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2. Glioma Cells Expressing High Levels of ALDH5A1 Exhibit Enhanced Migration Transcriptional Signature in Patient Tumors

Author

Piperi, Christina, Saurty-Seerunghen, Mirca S., Levidou, Georgia, Sepsa, Athanasia, Trigka, Eleni-Andriana, Klonou, Alexia, Markouli, Mariam, Strepkos, Dimitrios, Spyropoulou, Anastasia, Kanakoglou, Dimitrios S., Lakiotaki, Eleftheria, Karatrasoglou, Eleni A., Boviatsis, Efstathios, El-Habr, Elias A., and Korkolopoulou, Penelope

Published
2023
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3. Application of the 5th WHO Guidelines for the Diagnosis of Lung Carcinoma in Small Lung Biopsies in a Tertiary Care Center: Is Insecurity of Pathologists for the Accurate Diagnosis Justified?

Author

Beckert, Manuela, Meyer, Christian, Papadopoulos, Thomas, and Levidou, Georgia

Subjects
SQUAMOUS cell carcinoma, LUNGS, PATHOLOGISTS, TERTIARY care, PROGRAMMED death-ligand 1
Abstract

Background/Objectives: The diagnosis of lung carcinoma (LC) is currently performed in small biopsies and according to the WHO classification by using limited stains to spare tissue for molecular testing. This procedure, however, often causes diagnostic uncertainty among pathologists. Methods: In this retrospective analysis, we compared the diagnosis made by these guidelines in 288 lung biopsies with that using more stains, as retrieved from our archive. We also compared the results of p63 and p40 immunoexpression and investigated the diagnostic role of p53/Rb1. Results: In our investigation, we reached a definite diagnosis with a mean number of one stain compared with six stains in the original diagnostic procedure, with a 97.3% concordance rate. Only in the case of metastases, a clear advantage is proven in the use of more stains, especially in the absence of clinical information. We also found a comparable utility of p40 and p63 for the diagnosis of squamous cell carcinoma, despite the higher p63 expression in other histological types. Moreover, normal p53/Rb1 expression could be utilized for the exclusion of small-cell LC. Conclusions: Our study confirms the diagnostic certainty achieved by the suggestions of the WHO classification and justifies the potential insecurity in the absence of adequate communication with the treating clinician. [ABSTRACT FROM AUTHOR]

Published
2024
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4. A Histological Analysis and Detection of Complement Regulatory Protein CD55 in SARS-CoV-2 Infected Lungs.

Author

Silawal, Sandeep, Gögele, Clemens, Pelikan, Petr, Werner, Christian, Levidou, Georgia, Mahato, Raman, and Schulze-Tanzil, Gundula

Subjects
ADULT respiratory distress syndrome, LUNGS, CD55 antigen, LUNG diseases, COMPLEMENT activation, CELL anatomy
Abstract

Background: A complement imbalance in lung alveolar tissue can play a deteriorating role in COVID-19, leading to acute respiratory distress syndrome (ARDS). CD55 is a transmembrane glycoprotein that inhibits the activation of the complement system at the intermediate cascade level, blocking the activity of the C3 convertase. Objective: In our study, lung specimens from COVID-19 and ARDS-positive COVID+/ARDS+ patients were compared with COVID-19 and ARDS-negative COVID–/ARDS– as well as COVID–/ARDS+ patients. Methods: Histochemical staining and immunolabeling of CD55 protein were performed. Results: The COVID–/ARDS– specimen showed higher expression and homogeneous distribution of glycosaminoglycans as well as compactly arranged elastic and collagen fibers of the alveolar walls in comparison to ARDS-affected lungs. In addition, COVID–/ARDS– lung tissues revealed stronger and homogenously distributed CD55 expression on the alveolar walls in comparison to the disrupted COVID–/ARDS+ lung tissues. Conclusions: Even though the collapse of the alveolar linings and the accumulation of cellular components in the alveolar spaces were characteristic of COVID+/ARDS+ lung tissues, evaluating CD55 expression could be relevant to understand its relation to the disease. Furthermore, targeting CD55 upregulation as a potential therapy could be an option for post-infectious complications of COVID-19 and other inflammatory lung diseases in the future. [ABSTRACT FROM AUTHOR]

Published
2024
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7. The Impact of DAXX, HJURP and CENPA Expression in Uveal Melanoma Carcinogenesis and Associations with Clinicopathological Parameters.

Author

Pergaris, Alexandros, Levidou, Georgia, Mandrakis, Georgios, Christodoulou, Maria-Ioanna, Karamouzis, Michail V., Klijanienko, Jerzy, and Theocharis, Stamatios

Subjects
HOLLIDAY junctions, PROGRESSION-free survival, OVERALL survival, CANCER prognosis, TUMOR markers
Abstract

Uveal melanomas (UMs) represent rare malignant tumors associated with grim prognosis for the majority of patients. DAXX (Death Domain-Associated Protein), HJURP (Holliday Junction Recognition Protein) and CENPA (Centromere Protein A) proteins are implicated in epigenetic mechanisms, now in the spotlight of cancer research to better understand the molecular background of tumorigenesis. Herein, we investigated their expression in UM tissues using immunohistochemistry and explored possible correlations with a multitude of clinicopathological and survival parameters. The Cancer Genome Atlas Program (TCGA) was used for the investigation of their mRNA levels in UM cases. Nuclear DAXX expression correlated with an advanced T-stage (p = 0.004), while cytoplasmic expression marginally with decreased disease-free survival (DFS) (p = 0.084). HJURP nuclear positivity also correlated with advanced T-status (p = 0.054), chromosome 3 loss (p = 0.042) and increased tumor size (p = 0.03). More importantly, both nuclear and cytoplasmic HJURP immunopositivity correlated with decreased overall survival (OS) (p = 0.011 and 0.072, respectively) and worse DFS (p = 0.071 and 0.019, respectively). Lastly, nuclear CENPA overexpression was correlated with presence of irido-corneal angle involvement (p = 0.015) and loss of chromosome 3 (p = 0.041). Nuclear and cytoplasmic CENPA immunopositivity associated with decreased OS (p = 0.028) and DFS (p = 0.018), respectively. HJURP and CENPA mRNA overexpression exhibited strong association with tumor epithelioid histology and was linked to worse prognosis. Our results show the compounding role of DAXX, HJURP and CENPA in UM carcinogenesis, designating them as potential biomarkers for assessing prognosis and possible targets for novel therapeutic interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Consensus statement of the Hellenic and Cypriot Gastric Cancer Study Group on the diagnosis, staging and management of gastric cancer

Author

Douridas, Gerasimos N., Fountoulakis, Andreas, Souglakos, John, Gourtsoyianni, Sofia, Vini, Louiza, Levidou, Georgia, Liakakos, Theodoros, Agalianos, Christos, Dervenis, Christos, Kalogeridi, Maria Angeliki, Karavokyros, Ioannis, Koumarianou, Anna, Kountourakis, Panteleimon, Oikonomopoulos, Georgios, Economopoulou, Panagiota, Sgouros, Joseph, Sgouros, Spiros N., Stamou, Konstantinos, Triantopoulou, Charikleia, Zacharoulis, Dimitrios, Gouvas, Nikolaos, and Xynos, Evangelos

Published
2020
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11. Consensus statement of the Hellenic and Cypriot Oesophageal Cancer Study Group on the diagnosis, staging and management of oesophageal cancer

Author

Fountoulakis, Andreas, Souglakos, John, Vini, Louiza, Douridas, Gerasimos N., Koumarianou, Anna, Kountourakis, Panteleimon, Agalianos, Christos, Alexandrou, Andreas, Dervenis, Christos, Gourtsoyianni, Sofia, Gouvas, Nikolaos, Kalogeridi, Maria-Angeliki, Levidou, Georgia, Liakakos, Theodoros, Sgouros, Joseph, Sgouros, Spiros N., Triantopoulou, Charikleia, and Xynos, Evangelos

Published
2019
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12. Clinical Significance of the Immunohistochemical Expression of Histone Deacetylases (HDACs)-2, -4, and -5 in Ovarian Adenocarcinomas.

Author

Levidou, Georgia, Arsenakis, Dimitrios, Bolovis, Dimitrios I., Meyer, Roxanne, Brucker, Cosima V. M., Papadopoulos, Thomas, and Theocharis, Stamatios

Subjects
OVARIAN epithelial cancer, DEACETYLASES, ADENOCARCINOMA, LYMPHATIC metastasis, HISTONE deacetylase inhibitors
Abstract

Background: Histone deacetylases (HDACs) are implicated in carcinogenesis, and HDAC inhibitors (HDACis) are explored as a therapeutic tool in several tumors. The aim of this study was to evaluate the clinical significance of HDAC-2, -4, and -5 expression in epithelial ovarian carcinoma (EOC). Methods: HDAC-2, -4, and -5 immunohistochemical expression was examined in 92 EOC tissue specimens and was correlated with clinicopathological characteristics. Results: HDAC-2 was the most frequently (94.4%) expressed isoform, being marginally higher in serous tumors compared with other types (p = 0.08). HDAC-5 was the less frequently expressed (28.1%), being positively associated with HDAC-4. HDAC-4 positivity was associated with lower FIGO-stage (p = 0.045) and T-category (p = 0.043) and the absence of lymph node (p = 0.05) or distant metastasis (p = 0.09) in serous carcinomas. HDAC-2 positivity was correlated with the absence of lymph node metastasis in serous tumors (p = 0.045). On the contrary, HDAC-5 nuclear positivity was correlated with lymph node metastasis in the entire cohort (p = 0.048). HDAC-4 positivity was marginally associated with favorable prognosis in serous carcinomas in univariate survival analysis (p = 0.086), but this correlation was not significant in multivariate analysis. Conclusions: These findings suggest a differential expression among HDAC-2, -4, and -5 in ovarian adenocarcinomas in terms of immunolocalization, positivity rate, and associations with clinicopathological parameters, providing evidence for a potential role in the pathobiology of EOC. [ABSTRACT FROM AUTHOR]

Published
2024
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21. EPHA2, EPHA4, and EPHA6 Expression in Uveal Melanomas: Searching for the Culprits of Neoplasia

Author

Pergaris, Alexandros, primary, Danas, Eugene, additional, Gajdzis, Pawel, additional, Levidou, Georgia, additional, Gajdzis, Malgorzata, additional, Cassoux, Nathalie, additional, Gardrat, Sophie, additional, Donizy, Piotr, additional, Korkolopoulou, Penelope, additional, Kavantzas, Nikolaos, additional, Klijanienko, Jerzy, additional, and Theocharis, Stamatios, additional

Published
2022
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22. CD138 Expression Helps Distinguishing Waldenström's Macroglobulinemia (WM) From Splenic Marginal Zone Lymphoma (SMZL)

Author

Kyrtsonis, Marie-Christine, Levidou, Georgia, Korkolopoulou, Penelope, Koulieris, Efstathios, Bartzi, Vassiliki, Maltezas, Dimitrios, Pangalis, Gerassimos A., Kalpadakis, Christina, Dimou, Maria, Georgiou, George, Vassilakopoulos, Theodoros P., Angelopoulou, Maria K., Salpeas, Vassilis, Tsaftaridis, Panagiotis, Patsouris, Efstratios, Panayiotidis, Panayiotis, and Tzenou, Tatiana K.

Published
2011
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26. Histone Deacetylase (HDAC)-1, -2, -4, and -6 in Uveal Melanomas: Associations with Clinicopathological Parameters and Patients’ Survival

Author

Levidou, Georgia, primary, Gajdzis, Pawel, additional, Cassoux, Nathalie, additional, Donizy, Piotr, additional, Masaoutis, Christos, additional, Gajdzis, Malgorzata, additional, Gardrat, Sophie, additional, Pergaris, Alexandros, additional, Danas, Eougken, additional, Klijanienko, Jerzy, additional, and Theocharis, Stamatios, additional

Published
2021
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29. Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer

Author

Gargalionis, Antonios N., Korkolopoulou, Penelope, Farmaki, Elena, Piperi, Christina, Dalagiorgou, Georgia, Adamopoulos, Christos, Levidou, Georgia, Saetta, Angelica, Fragkou, Paraskevi, Tsioli, Panagiota, Kiaris, Hippokratis, Zizi-Serbetzoglou, Adamantia, Karavokyros, Ioannis, Papavassiliou, Kostas A., Tsavaris, Nikolaos, Patsouris, Efstratios, Basdra, Efthimia K., and Papavassiliou, Athanasios G.

Published
2015
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30. In situ assessment of PI3K and PTEN alterations in mycosis fungoides: correlation with clinicopathological features

Author

Papadavid, Evangelia, Korkolopoulou, Penelope, Levidou, Georgia, Saetta, Angelica A., Papadaki, Theodora, Siakantaris, Marina, Nikolaou, Vassiliki, Oikonomidi, Afroditi, Chatziandreou, Ilenia, Marinos, Leonidas, Kolialexi, Aggeliki, Stratigos, Alexandros, Rigopoulos, Dimitrios, Psyrri, Amanta, Patsouris, Eftratios, and Antoniou, Christina

Published
2014
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34. Kikuchi’s lymphadenopathy: a relatively rare but important cause of lymphadenopathy in Greece, potentially associated with the antiphospholipid syndrome

Author

Vassilakopoulos, Theodoros P., Pangalis, Gerassimos A., Siakantaris, Marina P., Levidou, Georgia, Yiakoumis, Xanthi, Floudas, Charalambos, Gribabis, Despina, Bouros, Spyridon, Metaxas, Ioannis, Dimitriadou, Evangelia M., Pantazi, Lambrini, Tsoukala, Catherine, Korkolopoulou, Penelope, Andreopoulos, Anastasios, and Vaiopoulos, George

Published
2010
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45. A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma

Author

Korkolopoulou, Penelope, Levidou, Georgia, Trigka, Eleni-Andriana, Prekete, Niki, Karlou, Maria, Thymara, Irene, Sakellariou, Stratigoula, Fragkou, Paraskevi, Isaiadis, Dimitrios, Pavlopoulos, Petros, Patsouris, Efstratios, and Saetta, Angelica A.

Published
2012
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