14 results on '"Leung, Miriam T. Y."'
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2. Hip fracture incidence and post-fracture mortality in Victoria, Australia: a state-wide cohort study
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Leung, Miriam T. Y., Marquina, Clara, Turner, Justin P., Ilomaki, Jenni, Tran, Tim, and Bell, J. Simon
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- 2023
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3. Correction to: Hip fracture incidence and post-fracture mortality in Victoria, Australia: a state-wide cohort study
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Leung, Miriam T. Y., Marquina, Clara, Turner, Justin P., Ilomaki, Jenni, Tran, Tim, and Bell, J. Simon
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- 2023
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4. Impact of oral bisphosphonate drug holiday on mortality following hip fracture: a population-based cohort study
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Leung, Miriam T Y, primary, Turner, Justin P, additional, Marquina, Clara, additional, Ilomaki, Jenni, additional, Tran, Tim, additional, and Bell, J Simon, additional
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- 2024
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5. Effectiveness of Pharmacological Treatment for Attention-Deficit/Hyperactivity Disorder on Physical Injuries: A Systematic Review and Meta-Analysis of Observational Studies
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Man, Kenneth K. C., Ip, Patrick, Chan, Esther W., Law, Siew-ling, Leung, Miriam T. Y., Ma, Evelyn X. Y., Quek, Wan-ting, and Wong, Ian C. K.
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- 2017
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6. Trends of polypharmacy among older people in Asia, Australia and the United Kingdom: a multinational population-based study
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Lee, Hyesung, primary, Baek, Yeon-Hee, additional, Kim, Ju Hwan, additional, Liao, Tzu-Chi, additional, Lau, Wallis C Y, additional, Man, Kenneth K C, additional, Qin, Xiwen, additional, Wood, Stephen, additional, Ilomäki, Jenni, additional, Bell, J Simon, additional, Lai, Edward Chia-Cheng, additional, Leung, Miriam T Y, additional, Chan, Adrienne Y L, additional, Chui, Celine S L, additional, Wong, Ian C K, additional, and Shin, Ju-Young, additional
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- 2023
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7. Epidemiology of Acute Myocarditis/Pericarditis in Hong Kong Adolescents Following Comirnaty Vaccination
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Chua, Gilbert T, primary, Kwan, Mike Yat Wah, additional, Chui, Celine S L, additional, Smith, Robert David, additional, Cheung, Edmund Chi Lok, additional, Ma, Tian, additional, Leung, Miriam T Y, additional, Tsao, Sabrina Siu Ling, additional, Kan, Elaine, additional, Ng, Wing Kei Carol, additional, Chan, Victor Chi Man, additional, Tai, Shuk Mui, additional, Yu, Tak Ching, additional, Lee, Kwok Piu, additional, Wong, Joshua Sung Chih, additional, Lin, Ying Kit, additional, Shek, Chi Chiu, additional, Leung, Agnes Sze Yin, additional, Chow, Chit Kwong, additional, Li, Ka Wah, additional, Ma, Johnny, additional, Fung, Wai Yuk, additional, Lee, Daniel, additional, Ng, Ming Yen, additional, Wong, Wilfred Hing Sang, additional, Tsang, Hing Wai, additional, Kwok, Janette, additional, Leung, Daniel, additional, Chung, Kin Lai, additional, Chow, Chun Bong, additional, Chan, Godfrey Chi Fung, additional, Leung, Wing Hang, additional, To, Kelvin Kai Wang, additional, Yuen, Kwok Yung, additional, Lau, Yu Lung, additional, Wong, Ian Chi Kei, additional, and Ip, Patrick, additional
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- 2021
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8. Epidemiology of Acute Myocarditis/Pericarditis in Hong Kong Adolescents Following Comirnaty Vaccination.
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Chua, Gilbert T, Kwan, Mike Yat Wah, Chui, Celine S L, Smith, Robert David, Cheung, Edmund Chi Lok, Ma, Tian, Leung, Miriam T Y, Tsao, Sabrina Siu Ling, Kan, Elaine, Ng, Wing Kei Carol, Chan, Victor Chi Man, Tai, Shuk Mui, Yu, Tak Ching, Lee, Kwok Piu, Wong, Joshua Sung Chih, Lin, Ying Kit, Shek, Chi Chiu, Leung, Agnes Sze Yin, Chow, Chit Kwong, and Li, Ka Wah
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PERICARDITIS ,IMMUNIZATION ,CONFIDENCE intervals ,CARDIOMYOPATHIES ,COVID-19 vaccines ,PHARMACOLOGY ,DISEASE incidence ,DESCRIPTIVE statistics ,LONGITUDINAL method ,ADOLESCENCE - Abstract
Background Age-specific incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination in Asia is lacking. This study aimed to study the clinical characteristics and incidence of acute myocarditis/pericarditis among Hong Kong adolescents following Comirnaty vaccination. Methods This is a population cohort study in Hong Kong that monitored adverse events following immunization through a pharmacovigilance system for coronavirus disease 2019 (COVID-19) vaccines. All adolescents aged between 12 and 17 years following Comirnaty vaccination were monitored under the COVID-19 vaccine adverse event response and evaluation program. The clinical characteristics and overall incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination were analyzed. Results Between 14 June 2021 and 4 September 2021, 33 Chinese adolescents who developed acute myocarditis/pericarditis following Comirnaty vaccination were identified. In total, 29 (87.88%) were male and 4 (12.12%) were female, with a median age of 15.25 years. And 27 (81.82%) and 6 (18.18%) cases developed acute myocarditis/pericarditis after receiving the second and first dose, respectively. All cases are mild and required only conservative management. The overall incidence of acute myocarditis/pericarditis was 18.52 (95% confidence interval [CI], 11.67–29.01) per 100 000 persons vaccinated. The incidence after the first and second doses were 3.37 (95% CI, 1.12–9.51) and 21.22 (95% CI, 13.78–32.28 per 100 000 persons vaccinated, respectively. Among male adolescents, the incidence after the first and second doses were 5.57 (95% CI, 2.38–12.53) and 37.32 (95% CI, 26.98–51.25) per 100 000 persons vaccinated. Conclusions There is a significant increase in the risk of acute myocarditis/pericarditis following Comirnaty vaccination among Chinese male adolescents, especially after the second dose. [ABSTRACT FROM AUTHOR]
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- 2022
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9. Linking cohort-based data with electronic health records: a proof-of-concept methodological study in Hong Kong
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Gao, Le, primary, Leung, Miriam T Y, additional, Li, Xue, additional, Chui, Celine S L, additional, Wong, Rosa S M, additional, Au Yeung, Shiu Lun, additional, Chan, Edward W W, additional, Chan, Adrienne Y L, additional, Chan, Esther W, additional, Wong, Wilfred H S, additional, Lee, Tatia M C, additional, Rao, Nirmala, additional, Wing, Yun Kwok, additional, Lum, Terry Y S, additional, Leung, Gabriel M, additional, Ip, Patrick, additional, and Wong, Ian C K, additional
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- 2021
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10. Maternal Thyroid Dysfunction During Pregnancy and the Risk of Adverse Outcomes in the Offspring: A Systematic Review and Meta-Analysis
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Ge, Grace Mengqin, primary, Leung, Miriam T Y, additional, Man, Kenneth K C, additional, Leung, Wing Cheong, additional, Ip, Patrick, additional, Li, Gloria H Y, additional, Wong, Ian C K, additional, Kung, Annie W C, additional, and Cheung, Ching-Lung, additional
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- 2020
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11. Lithium and the risk of fractures in patients with bipolar disorder: A population-based cohort study.
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Ng VWS, Leung MTY, Lau WCY, Chan EW, Hayes JF, Osborn DPJ, Cheung CL, Wong ICK, and Man KKC
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- Humans, Female, Male, Middle Aged, Adult, Anticonvulsants adverse effects, Anticonvulsants therapeutic use, Cohort Studies, Lithium Compounds adverse effects, Lithium Compounds therapeutic use, Aged, United Kingdom epidemiology, Lithium therapeutic use, Lithium adverse effects, Bipolar Disorder drug therapy, Bipolar Disorder epidemiology, Antipsychotic Agents adverse effects, Fractures, Bone epidemiology, Fractures, Bone chemically induced, Antimanic Agents adverse effects, Antimanic Agents therapeutic use
- Abstract
Lithium is considered to be the most effective mood stabilizer for bipolar disorder. Evolving evidence suggested lithium can also regulate bone metabolism which may reduce the risk of fractures. While there are concerns about fractures for antipsychotics and mood stabilizing antiepileptics, very little is known about the overall risk of fractures associated with specific treatments. This study aimed to compare the risk of fractures in patients with bipolar disorder prescribed lithium, antipsychotics or mood stabilizing antiepileptics (valproate, lamotrigine, carbamazepine). Among 40,697 patients with bipolar disorder from 1993 to 2019 identified from a primary care electronic health record database in the UK, 13,385 were new users of mood stabilizing agents (lithium:2339; non-lithium: 11,046). Lithium was associated with a lower risk of fractures compared with non-lithium treatments (HR 0.66, 95 % CI 0.44-0.98). The results were similar when comparing lithium with prolactin raising and sparing antipsychotics, and individual antiepileptics. Lithium use may lower fracture risk, a benefit that is particularly relevant for patients with serious mental illness who are more prone to falls due to their behaviors. Our findings could help inform better treatment decisions for bipolar disorder, and lithium's potential to prevent fractures should be considered for patients at high risk of fractures., Competing Interests: Declaration of competing interest Esther W. Chan has received grants from Research Grants Council (RGC, Hong Kong), Research Fund Secretariat of the Food and Health Bureau, National Natural Science Fund of China, Bayer, Bristol-Myers Squibb, Pfizer, Janssen, Novartis, Amgen, AstraZeneca, Takeda, the RGA Reinsurance Company, Narcotics Division of the Security Bureau of the Hong Kong Special Administrative Region, the National Health and Medical Research Council Australia; consulting fees from AstraZeneca, Pfizer and Novartis; and honorarium from the Hospital Authority Hong Kong, outside the submitted work. Joseph F. Hayes has received consultancy fees from Wellcome Trust and juli Health. Kenneth K.C. Man received the CW Maplethorpe Fellowship, grants from the National Institute for Health Research (United Kingdom), the European Union Horizon 2020 Framework, Innovation and Technology Commission of the Hong Kong Special Administration Region Government, and Hong Kong Research Grant Council and personal fees from IQVIA Holdings, Inc., unrelated to this work. Ian C.K.Wong received research grants from Amgen, Janssen, GSK, Novartis, Pfizer, Bayer and Bristol-Myers Squibb and Takeda, Institute for Health Research in England, European Commission, National Health and Medical Research Council in Australia, The European Union's Seventh Framework Programme for research, technological development, Research Grants Council Hong Kong and Health and Medical Research Fund Hong Kong; consulting fee from IQVIA and WHO; payment for expert testimony for Appeal Court in Hong Kong; serves on advisory committees for Member of Pharmacy and Poisons Board; Member of the Expert Committee on Clinical Events Assessment Following COVID-19 Immunization; Member of the Advisory Panel on COVID-19 Vaccines of the Hong Kong Government; is the non-executive director of Jacobson Medical in Hong Kong; is the Founder and Director of Therakind Limited (UK), Advance Data Analytics for Medical Science (ADAMS) Limited (HK), Asia Medicine Regulatory Affairs (AMERA) Services Limited and OCUS Innovation Limited (HK, Ireland and UK). Ching-Lung Cheung received research grants and the honorarium from Amgen, research grant support from HMRF, and the honorarium from Abbott. Wallis C.Y. Lau reports grant from Diabetes UK, AIR@InnoHK administered by Innovation and Technology Commission, outside the submitted work. Vanessa W.S. Ng, Miriam T.Y. Leung, and David P.J. Osborn declare no conflict of interest., (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
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- 2024
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12. Association between the mood stabilizing treatment of bipolar disorder and risk of suicide attempts: A self-controlled case series study.
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Ng VWS, Leung MTY, Chan EW, Lee EHM, Hayes JF, Osborn DPJ, Wing YK, Lau WCY, Man KKC, and Wong ICK
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- Risk Factors, Humans, Anticonvulsants, Lithium therapeutic use, Male, Female, Adult, Middle Aged, Treatment Outcome, Bipolar Disorder drug therapy, Suicide, Attempted, Antipsychotic Agents therapeutic use, Excipients therapeutic use
- Abstract
Bipolar disorder (BPD) is associated with high rates of suicide attempts but the anti-suicidal effect of mood stabilizing agents remains unclear. This study aimed to examine the association between mood stabilizing agents (lithium, valproate, lamotrigine, carbamazepine or antipsychotics) and risk of suicide attempts in patients with BPD using self-controlled case series study design. Among 14,087 patients with BPD who received mood stabilizing agents from 2001 to 2020 in Hong Kong, 1316 patients had at least one suicide attempts during the observation period. An increased risk of suicide attempts was observed 14 days before treatment initiation compared to non-exposed period. Following treatment initiation, an increased risk with smaller magnitude was found with the use of mood stabilizing agents. A lower risk was observed with lithium and antiepileptics while the risk remained attenuated with decreasing magnitude with antipsychotics. During 30-day post-treatment period, the risk was elevated. Therefore, this study suggests that use of mood stabilizing agents is not causally associated with an increased risk of suicide attempts. Indeed, there are potential protective effects of lithium and antiepileptics against suicide attempts. Assiduous monitoring of symptoms relapse and warning signs of suicide should be part of the management plan and discussed between clinicians, caregivers and patients., Competing Interests: Declaration of Competing Interest Esther W. Chan has received grants from Research Grants Council (RGC, Hong Kong), Research Fund Secretariat of the Food and Health Bureau, National Natural Science Fund of China, Bayer, Bristol-Myers Squibb, Pfizer, Janssen, Novartis, Amgen, AstraZeneca, Takeda, the RGA Reinsurance Company, Narcotics Division of the Security Bureau of the Hong Kong Special Administrative Region, the National Health and Medical Research Council Australia; consulting fees from AstraZeneca, Pfizer and Novartis; and honorarium from the Hospital Authority Hong Kong, outside the submitted work. Joseph F. Hayes has received consultancy fees from Wellcome Trust and juli Health.Yun Kwok Wing has received honorarium from Eisai Hong Kong and consultation fees from Eisai Co., Ltd, grants from Research Grants Council (RGC, Hong Kong). Wallis C.Y. Lau reports grant from AIR@InnoHK administered by Innovation and Technology Commission, outside the submitted work. Kenneth K.C. Man received the CW Maplethorpe Fellowship, grants from the National Institute for Health Research, United Kingdom; the European Union Horizon 2020 Framework; Hong Kong Research Grant Council and personal fees from IQVIA Holdings, Inc., unrelated to this work. Ian C.K. Wong has received grants from the Research Grants Council (RGC, Hong Kong), the National Institute for Health Research, United Kingdom, National Health and Medical Research Council in Australia, Innovative Medicines Initiative (IMI), Shire, Janssen-Cilag, Eli-Lily, Pfizer, Bayer, Bristol-Myers Squibb, Takeda, Amgen, AstraZeneca and the European Union FP7 program. He is a member of the National Institute for Health and Clinical Excellence (NICE) ADHD Guideline Group, the British Association for Psychopharmacology ADHD guideline group and an advisor to Shire. He also receives personal fee from IQVIA and Jacobson Pharmaceutical and speaker fees from Janssen and Medice in the previous 3 years. Vanessa W.S. Ng, Miriam T.Y. Leung, Edwin H.M. Lee, and David P.J. Osborn, declare no conflict of interest., (Copyright © 2023. Published by Elsevier B.V.)
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- 2023
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13. Risk of Adverse Events and Delirium after COVID-19 Vaccination in Patients Living with Dementia.
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Cheung ECL, Leung MTY, Chen K, Wan EYF, Li X, Lai FTT, Wong CKH, Qin XS, Chan EW, Lau KK, Luo H, Lin CC, Wong ICK, and Chui CSL
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- Humans, Aged, COVID-19 Vaccines adverse effects, BNT162 Vaccine, Cohort Studies, SARS-CoV-2, Vaccination adverse effects, COVID-19 epidemiology, COVID-19 prevention & control, Dementia epidemiology, Delirium epidemiology, Delirium etiology
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Objectives: The aim of this study was to compare incidences of adverse events of special interest (AESI) and delirium in 3 cohorts: after COVID-19 vaccination, prepandemic, and SARS-CoV-2 polymerase chain reaction (PCR) test positive., Design: This is a population-based cohort study using electronic medical records linked with vaccination records in Hong Kong., Setting and Participants: A total of 17,449 older people with dementia received at least 1 dose of CoronaVac (n = 14,719) or BNT162b2 (n = 2730) between February 23, 2021, and March 31, 2022. Moreover, 43,396 prepandemic and 3592 SARS-CoV-2 test positive patients were also included in this study., Methods: The incidences of AESI and delirium up to 28 days after vaccination in the vaccinated dementia cohort were compared with the prepandemic and SARS-CoV-2 test positive dementia cohorts by calculating incidence rate ratios (IRRs). Patients who received multiple doses were followed up separately for each dose, up to the third dose., Results: We did not detect an increased risk of delirium and most AESI following vaccination compared to the prepandemic period and those tested positive for SARS-CoV-2. No AESI group nor delirium incidence exceeded 10 per 1000 person-days in vaccinated individuals., Conclusions and Implications: The findings provide evidence for the safe use of COVID-19 vaccines in older patients with dementia. In the short run, benefit appears to outweigh the harm due to vaccine; however, longer follow-up should be continued to identify remote adverse events., (Copyright © 2023 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.)
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- 2023
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14. Gestational exposure to antidepressants and risk of seizure in offspring: A systematic review and meta-analysis.
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Leung MTY, Wong KH, Ho PWH, Ip P, Wei L, Wong ICK, and Man KKC
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- Antidepressive Agents adverse effects, Child, Female, Humans, Infant, Newborn, Pregnancy, Seizures chemically induced, Seizures drug therapy, Epilepsy drug therapy, Neurodevelopmental Disorders etiology, Pregnancy Complications chemically induced, Pregnancy Complications drug therapy, Pregnancy Complications epidemiology, Prenatal Exposure Delayed Effects chemically induced, Prenatal Exposure Delayed Effects epidemiology
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In spite of the preliminary evidence suggesting a link between gestational use of antidepressant and neurodevelopmental disorders in their offspring, the association between maternal use of antidepressants during pregnancy and the risk of neurologically-related adverse outcomes such as neonatal seizure is still unclear. This study summarises the available evidence on the association between gestational exposure to any antidepressants and the risk of seizure in neonates and children. We found that gestational antidepressant exposure is associated with a 2.3-fold higher incidence of seizure in offspring. Although a causal relationship cannot be confirmed in view of other potential confounders, our findings warrant future research on related clinical aspects, and possibly more careful monitoring of foetal neurodevelopment in pregnant women taking antidepressants during pregnancy. However, this does not suggest the abrupt withdrawal of antidepressants during pregnancy for all cases at risk of seizure in offspring as this must be balanced with the risk of negative consequences caused by untreated maternal depression, and decision-making should be individualised for each patient., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
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- 2021
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