46 results on '"Levidiotis, Vicki"'
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2. The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial
- Author
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Au Peh, Chen, Chakera, Aron, Cooper, Bruce, Kurtkoti, Jagadeesh, Langguth, Daman, Levidiotis, Vicki, Luxton, Grant, Mount, Peter, Mudge, David, Noble, Euan, Phoon, Richard, Ranganathan, Dwarakanathan, Ritchie, Angus, Ryan, Jessica, Suranyi, Michael, Rosenkranz, Alexander, Lhotta, Karl, Kronbichler, Andreas, Demoulin, Nathalie, Bovy, Christophe, Hellemans, Rachel, Hougardy, Jean-Michel, Sprangers, Ben, Wissing, Karl Martin, Pagnoux, Christian, Barbour, Sean, Brachemi, Soumeya, Cournoyer, Serge, Girard, Louis-Philippe, Laurin, Louis-Philippe, Liang, Patrick, Philibert, David, Walsh, Michael, Tesar, Vladimir, Becvar, Radim, Horak, Pavel, Rychlik, Ivan, Szpirt, Wladimir, Dieperink, Hans, Gregersen, Jon Waarst, Ivarsen, Per, Krarup, Elizabeth, Lyngsoe, Cecilie, Rigothier, Claire, Augusto, Jean-Francois, Belot, Alexandre, Chauveau, Dominique, Cornec, Divi, Jourde-Chiche, Noemie, Ficheux, Maxence, Karras, Alexandre, Klein, Alexandre, Maurier, Francois, Mesbah, Rafik, Moranne, Olivier, Neel, Antoine, Quemeneur, Thomas, Saadoun, David, Terrier, Benjamin, Zaoui, Philippe, Schaier, Matthias, Benck, Urs Tobias, Bergner, Raoul, Busch, Martin, Floege, Juergen, Grundmann, Franziska, Haller, Hermann, Haubitz, Marion, Hellmich, Bernhard, Henes, Joerg Christoph, Hohenstein, Bernd, Hugo, Christian, Iking-Konert, Christof, Arndt, Fabian, Kubacki, T, Kotter, Ina, Lamprecht, Peter, Lindner, Tom, Halbritter, Jan, Mehling, Heidrun, Schönermarck, Ulf, Venhoff, Nils, Vielhauer, Volker, Witzke, Oliver, Szombati, Istvan, Szucs, Gabriella, Garibotto, Giacomo, Alberici, Federico, Brunetta, Enrico, Dagna, Lorenzo, De Vita, Salvatore, Emmi, Giacomo, Gabrielli, Armando, Manenti, Lucio, Pieruzzi, Federico, Roccatello, Dario, Salvarani, Carlo, Harigai, Masayoshi, Dobashi, Hiroaki, Atsumi, Tatsuya, Fujimoto, Shoichi, Hagino, Noboru, Ihata, Atsushi, Kaname, Shinya, Kaneko, Yuko, Katagiri, Akira, Katayama, Masao, Kirino, Yohei, Kitagawa, Kiyoki, Komatsuda, Atsushi, Kono, Hajime, Kurasawa, Takahiko, Matsumura, Ryutaro, Mimura, Toshihide, Morinobu, Akio, Murakawa, Yohko, Naniwa, Taio, Nanki, Toshihiro, Ogawa, Noriyoshi, Oshima, Hisaji, Sada, Kenei, Sugiyama, Eiji, Takeuchi, Tohru, Taki, Hirofumi, Tamura, Naoto, Tsukamoto, Tatsuo, Yamagata, Kunihiro, Yamamura, Masahiro, van Daele, Paulus Leon Arthur, Rutgers, Abraham, Teng, Y.K. Onno, Walker, Robert, Chua, Ignatius, Collins, Michael, Rabindranath, Kannaiyan, de Zoysa, Janak, Svensson, My Hanna Sofia, Grevbo, Bard-Waldum, Kalstad, Synove, Little, Mark, Clarkson, Michael, Molloy, Eamonn, Agraz Pamplona, Irene, Anton, Jordi, Barrio Lucia, Vicente, Ciggaran, Secundino, Cinta Cid, Maria, Diaz Encarnacion, Montserrat, Fulladosa Oliveras, Xavier, Jose Soler, Maria, Marco Rusinol, Helena, Praga, Manuel, Quintana Porras, Luis, Segarra, Alfons, Bruchfeld, Annette, Segelmark, Marten, Soveri, Inga, Thomaidi, Eleni, Westman, Kerstin, Neumann, Thomas, Burnier, Michel, Daikeler, Thomas, Dudler, Jean, Hauser, Thomas, Seeger, Harald, Vogt, Bruno, Burton, James, Al Jayyousi, Reem, Amin, Tania, Andrews, Jacqueline, Baines, Laura Anne, Brogan, Paul, Dasgupta, Bhaskar, Doulton, Timothy William Ronald, Flossmann, Oliver, Griffin, Sian V., Harper, Janice Marian, Harper, Lorraine, Kidder, Dana, Klocke, Rainer, Lanyon, Peter Charles, Luqmani, Raashid, McLaren, John Stuart, Makanjuola, David Osagie, McCann, Liza, Nandagudi, Anupama C., Selvan, Shilpa, O'Riordan, Edmond, Patel, Mumtaz, Patel, Rajan Kantilal, Pusey, Charles Dickson, Rajakariar, Ravindra, Robson, Joanna C., Robson, Michael, Salama, Alan David, Smyth, Lucy, Sznajd, Jan, Taylor, Joanne, Sreih, Antonie G., Belilos, Elise, Bomback, Andrew S., Carlin, Jeffrey, Chang Chen Lin, Yih, Derebail, Vimal K., Dragoi, Serban, Dua, Anisha, Forbess, Lindsy, Geetha, Duvuru, Gipson, Patrick, Gohh, Reginald, Greenwood, Gregory Todd, Hugenberg, Steven T., Jimenez, Richard A.H., Kaskas, Marwan Omar, Kermani, Tanaz, Kivitz, Alan J., Koening, Curry, Langford, Carol A., Marder, Galina, Mohamed, Amr Ahmed El-Huesseini, Monach, Paul, Neyra, Nilda Roxana, Niemer, Gregory W., Niles, John, Obi, Reginald, Owens, Charles, Parks, Deborah L., Podoll, Amber S., Rovin, Brad, Sam, R, Shergy, William Julius, Silva, Arnold Lawrence, Specks, Ulrich, Spiera, Robert, Springer, Jason M., Striebich, Christopher Charles, Swarup, Areena, Thakar, Surabhi, Tiliakos, Athan N., Tsai, Yong, Waguespack, Dia R., Chester Wasko, Mary, Strand, Vibeke, Jayne, David R W, Horomanski, Audra, Yue, Huibin, Bekker, Pirow, and Merkel, Peter A
- Published
- 2023
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3. Results from part A of the multi-center, double-blind, randomized, placebo-controlled NefIgArd trial, which evaluated targeted-release formulation of budesonide for the treatment of primary immunoglobulin A nephropathy
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Fragale, Guillermo, Karl, Alejandra, Losisolo, Patricia, Trimarchi, Hernán, Hoyos, Ivan Gonzalez, Lampo, Mauro Guillermo, Monkowski, Matias, De La Fuente, Jorge, Alvarez, Magdalena, Stoppa, Daniela, Chiurchiu, Carlos, Novoa, Pablo Antonio, Orias, Marcelo, Barron, Maria Belen, Giotto, Ana, Arriola, Mariano, Cassini, Evelin, Maldonado, Rafael, Dionisi, Maria Paula, Ryan, Jessica, Toussaint, Nigel, Luxton, Grant, Peh, Chen Au, Levidiotis, Vicki, Francis, Ross, Phoon, Richard, Fedosiuk, Elena, Toropilov, Dmitry, Yakubtsevich, Ruslan, Mikhailova, Elena, Bovy, Christophe, Demoulin, Nathalie, Hougardy, Jean-Michel, Maes, Bart, Speeckaert, Marijn, Laurin, Louis-Philippe, Barbour, Sean, Masse, Melanie, Hladunewich, Michelle, Reich, Heather, Cournoyer, Serge, Tennankore, Karthik, Lv, Jicheng, Liu, Zhangsuo, Wang, Caili, Li, Shaomei, Luo, Qun, Ni, Zhaohui, Yan, Tiekun, Fu, Ping, Cheng, Hong, Liu, Bicheng, Lu, Wanhong, Wang, Jianqin, Chen, Qinkai, Wang, DeGuang, Xiong, Zuying, Chen, Menghua, Xu, Yan, Wei, Jiali, Pai, Pearl, Chen, Lianhua, Rehorova, Jitka, Maixnerova, Dita, Safranek, Roman, Rychlik, Ivan, Hruby, Miroslav, Makela, Satu, Vaaraniemi, Kati, Ortiz, Fernanda, Alamartine, Eric, Daroux, Maite, Cartery, Claire, Vrtovsnik, Francois, Serre, Jean-Emmanuel, Stamellou, Eleni, Vielhauer, Volker, Hugo, Christian, Budde, Klemens, Otte, Britta, Nitschke, Martin, Ntounousi, Evangelia, Boletis, Ioannis, Papagianni, Aikaterini, Goumenos, Dimitrios, Stylianou, Konstantinos, Zermpala, Synodi, Esposito, Ciro, Cozzolino, Mario Gennaro, Viganò, Sara Maria, Gesualdo, Loreto, Nowicki, Michal, Stompor, Tomasz, Kurnatowska, Ilona, Kim, Sung Gyun, Kim, Yong-Lim, Na, Ki-Ryang, Kim, Dong Ki, Kim, Su-Hyun, Porras, Luis Quintana, Garcia, Eva Rodriguez, Pamplona, Irene Agraz, Segarra, Alfons, Goicoechea, Marian, Fellstrom, Bengt, Lundberg, Sigrid, Hemmingsson, Peter, Guron, Gregor, Sandell, Anna, Chen, Cheng-Hsu, Tokgoz, Bulent, Duman, Soner, Altiparmak, Mehmet Riza, Ergul, Metin, Maxwell, Peter, Mark, Patrick, McCafferty, Kieran, Khwaja, Arif, Cheung, Chee Kay, Hall, Matthew, Power, Albert, Kanigicherla, Durga, Baker, Richard, Moriarty, Jim, Mohamed, Amr, Aiello, Joseph, Canetta, Pietro, Ayoub, Isabelle, Robinson, Derrick, Thakar, Surabhi, Mottl, Amy, Sachmechi, Isaac, Fischbach, Bernard, Singh, Harmeet, Mulhern, Jeffrey, Kamal, Fahmeedah, Linfert, Douglas, Rizk, Dana, Wadhwani, Shikha, Sarav, Menaka, Campbell, Kirk, Coppock, Gaia, Luciano, Randy, Sedor, John, Avasare, Rupali, Lau, Wai Lang, Barratt, Jonathan, Lafayette, Richard, Kristensen, Jens, Stone, Andrew, Cattran, Daniel, Floege, Jürgen, Tesar, Vladimir, Zhang, Hong, Eren, Necmi, Paliege, Alexander, and Rovin, Brad H.
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- 2023
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4. Case report of the successful use of semaglutide to achieve target BMI prior to renal transplant in two patients with end‐stage‐kidney‐disease
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Wallace, Rory, primary, Hamblin, Peter Shane, additional, Tully, Emma, additional, Tran, Julina, additional, Nelson, Craig, additional, and Levidiotis, Vicki, additional
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- 2024
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5. The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial
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Strand, Vibeke, primary, Jayne, David R W, additional, Horomanski, Audra, additional, Yue, Huibin, additional, Bekker, Pirow, additional, Merkel, Peter A, additional, Au Peh, Chen, additional, Chakera, Aron, additional, Cooper, Bruce, additional, Kurtkoti, Jagadeesh, additional, Langguth, Daman, additional, Levidiotis, Vicki, additional, Luxton, Grant, additional, Mount, Peter, additional, Mudge, David, additional, Noble, Euan, additional, Phoon, Richard, additional, Ranganathan, Dwarakanathan, additional, Ritchie, Angus, additional, Ryan, Jessica, additional, Suranyi, Michael, additional, Rosenkranz, Alexander, additional, Lhotta, Karl, additional, Kronbichler, Andreas, additional, Demoulin, Nathalie, additional, Bovy, Christophe, additional, Hellemans, Rachel, additional, Hougardy, Jean-Michel, additional, Sprangers, Ben, additional, Wissing, Karl Martin, additional, Pagnoux, Christian, additional, Barbour, Sean, additional, Brachemi, Soumeya, additional, Cournoyer, Serge, additional, Girard, Louis-Philippe, additional, Laurin, Louis-Philippe, additional, Liang, Patrick, additional, Philibert, David, additional, Walsh, Michael, additional, Tesar, Vladimir, additional, Becvar, Radim, additional, Horak, Pavel, additional, Rychlik, Ivan, additional, Szpirt, Wladimir, additional, Dieperink, Hans, additional, Gregersen, Jon Waarst, additional, Ivarsen, Per, additional, Krarup, Elizabeth, additional, Lyngsoe, Cecilie, additional, Rigothier, Claire, additional, Augusto, Jean-Francois, additional, Belot, Alexandre, additional, Chauveau, Dominique, additional, Cornec, Divi, additional, Jourde-Chiche, Noemie, additional, Ficheux, Maxence, additional, Karras, Alexandre, additional, Klein, Alexandre, additional, Maurier, Francois, additional, Mesbah, Rafik, additional, Moranne, Olivier, additional, Neel, Antoine, additional, Quemeneur, Thomas, additional, Saadoun, David, additional, Terrier, Benjamin, additional, Zaoui, Philippe, additional, Schaier, Matthias, additional, Benck, Urs Tobias, additional, Bergner, Raoul, additional, Busch, Martin, additional, Floege, Juergen, additional, Grundmann, Franziska, additional, Haller, Hermann, additional, Haubitz, Marion, additional, Hellmich, Bernhard, additional, Henes, Joerg Christoph, additional, Hohenstein, Bernd, additional, Hugo, Christian, additional, Iking-Konert, Christof, additional, Arndt, Fabian, additional, Kubacki, T, additional, Kotter, Ina, additional, Lamprecht, Peter, additional, Lindner, Tom, additional, Halbritter, Jan, additional, Mehling, Heidrun, additional, Schönermarck, Ulf, additional, Venhoff, Nils, additional, Vielhauer, Volker, additional, Witzke, Oliver, additional, Szombati, Istvan, additional, Szucs, Gabriella, additional, Garibotto, Giacomo, additional, Alberici, Federico, additional, Brunetta, Enrico, additional, Dagna, Lorenzo, additional, De Vita, Salvatore, additional, Emmi, Giacomo, additional, Gabrielli, Armando, additional, Manenti, Lucio, additional, Pieruzzi, Federico, additional, Roccatello, Dario, additional, Salvarani, Carlo, additional, Harigai, Masayoshi, additional, Dobashi, Hiroaki, additional, Atsumi, Tatsuya, additional, Fujimoto, Shoichi, additional, Hagino, Noboru, additional, Ihata, Atsushi, additional, Kaname, Shinya, additional, Kaneko, Yuko, additional, Katagiri, Akira, additional, Katayama, Masao, additional, Kirino, Yohei, additional, Kitagawa, Kiyoki, additional, Komatsuda, Atsushi, additional, Kono, Hajime, additional, Kurasawa, Takahiko, additional, Matsumura, Ryutaro, additional, Mimura, Toshihide, additional, Morinobu, Akio, additional, Murakawa, Yohko, additional, Naniwa, Taio, additional, Nanki, Toshihiro, additional, Ogawa, Noriyoshi, additional, Oshima, Hisaji, additional, Sada, Kenei, additional, Sugiyama, Eiji, additional, Takeuchi, Tohru, additional, Taki, Hirofumi, additional, Tamura, Naoto, additional, Tsukamoto, Tatsuo, additional, Yamagata, Kunihiro, additional, Yamamura, Masahiro, additional, van Daele, Paulus Leon Arthur, additional, Rutgers, Abraham, additional, Teng, Y.K. Onno, additional, Walker, Robert, additional, Chua, Ignatius, additional, Collins, Michael, additional, Rabindranath, Kannaiyan, additional, de Zoysa, Janak, additional, Svensson, My Hanna Sofia, additional, Grevbo, Bard-Waldum, additional, Kalstad, Synove, additional, Little, Mark, additional, Clarkson, Michael, additional, Molloy, Eamonn, additional, Agraz Pamplona, Irene, additional, Anton, Jordi, additional, Barrio Lucia, Vicente, additional, Ciggaran, Secundino, additional, Cinta Cid, Maria, additional, Diaz Encarnacion, Montserrat, additional, Fulladosa Oliveras, Xavier, additional, Jose Soler, Maria, additional, Marco Rusinol, Helena, additional, Praga, Manuel, additional, Quintana Porras, Luis, additional, Segarra, Alfons, additional, Bruchfeld, Annette, additional, Segelmark, Marten, additional, Soveri, Inga, additional, Thomaidi, Eleni, additional, Westman, Kerstin, additional, Neumann, Thomas, additional, Burnier, Michel, additional, Daikeler, Thomas, additional, Dudler, Jean, additional, Hauser, Thomas, additional, Seeger, Harald, additional, Vogt, Bruno, additional, Burton, James, additional, Al Jayyousi, Reem, additional, Amin, Tania, additional, Andrews, Jacqueline, additional, Baines, Laura Anne, additional, Brogan, Paul, additional, Dasgupta, Bhaskar, additional, Doulton, Timothy William Ronald, additional, Flossmann, Oliver, additional, Griffin, Sian V., additional, Harper, Janice Marian, additional, Harper, Lorraine, additional, Kidder, Dana, additional, Klocke, Rainer, additional, Lanyon, Peter Charles, additional, Luqmani, Raashid, additional, McLaren, John Stuart, additional, Makanjuola, David Osagie, additional, McCann, Liza, additional, Nandagudi, Anupama C., additional, Selvan, Shilpa, additional, O'Riordan, Edmond, additional, Patel, Mumtaz, additional, Patel, Rajan Kantilal, additional, Pusey, Charles Dickson, additional, Rajakariar, Ravindra, additional, Robson, Joanna C., additional, Robson, Michael, additional, Salama, Alan David, additional, Smyth, Lucy, additional, Sznajd, Jan, additional, Taylor, Joanne, additional, Sreih, Antonie G., additional, Belilos, Elise, additional, Bomback, Andrew S., additional, Carlin, Jeffrey, additional, Chang Chen Lin, Yih, additional, Derebail, Vimal K., additional, Dragoi, Serban, additional, Dua, Anisha, additional, Forbess, Lindsy, additional, Geetha, Duvuru, additional, Gipson, Patrick, additional, Gohh, Reginald, additional, Greenwood, Gregory Todd, additional, Hugenberg, Steven T., additional, Jimenez, Richard A.H., additional, Kaskas, Marwan Omar, additional, Kermani, Tanaz, additional, Kivitz, Alan J., additional, Koening, Curry, additional, Langford, Carol A., additional, Marder, Galina, additional, Mohamed, Amr Ahmed El-Huesseini, additional, Monach, Paul, additional, Neyra, Nilda Roxana, additional, Niemer, Gregory W., additional, Niles, John, additional, Obi, Reginald, additional, Owens, Charles, additional, Parks, Deborah L., additional, Podoll, Amber S., additional, Rovin, Brad, additional, Sam, R, additional, Shergy, William Julius, additional, Silva, Arnold Lawrence, additional, Specks, Ulrich, additional, Spiera, Robert, additional, Springer, Jason M., additional, Striebich, Christopher Charles, additional, Swarup, Areena, additional, Thakar, Surabhi, additional, Tiliakos, Athan N., additional, Tsai, Yong, additional, Waguespack, Dia R., additional, and Chester Wasko, Mary, additional
- Published
- 2023
- Full Text
- View/download PDF
6. Results from part A of the multi-center, double-blind, randomized, placebo-controlled NefIgArd trial, which evaluated targeted-release formulation of budesonide for the treatment of primary immunoglobulin A nephropathy
- Author
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Barratt, Jonathan, primary, Lafayette, Richard, additional, Kristensen, Jens, additional, Stone, Andrew, additional, Cattran, Daniel, additional, Floege, Jürgen, additional, Tesar, Vladimir, additional, Trimarchi, Hernán, additional, Zhang, Hong, additional, Eren, Necmi, additional, Paliege, Alexander, additional, Rovin, Brad H., additional, Fragale, Guillermo, additional, Karl, Alejandra, additional, Losisolo, Patricia, additional, Hoyos, Ivan Gonzalez, additional, Lampo, Mauro Guillermo, additional, Monkowski, Matias, additional, De La Fuente, Jorge, additional, Alvarez, Magdalena, additional, Stoppa, Daniela, additional, Chiurchiu, Carlos, additional, Novoa, Pablo Antonio, additional, Orias, Marcelo, additional, Barron, Maria Belen, additional, Giotto, Ana, additional, Arriola, Mariano, additional, Cassini, Evelin, additional, Maldonado, Rafael, additional, Dionisi, Maria Paula, additional, Ryan, Jessica, additional, Toussaint, Nigel, additional, Luxton, Grant, additional, Peh, Chen Au, additional, Levidiotis, Vicki, additional, Francis, Ross, additional, Phoon, Richard, additional, Fedosiuk, Elena, additional, Toropilov, Dmitry, additional, Yakubtsevich, Ruslan, additional, Mikhailova, Elena, additional, Bovy, Christophe, additional, Demoulin, Nathalie, additional, Hougardy, Jean-Michel, additional, Maes, Bart, additional, Speeckaert, Marijn, additional, Laurin, Louis-Philippe, additional, Barbour, Sean, additional, Masse, Melanie, additional, Hladunewich, Michelle, additional, Reich, Heather, additional, Cournoyer, Serge, additional, Tennankore, Karthik, additional, Lv, Jicheng, additional, Liu, Zhangsuo, additional, Wang, Caili, additional, Li, Shaomei, additional, Luo, Qun, additional, Ni, Zhaohui, additional, Yan, Tiekun, additional, Fu, Ping, additional, Cheng, Hong, additional, Liu, Bicheng, additional, Lu, Wanhong, additional, Wang, Jianqin, additional, Chen, Qinkai, additional, Wang, DeGuang, additional, Xiong, Zuying, additional, Chen, Menghua, additional, Xu, Yan, additional, Wei, Jiali, additional, Pai, Pearl, additional, Chen, Lianhua, additional, Rehorova, Jitka, additional, Maixnerova, Dita, additional, Safranek, Roman, additional, Rychlik, Ivan, additional, Hruby, Miroslav, additional, Makela, Satu, additional, Vaaraniemi, Kati, additional, Ortiz, Fernanda, additional, Alamartine, Eric, additional, Daroux, Maite, additional, Cartery, Claire, additional, Vrtovsnik, Francois, additional, Serre, Jean-Emmanuel, additional, Stamellou, Eleni, additional, Vielhauer, Volker, additional, Hugo, Christian, additional, Budde, Klemens, additional, Otte, Britta, additional, Nitschke, Martin, additional, Ntounousi, Evangelia, additional, Boletis, Ioannis, additional, Papagianni, Aikaterini, additional, Goumenos, Dimitrios, additional, Stylianou, Konstantinos, additional, Zermpala, Synodi, additional, Esposito, Ciro, additional, Cozzolino, Mario Gennaro, additional, Viganò, Sara Maria, additional, Gesualdo, Loreto, additional, Nowicki, Michal, additional, Stompor, Tomasz, additional, Kurnatowska, Ilona, additional, Kim, Sung Gyun, additional, Kim, Yong-Lim, additional, Na, Ki-Ryang, additional, Kim, Dong Ki, additional, Kim, Su-Hyun, additional, Porras, Luis Quintana, additional, Garcia, Eva Rodriguez, additional, Pamplona, Irene Agraz, additional, Segarra, Alfons, additional, Goicoechea, Marian, additional, Fellstrom, Bengt, additional, Lundberg, Sigrid, additional, Hemmingsson, Peter, additional, Guron, Gregor, additional, Sandell, Anna, additional, Chen, Cheng-Hsu, additional, Tokgoz, Bulent, additional, Duman, Soner, additional, Altiparmak, Mehmet Riza, additional, Ergul, Metin, additional, Maxwell, Peter, additional, Mark, Patrick, additional, McCafferty, Kieran, additional, Khwaja, Arif, additional, Cheung, Chee Kay, additional, Hall, Matthew, additional, Power, Albert, additional, Kanigicherla, Durga, additional, Baker, Richard, additional, Moriarty, Jim, additional, Mohamed, Amr, additional, Aiello, Joseph, additional, Canetta, Pietro, additional, Ayoub, Isabelle, additional, Robinson, Derrick, additional, Thakar, Surabhi, additional, Mottl, Amy, additional, Sachmechi, Isaac, additional, Fischbach, Bernard, additional, Singh, Harmeet, additional, Mulhern, Jeffrey, additional, Kamal, Fahmeedah, additional, Linfert, Douglas, additional, Rizk, Dana, additional, Wadhwani, Shikha, additional, Sarav, Menaka, additional, Campbell, Kirk, additional, Coppock, Gaia, additional, Luciano, Randy, additional, Sedor, John, additional, Avasare, Rupali, additional, and Lau, Wai Lang, additional
- Published
- 2023
- Full Text
- View/download PDF
7. Co-design of a question prompt list about pregnancy and childbearing for women with polycystic kidney disease:an exploratory sequential mixed-methods study
- Author
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Holton, Sara, Nelson, Craig, Rasmussen, Bodil, Levidiotis, Vicki, Holton, Sara, Nelson, Craig, Rasmussen, Bodil, and Levidiotis, Vicki
- Abstract
Background: Although women with polycystic kidney disease (PKD) generally have healthy pregnancies and babies, pregnancy is associated with a greater risk of maternal complications and requires planning and management of their condition. Given these possible complications, routine communication about childbearing between women with PKD and their treating team is important. A question prompt list (QPL), a structured list of questions used by patients during consultations with healthcare providers, may be beneficial in assisting women with PKD to discuss their childbearing concerns with, and seek related information from, their treating team. The aims of this study were to co‐design a QPL about pregnancy and childbearing for women with PKD, and evaluate its comprehensibility, salience, and acceptability. Methods: An exploratory sequential mixed‐methods study of women of reproductive age with PKD living in Australia, using an experience‐based co‐design approach with two phases. Women were recruited from a metropolitan public health service and via social media and invited to complete an anonymous online survey about the development of the PKD QPL (phase one) and participate in an online discussion group about its refinement (phase two). Results: Sixteen women completed the development survey and seven participated in the evaluation discussion group. Participants reported that women with PKD would value and use a QPL to prompt discussions with and seek further information about pregnancy and childbearing from their healthcare providers. Women identified four main topics for the QPL: ‘thinking about having a baby’, ‘pregnancy’, ‘my medications’ and ‘after my baby is born’. Within each section a series of questions was developed. Based on the findings, a QPL about pregnancy and childbearing for women with PKD was co-designed. Conclusions: Women with PKD often find it difficult to access information and have discussions with their health care providers about pregnancy a
- Published
- 2023
8. The Overuse, Underuse, and Misuse of Dialysis in ESKD Patients with Dementia
- Author
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MacPhail, Aleece, Ibrahim, Joseph E., Fetherstonhaugh, Deirdre, and Levidiotis, Vicki
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- 2015
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9. Low salt concentrations activate AMP-activated protein kinase in mouse macula densa cells
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Cook, Natasha, Fraser, Scott A., Katerelos, Marina, Katsis, Frosa, Gleich, Kurt, Mount, Peter F., Steinberg, Gregory R., Levidiotis, Vicki, Kemp, Bruce E., and Power, David A.
- Subjects
Enzyme inhibitors -- Health aspects ,Enzyme inhibitors -- Research ,Phosphorylation -- Physiological aspects ,Phosphorylation -- Research ,Protein kinases -- Physiological aspects ,Protein kinases -- Research ,Carrier proteins -- Physiological aspects ,Carrier proteins -- Research ,Biological sciences - Abstract
The energy-sensing kinase AMP-activated protein kinase (AMPK) is associated with the sodium-potassium-chloride cotransporter NKCC2 in the kidney and phosphorylates it on a regulatory site in vitro. To identify a potential role for AMPK in salt sensing at the macula densa, we have used the murine macula densa cell line MMDD1. In this cell line, AMPK was rapidly activated by isosmolar low-salt conditions. In contrast to the known salt-sensing pathway in the macula densa, AMPK activation occurred in the presence of either low sodium or low chloride and was unaffected by inhibition of NKCC2 with bumetanide. Assays using recombinant AMPK demonstrated activation of an upstream kinase by isosmolar low salt. The specific calcium/calmodulin-dependent kinase kinase inhibitor STO-609 failed to suppress AMPK activation, suggesting that it was not part of the signal pathway. AMPK activation was associated with increased phosphorylation of the specific substrate acetyl-CoA carboxylase (ACC) at [Ser.sup.79], as well as increased NKCC2 phosphorylation at [Ser.sup.126]. AMPK activation due to low salt concentrations was inhibited by an adenovirus construct encoding a kinase dead mutant of AMPK, leading to reduced ACC [Ser.sup.79] and NKCC2 [Ser.sup.126] phosphorylation. This work demonstrates that AMPK activation in macula densa-like cells occurs via isosmolar changes in sodium or chloride concentration, leading to phosphorylation of ACC and NKCC2. Phosphorylation of these substrates in vivo is predicted to increase intracellular chloride and so reduce the effect of salt restriction on tubuloglomerular feedback and renin secretion. AMPK; NKCC2; phosphorylation; sodium reabsorption
- Published
- 2009
10. Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-[Ser.sup.1177]
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Mount, Peter F., Hill, Rebecca E., Fraser, Scott A., Levidiotis, Vicki, Katsis, Frosa, Kemp, Bruce E., and Power, David A.
- Subjects
Kidney diseases -- Physiological aspects ,Nitric oxide -- Physiological aspects ,Nitric oxide -- Chemical properties ,Phosphorylation -- Chemical properties ,Biological sciences - Abstract
A fundamental aspect of acute renal ischemia is energy depletion, manifest as a falling level of ATP that is associated with a simultaneous rise in AMP. The energy sensor AMP-activated protein kinase (AMPK) is activated by a rising AMP-to-ATP ratio, but its role in acute renal ischemia is unknown. AMPK is activated in the ischemic heart and is reported to phosphorylate both endothelial nitric oxide synthase (eNOS) and acetyl-CoA carboxylase. To study activation of AMPK in acute renal ischemia, the renal pedicle of anesthetized Sprague-Dawley rats was cross-clamped for increasing time intervals. AMPK was strongly activated within 1 min and remained so after 30 min. However, despite the robust activation of AMPK, acute renal ischemia did not increase phosphorylation of the AMPK phosphorylation sites eNOS-[Ser.sup.1177] or acetyl-CoA carboxylase-[Ser.sup.79]. Activation of AMPK in bovine aortic endothelial cells by the ATP-depleting agent antimycin A and the antidiabetic drug phenformin also did not increase phosphorylation of eNOS-[Ser.sup.1177], confirming that AMPK activation and phosphorylation of eNOS are dissociated in some situations. Immunoprecipitation studies demonstrated that the dissociation between AMPK activation and phosphorylation of eNOS-[Ser.sup.1177] was not due to changes in the physical associations between AMPK, eNOS, or heat shock protein 90. In conclusion, acute renal ischemia rapidly activates the energy sensor AMPK, which is known to maintain ATP reserves during energy stress. The substrates it phosphorylates, however, are different from those in other organs such as the heart. AMP-activated protein kinase; endothelial nitric oxide synthase; acetyl-CoA carboxylase; kidney
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- 2005
11. An observational outcomes study from 1966–2008, examining pregnancy and neonatal outcomes from dialysed women using data from the ANZDATA Registry
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SHAHIR, AHMED KAITHAL, BRIGGS, NANCY, KATSOULIS, JOHN, and LEVIDIOTIS, VICKI
- Published
- 2013
- Full Text
- View/download PDF
12. New Approaches to the Treatment of Dense Deposit Disease
- Author
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Smith, Richard J.H., Alexander, Jessy, Barlow, Paul N., Botto, Marina, Cassavant, Thomas L., Cook, H. Terence, de[Combining Acute Accent]rdoba, Santiago Rodriguez, Hageman, Gregory S., Jokiranta, T. Sakari, Kimberling, William J., Lambris, John D., Lanning, Lynne D., Levidiotis, Vicki, Licht, Christoph, Lutz, Hans U., Meri, Seppo, Pickering, Matthew C., Quigg, Richard J., Rops, Angelique L., Salant, David J., Sethi, Sanjeev, Thurman, Joshua M., Tully, Hope F., Tully, Sean P., van der Vlag, Johan, Walker, Patrick D., Wu[Combining Diaeresis]rzner, Reinhard, and Zipfel, Peter F.
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- 2007
- Full Text
- View/download PDF
13. Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells
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KANELLIS, JOHN, KANDANE, RANGI K, ETEMADMOGHADAM, DARIUSH, FRASER, SCOTT A, MOUNT, PETER F, LEVIDIOTIS, VICKI, KEMP, BRUCE E, and POWER, DAVID A
- Published
- 2006
14. New insights into the molecular biology of the glomerular filtration barrier and associated disease
- Author
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LEVIDIOTIS, VICKI and POWER, DAVID A
- Published
- 2005
15. Heparanase inhibition reduces proteinuria in a model of accelerated anti-glomerular basement membrane antibody disease
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LEVIDIOTIS, VICKI, FREEMAN, CRAIG, TIKELLIS, CHRIS, COOPER, MARK E, and POWER, DAVID A
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- 2005
16. A Synthetic Heparanase Inhibitor Reduces Proteinuria in Passive Heymann Nephritis
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Levidiotis, Vicki, Freeman, Craig, Punler, Malcolm, Martinello, Paul, Creese, Brian, Ferro, Vito, van der Vlag, Johan, Berden, Jo H.M., Parish, Christopher R., and Power, David A.
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- 2004
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17. Heparanase Is Involved in the Pathogenesis of Proteinuria as a Result of Glomerulonephritis
- Author
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Levidiotis, Vicki, Freeman, Craig, Tikellis, Chris, Cooper, Mark E., and Power, David A.
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- 2004
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- View/download PDF
18. Increased expression of HB-EGF and its receptor erbB4/HER4 in accelerated anti-GBM disease
- Author
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LEVIDIOTIS, VICKI, KHONG, TEE FERN, KATERELOS, MARINA, FRASER, SCOTT, and POWER, DAVID ANTHONY
- Published
- 2002
19. Increased expression of heparanase in puromycin aminonucleoside nephrosis
- Author
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Levidiotis, Vicki, Kanellis, John, Ierino, Frank L., and Power, David A.
- Published
- 2001
20. International statistical classification of diseases and related health problems coding underestimates the incidence and prevalence of acute kidney injury and chronic kidney disease in general medical patients
- Author
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Ko, Soe, Venkatesan, Sudharsan, Nand, Kushma, Levidiotis, Vicki, Nelson, Craig, Janus, Edward, Ko, Soe, Venkatesan, Sudharsan, Nand, Kushma, Levidiotis, Vicki, Nelson, Craig, and Janus, Edward
- Published
- 2018
21. International statistical classification of diseases and related health problems coding underestimates the incidence and prevalence of acute kidney injury and chronic kidney disease in general medical patients
- Author
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Ko, Soe, primary, Venkatesan, Sudharsan, additional, Nand, Kushma, additional, Levidiotis, Vicki, additional, Nelson, Craig, additional, and Janus, Edward, additional
- Published
- 2018
- Full Text
- View/download PDF
22. [114-POS]
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Idel, Irena, primary, Chen, Ben, additional, Nankervis, Alison, additional, Cullinane, Fiona, additional, de Crespigny, Paul Champion, additional, Levidiotis, Vicki, additional, Liew, Danny, additional, and McMahon, Lawrence, additional
- Published
- 2015
- Full Text
- View/download PDF
23. Estimated GFR Reporting Influences Recommendations for Dialysis Initiation
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Brimble, K. Scott, primary, Mehrotra, Rajnish, additional, Tonelli, Marcello, additional, Hawley, Carmel M., additional, Castledine, Clare, additional, McDonald, Stephen P., additional, Levidiotis, Vicki, additional, Gangji, Azim S., additional, Treleaven, Darin J., additional, Margetts, Peter J., additional, and Walsh, Michael, additional
- Published
- 2013
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- View/download PDF
24. Tubulointerstital nephritis and uveitis syndrome: Sore eyes and sick kidneys
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Lim, Andy K.H., Roberts, Matthew A., Joon, Troy Lim, and Levidiotis, Vicki
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Nephritis -- Diagnosis ,Nephritis -- Care and treatment ,Uveitis -- Diagnosis ,Uveitis -- Care and treatment ,Kidney diseases -- Diagnosis ,Kidney diseases -- Care and treatment ,Health - Abstract
Two cases of Tubulointerstitial nephritis and uveitis syndrome (TINU) are reported, which requires identification of acute interstitial nephritis and uveitis, in the absence of systemic diseases associated with either condition. Both patients demonstrated features of proximal tubular dysfunction consistent with Fanconi's syndrome.
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- 2005
25. [117-POS]: Neonatal outcomes in babies of mother with type 1 diabetes with and without preeclampsia
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Idel, Irena, McMahon, Lawrence, Chen, Ben, Liew, Danny, Cullinane, Fiona, Levidiotis, Vicki, de Crespigny, Paul Champion, Hopkins, Stephanie, Hunter-Smith, Sarah, and Nankervis, Alison
- Published
- 2015
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- View/download PDF
26. [114-POS] : Are reduced first trimester PAPP-A concentrations in women with Type 1 diabetes associated with preeclampsia, premature delivery, and small for gestational age infants?
- Author
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Idel, Irena, Chen, Ben, Nankervis, Alison, Cullinane, Fiona, de Crespigny, Paul Champion, Levidiotis, Vicki, Liew, Danny, and McMahon, Lawrence
- Published
- 2015
- Full Text
- View/download PDF
27. T13.3 The role of neutrophil gelatinase-associated lipocalin, soluble fms-like tyrosine kinase-1, placental growth factor and endoglin in predicting preeclampsia
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Rutherford, David, primary, Lee, Gaksoo, additional, Adno, Alan, additional, Levidiotis, Vicki, additional, Hennessy, Annemarie, additional, and Makris, Angela, additional
- Published
- 2010
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28. Corticosteroids Worsen Proteinuria and Increase Intraglomerular Signaling by NF-ĸB in a Model of Membranous Glomerulonephritis
- Author
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Mudge, Stuart J., primary, Paizis, Kathy, additional, Auwardt, Russell B., additional, Levidiotis, Vicki, additional, Fraser, Scott A., additional, and Power, David A., additional
- Published
- 2010
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29. Reduction in renal ACE2 expression in subtotal nephrectomy in rats is ameliorated with ACE inhibition
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Velkoska, Elena, primary, Dean, Rachael G., additional, Burchill, Luke, additional, Levidiotis, Vicki, additional, and Burrell, Louise M., additional
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- 2009
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30. Pregnancy and Maternal Outcomes Among Kidney Transplant Recipients
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Levidiotis, Vicki, primary, Chang, Sean, additional, and McDonald, Stephen, additional
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- 2009
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31. Dentritic cell derived IL-18 production is inhibited by rapamycin and sanglifehrin A, but not cyclosporine A
- Author
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Ko, Hungta, primary, Hambly, Brett D., additional, Eris, Josette M., additional, Levidiotis, Vicki, additional, Wyburn, Kate, additional, Wu, Huiling, additional, Chadban, Steve J., additional, and Yin, Jian L., additional
- Published
- 2008
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- View/download PDF
32. Predictors of Early Dialysis Vascular-Access Failure after Thrombolysis
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Crikis, Sandra, primary, Lee, Darren, additional, Brooks, Mark, additional, Power, David A., additional, Ierino, Francesco L., additional, and Levidiotis, Vicki, additional
- Published
- 2007
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- View/download PDF
33. Regulation of the renal-specific Na+–K+–2Cl− co-transporter NKCC2 by AMP-activated protein kinase (AMPK)
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Fraser, Scott A., primary, Gimenez, Ignacio, additional, Cook, Natasha, additional, Jennings, Ian, additional, Katerelos, Marina, additional, Katsis, Frosa, additional, Levidiotis, Vicki, additional, Kemp, Bruce E., additional, and Power, David A., additional
- Published
- 2007
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- View/download PDF
34. Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells
- Author
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Kanellis, John, primary, Kandane, Rangi K, additional, Etemadmoghadam, Dariush, additional, Fraser, Scott A, additional, Mount, Peter F, additional, Levidiotis, Vicki, additional, Kemp, Bruce E, additional, and Power, David A, additional
- Published
- 2005
- Full Text
- View/download PDF
35. An unexpected cause of macroscopic haematuria
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Lubel, John S, primary, Burrell, Louise M, additional, and Levidiotis, Vicki, additional
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- 2005
- Full Text
- View/download PDF
36. Regulation of the energy sensor AMP-activated protein kinase in the kidney by dietary salt intake and osmolality
- Author
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Fraser, Scott, primary, Mount, Peter, additional, Hill, Rebecca, additional, Levidiotis, Vicki, additional, Katsis, Frosa, additional, Stapleton, David, additional, Kemp, Bruce E., additional, and Power, David A., additional
- Published
- 2005
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- View/download PDF
37. A Study of VEGF and Its Receptors in Two Rat Models of Proteinuria
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Kanellis, John, primary, Levidiotis, Vicki, additional, Khong, Tiffany, additional, Cox, Alison J., additional, Stacker, Steven A., additional, Gilbert, Richard E., additional, Cooper, Mark E., additional, and Power, David A., additional
- Published
- 2004
- Full Text
- View/download PDF
38. Corticosteroids Worsen Proteinuria and Increase Intraglomerular Signaling by NF-κB in a Model of Membranous Glomerulonephritis.
- Author
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Mudge, Stuart J., Paizis, Kathy, Auwardt, Russell B., Levidiotis, Vicki, Fraser, Scott A., and Power, David A.
- Subjects
CORTICOSTEROIDS ,PROTEINURIA ,GLOMERULONEPHRITIS ,KIDNEY glomerulus ,DEXAMETHASONE ,IMMUNE response - Abstract
Background/Aims: Passive Heymann nephritis (PHN) is a model of human membranous glomerulonephritis characterized by heavy proteinuria. We have recently demonstrated activation of NF-κB by podocytes in this model. In this study, therefore, we have determined whether dexamethasone (DEX) and pyrrolidine dithiocarbamate (PDTC), therapies that inhibit NF-κB, influence proteinuria. Methods: Twenty-one days after induction of PHN, rats were divided into three groups: group 1 received saline, group 2 received DEX for 7 days, and group 3 received PDTC for 7 days. The effects of these drugs on activation of NF-κB and proteinuria were then determined. Results: DEX administration was associated with a very significant increase in proteinuria, whereas PDTC produced a slight decrease. Within the glomerulus, both agents were associated with increased levels of IL-1β mRNA and protein, compared with untreated rats, and there was increased nuclear localization of p50 in both of the treated groups. Neither agent, therefore, inhibited NF-κB activation within the glomerulus. Both agents produced a decrease in the systemic anti-sheep Ig immune response, and there was reduced interstitial αβ T-cell infiltration compared with controls. Conclusion: These data suggest that agents predicted to inhibit NF-κB might have opposing effects in membranous glomerulonephritis. The use of steroids to treat membranous glomerulonephritis, therefore, might produce unpredictable results, depending on whether suppression of the systemic immune response or inflammatory events within the kidney is more important in a particular patient. Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
39. Predictors of Early Dialysis Vascular-Access Failure after Thrombolysis.
- Author
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Crikis, Sandra, Lee, Darren, Brooks, Mark, Power, David A., Ierino, Francesco L., and Levidiotis, Vicki
- Abstract
Background: Vascular-access patency is critical for effective and uninterrupted haemodialysis. Limited literature exists evaluating if a surgical or repeated radiological approach is superior for reocclusion following failure of radiological recanalization. Few consistent early predictors of failure have been identified after radiological intervention for thrombosed vascular access. Methods: 138 patients with thrombosed arteriovenous fistulas or prosthetic grafts treated by radiological intervention, over 10 years, were retrospectively investigated. Reocclusion was treated by either repeated thrombolysis or surgery. Radiological patency rates, after first and second episodes of access thrombosis at 12 months after intervention were analysed. Surgical and radiological patency rates for second access thrombosis were compared. The Cox and logistic regression models were used to identify potential factors associated with reocclusion. Results: In patients who experienced reocclusion within 1 month after radiological intervention, the 3-month repeated radiological patency rate (n = 13) was 38.5%, compared to a 60% surgical patency rate (n = 10), but this did not reach statistical significance. Radiological patency rates after first access thrombosis at 3 and 12 months were 56.6 and 39.5%, respectively. In contrast, radiological patency rates after a second access thrombosis were 51.1 and 24.4%, respectively; a statistical difference in success was not achieved. Native arteriovenous fistulas were 3.23 times as likely to remain patent over 12 months following a first radiological intervention (p < 0.02) and less likely to experience a second reocclusion event (p < 0.01). Anticoagulation was associated with a lower risk of second reocclusion, whilst a history of venous thrombosis was associated with a greater risk (p < 0.02). Conclusion: Surgery achieves superior patency rates compared to repeated radiological interventions and should be considered if reocclusion occurs within a month following radiological thrombolysis. Copyright © 2007 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
40. Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser1177.
- Author
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Mount, Peter F., Hill, Rebecca E., Fraser, Scott A., Levidiotis, Vicki, Katsis, Frosa, Kemp, Bruce E., and Power, David A.
- Subjects
ISCHEMIA ,PHOSPHORYLATION ,CORONARY disease ,PROTEIN kinases ,HYPOGLYCEMIC agents ,ADENOSINE triphosphate - Abstract
A fundamental aspect of acute renal ischemia is energy depletion, manifest as a falling level of ATP that is associated with a simultaneous rise in AMP. The energy sensor AMP-activated protein kinase (AMPK) is activated by a rising AMP-to-ATP ratio, but its role in acute renal ischemia is unknown. AMPK is activated in the ischemic heart and is reported to phosphorylate both endothelial nitric oxide synthase (eNOS) and acetyl-CoA carboxylase. To study activation of AMPK in acute renal ischemia, the renal pedicle of anesthetized Sprague-Dawley rats was cross-clamped for increasing time intervals. AMPK was strongly activated within 1 mm and remained so after 30 mm. However, despite the robust activation of AMPK, acute renal ischemia did not increase phosphorylation of the AMPK phosphorylation sites eNOS-Ser
1177 or acetyl-CoA carboxylase-Ser79 . Activation of AMPK in bovine aortic endothelial cells by the ATP-depleting agent antimycin A and the antidiabetic drug phenformin also did not increase phosphorylation of eNOS-Ser1177 , confirming that AMPK activation and phosphorylation of eNOS are dissociated in some situations. Immunoprecipitation studies demonstrated that the dissociation between AMPK activation and phosphorylation of eNOS-Ser1177 was not due to changes in the physical associations between AMPK, eNOS, or heat shock protein 90. In conclusion, acute renal ischemia rapidly activates the energy sensor AMPK, which is known to maintain ATP reserves during energy stress. The substrates it phosphorylates, however, are different from those in other organs such as the heart. [ABSTRACT FROM AUTHOR]- Published
- 2005
- Full Text
- View/download PDF
41. Regulation of the energy sensor AMP-activated protein kinase in the kidney by dietary salt intake and osmolality.
- Author
-
Fraser, Scott, Mount, Peter, Hill, Rebecca, Levidiotis, Vicki, Katsis, Frosa, Stapleton, David, Kemp, Bruce E., and Power, David A.
- Subjects
PROTEIN kinases ,ADENOSINE monophosphate ,KIDNEYS ,LABORATORY rats ,SALT-free diet ,ENERGY metabolism ,WESTERN immunoblotting - Abstract
The AMP-activated protein kinase (AMPK) is a key controller of cellular energy metabolism. We studied its expression and regulation by salt handling in the kidney. Immunoprecipitation and Western blots of protein lysates from whole rat kidney using subunit-specific antibodies showed that the αl-catalytic subunit is expressed in the kidney, associated with the β
2 - and either γ1- or γ2 -subunits. Activated AMPK, detected by immunohistochemical staining for phospho-Thr172 AMPK (pThr172 ), was expressed on the apical surface of the cortical thick ascending limb of the loop of Henle, including the macula densa, and some parts of the distal convoluted tubule. Activated AMPK was also expressed on the basolateral surface of the cortical and medullary collecting ducts as well as some portions of the distal convoluted tubules. AMPK activity was increased by 25% in animals receiving a high-salt diet, and this was confirmed by Western blotting for pThr172 Low-salt diets were associated with reduced levels of the α-subunit of AMPK, which was highly phosphorylated on Thr172 . Surprisingly, both low- and high- salt media transiently activated AMPK in the macula densa cell line MMDD1, an effect due to changes in osmolality, rather than Na+ or C1- concentration. This study, therefore, demonstrates regulation of AMPK by both a high- and a low-salt intake in vivo and suggests a role for the kinase in the response to changes in osmolality within the kidney. [ABSTRACT FROM AUTHOR]- Published
- 2005
- Full Text
- View/download PDF
42. Results from part A of the multi-center, double-blind, randomized, placebo-controlled NefIgArd trial, which evaluated targeted-release formulation of budesonide for the treatment of primary immunoglobulin A nephropathy
- Author
-
Jonathan Barratt, Richard Lafayette, Jens Kristensen, Andrew Stone, Daniel Cattran, Jürgen Floege, Vladimir Tesar, Hernán Trimarchi, Hong Zhang, Necmi Eren, Alexander Paliege, Brad H. Rovin, Guillermo Fragale, Alejandra Karl, Patricia Losisolo, Ivan Gonzalez Hoyos, Mauro Guillermo Lampo, Matias Monkowski, Jorge De La Fuente, Magdalena Alvarez, Daniela Stoppa, Carlos Chiurchiu, Pablo Antonio Novoa, Marcelo Orias, Maria Belen Barron, Ana Giotto, Mariano Arriola, Evelin Cassini, Rafael Maldonado, Maria Paula Dionisi, Jessica Ryan, Nigel Toussaint, Grant Luxton, Chen Au Peh, Vicki Levidiotis, Ross Francis, Richard Phoon, Elena Fedosiuk, Dmitry Toropilov, Ruslan Yakubtsevich, Elena Mikhailova, Christophe Bovy, Nathalie Demoulin, Jean-Michel Hougardy, Bart Maes, Marijn Speeckaert, Louis-Philippe Laurin, Sean Barbour, Melanie Masse, Michelle Hladunewich, Heather Reich, Serge Cournoyer, Karthik Tennankore, Jicheng Lv, Zhangsuo Liu, Caili Wang, Shaomei Li, Qun Luo, Zhaohui Ni, Tiekun Yan, Ping Fu, Hong Cheng, Bicheng Liu, Wanhong Lu, Jianqin Wang, Qinkai Chen, DeGuang Wang, Zuying Xiong, Menghua Chen, Yan Xu, Jiali Wei, Pearl Pai, Lianhua Chen, Jitka Rehorova, Dita Maixnerova, Roman Safranek, Ivan Rychlik, Miroslav Hruby, Satu Makela, Kati Vaaraniemi, Fernanda Ortiz, Eric Alamartine, Maite Daroux, Claire Cartery, Francois Vrtovsnik, Jean-Emmanuel Serre, Eleni Stamellou, Volker Vielhauer, Christian Hugo, Klemens Budde, Britta Otte, Martin Nitschke, Evangelia Ntounousi, Ioannis Boletis, Aikaterini Papagianni, Dimitrios Goumenos, Konstantinos Stylianou, Synodi Zermpala, Ciro Esposito, Mario Gennaro Cozzolino, Sara Maria Viganò, Loreto Gesualdo, Michal Nowicki, Tomasz Stompor, Ilona Kurnatowska, Sung Gyun Kim, Yong-Lim Kim, Ki-Ryang Na, Dong Ki Kim, Su-Hyun Kim, Luis Quintana Porras, Eva Rodriguez Garcia, Irene Agraz Pamplona, Alfons Segarra, Marian Goicoechea, Bengt Fellstrom, Sigrid Lundberg, Peter Hemmingsson, Gregor Guron, Anna Sandell, Cheng-Hsu Chen, Bulent Tokgoz, Soner Duman, Mehmet Riza Altiparmak, Metin Ergul, Peter Maxwell, Patrick Mark, Kieran McCafferty, Arif Khwaja, Chee Kay Cheung, Matthew Hall, Albert Power, Durga Kanigicherla, Richard Baker, Jim Moriarty, Amr Mohamed, Joseph Aiello, Pietro Canetta, Isabelle Ayoub, Derrick Robinson, Surabhi Thakar, Amy Mottl, Isaac Sachmechi, Bernard Fischbach, Harmeet Singh, Jeffrey Mulhern, Fahmeedah Kamal, Douglas Linfert, Dana Rizk, Shikha Wadhwani, Menaka Sarav, Kirk Campbell, Gaia Coppock, Randy Luciano, John Sedor, Rupali Avasare, Wai Lang Lau, Zermpala, Synodi, Esposito, Ciro, Cozzolino, Mario Gennaro, Viganò, Sara Maria, Gesualdo, Loreto, Nowicki, Michal, Stompor, Tomasz, Kurnatowska, Ilona, Kim, Sung Gyun, Kim, Yong-Lim, Na, Ki-Ryang, Kim, Dong Ki, Kim, Su-Hyun, Porras, Luis Quintana, Garcia, Eva Rodriguez, Pamplona, Irene Agraz, Segarra, Alfons, Goicoechea, Marian, Fellstrom, Bengt, Lundberg, Sigrid, Hemmingsson, Peter, Guron, Gregor, Sandell, Anna, Chen, Cheng-Hsu, Tokgoz, Bulent, Duman, Soner, Altiparmak, Mehmet Riza, Ergul, Metin, Maxwell, Peter, Mark, Patrick, Fragale, Guillermo, McCafferty, Kieran, Khwaja, Arif, Cheung, Chee Kay, Hall, Matthew, Power, Albert, Kanigicherla, Durga, Baker, Richard, Moriarty, Jim, Mohamed, Amr, Aiello, Joseph, Karl, Alejandra, Canetta, Pietro, Ayoub, Isabelle, Robinson, Derrick, Thakar, Surabhi, Mottl, Amy, Sachmechi, Isaac, Fischbach, Bernard, Singh, Harmeet, Mulhern, Jeffrey, Kamal, Fahmeedah, Losisolo, Patricia, Linfert, Douglas, Rizk, Dana, Wadhwani, Shikha, Sarav, Menaka, Campbell, Kirk, Coppock, Gaia, Luciano, Randy, Sedor, John, Avasare, Rupali, Lau, Wai Lang, Trimarchi, Hernán, Hoyos, Ivan Gonzalez, Lampo, Mauro Guillermo, Monkowski, Matias, De La Fuente, Jorge, Alvarez, Magdalena, Stoppa, Daniela, Chiurchiu, Carlos, Novoa, Pablo Antonio, Orias, Marcelo, Barron, Maria Belen, Giotto, Ana, Arriola, Mariano, Cassini, Evelin, Maldonado, Rafael, Dionisi, Maria Paula, Ryan, Jessica, Toussaint, Nigel, Luxton, Grant, Peh, Chen Au, Levidiotis, Vicki, Francis, Ross, Phoon, Richard, Fedosiuk, Elena, Toropilov, Dmitry, Yakubtsevich, Ruslan, Mikhailova, Elena, Bovy, Christophe, Demoulin, Nathalie, Hougardy, Jean-Michel, Maes, Bart, Speeckaert, Marijn, Laurin, Louis-Philippe, Barbour, Sean, Masse, Melanie, Hladunewich, Michelle, Reich, Heather, Cournoyer, Serge, Tennankore, Karthik, Lv, Jicheng, Liu, Zhangsuo, Wang, Caili, Li, Shaomei, Luo, Qun, Ni, Zhaohui, Yan, Tiekun, Fu, Ping, Cheng, Hong, Liu, Bicheng, Lu, Wanhong, Wang, Jianqin, Chen, Qinkai, Wang, DeGuang, Xiong, Zuying, Chen, Menghua, Xu, Yan, Wei, Jiali, Pai, Pearl, Chen, Lianhua, Rehorova, Jitka, Maixnerova, Dita, Safranek, Roman, Rychlik, Ivan, Hruby, Miroslav, Makela, Satu, Vaaraniemi, Kati, Ortiz, Fernanda, Alamartine, Eric, Daroux, Maite, Cartery, Claire, Vrtovsnik, Francois, Serre, Jean-Emmanuel, Stamellou, Eleni, Vielhauer, Volker, Hugo, Christian, Budde, Klemens, Otte, Britta, Nitschke, Martin, Ntounousi, Evangelia, Boletis, Ioannis, Papagianni, Aikaterini, Goumenos, Dimitrios, Stylianou, Konstantinos, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, and UCL - (SLuc) Service de néphrologie
- Subjects
gut-associated lymphoid tissue ,glucocorticoids ,Nephrology ,glomerular disease ,IgA nephropathy - Abstract
Kidney international 103(2), 391-402 (2022). doi:10.1016/j.kint.2022.09.017, Published by Elsevier, New York, NY
- Published
- 2022
43. Dentritic cell derived IL-18 production is inhibited by rapamycin and sanglifehrin A, but not cyclosporine A.
- Author
-
Hungta Ko, Hambly, Brett D., Ens, Josette M., Levidiotis, Vicki, Wyburn, Kate, Hulling Wu, Chadban, Steve J., and Yin, Jian L.
- Subjects
- *
GROWTH factors , *IMMUNOSUPPRESSIVE agents , *KIDNEY diseases , *INTERLEUKINS , *CYTOKINES , *HOMOGRAFTS , *T cells - Abstract
Interleukin-18 (IL-18), a product of dendritic cells (DC), is a pro-inflammatory cytokine involved in the pathogenesis of allograft rejection, vascular disease, arthritis and diabetes. Rapamycin (Rapa) is an immunosuppressant that inhibits T cell mTOR kinase activation. In contrast, Sanglifehrin A (SFA), is a cyclophilin-binding immunosuppressant that does not act on calcineurin phosphatases but appears to inhibit IL-2-dependent T cell proliferation. Rapa and SFA exert some immunosuppressive effects on DC by inhibiting IL-12 production, although their effects on DC have not been investigated as comprehensively as those on T cells. We aimed to determine the impact of these drugs on DC IL-18 synthesis in vivo and in vitro. We found in vivo that LPS-stimulated OX62+ DC produced significantly more IL-18 mRNA, compared to OX62+ DC depleted splenocytes (p < 0.01) and non-LPS-stimulated OX62+ DC (p < 0.01). OX62+CD4+ and OX62+CD4- cells produced similar amounts of IL-18 mRNA. Rapa and SFA, but not CsA, significantly inhibited IL-18 production from OX62+ DC in vitro, in a dose-dependent manner (p < 0.05). In vivo IL-18 production was also inhibited by Rapa and SFA in splenic OX62+ DC (p < 0.01). Finally, inhibition of IL-18 production by Rapa and SFA was independent of the FK506 or cyclophilin pathways, respectively. In conclusion, Rapa and SFA, but not CsA, block IL-18 production and this novel Rapa blockade effect on IL-18 may contribute to the ability of Rapa to inhibit chronic allograft nephropathy and restenosis. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
44. Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser1177.
- Author
-
Mount, Peter F., Hill, Rebecca E., Fraser, Scott A., Levidiotis, Vicki, Katsis, Frosa, Kemp, Bruce E., and Power, David A.
- Subjects
- *
ISCHEMIA , *PHOSPHORYLATION , *CORONARY disease , *PROTEIN kinases , *HYPOGLYCEMIC agents , *ADENOSINE triphosphate - Abstract
A fundamental aspect of acute renal ischemia is energy depletion, manifest as a falling level of ATP that is associated with a simultaneous rise in AMP. The energy sensor AMP-activated protein kinase (AMPK) is activated by a rising AMP-to-ATP ratio, but its role in acute renal ischemia is unknown. AMPK is activated in the ischemic heart and is reported to phosphorylate both endothelial nitric oxide synthase (eNOS) and acetyl-CoA carboxylase. To study activation of AMPK in acute renal ischemia, the renal pedicle of anesthetized Sprague-Dawley rats was cross-clamped for increasing time intervals. AMPK was strongly activated within 1 mm and remained so after 30 mm. However, despite the robust activation of AMPK, acute renal ischemia did not increase phosphorylation of the AMPK phosphorylation sites eNOS-Ser1177 or acetyl-CoA carboxylase-Ser79. Activation of AMPK in bovine aortic endothelial cells by the ATP-depleting agent antimycin A and the antidiabetic drug phenformin also did not increase phosphorylation of eNOS-Ser1177, confirming that AMPK activation and phosphorylation of eNOS are dissociated in some situations. Immunoprecipitation studies demonstrated that the dissociation between AMPK activation and phosphorylation of eNOS-Ser1177 was not due to changes in the physical associations between AMPK, eNOS, or heat shock protein 90. In conclusion, acute renal ischemia rapidly activates the energy sensor AMPK, which is known to maintain ATP reserves during energy stress. The substrates it phosphorylates, however, are different from those in other organs such as the heart. [ABSTRACT FROM AUTHOR]
- Published
- 2005
- Full Text
- View/download PDF
45. Reduction in renal ACE2 expression in subtotal nephrectomy in rats is ameliorated with ACE inhibition.
- Author
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Velkoska E, Dean RG, Burchill L, Levidiotis V, and Burrell LM
- Subjects
- Angiotensin-Converting Enzyme 2, Animals, Female, Gene Expression, Hypertension drug therapy, Hypertension metabolism, Kidney drug effects, Kidney injuries, Nephrectomy, Polyuria drug therapy, Polyuria metabolism, Proteinuria drug therapy, Proteinuria metabolism, Proto-Oncogene Mas, Proto-Oncogene Proteins genetics, Proto-Oncogene Proteins metabolism, Random Allocation, Rats, Rats, Sprague-Dawley, Receptors, G-Protein-Coupled genetics, Receptors, G-Protein-Coupled metabolism, Angiotensin-Converting Enzyme Inhibitors pharmacology, Kidney metabolism, Peptidyl-Dipeptidase A metabolism, Ramipril pharmacology
- Abstract
Alterations within the RAS (renin-angiotensin system) are pivotal for the development of renal disease. ACE2 (angiotensin-converting enzyme 2) is expressed in the kidney and converts the vasoconstrictor AngII (angiotensin II) into Ang-(1-7), a peptide with vasodilatory and anti-fibrotic actions. Although the expression of ACE2 in the diabetic kidney has been well studied, little is known about its expression in non-diabetic renal disease. In the present study, we assessed ACE2 in rats with acute kidney injury induced by STNx (subtotal nephrectomy). STNx and Control rats received vehicle or ramipril (1 mg. kg (-1) of body weight . day (-1), and renal ACE, ACE2 and mas receptor gene and protein expression were measured 10 days later. STNx rats were characterized by polyuria, proteinuria, hypertension and elevated plasma ACE2 activity (all P<0.01) and plasma Ang-(1-7) (P<0.05) compared with Control rats. There was increased cortical ACE binding and medullary mas receptor expression (P<0.05), but reduced cortical and medullary ACE2 activity in the remnant kidney (P<0.05 and P<0.001 respectively) compared with Control rats. In STNx rats, ramipril reduced blood pressure (P<0.01), polyuria (P<0.05)and plasma ACE2 (P<0.01), increased plasma Ang-(1-7) (P<0.001), and inhibited renal ACE(P<0.001). Ramipril increased both cortical and medullary ACE2 activity (P<0.01), but reduced medullary mas receptor expression (P<0.05). In conclusion, our results show that ACE2 activity is reduced in kidney injury and that ACE inhibition produced beneficial effects in association with increased renal ACE2 activity. As ACE2 both degrades AngII and generates the vasodilator Ang-(1-7), a decrease in renal ACE2 activity, as observed in the present study, has the potential to contribute to the progression of kidney disease.
- Published
- 2010
- Full Text
- View/download PDF
46. Live kidney donors - assessment and follow up.
- Author
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Levidiotis V
- Subjects
- Australia, Biomarkers blood, Biomarkers urine, Counseling, Humans, Patient Satisfaction, Physician's Role, Physicians, Family, Postoperative Care psychology, Postoperative Complications blood, Postoperative Complications diagnosis, Postoperative Complications urine, Practice Guidelines as Topic, Preoperative Care psychology, Donor Selection, Kidney Transplantation methods, Living Donors, Nephrectomy adverse effects, Postoperative Care methods, Preoperative Care methods
- Abstract
Background: Live kidney donation has increased steadily over the past decade, both in Australia and internationally. In some centres more than 50% of patients receiving a kidney transplant do so from a living related or unrelated donor. Live nondirected or altruistic donation has become more popular, as have paired exchange programs. General practitioners may be involved in pre-donation counselling and the assessment and follow up of otherwise healthy kidney donors., Objective: This overview outlines the clinical pathway and considerations required pre- and post-live kidney donation and highlights some of the uncertainties of donor nephrectomy., Discussion: Live donation requires comprehensive physical, psychological and immunological assessment of the donor-recipient pair. Assessment requires an integrated approach that incorporates the skills of a number of clinicians and allied health practitioners. General practitioners have a crucial role in the counselling, assessment and follow up of live kidney donors.
- Published
- 2009
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