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4. Embolization of percutaneous left atrial appendage closure devices: Timing, management and clinical outcomes

Author

Eppinger, Sophie, Piayda, Kerstin, Galea, Roberto, Sandri, Marcus, Maarse, Moniek, Güner, Ahmet, Karabay, Can Y., Pershad, Ashish, Ding, Wern Y., Aminian, Adel, Akin, Ibrahim, Davtyan, Karapet V., Chugunov, Ivan A., Marijon, Eloi, Rosseel, Liesbeth, Schmidt, Thomas Robert, Amabile, Nicolas, Korsholm, Kasper, Lund, Juha, Guerios, Enio, Amat-Santos, Ignacio J., Boccuzzi, Giacomo, Ellis, Christopher R., Sabbag, Avi, Ebelt, Henning, Clapp, Brian, Assa, Hana Vaknin, Levi, Amos, Ledwoch, Jakob, Lehmann, Sonja, Lee, Oh-Hyun, Mark, George, Schell, Wendy, della Rocca, Domenico G., Natale, Andrea, de Backer, Ole, Kefer, Joelle, Esteban, Pablo P., Abelson, Mark, Ram, Pradhum, Moceri, Pamela, Galache Osuna, Jose G., Alvarez, Xavier Millán, Cruz-Gonzalez, Ignacio, de Potter, Tom, Ghassan, Moubarak, Osadchiy, Andrey, Chen, Weita, Goyal, Sandeep K., Giannini, Francesco, Rivero-Ayerza, Máximo, Afzal, Shazia, Jung, Christian, Skurk, Carsten, Langel, Martin, Spence, Mark, Merkulov, Evgeny, Lempereur, Mathieu, Shin, Seung Y., Mesnier, Jules, McKinney, Heather L., Schuler, Brian T., Armero, Sebastien, Gheorghe, Livia, Ancona, Marco B.M., Santos, Lino, Mansourati, Jacques, Nombela-Franco, Luis, Nappi, Francesco, Kühne, Michael, Gaspardone, Achille, van der Pals, Jesper, Montorfano, Matteo, Fernández-Armenta, Juan, Harvey, James E., Rodés-Cabau, Josep, Klein, Norbert, Sabir, Sajjad A., Kim, Jung-Sun, Cook, Stephane, Kornowski, Ran, Saraste, Antti, Nielsen-Kudsk, Jens E., Gupta, Dhiraj, Boersma, Lucas, Räber, Lorenz, Sievert, Kolja, Sievert, Horst, and Bertog, Stefan

Published
2024
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5. The Impact of Cerebral Embolic Protection Devices on Characteristics and Outcomes of Stroke Complicating TAVR

Author

Levi, Amos, Linder, Matthias, Seiffert, Moritz, Witberg, Guy, Pilgrim, Thomas, Tomii, Daijiro, Barkan, Yeela Tamlor, Van Mieghem, Nicolas M., Adrichem, Rik, Codner, Pablo, Hildick-Smith, David, Arunothayaraj, Sandeep, Perl, Leor, Finkelstein, Ariel, Loewenstein, Itamar, De Backer, Ole, Barnea, Rani, Tarantini, Giuseppe, Fovino, Luca Nai, Vaknin-Assa, Hana, Mylotte, Darren, Wagener, Max, Webb, John G., Akodad, Mariama, Colombo, Antonio, Mangieri, Antonio, Latib, Azeem, Kargoli, Faraj, Giannini, Francesco, Ielasi, Alfonso, Søndergaard, Lars, Aviram, Itay, Lerman, Tsahi T., Kheifets, Mark, Auriel, Eitan, and Kornowski, Ran

Published
2024
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8. Reply

Author

Levi, Amos, primary, Witberg, Guy, additional, and Kornowski, Ran, additional

Published
2024
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13. Modifiable Risk Factors and Residual Risk Following Coronary Revascularization: Insights From a Regionalized Dedicated Follow-Up Clinic

Author

Simard, Trevor, Jung, Richard G., Di Santo, Pietro, Harnett, David T., Abdel-Razek, Omar, Ramirez, F. Daniel, Motazedian, Pouya, Parlow, Simon, Labinaz, Alisha, Moreland, Robert, Marbach, Jeffrey, Poulin, Anthony, Levi, Amos, Majeed, Kamran, Boland, Paul, Couture, Etienne, Sarathy, Kiran, Promislow, Steven, Russo, Juan J., Chong, Aun Yeong, So, Derek, Froeschl, Michael, Dick, Alexander, Labinaz, Marino, Le May, Michel, Holmes, David R., Jr., and Hibbert, Benjamin

Published
2021
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14. Outcomes and predictors of left ventricle recovery in patients with severe left ventricular dysfunction undergoing transcatheter aortic valve implantation

Author

Witberg, Guy, primary, Levi, Amos, additional, Talmor-Barkan, Yeela, additional, Barbanti, Marco, additional, Valvo, Roberto, additional, Costa, Giuliano, additional, Frittitta, Valentina, additional, de Backer, Ole, additional, Willemen, Yannick, additional, van Der Dorpel, Mark, additional, Mon, Matias, additional, Sugiura, Atsushi, additional, Sudo, Mitsumasa, additional, Masiero, Giulia, additional, Pancaldi, Edoardo, additional, Arzamendi, Dabit, additional, Santos-Martinez, Sandra, additional, Baz, Jose A., additional, Steblovnik, Klemen, additional, Mauri, Victor, additional, Adam, Matti, additional, Wienemann, Hendrik, additional, Zahler, David, additional, Hein, Manuel, additional, Ruile, Philipp, additional, Aodha, Brídóg Nic, additional, Grasso, Carmelo, additional, Branca, Luca, additional, Estévez-Loureiro, Rodrigo, additional, Amat-Santos, Ignacio J., additional, Mylotte, Darren, additional, Bunc, Matjaz, additional, Tarantini, Giuseppe, additional, Nombela-Franco, Luis, additional, Sondergaard, Lars, additional, Van Mieghem, Nicolas M., additional, Finkelstein, Ariel, additional, and Kornowski, Ran, additional

Published
2024
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16. Transcatheter Mitral Valve Repair in Cardiogenic Shock and Mitral Regurgitation: A Patient-Level, Multicenter Analysis

Author

Jung, Richard G., Simard, Trevor, Kovach, Christopher, Flint, Kelsey, Don, Creighton, Di Santo, Pietro, Adamo, Marianna, Branca, Luca, Valentini, Francesca, Benito-González, Tomás, Fernández-Vázquez, Felipe, Estévez-Loureiro, Rodrigo, Berardini, Alessandra, Conti, Nicolina, Rapezzi, Claudio, Biagini, Elena, Parlow, Simon, Shorr, Risa, Levi, Amos, Manovel, Ana, Cardenal-Piris, Rosa, Diaz Fernandez, Jose, Shuvy, Mony, Haberman, Dan, Sala, Alessandra, Alkhouli, Mohamad A., Marini, Claudia, Bargagna, Marta, Schiavi, Davide, Denti, Paolo, Markovic, Sinisa, Buzzatti, Nicola, Chan, Vincent, Hynes, Mark, Mesana, Thierry, Labinaz, Marino, Pappalardo, Federico, Taramasso, Maurizio, and Hibbert, Benjamin

Published
2021
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20. The real-world safety of sacubitril / valsartan among older adults (≥75): A pharmacovigilance study from the FDA data

Author

Lerman, Tsahi T., primary, Greenberg, Noam, additional, Fishman, Boris, additional, Goldman, Adam, additional, Talmor-Barkan, Yeela, additional, Menachem, Bauer, additional, Goldberg, Idan, additional, Goldberg, Elad, additional, Kornowski, Ran, additional, Krause, Ilan, additional, Levi, Amos, additional, and Cohen, Eytan, additional

Published
2023
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24. Predictors of 1-Year Mortality After Transcatheter Aortic Valve Implantation in Patients With and Without Advanced Chronic Kidney Disease

Author

Levi, Amos, Codner, Pablo, Masalha, Amer, Gargiulo, Giuseppe, Praz, Fabien, Hayashida, Kentaro, Watanabe, Yusuke, Mylotte, Darren, Debry, Nicolas, Barbanti, Marco, Lefèvre, Thierry, Modine, Thomas, Bosmans, Johan, Windecker, Stephan, Barbash, Israel, Sinning, Jan-Malte, Nickenig, Georg, Barsheshet, Alon, and Kornowski, Ran

Published
2017
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25. Acute Reduction in Left Ventricular Function Following Transcatheter Mitral Edge‐to‐Edge Repair

Author

Perl, Leor, primary, Kheifets, Mark, additional, Guido, Ascione, additional, Agricola, Eustachio, additional, Denti, Paolo, additional, Wild, Mirjam Gauri, additional, Praz, Fabien, additional, Rubbio, Antonio Popolo, additional, Bedogni, Francesco, additional, De Marco, Federico, additional, Beeri, Ronen, additional, Shuvy, Mony, additional, Melillo, Francesco, additional, Montorfano, Matteo, additional, Freixa, Xavier, additional, de la Fuente Mancera, Juan Carlos, additional, Giordano, Arturo, additional, Finizio, Filippo, additional, Van Mieghem, Nicolas M., additional, Ooms, J. F. W., additional, Fam, Neil, additional, O'Connor, Cormac, additional, Toggweiler, Stefan, additional, Levi, Amos, additional, Shapira, Yaron, additional, Schwartzenberg, Shmuel, additional, Pidello, Stefano, additional, D'Ascenzo, Fabrizio, additional, Angelini, Filippo, additional, Haberman, Dan, additional, Crimi, Gabriele, additional, Porto, Italo, additional, Cozzi, Ottavia, additional, Giannini, Francesco, additional, Tarantini, Giuseppe, additional, Maisano, Francesco, additional, Kornowski, Ran, additional, Perl, Leor, additional, Corcione, Nicola, additional, O’Connor, Cormac, additional, D’Ascenzo, Fabrizio, additional, Mangieri, Antonio, additional, Regazzoli, Damiano, additional, Cimaglia, Paolo, additional, Flamigni, Filippo, additional, and Masiero, Giulia, additional

Published
2023
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30. Transcatheter Interventions for Atrioventricular Dysfunction in Patients with Adult Congenital Heart Disease:An International Case Series

Author

Schamroth Pravda, Nili, Vaknin Assa, Hana, Sondergaard, Lars, Bajoras, Vilhelmas, Sievert, Horst, Piayda, Kerstin, Levi, Amos, Witberg, Guy, Shapira, Yaron, Hamdan, Ashraf, Perl, Leor, Vig, Shahar, Blieden, Leonard, Kornowski, Ran, Hirsch, Rafael, Codner, Pablo, Schamroth Pravda, Nili, Vaknin Assa, Hana, Sondergaard, Lars, Bajoras, Vilhelmas, Sievert, Horst, Piayda, Kerstin, Levi, Amos, Witberg, Guy, Shapira, Yaron, Hamdan, Ashraf, Perl, Leor, Vig, Shahar, Blieden, Leonard, Kornowski, Ran, Hirsch, Rafael, and Codner, Pablo

Abstract

Introduction: A substantial proportion of patients with adult congenital heart disease (ACHD) suffer from worsening valvular dysfunction in adulthood. Transcatheter valve interventions can offer a therapeutic alternative to surgery for those at high surgical risk. There is emerging but limited data on transcatheter interventions for atrioventricular (AV) valve dysfunction in patients with ACHD. Methods: We compiled an international collaborative multi-center registry focusing on adult patients with congenital heart disease undergoing transcatheter AV valve interventions (repair or replacement). Included were patients from three international centers who underwent procedures between 2016 and 2022. Demographic, clinical, and procedural data were compiled. Results: Nine patients with ACHD underwent AV valve interventions. The median age was 48 years (IQR (37; 56), 55% women). At baseline, seven patients (78%) were in NYHA functional class III and two (22%) were in NYHA functional class II. The diagnosis of ACHD varied. Three valve interventions were performed on the subpulmonary AV valve and six on the systemic AV valve. The primary valvular pathology was regurgitation (six patients, 78%). Five procedures were valve-in-valve interventions, and four procedures were transcatheter edge-to-edge repair procedures. There were no major complications or peri-procedural complications or peri-procedural mortality. One patient developed a suspected non-obstructive thrombus on the valve that was medically treated. One patient did not improve clinically following the procedure and underwent a heart transplant, one patient died 6 months following the procedure due to a cardiovascular implantable electronic device infection. At one year, six patients were in NYHA functional class I, and one patient was in NYHA functional class III. In conclusion, transcatheter AV heart valve interventions are feasible and safe procedures in carefully selected ACHD patients. These procedures can offer, Introduction: A substantial proportion of patients with adult congenital heart disease (ACHD) suffer from worsening valvular dysfunction in adulthood. Transcatheter valve interventions can offer a therapeutic alternative to surgery for those at high surgical risk. There is emerging but limited data on transcatheter interventions for atrioventricular (AV) valve dysfunction in patients with ACHD. Methods: We compiled an international collaborative multi-center registry focusing on adult patients with congenital heart disease undergoing transcatheter AV valve interventions (repair or replacement). Included were patients from three international centers who underwent procedures between 2016 and 2022. Demographic, clinical, and procedural data were compiled. Results: Nine patients with ACHD underwent AV valve interventions. The median age was 48 years (IQR (37; 56), 55% women). At baseline, seven patients (78%) were in NYHA functional class III and two (22%) were in NYHA functional class II. The diagnosis of ACHD varied. Three valve interventions were performed on the subpulmonary AV valve and six on the systemic AV valve. The primary valvular pathology was regurgitation (six patients, 78%). Five procedures were valve-in-valve interventions, and four procedures were transcatheter edge-to-edge repair procedures. There were no major complications or peri-procedural complications or peri-procedural mortality. One patient developed a suspected non-obstructive thrombus on the valve that was medically treated. One patient did not improve clinically following the procedure and underwent a heart transplant, one patient died 6 months following the procedure due to a cardiovascular implantable electronic device infection. At one year, six patients were in NYHA functional class I, and one patient was in NYHA functional class III. In conclusion, transcatheter AV heart valve interventions are feasible and safe procedures in carefully selected ACHD patients. These procedures can of

Published
2023

31. Acute Reduction in Left Ventricular Function Following Transcatheter Mitral Edge-to-Edge Repair

Author

Perl, Leor, Kheifets, Mark, Guido, Ascione, Agricola, Eustachio, Denti, Paolo, Wild, Mirjam Gauri, Praz, Fabien, Rubbio, Antonio Popolo, Bedogni, Francesco, De Marco, Federico, Beeri, Ronen, Shuvy, Mony, Melillo, Francesco, Montorfano, Matteo, Freixa, Xavier, de la Fuente Mancera, Juan Carlos, Giordano, Arturo, Finizio, Filippo, Van Mieghem, Nicolas M., Ooms, J. F.W., Fam, Neil, O’connor, Cormac, Toggweiler, Stefan, Levi, Amos, Shapira, Yaron, Schwartzenberg, Shmuel, Pidello, Stefano, D’ascenzo, Fabrizio, Angelini, Filippo, Haberman, Dan, Crimi, Gabriele, Porto, Italo, Cozzi, Ottavia, Giannini, Francesco, Tarantini, Giuseppe, Maisano, Francesco, Kornowski, Ran, Perl, Leor, Kheifets, Mark, Guido, Ascione, Agricola, Eustachio, Denti, Paolo, Wild, Mirjam Gauri, Praz, Fabien, Rubbio, Antonio Popolo, Bedogni, Francesco, De Marco, Federico, Beeri, Ronen, Shuvy, Mony, Melillo, Francesco, Montorfano, Matteo, Freixa, Xavier, de la Fuente Mancera, Juan Carlos, Giordano, Arturo, Finizio, Filippo, Van Mieghem, Nicolas M., Ooms, J. F.W., Fam, Neil, O’connor, Cormac, Toggweiler, Stefan, Levi, Amos, Shapira, Yaron, Schwartzenberg, Shmuel, Pidello, Stefano, D’ascenzo, Fabrizio, Angelini, Filippo, Haberman, Dan, Crimi, Gabriele, Porto, Italo, Cozzi, Ottavia, Giannini, Francesco, Tarantini, Giuseppe, Maisano, Francesco, and Kornowski, Ran

Abstract

BACKGROUND: Little is known about the impact of transcatheter mitral valve edge-to-edge repair on changes in left ventricular ejection fraction (LVEF) and the effect of an acute reduction in LVEF on prognosis. We aimed to assess changes in LVEF after transcatheter mitral valve edge-to-edge repair for both primary and secondary mitral regurgitation (PMR and SMR, respectively), identify rates and predictors of LVEF reduction, and estimate its impact on prognosis. METHODS AND RESULTS: In this international multicenter registry, patients with both PMR and SMR undergoing transcatheter mitral valve edge-to-edge repair were included. We assessed rates of acute LVEF reduction (LVEFR), defined as an acute relative decrease of >15% in LVEF, its impact on all-cause mortality, major adverse cardiac event (composite end point of all-cause death, mitral valve surgery, and residual mitral regurgitation grade ≥2), and LVEF at 12 months, as well as predictors for LVEFR. Of 2534 patients included (727 with PMR, and 1807 with SMR), 469 (18.5%) developed LVEFR. Patients with PMR were older (79.0±9.2 versus 71.8±8.9 years; P<0.001) and had higher mean LVEF (54.8±14.0% versus 32.7±10.4%; P<0.001) at baseline. After 6 to 12 months (median, 9.9 months; interquartile range, 7.8–11.9 months), LVEF was significantly lower in patients with PMR (53.0% versus 56.0%; P<0.001) but not in patients with SMR. The 1-year mortality was higher in patients with PMR with LVEFR (16.9% versus 9.7%; P<0.001) but not in those with SMR (P=0.236). LVEF at baseline (odds ratio, 1.03 [95% CI, 1.01– 1.05]; P=0.002) was predictive of LVEFR for patients with PMR, but not those with SMR (P=0.092). CONCLUSIONS: Reduction in LVEF is not uncommon after transcatheter mitral valve edge-to-edge repair and is correlated with worsened prognosis in patients with PMR but not patients with SMR. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05311163.

Published
2023

34. Transcatheter Interventions for Atrioventricular Dysfunction in Patients with Adult Congenital Heart Disease: An International Case Series

Author

Schamroth Pravda, Nili, primary, Vaknin Assa, Hana, additional, Sondergaard, Lars, additional, Bajoras, Vilhelmas, additional, Sievert, Horst, additional, Piayda, Kerstin, additional, Levi, Amos, additional, Witberg, Guy, additional, Shapira, Yaron, additional, Hamdan, Ashraf, additional, Perl, Leor, additional, Vig, Shahar, additional, Blieden, Leonard, additional, Kornowski, Ran, additional, Hirsch, Rafael, additional, and Codner, Pablo, additional

Published
2023
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37. Outcomes of Transcatheter Edge-to-Edge Repair in Degenerative vs. Functional Mitral Regurgitation

Author

Kheifets, Mark, primary, Angelini, Filippo, additional, D’Ascenzo, Fabrizio, additional, Pidello, Stefano, additional, Engelstein, Haya, additional, Bocchino, Pier Paolo, additional, Boretto, Paolo, additional, Frea, Simone, additional, Levi, Amos, additional, Vaknin-Assa, Hana, additional, Vaturi, Mordehay, additional, Shapira, Yaron, additional, Kornowski, Ran, additional, and Perl, Leor, additional

Published
2022
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39. Management and Outcome of Acute Ischemic Stroke Complicating Transcatheter Aortic Valve Replacement

Author

Levi, Amos, primary, Linder, Matthias, additional, Seiffert, Moritz, additional, Witberg, Guy, additional, Pilgrim, Thomas, additional, Tomii, Daijiro, additional, Talmor-Barkan, Yeela, additional, Van Mieghem, Nicolas M., additional, Adrichem, Rik, additional, Codner, Pablo, additional, Smith, David Hildick, additional, Arunothayaraj, Sandeep, additional, Perl, Leor, additional, Finkelstein, Ariel, additional, Loewenstein, Itamar, additional, Findler, Michael, additional, Søndergaard, Lars, additional, De Backer, Ole, additional, Wang, Christina, additional, Barnea, Rani, additional, Tarantini, Giuseppe, additional, Fovino, Luca Nai, additional, Vaknin-Assa, Hana, additional, Mylotte, Darren, additional, Lunardi, Mattia, additional, Raphaeli, Guy, additional, Webb, John G., additional, Akodad, Mariama, additional, Colombo, Antonio, additional, Mangieri, Antonio, additional, Latib, Azeem, additional, Kargoli, Faraj, additional, Giannini, Francesco, additional, Ielasi, Alfonso, additional, Cockburn, James, additional, Higgen, Focko L., additional, Aviram, Itay, additional, Gitto, Mauro, additional, Hokken, Thijmen W., additional, Auriel, Eitan, additional, and Kornowski, Ran, additional

Published
2022
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40. TCT-100 Temporal Trends in Complex PCI Interventions

Author

Kheifets, Mark, primary, Vons, Shelly, additional, Bental, Tamir, additional, Assa, Hana Vaknin, additional, Greenberg, Gabriel, additional, Samara, Abed, additional, Codner, Pablo, additional, Witberg, Guy, additional, Talmor, Yeela, additional, Perl, Leor, additional, Kornowski, Ran, additional, and Levi, Amos, additional

Published
2022
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41. Coronary Computed Tomography Angiography and Abdominal Aortic Calcification Screening among High-Risk Living Kidney Donors.

Author

Skalsky, Keren, Shiyovich, Arthur, Hochwald, Nir, Levi, Amos, Zreik, Lutof, Tamir, Shlomit, Shafir, Gideon, Briger, Anat, Rahamimov, Ruth, Kornowski, Ran, and Hamdan, Ashraf

Subjects
COMPUTED tomography, CORONARY artery calcification, CORONARY artery stenosis, MEDICAL screening, ANGIOGRAPHY
Abstract

Background: A unique scanning protocol combining coronary computed tomography angiography (CTA) with routine abdominal CTA is being used at the Rabin Medical Center as a method of screening high-risk candidates for living kidney donation. We aim to evaluate the potential impact of coronary CTA on the decision regarding eligibility for kidney donation and its correlation with abdominal aortic calcification (AAC). Methods: CCTA and abdominal CTA results of potential living kidney donors evaluated for donation between September 2020 and November 2021 were retrieved. A retrospective analysis of the abdominal CTA was used to calculate the AAC. Patients' demographic, clinical, and imaging data were collected from the electronic files, as well as the final decision regarding eligibility for donation. Results: A total of 62 potential kidney donors were evaluated for donation using the combined scan. The mean age was 53.8 years, with male predominance (59.7%). Significant coronary artery stenosis (≥70% luminal stenosis) was present in two patients (3.2%), whereas five patients (8%) had moderate stenosis (50–69%). Thirteen patients (21%) were disqualified from donation due to moderate-to-significant coronary artery disease or abdominal atherosclerosis. The correlation between the coronary artery calcium score and the AAC was found to be positive, with a Pearson correlation coefficient of 0.88 (p < 0.001). Conclusions: The use of coronary CTA in the evaluation of potential kidney donors may has a potential impact on the decision regarding eligibility for donation. A high correlation between the coronary artery calcium score and the AAC was found. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Temporal Trends in Complex Percutaneous Coronary Interventions

Author

Kheifets, Mark, primary, Vons, Shelly Abigail, additional, Bental, Tamir, additional, Vaknin-Assa, Hana, additional, Greenberg, Gabriel, additional, Samara, Abed, additional, Codner, Pablo, additional, Wittberg, Guy, additional, Talmor Barkan, Yeela, additional, Perl, Leor, additional, Kornowski, Ran, additional, and Levi, Amos, additional

Published
2022
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43. Management and Outcome of Acute Ischemic Stroke Complicating Transcatheter Aortic Valve Replacement

Author

Levi, Amos, Linder, Matthias, Seiffert, Moritz, Witberg, Guy, Pilgrim, Thomas, Tomii, Daijiro, Talmor-Barkan, Yeela, Van Mieghem, Nicolas M., Adrichem, Rik, Codner, Pablo, Smith, David Hildick, Arunothayaraj, Sandeep, Perl, Leor, Finkelstein, Ariel, Loewenstein, Itamar, Findler, Michael, Søndergaard, Lars, De Backer, Ole, Wang, Christina, Barnea, Rani, Tarantini, Giuseppe, Fovino, Luca Nai, Vaknin-Assa, Hana, Mylotte, Darren, Lunardi, Mattia, Raphaeli, Guy, Webb, John G., Akodad, Mariama, Colombo, Antonio, Mangieri, Antonio, Latib, Azeem, Kargoli, Faraj, Giannini, Francesco, Ielasi, Alfonso, Cockburn, James, Higgen, Focko L., Aviram, Itay, Gitto, Mauro, Hokken, Thijmen W., Auriel, Eitan, Kornowski, Ran, Levi, Amos, Linder, Matthias, Seiffert, Moritz, Witberg, Guy, Pilgrim, Thomas, Tomii, Daijiro, Talmor-Barkan, Yeela, Van Mieghem, Nicolas M., Adrichem, Rik, Codner, Pablo, Smith, David Hildick, Arunothayaraj, Sandeep, Perl, Leor, Finkelstein, Ariel, Loewenstein, Itamar, Findler, Michael, Søndergaard, Lars, De Backer, Ole, Wang, Christina, Barnea, Rani, Tarantini, Giuseppe, Fovino, Luca Nai, Vaknin-Assa, Hana, Mylotte, Darren, Lunardi, Mattia, Raphaeli, Guy, Webb, John G., Akodad, Mariama, Colombo, Antonio, Mangieri, Antonio, Latib, Azeem, Kargoli, Faraj, Giannini, Francesco, Ielasi, Alfonso, Cockburn, James, Higgen, Focko L., Aviram, Itay, Gitto, Mauro, Hokken, Thijmen W., Auriel, Eitan, and Kornowski, Ran

Abstract

Background: Despite advances in transcatheter aortic valve replacement (TAVR), periprocedural acute ischemic stroke remains a concern. Objectives: The aims of this study were to investigate acute ischemic stroke complicating TAVR (AISCT) and to describe the indications and outcomes of interventions to treat AISCT. Methods: An international multicenter registry was established focusing on AISCT within 30 days of TAVR. Stroke severity was assessed using the National Institutes of Health Stroke Scale. Primary outcomes were 1-year all-cause death and neurologic disability status at 90 days according to modified Rankin scale score. Results: Of 16,615 TAVR procedures, 387 patients with AISCT were included (2.3%). Rates of 1-year death were 28.9%, 35.9%, and 77.5% in patients with mild, moderate, and severe stroke, respectively (P < 0.001). Although 348 patients were managed conservatively, 39 patients (10.1%) underwent neurointervention (NI) with either mechanical thrombectomy (n = 26) or thrombolytic therapy (n = 13). In a subanalysis excluding patients with mild stroke, there was no clear 1-year survival benefit for NI compared with conservative management (47.6% vs 41.1%, respectively; P = 0.78). In a logistic regression model controlling for stroke severity, NI was associated with 2.9-fold odds (95% CI: 1.2-7.0; P = 0.016) of independent survival at 90 days. Conclusions: AISCT carries significant morbidity and mortality, which is correlated with stroke severity. The present findings suggest that neurologic disability for patients with moderate or worse stroke could potentially be improved by timely intervention and highlight the importance of collaboration between cardiologists and neurologists to optimize AISCT outcomes.

Published
2022

45. Tricuspid Structural Valve Deterioration Treated with a Transcatheter Valve-in-Valve Implantation: A Single-Center Prospective Registry

Author

Schamroth Pravda, Nili, primary, Vaknin Assa, Hana, additional, Levi, Amos, additional, Witberg, Guy, additional, Shapira, Yaron, additional, Vaturi, Mordechai, additional, Orvin, Katia, additional, Talmor Barkan, Yeela, additional, Hamdan, Ashraf, additional, Mishaev, Raffael, additional, Sharoni, Ram, additional, Perl, Leor, additional, Sagie, Alexander, additional, Kornowski, Ran, additional, and Codner, Pablo, additional

Published
2022
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46. Five-Year Outcomes of Patients With Mitral Structural Valve Deterioration Treated With Transcatheter Valve in Valve Implantation – A Single Center Prospective Registry

Author

Schamroth Pravda, Nili, primary, Mishaev, Raffael, additional, Levi, Amos, additional, Witberg, Guy, additional, Shapira, Yaron, additional, Orvin, Katia, additional, Barkan, Yeela Talmor, additional, Hamdan, Ashraf, additional, Sharoni, Ram, additional, Perl, Leor, additional, Sagie, Alexander, additional, Assa, Hana Vaknin, additional, Kornowski, Ran, additional, and Codner, Pablo, additional

Published
2022
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47. Improved immunogenicity following the third dose of BNT162b2 mRNA vaccine in heart transplant recipients

Author

Shaul, Aviv Avraham, primary, Itzhaki Ben Zadok, Osnat, additional, Ben-Avraham, Binyamin, additional, Yaari, Vicky, additional, Barsheshet, Alon, additional, Levi, Amos, additional, Ben Zvi, Haim, additional, Eliakim Raz, Noa, additional, Abed, Galia, additional, Abuhazira, Miriam, additional, Abu Akel, Mahmood, additional, Mats, Israel, additional, Barac, Yaron D, additional, Aravot, Dan, additional, Kornowski, Ran, additional, and Ben-Gal, Tuvia, additional

Published
2022
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49. Additional file 2 of Preoperative evaluation of pulmonary hypertension in lung transplant candidates: echocardiography versus right heart catheterization

Author

Abu, Tal, Levi, Amos, Hasdai, David, Kramer, Mordechai R., Bental, Tamir, Bdolah-Abram, Tali, Shyovich, Arthur, Samara, Abed, Vaknin-Assa, Hana, Perl, Leor, Rosengarten, Dror, Shapira, Yaron, Kornowski, Ran, and Skalsky, Keren

Abstract

Additional file 2: Baseline characteristics of patients with measurable TR compared to patients with no measurable TR.

Published
2022
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50. Additional file 1 of Preoperative evaluation of pulmonary hypertension in lung transplant candidates: echocardiography versus right heart catheterization

Author

Abu, Tal, Levi, Amos, Hasdai, David, Kramer, Mordechai R., Bental, Tamir, Bdolah-Abram, Tali, Shyovich, Arthur, Samara, Abed, Vaknin-Assa, Hana, Perl, Leor, Rosengarten, Dror, Shapira, Yaron, Kornowski, Ran, and Skalsky, Keren

Subjects
surgical procedures, operative, respiratory system, respiratory tract diseases
Abstract

Additional file 1: Lung transplant etiologies.

Published
2022
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