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Your search keyword '"Levalley, A. J."' showing total 25 results
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25 results on '"Levalley, A. J."'

1. Reversible Mechanical Contraception and Endometriosis Treatment Using Stimuli‐Responsive Hydrogels (Adv. Mater. 23/2024)

Author

Anthis, Alexandre H.C., primary, Kilchenmann, Samuel, additional, Murdeu, Manon, additional, LeValley, Paige J., additional, Wolf, Morris, additional, Meyer, Charlotte, additional, Cipolato, Oscar, additional, Tibbitt, Mark W., additional, Rosendorf, Jachym, additional, Liska, Vaclav, additional, Rduch, Thomas, additional, and Herrmann, Inge K., additional

Published
2024
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2. Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications

Author

LeValley, Paige J, Ovadia, Elisa M, Bresette, Christopher A, Sawicki, Lisa A, Maverakis, Emanual, Bai, Shi, and Kloxin, April M

Subjects
Engineering, Organic Chemistry, Chemical Sciences, Biomedical Engineering, Biotechnology, Chemical sciences
Abstract

An approach for the design of functionalized cyclic peptides is established for use in 3D cell culture and in cell targeting. Sequential orthogonal click reactions, specifically a photoinitiated thiol-ene and strain promoted azide-alkyne cycloaddition, were utilized for peptide cyclization and conjugation relevant for biomaterial and biomedical applications, respectively.

Published
2018

3. Controlling the Release of Small, Bioactive Proteins via Dual Mechanisms with Therapeutic Potential

Author

Kharkar, Prathamesh M, Scott, Rebecca A, Olney, Laura P, LeValley, Paige J, Maverakis, Emanual, Kiick, Kristi L, and Kloxin, April M

Subjects
Engineering, Biomedical Engineering, Bioengineering, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Adventitia, Cells, Cultured, Delayed-Action Preparations, Fibroblast Growth Factor 2, Fibroblasts, Glutathione, Heparin, Humans, Hydrogels, Male, Maleimides, Middle Aged, Molecular Weight, Polyethylene Glycols, Polymers, Proteins, biologics delivery, controlled release, injectable hydrogel, responsive materials, Medicinal and Biomolecular Chemistry, Medical Biotechnology, Medical biotechnology, Biomedical engineering
Abstract

Injectable delivery systems that respond to biologically relevant stimuli present an attractive strategy for tailorable drug release. Here, the design and synthesis of unique polymers are reported for the creation of hydrogels that are formed in situ and degrade in response to clinically relevant endogenous and exogenous stimuli, specifically reducing microenvironments and externally applied light. Hydrogels are formed with polyethylene glycol and heparin-based polymers using a Michael-type addition reaction. The resulting hydrogels are investigated for the local controlled release of low molecular weight proteins (e.g., growth factors and cytokines), which are of interest for regulating various cellular functions and fates in vivo yet remain difficult to deliver. Incorporation of reduction-sensitive linkages and light-degradable linkages affords significant changes in the release profiles of fibroblast growth factor-2 (FGF-2) in the presence of the reducing agent glutathione or light, respectively. The bioactivity of the released FGF-2 is comparable to pristine FGF-2, indicating the ability of these hydrogels to retain the bioactivity of cargo molecules during encapsulation and release. Further, in vivo studies demonstrate degradation-mediated release of FGF-2. Overall, our studies demonstrate the potential of these unique stimuli-responsive chemistries for controlling the local release of low molecular weight proteins in response to clinically relevant stimuli.

Published
2017

5. Cell Therapy Biomanufacturing: Integrating Biomaterial and Flow‐Based Membrane Technologies for Production of Engineered T‐Cells

Author

Bomb, Kartik, primary, LeValley, Paige J., additional, Woodward, Ian R., additional, Cassel, Samantha E., additional, Sutherland, Bryan P., additional, Bhattacharjee, Arnab, additional, Yun, Zaining, additional, Steen, Jonathan, additional, Kurdzo, Emily, additional, McCoskey, Jacob, additional, Burris, David, additional, Levine, Kara, additional, Carbrello, Christina, additional, Lenhoff, Abraham M., additional, Fromen, Catherine A., additional, and Kloxin, April M., additional

Published
2023
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