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1. Improving the process of grinding food products

Author

Pokintelitsa N. I. and Levchenko E. A.

Subjects
дисперсность, процесс измельчения, мощность привода, угол заострения, dispersion, grinding process, drive power, sharpening angle, General Works
Abstract

There are a large number of studies on the grinding of various types of food raw materials, however, today there is no comprehensive approach to justifying the influence of the design and operational parameters of the grinding process on a number of food product quality indicators. It negatively affects the process of improvement and modernization of technological equipment, production technologies and finished quality production. In this regard, the task is set to implement optimal approaches and technological methods for improving the process of grinding food raw materials and equipment in order to reduce the energy intensity and labor intensity of the process. The analysis obtained on the basis of experimental studies has confirmed the assumption of a significant reduction in cutting effort and work when using knives and gratings with sharp sharpening angles of knife edges and openings for meat products with a high content of high-strength connective tissue (elastin and collagen fibers). The development of modernized cutting tools for meat grinders with blunt and sharp angles of sharpening the edges of the holes of the knife gratings and the cutting edges of the knife blades has been proposed. The introduction of cutting tools with an acute sharpening angle (31°) into production compared with conventional tools makes it possible to reduce significantly (40–75 %) the specific load on the grinding process, which leads to a general reduction in the energy consumption of the grinding process by 25–40 %. Using cutting tools for grinding food products contributes to an increase in the dispersion of minced meat by 10–16 %. The development of a set of working bodies can significantly reduce the cutting work of raw material and increase the organoleptic quality indicators of finished culinary products due to the absence of unmilled connective tissue fibers in the minced meat. Indicators of the influence of the number of grindings, sharpening angles of knife blades and sharpening angles of the edges of the holes of the gratings on the specific work of cutting have been established.

Published
2019
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7. Letter of Intent: A New QCD facility at the M2 beam line of the CERN SPS (COMPASS++/AMBER)

Author

Adams, B., Aidala, C. A., Akhunzyanov, R., Alexeev, G. D., Alexeev, M. G., Amoroso, A., Andrieux, V., Anfimov, N. V., Anosov, V., Antoshkin, A., Augsten, K., Augustyniak, W., Azevedo, C. D. R., Azhibekov, A., Badelek, B., Balestra, F., Ball, M., Barth, J., Beck, R., Bedfer, Y., Antequera, J. Berenguer, Bernauer, J. C., Bernhard, J., Bodlak, M., Bordalo, P., Bradamante, F., Bressan, A., Buchele, M., Burtsev, V. E., Chang, W. -C., Chatterjee, C., Chen, X., Chiosso, M., Chumakov, A. G., Chung, S. -U., Cicuttin, A., Correia, P., Crespo, M. L., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Dashyan, N., Denisenko, I., Denisov, O. Yu., Dhara, L., d'Hose, N., Donato, F., Donskov, S. V., Doshita, N., Dreisbach, Ch., Dunnweber, W., Dusaev, R. R., Dziewiecki, M., Dzyuba, A., Efremov, A., Egelhof, P., Elagin, A., Eversheim, P. D., Faessler, M., Fedotova, J., Ferrero, A., Finger, M., Finger Jr., M., Fischer, H., Franco, C., Friedrich, J. M., Frolov, V., Futch, A., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Gevorkyan, S., Ghandilyan, Y., Giarra, J., Gnesi, I., Gorzellik, M., Grasso, A., Gridin, A., Perdekamp, M. Grosse, Grube, B., Gushterski, R. I., Guskov, A., Hahne, D., Hamar, G., von Harrach, D., He, X., Heitz, R., Herrmann, F., Horikawa, N., Hsieh, C. -Y., Huber, S., Inglessi, A., Ilyichev, A., Isataev, T., Ishimoto, S., Ivanov, A., Ivanov, N., Ivanshin, Yu., Iwata, T., Jandek, M., Jary, V., Jen, C. -M., Joosten, R., Joerg, P., Juraskova, K., Kabuss, E., Kabyshev, A., Kaspar, F., Kerbizi, A., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kim, M., Kiselev, O., Kisselev, Yu., Klein, F., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O. M., Koval, A., Kral, Z., Kraemer, M., Krinner, F., Kulinich, Y., Kunne, F., Kurek, K., Kurjata, R. P., Kuterbekov, K., Kuznetsov, I. I., Kveton, A., Levchenko, E. A., Levorato, S., Lian, Y. -S., Liang, Y., Lichtenstadt, J., Lin, P. -J., Liu, K., Liu, M. X., Longo, R., Lorenzon, W., Losekamm, M., Lyubovitskij, V. E., Maev, E., Maggiora, A., Magnon, A., Makarenko, V., Makins, N., Makke, N., Mallot, G. K., Maltsev, A., Mamon, S. A., Marianski, B., Martin, A., Marukyan, H., Marzec, J., Masi, N., Matousek, J., Matsuda, H., Mattson, G., Meshcheryakov, G. V., Meyer, W., Meyer, M., Mikhailov, Yu. V., Mikhasenko, M., Minot, M., Mitrofanov, E., Mitrofanov, N., Miyachi, Y., Moretti, A., Nagaytsev, A., Naim, C., Neyret, D., Nigmatkulov, G., Mkrtchyan, A., Mkrtchyan, H., Novy, J., Nowak, W. -D., Nozzoli, F., Nukazuka, G., Nunes, A. S., Olshevsky, A. G., Orlov, I., Osborn, J. D., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J. -C., Pereira, F., Peshekhonov, D. V., Pesek, M., Peskova, M., Pierre, N., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Poeschl, T., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Raymond, R., Reicherz, G., Riedl, C., Ryabchikov, D. I., Rybnikov, A., Rychter, A., Salac, R., Samoylenko, V. D., Sandacz, A., Sarkar, S., Sarsour, M., Savin, I. A., Sbrizzai, G., Schmieden, H., Seder, E., Selyunin, A., Simon, H., Sinha, L., Sirtl, S., Slunecka, M., Smolik, J., Srnka, A., Steffen, D., Stolarski, M., Subrt, O., Sulc, M., Suzuki, H., Szabelski, A., Sznajder, P., Tasevsky, M., Tchekhovski, V., Tessaro, S., Tessarotto, F., Thiel, A., Tomsa, J., Tosello, F., Tskhay, V., Uhl, S., Vasilishin, B. I., Vassiliev, A., Vauth, A., Veit, B. M., Ventura, B., Veloso, J., Vidon, A., Virius, M., Vorobyev, A., Wagner, M., Wallner, S., Wilfert, M., Xiao, Z., Xu, N., Yang, J., Zaremba, K., Zavada, P., Zavertyaev, M., Zemlyanichkina, E., Zhao, H., Zhao, Y., Zhuravlev, N., Ziembicki, M., and Zuccon, P.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

A New QCD facility at the M2 beam line of the CERN SPS COMPASS++/AMBER, Comment: 91 pages, 51 figures

Published
2018

8. Light isovector resonances in $\pi^- p \to \pi^-\pi^-\pi^+ p$ at 190 GeV/${\it c}$

Author

Aghasyan, M., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anfimov, N. V., Anosov, V., Antoshkin, A., Augsten, K., Augustyniak, W., Austregesilo, A., Azevedo, C. D. R., Badelek, B., Balestra, F., Ball, M., Barth, J., Beck, R., Bedfer, Y., Bernhard, J., Bicker, K., Bielert, E. R., Birsa, R., Bodlak, M., Bordalo, P., Bradamante, F., Bressan, A., Buechele, M., Burtsev, V. E., Chang, W. -C., Chatterjee, C., Chiosso, M., Choi, I., Chumakov, A. G., Chung, S. -U., Cicuttin, A., Crespo, M. L., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Dhara, L., Donskov, S. V., Doshita, N., Dreisbach, Ch., Duennweber, W., Dusaev, R. R., Dziewiecki, M., Efremov, A., Eversheim, P. D., Faessler, M., Ferrero, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Fuchey, E., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giarra, J., Gnesi, I., Gorzellik, M., Grasso, A., Gridin, A., Perdekamp, M. Grosse, Grube, B., Grussenmeyer, T., Guskov, A., Hass, F., Hahne, D., Hamar, G., von Harrach, D., Heitz, R., Herrmann, F., Horikawa, N., d'Hose, N., Hsieh, C. -Y., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jary, V., Joosten, R., Joerg, P., Juraskova, K., Kabuss, E., Kerbizi, A., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O. M., Kral, Z., Kraemer, M., Krinner, F., Kroumchtein, Z. V., Kulinich, Y., Kunne, F., Kurek, K., Kurjata, R. P., Kuznetsov, I. I., Kveton, A., Lednev, A. A., Levchenko, E. A., Levillain, M., Levorato, S., Lian, Y. -S., Lichtenstadt, J., Longo, R., Lyubovitskij, V. E., Maggiora, A., Magnon, A., Makins, N., Makke, N., Mallot, G. K., Mamon, S. A., Marianski, B., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G. V., Meyer, M., Meyer, W., Mikhailov, Yu. V., Mikhasenko, M., Mitrofanov, E., Mitrofanov, N., Miyachi, Y., Moretti, A., Nagaytsev, A., Nerling, F., Neyret, D., Novy, J., Nowak, W. -D., Nukazuka, G., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J. -C., Pereira, F., Pesek, M., Peskova, M., Peshekhonov, D. V., Pierre, N., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Riedl, C., Rogacheva, N. S., Ryabchikov, D. I., Rybnikov, A., Rychter, A., Salac, R., Samoylenko, V. D., Sandacz, A., Santos, C., Sarkar, S., Savin, I. A., Sawada, T., Sbrizzai, G., Schiavon, P., Schluter, T., Schmeing, S., Schmieden, H., Seder, E., Selyunin, A., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Smolik, J., Srnka, A., Steffen, D., Stolarski, M., Subrt, O., Sulc, M., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Tasevsky, M., Tessaro, S., Tessarotto, F., Thiel, A., Tomsa, J., Tosello, F., Tskhay, V., Uhl, S., Vasilishin, B. I., Vauth, A., Veit, B. M., Veloso, J., Vidon, A., Virius, M., Wallner, S., Wilfert, M., ter Wolbeek, J., Zaremba, K., Zavada, P., Zavertyaev, M., Zemlyanichkina, E., and Ziembicki, M.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

We have performed the most comprehensive resonance-model fit of $\pi^-\pi^-\pi^+$ states using the results of our previously published partial-wave analysis (PWA) of a large data set of diffractive-dissociation events from the reaction $\pi^- + p \to \pi^-\pi^-\pi^+ + p_\text{recoil}$ with a 190 GeV/$c$ pion beam. The PWA results, which were obtained in 100 bins of three-pion mass, $0.5 < m_{3\pi} < 2.5$ GeV/$c^2$, and simultaneously in 11 bins of the reduced four-momentum transfer squared, $0.1 < t' < 1.0$ $($GeV$/c)^2$, are subjected to a resonance-model fit using Breit-Wigner amplitudes to simultaneously describe a subset of 14 selected waves using 11 isovector light-meson states with $J^{PC} = 0^{-+}$, $1^{++}$, $2^{++}$, $2^{-+}$, $4^{++}$, and spin-exotic $1^{-+}$ quantum numbers. The model contains the well-known resonances $\pi(1800)$, $a_1(1260)$, $a_2(1320)$, $\pi_2(1670)$, $\pi_2(1880)$, and $a_4(2040)$. In addition, it includes the disputed $\pi_1(1600)$, the excited states $a_1(1640)$, $a_2(1700)$, and $\pi_2(2005)$, as well as the resonancelike $a_1(1420)$. We measure the resonance parameters mass and width of these objects by combining the information from the PWA results obtained in the 11 $t'$ bins. We extract the relative branching fractions of the $\rho(770) \pi$ and $f_2(1270) \pi$ decays of $a_2(1320)$ and $a_4(2040)$, where the former one is measured for the first time. In a novel approach, we extract the $t'$ dependence of the intensity of the resonances and of their phases. The $t'$ dependence of the intensities of most resonances differs distinctly from the $t'$ dependence of the nonresonant components. For the first time, we determine the $t'$ dependence of the phases of the production amplitudes and confirm that the production mechanism of the Pomeron exchange is common to all resonances., Comment: 224 pages, 172 figures

Published
2018
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9. Transverse Extension of Partons in the Proton probed by Deeply Virtual Compton Scattering

Author

Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anfimov, N. V., Anosov, V., Antoshkin, A., Augsten, K., Augustyniak, W., Austregesilo, A., Azevedo, C. D. R., Badelek, B., Balestra, F., Ball, M., Barth, J., Beck, R., Bedfer, Y., Bernhard, J., Bicker, K., Bielert, E. R., Birsa, R., Bodlak, M., Bordalo, P., Bradamante, F., Bressan, A., Buechele, M., Burtin, E., Burtsev, V. E., Chang, W. -C., Chatterjee, C., Chiosso, M., Choi, I., Chumakov, A. G., Chung, S. -U., Cicuttin, A., Crespo, M. L., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Dhara, L., Donskov, S. V., Doshita, N., Dreisbach, Ch., Duennweber, W., Dusaev, R. R., Dziewiecki, M., Efremov, A., Eversheim, P. D., Faessler, M., Ferrero, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Fuchey, E., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giarra, J., Gnesi, I., Gorzellik, M., Grasso, A., Gridin, A., Perdekamp, M. Grosse, Grube, B., Grussenmeyer, T., Guskov, A., Hahne, D., Hamar, G., von Harrach, D., Heitz, R., Herrmann, F., Horikawa, N., d'Hose, N., Hsieh, C. -Y., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jary, V., Joosten, R., Joerg, P., Juraskova, K., Kabuss, E., Kerbizi, A., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O. M., Kral, Z., Kraemer, M., Krinner, F., Kroumchtein, Z. V., Kulinich, Y., Kunne, F., Kurek, K., Kurjata, R. P., Kuznetsov, I. I., Kveton, A., Lednev, A. A., Levchenko, E. A., Levillain, M., Levorato, S., Lian, Y. -S., Lichtenstadt, J., Longo, R., Lyubovitskij, V. E., Maggiora, A., Magnon, A., Makins, N., Makke, N., Mallot, G. K., Mamon, S. A., Marchand, C., Marianski, B., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G. V., Meyer, M., Meyer, W., Mikhailov, Yu. V., Mikhasenko, M., Mitrofanov, E., Mitrofanov, N., Miyachi, Y., Moretti, A., Nagaytsev, A., Nerling, F., Neyret, D., Novy, J., Nowak, W. -D., Nukazuka, G., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J. -C., Pereira, F., Pesaro, G., Pesek, M., Peskova, M., Peshekhonov, D. V., Pierre, N., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Riedl, C., Rogacheva, N. S., Ryabchikov, D. I., Rybnikov, A., Rychter, A., Salac, R., Samoylenko, V. D., Sandacz, A., Santos, C., Sarkar, S., Savin, I. A., Sawada, T., Sbrizzai, G., Schiavon, P., Schmieden, H., Schoennig, K., Seder, E., Selyunin, A., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Smolik, J., Srnka, A., Steffen, D., Stolarski, M., Subrt, O., Sulc, M., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Tasevsky, M., Tessaro, S., Tessarotto, F., Thiel, A., Tomsa, J., Tosello, F., Tskhay, V., Uhl, S., Vasilishin, B. I., Vauth, A., Veit, B. M., Veloso, J., Vidon, A., Virius, M., Wallner, S., Wilfert, M., ter Wolbeek, J., Zaremba, K., Zavada, P., Zavertyaev, M., Zemlyanichkina, E., Zhuravlev, N., and Ziembicki, M.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

We report on the first measurement of exclusive single-photon muoproduction on the proton by COMPASS using 160 GeV/$c$ polarized $\mu^+$ and $\mu^-$ beams of the CERN SPS impinging on a liquid hydrogen target. We determine the dependence of the average of the measured $\mu^+$ and $\mu^-$ cross sections for deeply virtual Compton scattering on the squared four-momentum transfer $t$ from the initial to the final final proton. The slope $B$ of the $t$-dependence is fitted with a single exponential function, which yields $B=(4.3 \ \pm \ 0.6_{\text{stat}}\_{- \ 0.3}^{+ \ 0.1}\big\rvert_{\text{sys}}) (\text{GeV}/c)^{-2}$. This result can be converted into an average transverse extension of partons in the proton, $\sqrt{\langle r_{\perp}^2 \rangle} = (0.58 \ \pm \ 0.04_{\text{stat}}\_{- \ 0.02}^{+ \ 0.01}\big\rvert_{\text{sys}})\text{fm}$. For this measurement, the average virtuality of the photon mediating the interaction is $\langle Q^2 \rangle = 1.8\,(\text{GeV/}c)^2$ and the average value of the Bjorken variable is $\langle x_{\text{Bj}} \rangle = 0.056$., Comment: 13 pages, 5 figures

Published
2018
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10. Longitudinal double-spin asymmetry $A_1^{\rm p}$ and spin-dependent structure function $g_1^{\rm p}$ of the proton at small values of $x$ and $Q^2$

Author

Aghasyan, M., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anfimov, N. V., Anosov, V., Antoshkin, A., Augsten, K., Augustyniak, W., Austregesilo, A., Azevedo, C. D. R., Badelek, B., Balestra, F., Ball, M., Barth, J., Beck, R., Bedfer, Y., Bernhard, J., Bicker, K., Bielert, E. R., Birsa, R., Bodlak, M., Bordalo, P., Bradamante, F., Bressan, A., Buechele, M., Burtsev, V. E., Chang, W. -C., Chatterjee, C., Chiosso, M., Choi, I., Chumakov, A. G., Chung, S. -U., Cicuttin, A., Crespo, M. L., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Dhara, L., Donskov, S. V., Doshita, N., Dreisbach, Ch., Duennweber, W., Dusaev, R. R., Dziewiecki, M., Efremov, A., Eversheim, P. D., Faessler, M., Ferrero, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Fuchey, E., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giarra, J., Giordano, F., Gnesi, I., Gorzellik, M., Grasso, A., Gridin, A., Perdekamp, M. Grosse, Grube, B., Grussenmeyer, T., Guskov, A., Hahne, D., Hamar, G., von Harrach, D., Heinsius, F. H., Heitz, R., Herrmann, F., Horikawa, N., d'Hose, N., Hsieh, C. -Y., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jary, V., Joosten, R., Joerg, P., Kabuss, E., Kerbizi, A., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O. M., Kral, Z., Kraemer, M., Kremser, P., Krinner, F., Kroumchtein, Z. V., Kulinich, Y., Kunne, F., Kurek, K., Kurjata, R. P., Kuznetsov, I. I., Kveton, A., Lednev, A. A., Levchenko, E. A., Levillain, M., Levorato, S., Lian, Y. -S., Lichtenstadt, J., Longo, R., Lyubovitskij, V. E., Maggiora, A., Magnon, A., Makins, N., Makke, N., Mallot, G. K., Mamon, S. A., Marianski, B., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G. V., Meyer, M., Meyer, W., Mikhailov, Yu. V., Mikhasenko, M., Mitrofanov, E., Mitrofanov, N., Miyachi, Y., Moretti, A., Nagaytsev, A., Nerling, F., Neyret, D., Novy, J., Nowak, W. -D., Nukazuka, G., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J. -C., Pereira, F., Pesek, M., Peskova, M., Peshekhonov, D. V., Pierre, N., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Riedl, C., Rogacheva, N. S., Ryabchikov, D. I., Rybnikov, A., Rychter, A., Salac, R., Samoylenko, V. D., Sandacz, A., Santos, C., Sarkar, S., Savin, I. A., Sawada, T., Sbrizzai, G., Schiavon, P., Schmidt, K., Schmieden, H., Schoenning, K., Seder, E., Selyunin, A., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Smolik, J., Srnka, A., Steffen, D., Stolarski, M., Subrt, O., Sulc, M., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Tasevsky, M., Tessaro, S., Tessarotto, F., Thiel, A., Tomsa, J., Tosello, F., Tskhay, V., Uhl, S., Vasilishin, B. I., Vauth, A., Veloso, J., Vidon, A., Virius, M., Wallner, S., Weisrock, T., Wilfert, M., ter Wolbeek, J., Zaremba, K., Zavada, P., Zavertyaev, M., Zemlyanichkina, E., Zhuravlev, N., and Ziembicki, M.

Subjects
High Energy Physics - Experiment
Abstract

We present a precise measurement of the proton longitudinal double-spin asymmetry $A_1^{\rm p}$ and the proton spin-dependent structure function $g_1^{\rm p}$ at photon virtualities $0.006~({\rm GeV}/c)^2

Published
2017
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11. Transverse-momentum-dependent Multiplicities of Charged Hadrons in Muon-Deuteron Deep Inelastic Scattering

Author

Aghasyan, M., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anfimov, N. V., Anosov, V., Antoshkin, A., Augsten, K., Augustyniak, W., Austregesilo, A., Azevedo, C. D. R., Badelek, B., Balestra, F., Ball, M., Barth, J., Beck, R., Bedfer, Y., Bernhard, J., Bicker, K., Bielert, E. R., Birsa, R., Bodlak, M., Bordalo, P., Bradamante, F., Bressan, A., Buechele, M., Burtsev, V. E., Capozza, L., Chang, W. -C., Chatterjee, C., Chiosso, M., Choi, I., Chumakov, A. G., Chung, S. -U., Cicuttin, A., Crespo, M. L., Curiel, Q., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Dhara, L., Donskov, S. V., Doshita, N., Dreisbach, Ch., Duennweber, W., Dusaev, R. R., Dziewiecki, M., Efremov, A., Eversheim, P. D., Faessler, M., Ferrero, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Fuchey, E., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giarra, J., Giordano, F., Gnesi, I., Gorzellik, M., Grasso, A., Gridin, A., Perdekamp, M. Grosse, Grube, B., Grussenmeyer, T., Guskov, A., Hahne, D., Hamar, G., von Harrach, D., Heinsius, F. H., Heitz, R., Herrmann, F., Horikawa, N., d'Hose, N., Hsieh, C. -Y., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jary, V., Joosten, R., Joerg, P., Kabuss, E., Kerbizi, A., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O. M., Kral, Z., Kraemer, M., Kremser, P., Krinner, F., Kroumchtein, Z. V., Kulinich, Y., Kunne, F., Kurek, K., Kurjata, R. P., Kuznetsov, I. I., Kveton, A., Lednev, A. A., Levchenko, E. A., Levillain, M., Levorato, S., Lian, Y. -S., Lichtenstadt, J., Longo, R., Lyubovitskij, V. E., Maggiora, A., Magnon, A., Makins, N., Makke, N., Mallot, G. K., Mamon, S. A., Marianski, B., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G. V., Meyer, M., Meyer, W., Mikhailov, Yu. V., Mikhasenko, M., Mitrofanov, E., Mitrofanov, N., Miyachi, Y., Moretti, A., Nagaytsev, A., Nerling, F., Neyret, D., Novy, J., Nowak, W. -D., Nukazuka, G., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J. -C., Pereira, F., Pesek, M., Peskova, M., Peshekhonov, D. V., Pierre, N., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Riedl, C., Rogacheva, N. S., Ryabchikov, D. I., Rybnikov, A., Rychter, A., Salac, R., Samoylenko, V. D., Sandacz, A., Santos, C., Sarkar, S., Savin, I. A., Sawada, T., Sbrizzai, G., Schiavon, P., Schmidt, K., Schmieden, H., Schoenning, K., Seder, E., Selyunin, A., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Smolik, J., Srnka, A., Steffen, D., Stolarski, M., Subrt, O., Sulc, M., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Tasevsky, M., Tessaro, S., Tessarotto, F., Thiel, A., Tomsa, J., Tosello, F., Tskhay, V., Uhl, S., Vasilishin, B. I., Vauth, A., Veloso, J., Vidon, A., Virius, M., Wallner, S., Weisrock, T., Wilfert, M., ter Wolbeek, J., Zaremba, K., Zavada, P., Zavertyaev, M., Zemlyanichkina, E., Zhuravlev, N., and Ziembicki, M.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

A semi-inclusive measurement of charged hadron multiplicities in deep inelastic muon scattering off an isoscalar target was performed using data collected by the COMPASS Collaboration at CERN. The following kinematic domain is covered by the data: photon virtuality $Q^{2}>1$ (GeV/$c$)$^2$, invariant mass of the hadronic system $W > 5$ GeV/$c^2$, Bjorken scaling variable in the range $0.003 < x < 0.4$, fraction of the virtual photon energy carried by the hadron in the range $0.2 < z < 0.8$, square of the hadron transverse momentum with respect to the virtual photon direction in the range 0.02 (GeV/$c)^2 < P_{\rm{hT}}^{2} < 3$ (GeV/$c$)$^2$. The multiplicities are presented as a function of $P_{\rm{hT}}^{2}$ in three-dimensional bins of $x$, $Q^2$, $z$ and compared to previous semi-inclusive measurements. We explore the small-$P_{\rm{hT}}^{2}$ region, i.e. $P_{\rm{hT}}^{2} < 1$ (GeV/$c$)$^2$, where hadron transverse momenta are expected to arise from non-perturbative effects, and also the domain of larger $P_{\rm{hT}}^{2}$, where contributions from higher-order perturbative QCD are expected to dominate. The multiplicities are fitted using a single-exponential function at small $P_{\rm{hT}}^{2}$ to study the dependence of the average transverse momentum $\langle P_{\rm{hT}}^{2}\rangle$ on $x$, $Q^2$ and $z$. The power-law behaviour of the multiplicities at large $P_{\rm{hT}}^{2}$ is investigated using various functional forms. The fits describe the data reasonably well over the full measured range., Comment: 28 pages, 20 figures

Published
2017
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12. Performance of Multiplexed XY Resistive Micromegas detectors in a high intensity beam

Author

Banerjee, D., Burtsev, V., Chumakov, A., Cooke, D., Depero, E., Dermenev, A. V., Donskov, S. V., Dubinin, F., Dusaev, R. R., Emmenegger, S., Fabich, A., Frolov, V. N., Gardikiotis, A., Gninenko, S. N., Hösgen, M., Karneyeu, A. E., Ketzer, B., Kirsanov, M. M., Konorov, I. V., Kramarenko, V. A., Kuleshov, S. V., Levchenko, E., Lyubovitskij, V. E., Lysan, V., Mamon, S., Matveev, V. A., Mikhailov, Yu. V., Myalkovskiy, V. V., Peshekhonov, V. D., Peshekhonov, D. V., Polyakov, V. A., Radics, B., Rubbia, A., Samoylenko, V. D., Tikhomirov, V. O., Tlisov, D. A., Toropin, A. N., Vasilishin, B., Arenas, G. Vasquez, Ulloa, P., and Crivelli, P.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

We present the performance of multiplexed XY resistive Micromegas detectors tested in the CERN SPS 100 GeV/c electron beam at intensities up to 3.3 $\times$ 10$^5$ e$^- $/(s$\cdot$cm$^2$). So far, all studies with multiplexed Micromegas have only been reported for tests with radioactive sources and cosmic rays. The use of multiplexed modules in high intensity environments was not explored due to the effect of ambiguities in the reconstruction of the hit point caused by the multiplexing feature. At the beam intensities analysed in this work and with a multiplexing factor of 5, more than 50% level of ambiguity is introduced. Our results prove that by using the additional information of cluster size and integrated charge from the signal clusters induced on the XY strips, the ambiguities can be reduced to a level below 2%. The tested detectors are used in the CERN NA64 experiment for tracking the incoming particles bending in a magnetic field in order to reconstruct their momentum. The average hit detection efficiency of each module was found to be $\sim$ 96% at the highest beam intensities. By using four modules a tracking resolution of 1.1% was obtained with $\sim$ 85% combined tracking efficiency.

Published
2017
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13. New analysis of $\eta\pi$ tensor resonances measured at the COMPASS experiment

Author

Jackura, A., Fernandez-Ramirez, C., Mikhasenko, M., Pilloni, A., Mathieu, V., Nys, J., Pauk, V., Szczepaniak, A. P., Fox, G., Aghasyan, M., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anfimov, N. V., Anosov, V., Antoshkin, A., Augsten, K., Augustyniak, W., Austregesilo, A., Azevedo, C. D. R., Badelek, B., Balestra, F., Ball, M., Barth, J., Beck, R., Bedfer, Y., Bernhard, J., Bicker, K., Bielert, E. R., Birsa, R., Bodlak, M., Bordalo, P., Bradamante, F., Bressan, A., Buechele, M., Burtsev, V. E., Chang, W. -C., Chatterjee, C., Chiosso, M., Choi, I., Chumakov, A. G., Chung, S. -U., Cicuttin, A., Crespo, M. L., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Dhara, L., Donskov, S. V., Doshita, N., Dreisbach, Ch., Duennweber, W., Dusaev, R. R., Dziewiecki, M., Efremov, A., Eversheim, P. D., Faessler, M., Ferrero, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Fuchey, E., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giarra, J., Giordano, F., Gnesi, I., Gorzellik, M., Grasso, A., Perdekamp, M. Grosse, Grube, B., Grussenmeyer, T., Guskov, A., Hahne, D., Hamar, G., von Harrach, D., Heinsius, F. H., Heitz, R., Herrmann, F., Horikawa, N., d'Hose, N., Hsieh, C. -Y., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jary, V., Joosten, R., Joerg, P., Kabuss, E., Kerbizi, A., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O. M., Kral, Z., Kraemer, M., Kremser, P., Krinner, F., Kroumchtein, Z. V., Kulinich, Y., Kunne, F., Kurek, K., Kurjata, R. P., Kuznetsov, I. I., Kveton, A., Lednev, A. A., Levchenko, E. A., Levillain, M., Levorato, S., Lian, Y. -S., Lichtenstadt, J., Longo, R., Lyubovitskij, V. E., Maggiora, A., Magnon, A., Makins, N., Makke, N., Mallot, G. K., Mamon, S. A., Marianski, B., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G. V., Meyer, M., Meyer, W., Mikhailov, Yu. V., Mitrofanov, E., Mitrofanov, N., Miyachi, Y., Nagaytsev, A., Nerling, F., Neyret, D., Novy, J., Nowak, W. -D., Nukazuka, G., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J. -C., Pereira, F., Pesek, M., Peskova, M., Peshekhonov, D. V., Pierre, N., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Riedl, C., Rogacheva, N. S., Ryabchikov, D. I., Rybnikov, A., Rychter, A., Salac, R., Samoylenko, V. D., Sandacz, A., Santos, C., Sarkar, S., Savin, I. A., Sawada, T., Sbrizzai, G., Schiavon, P., Schluter, T., Schmidt, K., Schmieden, H., Schoenning, K., Seder, E., Selyunin, A., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Smolik, J., Srnka, A., Steffen, D., Stolarski, M., Subrt, O., Sulc, M., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Tasevsky, M., Tessaro, S., Tessarotto, F., Thiel, A., Tomsa, J., Tosello, F., Tskhay, V., Uhl, S., Vasilishin, B. I., Vauth, A., Veloso, J., Vidon, A., Virius, M., Wallner, S., Weisrock, T., Wilfert, M., ter Wolbeek, J., Zaremba, K., Zavada, P., Zavertyaev, M., Zemlyanichkina, E., Zhuravlev, N., and Ziembicki, M.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

We present a new amplitude analysis of the $\eta\pi$ $D$-wave in $\pi^- p\to \eta\pi^- p$ measured by COMPASS. Employing an analytical model based on the principles of the relativistic $S$-matrix, we find two resonances that can be identified with the $a_2(1320)$ and the excited $a_2^\prime(1700)$, and perform a comprehensive analysis of their pole positions. For the mass and width of the $a_2$ we find $M=(1307 \pm 1 \pm 6)$~MeV and $\Gamma=(112 \pm 1 \pm 8)$~MeV, and for the excited state $a_2^\prime$ we obtain $M=(1720 \pm 10 \pm 60)$~MeV and $\Gamma=(280\pm 10 \pm 70)$~MeV, respectively., Comment: 15 pages, 6 figures

Published
2017
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14. Search for muoproduction of $X(3872)$ at COMPASS and indication of a new state $\widetilde{X}(3872)$

Author

Aghasyan, M., Akhunzyanov, R., Alexeev, M. G., Alexeev, G. D., Amoroso, A., Andrieux, V., Anfimov, N. V., Anosov, V., Antoshkin, A., Augsten, K., Augustyniak, W., Austregesilo, A., Azevedo, C. D. R., Badelek, B., Balestra, F., Ball, M., Barth, J., Beck, R., Bedfer, Y., Bernhard, J., Bicker, K., Bielert, E. R., Birsa, R., Bodlak, M., Bordalo, P., Bradamante, F., Bressan, A., Buechele, M., Burtsev, V. E., Chang, W. -C., Chatterjee, C., Chiosso, M., Choi, I., Chumakov, A. G., Chung, S. -U., Cicuttin, A., Crespo, M. L., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Denisov, O. Yu., Dhara, L., Donskov, S. V., Doshita, N., Dreisbach, Ch., Duennweber, W., Dusaev, R. R., Dziewiecki, M., Efremov, A., Eversheim, P. D., Faessler, M., Ferrero, A., Finger, M., Finger jr., M., Fischer, H., Franco, C., von Hohenesche, N. du Fresne, Friedrich, J. M., Frolov, V., Fuchey, E., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giarra, J., Giordano, F., Gnesi, I., Gorzellik, M., Grasso, A., Gridin, A., Perdekamp, M. Grosse, Grube, B., Grussenmeyer, T., Guskov, A., Hahne, D., Hamar, G., von Harrach, D., Heinsius, F. H., Heitz, R., Herrmann, F., Horikawa, N., d'Hose, N., Hsieh, C. -Y., Huber, S., Ishimoto, S., Ivanov, A., Ivanshin, Yu., Iwata, T., Jary, V., Joosten, R., Joerg, P., Kabuss, E., Kerbizi, A., Ketzer, B., Khaustov, G. V., Khokhlov, Yu. A., Kisselev, Yu., Klein, F., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O. M., Kral, Z., Kraemer, M., Kremser, P., Krinner, F., Kroumchtein, Z. V., Kulinich, Y., Kunne, F., Kurek, K., Kurjata, R. P., Kuznetsov, I. I., Kveton, A., Lednev, A. A., Levchenko, E. A., Levillain, M., Levorato, S., Lian, Y. -S., Lichtenstadt, J., Longo, R., Lyubovitskij, V. E., Maggiora, A., Magnon, A., Makins, N., Makke, N., Mallot, G. K., Mamon, S. A., Marianski, B., Martin, A., Marzec, J., Matousek, J., Matsuda, H., Matsuda, T., Meshcheryakov, G. V., Meyer, M., Meyer, W., Mikhailov, Yu. V., Mikhasenko, M., Mitrofanov, E., Mitrofanov, N., Miyachi, Y., Nagaytsev, A., Nerling, F., Neyret, D., Novy, J., Nowak, W. -D., Nukazuka, G., Nunes, A. S., Olshevsky, A. G., Orlov, I., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Peng, J. -C., Pereira, F., Pesek, M., Peskova, M., Peshekhonov, D. V., Pierre, N., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Regali, C., Reicherz, G., Riedl, C., Rogacheva, N. S., Ryabchikov, D. I., Rybnikov, A., Rychter, A., Salac, R., Samoylenko, V. D., Sandacz, A., Santos, C., Sarkar, S., Savin, I. A., Sawada, T., Sbrizzai, G., Schiavon, P., Schmidt, K., Schmieden, H., Schoenning, K., Seder, E., Selyunin, A., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Smolik, J., Srnka, A., Steffen, D., Stolarski, M., Subrt, O., Sulc, M., Suzuki, H., Szabelski, A., Szameitat, T., Sznajder, P., Tasevsky, M., Tessaro, S., Tessarotto, F., Thiel, A., Tomsa, J., Tosello, F., Tskhay, V., Uhl, S., Vasilishin, B. I., Vauth, A., Veloso, J., Vidon, A., Virius, M., Wallner, S., Weisrock, T., Wilfert, M., ter Wolbeek, J., Zaremba, K., Zavada, P., Zavertyaev, M., Zemlyanichkina, E., Zhuravlev, N., and Ziembicki, M.

Subjects
High Energy Physics - Experiment
Abstract

We have searched for exclusive production of exotic charmonia in the reaction $\mu^+~N \rightarrow \mu^+ (J\!/\!\psi\pi^+\pi^-)\pi^{\pm}~N'$ using COMPASS data collected with incoming muons of 160 GeV/$c$ and 200 GeV/$c$ momentum. In the $J\!/\!\psi\pi^+\pi^-$ mass distribution we observe a signal with a statistical significance of 4.1 $\sigma$. Its mass and width are consistent with those of the $X(3872)$. The shape of the $\pi^+\pi^-$ mass distribution from the observed decay into $J\!/\!\psi\pi^+\pi^-$ shows disagreement with previous observations for $X(3872)$. The observed signal may be interpreted as a possible evidence of a new charmonium state. It could be associated with a neutral partner of $X(3872)$ with $C = -1$ predicted by a tetraquark model. The product of cross section and branching fraction of the decay of the observed state into $J\!/\!\psi\pi^+\pi^-$ is determined to be 71$\pm$28(stat)$\pm$39(syst) pb., Comment: 12 pages, 6 figures

Published
2017
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15. Calculation of Contact Tensions in the Process of Thermofrictional Treatment

Author

Pokintelitsa, N., Levchenko, E., Cavas-Martínez, Francisco, Series Editor, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Haddar, Mohamed, Series Editor, Ivanov, Vitalii, Series Editor, Kwon, Young W., Series Editor, Trojanowska, Justyna, Series Editor, di Mare, Francesca, Series Editor, Radionov, Andrey A., editor, and Gasiyarov, Vadim R., editor

Published
2021
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17. Mathematical Modeling of the Kinetics of Counter Diffusion During the Formation of Boron-Containing Coatings on Steels

Author

Borsyakov, A. S., Yuryev, V. A., Ozyerelyev, V. V., Levchenko, E. V., Hull, Robert, Series Editor, Jagadish, Chennupati, Series Editor, Kawazoe, Yoshiyuki, Series Editor, Kruzic, Jamie, Series Editor, Osgood, Richard M., Series Editor, Parisi, Jürgen, Series Editor, Pohl, Udo W., Series Editor, Seong, Tae-Yeon, Series Editor, Uchida, Shin-ichi, Series Editor, Wang, Zhiming M., Series Editor, Levchenko, Elena V., editor, Dappe, Yannick J., editor, and Ori, Guido, editor

Published
2020
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18. Diffusion Kinetics in Binary Liquid Alloys with Ordering and Demixing Tendencies

Author

Kromik, Andreas, Levchenko, E. V., Evteev, Alexander V., Hull, Robert, Series Editor, Jagadish, Chennupati, Series Editor, Kawazoe, Yoshiyuki, Series Editor, Kruzic, Jamie, Series Editor, Osgood, Richard M., Series Editor, Parisi, Jürgen, Series Editor, Pohl, Udo W., Series Editor, Seong, Tae-Yeon, Series Editor, Uchida, Shin-ichi, Series Editor, Wang, Zhiming M., Series Editor, Levchenko, Elena V., editor, Dappe, Yannick J., editor, and Ori, Guido, editor

Published
2020
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19. Simulation of the Phonon Drag of Point Defects in a Harmonic Crystal

Author

Bataronov, I. L., Yuryev, V. A., Levchenko, E. V., Yuryeva, M. V., Yuyukin, N. A., Hull, Robert, Series Editor, Jagadish, Chennupati, Series Editor, Kawazoe, Yoshiyuki, Series Editor, Kruzic, Jamie, Series Editor, Osgood, Richard M., Series Editor, Parisi, Jürgen, Series Editor, Pohl, Udo W., Series Editor, Seong, Tae-Yeon, Series Editor, Uchida, Shin-ichi, Series Editor, Wang, Zhiming M., Series Editor, Levchenko, Elena V., editor, Dappe, Yannick J., editor, and Ori, Guido, editor

Published
2020
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20. Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/K-mutant melanoma: long-term survival and safety analysis of a phase 3 study

Author

Long, GV, Flaherty, KT, Stroyakovskiy, D, Gogas, H, Levchenko, E, de Braud, F, Larkin, J, Garbe, C, Jouary, T, Hauschild, A, Chiarion-Sileni, V, Lebbe, C, Mandalà, M, Millward, M, Arance, A, Bondarenko, I, Haanen, JBAG, Hansson, J, Utikal, J, Ferraresi, V, Mohr, P, Probachai, V, Schadendorf, D, Nathan, P, Robert, C, Ribas, A, Davies, MA, Lane, SR, Legos, JJ, Mookerjee, B, and Grob, J-J

Subjects
Cancer, Clinical Research, Clinical Trials and Supportive Activities, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Disease Progression, Disease-Free Survival, Double-Blind Method, Drug Administration Schedule, Humans, Imidazoles, Kaplan-Meier Estimate, Melanoma, Mutation, Oximes, Protein Kinase Inhibitors, Proto-Oncogene Proteins B-raf, Pyridones, Pyrimidinones, Risk Factors, Skin Neoplasms, Time Factors, Treatment Outcome, melanoma, metastatic, BRAF, dabrafenib, trametinib, durable outcomes, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundPrevious analysis of COMBI-d (NCT01584648) demonstrated improved progression-free survival (PFS) and overall survival (OS) with combination dabrafenib and trametinib versus dabrafenib monotherapy in BRAF V600E/K-mutant metastatic melanoma. This study was continued to assess 3-year landmark efficacy and safety after ≥36-month follow-up for all living patients.Patients and methodsThis double-blind, phase 3 study enrolled previously untreated patients with BRAF V600E/K-mutant unresectable stage IIIC or stage IV melanoma. Patients were randomized to receive dabrafenib (150 mg twice daily) plus trametinib (2 mg once daily) or dabrafenib plus placebo. The primary endpoint was PFS; secondary endpoints were OS, overall response, duration of response, safety, and pharmacokinetics.ResultsBetween 4 May and 30 November 2012, a total of 423 of 947 screened patients were randomly assigned to receive dabrafenib plus trametinib (n = 211) or dabrafenib monotherapy (n = 212). At data cut-off (15 February 2016), outcomes remained superior with the combination: 3-year PFS was 22% with dabrafenib plus trametinib versus 12% with monotherapy, and 3-year OS was 44% versus 32%, respectively. Twenty-five patients receiving monotherapy crossed over to combination therapy, with continued follow-up under the monotherapy arm (per intent-to-treat principle). Of combination-arm patients alive at 3 years, 58% remained on dabrafenib plus trametinib. Three-year OS with the combination reached 62% in the most favourable subgroup (normal lactate dehydrogenase and

Published
2017

21. Branching of the vortex nucleation period in superconductor Nb microtubes due to inhomogeneous transport current

Author

Rezaev, R. O., Levchenko, E. A., and Fomin, V. M.

Subjects
Condensed Matter - Superconductivity
Abstract

An inhomogeneous transport current, which is introduced through multiple electrodes in an open Nb microtube, is shown to lead to a controllable branching of the vortex nucleation period. The detailed mechanism of this branching is analyzed using the time-dependent Ginzburg-Landau equation. The relative change of the vortex nucleation period strongly depends on the geometry of multiple electrodes. The average number of vortices occurring in the tube in a nanosecond can be effectively reduced owing to the inhomogeneous transport current, what is important for noise and energy dissipation reduction in superconductor applications, e.g., for an extension of the operation regime of superconductor-based sensors to lower frequencies., Comment: 8 pages, 4 figures

Published
2015
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29. Pattern formation in terms of semiclassically limited distribution on lower-dimensional manifolds for nonlocal Fisher--Kolmogorov--Petrovskii--Piskunov equation

Author

Levchenko, E. A., Shapovalov, A. V., and Trifonov, A. Yu

Subjects
Mathematical Physics
Abstract

We have investigated the pattern formation in systems described by the nonlocal Fisher--Kolmogorov--Petrovskii--Piskunov equation for the cases where the dimension of the pattern concentration area is less than that of independent variables space. We have obtained a system of integro-differential equations which describe the dynamics of the concentration area and the semiclassically limited distribution of a pattern in the class of trajectory concentrated functions. Also, asymptotic large-time solutions have been obtained that describe the semiclassically limited distribution of a quasi-steady-state pattern on the concentration manifold. The approach is illustrated by an example for which the analytical solution is in good agreement with the prediction of a numerical simulation., Comment: 22 pages, 8 figures

Published
2013
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34. Performance of Multiplexed XY Resistive Micromegas detectors in a high intensity beam

Author

Banerjee, D., Burtsev, V., Chumakov, A., Cooke, D., Depero, E., Dermenev, A.V., Donskov, S.V., Dubinin, F., Dusaev, R.R., Emmenegger, S., Fabich, A., Frolov, V.N., Gardikiotis, A., Gninenko, S.N., Hösgen, M., Karneyeu, A.E., Ketzer, B., Kirsanov, M.M., Konorov, I.V., Kramarenko, V.A., Kuleshov, S.V., Levchenko, E., Lyubovitskij, V.E., Lysan, V., Mamon, S., Matveev, V.A., Mikhailov, Yu.V., Myalkovskiy, V.V., Peshekhonov, V.D., Peshekhonov, D.V., Polyakov, V.A., Radics, B., Rubbia, A., Samoylenko, V.D., Tikhomirov, V.O., Tlisov, D.A., Toropin, A.N., Vasilishin, B., Arenas, G. Vasquez, Ulloa, P., and Crivelli, P.

Published
2018
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41. Perioperative Pembrolizumab for Early-Stage Non-Small-Cell Lung Cancer

Author

Heather, W, Moishe, L, Terufumi, K, Masahiro, T, Se-Hoon, L, Shugeng, G, Ke-Neng, C, Christophe, D, Margarita, M, Ekkehard, E, Gastón L, M, Olivier, B, Delvys, R, Jamie E, C, Silvia, N, Jing, Y, Steven M, K, Ayman, S, Spicer, D Marcelo Tatangelo, J, Flores, M, Pastor, A, Puig, J, Martinengo, G, Varela, M, Brocca, C, Wong, M, Hui, R, Dooms, C, Vansteenkiste, J, Demedts, I, Sibille, A, Surmont, V, Deschepper, K, Lambrechts, M, Dias, J, Rafael Martins De Marchi, P, Alves, G, Henrique Araujo, L, Matias, D, Chaves, F, Franke, F, Teixeira, C, Tabacof, J, Faria, L, Morbeck, I, Henrique Cronemberger, E, Lima, I, Sardenberg, R, de Paiva Junior, T, Dutra, C, Luiz Guimaraes, J, Begin, P, Langleben, A, Liu, G, Liberman, M, Spicer, J, Gao, S, Zhao, G, Jiang, T, Yan, X, Hu, J, Chen, J, Tan, L, Wang, Q, Li, S, Chen, K, Yang, Y, Bai, J, Ma, S, Chen, H, Chen, Q, Wang, W, Zhang, L, Zhu, Y, Vanakesa, T, Zasadny, X, Duchemann, B, Girard, N, Bylicki, O, Berard, H, Thiberville, L, Mennecier, B, Mazieres, J, Eigendorff, E, Bonnet, R, Fix, P, Reck, M, Rittmeyer, A, Reinacher-Schick, A, Wehler, T, Lehmann, M, Serke, M, Wesseler, C, Täuscher, D, Lang, S, Wermke, M, Grohe, C, Wirtz, H, Kollmeier, J, Ritgen, M, Mueller, A, Frohling, K, Vogel, G, Faehling, M, Cuffe, S, Collins, D, Delmonte, A, Gilli, M, Piantedosi, F, Ogliari, F, Bulotta, A, Gregorc, V, Gianni, L, Grisanti, S, Intagliata, S, Roca, E, Ferrari, V, Berruti, A, Cortinovis, D, Lo Russo, G, Ferrara, R, Garassino, M, Rita Migliorino, M, Novello, S, Santoro, A, Signorelli, D, Tsuboi, M, Okada, M, Kato, T, Nishio, W, Kuroda, H, Shimizu, J, Sakao, Y, Sugio, K, Horinouchi, H, Takamochi, K, Saji, H, Tanaka, F, Ikeda, N, Muto, S, Shio, Y, Suzuki, H, Hegmane, A, Cicenas, S, Zemaitis, M, Kek Pang, Y, Yew Heng, F, Leong Yu, K, Lowczak, A, Makles, K, Bryl, M, Zurawski, B, Pawlak, I, Han, J, Lee, S, Kim, J, Yong Shim, B, Cebotaru, C, Ganea, D, Scheusan, R, Ciurescu, I, Mazilu, L, Ungureanu, A, Gal, C, Ciubotaru, E, Iordan, I, Berceanu-Ion, R, Ciuleanu, T, Laktionov, K, Karaseva, N, Smagina, M, Luft, A, Afanasyev, S, Nesterova, A, Levchenko, E, Arkhipov, A, Fedenko, A, Ruff, P, Jacobs, C, Fourie, S, Carcereny, E, Calles Blanco, A, Rodriguez Abreu, D, Majem Tarruella, M, Bosch Barrera, J, Bernabe Caro, R, Nadal Alforja, E, Martnez Marti, A, Liao, B, Huang, H, Chiu, C, Wang, C, Tsai, C, Voitko, N, Kryzhanivska, A, Kolesnik, O, Levenko, O, Bondarenko, I, Trukhin, D, Ursol, G, Paramonov, V, Sokur, I, Khan, S, Arora, A, Goranov, B, Greystoke, A, Ahmed, S, Pope, T, O'Brien, M, Charu, V, Cobb, P, Costin, D, Weksler, B, Schumacher, L, Finley, G, Furqan, M, Gentzler, R, Misleh, J, Guarino, M, Halmos, B, Keresztes, R, Jain, K, Yan Lou, Y, Molina, J, Liu-Dumlao, T, Zhao, Q, Niu, J, Taysir Hammoud, Z, Rybkin, I, Cuevo, R, Fernando, H, Schiller, J, Srkalovic, G, Koontz, M, Stampleman, L, Anderson, I, Villaruz, L, Wang, S, Komiya, T, Jain, S, Starodub, A, Wakelee, H, Kishor Ganti, A, Ernani, V, Kristedja, T, O'Day, S, Radhi, S, Sangal, A, Duvivier, H, Rich, P, Kazmi, S, Pollock, T, Chaft, J, Rathnasabapathy, C, Savvides, P, Costas, K, Kaywin, P, Villalona-Calero, M, Alekshun, T, Rao, S, Siegel, R, Wakelee, Heather, Liberman, Moishe, Kato, Terufumi, Tsuboi, Masahiro, Lee, Se-Hoon, Gao, Shugeng, Chen, Ke-Neng, Dooms, Christophe, Majem, Margarita, Eigendorff, Ekkehard, Martinengo, Gastón L, Bylicki, Olivier, Rodríguez-Abreu, Delvys, Chaft, Jamie E, Novello, Silvia, Yang, Jing, Keller, Steven M, Samkari, Ayman, Jonathan D Marcelo Tatangelo, Marcos Flores, Andrea Pastor, Juan Puig, Gaston Martinengo, Mirta Varela, Carlos Brocca, Mark Wong, Rina Hui, Christophe Dooms, Johan Vansteenkiste, Ingel Demedts, Anne Sibille, Veerle Surmont, Koenraad Deschepper, Marc Lambrechts, Josiane Dias, Pedro Rafael Martins De Marchi, Gustavo Alves, Luiz Henrique Araujo, Danielli Matias, Fabio Chaves, Fabio Franke, Carlos Teixeira, Jacques Tabacof, Luiza Faria, Igor Morbeck, Eduardo Henrique Cronemberger, Iane Lima, Rodrigo Sardenberg, Tadeu de Paiva Junior, Carolina Dutra, Jose Luiz Guimaraes, Paul Begin, Adrian Langleben, Geoffrey Liu, Moishe Liberman, Jonathan Spicer, Shugeng Gao, Guofang Zhao, Tao Jiang, Xiaolong Yan, Jian Hu, Jun Chen, Lijie Tan, Qun Wang, Shanqing Li, Keneng Chen, Yue Yang, Jie Bai, Shaohua Ma, Haiquan Chen, Qixun Chen, Wenxiang Wang, Lanjun Zhang, Yuming Zhu, Tonu Vanakesa, Xavier Zasadny, Boris Duchemann, Nicolas Girard, Olivier Bylicki, Henri Berard, Luc Thiberville, Bertrand Mennecier, Julien Mazieres, Ekkehard Eigendorff, Reiner Bonnet, Peter Fix, Martin Reck, Achim Rittmeyer, Anke Reinacher-Schick, Thomas Wehler, Markus Lehmann, Monika Serke, Claas Wesseler, Dagmar Täuscher, Susanne Lang, Martin Wermke, Christian Grohe, Hubert Wirtz, Jens Kollmeier, Mathias Ritgen, Annette Mueller, Klaus-Peter Frohling, Gunther Vogel, Martin Faehling, Sinead Cuffe, Dearbhaile Collins, Angelo Delmonte, Marina Gilli, Francovito Piantedosi, Francesca Ogliari, Alessandra Bulotta, Vanesa Gregorc, Luca Gianni, Salvatore Grisanti, Salvatore Intagliata, Elisa Roca, Vittorio Ferrari, Alfredo Berruti, Diego Cortinovis, Giuseppe Lo Russo, Roberto Ferrara, Marina Garassino, Maria Rita Migliorino, Silvia Novello, Armando Santoro, Diego Signorelli, Masahiro Tsuboi, Morihito Okada, Terufumi Kato, Wataru Nishio, Hiroaki Kuroda, Junichi Shimizu, Yukinori Sakao, Kenji Sugio, Hidehito Horinouchi, Kazuya Takamochi, Hisashi Saji, Fumihiro Tanaka, Norihiko Ikeda, Satoshi Muto, Yutaka Shio, Hiroyuki Suzuki, Alinta Hegmane, Saulius Cicenas, Marius Zemaitis, Yong Kek Pang, Fook Yew Heng, Kong Leong Yu, Anna Lowczak, Krytsyna Makles, Maciej Bryl, Bogdan Zurawski, Ireneusz Pawlak, Ji-Youn Han, Se-Hoon Lee, Jhingook Kim, Byoung Yong Shim, Cristina Cebotaru, Doina Ganea, Roxana Scheusan, Ioana Ciurescu, Laura Mazilu, Andrei Ungureanu, Cristian Gal, Elena Ciubotaru, Ingrid Iordan, Radu Berceanu-Ion, Tudor Ciuleanu, Konstantin Laktionov, Nina Karaseva, Maria Smagina, Alexander Luft, Sergey Afanasyev, Alfiya Nesterova, Evgeny Levchenko, Alexander Arkhipov, Alexander Fedenko, Paul Ruff, Conrad Jacobs, Samuel Fourie, Enric Carcereny, Antonio Calles Blanco, Delvys Rodriguez Abreu, Margarita Majem Tarruella, Joaquim Bosch Barrera, Reyes Bernabe Caro, Ernest Nadal Alforja, Alex Martnez Marti, Bin-Chi Liao, Hsu-Ching Huang, Chao-Hua Chiu, Chin-Chou Wang, Chen-Liang Tsai, Nataliia Voitko, Anna Kryzhanivska, Olena Kolesnik, Oleh Levenko, Oleksii Kolesnik, Igor Bondarenko, Dmytro Trukhin, Grygorii Ursol, Viktor Paramonov, Iryna Sokur, Sarah Khan, Arvind Arora, Bojidar Goranov, Alastair Greystoke, Samreen Ahmed, Tony Pope, Mary O'Brien, Veena Charu, Patrick Cobb, Dan Costin, Benny Weksler, Lana Schumacher, Gene Finley, Muhammad Furqan, Ryan Gentzler, Jamal Misleh, Michael Guarino, Balazs Halmos, Roger Keresztes, Kirti Jain, Yan Yan Lou, Julian Molina, Theresa Liu-Dumlao, Qing Zhao, Jiaxin Niu, Zane Taysir Hammoud, Igor Rybkin, Raymund Cuevo, Hiran Fernando, Joan Schiller, Gordan Srkalovic, Michael Koontz, Laura Stampleman, Ian Anderson, Liza Villaruz, Sarah Wang, Takefumi Komiya, Sushil Jain, Alexander Starodub, Heather Wakelee, Apar Kishor Ganti, Vinicius Ernani, Timothy Kristedja, Steven O'Day, Saba Radhi, Ashish Sangal, Herbert Duvivier, Patricia Rich, Shayma Kazmi, Theodore Pollock, Jamie Chaft, Chenthilmurugan Rathnasabapathy, Panayiotis Savvides, Kimberly Costas, Paul Kaywin, Miguel Villalona-Calero, Todd Alekshun, Kevin Chen, Suman Rao, Robert Siegel, Heather, W, Moishe, L, Terufumi, K, Masahiro, T, Se-Hoon, L, Shugeng, G, Ke-Neng, C, Christophe, D, Margarita, M, Ekkehard, E, Gastón L, M, Olivier, B, Delvys, R, Jamie E, C, Silvia, N, Jing, Y, Steven M, K, Ayman, S, Spicer, D Marcelo Tatangelo, J, Flores, M, Pastor, A, Puig, J, Martinengo, G, Varela, M, Brocca, C, Wong, M, Hui, R, Dooms, C, Vansteenkiste, J, Demedts, I, Sibille, A, Surmont, V, Deschepper, K, Lambrechts, M, Dias, J, Rafael Martins De Marchi, P, Alves, G, Henrique Araujo, L, Matias, D, Chaves, F, Franke, F, Teixeira, C, Tabacof, J, Faria, L, Morbeck, I, Henrique Cronemberger, E, Lima, I, Sardenberg, R, de Paiva Junior, T, Dutra, C, Luiz Guimaraes, J, Begin, P, Langleben, A, Liu, G, Liberman, M, Spicer, J, Gao, S, Zhao, G, Jiang, T, Yan, X, Hu, J, Chen, J, Tan, L, Wang, Q, Li, S, Chen, K, Yang, Y, Bai, J, Ma, S, Chen, H, Chen, Q, Wang, W, Zhang, L, Zhu, Y, Vanakesa, T, Zasadny, X, Duchemann, B, Girard, N, Bylicki, O, Berard, H, Thiberville, L, Mennecier, B, Mazieres, J, Eigendorff, E, Bonnet, R, Fix, P, Reck, M, Rittmeyer, A, Reinacher-Schick, A, Wehler, T, Lehmann, M, Serke, M, Wesseler, C, Täuscher, D, Lang, S, Wermke, M, Grohe, C, Wirtz, H, Kollmeier, J, Ritgen, M, Mueller, A, Frohling, K, Vogel, G, Faehling, M, Cuffe, S, Collins, D, Delmonte, A, Gilli, M, Piantedosi, F, Ogliari, F, Bulotta, A, Gregorc, V, Gianni, L, Grisanti, S, Intagliata, S, Roca, E, Ferrari, V, Berruti, A, Cortinovis, D, Lo Russo, G, Ferrara, R, Garassino, M, Rita Migliorino, M, Novello, S, Santoro, A, Signorelli, D, Tsuboi, M, Okada, M, Kato, T, Nishio, W, Kuroda, H, Shimizu, J, Sakao, Y, Sugio, K, Horinouchi, H, Takamochi, K, Saji, H, Tanaka, F, Ikeda, N, Muto, S, Shio, Y, Suzuki, H, Hegmane, A, Cicenas, S, Zemaitis, M, Kek Pang, Y, Yew Heng, F, Leong Yu, K, Lowczak, A, Makles, K, Bryl, M, Zurawski, B, Pawlak, I, Han, J, Lee, S, Kim, J, Yong Shim, B, Cebotaru, C, Ganea, D, Scheusan, R, Ciurescu, I, Mazilu, L, Ungureanu, A, Gal, C, Ciubotaru, E, Iordan, I, Berceanu-Ion, R, Ciuleanu, T, Laktionov, K, Karaseva, N, Smagina, M, Luft, A, Afanasyev, S, Nesterova, A, Levchenko, E, Arkhipov, A, Fedenko, A, Ruff, P, Jacobs, C, Fourie, S, Carcereny, E, Calles Blanco, A, Rodriguez Abreu, D, Majem Tarruella, M, Bosch Barrera, J, Bernabe Caro, R, Nadal Alforja, E, Martnez Marti, A, Liao, B, Huang, H, Chiu, C, Wang, C, Tsai, C, Voitko, N, Kryzhanivska, A, Kolesnik, O, Levenko, O, Bondarenko, I, Trukhin, D, Ursol, G, Paramonov, V, Sokur, I, Khan, S, Arora, A, Goranov, B, Greystoke, A, Ahmed, S, Pope, T, O'Brien, M, Charu, V, Cobb, P, Costin, D, Weksler, B, Schumacher, L, Finley, G, Furqan, M, Gentzler, R, Misleh, J, Guarino, M, Halmos, B, Keresztes, R, Jain, K, Yan Lou, Y, Molina, J, Liu-Dumlao, T, Zhao, Q, Niu, J, Taysir Hammoud, Z, Rybkin, I, Cuevo, R, Fernando, H, Schiller, J, Srkalovic, G, Koontz, M, Stampleman, L, Anderson, I, Villaruz, L, Wang, S, Komiya, T, Jain, S, Starodub, A, Wakelee, H, Kishor Ganti, A, Ernani, V, Kristedja, T, O'Day, S, Radhi, S, Sangal, A, Duvivier, H, Rich, P, Kazmi, S, Pollock, T, Chaft, J, Rathnasabapathy, C, Savvides, P, Costas, K, Kaywin, P, Villalona-Calero, M, Alekshun, T, Rao, S, Siegel, R, Wakelee, Heather, Liberman, Moishe, Kato, Terufumi, Tsuboi, Masahiro, Lee, Se-Hoon, Gao, Shugeng, Chen, Ke-Neng, Dooms, Christophe, Majem, Margarita, Eigendorff, Ekkehard, Martinengo, Gastón L, Bylicki, Olivier, Rodríguez-Abreu, Delvys, Chaft, Jamie E, Novello, Silvia, Yang, Jing, Keller, Steven M, Samkari, Ayman, Jonathan D Marcelo Tatangelo, Marcos Flores, Andrea Pastor, Juan Puig, Gaston Martinengo, Mirta Varela, Carlos Brocca, Mark Wong, Rina Hui, Christophe Dooms, Johan Vansteenkiste, Ingel Demedts, Anne Sibille, Veerle Surmont, Koenraad Deschepper, Marc Lambrechts, Josiane Dias, Pedro Rafael Martins De Marchi, Gustavo Alves, Luiz Henrique Araujo, Danielli Matias, Fabio Chaves, Fabio Franke, Carlos Teixeira, Jacques Tabacof, Luiza Faria, Igor Morbeck, Eduardo Henrique Cronemberger, Iane Lima, Rodrigo Sardenberg, Tadeu de Paiva Junior, Carolina Dutra, Jose Luiz Guimaraes, Paul Begin, Adrian Langleben, Geoffrey Liu, Moishe Liberman, Jonathan Spicer, Shugeng Gao, Guofang Zhao, Tao Jiang, Xiaolong Yan, Jian Hu, Jun Chen, Lijie Tan, Qun Wang, Shanqing Li, Keneng Chen, Yue Yang, Jie Bai, Shaohua Ma, Haiquan Chen, Qixun Chen, Wenxiang Wang, Lanjun Zhang, Yuming Zhu, Tonu Vanakesa, Xavier Zasadny, Boris Duchemann, Nicolas Girard, Olivier Bylicki, Henri Berard, Luc Thiberville, Bertrand Mennecier, Julien Mazieres, Ekkehard Eigendorff, Reiner Bonnet, Peter Fix, Martin Reck, Achim Rittmeyer, Anke Reinacher-Schick, Thomas Wehler, Markus Lehmann, Monika Serke, Claas Wesseler, Dagmar Täuscher, Susanne Lang, Martin Wermke, Christian Grohe, Hubert Wirtz, Jens Kollmeier, Mathias Ritgen, Annette Mueller, Klaus-Peter Frohling, Gunther Vogel, Martin Faehling, Sinead Cuffe, Dearbhaile Collins, Angelo Delmonte, Marina Gilli, Francovito Piantedosi, Francesca Ogliari, Alessandra Bulotta, Vanesa Gregorc, Luca Gianni, Salvatore Grisanti, Salvatore Intagliata, Elisa Roca, Vittorio Ferrari, Alfredo Berruti, Diego Cortinovis, Giuseppe Lo Russo, Roberto Ferrara, Marina Garassino, Maria Rita Migliorino, Silvia Novello, Armando Santoro, Diego Signorelli, Masahiro Tsuboi, Morihito Okada, Terufumi Kato, Wataru Nishio, Hiroaki Kuroda, Junichi Shimizu, Yukinori Sakao, Kenji Sugio, Hidehito Horinouchi, Kazuya Takamochi, Hisashi Saji, Fumihiro Tanaka, Norihiko Ikeda, Satoshi Muto, Yutaka Shio, Hiroyuki Suzuki, Alinta Hegmane, Saulius Cicenas, Marius Zemaitis, Yong Kek Pang, Fook Yew Heng, Kong Leong Yu, Anna Lowczak, Krytsyna Makles, Maciej Bryl, Bogdan Zurawski, Ireneusz Pawlak, Ji-Youn Han, Se-Hoon Lee, Jhingook Kim, Byoung Yong Shim, Cristina Cebotaru, Doina Ganea, Roxana Scheusan, Ioana Ciurescu, Laura Mazilu, Andrei Ungureanu, Cristian Gal, Elena Ciubotaru, Ingrid Iordan, Radu Berceanu-Ion, Tudor Ciuleanu, Konstantin Laktionov, Nina Karaseva, Maria Smagina, Alexander Luft, Sergey Afanasyev, Alfiya Nesterova, Evgeny Levchenko, Alexander Arkhipov, Alexander Fedenko, Paul Ruff, Conrad Jacobs, Samuel Fourie, Enric Carcereny, Antonio Calles Blanco, Delvys Rodriguez Abreu, Margarita Majem Tarruella, Joaquim Bosch Barrera, Reyes Bernabe Caro, Ernest Nadal Alforja, Alex Martnez Marti, Bin-Chi Liao, Hsu-Ching Huang, Chao-Hua Chiu, Chin-Chou Wang, Chen-Liang Tsai, Nataliia Voitko, Anna Kryzhanivska, Olena Kolesnik, Oleh Levenko, Oleksii Kolesnik, Igor Bondarenko, Dmytro Trukhin, Grygorii Ursol, Viktor Paramonov, Iryna Sokur, Sarah Khan, Arvind Arora, Bojidar Goranov, Alastair Greystoke, Samreen Ahmed, Tony Pope, Mary O'Brien, Veena Charu, Patrick Cobb, Dan Costin, Benny Weksler, Lana Schumacher, Gene Finley, Muhammad Furqan, Ryan Gentzler, Jamal Misleh, Michael Guarino, Balazs Halmos, Roger Keresztes, Kirti Jain, Yan Yan Lou, Julian Molina, Theresa Liu-Dumlao, Qing Zhao, Jiaxin Niu, Zane Taysir Hammoud, Igor Rybkin, Raymund Cuevo, Hiran Fernando, Joan Schiller, Gordan Srkalovic, Michael Koontz, Laura Stampleman, Ian Anderson, Liza Villaruz, Sarah Wang, Takefumi Komiya, Sushil Jain, Alexander Starodub, Heather Wakelee, Apar Kishor Ganti, Vinicius Ernani, Timothy Kristedja, Steven O'Day, Saba Radhi, Ashish Sangal, Herbert Duvivier, Patricia Rich, Shayma Kazmi, Theodore Pollock, Jamie Chaft, Chenthilmurugan Rathnasabapathy, Panayiotis Savvides, Kimberly Costas, Paul Kaywin, Miguel Villalona-Calero, Todd Alekshun, Kevin Chen, Suman Rao, and Robert Siegel

Abstract

BACKGROUND Among patients with resectable early-stage non-small-cell lung cancer (NSCLC), a perioperative approach that includes both neoadjuvant and adjuvant immune checkpoint inhibition may provide benefit beyond either approach alone. METHODS We conducted a randomized, double-blind, phase 3 trial to evaluate perioperative pembrolizumab in patients with early-stage NSCLC. Participants with resectable stage II, IIIA, or IIIB (N2 stage) NSCLC were assigned in a 1:1 ratio to receive neoadjuvant pembrolizumab (200 mg) or placebo once every 3 weeks, each of which was given with cisplatin-based chemotherapy for 4 cycles, followed by surgery and adjuvant pembrolizumab (200 mg) or placebo once every 3 weeks for up to 13 cycles. The dual primary end points were event-free survival (the time from randomization to the first occurrence of local progression that precluded the planned surgery, unresectable tumor, progression or recurrence, or death) and overall survival. Secondary end points included major pathological response, pathological complete response, and safety. RESULTS A total of 397 participants were assigned to the pembrolizumab group, and 400 to the placebo group. At the prespecified first interim analysis, the median follow-up was 25.2 months. Event-free survival at 24 months was 62.4% in the pembrolizumab group and 40.6% in the placebo group (hazard ratio for progression, recurrence, or death, 0.58; 95% confidence interval [CI], 0.46 to 0.72; P<0.001). The estimated 24-month overall survival was 80.9% in the pembrolizumab group and 77.6% in the placebo group (P = 0.02, which did not meet the significance criterion). A major pathological response occurred in 30.2% of the participants in the pembrolizumab group and in 11.0% of those in the placebo group (difference, 19.2 percentage points; 95% CI, 13.9 to 24.7; P<0.0001; threshold, P = 0.0001), and a pathological complete response occurred in 18.1% and 4.0%, respectively (difference, 14.2 percentage points

Published
2023

43. Safety and immunogenicity of the PRAME cancer immunotherapeutic in metastatic melanoma: results of a phase I dose escalation study

Author

Gutzmer, R., Rivoltini, L., Levchenko, E., Testori, A., Utikal, J., Ascierto, P.A., Demidov, L., Grob, J.J., Ridolfi, R., Schadendorf, D., Queirolo, P., Santoro, A., Loquai, C., Dreno, B., Hauschild, A., Schultz, E., Lesimple, T.P., Vanhoutte, N., Salaun, B., Gillet, M., Jarnjak, S., De Sousa Alves, P.M., Louahed, J., Brichard, V.G., and Lehmann, F.F.

Published
2016
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44. Assessment of the effectiveness of surgical resections following tyrosine kinase inhibitor therapy in patients with EGFR-mutated stage III–IV lung adenocarcinoma

Author

Levchenko, E. V., primary, Moiseenko, F. V., additional, Orlov, S. V., additional, Imyanitov, E. N., additional, Mikhnin, A. E., additional, Gelfond, M. L., additional, Slugin, E. N., additional, Ergnyan, S. M., additional, Levchenko, N. E., additional, Zhabina, A. S., additional, Ulitin, A. M., additional, Mamontov, O. Yu., additional, Lopushanskaya, O. O., additional, Artemeva, E. V., additional, Murtazin, A. I., additional, and Shabinskaya, V. I., additional

Published
2023
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49. Pembrolizumab plus Concurrent Chemoradiation Therapy (cCRT) for Unresectable, Locally Advanced, Stage III NSCLC: KEYNOTE-799 2-Year Update

Author

Jabbour, S.K., primary, Lee, K.H., additional, Frost, N., additional, Breder, V., additional, Kowalski, D., additional, Levchenko, E., additional, Reguart, N., additional, Martinez-Marti, A., additional, Houghton, B., additional, Paoli, J.B., additional, Safina, S., additional, Komiya, T., additional, Sanford, A., additional, Liu, H., additional, Song, A.J., additional, Keller, S., additional, and Reck, M., additional

Published
2022
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