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30 results on '"Leung, Rufina"'

1. Plasma proteins predict conversion to dementia from prodromal disease

Author

Hye, Abdul, Riddoch-Contreras, Joanna, Baird, Alison L., Ashton, Nicholas J., Bazenet, Chantal, Leung, Rufina, Westman, Eric, Simmons, Andrew, Dobson, Richard, Sattlecker, Martina, Lupton, Michelle, Lunnon, Katie, Keohane, Aoife, Ward, Malcolm, Pike, Ian, Zucht, Hans Dieter, Pepin, Danielle, Zheng, Wei, Tunnicliffe, Alan, Richardson, Jill, Gauthier, Serge, Soininen, Hilkka, Kłoszewska, Iwona, Mecocci, Patrizia, Tsolaki, Magda, Vellas, Bruno, and Lovestone, Simon

Published
2014
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3. Association of Plasma Clusterin Concentration With Severity, Pathology, and Progression in Alzheimer Disease

Author

Thambisetty, Madhav, Simmons, Andrew, Velayudhan, Latha, Hye, Abdul, Campbell, James, Zhang, Yi, Wahlund, Lars-Olof, Westman, Eric, Kinsey, Anna, Güntert, Andreas, Proitsi, Petroula, Powell, John, Causevic, Mirsada, Killick, Richard, Lunnon, Katie, Lynham, Steven, Broadstock, Martin, Choudhry, Fahd, Howlett, David R., Williams, Robert J., Sharp, Sally I., Mitchelmore, Cathy, Tunnard, Catherine, Leung, Rufina, Foy, Catherine, O’Brien, Darragh, Breen, Gerome, Furney, Simon J., Ward, Malcolm, Kloszewska, Iwona, Mecocci, Patrizia, Soininen, Hilkka, Tsolaki, Magda, Vellas, Bruno, Hodges, Angela, Murphy, Declan G., Parkins, Sue, Richardson, Jill C., Resnick, Susan M., Ferrucci, Luigi, Wong, Dean F., Zhou, Yun, Muehlboeck, Sebastian, Evans, Alan, Francis, Paul T., Spenger, Christian, and Lovestone, Simon

Published
2010

5. Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly

Author

Westwood, Sarah, Leoni, Emanuela, Hye, Abdul, Lynham, Steven, Khondoker, Mizanur R, Ashton, Nicholas J, Kiddle, Steven J, Baird, Alison L, Sainz-Fuertes, Ricardo, Leung, Rufina, Graf, John, Hehir, Cristina Tan, Baker, David, Cereda, Cristina, Bazenet, Chantal, Ward, Malcolm, Thambisetty, Madhav, Lovestone, Simon, Kiddle, Steven [0000-0003-4350-7437], and Apollo - University of Cambridge Repository

Subjects
Brain Chemistry, Male, Aniline Compounds, KeywordsAlzheimer’s disease, amyloid, Brain, Amyloidogenic Proteins, Thiazoles, proteomics, blood, Alzheimer Disease, Tandem Mass Spectrometry, Positron-Emission Tomography, preclinical, Humans, Female, alpha-Macroglobulins, Benzothiazoles, biological markers, plasma, Biomarkers, Aged
Abstract

Increasingly, clinical trials for Alzheimer's disease (AD) are being conducted earlier in the disease phase and with biomarker confirmation using in vivo amyloid PET imaging or CSF tau and Aβ measures to quantify pathology. However, making such a pre-clinical AD diagnosis is relatively costly and the screening failure rate is likely to be high. Having a blood-based marker that would reduce such costs and accelerate clinical trials through identifying potential participants with likely pre-clinical AD would be a substantial advance. In order to seek such a candidate biomarker, discovery phase proteomic analyses using 2DGE and gel-free LC-MS/MS for high and low molecular weight analytes were conducted on longitudinal plasma samples collected over a 12-year period from non-demented older individuals who exhibited a range of 11C-PiB PET measures of amyloid load. We then sought to extend our discovery findings by investigating whether our candidate biomarkers were also associated with brain amyloid burden in disease, in an independent cohort. Seven plasma proteins, including A2M, Apo-A1, and multiple complement proteins, were identified as pre-clinical biomarkers of amyloid burden and were consistent across three time points (p < 0.05). Five of these proteins also correlated with brain amyloid measures at different stages of the disease (q < 0.1). Here we show that it is possible to detect a plasma based biomarker signature indicative of AD pathology at a stage long before the onset of clinical disease manifestation. As in previous studies, acute phase reactants and inflammatory markers dominate this signature.

Published
2018
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6. IDENTIFICATION OF CLINICAL FEATURES THAT PREDICT FUTURE WEIGHT TRAJECTORY IN A NOVEL COHORT OF CLOZAPINE-TREATED PATIENTS

Author

Harrison, Rebecca, primary, Breen, Gerome, additional, Couchman, Lewis, additional, Socrates, Adam, additional, Akingbuwa, Omowonuola, additional, Coulson, Alice, additional, Dempster, David, additional, Leung, Rufina, additional, Xu, Xiaohui, additional, Fisher, Danielle, additional, Subramaniam, Krithika, additional, and Flanagan, Robert, additional

Published
2019
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7. Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

Author

Eating Disorder Working Group of the Psychiatric Genomics Consortium, Huckins, Laura M., Hatzikotoulas, Konstantinos, Southam, Lorraine, Thornton, Laura M., Steinberg, Julia, Mckay Aguilera, Fernando Riveros, Treasure, Janet, Schmidt, Ulrike, Gunasinghe, Cerisse, Romero, Anibal, Curtis, Charles, Rhodes, Daniel, Moens, Julie, Kalsi, Gursharan, Dempster, David, Leung, Rufina, Keohane, Aoife, Burghardt, Roland, Ehrlich, Stefan, Hebebrand, Johannes, Hinney, Anke, Ludolph, Anja, Walton, Esther, Deloukas, Panos, Hofman, Albert, Palotie, Aarno, Palta, Priit, Rooij, Frank J. A. van, Stirrups, Kathleen, Adan, Roger, Boni, Claudette, Cone, Roger, Dedoussis, George, Furth, Eric van, Gonidakis, Fragiskos, Gorwood, Philip, Hudson, James I., Kaprio, Jaakko, Kas, Martien, Keski-Rahkonen, Anna, Kiezebrink, Kirsty, Knudsen, Gun Peggy, Slof-Op ‘t Landt, Margarita C. T., Maj, Mario, Monteleone, Alessio Maria, Monteleone, Palmiero, Raevuori, Anu, Reichborn-Kjennerud, Ted, Tozzi, Federica, Tsitsika, Artemis, Elburg, Annemarie van, Collier, David A., Sullivan, Patrick F., Breen, Gerome, Bulik, Cynthia M., Zeggini, Eleftheria, Eating Disorder Working Group of the Psychiatric Genomics Consortium, Huckins, Laura M., Hatzikotoulas, Konstantinos, Southam, Lorraine, Thornton, Laura M., Steinberg, Julia, Mckay Aguilera, Fernando Riveros, Treasure, Janet, Schmidt, Ulrike, Gunasinghe, Cerisse, Romero, Anibal, Curtis, Charles, Rhodes, Daniel, Moens, Julie, Kalsi, Gursharan, Dempster, David, Leung, Rufina, Keohane, Aoife, Burghardt, Roland, Ehrlich, Stefan, Hebebrand, Johannes, Hinney, Anke, Ludolph, Anja, Walton, Esther, Deloukas, Panos, Hofman, Albert, Palotie, Aarno, Palta, Priit, Rooij, Frank J. A. van, Stirrups, Kathleen, Adan, Roger, Boni, Claudette, Cone, Roger, Dedoussis, George, Furth, Eric van, Gonidakis, Fragiskos, Gorwood, Philip, Hudson, James I., Kaprio, Jaakko, Kas, Martien, Keski-Rahkonen, Anna, Kiezebrink, Kirsty, Knudsen, Gun Peggy, Slof-Op ‘t Landt, Margarita C. T., Maj, Mario, Monteleone, Alessio Maria, Monteleone, Palmiero, Raevuori, Anu, Reichborn-Kjennerud, Ted, Tozzi, Federica, Tsitsika, Artemis, Elburg, Annemarie van, Collier, David A., Sullivan, Patrick F., Breen, Gerome, Bulik, Cynthia M., and Zeggini, Eleftheria

Abstract

Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls. Unlike previous studies, this GWAS also probed association in low-frequency and rare variants. Sixteen independent variants were taken forward for in silico and de novo replication (11 common and 5 rare). No findings reached genome-wide significance. Two notable common variants were identified: rs10791286, an intronic variant in OPCML (P=9.89 × 10−6), and rs7700147, an intergenic variant (P=2.93 × 10−5). No low-frequency variant associations were identified at genome-wide significance, although the study was well-powered to detect low-frequency variants with large effect sizes, suggesting that there may be no AN loci in this genomic search space with large effect sizes.

Published
2017

9. Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly

Author

Westwood, Sarah, primary, Leoni, Emanuela, additional, Hye, Abdul, additional, Lynham, Steven, additional, Khondoker, Mizanur R., additional, Ashton, Nicholas J., additional, Kiddle, Steven J., additional, Baird, Alison L., additional, Sainz-Fuertes, Ricardo, additional, Leung, Rufina, additional, Graf, John, additional, Hehir, Cristina Tan, additional, Baker, David, additional, Cereda, Cristina, additional, Bazenet, Chantal, additional, Ward, Malcolm, additional, Thambisetty, Madhav, additional, and Lovestone, Simon, additional

Published
2016
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10. P4–354: Blood‐based biomarker discovery using aptamer capture (SOMAscan) platform technology

Author

Sattlecker, Martina, primary, Pritchard, Megan, additional, Proitsi, Petroula, additional, Kiddle, Steven, additional, Newhouse, Stephen, additional, Simmons, Andy, additional, Johnston, Caroline, additional, Leung, Rufina, additional, Dixit, Abhishek, additional, Bazenet, Chantal, additional, Soininen, Hilkka, additional, Kloszewska, Iwona, additional, Mecocci, Patrizia, additional, Tsolaki, Magda, additional, Vellas, Bruno, additional, Stewart, Alex, additional, Williams, Steven, additional, Nelson, Sally, additional, Lovestone, Simon, additional, and Dobson, Richard, additional

Published
2013
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11. P4-351: Peripheral signatures of the clusterin-DKK neurotoxicity pathway as potential blood-based biomarkers

Author

Lovestone, Simon, primary, Sattlecker, Martina, additional, Dixit, Abishek, additional, Kiddle, Steven, additional, Leung, Rufina, additional, Bazenet, Chantal, additional, Pritchard, Megan, additional, Soininen, Hilkka, additional, Kloszewska, Iwona, additional, Mecocci, Patrizia, additional, Tsolaki, Magda, additional, Vellas, Bruno, additional, Stewart, Alex, additional, Williams, Steven, additional, Nelson, Sally, additional, and Dobson, Richard, additional

Published
2013
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12. Inflammatory Proteins in Plasma Are Associated with Severity of Alzheimer’s Disease

Author

Leung, Rufina, primary, Proitsi, Petroula, additional, Simmons, Andrew, additional, Lunnon, Katie, additional, Güntert, Andreas, additional, Kronenberg, Deborah, additional, Pritchard, Megan, additional, Tsolaki, Magda, additional, Mecocci, Patrizia, additional, Kloszewska, Iwona, additional, Vellas, Bruno, additional, Soininen, Hilkka, additional, Wahlund, Lars-Olaf, additional, and Lovestone, Simon, additional

Published
2013
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13. The activating NKG2D ligand MHC class I-related chain a transfers from target cells to NK cells in a manner that allows functional consequences

Author

McCann, Fiona E., Eissmann, Philipp, Önfelt, Björn, Leung, Rufina, Davis, Daniel M., McCann, Fiona E., Eissmann, Philipp, Önfelt, Björn, Leung, Rufina, and Davis, Daniel M.

Abstract

Recently, it has become apparent that surface proteins commonly transfer between immune cells in contact. Inhibitory receptors and ligands exchange between cells during NK cell surveillance and we report here that NK cells also acquire activating ligands from target cells. Specifically, the stress-inducible activating ligand for NKG2D, MHC class I-related chain A (MICA), transferred to NK cells upon conjugation with MICA-expressing target cells. Acquisition of MICA from target cells was dependent on cell contact and occurred after accumulation of MICA at the immunological synapse. Moreover, transfer of MICA was facilitated by specific molecular recognition via NKG2D and augmented by Src kinase signaling. Importantly, MICA associated with its new host NK cell membrane in an orientation that allowed engagement with NKG2D in trans and indeed could down-regulate NKG2D in subsequent homotypic interactions with other NK cells. MICA captured from target cells could subsequently transfer between NK cells and, more importantly, NK cell degranulation was triggered in such NK cell-NK cell interactions. Thus, NK cells can influence other NK cells with proteins acquired from target cells and our data specifically suggest that NK cells could lyse other NK cells upon recognition of activating ligands acquired from target cells. This mechanism could constitute an important function for immunoregulation of NK cell activity., QC 20100525

Published
2007
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14. P1‐037: Plasma inflammatory markers correlate with severity in Alzheimer's disease

Author

Leung, Rufina, primary, Simmons, Andy, additional, Proitsi, Petroula, additional, Kronenberg, Deborah, additional, Pritchard, Megan, additional, Tsolaki, Magda, additional, Mecocci, Patrizia, additional, Oszewska, Iwona, additional, Vellas, Bruno, additional, Soininen, Hilkka, additional, Spenger, Christian, additional, Wahlund, Lars‐Olaf, additional, and Lovestone, Simon, additional

Published
2012
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15. Plasma Transthyretin as a Candidate Marker for Alzheimer's Disease

Author

Velayudhan, Latha, primary, Killick, Richard, additional, Hye, Abdul, additional, Kinsey, Anna, additional, Güntert, Andreas, additional, Lynham, Steven, additional, Ward, Malcolm, additional, Leung, Rufina, additional, Lourdusamy, Anbarasu, additional, To, Alvina W.M., additional, Powell, John, additional, and Lovestone, Simon, additional

Published
2012
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17. P4-114: Small Chronic Alterations in Gene Expression and Circulating Blood Cells in Alzheimer's Disease

Author

Lunnon, Katie S., primary, Sivapalan, Haran, additional, Vincent, Amanda, additional, Proitsi, Petroula, additional, Pritchard, Megan, additional, Martin, Belinda, additional, Lord, Kathryn, additional, Tunnard, Catherine, additional, Leung, Rufina, additional, Dunlop, Nicola, additional, Lovestone, Simon, additional, and Hodges, Angela, additional

Published
2010
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19. P3-221: Plasma inflammatory markers correlate with severity in Alzheimer's disease

Author

Leung, Rufina, primary, Simmons, Andy, additional, Guntert, Andreas, additional, Kronenberg, Deborah, additional, Furney, Simon J., additional, Pritchard, Megan, additional, Tsolaki, Magda, additional, Mecocci, Patrizia, additional, Kloszewska, Iwona, additional, Vellas, Bruno, additional, Soininen, Hikka, additional, Spenger, Christian, additional, Wahlund, Lars-Olaf, additional, and Lovestone, Simon, additional

Published
2010
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