, Michael, Rauser, additional, Marc, Levy, additional, Joyce, Liao Yaping, additional, James, Luu, additional, Michael, Tibbetts, additional, David, Scales, additional, Robert, Lesser, additional, Anil, Patel, additional, Syndee, Givre, additional, Gregory, Van Stavern, additional, Steven, Hamilton, additional, Vivian, Rismondo, additional, Courtney, Francis, additional, Dean, Cestari, additional, Marc, Dinkin, additional, John, Pula, additional, Padmaja, Sudhakar, additional, Steven, Newman, additional, Rosa, Tang, additional, Joseph, Chacko, additional, Sachin, Kedar, additional, Peter, Quiros, additional, Larry, Frohman, additional, Nicholas, Volpe, additional, Patrick, Sibony, additional, John, Chen, additional, Luis, Mejico, additional, Gregory, Kosmorsky, additional, Virgil, Alfaro Daniel, additional, David, Katz, additional, Andrew, Lee, additional, Lindsey, DeLott, additional, Vivek, Patel, additional, Swaraj, Bose, additional, Crandall, Peeler, additional, and Bhatti, Tariq, additional

Published
2024
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41. Neuroprotection for glaucoma: Requirements for clinical translation

Author

Levin, Leonard A, Crowe, Megan E, Quigley, Harry A, Participants, The Lasker IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration, Cordeiro, M Francesca, Donoso, Larry A, Liao, Y Joyce, Libby, Richard T, Masland, Richard H, Nickells, Robert W, Sieving, Paul A, and Sommer, Alfred

Subjects
Neurosciences, Eye Disease and Disorders of Vision, Neurodegenerative, Aging, Bioengineering, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Eye, Animals, Astrocytes, Axons, Glaucoma, Humans, Neuroprotection, Neuroprotective Agents, Optic Nerve Diseases, Retinal Ganglion Cells, Translational Research, Biomedical, Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants, Retinal ganglion cells, Medical Biochemistry and Metabolomics, Opthalmology and Optometry, Ophthalmology & Optometry
Abstract

Within the field of glaucoma research, neuroprotection is defined as slowing the functional loss in glaucoma by a mechanism independent of lowering of intraocular pressure. There is currently a great potential for research surrounding neuroprotection as it relates to glaucoma. Anatomical targets for neuroprotection should focus on upstream rather than downstream factors, and could include any part of the retinal ganglion cell, the glia, especially astrocytes or Muller cells, and vasculature. The great number of anatomical targets is exceeded only by the number of possible biochemical pathways and potential treatments. Successful treatment may be accomplished through the targeting of one or even a combination of multiple pathways. Once a treatment is shown effective in vitro, it should be evaluated in vivo with carefully chosen animal models and studied in sufficient numbers to detect statistically and clinically significant effects. Such a drug should have few systemic side effects and its delivery should be optimized so as to encourage compliance. There are still a multitude of possible screens available to test the efficacy of a neuroprotective drug and a single gold standard is ideal for the accurate assessment and comparison of new drugs. Future studies in neuroprotection should investigate the genetic component of the disease, novel pharmaceutical agents for new or known pathways, modulations of scleral biomechanics, and relation to research of other complex disorders of the central nervous system.

Published
2017

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