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1. Banach lattices with upper p-estimates: free and injective objects

Author: García-Sánchez, E., Leung, D. H., Taylor, M. A., and Tradacete, P.
Published: 2024
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2. Banach lattices with upper $p$-estimates: free and injective objects

Author: García-Sánchez, E., Leung, D. H., Taylor, M. A., and Tradacete, P.
Subjects: Mathematics - Functional Analysis, 46B42, 06B25, 47B60
Abstract: We study the free Banach lattice $FBL^{(p,\infty)}[E]$ with upper $p$-estimates generated by a Banach space $E$. Using a classical result of Pisier on factorization through $L^{p,\infty}(\mu)$ together with a finite dimensional reduction, it is shown that the spaces $\ell^{p,\infty}(n)$ witness the universal property of $FBL^{(p,\infty)}[E]$ isomorphically. As a consequence, we obtain a functional representation for $FBL^{(p,\infty)}[E]$. More generally, our proof allows us to identify the norm of any free Banach lattice over $E$ associated with a rearrangement invariant function space. After obtaining the above functional representation, we take the first steps towards analyzing the fine structure of $FBL^{(p,\infty)}[E]$. Notably, we prove that the norm for $FBL^{(p,\infty)}[E]$ cannot be isometrically witnessed by $L^{p,\infty}(\mu)$ and settle the question of characterizing when an embedding between Banach spaces extends to a lattice embedding between the corresponding free Banach lattices with upper $p$-estimates. To prove this latter result, we introduce a novel push-out argument, which when combined with the injectivity of $\ell^p$ allows us to give an alternative proof of the subspace problem for free $p$-convex Banach lattices. On the other hand, we prove that $\ell^{p,\infty}$ is not injective in the class of Banach lattices with upper $p$-estimates, elucidating one of many difficulties arising in the study of $FBL^{(p,\infty)}[E]$., Comment: 37 pages
Published: 2024

3. Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

Author: Marchal, A, Cirulli, E, Neveux, I, Bellos, E, Thwaites, R, Schiabor Barrett, K, Zhang, Y, Nemes-Bokun, I, Kalinova, M, Catchpole, A, Tangye, S, Spaan, A, Lack, J, Ghosn, J, Burdet, C, Gorochov, G, Tubach, F, Hausfater, P, Abel, L, Aiuti, A, Al-Muhsen, S, Al-Mulla, F, Amara, A, Anderson, M, Andreakos, E, Arias, A, Arkin, L, Feldman, H, Bastard, P, Belot, A, Biggs, C, Bogunovic, D, Bolze, A, Bondarenko, A, Borghesi, A, Bousfiha, A, Brodin, P, Bryceson, Y, Butte, M, Casanova, J, Casari, G, Christodoulou, J, Cobat, A, Colobran, R, Condino-Neto, A, Constantinescu, S, Cooper, M, Dalgard, C, Desai, M, Drolet, B, Duval, X, El Baghdadi, J, Eloy, P, Espinosa-Padilla, S, Fellay, J, Flores, C, Franco, J, Froidure, A, Gregersen, P, Grimbacher, B, Haerynck, F, Hagin, D, Halwani, R, Hammarstrom, L, Heath, J, Hsieh, E, Husebye, E, Imai, K, Itan, Y, Jouanguy, E, Kaja, E, Karamitros, T, Kisand, K, Ku, C, Lau, Y, Ling, Y, Lucas, C, Maniatis, T, Mansouri, D, Marodi, L, Mentre, F, Meyts, I, Milner, J, Mironska, K, Mogensen, T, Morio, T, Ng, L, Notarangelo, L, Novelli, A, Novelli, G, O'Farrelly, C, Okada, S, Okamoto, K, Ozcelik, T, Pan-Hammarstrom, Q, Pape, J, Perez de Diego, R, Perez-Tur, J, Perlin, D, Pesole, G, Planas, A, Prando, C, Pujol, A, Puel, A, Quintana-Murci, L, Ramaswamy, S, Renia, L, Resnick, I, Rodriguez-Gallego, C, Sancho-Shimizu, V, Sediva, A, Seppanen, M, Shahrooei, M, Shcherbina, A, Slaby, O, Snow, A, Soler-Palacin, P, Soumelis, V, Tancevski, I, Tayoun, A, Temel, S, Thorball, C, Tiberghien, P, Trouillet-Assant, S, Turvey, S, Uddin, K, Uddin, M, van de Beek, D, Vinh, D, von Bernuth, H, Wauters, J, Zatz, M, Zawadzki, P, Zhang, Q, Zhang, S, Bureau, S, Vacher, Y, Gysembergh-Houal, A, Demerville, L, Benleulmi-Chaachoua, A, Abad, S, Abassi, R, Abdellaoui, A, Abdelmalek, A, Abdoul, H, Abergel, H, Abeud, F, Abgrall, S, Abisror, N, Adechian, M, Aderdour, N, Admane, H, Adnet, F, Afritt, S, Agostini, H, Aguilar, C, Agut, S, Aiello, T, Kaci, M, Oufella, H, Ajeenthiravasan, G, Alauzy, V, Alby-Laurent, F, Allard, L, Alyanakian, M, Borrero, B, Amam, S, Amrouche, L, Andronikof, M, Anglicheau, D, Anguel, N, Annane, D, Aounzou, M, Aparicio, C, Aratus, G, Arlet, J, Arzoine, J, Aslangul, E, Assefi, M, Aubry, A, Audiffred, L, Audureau, E, Auger, C, Auregan, J, Awotar, C, Milla, S, Azan, D, Azemar, L, Azzouguen, B, Elrufaai, M, Badsi, A, Bakouboula, P, Balcerowiak, C, Balde, F, Baldivia, E, Bangamingo, E, Baptiste, A, Baran-Marszak, F, Barau, C, Barget, N, Baronnet, F, Barthelemy, R, Baudel, J, Baudry, C, Baudry, E, Beaugerie, L, Belamri, A, Belaube, N, Belilita, R, Bellassen, P, Belmokhtar, R, Beltran, I, Benainous, R, Benallaoua, M, Benamouzig, R, Benbara, A, Benhida, J, Benkhelouf, A, Benlagha, J, Benmostafa, C, Benothmane, S, Bentifraouine, M, Berard, L, Bernier, Q, Berti, E, Bertier, A, Berton, L, Bessis, S, Beurton, A, Bianco, C, Bianquis, C, Bidar, F, Blanche, P, Blayau, C, Bleibtreu, A, Blin, E, Bloch-Queyrat, C, Boissier, M, Bollens, D, Bolzoni, M, Bompard, R, Bonnet, N, Bonnouvrier, J, Botha, S, Boucenna, W, Bouchama, F, Bouchaud, O, Bouchghoul, H, Boudjebla, T, Boudjema, N, Bouffard, C, Bougle, A, Bouguerra, M, Bouras, L, Bourcier, A, Durand, A, Bourrier, A, Bouscarat, F, Bouvry, D, Bouziri, N, Bouzrara, O, Bribier, S, Brugier, D, Brunel, M, Bui, E, Buisson, A, Bukreyeva, I, Bureau, C, Cadranel, J, Cailhol, J, Calin, R, Vega, C, Canavaggio, P, Cancella, M, Cantin, D, Cao, A, Carbillon, L, Carlier, N, Cassard, C, Castor, G, Cauchy, M, Cha, O, Chaigne, B, Challal, S, Champion, K, Chariot, P, Chas, J, Chauveau, S, Chauvin, A, Chauvin, C, Chavarot, N, Chebbout, K, Cherai, M, Cherubini, I, Chevalier, A, Chiarabini, T, Chinet, T, Chocron, R, Choinier, P, Chommeloux, J, Choquet, C, Choupeaux, L, Chousterman, B, Ciocan, D, Clarke, A, Clavere, G, Clavier, F, Clement, K, Clerc, S, Cohen, Y, Cohen, F, Cohen, A, Coilly, A, Colboc, H, Colin, P, Collet, M, Comarmond, C, Combacon, E, Combes, A, Comparon, C, Constantin, J, Cordel, H, Cordier, A, Costantini, A, Chalumeau, N, Couffignal, C, Coupeau, D, Creange, A, Lamarre, Y, Da Silveira, C, Guibal El Kayani, S, De Castro, N, De Rycke, Y, Del Pozo, L, Delannoy, Q, Delay, M, Deleris, R, Delforge, J, Delphine, L, Demare, N, Demeret, S, Demoule, A, Deniau, A, Depret, F, Derolez, S, Derradji, O, Derridj, N, Descamps, V, Deschamps, L, Desconclois, C, Desnos, C, Desongins, K, Dhote, R, Diallo, B, Didier, M, Diemer, M, Diez, S, Djadi-Prat, J, Djamouri Monnory, F, Djebara, S, Djebra, N, Djietcheu, M, Djillali, H, Djouadi, N, Donneger, S, Santos, C, Dournon, N, Dres, M, Droctove, L, Drogrey, M, Dropy, M, Drouet, E, Dubosq, V, Dubreucq, E, Dubus, E, Duchemann, B, Duchenoy, T, Dudoignon, E, Dufau, R, Dumas, F, Duran, C, Duron, E, Durrbach, A, Duvivier, C, Ebstein, N, El Khalifa, J, Elabbadi, A, Elie, C, Ernotte, G, Esling, A, Etienne, M, Eyer, X, Fartoukh, M, Fayali, T, Fermaut, M, Fiorentino, A, Fliss, S, Fournier, M, Fournier, B, Francois, H, Freynet, O, Frigout, Y, Fromont, I, Fuentes, A, Furet, T, Galand, J, Garnier, M, Gaubert, A, Gaudry, S, Gaugain, S, Gauthier, D, Gautier, M, Georgin-Lavialle, S, Geromin, D, Ghalayini, M, Ghaleh, B, Ghezal, M, Gibelin, A, Gimeno, L, Girard, B, Leprieur, B, Gomes, D, Gomes-Pires, E, Gouge, A, Gouja, A, Goulet, H, Goupil, S, De Bouille, J, Gras, J, Greffe, S, Grimaldi, L, Guedeney, P, Guidet, B, Guillo, M, Gulczynski, M, Hadjam, T, Haguenauer, D, Hammal, S, Hammoudi, N, Hanon, O, Harrois, A, Hautem, C, Hekimian, G, Heming, N, Hermine, O, Ho, S, Houllier, M, Huot, B, Huscenot, T, Saied, W, Ikherbane, G, Imarazene, M, Ingiliz, P, Iratni, L, Jaureguiberry, S, Jean-Marc, J, Jeyarajasingham, D, Jouany, P, Jouis, V, Jourdaine, C, Kafif, O, Kallala, R, Katsahian, S, Kelesyan, L, Keo, V, Ketz, F, Khamis, W, Khelili, E, Khellaf, M, Kotokpo Youkou, C, Kounis, I, Kpalma, G, Krause, J, Labbe, V, Lacombe, K, Lacorte, J, Lafont, A, Lafont, E, Lagha, L, Lamhaut, L, Lancelot, A, Landman, C, Lanternier, F, Larcheveque, C, Combe, C, Lassel, L, Laverdant, B, Lavergne, C, Lavillegrand, J, Lazureanu, P, Le Guennec, L, Leberre, L, Leblanc, C, Leboyer, M, Lecomte, F, Lecorre, M, Leenhardt, R, Lefebvre, M, Lefebvre, B, Legendre, P, Leger, A, Legros, L, Legrosse, J, Lehuunghia, S, Lemarec, J, Leporrier-Ext, J, Lesein, M, Lesur, H, Levy, V, Levy, A, Lopes, E, Lopes, A, Lopez, V, Lopinto, J, Lortholary, O, Louadah, B, Loze, B, Lucas, M, Lucasamichi, A, Luong, L, Magazimama-Ext, A, Maingret, D, Mameri, L, Manivet, P, Mansouri, C, Marcault, E, Marey, J, Marin, N, Marois, C, Martin, O, Martineau, L, Martinez-Lopez, C, Martyniuck, P, De Farcy, P, Marzouk, N, Masmoudi, R, Mebazaa, A, Mechai, F, Mecozzi, F, Mediouni, C, Megarbane, B, Meghadecha, M, Mejean, E, Mekinian, A, Abdelhadi, N, Mekni, R, Meliti, T, Lima, B, Meng, P, Merbah, S, Messani, F, Messaoudi, Y, Mewasing, B, Meziane, L, Michelot-Burger, C, Mignot, F, Minka, F, Miyara, M, Moine, P, Molina, J, Montegnies-Boulet, A, Monti, A, Montlahuc, C, Montout, A, Moores, A, Morbieu, C, Mortelette, H, Mouly, S, Muzaffar, R, Nacerddine, C, Nadal, M, Nadif, H, Nassarmadji, K, Natella, P, Ndingamondze, S, Neraal, S, Nguyen, C, N'Guyen, B, Larmurier, I, Nlomenyengue, L, Noel, N, Nunes, H, Omar, E, Ouazene, Z, Ouedraogo, E, Ouelaa, W, Oukhedouma, A, Amara, Y, Oya, H, Oziel, J, Padilla, T, Paillaud, E, Paiva, S, Parfait, B, Parize, P, Parizot, C, Parrot, A, Pavot, A, Peaudecerf, L, Pene, F, Pepin, M, Pernet, J, Pernin, C, Petit, M, Peyrony, O, Pietri, M, Pietri, O, De Chambrun, M, Pinson, M, Pintado, C, Piquard, V, Pires, C, Planquette, B, Poirier, S, Pomel, A, Pons, S, Ponscarme, D, Pourcelot, A, Pourcher, V, Pouvaret, A, Prever, F, Previlon, M, Prevost, M, Provoost, M, Quemeneur, C, Rafat, C, Rami, A, Ranque, B, Raphael, M, Raphalen, J, Rastoin, A, Raux, M, Rebai, A, Reby, M, Regent, A, Regrag, A, Resche-Rigon, M, Ressaire, Q, Richard, C, Richard, M, Robert, M, Rohaut, B, Rolland-Debord, C, Ropers, J, Roque-Afonso, A, Rosso, C, Rousseaux, M, Rousseaux, N, Roux, S, Roux, L, Rouzaud, C, Rozes, A, Rubenstein, E, Sabate, J, Sabet, S, Sacleux, S, Kermanach, N, Saliba, F, Salmon, D, Savale, L, Savary, G, Sberro, R, Scemla, A, Schlemmer, F, Schwartz, M, Sedfi, S, Sefir-Kribel, S, Seksik, P, Sellier, P, Selves, A, Sembach, N, Semerano, L, Senat, M, Sene, D, Serris, A, Sese, L, Sghiouar, N, Sigaux, J, Siguier, M, Silvain, J, Simon, N, Simon, T, Skandri, L, Slimani, M, Snauwaert, A, Sokol, H, Soliman, H, Soltani, N, Soyer, B, Steg, G, Suarez, L, Szwebel, T, Taffame, K, Tandjaoui-Lambiotte, Y, Tantet, C, Tateo, M, Theodose, I, Thiebaud, P, Thomas, C, Tiercelet, K, Tisserand, J, Tomczak, C, Torelino, K, Touam-Ext, F, Toumi, L, Toury, G, Toy-Miou, M, Dinh Thanh Lien, O, Trandinh, A, Treluyer, J, Trinque, B, Truchot, J, Tubiana, S, Tunesi, S, Turpin, M, Turpin, A, Urbina, T, Narvaez, R, Uzunhan, Y, Vaittinadaayar, P, Valent, A, Valentian, M, Valin, N, Vallet, H, Vaz, M, Vazquezibarra, M, Vedie, B, Velly, L, Verstuyft, C, Viallette, C, Vicaut, E, Vignes, D, Vimpere, D, Virlouvet, M, Voiriot, G, Voisot, L, Weiss, E, Weiss, N, Winchenne, A, Yordanov, Y, Zafrani, L, Zaidan, M, Zaidi, W, Zak, C, Zarhrate-Ghoul, A, Zatout, O, Zeino, S, Zeitouni, M, Zemirli, N, Zerah, L, Zia, O, Ziol, M, Zolario, O, Zuber, J, Andrejak, C, Angoulvant, F, Bachelet, D, Bartoli, M, Basmaci, R, Behillil, S, Beluze, M, Benkerrou, D, Bhavsar, K, Bouadma, L, Bouchez, S, Bouscambert, M, Cervantes-Gonzalez, M, Chair, A, Chirouze, C, Coelho, A, Couffin-Cadiergues, S, D'Ortenzio, E, Debray, M, Deconinck, L, Deplanque, D, Descamps, D, Desvallee, M, Diallo, A, Diouf, A, Dorival, C, Dubos, F, Elharrar, B, Enouf, V, Esperou, H, Esposito-Farese, M, Devouge, E, Gault, N, Gaymard, A, Gigante, T, Gilg, M, Guedj, J, Hoctin, A, Hoffmann, I, Houas, I, Hulot, J, Jaafoura, S, Kaguelidou, F, Kali, S, Khalil, A, Khan, C, Laouenan, C, Laribi, S, Le, M, Le Hingrat, Q, Le Mestre, S, Le Nagard, H, Lescure, F, Letrou, S, Levy, Y, Lina, B, Lingas, G, Lucet, J, Malvy, D, Mambert, M, Meziane, A, Mouquet, H, Mullaert, J, Neant, N, Nguyen, D, Noret, M, Nseir, S, Papadopoulos, A, Paul, C, Peiffer-Smadja, N, Perpoint, T, Petrov-Sanchez, V, Peytavin, G, Pham, H, Picone, O, Puechal, O, Rabaud, C, Rosa-Calatrava, M, Rossignol, B, Rossignol, P, Roy, C, Schneider, M, Su, R, Tardivon, C, Tellier, M, Teoule, F, Terrier, O, Timsit, J, Tual, C, van der Werf, S, Vanel, N, Veislinger, A, Visseaux, B, Wiedemann, A, Yazdanpanah, Y, Alavoine, L, Charpentier, C, Dechanet, A, Ecobichon, J, Frezouls, W, Houhou, N, Lehacaut, J, Manchon, P, Nouroudine, M, Quintin, C, Thy, M, Vignali, V, Chahine, A, Waucquier, N, Migaud, M, Djossou, F, Mergeay-Fabre, M, Lucarelli, A, Demar, M, Bruneau, L, Gerardin, P, Maillot, A, Payet, C, Laviolle, B, Laine, F, Paris, C, Desille-Dugast, M, Fouchard, J, Pistone, T, Perreau, P, Gissot, V, Goas, C, Montagne, S, Richard, L, Bouiller, K, Desmarets, M, Meunier, A, Bourgeon, M, Lefevre, B, Jeulin, H, Legrand, K, Lomazzi, S, Tardy, B, Gagneux-Brunon, A, Bertholon, F, Botelho-Nevers, E, Kouakam, C, Nicolas, L, Roufai, L, Amat, K, Hendou, S, Foti, G, Citerio, G, Contro, E, Pesci, A, Valsecchi, M, Cazzaniga, M, Bellani, G, Abad, J, Accordino, G, Angelini, M, Aguilera-Albesa, S, Aguilo-Cucurull, A, Ozkan, E, Darazam, I, Roblero Albisures, J, Aldave, J, Ramos, M, Khan, T, Aliberti, A, Nadji, S, Alkan, G, Alkhater, S, Allardet-Servent, J, Allende, L, Alonso-Arias, R, Alshahrani, M, Alsina, L, Amoura, Z, Antoli, A, Arrestier, R, Aubart, M, Auguet, T, Avramenko, I, Aytekin, G, Azot, A, Bahram, S, Bajolle, F, Baldanti, F, Baldolli, A, Ballester, M, Barrou, B, Barzaghi, F, Basso, S, Bayhan, G, Bezrodnik, L, Bilbao, A, Blanchard-Rohner, G, Blanco, I, Blandinieres, A, Blazquez-Gamero, D, Bloomfield, M, Bolivar-Prados, M, Borie, R, Botdhlo-Nevers, E, Bousquet, A, Boutolleau, D, Bouvattier, C, Boyarchuk, O, Bravais, J, Briones, M, Brunner, M, Bruno, R, Bueno, M, Bukhari, H, Bustamante, J, Caceres Agra, J, Capra, R, Carapito, R, Carrabba, M, Casasnovas, C, Caseris, M, Cassaniti, I, Castelle, M, Castelli, F, Castillo de Vera, M, Castro, M, Catherinot, E, Celik, J, Ceschi, A, Chalumeau, M, Charbit, B, Boulanger, C, Clave, P, Clotet, B, Codina, A, Comoli, P, Corsico, A, Coskuner, T, Cvetkovski, A, Cyrus, C, Dalmau, D, Danion, F, Darley, D, Das, V, Dauby, N, Dauger, S, De Munte, P, de Pontual, L, Dehban, A, Delplancq, G, Desguerre, I, Di Sabatino, A, Diehl, J, Dobbelaere, S, Dominguez-Garrido, E, Dubost, C, Ekwall, O, Bozdemir, S, Elnagdy, M, Emiroglu, M, Endo, A, Erdeniz, E, Aytekin, S, Etxart Lasa, M, Euvrard, R, Fabio, G, Faivre, L, Falck, A, Faure, M, Arquero, M, Ferrer, R, Ferreres, J, Francois, B, Fumado, V, Fung, K, Fusco, F, Gagro, A, Solis, B, Garcon, P, Gaussem, P, Gayretli, Z, Gil-Herrera, J, Gilardin, L, Gatineau, A, Girona-Alarcon, M, Cifuentes Godinez, K, Goffard, J, Gonzales, N, Gonzalez-Granado, L, Gonzalez-Montelongo, R, Guerder, A, Gulhan, B, Gumucio, V, Hanitsch, L, Gunst, J, Gut, M, Hadjadj, J, Hancerli, S, Hariyan, T, Hatipoglu, N, Heppekcan, D, Hernandez-Brito, E, Ho, P, Holanda-Pena, M, Horcajada, J, Hraiech, S, Humbert, L, Hung, I, Iglesias, A, Inigo-Campos, A, Jamme, M, Arranz, M, Jimeno, M, Jordan, I, Kanik-Yuksek, S, Kara, Y, Karahan, A, Karbuz, A, Yasar, K, Kasapcopur, O, Kashimada, K, Keles, S, Demirkol, Y, Kido, Y, Kizil, C, Kilic, A, Klocperk, A, Koutsoukou, A, Krol, Z, Ksouri, H, Kuentz, P, Kwan, A, Kwan, Y, Kwok, J, Lagier, J, Lam, D, Lampropoulou, V, Le Bourgeois, F, Leo, Y, Lopez, R, Leung, D, Levin, M, Levy, M, Levy, R, Li, Z, Lilleri, D, Adrian Bolanos Lima, E, Linglart, A, Lopez-Collazo, E, Lorenzo-Salazar, J, Louapre, C, Lubetzki, C, Lung, K, Luyt, C, Lye, D, Magnone, C, Marchioni, E, Marioli, C, Marjani, M, Marques, L, Pereira, J, Martin-Nalda, A, Pueyo, D, Martinez-Picado, J, Marzana, I, Mata-Martinez, C, Mathian, A, Matos, L, Matthews, G, Mayaux, J, McLaughlin-Garcia, R, Meersseman, P, Mege, J, Mekontso-Dessap, A, Melki, I, Meloni, F, Meritet, J, Merlani, P, Akcan, O, Mezidi, M, Migeotte, I, Millereux, 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U., Uzunhan Y., Vaittinadaayar P., Valent A., Valentian M., Valin N., Vallet H., Vaz M., Vazquezibarra M. -A., Vedie B., Velly L., Verstuyft C., Viallette C., Vicaut E., Vignes D., Vimpere D., Virlouvet M., Voiriot G., Voisot L., Weiss E., Weiss N., Winchenne A., Yordanov Y., Zafrani L., Zaidan M., Zaidi W., Zak C., Zarhrate-Ghoul A., Zatout O., Zeino S., Zeitouni M., Zemirli N., Zerah L., Zia O., Ziol M., Zolario O., Zuber J., Andrejak C., Angoulvant F., Bachelet D., Bartoli M., Basmaci R., Behillil S., Beluze M., Benkerrou D., Bhavsar K., Bouadma L., Bouchez S., Bouscambert M., Cervantes-Gonzalez M., Chair A., Chirouze C., Coelho A., Couffin-Cadiergues S., d'Ortenzio E., Debray M. -P., Deconinck L., Deplanque D., Descamps D., Desvallee M., Diallo A., Diouf A., Dorival C., Dubos F., Elharrar B., Enouf V., Esperou H., Esposito-Farese M., Devouge E. F., Gault N., Gaymard A., Gigante T., Gilg M., Guedj J., Hoctin A., Hoffmann I., Houas I., Hulot J. -S., Jaafoura S., Kaguelidou F., Kali S., Khalil A., Khan C., Laouenan C., Laribi S., Le M., Le Hingrat Q., Le Mestre S., Le Nagard H., Lescure F. -X., Letrou S., Levy Y., Lina B., Lingas G., Lucet J. -C., Malvy D., Mambert M., Meziane A., Mouquet H., Mullaert J., Neant N., Nguyen D., Noret M., Nseir S., Papadopoulos A., Paul C., Peiffer-Smadja N., Perpoint T., Petrov-Sanchez V., Peytavin G., Pham H., Picone O., Puechal O., Rabaud C., Rosa-Calatrava M., Rossignol B., Rossignol P., Roy C., Schneider M., Su R., Tardivon C., Tellier M. -C., Teoule F., Terrier O., Timsit J. -F., Tual C., van der Werf S., Vanel N., Veislinger A., Visseaux B., Wiedemann A., Yazdanpanah Y., Alavoine L., Charpentier C., Dechanet A., Ecobichon J. -L., Frezouls W., Houhou N., Lehacaut J., Manchon P., Nouroudine M., Quintin C., Thy M., Vignali V., Chahine A., Waucquier N., Migaud M. -C., Djossou F., Mergeay-Fabre M., Lucarelli A., Demar M., Bruneau L., Gerardin P., Maillot A., Payet C., Laviolle B., Laine F., Paris C., Desille-Dugast M., Fouchard J., Pistone T., Perreau P., Gissot V., Goas C. L. E., Montagne S., Richard L., Bouiller K., Desmarets M., Meunier A., Bourgeon M., Lefevre B., Jeulin H., Legrand K., Lomazzi S., Tardy B., Gagneux-Brunon A., Bertholon F., Botelho-Nevers E., Kouakam C., Nicolas L., Roufai L., Amat K., Hendou S., Foti G., Citerio G., Contro E., Pesci A., Valsecchi M. G., Cazzaniga M., Bellani G., Abad J., Accordino G., Angelini M., Aguilera-Albesa S., Aguilo-Cucurull A., Ozkan E. A., Darazam I. A., Roblero Albisures J. A., Aldave J. C., Ramos M. A., Khan T. A., Aliberti A., Nadji S. A., Alkan G., AlKhater S. A., Allardet-Servent J., Allende L. M., Alonso-Arias R., Alshahrani M. S., Alsina L., Amoura Z., Antoli A., Arrestier R., Aubart M., Auguet T., Avramenko I., Aytekin G., Azot A., Bahram S., Bajolle F., Baldanti F., Baldolli A., Ballester M., Barrou B., Barzaghi F., Basso S., Bayhan G. I., Bezrodnik L., Bilbao A., Blanchard-Rohner G., Blanco I., Blandinieres A., Blazquez-Gamero D., Bloomfield M., Bolivar-Prados M., Borie R., Botdhlo-Nevers E., Bousquet A., Boutolleau D., Bouvattier C., Boyarchuk O., Bravais J., Briones M. L., Brunner M. -E., Bruno R., Bueno M. R. P., Bukhari H., Bustamante J., Caceres Agra J. J., Capra R., Carapito R., Carrabba M., Casasnovas C., Caseris M., Cassaniti I., Castelle M., Castelli F., Castillo de Vera M., Castro M. V., Catherinot E., Celik J. B., Ceschi A., Chalumeau M., Charbit B., Boulanger C., Clave P., Clotet B., Codina A., Comoli P., Corsico A. G., Coskuner T., Cvetkovski A., Cyrus C., Dalmau D., Danion F., Darley D. R., Das V., Dauby N., Dauger S., De Munte P., de Pontual L., Dehban A., Delplancq G., Desguerre I., Di Sabatino A., Diehl J. -L., Dobbelaere S., Dominguez-Garrido E., Dubost C., Ekwall O., Bozdemir S. E., Elnagdy M. H., Emiroglu M., Endo A., Erdeniz E. H., Aytekin S. E., Etxart Lasa M. P., Euvrard R., Fabio G., Faivre L., Falck A., Fartoukh M., Faure M., Arquero M. F., Ferrer R., Ferreres J., Francois B., Fumado V., Fung K. S. C., Fusco F., Gagro A., Solis B. G., Garcon P., Gaussem P., Gayretli Z., Gil-Herrera J., Gilardin L., Gatineau A. G., Girona-Alarcon M., Cifuentes Godinez K. A., Goffard J. -C., Gonzales N., Gonzalez-Granado L. I., Gonzalez-Montelongo R., Guerder A., Gulhan B., Gumucio V. D., Hanitsch L. G., Gunst J., Gut M., Hadjadj J., Hancerli S., Hariyan T., Hatipoglu N., Heppekcan D., Hernandez-Brito E., Ho P. -K., Holanda-Pena M. S., Horcajada J. P., Hraiech S., Humbert L., Hung I. F. N., Iglesias A. D., Inigo-Campos A., Jamme M., Arranz M. J., Jimeno M. -T., Jordan I., Kanik-Yuksek S., Kara Y., Karahan A., Karbuz A., Yasar K. K., Kasapcopur O., Kashimada K., Keles S., Demirkol Y. K., Kido Y., Kizil C., Kilic A. O., Klocperk A., Koutsoukou A., Krol Z. J., Ksouri H., Kuentz P., Kwan A. M. C., Kwan Y. W. M., Kwok J. S. Y., Lagier J. -C., Lam D. S. Y., Lampropoulou V., Le Bourgeois F., Leo Y. -S., Lopez R. L., Leung D., Levin M., Levy M., Levy R., Li Z., Lilleri D., Adrian Bolanos Lima E. J., Linglart A., Lopez-Collazo E., Lorenzo-Salazar J. M., Louapre C., Lubetzki C., Lung K. -C., Luyt C. -E., Lye D. C., Magnone C., Marchioni E., Marioli C., Marjani M., Marques L., Pereira J. M., Martin-Nalda A., Pueyo D. M., Martinez-Picado J., Marzana I., Mata-Martinez C., Mathian A., Matos L. R. B., Matthews G. V., Mayaux J., McLaughlin-Garcia R., Meersseman P., Mege J. -L., Mekontso-Dessap A., Melki I., Meloni F., Meritet J. -F., Merlani P., Akcan O. M., Mezidi M., Migeotte I., Millereux M., Million M., Mirault T., Mircher C., Mirsaeidi M., Mizoguchi Y., Modi B. P., Mojoli F., Moncomble E., Melian A. M., Martinez A. M., Morandeira F., Morange P. -E., Mordacq C., Morelle G., Mouly S. J., Munoz-Barrera A., Nafati C., Nagashima S., Nakagama Y., Neven B., Neves J. F., Ng Y. -Y., Hubert Nielly, Medina Y. N., Cuadros E. N., Karabela S. N., Ocejo-Vinyals J. G., Oualha M., Ouedrani A., Ozkaya-Parlakay A., Pagani M., Papadaki M., Parola P., Pascreau T., Paul S., Paz-Artal E., Pedraza S., Gonzalez Pellecer N. C., Pellegrini S., Perez-Fernandez X. L., Philippe A., Philippot Q., Picod A., Pineton de Chambrun M., Piralla A., Planas-Serra L., Ploin D., Poissy J., Poncelet G., Poulakou G., Pouletty M. S., Pourshahnazari P., Qiu-Chen J. L., Quentric P., Rambaud T., Raoult D., Raoult V., Rebillat A. -S., Redin C., Resmini L., Ricart P., Richard J. -C., Rigo-Bonnin R., Rivet N., Riviere J. G., Rocamora-Blanch G., Rodero M. P., Rodrigo C., Rodriguez L. A., Rodriguez-Palmero A., Romero C. S., Rothenbuhler A., Roux D., Rovina N., Rozenberg F., Ruch Y., Ruiz M., Ruiz del Prado M. Y., Ruiz-Rodriguez J. C., Sabater-Riera J., Saks K., Salagianni M., Sanchez O., Sanchez-Montalva A., Sanchez-Ramon S., Schidlowski L., Schluter A., Schmidt J., Schmidt M., Schuetz C., Schweitzer C. E., Scolari F., Seijo L., Seminario A. G., Seng P., Senoglu S., Seppanen M., Llovich A. S., Siguret V., Siouti E., Smadja D. M., Smith N., Sobh A., Solanich X., Sole-Violan J., Soler C., Sozeri B., Stella G. M., Stepanovskiy Y., Stoclin A., Taccone F., Taupin J. -L., Tavernier S. J., Tello L. V., Terrier B., Thiery G., Thorn K., Thumerelle C., Tipu I., Tolstrup M., Tomasoni G., Toubiana J., Alvarez J. T., Triantafyllia V., Troya J., Tsang O. T. Y., Tserel L., Tso E. Y. K., Tucci A., Tuter Oz S. K., Ursini M. V., Utsumi T., Vabres P., Valencia-Ramos J., Van Den Rym A. M., Vandernoot I., Velez-Santamaria V., Zuniga Veliz S. P., Vidigal M. C., Viel S., Villain C., Vilaire-Meunier M. E., Villar-Garcia J., Vincent A., Van der Linden D., Volokha A., Vuotto F., Wauters E., Wu A. K. L., Wu T. -C., Yahsi A., Yesilbas O., Yildiz M., Young B. E., Yukselmis U., Zecca M., Zuccaro V., Van Praet J., Lambrecht B. N., Van Braeckel E., Bosteels C., Hoste L., Hoste E., Bauters F., De Clercq J., Heijmans C., Slabbynck H., Naesens L., Florkin B., Young M. -A., Willis A., Lapuente-Suanzes P., de Andres-Martin A., Berkell M., Carelli V., Malhotra S., Mattiaccio A., Pippucci T., Seri M., Tacconelli E., van Agtmael M., Algera A. G., Appelman B., van Baarle F., Bax D., Beudel M., Bogaard H. J., Bomers M., Bonta P., Bos L., Botta M., de Brabander J., de Bree G., de Bruin S., Buis D. T. P., Bugiani M., Bulle E., Chouchane O., Cloherty A., Dijkstra M., Dongelmans D. A., Dujardin R. W. G., Elbers P., Fleuren L., Geerlings S., Geijtenbeek T., Girbes A., Goorhuis B., Grobusch M. P., Hafkamp F., Hagens L., Hamann J., Harris V., Hemke R., Hermans S. M., Heunks L., Hollmann M., Horn J., Hovius J. W., de Jong M. D., Koning R., Lim E. H. T., van Mourik N., Nellen J., Nossent E. J., Paulus F., Peters E., Pina-Fuentes D. A. I., van der Poll T., Preckel B., Prins J. M., Raasveld J., Reijnders T., de Rotte M. C. F. J., Schinkel M., Schultz M. J., Schrauwen F. A. P., Schuurmans A., Schuurmans J., Sigaloff K., Slim M. A., Smeele P., Smit M., Stijnis C. S., Stilma W., Teunissen C., Thoral P., Tsonas A. M., Tuinman P. R., van der Valk M., Veelo D. P., Volleman C., de Vries H., Vught L. A., van Vugt M., Wouters D., Zwinderman A. H., Brouwer M. C., Wiersinga W. J., Vlaar A. P. J., Tompkins M. F., Alba C., Hupalo D. N., Rosenberger J., Sukumar G., Wilkerson M. D., Zhang X., Lack J., Oler A. J., Dobbs K., Delmonte O. M., Danielson J. J., Biondi A., Bettini L. R., D'Angio M., Beretta I., Imberti L., Sottini A., Quaresima V., Quiros-Roldan E., Rossi C., Castagnoli R., Montagna D., Licari A., Marseglia G. L., Chiu C., and Grzymski J. J.
Abstract: Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B∗15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.
Published: 2024

4. Abstract No. 177 ▪ FEATURED ABSTRACT A Comparison of Post-Procedural Hemoglobin in Catheter-Directed Thrombolysis vs. Large-Bore Aspiration Thrombectomy for Acute Pulmonary Embolism

Author: Ahmed, J., primary, Patel, K., additional, Ryan, W., additional, Leung, D., additional, and Graif, A., additional
Published: 2024
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5. A novel machine learning-based model predicting lymph node metastasis at robotic assisted radical prostatectomy

Author: Fuligni, D., primary, Castellani, D., additional, Lucarelli, L., additional, Teoh, J.Y-C., additional, Leung, D., additional, Bugis, A., additional, Azhar, R.A., additional, Ghouse, S.M., additional, Gautam, G., additional, Gauhar, V., additional, Campobasso, D., additional, Campi, R., additional, Sakamoto, S., additional, Palagonia, E., additional, Bocciard, A.M., additional, Lee, H.Y., additional, Rubilotta, E., additional, Antonelli, A., additional, Pastore, A.L., additional, Vasdev, N., additional, Gómez Rivas, J., additional, Cormio, L., additional, Ferretti, S., additional, and Galosi, A.B., additional
Published: 2024
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6. Methodological Considerations for Lipid and Polar Component Analyses in Human Skin Stratum Corneum

Author: Berdyshev, E., Bronova, I., Leung, D. Y. M., and Goleva, E.
Published: 2021
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7. How learning new words changes lexical networks during developmental language acquisition

Author: Leung, D. H. W., Howell, P., and Donlan, C.
Subjects: 150
Abstract: The thesis uses connectionist ideas as a basis for understanding lexical processing, in particular how usage factors have an effect on lexical production in early development. The usage factors of word frequency, neighbourhood density and age-of-acquisition are considered and manipulated in word and non-word repetition tasks with children aged 2 to 12 years. First-order neighbourhood density refers to adjacent neighbours of a target word and second-order neighbourhood density refers to neighbours of first-order neighbours. First- and second-order neighbourhood changes over age were calculated. Experiments were conducted to see how these and the other usage factors interact. A particular focus was whether a phone string is processed differently depending on whether it is a word a child knows or is effectively a non-word (i.e. a word not acquired until a later age). A Generative Acquisition Hypothesis Processing Shift Model is proposed explaining how a string of phones that is a non-word (not known by a child of this age) is processed differently to when it is acquired and how this leads to different interactions between usage factors on lexical processing. The thesis then extends this model by investigating usage factors in Cantonese-English bilinguals as well as Cantonese monolinguals. The results provide a better understanding about how the lexicon develops over ages and how the links between words changes (using the neighbourhood density statistics) within children of different ages and between two languages in bilingual children.
Published: 2016

8. Factors Affecting Trends in Societal Indicators of Ageing Well in Hong Kong: Policies, Politics and Pandemics

Author: Woo, Jean, Leung, D., Yu, R., Lee, R., and Wong, H.
Published: 2021
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9. Bidirectional associations between IgE‐mediated food allergy and atopic dermatitis.

Author: Venter, C., Pickett‐Nairne, K., Glueck, D. H., Nevalainen, J., Greenhawt, M., Metsala, J., Sauder, K. A., Perng, W., Fleischer, D. M., Leung, D., and Dabelea, D.
Subjects: MEDICAL terminology, MEDICAL personnel, ELECTRONIC health records, FOOD allergy, MEDICAL history taking, PEANUT allergy, MILK allergy
Abstract: This document summarizes a study on the relationship between atopic dermatitis (AD) and IgE-mediated food allergy (FA) in children. The study found that children with AD were more likely to develop FA, and vice versa. However, the study had limitations, such as not assessing the severity of AD and having a small sample size for cases of FA. The findings suggest that AD and FA may be related and further research is needed to understand and address these conditions. [Extracted from the article]
Published: 2024
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10. A64 HUMAN INTESINAL ORGANOIDS AS A MODEL FOR GASTROINTESTINAL FUNCTION AND TOXICITY SCREENING

Author: Stahl, M, primary, Leung, D, additional, Anderson, W, additional, Conlin, V, additional, Eaves, A, additional, Louis, S A, additional, and Conder, R K, additional
Published: 2024
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11. A100 HEREDITARY HEMORRHAGIC TELANGIECTASIA: MORE THAN JUST ANOTHER RECTAL BLEED

Author: Leung, D, primary, Guo, J Y, additional, Zepeda-Gomez, S, additional, Wesilenko, S, additional, Halloran, B, additional, and Vethanayagam, D, additional
Published: 2024
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12. 76P Utilization of g score in early oncology drug development: Impact on study design and early go/no-go decision

Author: He, P., primary, Gambhire, D., additional, Zhou, H., additional, Ma, X., additional, Emura, Y., additional, Laadem, A., additional, Leung, D., additional, Bates, S.E., additional, Fojo, A.T., additional, and Rixe, O., additional
Published: 2024
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13. Optimising the acid–base ratio of Mg–Al layered double oxides to enhance CO2 capture performance: the critical role of calcination conditions

Author: Leung, D. W. Justin, primary, Laney, Katherine R., additional, Kenyon, Philip, additional, Rees, Nicholas H., additional, Buffet, Jean-Charles, additional, Chen, Chunping, additional, and O'Hare, Dermot, additional
Published: 2024
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14. On the trajectory of discrimination: A meta-analysis and forecasting survey capturing 44 years of field experiments on gender and hiring decisions

Author: Schaerer, M, Plessis, C, Nguyen, M, Aert, R, Tiokhin, L, Lakens, D, Clemente, E, Pfeiffer, T, Dreber, A, Johannesson, M, Clark, C, Uhlmann, E, Abraham, A, Adamus, M, Akinci, C, Alberti, F, Alsharawy, A, Alzahawi, S, Anseel, F, Arndt, F, Balkan, B, Baskin, E, Bearden, C, Benotsch, E, Bernritter, S, Black, S, Bleidorn, W, Boysen, A, Brienza, J, Brown, M, Brown, S, Brown, J, Buckley, J, Buttliere, B, Byrd, N, Cigler, H, Capitan, T, Cherubini, P, Chong, S, Ciftci, E, Conrad, C, Conway, P, Costa, E, Cox, J, Cox, D, Cruz, F, Dawson, I, Demiral, E, Derrick, J, Doshi, S, Dunleavy, D, Durham, J, Elbaek, C, Ellis, D, Ert, E, Espinoza, M, Fullbrunn, S, Fath, S, Furrer, R, Fiala, L, Fillon, A, Forsgren, M, Fytraki, A, Galarza, F, Gandhi, L, Garrison, S, Geraldes, D, Ghasemi, O, Gjoneska, B, Gothilander, J, Gruhn, D, Grieder, M, Hafenbradl, S, Halkias, G, Hancock, R, Hantula, D, Harton, H, Hoffmann, C, Holzmeister, F, Horak, F, Hosch, A, Imada, H, Ioannidis, K, Jaeger, B, Janas, M, Janik, B, Kc, R, Keel, P, Keeley, J, Keller, L, Kenrick, D, Kiely, K, Knutsson, M, Kovacheva, A, Kovera, M, Krivoshchekov, V, Krumrei-Mancuso, E, Kulibert, D, Lacko, D, Lemay, E, Leung, D, Li, F, Lin, H, Lorenzo, K, Lorenzo-Luaces, L, Lou, N, Lovakov, A, Luzardo, A, Macaulay, S, Madan, C, Mahmoud, O, Makel, M, Mari, S, Fages, D, Marsh, A, Mccarthy, R, Mercier, B, Milfont, T, Mittlaender, S, Montoya, A, Moyer, A, Myrseth, K, Navarro-Martinez, D, Nelson, A, Neyse, L, Minghui, N, Niszczota, P, Obrecht, N, Otterbring, T, Panlilio, Z, Park, L, Pauer, S, Pavlov, Y, Pentek, I, Pereyra, J, Perkowski, P, Pew, E, Peynircioglu, Z, Pezzo, M, Pirrone, A, Plonsky, O, Porfirio, J, Pownall, M, Prochnicki, M, Protzko, J, Roer, J, Rahnev, D, Reis, H, Rios, K, Rodrigues, D, Rodriguez, P, Roth, Y, Ruffle, B, Samahita, M, Schmidt, A, Schoemann, M, Schoenegger, P, Schwebel, D, Segovia, A, Sherman, J, Siegenthaler, S, Siem, B, Sirota, M, Smith, E, Stamatogiannakis, A, Stewart-Williams, S, Storage, D, Su, Y, Talbert, E, Todd, A, Tonin, M, Trautmann, S, Travaglino, G, Tsang, J, Veldhuizen, R, Varnum, M, Walf, A, Wallrich, L, Wang, K, Ward, D, Waugh, C, Wingen, T, Woike, J, Wollbrant, C, Wu, S, Wylie, K, Xiao, Q, Xue, S, Yakobi, O, Zayas, V, Zheng, J, Zhong, Y, Zogmaister, C, Zolopa, C, Lisa, N, Chin Wen, O, Dmitry, G, Schaerer M., Plessis C. D., Nguyen M. H. B., Aert R. C. M. V., Tiokhin L., Lakens D., Clemente E. G., Pfeiffer T., Dreber A., Johannesson M., Clark C. J., Uhlmann E. L., Abraham A. T., Adamus M., Akinci C., Alberti F., Alsharawy A. M., Alzahawi S., Anseel F., Arndt F., Balkan B., Baskin E., Bearden C. E., Benotsch E. G., Bernritter S., Black S. R., Bleidorn W., Boysen A. P., Brienza J. P., Brown M., Brown S. E. V., Brown J. W., Buckley J., Buttliere B., Byrd N., Cigler H., Capitan T., Cherubini P., Chong S. Y., Ciftci E. E., Conrad C. D., Conway P., Costa E., Cox J. A., Cox D. J., Cruz F., Dawson I. G. J., Demiral E. E., Derrick J. L., Doshi S., Dunleavy D. J., Durham J. D., Elbaek C. T., Ellis D. A., Ert E., Espinoza M. P., Fullbrunn S. C., Fath S., Furrer R., Fiala L., Fillon A. A., Forsgren M., Fytraki A. T., Galarza F. B., Gandhi L., Garrison S. M., Geraldes D., Ghasemi O., Gjoneska B., Gothilander J., Gruhn D., Grieder M., Hafenbradl S., Halkias G., Hancock R., Hantula D. A., Harton H. C., Hoffmann C. P., Holzmeister F., Horak F., Hosch A. -K., Imada H., Ioannidis K., Jaeger B., Janas M., Janik B., Kc R. P., Keel P. K., Keeley J. W., Keller L., Kenrick D. T., Kiely K. M., Knutsson M., Kovacheva A., Kovera M. B., Krivoshchekov V., Krumrei-Mancuso E. J., Kulibert D., Lacko D., Lemay E. P., Leung D. W., Li F., Lin H., Lorenzo K. E., Lorenzo-Luaces L., Lou N. M., Lovakov A., Luzardo A., MacAulay S. C., Madan C. R., Mahmoud O., Makel M. C., Mari S., Fages D. M., Marsh A. A., McCarthy R. J., Mercier B., Milfont T. L., Mittlaender S., Montoya A. K., Moyer A., Myrseth K. O. R., Navarro-Martinez D., Nelson A. J., Neyse L., Minghui N., Niszczota P., Obrecht N. A., Otterbring T., Panlilio Z. A., Park L. E., Pauer S., Pavlov Y. G., Pentek I., Pereyra J. S., Perkowski P., Pew E., Peynircioglu Z. F., Pezzo M. V., Pirrone A., Plonsky O., Porfirio J. C. C., Pownall M., Prochnicki M. M., Protzko J., Roer J. P., Rahnev D., Reis H. T., Rios K., Rodrigues D. L., Rodriguez P., Roth Y., Ruffle B. J., Samahita M., Schmidt A., Schoemann M., Schoenegger P., Schwebel D. C., Segovia A. M., Sherman J. W., Siegenthaler S., Siem B., Sirota M., Smith E. R., Stamatogiannakis A., Stewart-Williams S., Storage D., Su Y., Talbert E. J., Todd A. R., Tonin M., Trautmann S. T., Travaglino G. A., Tsang J. -A., Veldhuizen R. V., Varnum M. E. W., Walf A. A., Wallrich L., Wang K., Ward D. E., Waugh C. E., Wingen T., Woike J. K., Wollbrant C. E., Wu S., Wylie K., Xiao Q., Xue S. Y., Yakobi O., Zayas V., Zheng J., Zhong Y., Zogmaister C., Zolopa C. S., Lisa N., Chin Wen O., Dmitry G., Schaerer, M, Plessis, C, Nguyen, M, Aert, R, Tiokhin, L, Lakens, D, Clemente, E, Pfeiffer, T, Dreber, A, Johannesson, M, Clark, C, Uhlmann, E, Abraham, A, Adamus, M, Akinci, C, Alberti, F, Alsharawy, A, Alzahawi, S, Anseel, F, Arndt, F, Balkan, B, Baskin, E, Bearden, C, Benotsch, E, Bernritter, S, Black, S, Bleidorn, W, Boysen, A, Brienza, J, Brown, M, Brown, S, Brown, J, Buckley, J, Buttliere, B, Byrd, N, Cigler, H, Capitan, T, Cherubini, P, Chong, S, Ciftci, E, Conrad, C, Conway, P, Costa, E, Cox, J, Cox, D, Cruz, F, Dawson, I, Demiral, E, Derrick, J, Doshi, S, Dunleavy, D, Durham, J, Elbaek, C, Ellis, D, Ert, E, Espinoza, M, Fullbrunn, S, Fath, S, Furrer, R, Fiala, L, Fillon, A, Forsgren, M, Fytraki, A, Galarza, F, Gandhi, L, Garrison, S, Geraldes, D, Ghasemi, O, Gjoneska, B, Gothilander, J, Gruhn, D, Grieder, M, Hafenbradl, S, Halkias, G, Hancock, R, Hantula, D, Harton, H, Hoffmann, C, Holzmeister, F, Horak, F, Hosch, A, Imada, H, Ioannidis, K, Jaeger, B, Janas, M, Janik, B, Kc, R, Keel, P, Keeley, J, Keller, L, Kenrick, D, Kiely, K, Knutsson, M, Kovacheva, A, Kovera, M, Krivoshchekov, V, Krumrei-Mancuso, E, Kulibert, D, Lacko, D, Lemay, E, Leung, D, Li, F, Lin, H, Lorenzo, K, Lorenzo-Luaces, L, Lou, N, Lovakov, A, Luzardo, A, Macaulay, S, Madan, C, Mahmoud, O, Makel, M, Mari, S, Fages, D, Marsh, A, Mccarthy, R, Mercier, B, Milfont, T, Mittlaender, S, Montoya, A, Moyer, A, Myrseth, K, Navarro-Martinez, D, Nelson, A, Neyse, L, Minghui, N, Niszczota, P, Obrecht, N, Otterbring, T, Panlilio, Z, Park, L, Pauer, S, Pavlov, Y, Pentek, I, Pereyra, J, Perkowski, P, Pew, E, Peynircioglu, Z, Pezzo, M, Pirrone, A, Plonsky, O, Porfirio, J, Pownall, M, Prochnicki, M, Protzko, J, Roer, J, Rahnev, D, Reis, H, Rios, K, Rodrigues, D, Rodriguez, P, Roth, Y, Ruffle, B, Samahita, M, Schmidt, A, Schoemann, M, Schoenegger, P, Schwebel, D, Segovia, A, Sherman, J, Siegenthaler, S, Siem, B, Sirota, M, Smith, E, Stamatogiannakis, A, Stewart-Williams, S, Storage, D, Su, Y, Talbert, E, Todd, A, Tonin, M, Trautmann, S, Travaglino, G, Tsang, J, Veldhuizen, R, Varnum, M, Walf, A, Wallrich, L, Wang, K, Ward, D, Waugh, C, Wingen, T, Woike, J, Wollbrant, C, Wu, S, Wylie, K, Xiao, Q, Xue, S, Yakobi, O, Zayas, V, Zheng, J, Zhong, Y, Zogmaister, C, Zolopa, C, Lisa, N, Chin Wen, O, Dmitry, G, Schaerer M., Plessis C. D., Nguyen M. H. B., Aert R. C. M. V., Tiokhin L., Lakens D., Clemente E. G., Pfeiffer T., Dreber A., Johannesson M., Clark C. J., Uhlmann E. L., Abraham A. T., Adamus M., Akinci C., Alberti F., Alsharawy A. M., Alzahawi S., Anseel F., Arndt F., Balkan B., Baskin E., Bearden C. E., Benotsch E. G., Bernritter S., Black S. R., Bleidorn W., Boysen A. P., Brienza J. P., Brown M., Brown S. E. V., Brown J. W., Buckley J., Buttliere B., Byrd N., Cigler H., Capitan T., Cherubini P., Chong S. Y., Ciftci E. E., Conrad C. D., Conway P., Costa E., Cox J. A., Cox D. J., Cruz F., Dawson I. G. J., Demiral E. E., Derrick J. L., Doshi S., Dunleavy D. J., Durham J. D., Elbaek C. T., Ellis D. A., Ert E., Espinoza M. P., Fullbrunn S. C., Fath S., Furrer R., Fiala L., Fillon A. A., Forsgren M., Fytraki A. T., Galarza F. B., Gandhi L., Garrison S. M., Geraldes D., Ghasemi O., Gjoneska B., Gothilander J., Gruhn D., Grieder M., Hafenbradl S., Halkias G., Hancock R., Hantula D. A., Harton H. C., Hoffmann C. P., Holzmeister F., Horak F., Hosch A. -K., Imada H., Ioannidis K., Jaeger B., Janas M., Janik B., Kc R. P., Keel P. K., Keeley J. W., Keller L., Kenrick D. T., Kiely K. M., Knutsson M., Kovacheva A., Kovera M. B., Krivoshchekov V., Krumrei-Mancuso E. J., Kulibert D., Lacko D., Lemay E. P., Leung D. W., Li F., Lin H., Lorenzo K. E., Lorenzo-Luaces L., Lou N. M., Lovakov A., Luzardo A., MacAulay S. C., Madan C. R., Mahmoud O., Makel M. C., Mari S., Fages D. M., Marsh A. A., McCarthy R. J., Mercier B., Milfont T. L., Mittlaender S., Montoya A. K., Moyer A., Myrseth K. O. R., Navarro-Martinez D., Nelson A. J., Neyse L., Minghui N., Niszczota P., Obrecht N. A., Otterbring T., Panlilio Z. A., Park L. E., Pauer S., Pavlov Y. G., Pentek I., Pereyra J. S., Perkowski P., Pew E., Peynircioglu Z. F., Pezzo M. V., Pirrone A., Plonsky O., Porfirio J. C. C., Pownall M., Prochnicki M. M., Protzko J., Roer J. P., Rahnev D., Reis H. T., Rios K., Rodrigues D. L., Rodriguez P., Roth Y., Ruffle B. J., Samahita M., Schmidt A., Schoemann M., Schoenegger P., Schwebel D. C., Segovia A. M., Sherman J. W., Siegenthaler S., Siem B., Sirota M., Smith E. R., Stamatogiannakis A., Stewart-Williams S., Storage D., Su Y., Talbert E. J., Todd A. R., Tonin M., Trautmann S. T., Travaglino G. A., Tsang J. -A., Veldhuizen R. V., Varnum M. E. W., Walf A. A., Wallrich L., Wang K., Ward D. E., Waugh C. E., Wingen T., Woike J. K., Wollbrant C. E., Wu S., Wylie K., Xiao Q., Xue S. Y., Yakobi O., Zayas V., Zheng J., Zhong Y., Zogmaister C., Zolopa C. S., Lisa N., Chin Wen O., and Dmitry G.
Abstract: A preregistered meta-analysis, including 244 effect sizes from 85 field audits and 361,645 individual job applications, tested for gender bias in hiring practices in female-stereotypical and gender-balanced as well as male-stereotypical jobs from 1976 to 2020. A “red team” of independent experts was recruited to increase the rigor and robustness of our meta-analytic approach. A forecasting survey further examined whether laypeople (n = 499 nationally representative adults) and scientists (n = 312) could predict the results. Forecasters correctly anticipated reductions in discrimination against female candidates over time. However, both scientists and laypeople overestimated the continuation of bias against female candidates. Instead, selection bias in favor of male over female candidates was eliminated and, if anything, slightly reversed in sign starting in 2009 for mixed-gender and male-stereotypical jobs in our sample. Forecasters further failed to anticipate that discrimination against male candidates for stereotypically female jobs would remain stable across the decades.
Published: 2023

15. Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Author: Matuozzo, D, Talouarn, E, Marchal, A, Zhang, P, Manry, J, Seeleuthner, Y, Zhang, Y, Bolze, A, Chaldebas, M, Milisavljevic, B, Gervais, A, Bastard, P, Asano, T, Bizien, L, Barzaghi, F, Abolhassani, H, Abou Tayoun, A, Aiuti, A, Alavi Darazam, I, Allende, L, Alonso-Arias, R, Arias, A, Aytekin, G, Bergman, P, Bondesan, S, Bryceson, Y, Bustos, I, Cabrera-Marante, O, Carcel, S, Carrera, P, Casari, G, Chaibi, K, Colobran, R, Condino-Neto, A, Covill, L, Delmonte, O, El Zein, L, Flores, C, Gregersen, P, Gut, M, Haerynck, F, Halwani, R, Hancerli, S, Hammarstrom, L, Hatipoglu, N, Karbuz, A, Keles, S, Kyheng, C, Leon-Lopez, R, Franco, J, Mansouri, D, Martinez-Picado, J, Metin Akcan, O, Migeotte, I, Morange, P, Morelle, G, Martin-Nalda, A, Novelli, G, Novelli, A, Palabiyik, F, Pan-Hammarstrom, Q, de Diego, R, Planas-Serra, L, Pleguezuelo, D, Prando, C, Pujol, A, Reyes, L, Riviere, J, Rodriguez-Gallego, C, Rojas, J, Rovere-Querini, P, Schluter, A, Shahrooei, M, Sobh, A, Soler-Palacin, P, Tandjaoui-Lambiotte, Y, Tipu, I, Tresoldi, C, Troya, J, van de Beek, D, Zatz, M, Zawadzki, P, Al-Muhsen, S, Alosaimi, M, Alsohime, F, Baris-Feldman, H, Butte, M, Constantinescu, S, Cooper, M, Dalgard, C, Fellay, J, Heath, J, Lau, Y, Lifton, R, Maniatis, T, Mogensen, T, von Bernuth, H, Lermine, A, Vidaud, M, Boland, A, Deleuze, J, Nussbaum, R, Kahn-Kirby, A, Mentre, F, Tubiana, S, Gorochov, G, Tubach, F, Hausfater, P, Al-Mulla, F, Anderson, M, Andreakos, E, Feldman, H, Belot, A, Biggs, C, Bogunovic, D, Bondarenko, A, Bousfiha, A, Brodin, P, Bustamante, C, Chakravorty, S, Christodoulou, J, Desai, M, Drolet, B, Baghdadi, J, Espinosa-Padilla, S, Froidure, A, Hagin, D, Henrickson, S, Hsieh, E, Husebye, E, Imai, K, Itan, Y, Jarvis, E, Karamitros, T, Kisand, K, Ku, C, Ling, Y, Lucas, C, Marodi, L, Milner, J, Mironska, K, Morio, T, Ng, L, O'Farrelly, C, Okada, S, Planas, A, Quintana-Murci, L, Renia, L, Resnick, I, Sancho-Shimizu, V, Sediva, A, Seppanen, M, Shcherbina, A, Slaby, O, Snow, A, 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B., Magazimama-Ext A., Maingret D., Mameri L., Manivet P., Mansouri C., Marcault E., Marey J., Marin N., Marois C., Martin O., Martineau L., Martinez-Lopez C., Martyniuck P., De Farcy P. M., Marzouk N., Masmoudi R., Mebazaa A., Mechai F., Mecozzi F., Mediouni C., Megarbane B., Meghadecha M., Mejean E., Mekinian A., Abdelhadi N. M., Mekni R., Meliti T. S., Lima B. M., Meng P., Merbah S., Messani F., Messaoudi Y., Mewasing B. -I., Meziane L., Michelot-Burger C., Mignot F., Minka F. H., Miyara M., Moine P., Molina J. -M., Montegnies-Boulet A., Monti A., Montlahuc C., Montout A. -L., Moores A., Morbieu C., Mortelette H., Mouly S., Muzaffar R., Nacerddine C. I., Nadal M., Nadif H., Nassarmadji K., Natella P., Ndingamondze S., Neraal S., Nguyen C., N'Guyen B., Larmurier I. N., Nlomenyengue L., Noel N., Nunes H., Omar E., Ouazene Z., Ouedraogo E., Ouelaa W., Oukhedouma A., Amara Y. O., Oya H., Oziel J., Padilla T., Paillaud E., Paiva S., Parfait B., Parize P., Parizot C., Parrot A., Pavot A., Peaudecerf L., Pene F., Pepin M., Pernet J., Pernin C., Petit M., Peyrony O., Pietri M. -P., Pietri O., De Chambrun M. P., Pinson M., Pintado C., Pires C., Planquette B., Poirier S., Pomel A. -L., Pons S., Ponscarme D., Pourcelot A., Pourcher V., Pouvaret A., Prever F., Previlon M., Prevost M., Provoost M. -J., Quemeneur C., Rafat C., Rami A., Ranque B., Raphael M., Raphalen J. H., Rastoin A., Raux M., Rebai A., Reby M., Regent A., Regrag A., Resche-Rigon M., Ressaire Q., Richard C., Richard M., Robert M., Rohaut B., Rolland-Debord C., Ropers J., Roque-Afonso A. -M., Rosso C., Rousseaux M., Rousseaux N., Roux S., Roux L., Rouzaud C., Rozes A., Rubenstein E., Sabate J. -M., Sabet S., Sacleux S. -C., Kermanach N. S., Saliba F., Salmon D., Savale L., Savary G., Sberro R., Scemla A., Schlemmer F., Schwartz M., Sedfi S., Sefir-Kribel S., Seksik P., Sellier P., Selves A., Sembach N., Semerano L., Senat M. -V., Sene D., Serris A., Sese L., Sghiouar N., Sigaux J., Siguier M., Silvain J., Simon N., Simon T., Skandri L. I., Slimani M., Snauwaert A., Sokol H., Soliman H., Soltani N., Soyer B., Steg G., Suarez L., Szwebel T. -A., Taffame K., Tantet C., Tateo M., Theodose I., Thiebaud P., Thomas C., Tiercelet K., Tisserand J., Tomczak C., Torelino K., Touam-Ext F., Toumi L., Toury G., Toy-Miou M., Lien O. T. D. T., Trandinh A., Treluyer J. -M., Trinque B., Truchot J., Tunesi S., Turpin M., Turpin A., Urbina T., Narvaez R. U., Uzunhan Y., Vaittinadaayar P., Valent A., Valentian M., Valin N., Vallet H., Vaz M., Vazquezibarra M. -A., Vedie B., Velly L., Verstuyft C., Viallette C., Vicaut E., Vignes D., Vimpere D., Virlouvet M., Voiriot G., Voisot L., Weiss E., Weiss N., Winchenne A., Yordanov Y., Zafrani L., Zaidan M., Zaidi W., Zak C., Zarhrate-Ghoul A., Zatout O., Zeino S., Zeitouni M., Zemirli N., Zerah L., Zia O., Ziol M., Zolario O., Zuber J., Andrejak C., Angoulvant F., Bachelet D., Bartoli M., Basmaci R., Behilill S., Beluze M., Benkerrou D., Bhavsar K., Bouadma L., Bouchez S., Bouscambert M., Cervantes-Gonzalez M., Chair A., Coelho A., d'Ortenzio E., Debray M. -P., Deconinck L., Deplanque D., Descamps D., Desvallee M., Diallo A., Diouf A., Dorival C., Dubos F., Duval X., Elharrar B., Eloy P., Enouf V., Esperou H., Esposito-Farese M., Devouge E. F., Gault N., Gaymard A., Ghosn J., Gigante T., Gilg M., Guedj J., Hoctin A., Hoffmann I., Houas I., Hulot J. -S., Jaafoura S., Kaguelidou F., Kali S., Khalil A., Khan C., Laouenan C., Laribi S., Le M., Le Hingrat Q., Le Mestre S., Le Nagard H., Lescure F. -X., Levy Y., Lingas G., Lucet J. C., Malvy D., Mambert M., Meziane A., Mouquet H., Mullaert J., Neant N., Nguyen D., Noret M., Nseir S., Papadopoulos A., Paul C., Peiffer-Smadja N., Perpoint T., Petrov-Sanchez V., Peytavin G., Pham H., Picone O., Puechal O., Rabaud C., Rosa-Calatrava M., Rossignol B., Rossignol P., Roy C., Schneider M., Su R., Tardivon C., Tellier M. -C., Teoule F., Terrier O., Timsit J. -F., Tual C., Van Der Werf S., Vanel N., Veislinger A., Visseaux B., Wiedemann A., Yazdanpanah Y., Alavoine L., Behillil S., Burdet C., Charpentier C., Dechanet A., Ecobichon J. -L., Frezouls W., Houhou N., Lehacaut J., Letrou S., Lina B., Manchon P., Nouroudine M., Piquard V., Quintin C., Thy M., Vignali V., Chahine A., Waucquier N., Migaud M. -C., Djossou F., Mergeay-Fabre M., Lucarelli A., Demar M., Bruneau L., Gerardin P., Maillot A., Payet C., Laviolle B., Laine F., Paris C., Desille-Dugast M., Fouchard J., Pistone T., Perreau P., Gissot V., Goas C. L. E., Montagne S., Richard L., Chirouze C., Bouiller K., Desmarets M., Meunier A., Bourgeon M., Lefevre B., Jeulin H., Legrand K., Lomazzi S., Tardy B., Gagneux-Brunon A., Bertholon F., Botelho-Nevers E., Christelle K., Nicolas L., Roufai L., Amat K., Couffin-Cadiergues S., Hendou S., Foti G., Bellani G., Citerio G., Contro E., Pesci A., Valsecchi M. G., Cazzaniga M., Abad J., Accordino G., Achille C., Aguilera-Albesa S., Aguilo-Cucurull A., Ozkan E. A., Albisures J. A. R., Aldave J. C., Ramos M. A., Khan T. A., Aliberti A., Nadji S. A., Alkan G., AlKhater S. A., Allardet-Servent J., Alshahrani M. S., Alsina L., Amoura Z., Antoli A., Arrestier R., Aubart M., Auguet T., Avramenko I., Azot A., Bahram S., Bajolle F., Baldanti F., Baldolli A., Ballester M., Barrou B., Basso S., Bayhan G. I., Bezrodnik L., Bilbao A., Blanchard-Rohner G., Blanco I., Blandinieres A., Blazquez-Gamero D., Bloomfield M., Bolivar-Prados M., Borghesi A., Borie R., Botdhlo-Nevers E., Bousquet A., Boutolleau D., Bouvattier C., Boyarchuk O., Bravais J., Briones M. L., Brunner M. -E., Bruno R., Bueno M. R. P., Bukhari H., Bustamante J., Agra J. J. C., Capra R., Carapito R., Carrabba M., Casasnovas C., Caseris M., Cassaniti I., Castelle M., Castelli F., de Vera M. C., Castro M. V., Catherinot E., Celik J. B., Ceschi A., Chalumeau M., Charbit B., Cheng M. P., Clave P., Clotet B., Codina A., Comoli P., Corsico A. G., Sozeri B., Coskuner T., Cvetkovski A., Cyrus C., Dalmau D., Danion F., Darley D. R., Das V., Dauby N., Dauger S., De Munter P., de Pontual L., Dehban A., Delplancq G., Desguerre I., Di Sabatino A., Diehl J. -L., Dobbelaere S., Dominguez-Garrido E., Dubost C., Ekwall O., Bozdemir S. E., Elnagdy M. H., Emiroglu M., Endo A., Erdeniz E. H., Aytekin S. E., Lasa M. P. E., Euvrard R., Fabio G., Faivre L., Falck A., Faure M., Arquero M. F., Ferrer R., Ferreres J., Francois B., Fumado V., Fung K. S. C., Fusco F., Gagro A., Solis B. G., Garcon P., Gaussem P., Gayretli Z., Gil-Herrera J., Gilardin L., Gatineau A. G., Girona-Alarcon M., Godinez K. A. C., Goffard J. -C., Gonzales N., Gonzalez-Granado L. I., Gonzalez-Montelongo R., Guerder A., Gulhan B., Gumucio V. D., Hanitsch L. G., Gunst J., Hadjadj J., Hariyan T., Heppekcan D., Hernandez-Brito E., Ho P. -K., Holanda-Pena M. S., Horcajada J. P., Hraiech S., Humbert L., Hung I. F. N., Iglesias A. D., Inigo-Campos A., Jamme M., Arranz M. J., Jimeno M. -T., Jordan I., Yuksek S. K., Kara Y. B., Karahan A., Yasar K. K., Kasapcopur O., Kashimada K., Demirkol Y. K., Kido Y., Kizil C., Kilic A. O., Klocperk A., Koutsoukou A., Krol Z. J., Ksouri H., Kuentz P., Kwan A. M. C., Kwan Y. W. M., Kwok J. S. Y., Lagier J. -C., Lam D. S. Y., Lampropoulou V., Le Bourgeois F., Leo Y. -S., Leung D., Levin M., Levy M., Levy R., Li Z., Lilleri D., Lima E. J. A. B., Linglart A., Lopez-Collazo E., Lorenzo-Salazar J. M., Louapre C., Lubetzki C., Lung K. -C., Luyt C. -E., Lye D. C., Magnone C., Marchioni E., Marioli C., Marjani M., Marques L., Pereira J. M., Pueyo D. M., Marzana I., Mata-Martinez C., Mathian A., Matos L. R. B., Matthews G. V., Mayaux J., McLaughlin-Garcia R., Meersseman P., Mege J. -L., Mekontso-Dessap A., Melki I., Meloni F., Meritet J. -F., Merlani P., Akcan O. M., Mezidi M., Millereux M., Million M., Mirault T., Mircher C., Mirsaeidi M., Mizoguchi Y., Modi B. P., Mojoli F., Moncomble E., Melian A. M., Martinez A. M., Morandeira F., Mordacq C., Mouly S. J., Munoz-Barrera A., Nafati C., Nagashima S., Nakagama Y., Neven B., Neves J. F., Ng Y. -Y., Nielly H., Medina Y. N., Cuadros E. N., Ocejo-Vinyals J. G., Okamoto K., Oualha M., Ouedrani A., Ozcelik T., Ozkaya-Parlakay A., Pagani M., Papadaki M., Parola P., Pascreau T., Paul S., Paz-Artal E., Pedraza S., Pellecer N. C. G., Pellegrini S., Perez-Fernandez X. L., Philippe A., Philippot Q., Picod A., Piralla A., Ploin D., Poissy J., Poncelet G., Poulakou G., Pouletty M. S., Pourshahnazari P., Qiu-Chen J. L., Quentric P., Rambaud T., Raoult D., Raoult V., Rebillat A. -S., Redin C., Resmini L., Ricart P., Richard J. -C., Rigo-Bonnin R., rivet N., Rocamora-Blanch G., Rodero M. P., Rodrigo C., Rodriguez L. A., Rodriguez-Palmero A., Romero C. S., Rothenbuhler A., Roux D., Rovina N., Rozenberg F., Ruch Y., Ruiz M., del Prado M. Y. R., Ruiz-Rodriguez J. C., Sabater-Riera J., Saks K., Salagianni M., Sanchez O., Sanchez-Montalva A., Sanchez-Ramon S., Schidlowski L., Schmidt J., Schmidt M., Schuetz C., Schweitzer C. E., Scolari F., Seijo L., Seminario A. G., Seng P., Senoglu S., Seppanen M., Llovich A. S., Siguret V., Siouti E., Smadja D. M., Smith N., Solanich X., Sole-Violan J., Soler C., Stella G. M., Stepanovskiy Y., Stoclin A., Taccone F., Taupin J. -L., Tavernier S. J., Tello L. V., Terrier B., Thiery G., Thorball C., Thorn K., Thumerelle C., Tolstrup M., Tomasoni G., Toubiana J., Alvarez J. T., Triantafyllia V., Trouillet-Assant S., Tsang O. T. Y., Tserel L., Tso E. Y. K., Tucci A., Oz S. K. T., Ursini M. V., Utsumi T., Vabres P., Valencia-Ramos J., Van Den Rym A. M., Vandernoot I., Velez-Santamaria V., Veliz S. P. Z., Vidigal M. C., Viel S., Villain C., Vilaire-Meunier M. E., Villar-Garcia J., Vincent A., Volokha A., Vuotto F., Wauters E., Wauters J., Wu A. K. L., Wu T. -C., Yahsi A., Yesilbas O., Yildiz M., Young B. E., Yukselmis U., Zecca M., Zuccaro V., Van Praet J., Lambrecht B. N., Van Braeckel E., Bosteels C., Hoste L., Hoste E., Bauters F., De Clercq J., Heijmans C., Slabbynck H., Naesens L., Florkin B., Boulanger C., Vanderlinden D., Berkell M., Carelli V., Malhotra S., Mattiaccio A., Pippucci T., Seri M., Tacconelli E., van Agtmael M., Algera A. G., Appelman B., van Baarle F., Bax D., Beudel M., Bogaard H. J., Bomers M., Bonta P., Bos L., Botta M., de Brabander J., de Bree G., de Bruin S., Buis D. T. P., Bugiani M., Bulle E., Cloherty O. C. A., Dijkstra M., Dongelmans D. A., Dujardin R. W. G., Elbers P., Fleuren L., Geijtenbeek S. G. T., Girbes A., Goorhuis B., Grobusch M. P., Hafkamp F., Hagens L., Hamann J., Harris V., Hemke R., Heunks S. M. H. L., Hollmann M., Horn J., Hovius J. W., de Jong M. D., Koning R., Lim E. H. T., van Mourik N., Nellen J., Nossent E. J., Paulus F., Peters E., Pina-Fuentes D. A. I., van der Poll T., Preckel B., Prins J. M., Raasveld J., Reijnders T., de Rotte M. C. F. J., Schinkel M., Schultz M. J., Schrauwen F. A. P., Schuurmans A., Schuurmans J., Sigaloff K., Slim M. A., Smeele P., Smit M., Stijnis C. S., Stilma W., Teunissen C., Thoral P., Tsonas A. M., Tuinman P. R., van der Valk M., Veelo D., Volleman C., de Vries H., Vught L. A., van Vugt M., Wouters D., Zwinderman A. H., Brouwer M. C., Wiersinga W. J., Vlaar A. P. J., Tompkins M. F., Alba C., Hupalo D. N., Rosenberger J., Sukumar G., Wilkerson M. D., Zhang X., Lack J., Oler A. J., Dobbs K., Danielson J. J., Biondi A., Bettini L. R., D'Angio' M., Beretta I., Imberti L., Sottini A., Quaresima V., Quiros-Roldan E., Rossi C., Meyts I., Zhang S. -Y., Puel A., Notarangelo L. D., Boisson-Dupuis S., Su H. C., Boisson B., Jouanguy E., Zhang Q., Abel L., Cobat A., Matuozzo, D, Talouarn, E, Marchal, A, Zhang, P, Manry, J, Seeleuthner, Y, Zhang, Y, Bolze, A, Chaldebas, M, Milisavljevic, B, Gervais, A, Bastard, P, Asano, T, Bizien, L, Barzaghi, F, Abolhassani, H, Abou Tayoun, A, Aiuti, A, Alavi Darazam, I, Allende, L, Alonso-Arias, R, Arias, A, Aytekin, G, Bergman, P, Bondesan, S, Bryceson, Y, Bustos, I, Cabrera-Marante, O, Carcel, S, Carrera, P, Casari, G, Chaibi, K, Colobran, R, Condino-Neto, A, Covill, L, Delmonte, O, El Zein, L, Flores, C, Gregersen, P, Gut, M, Haerynck, F, Halwani, R, Hancerli, S, Hammarstrom, L, Hatipoglu, N, Karbuz, A, Keles, S, Kyheng, C, Leon-Lopez, R, Franco, J, Mansouri, D, Martinez-Picado, J, Metin Akcan, O, Migeotte, I, Morange, P, Morelle, G, Martin-Nalda, A, Novelli, G, Novelli, A, Palabiyik, F, Pan-Hammarstrom, Q, de Diego, R, Planas-Serra, L, Pleguezuelo, D, Prando, C, Pujol, A, Reyes, L, Riviere, J, Rodriguez-Gallego, C, Rojas, J, Rovere-Querini, P, 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E., De Castro N., De Rycke Y., Del Pozo L., Delannoy Q., Delay M., Deleris R., Delforge J., Delphine L., Demare N., Demeret S., Demoule A., Deniau A., Depret F., Derolez S., Derradji O., Derridj N., Descamps V., Deschamps L., Desconclois C., Desnos C., Desongins K., Dhote R., Diallo B., Didier M., Diemer M., Diez S., Djadi-Prat J., Monnory F. -Z. D., Djebara S., Djebra N., Djietcheu M., Djillali H., Djouadi N., Donneger S., Dos Santos C., Dournon N., Dres M., Droctove L., Drogrey M., Dropy M., Drouet E., Dubosq V., Dubreucq E., Dubus E., Duchemann B., Duchenoy T., Dudoignon E., Dufau R., Dumas F., Duran C., Duron E., Durrbach A., Duvivier C., Ebstein N., Khalifa J. E., Elabbadi A., Elie C., Ernotte G., Esling A., Etienne M., Eyer X., Fartoukh M., Fayali T., Fermaut M., Fiorentino A., Fliss S., Fournier M. -C., Fournier B., Francois H., Freynet O., Frigout Y., Fromont I., Fuentes A., Furet T., Galand J., Garnier M., Gaubert A., Gaudry S., Gaugain S., Gauthier D., Gautier M., Georgin-Lavialle S., Geromin D., Ghalayini M., Ghaleh B., Ghezal M., Gibelin A., Gimeno L., Girard B., Leprieur B. G., Gomes D., Gomes-Pires E., Gouge A., Gouja A., Goulet H., Goupil S., De Bouille J. G., Gras J., Greffe S., Grimaldi L., Guedeney P., Guidet B., Guillo M., Gulczynski M., Hadjam T., Haguenauer D., Hammal S., Hammoudi N., Hanon O., Harrois A., Hautem C., Hekimian G., Heming N., Hermine O., Ho S., Houllier M., Huot B., Huscenot T., Saied W. I., Ikherbane G., Imarazene M., Ingiliz P., Iratni L., Jaureguiberry S., Jean-Marc J. -F., Jeyarajasingham D., Jouany P., Jouis V., Jourdaine C., Kafif O., Kallala R., Katsahian S., Kelesyan L., Keo V., Ketz F., Khamis W., Khelili E., Khellaf M., Youkou C. G. K., Kounis I., Kpalma G., Krause J., Labbe V., Lacombe K., Lacorte J. -M., Lafont A. G., Lafont E., Lagha L., Lamhaut L., Lancelot A., Landman C., Lanternier F., Larcheveque C., Combe C. L., Lassel L., Laverdant B., Lavergne C., Lavillegrand J. -R., Lazureanu P., Le Guennec L., Leberre L., Leblanc C., Leboyer M., Lecomte F., Lecorre M., Leenhardt R., Lefebvre M., Lefebvre B., Legendre P., Leger A., Legros L., Legrosse J., Lehuunghia S., Lemarec J., Leporrier-Ext J., Lesein M., Lesur H., Levy V., Levy A., Lopes E., Lopes A., Lopez V., Lopinto J., Lortholary O., Louadah B., Loze B., Lucas M. -L., Lucasamichi A., Luong L. B., Magazimama-Ext A., Maingret D., Mameri L., Manivet P., Mansouri C., Marcault E., Marey J., Marin N., Marois C., Martin O., Martineau L., Martinez-Lopez C., Martyniuck P., De Farcy P. M., Marzouk N., Masmoudi R., Mebazaa A., Mechai F., Mecozzi F., Mediouni C., Megarbane B., Meghadecha M., Mejean E., Mekinian A., Abdelhadi N. M., Mekni R., Meliti T. S., Lima B. M., Meng P., Merbah S., Messani F., Messaoudi Y., Mewasing B. -I., Meziane L., Michelot-Burger C., Mignot F., Minka F. H., Miyara M., Moine P., Molina J. -M., Montegnies-Boulet A., Monti A., Montlahuc C., Montout A. -L., Moores A., Morbieu C., Mortelette H., Mouly S., Muzaffar R., Nacerddine C. I., Nadal M., Nadif H., Nassarmadji K., Natella P., Ndingamondze S., Neraal S., Nguyen C., N'Guyen B., Larmurier I. N., Nlomenyengue L., Noel N., Nunes H., Omar E., Ouazene Z., Ouedraogo E., Ouelaa W., Oukhedouma A., Amara Y. O., Oya H., Oziel J., Padilla T., Paillaud E., Paiva S., Parfait B., Parize P., Parizot C., Parrot A., Pavot A., Peaudecerf L., Pene F., Pepin M., Pernet J., Pernin C., Petit M., Peyrony O., Pietri M. -P., Pietri O., De Chambrun M. P., Pinson M., Pintado C., Pires C., Planquette B., Poirier S., Pomel A. -L., Pons S., Ponscarme D., Pourcelot A., Pourcher V., Pouvaret A., Prever F., Previlon M., Prevost M., Provoost M. -J., Quemeneur C., Rafat C., Rami A., Ranque B., Raphael M., Raphalen J. H., Rastoin A., Raux M., Rebai A., Reby M., Regent A., Regrag A., Resche-Rigon M., Ressaire Q., Richard C., Richard M., Robert M., Rohaut B., Rolland-Debord C., Ropers J., Roque-Afonso A. -M., Rosso C., Rousseaux M., Rousseaux N., Roux S., Roux L., Rouzaud C., Rozes A., Rubenstein E., Sabate J. -M., Sabet S., Sacleux S. -C., Kermanach N. S., Saliba F., Salmon D., Savale L., Savary G., Sberro R., Scemla A., Schlemmer F., Schwartz M., Sedfi S., Sefir-Kribel S., Seksik P., Sellier P., Selves A., Sembach N., Semerano L., Senat M. -V., Sene D., Serris A., Sese L., Sghiouar N., Sigaux J., Siguier M., Silvain J., Simon N., Simon T., Skandri L. I., Slimani M., Snauwaert A., Sokol H., Soliman H., Soltani N., Soyer B., Steg G., Suarez L., Szwebel T. -A., Taffame K., Tantet C., Tateo M., Theodose I., Thiebaud P., Thomas C., Tiercelet K., Tisserand J., Tomczak C., Torelino K., Touam-Ext F., Toumi L., Toury G., Toy-Miou M., Lien O. T. D. T., Trandinh A., Treluyer J. -M., Trinque B., Truchot J., Tunesi S., Turpin M., Turpin A., Urbina T., Narvaez R. U., Uzunhan Y., Vaittinadaayar P., Valent A., Valentian M., Valin N., Vallet H., Vaz M., Vazquezibarra M. -A., Vedie B., Velly L., Verstuyft C., Viallette C., Vicaut E., Vignes D., Vimpere D., Virlouvet M., Voiriot G., Voisot L., Weiss E., Weiss N., Winchenne A., Yordanov Y., Zafrani L., Zaidan M., Zaidi W., Zak C., Zarhrate-Ghoul A., Zatout O., Zeino S., Zeitouni M., Zemirli N., Zerah L., Zia O., Ziol M., Zolario O., Zuber J., Andrejak C., Angoulvant F., Bachelet D., Bartoli M., Basmaci R., Behilill S., Beluze M., Benkerrou D., Bhavsar K., Bouadma L., Bouchez S., Bouscambert M., Cervantes-Gonzalez M., Chair A., Coelho A., d'Ortenzio E., Debray M. -P., Deconinck L., Deplanque D., Descamps D., Desvallee M., Diallo A., Diouf A., Dorival C., Dubos F., Duval X., Elharrar B., Eloy P., Enouf V., Esperou H., Esposito-Farese M., Devouge E. F., Gault N., Gaymard A., Ghosn J., Gigante T., Gilg M., Guedj J., Hoctin A., Hoffmann I., Houas I., Hulot J. -S., Jaafoura S., Kaguelidou F., Kali S., Khalil A., Khan C., Laouenan C., Laribi S., Le M., Le Hingrat Q., Le Mestre S., Le Nagard H., Lescure F. -X., Levy Y., Lingas G., Lucet J. C., Malvy D., Mambert M., Meziane A., Mouquet H., Mullaert J., Neant N., Nguyen D., Noret M., Nseir S., Papadopoulos A., Paul C., Peiffer-Smadja N., Perpoint T., Petrov-Sanchez V., Peytavin G., Pham H., Picone O., Puechal O., Rabaud C., Rosa-Calatrava M., Rossignol B., Rossignol P., Roy C., Schneider M., Su R., Tardivon C., Tellier M. -C., Teoule F., Terrier O., Timsit J. -F., Tual C., Van Der Werf S., Vanel N., Veislinger A., Visseaux B., Wiedemann A., Yazdanpanah Y., Alavoine L., Behillil S., Burdet C., Charpentier C., Dechanet A., Ecobichon J. -L., Frezouls W., Houhou N., Lehacaut J., Letrou S., Lina B., Manchon P., Nouroudine M., Piquard V., Quintin C., Thy M., Vignali V., Chahine A., Waucquier N., Migaud M. -C., Djossou F., Mergeay-Fabre M., Lucarelli A., Demar M., Bruneau L., Gerardin P., Maillot A., Payet C., Laviolle B., Laine F., Paris C., Desille-Dugast M., Fouchard J., Pistone T., Perreau P., Gissot V., Goas C. L. E., Montagne S., Richard L., Chirouze C., Bouiller K., Desmarets M., Meunier A., Bourgeon M., Lefevre B., Jeulin H., Legrand K., Lomazzi S., Tardy B., Gagneux-Brunon A., Bertholon F., Botelho-Nevers E., Christelle K., Nicolas L., Roufai L., Amat K., Couffin-Cadiergues S., Hendou S., Foti G., Bellani G., Citerio G., Contro E., Pesci A., Valsecchi M. G., Cazzaniga M., Abad J., Accordino G., Achille C., Aguilera-Albesa S., Aguilo-Cucurull A., Ozkan E. A., Albisures J. A. R., Aldave J. C., Ramos M. A., Khan T. A., Aliberti A., Nadji S. A., Alkan G., AlKhater S. A., Allardet-Servent J., Alshahrani M. S., Alsina L., Amoura Z., Antoli A., Arrestier R., Aubart M., Auguet T., Avramenko I., Azot A., Bahram S., Bajolle F., Baldanti F., Baldolli A., Ballester M., Barrou B., Basso S., Bayhan G. I., Bezrodnik L., Bilbao A., Blanchard-Rohner G., Blanco I., Blandinieres A., Blazquez-Gamero D., Bloomfield M., Bolivar-Prados M., Borghesi A., Borie R., Botdhlo-Nevers E., Bousquet A., Boutolleau D., Bouvattier C., Boyarchuk O., Bravais J., Briones M. L., Brunner M. -E., Bruno R., Bueno M. R. P., Bukhari H., Bustamante J., Agra J. J. C., Capra R., Carapito R., Carrabba M., Casasnovas C., Caseris M., Cassaniti I., Castelle M., Castelli F., de Vera M. C., Castro M. V., Catherinot E., Celik J. B., Ceschi A., Chalumeau M., Charbit B., Cheng M. P., Clave P., Clotet B., Codina A., Comoli P., Corsico A. G., Sozeri B., Coskuner T., Cvetkovski A., Cyrus C., Dalmau D., Danion F., Darley D. R., Das V., Dauby N., Dauger S., De Munter P., de Pontual L., Dehban A., Delplancq G., Desguerre I., Di Sabatino A., Diehl J. -L., Dobbelaere S., Dominguez-Garrido E., Dubost C., Ekwall O., Bozdemir S. E., Elnagdy M. H., Emiroglu M., Endo A., Erdeniz E. H., Aytekin S. E., Lasa M. P. E., Euvrard R., Fabio G., Faivre L., Falck A., Faure M., Arquero M. F., Ferrer R., Ferreres J., Francois B., Fumado V., Fung K. S. C., Fusco F., Gagro A., Solis B. G., Garcon P., Gaussem P., Gayretli Z., Gil-Herrera J., Gilardin L., Gatineau A. G., Girona-Alarcon M., Godinez K. A. C., Goffard J. -C., Gonzales N., Gonzalez-Granado L. I., Gonzalez-Montelongo R., Guerder A., Gulhan B., Gumucio V. D., Hanitsch L. G., Gunst J., Hadjadj J., Hariyan T., Heppekcan D., Hernandez-Brito E., Ho P. -K., Holanda-Pena M. S., Horcajada J. P., Hraiech S., Humbert L., Hung I. F. N., Iglesias A. D., Inigo-Campos A., Jamme M., Arranz M. J., Jimeno M. -T., Jordan I., Yuksek S. K., Kara Y. B., Karahan A., Yasar K. K., Kasapcopur O., Kashimada K., Demirkol Y. K., Kido Y., Kizil C., Kilic A. O., Klocperk A., Koutsoukou A., Krol Z. J., Ksouri H., Kuentz P., Kwan A. M. C., Kwan Y. W. M., Kwok J. S. Y., Lagier J. -C., Lam D. S. Y., Lampropoulou V., Le Bourgeois F., Leo Y. -S., Leung D., Levin M., Levy M., Levy R., Li Z., Lilleri D., Lima E. J. A. B., Linglart A., Lopez-Collazo E., Lorenzo-Salazar J. M., Louapre C., Lubetzki C., Lung K. -C., Luyt C. -E., Lye D. C., Magnone C., Marchioni E., Marioli C., Marjani M., Marques L., Pereira J. M., Pueyo D. M., Marzana I., Mata-Martinez C., Mathian A., Matos L. R. B., Matthews G. V., Mayaux J., McLaughlin-Garcia R., Meersseman P., Mege J. -L., Mekontso-Dessap A., Melki I., Meloni F., Meritet J. -F., Merlani P., Akcan O. M., Mezidi M., Millereux M., Million M., Mirault T., Mircher C., Mirsaeidi M., Mizoguchi Y., Modi B. P., Mojoli F., Moncomble E., Melian A. M., Martinez A. M., Morandeira F., Mordacq C., Mouly S. J., Munoz-Barrera A., Nafati C., Nagashima S., Nakagama Y., Neven B., Neves J. F., Ng Y. -Y., Nielly H., Medina Y. N., Cuadros E. N., Ocejo-Vinyals J. G., Okamoto K., Oualha M., Ouedrani A., Ozcelik T., Ozkaya-Parlakay A., Pagani M., Papadaki M., Parola P., Pascreau T., Paul S., Paz-Artal E., Pedraza S., Pellecer N. C. G., Pellegrini S., Perez-Fernandez X. L., Philippe A., Philippot Q., Picod A., Piralla A., Ploin D., Poissy J., Poncelet G., Poulakou G., Pouletty M. S., Pourshahnazari P., Qiu-Chen J. L., Quentric P., Rambaud T., Raoult D., Raoult V., Rebillat A. -S., Redin C., Resmini L., Ricart P., Richard J. -C., Rigo-Bonnin R., rivet N., Rocamora-Blanch G., Rodero M. P., Rodrigo C., Rodriguez L. A., Rodriguez-Palmero A., Romero C. S., Rothenbuhler A., Roux D., Rovina N., Rozenberg F., Ruch Y., Ruiz M., del Prado M. Y. R., Ruiz-Rodriguez J. C., Sabater-Riera J., Saks K., Salagianni M., Sanchez O., Sanchez-Montalva A., Sanchez-Ramon S., Schidlowski L., Schmidt J., Schmidt M., Schuetz C., Schweitzer C. E., Scolari F., Seijo L., Seminario A. G., Seng P., Senoglu S., Seppanen M., Llovich A. S., Siguret V., Siouti E., Smadja D. M., Smith N., Solanich X., Sole-Violan J., Soler C., Stella G. M., Stepanovskiy Y., Stoclin A., Taccone F., Taupin J. -L., Tavernier S. J., Tello L. V., Terrier B., Thiery G., Thorball C., Thorn K., Thumerelle C., Tolstrup M., Tomasoni G., Toubiana J., Alvarez J. T., Triantafyllia V., Trouillet-Assant S., Tsang O. T. Y., Tserel L., Tso E. Y. K., Tucci A., Oz S. K. T., Ursini M. V., Utsumi T., Vabres P., Valencia-Ramos J., Van Den Rym A. M., Vandernoot I., Velez-Santamaria V., Veliz S. P. Z., Vidigal M. C., Viel S., Villain C., Vilaire-Meunier M. E., Villar-Garcia J., Vincent A., Volokha A., Vuotto F., Wauters E., Wauters J., Wu A. K. L., Wu T. -C., Yahsi A., Yesilbas O., Yildiz M., Young B. E., Yukselmis U., Zecca M., Zuccaro V., Van Praet J., Lambrecht B. N., Van Braeckel E., Bosteels C., Hoste L., Hoste E., Bauters F., De Clercq J., Heijmans C., Slabbynck H., Naesens L., Florkin B., Boulanger C., Vanderlinden D., Berkell M., Carelli V., Malhotra S., Mattiaccio A., Pippucci T., Seri M., Tacconelli E., van Agtmael M., Algera A. G., Appelman B., van Baarle F., Bax D., Beudel M., Bogaard H. J., Bomers M., Bonta P., Bos L., Botta M., de Brabander J., de Bree G., de Bruin S., Buis D. T. P., Bugiani M., Bulle E., Cloherty O. C. A., Dijkstra M., Dongelmans D. A., Dujardin R. W. G., Elbers P., Fleuren L., Geijtenbeek S. G. T., Girbes A., Goorhuis B., Grobusch M. P., Hafkamp F., Hagens L., Hamann J., Harris V., Hemke R., Heunks S. M. H. L., Hollmann M., Horn J., Hovius J. W., de Jong M. D., Koning R., Lim E. H. T., van Mourik N., Nellen J., Nossent E. J., Paulus F., Peters E., Pina-Fuentes D. A. I., van der Poll T., Preckel B., Prins J. M., Raasveld J., Reijnders T., de Rotte M. C. F. J., Schinkel M., Schultz M. J., Schrauwen F. A. P., Schuurmans A., Schuurmans J., Sigaloff K., Slim M. A., Smeele P., Smit M., Stijnis C. S., Stilma W., Teunissen C., Thoral P., Tsonas A. M., Tuinman P. R., van der Valk M., Veelo D., Volleman C., de Vries H., Vught L. A., van Vugt M., Wouters D., Zwinderman A. H., Brouwer M. C., Wiersinga W. J., Vlaar A. P. J., Tompkins M. F., Alba C., Hupalo D. N., Rosenberger J., Sukumar G., Wilkerson M. D., Zhang X., Lack J., Oler A. J., Dobbs K., Danielson J. J., Biondi A., Bettini L. R., D'Angio' M., Beretta I., Imberti L., Sottini A., Quaresima V., Quiros-Roldan E., Rossi C., Meyts I., Zhang S. -Y., Puel A., Notarangelo L. D., Boisson-Dupuis S., Su H. C., Boisson B., Jouanguy E., Zhang Q., Abel L., and Cobat A.
Abstract: Background: We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods: We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results: No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5–528.7, P = 1.1 × 10−4) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3–8.2], P = 2.1 × 10−4). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1–2635.4], P = 3.4 × 10−3), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3–8.4], P = 7.7 × 10−8). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10−5). Conclusions: Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.
Published: 2023

16. Optimising the acid-base ratio of Mg-Al layered double oxides to enhance CO2 capture performance: the critical role of calcination conditions.

Author: Leung, D. W. Justin, Laney, Katherine R., Kenyon, Philip, Rees, Nicholas H., Buffet, Jean-Charles, Chunping Chen, and O'Hare, Dermot
Subjects: *SURFACE properties, *OXIDES, *SURFACE area
Abstract: The effect of calcination conditions (ramp rate, calcination temperature and time) on the formation of Mg2Al layered double oxides (Mg2Al LDOs) as well as their CO2 capture performance, has been systematically investigated. This study explores novel insights into the intricate relationship between these calcination conditions and the resulting surface characteristics, which play a vital role in CO2 capture efficiency. Notably, it is revealed that a rapid ramp rate (100 ℃ min-1) significantly increases surface area and hydroxyl concentration, leading to a 69% increase in CO2 capture efficiency compared to slower ramp rate. Conversely, short calcination times (1 h) and fast ramp rates (100 ℃ min-1) are observed to compromise CO2 adsorption due to the presence of dehydrated LDHs. A critical acid: base ratio of 0.37, achieved from a fast ramp rate (100 ℃ min-1) at 400 ℃ for 2 h, was found as a key threshold for optimising surface properties, effectively balancing favourable hydroxyl and less favourable strong acid sites, thereby maximizing CO2 capture performance. [ABSTRACT FROM AUTHOR]
Published: 2024
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17. Chinese family care partners of older adults in Canada have grit: A qualitative study.

Author: Leung, D. Y. L., Lee, C. T., Chu, S. Y. J., Ng, F., Wen, P., Fan, J., Cheung, D. S. K., Nielsen, L. Seto, Guruge, S., and Wong, J.
Subjects: *HEALTH services accessibility, *COMMUNITY health services, *QUALITATIVE research, *RESEARCH funding, *SPOUSES, *INTERVIEWING, *FAMILY roles, *JUDGMENT sampling, *SOCIAL case work, *SOUND recordings, *THEMATIC analysis, *RESEARCH methodology, *DATA analysis software, *CAREGIVER attitudes
Abstract: Aim: To explain the process taken by Chinese family care partners of older adults in the Greater Toronto Area, Canada, to access health and social services in their communities. The research question was: What mechanisms and structures impact the agency of Chinese family care partners of older adults, in the process of assisting them to access health and social services? Design: This qualitative study was informed by critical realism. Methods: Chinese family care partners of older adults in the Greater Toronto Area, Canada, were interviewed from August 2020 to June 2021. Transcripts underwent thematic analysis. Findings: Twenty-eight Chinese family care partners expressed a firm commitment to maintain caregiving conditions and to judiciously access health and social services. Their commitment was made up of three parts: (a) legislative and cultural norms of family, work, and society; (b) their perseverance to fill gaps with limited social and financial resources; (c) the quality of their relationship to, and illness trajectory of the older adults. The social structures created tension in how Chinese family care partners made decisions, negotiated resources, and ultimately monitored and coordinated timely access with older adults. Conclusion: Participants' commitment and perseverance were conceptualized as "grit," central to their agency to conform to legislative and cultural norms. Moreover, findings support grit's power to motivate and sustain family caregiving, in order for older adults to age in place as long as possible with finite resources. Implications for the profession: This study highlights the importance of cultural awareness education for nurses, enabling continuity of care at a systems level and for a more resilient healthcare system. Impact: Family care partners' grit may be crucial for nurses to harness when together, they face limited access to culturally appropriate health and social services in a system grounded in values of equity and inclusion, as in Canada. Reporting method: When writing this manuscript, we adhered to relevant EQUATOR guidelines of the Consolidated Criteria for Reporting Qualitative Research (COREQ). Patient or public involvement and engagement: No patient or public involvement. [ABSTRACT FROM AUTHOR]
Published: 2024
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18. 144 Dupilumab restores the equilibrium of keratins and desmosomal components, integral components of the skin barrier cornified envelope

Author: Goleva, E., primary, Berdyshev, E., additional, Kreimer, S., additional, Bronova, I., additional, Lyubchenko, T., additional, Bafna, S., additional, Agueusop, I., additional, Bissonnette, R., additional, Zahn, J., additional, Zhang, A., additional, and Leung, D., additional
Published: 2023
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19. Chinese family care partners of older adults in Canada have grit: A qualitative study

Author: Leung, D. Y. L., primary, Lee, C. T., additional, Chu, S. Y. J., additional, Ng, F., additional, Wen, P., additional, Fan, J., additional, Cheung, D. S. K., additional, Seto Nielsen, L., additional, Guruge, S., additional, and Wong, J., additional
Published: 2023
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20. Dosimetric Plan Evaluation of Biology Guided Radiotherapy Using [18F]-DCFPyL PSMA Radiotracer in Patients with Prostate Cancer

Author: Liu, B., primary, Chen, Q., additional, Qing, K., additional, Dandapani, S.V., additional, Li, Y.R., additional, Glaser, S.M., additional, Chen, H.K., additional, Da Silva, A., additional, Leung, D., additional, Feghali, K. A. Al, additional, Simpson, J., additional, Liu, J., additional, Dorff, T.B., additional, Liu, A., additional, Williams, T.M., additional, and Wong, J.Y.C., additional
Published: 2023
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21. P288 Defining clinical endpoints in limb girdle muscular dystrophy D1-DNAJB6-related: a GRASP consortium study

Author: Findlay, A., primary, Hunn, S., additional, Alfano, L., additional, Lowes, L., additional, Wicklund, M., additional, Leung, D., additional, Jones, A., additional, Butler, A., additional, Hayes, M., additional, Sasidhara, S., additional, Holzer, M., additional, Stinson, N., additional, Seiffert, M., additional, Statland, J., additional, Johnson, N., additional, and Weihl, C., additional
Published: 2023
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22. Pilot Study of a Novel Ring Gantry-Based PET/CT Linear Accelerator in Patients with Prostate Cancer Receiving [18F]-DCFPyL for PSMA PET Imaging

Author: Wong, J.Y.C., primary, Liu, B., additional, Dandapani, S.V., additional, Li, Y.R., additional, Glaser, S.M., additional, Liu, J., additional, Chen, Q., additional, Qing, K., additional, Chen, H.K., additional, Simpson, J., additional, Da Silva, A., additional, Leung, D., additional, Feghali, K., additional, Dorff, T.B., additional, Liu, A., additional, and Williams, T.M., additional
Published: 2023
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23. Evaluation of 68Ga-Fibroblast Activation Protein Inhibitor vs. 18F-FDG as a Novel Radiotracer for Biologically Guided Radiation Therapy

Author: Qiu, L., primary, Chen, Y., additional, Williams, T.M., additional, Amini, A., additional, Sampath, S., additional, Glaser, S.M., additional, Chen, Y.J., additional, Liu, L., additional, Leung, D., additional, Liu, A., additional, and McGee, H.M., additional
Published: 2023
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24. P292 Clinical outcome assessments in limb girdle muscular dystrophy R1/2A: a longitudinal update

Author: Hunn, S., primary, Alfano, L., additional, Lowes, L., additional, Wicklund, M., additional, Mathews, K., additional, Mozaffar, T., additional, Leung, D., additional, Jones, A., additional, Butler, A., additional, Hayes, M., additional, Sasidharan, S., additional, Reash, N., additional, Iammarino, M., additional, Laubscher, K., additional, Mockler, S., additional, Ausberger, R., additional, Holzer, M., additional, Stinson, N., additional, Seiffert, M., additional, Statland, J., additional, Johnson, N., additional, and Weihl, C., additional
Published: 2023
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25. The Universal Composable Security of Quantum Key Distribution

Author: Ben-Or, M., Horodecki, Michal, Leung, D. W., Mayers, D., and Oppenheim, J.
Subjects: Quantum Physics
Abstract: The existing unconditional security definitions of quantum key distribution (QKD) do not apply to joint attacks over QKD and the subsequent use of the resulting key. In this paper, we close this potential security gap by using a universal composability theorem for the quantum setting. We first derive a composable security definition for QKD. We then prove that the usual security definition of QKD still implies the composable security definition. Thus, a key produced in any QKD protocol that is unconditionally secure in the usual definition can indeed be safely used, a property of QKD that is hitherto unproven. We propose two other useful sufficient conditions for composability. As a simple application of our result, we show that keys generated by repeated runs of QKD degrade slowly.
Published: 2004

26. Asymptotic entanglement capacity of the Ising and anisotropic Heisenberg interactions

Author: Childs, A. M., Leung, D. W., Verstraete, F., and Vidal, G.
Subjects: Quantum Physics
Abstract: We compute the asymptotic entanglement capacity of the Ising interaction ZZ, the anisotropic Heisenberg interaction XX + YY, and more generally, any two-qubit Hamiltonian with canonical form K = a XX + b YY. We also describe an entanglement assisted classical communication protocol using the Hamiltonian K with rate equal to the asymptotic entanglement capacity., Comment: 5 pages, 1 figure; minor corrections, conjecture added
Published: 2002
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27. On the capacities of bipartite Hamiltonians and unitary gates

Author: Bennett, C. H., Harrow, A. W., Leung, D. W., and Smolin, J. A.
Subjects: Quantum Physics
Abstract: We consider interactions as bidirectional channels. We investigate the capacities for interaction Hamiltonians and nonlocal unitary gates to generate entanglement and transmit classical information. We give analytic expressions for the entanglement generating capacity and entanglement-assisted one-way classical communication capacity of interactions, and show that these quantities are additive, so that the asymptotic capacities equal the corresponding 1-shot capacities. We give general bounds on other capacities, discuss some examples, and conclude with some open questions., Comment: V3: extensively rewritten. V4: a mistaken reference to a conjecture by Kraus and Cirac [quant-ph/0011050] removed and a mistake in the order of authors in Ref. [53] corrected
Published: 2002
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28. Choi's Proof and Quantum Process Tomography

Author: Leung, D. W.
Subjects: Quantum Physics
Abstract: Quantum process tomography is a procedure by which an unknown quantum operation can be fully experimentally characterized. We reinterpret Choi's proof of the fact that any completely positive linear map has a Kraus representation [Lin. Alg. and App., 10, 1975] as a method for quantum process tomography. Furthermore, the analysis for obtaining the Kraus operators are particularly simple in this method., Comment: submitted to special issue of JMP on QIT
Published: 2002
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29. Oblivious remote state preparation

Author: Leung, D. W. and Shor, P. W.
Subjects: Quantum Physics
Abstract: We consider remote state preparation protocols for a set of pure states whose projectors form a basis for operators acting on the input Hilbert space. If a protocol (1) uses only forward communication and entanglement, (2) deterministically prepares an exact copy of the state, and (3) does so obliviously -- without leaking further information about the state to the receiver -- then the protocol can be modified to require from the sender only a single specimen of the state. Furthermore, the original protocol and the modified protocol use the same amount of classical communication. Thus, under the three conditions stated, remote state preparation requires at least as much classical communication as teleportation, as Lo has conjectured [PRA 62 (2000) 012313], which is twice the expected classical communication cost of some existing nonoblivious protocols.
Published: 2002
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30. Two-qubit Projective Measurements are Universal for Quantum Computation

Author: Leung, D. W.
Subjects: Quantum Physics
Abstract: Nielsen [quant-ph/0108020] showed that universal quantum computation is possible given quantum memory and the ability to perform projective measurements on up to 4-qubits. We describe an improved method that requires only 2-qubit measurements, which are both sufficient and necessary. We present a method to partially collapse the $C_k$-hierarchy in the indirect construction of unitary gates [Gottesman and Chuang, Nature, {\bf 402} 309 (1999)], and apply the method to find discrete universal sets of 2-qubit measurements., Comment: Results and discussed expanded, simple discrete universal sets of measurements presented
Published: 2001

31. Simulation and reversal of n-qubit Hamiltonians using Hadamard matrices

Author: Leung, D. W.
Subjects: Quantum Physics
Abstract: The ability to simulate one Hamiltonian with another is an important primitive in quantum information processing. In this paper, a simulation method for arbitrary $\sigma_z \otimes \sigma_z$ interaction based on Hadamard matrices (quant-ph/9904100) is generalized for any pairwise interaction. We describe two applications of the generalized framework. First, we obtain a class of protocols for selecting an arbitrary interaction term in an n-qubit Hamiltonian. This class includes the scheme given in quant-ph/0106064v2. Second, we obtain a class of protocols for inverting an arbitrary, possibly unknown n-qubit Hamiltonian, generalizing the result in quant-ph/0106085v1., Comment: Critical mistake corrected, conclusions essentially unchanged
Published: 2001
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32. Optimal simulation of two-qubit Hamiltonians using general local operations

Author: Bennett, C. H., Cirac, J. I., Leifer, M. S., Leung, D. W., Linden, N., Popescu, S., and Vidal, G.
Subjects: Quantum Physics
Abstract: We consider the simulation of the dynamics of one nonlocal Hamiltonian by another, allowing arbitrary local resources but no entanglement nor classical communication. We characterize notions of simulation, and proceed to focus on deterministic simulation involving one copy of the system. More specifically, two otherwise isolated systems $A$ and $B$ interact by a nonlocal Hamiltonian $H \neq H_A+H_B$. We consider the achievable space of Hamiltonians $H'$ such that the evolution $e^{-iH't}$ can be simulated by the interaction $H$ interspersed with local operations. For any dimensions of $A$ and $B$, and any nonlocal Hamiltonians $H$ and $H'$, there exists a scale factor $s$ such that for all times $t$ the evolution $e^{-iH'st}$ can be simulated by $H$ acting for time $t$ interspersed with local operations. For 2-qubit Hamiltonians $H$ and $H'$, we calculate the optimal $s$ and give protocols achieving it. The optimal protocols do not require local ancillas, and can be understood geometrically in terms of a polyhedron defined by a partial order on the set of 2-qubit Hamiltonians., Comment: (1) References to related work, (2) protocol to simulate one two-qudit Hamiltonian with another, and (3) other related results added. Some proofs are simplified
Published: 2001
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33. Quantum Vernam Cipher

Author: Leung, D. W.
Subjects: Quantum Physics
Abstract: We discuss aspects of secure quantum communication by proposing and analyzing a quantum analog of the Vernam cipher (one-time-pad). The quantum Vernam cipher uses entanglement as the key to encrypt quantum information sent through an insecure quantum channel. First, in sharp contrast with the classical Vernam cipher, the quantum key can be recycled securely. We show that key recycling is intrinsic to the quantum cipher-text, rather than using entanglement as the key. Second, the scheme detects and corrects for arbitrary transmission errors, and it does so using only local operations and classical communication (LOCC) between the sender and the receiver. The application to quantum message authentication is discussed. Quantum secret sharing schemes with similar properties are characterized. We also discuss two general issues, the relation between secret communication and secret sharing, the classification of secure communication protocols., Comment: stronger security proof for recycling classical keys
Published: 2000

34. Physiological and biological thinking in late nineteenth-century English medicine with reference to Clifford Allbutt

Author: Leung, D. C. K.
Subjects: 610.9
Abstract: Individual physicians' medical thinking is one of the aspects which has not been fully explored in the present historiography of English medicine. In this thesis, I examine the medical thought of Clifford Allbutt who was Regius Professor of Physic at Cambridge University from 1892 to 1925. He was the designer of the 3-inch thermometer that we use today and was an advocate of the use of the ophthalmoscope in general medicine, the integration of medicine with surgery and the basic sciences, the physiological concept of disease, and comparative pathology. I argue that all these projects were concerted efforts to make medicine a biological science and they were guided by Allbutt's physiological and biological thinking. I examine Allbutt's medical thinking under three headings: (1) medical generalism, (2) the concept of disease, and (3) comparative pathology. In chapter two, I discuss how Allbutt attempted to make late nineteenth-century English clinical medicine an on-going research enterprise, through his own experience in ophthalmic and thermometric research. In chapter three, I discuss Allbutt's protest against the divorce of physic and surgery and his advocacy of the hospital unit system. My discussions in these two chapters will explain Allbutt's medical generalism. Chapter four looks at Allbutt's criticism of the concept of disease as a morbid entity and his argument for the physiological notion. I explore the historical background of Allbutt's view and explain how he used history to support his claims. Chapter five is devoted to Allbutt's advocacy of comparative pathology. I explain Allbutt's criticism of what he called 'anthropocentric medicine' and discuss how he integrated medicine and biology with an evolutionist framing of comparative pathology. Through my discussion, Allbutt's achievements can be understood in a new light and I also aim to complement the received image of scientific medicine with a more biologically focused character.
Published: 2007

35. On the complemented subspaces of the Schreier spaces

Author: Gasparis, I. and Leung, D. H.
Subjects: Mathematics - Functional Analysis, 46B03
Abstract: It is shown that the Schreier space X admits a set of continuum cardinality whose elements are mutually incomparable complemented subspaces spanned by subsequences of the natural Schauder basis of X., Comment: 26 pages, AMS-LaTeX
Published: 1999

36. The development of a reference database with the Topcon 3D OCT-1 Maestro

Author: Chaglasian M, Fingeret M, Davey PG, Huang WC, Leung D, Ng E, and Reisman CA
Subjects: Spectral domain optical coherence tomography, normal eyes, Ophthalmology, RE1-994
Abstract: Michael Chaglasian,1 Murray Fingeret,2 Pinakin Gunvant Davey,3 Wei-Chieh Huang,4 Danny Leung,4 Edmund Ng,5 Charles A Reisman4 1Illinois Eye Institute, Illinois College of Optometry, Chicago, IL, USA; 2Department of Veterans Affairs, New York Harbor Health Care System, Brooklyn, NY, USA; 3School of Optometry, Western University of Health Sciences, Pomona, CA, USA; 4Topcon Healthcare Solutions Research and Development, Oakland, NJ, USA; 5Edmund Ng Consulting, LLC, Seattle, WA, USA Importance: The paper presents the range for measurements taken with a new spectral domain optical coherence tomography (OCT) device to establish a reference database for discrimination purposes. Objective: To report the range of thickness values for the new Topcon Maestro 3D OCT device with 2 scan size settings: the 12×9 mm wide field and 6×6 mm scans. Design: Prospective, multicenter cohort study conducted at 7 clinical sites across the USA. Setting: Primary eyecare clinics within academic, hospital, and private practice locations. Participants: Healthy volunteers; all enrolled participants underwent a complete ophthalmological examination to confirm healthy ocular status prior to being enrolled in the study. Main outcome measure: Average and 1st, 5th, 95th, and 99th percentile ranges for OCT parameters Early Treatment Diabetic Retinopathy Study macula full retinal thickness, ganglion cell + inner plexiform layer thickness (GCL + IPL), ganglion cell complex (GCC) thickness, circumpapillary retinal nerve fiber layer (cpRNFL) thickness. Results: Three hundred and ninety-nine eyes of 399 subjects were included in the analysis. Mean (SD) age was 46.3 (16.3) years (range 18–88 years). Forty-three percent of the subjects were male. Mean (SD) measurements (in μm) for the 12×9 mm wide scan were as follows: foveal thickness=237.079 (20.899), GCL + IPL=71.363 (5.924), GCC=105.949 (8.533), cpRNFL=104.720 (11.829); measurements for the 6×6 mm scans were as follows: foveal thickness=234.000 (20.657), GCL + IPL=71.726 (5.880), GCC=106.698 (9.094), cpRNFL=104.036 (11.341). Conclusion: The overall normal thickness values reported with Topcon 3D OCT-1 Maestro were like those studies with OCT from different manufactures. The reference limits at the 1st, 5th, 95th, and 99th percentile points establish the thresholds for the quantitative comparison of the cpRNFL and the macula in the human retina to a database of known healthy subjects. Keywords: spectral domain optical coherence tomography, normal eyes, 3D OCT-1 Maestro, macular measurements, circumpapillary retinal nerve fiber layer, optic disc
Published: 2018

37. Joint spatial time-series epidemiological analysis of malaria and cutaneous leishmaniasis infection

Author: ADEGBOYE, O. A., AL-SAGHIR, M., and LEUNG, D. H. Y.
Published: 2017

38. Coronary Artery Perforation (CAP) During Stenting: 20-Year Experience in South Western Sydney Local Health District

Author: Dang, V., primary, Rajaratnam, D., additional, Boddupalli, S., additional, Pender, P., additional, Leung, J., additional, Asrress, K., additional, Kachwalla, H., additional, Rajaratnam, R., additional, Leung, D., additional, and Lo, S., additional
Published: 2023
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39. Long-Term Outcomes of Percutaneous Coronary Intervention (PCI) With Intravascular Lithotripsy (IVL) With Predictors of Cardiovascular Outcomes

Author: Leung, J., primary, Pender, P., additional, French, J., additional, Leung, D., additional, Mussap, C., additional, Asrress, K., additional, Taylor, D., additional, Badie, T. Naguib, additional, Kaddapu, K., additional, Gibbs, O., additional, Kachwalla, H., additional, Hopkins, A., additional, and Lo, S., additional
Published: 2023
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40. Complex Percutaneous Coronary Intervention (PCI) in Diabetics Requiring Intravascular Lithotripsy (IVL)—Long-Term Outcomes in a Single Centre

Author: Leung, J., primary, Pender, P., additional, French, J., additional, Leung, D., additional, Mussap, C., additional, Asrress, K., additional, Taylor, D., additional, Badie, T. Naguib, additional, Kaddapu, K., additional, Gibbs, O., additional, Kachwalla, H., additional, Hopkins, A., additional, and Lo, S., additional
Published: 2023
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41. Impact of COVID-19 snd Societal Lockdown on Percutaneous Coronary Intervention (PCI) in Patients With ST Segment Elevation Myocardial Infarction (STEMI): A Single-Centre Study

Author: Dang, V., primary, Rajaratnam, D., additional, Sarker, A., additional, Pender, P., additional, Leung, J., additional, Juergens, C., additional, Hopkins, A., additional, Leung, D., additional, Lo, S., additional, and Rajaratnam, R., additional
Published: 2023
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42. Impact of Language Barriers During COVID-19 in ST Elevation Myocardial Infarction (STEMI) Presentation and Outcomes: A Single Centre Study

Author: Rajaratnam, D., primary, Dang, V., additional, Sarker, A., additional, Pender, P., additional, Leung, J., additional, Hopkins, A., additional, Leung, D., additional, Juergens, C., additional, Lo, S., additional, and Rajaratnam, R., additional
Published: 2023
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43. Cardiac Perforation by Temporary Transvenous Pacing Wires (TPW): Incidence and Risk Factors

Author: Nguyen, K., primary, Dang, V., additional, Towney, A., additional, Mian, M., additional, Cho, K., additional, Wales, K., additional, Pender, P., additional, Rajaratnam, R., additional, Parr, M., additional, Dimitri, H., additional, Lo, S., additional, and Leung, D., additional
Published: 2023
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44. Approximate quantum error correction can lead to better codes

Author: Leung, D. W., Nielsen, M. A., Chuang, I. L., and Yamamoto, Y.
Subjects: Quantum Physics
Abstract: We present relaxed criteria for quantum error correction which are useful when the specific dominant noise process is known. These criteria have no classical analogue. As an example, we provide a four-bit code which corrects for a single amplitude damping error. This code violates the usual Hamming bound calculated for a Pauli description of the error process, and does not fit into the GF(4) classification., Comment: 7 pages, 2 figures, submitted to Phys. Rev. A
Published: 1997
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45. Glaucoma secondary to vascular changes in optic nerve head, retina, and choroid: abridged secondary publication.

Author: Tham, C. C. Y., Chan, P. P. M., Cheung, C. Y. L., Leung, D. Y. L., Chan, N. C. Y., and Chow, C. W. Y.
Published: 2024

46. When Teaching and Volunteering Go Together: Exploring Participation Characteristics and Demographic Backgrounds of Senior Volunteer Teachers and Their Teaching Satisfaction

Author: Leung, D. D. M.
Abstract: Senior volunteer teachers play important roles in learning programmes for the elderly. These volunteers' level of teaching satisfaction was assumed to influence programmes, their organizational behaviours and outcomes. However, scant research has focused specifically on volunteers' levels of satisfaction with teaching and how their satisfaction is influenced by participation characteristics and their demographic backgrounds. This initial study conducted in Hong Kong attempts to examine this topic. Data from 236 samples from 56 units across the territory were utilized in this study. The results showed that the overall level of teaching satisfaction among senior volunteer teachers was quite high. Senior volunteer teachers with longer teaching experience and teachers with longer service felt satisfied in many areas of teaching. Teachers who taught a greater number of subjects experienced less satisfaction. A "u-shaped" trend of satisfaction correlated with the number of classes taught; senior volunteer teachers teaching 1-2 classes and volunteers teaching 6 or more classes exhibited higher satisfaction levels in various areas. The number of average teaching hours per week could simultaneously facilitate and hinder different facets of satisfaction. Female teachers experienced higher levels of "Recognition" than male counterparts. Older senior volunteer teachers were quite satisfied in the areas of "Working Conditions" and "Authority." Findings of multiple regression were discussed.
Published: 2016
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47. A brain detoxifying enzyme for organophosphorus nerve poisons

Author: Nomura, D K, Leung, D, Chiang, K P, Quistad, G B, Cravatt, B F, and Casida, J E
Subjects: detoxification, insecticide, phosphorylation, serine hydrolase KIAA1363
Abstract: Organophosphorus (OP) insecticides and chemical warfare agents act primarily by inhibiting acetylcholinesterase. There are many secondary targets for OP toxicants as observed for example with the major insecticide chlorpyrifos and its bioactivated metabolite chlorpyrifos oxon (CPO). Therefore, it was surprising that the predominant mouse brain protein labeled in vitro by [H-3-ethyl]CPO (1 nM) (designated CPO-binding protein or CPO-BP) is not one of these known OP toxicant targets. CPO-BP is a 50-kDa membrane-bound serine hydrolase measured by derivatization with [H-3]CPO and SDS/PAGE or filtration binding assay. It appears to undergo rapid cliethylphosphorylation by [H-3]CPO followed by either dephosphorylation and reactivation or aging on loss of an ethyl group. CPO and several other OP toxicants potently inhibit CPO-BP in vivo (i.p., 2 h) (50% inhibition at 2-25 mg/kg) and in vitro (50% inhibition at 8-68 nM). Using three chemical labeling reagents, i.e., [3H]CPO and the activity-based proteomic probes fluorophosphonate-biotin and fluorophosphonate-rhodamine, mouse brain CPO-BP is identified as serine hydrolase KIAA1363 of unknown function. Brains from KIAA1363(-/-) mice show greatly reduced levels of CPO labeling and hydrolytic metabolism compared to brains from wild-type mice. KIAA1363 therefore is the principal enzyme for metabolizing low levels of CPO in brain and may play a more general role in detoxification of OP nerve poisons.
Published: 2005

48. Bulk Quantum Computation with Nuclear Magnetic Resonance: Theory and Experiment

Author: Chuang, I. L., Gershenfeld, N., Kubinec, M. G., and Leung, D. W.
Published: 1998

49. Beyond death and dying: how Chinese spouses navigate the final days with their loved ones suffering from terminal cancer

Author: Chung, B. P. M., Leung, D., Leung, S. M., and Loke, A. Y.
Published: 2018
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50. 1624 Phenotypic and endotypic determinants of atopic dermatitis severity from the ADRN registry

Author: Simpson, E., primary, De Benedetto, A., additional, Boguniewicz, M., additional, Ong, P., additional, Lussier, S., additional, Villarreal, M., additional, Schneider, L., additional, Paller, A., additional, Guttman-Yassky, E., additional, Hanifin, J., additional, Spergel, J., additional, Barnes, K., additional, David, G., additional, Leung, D., additional, and Beck, L., additional
Published: 2023
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