204 results on '"Letting AS"'
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2. Uncovering the Relationship between Perceptions of Psychological Safety, Entrepreneurial Self-Efficacy, and Entrepreneurial Bricolage Behaviors.
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Cynthia Letting and Jessica Menold
- Published
- 2023
3. Concurrent Voltage and Frequency Regulation via Distributed Droop-Based Control Method in an Autonomous Microgrid.
- Author
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Shu Godwill Ndeh, Divine Khan Ngwashi, Lawrence K. Letting, Musong Louis Katche, and Tanyi Emmanuel
- Published
- 2023
- Full Text
- View/download PDF
4. Power sharing enhancement through a decentralized droop-based control strategy in an islanded microgrid
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Ndeh, Shu Godwill, Ngwashi, Divine Khan, Letting, Lawrence K., Iweh, Chu Donatus, and Tanyi, Emmanuel
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- 2024
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- View/download PDF
5. Power sharing enhancement through a decentralized droop-based control strategy in an islanded microgrid
- Author
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Shu Godwill Ndeh, Divine Khan Ngwashi, Lawrence K. Letting, Chu Donatus Iweh, and Emmanuel Tanyi
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Microgrid ,Droop control ,Active power ,Reactive power ,NARX ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
A decentralized intelligent droop-based control strategy is proposed in this paper for the enhancement of equal active and reactive power sharing in an islanded inverter-based microgrid. Droop control is mostly preferred because it does not need communication facilities for its implementation. However, the presence of different feeder impedances for the different distributed generators (DGs) in a microgrid make reactive power sharing inaccurate. Furthermore, as a result of considerable load changes and different droop characteristics for the DGs, the inverter's output voltage and frequency are altered and these in turn alter the reactive and active power sharing respectively. With these conditions, the generalized droop control (GDC) strategy fails to effectively share load reactive and active power among the DGs. In order to extenuate these challenges, this paper presents a nonlinear autoregressive exogenous neural network droop-based control (NARX-NN DBC) strategy which does not depend on the varying line impedances, droop gains for the different DGs and is less affected by fluctuating loads in the grid. A microgrid, made up of two DGs and a load is modelled in MATLAB/Simulink environment and validation of the proposed control strategy is done through many simulations. Within the simulation runtime, NARX-NN DBC yielded a maximum frequency percentage deviation of 0.46% from the nominal value of 50 Hz whereas GDC yielded 0.62%. Regarding the voltage, NARX-NN DBC gave maximum deviation of 0.026% meanwhile GDC gave 0.079% from the nominal value for 380 V. In addition, during 0.57–0.64 s with load active power demand of 4.6 kW, NARX-NN DBC registered 0.43% power sharing error whereas GDC registered 6.5%. On the other hand, during 0.57–0.64 s, with 5kVAr load power demand, NARX-NN DBC registered 0.2% whereas, GDC registered 2%. These obtained results clearly show that NARX-NN DBC strategy has a better performance compared to GDC strategy with respect to power sharing in an autonomous microgrid.
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- 2024
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6. Setting the research agenda: involving parents in research on children who are HIV‐free
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Laurette L. Bukasa, Angelina Namiba, Matilda Brown, Estelle Ndu'ngu, Mercy Nangwale, Gillian Letting, Patricia Chirwa, Claire Thorne, and Shema Tariq
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public engagement ,co‐production ,women ,children ,community ,HIV ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Introduction There is growing interest in health, developmental and survival outcomes of children who are born HIV‐free to women living with HIV (children born HIV‐free). To date, the research agenda has been largely determined by researchers, funders and policy makers, with limited involvement of parents, who are key stakeholders. Researchers at UCL Great Ormond Street Institute of Child Health in partnership with community‐based organisation 4M Network of Mentor Mothers conducted two workshops with parents in March 2022 to establish research priorities for children born HIV‐free, and key considerations for methodological approaches both to research and engagement with the affected communities. Discussion When exploring research on children born HIV‐free, we consider the following: what aspects of current research are aligned with women and parents’ priorities, what is missing and what approaches would be preferred. A holistic approach to research on children born HIV‐free should be prioritised, focussing on a breadth of outcomes and how they intersect. Secondary use of existing data sources should be maximised to facilitate this, with a view of monitoring the long‐term effects of fetal antiretroviral drug exposure alongside other key health and developmental outcomes. Involving and engaging with parents, and children where possible, must be at the heart of research design to maximise relevance and impact of findings for the affected communities. Potential barriers to engaging with individuals who were children born HIV‐free include parental disclosure and individuals not identifying as a child born HIV‐free to a mother living with HIV. Stigma‐free language must be incorporated into the vocabulary of researchers and other stakeholders, avoiding reference to exposure; we propose the term “children born HIV‐free.” Conclusions Mothers and parents living with HIV should be involved in research about their children born HIV‐free and are key in identifying research priorities so that findings may translate into an impact on their children's health and wellbeing. Meaningful involvement of women living with HIV through trusted community partners is an effective mechanism by which to elicit views on research about their children.
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- 2023
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- View/download PDF
7. Setting the research agenda: involving parents in research on children who are HIV‐free
- Author
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Bukasa, Laurette L., Namiba, Angelina, Brown, Matilda, Ndu'Ngu, Estelle, Nangwale, Mercy, Letting, Gillian, Chirwa, Patricia, Thorne, Claire, and Tariq, Shema
- Subjects
Maternal-fetal exchange -- Health aspects ,Clinical trials -- Management ,HIV infection -- Prevention ,Company business management ,Health - Abstract
: Introduction: There is growing interest in health, developmental and survival outcomes of children who are born HIV‐free to women living with HIV (children born HIV‐free). To date, the research agenda has been largely determined by researchers, funders and policy makers, with limited involvement of parents, who are key stakeholders. Researchers at UCL Great Ormond Street Institute of Child Health in partnership with community‐based organisation 4M Network of Mentor Mothers conducted two workshops with parents in March 2022 to establish research priorities for children born HIV‐free, and key considerations for methodological approaches both to research and engagement with the affected communities. Discussion: When exploring research on children born HIV‐free, we consider the following: what aspects of current research are aligned with women and parents’ priorities, what is missing and what approaches would be preferred. A holistic approach to research on children born HIV‐free should be prioritised, focussing on a breadth of outcomes and how they intersect. Secondary use of existing data sources should be maximised to facilitate this, with a view of monitoring the long‐term effects of fetal antiretroviral drug exposure alongside other key health and developmental outcomes. Involving and engaging with parents, and children where possible, must be at the heart of research design to maximise relevance and impact of findings for the affected communities. Potential barriers to engaging with individuals who were children born HIV‐free include parental disclosure and individuals not identifying as a child born HIV‐free to a mother living with HIV. Stigma‐free language must be incorporated into the vocabulary of researchers and other stakeholders, avoiding reference to exposure; we propose the term “children born HIV‐free.” Conclusions: Mothers and parents living with HIV should be involved in research about their children born HIV‐free and are key in identifying research priorities so that findings may translate into an impact on their children's health and wellbeing. Meaningful involvement of women living with HIV through trusted community partners is an effective mechanism by which to elicit views on research about their children., INTRODUCTION Successes in preventing vertical transmission (VT) have led to substantially fewer children being born with HIV [1]. In parallel, the number of children who are born HIV‐free to women [...]
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- 2023
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8. Make it or draw it? Investigating the communicative trade-offs between sketches and prototypes
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Sandeep Krishnakumar, Cynthia Letting, Erin Johnson, Nicolas F. Soria Zurita, and Jessica Menold
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design communication ,prototypes ,sketches ,cognitive load ,Drawing. Design. Illustration ,NC1-1940 ,Engineering design ,TA174 - Abstract
Design representations play a crucial role in facilitating communication between individuals in design. Sketches and physical prototypes are frequently used to communicate design concepts in early-stage design. However, we lack an understanding of the communicative benefits each representation provides and how these benefits relate to the effort and resources required to create each representation. A mixed-methods study was conducted with 44 participants to identify whether sketches and physical prototypes led to different levels of cognitive load perceived by a communicator and listener and the characteristics that shape their cognitive load during communication. Results showed that listeners perceived higher levels of mental and physical demands when understanding ideas as low-fidelity physical prototypes, as compared to sketches. No significant differences were found in the cognitive load levels of communicators between the two conditions. Qualitative analyses of post-task semi-structured interviews identified five themes relating to verbal explanations and visual representations that shape designers’ cognitive load when understanding and communicating ideas through design representations. Results indicate that designers should be aware of the specific objectives they seek to accomplish when selecting the design representation used to communicate. This work contributes to the knowledge base needed for designers to use design representations more effectively as tools for communication.
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- 2023
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9. Breeding potential of lablab [Lablab purpureus (L.) Sweet]: a review on characterization and bruchid studies towards improved production and utilization in Africa
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Letting, Fanuel K., Venkataramana, Pavithravani B., and Ndakidemi, Patrick A.
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- 2021
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10. What do women living with HIV think about research on children born HIV-free in the UK?
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Laurette Bukasa, Angelina Namiba, Shema Tariq, Matilda Brown, Estelle Ndungu, Mercy Nangwale, Gillian Letting, Patricia Chirwa, and Claire Thorne
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HIV research ,Women ,Mothers ,Linked data ,Public engagement ,Demography. Population. Vital events ,HB848-3697 - Abstract
Objective We are analysing linked public health surveillance data on pregnancies to women living with HIV in the UK and vital registration data on all their children born HIV-free, an under-researched group. We sought to engage women living with HIV to elicit their feedback on our work and set research priorities. Approach In partnership with 4M Net, a national peer-support network for mothers living with HIV, we co-designed and held two online workshops (one workshop a week over two weeks) in March 2022. We designed the workshops to be highly interactive, using a combination of online tools and created a safe space for open discussion. All participants received a preparatory booklet in advance, comprising questions, activities, and space for reflections during the workshops. We also prompted participants to discuss their research priorities with peers and/or family members if they felt comfortable with this. Results In total, 6 participants attended the two 2-hour long workshops. All participants were from Black ethnic backgrounds, aged 30 years or older and were mothers of children or young adults born HIV-free. Overall, participants were positive about the programme of research and identified pregnancy, birth, and long-term outcomes in children (especially regarding HIV medication in pregnancy) as being of key importance. They supported the use of linked mental health, hospital, general practice (GP), health visiting and education data to explore pregnancy, health and developmental outcomes among children born HIV-free. Linkage to GP data was identified as a priority by participants, and there was particular interest in addressing knowledge gaps on the mental health of children and young adults born HIV-free. Conclusion Women living with HIV are often involved in research around pregnancy, but rarely in research about their children. By working with trusted community partners, we can engage this often marginalised group of parents who understand the value of linked data research exploring the health and wellbeing of their children born HIV-free.
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- 2022
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11. Effect on Transient Stability and Analyses Resulting from a Cyber-Attack on Frequency Relay Device.
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Darius Muyizere, Lawrence K. Letting, and Bernard B. Munyazikwiye
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- 2023
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12. Farmers’ Participatory Plant Selection of Lablab (Lablab purpureus (L.) Sweet) in Tanzania
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Fanuel K. Letting, Pavithravani B. Venkataramana, and Patrick A. Ndakidemi
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lablab (Lablab purpureus) ,participatory breeding ,production practices ,production constraints ,trait preferences ,Plant culture ,SB1-1110 - Abstract
Farmer-participatory breeding approach is an important component in the crop improvement of lablab (Lablab purpureus (L.) Sweet). The study was carried out to obtain the knowledge, practices and preferences of lablab through 31 lablab growing-farmers from Arusha, Kondoa, Karatu, Same and Babati districts of Tanzania toward initiating a lablab breeding program. Semi-structured questionnaires were administered and focused group discussions were held to collect data on the socio-demographic factors, production practices, constraints and farmer’s preferred traits of lablab. Selection of preferred traits and accessions was also done by the farmers in the field. Results showed that the chief constraints of lablab production are pests and diseases, poor marketability, low seed quality, inadequate rainfall, expensive agrochemicals, low yield, and poor storage facilities. The major pests are pod borer (field) and bruchids (storage). Preferred traits for lablab improvement include the development of insect pests and disease-resistant varieties, early maturing, high yield, black colored seed for market, short cooking time, and dense foliage. Genotypes EK2, D360, HA4, and D96 with preferred traits were identified by farmers, which forms critical decisions in crop improvement. This study describes the current view of lablab production and generates the understanding of farmers’ perceptions and preferences vital for breeding priorities and programs to increase its production, utilization and consumption.
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- 2022
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13. If you build it, will they understand? Considerations for creating shared understanding through design artifacts
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Krishnakumar, Sandeep, primary, Letting, Cynthia, additional, Soria Zurita, Nicolás F., additional, and Menold, Jessica, additional
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- 2023
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14. Pre-Breeding Prospects of Lablab (Lablab purpureus (L.) Sweet) Accessions in Tanzania: Morphological Characterization and Genetic Diversity Analysis
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Fanuel Kiptoo Letting, Pavithravani Bangalore Venkataramana, and Patrick Alois Ndakidemi
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Lablab purpureus ,genetic diversity ,morpho-agronomic traits ,pivot table ,principal component analysis ,cluster analysis ,Agriculture - Abstract
Under-exploited crops such as Lablab purpureus are regarded a pathway towards alleviating the food and nutritional security in Sub-Saharan Africa. This study aimed at evaluating the morpho-agronomic diversity present in 277 lablab accessions based on 38 morpho-agronomic traits. The experiment was laid out in an Augmented design across two main cropping seasons in Tanzania. Qualitative data was analysed using pivot tables. The Generalized Linear Model (PROC GLM), Agglomerative Hierarchical Clustering (AHC) and Principal Component Analysis (PCA) were used to analyse variation of 14 quantitative traits. The findings revealed the presence of wide variability of the qualitative traits in the studied accessions. Significant differences were observed among accessions, between seasons, the interaction of blocks and season, and the season and accession effects in most of the traits. Most of the traits had high significant differences in relation to contrast among accessions, among checks and between accessions and checks. The first five principal components cumulatively accounted for 61.89% of the total variability among the accessions studied. Furthermore, cluster analysis grouped the accessions into four major clusters. This results suggest the 14 morpho-agronomic traits can successfully discriminate and show presence of wide diversity vital for selection and hybridization program of lablab species.
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- 2022
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15. An interface for coupling optimization algorithms with EPANET in discrete event simulation platforms.
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Lawrence K. Letting, Yskandar Hamam, and Adnan M. Abu-Mahfouz
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- 2017
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16. Context-Dependent Regulation of GATA-1 by Friend of GATA-1
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Letting, Danielle L., Chen, Ying-Yu, Rakowski, Carrie, Reedy, Sarah, and Blobel, Gerd A.
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- 2004
17. Concurrent Voltage and Frequency Regulation via Distributed Droop-Based Control Method in an Autonomous Microgrid
- Author
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Godwill Ndeh, Shu, primary, Ngwashi, Divine Khan, additional, Letting, Lawrence K., additional, Louis Katche, Musong, additional, and Emmanuel, Tanyi, additional
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- 2023
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18. A Droop-based Control Scheme for the Regulation of Voltage and Frequency in a Standalone Microgrid
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Ndeh, Shu Godwill, primary, Ngwashi, Divine Khan, additional, Letting, Lawrence K., additional, Nsanyuy, Wirnkar Basil, additional, and Emmanuel, Tanyi, additional
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- 2023
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19. Dealing With Loss: How Do Designers’ Resilience and Perceptions of Scarcity Affect Perceptions of Design Performance?
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Sibley, Grace, additional, Letting, Cynthia, additional, and Menold, Jessica, additional
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- 2023
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20. From Obstacles to Opportunities: How Perceptions of Psychological Safety Affect Founders’ Abilities to Identify Resources
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Letting, Cynthia, additional, Calpin, Nicole, additional, Soria Zurita, Nicolás F., additional, and Menold, Jessica, additional
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- 2023
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21. Empathic Ability Vs. User Satisfaction: Evaluating the Role of Preference Accuracy in Engineering Design
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Johnson, Erin, additional, Letting, Cynthia, additional, Soria Zurita, Nicolás F., additional, and Menold, Jessica, additional
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- 2023
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22. If You Build It, Will They Understand? Considerations for Creating Shared Understanding Through Design Artifacts.
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Krishkakumar, Sandeep, Letting, Cynthia, Zurita, Nicolas F. Soria, and Menold, Jessica
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- *
CONCEPTUAL design , *DESIGN , *DYADS - Abstract
Design representations play a pivotal role in the design process. In particular, design representations enable the formation of a shared understanding between team members, enhancing team performance. This paper explores the relationship between design representation modality (low-fidelity prototypes and sketches) and shared understanding among designers during communicative acts between design dyads. A mixed-methods study with 44 participants was conducted to investigate if representation modality affects shared understanding and identifies the factors that shape shared understanding during communication. Quantitative results suggest that low-fidelity prototypes and sketches did not significantly differ in terms of the shared understanding they facilitated within dyads. Qualitative analysis identified four factors at the representation- and actor-level that influence how shared understanding is built between individuals during design communication. This research extends our understanding of the utility of design representations given the needs of communicative contexts; specifically, this work demonstrates that designers must understand the perspectives of listeners during communication to create representations that accurately represent the information that a listener seeks to gain. [ABSTRACT FROM AUTHOR]
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- 2024
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23. Reliability Assessment of Distribution System Grid-Connected Multi-Inverter for Solar Photo-Voltaic Systems: A Case Study.
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Muyizere, Darius, Nshimiyimana, Arcade, Mugerwa, Theophile, Letting, Lawrence K., and Munyazikwiye, Bernard B.
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RENEWABLE energy sources ,SOLAR system ,DISTRIBUTED power generation ,ELECTRON tube grids ,SOLAR technology ,ELECTRIC transients ,RELIABILITY in engineering - Abstract
The contemporary electrical grid aims to deliver safe and reliable energy to consumers. As technology advances and distributed generation (DG) becomes more prevalent, the distribution system grows increasingly complex and decentralized. The swift integration of renewable energy sources, driven by concerns about global warming and carbon emissions, adds to this complexity. Given the direct link between the distribution system and consumer needs, reliability is paramount. However, the current distribution system faces operational issues, necessitating a dependable, resilient power system devoid of interruptions and glitches. Distributed generation (DG), along with its grid integration, holds promise in significantly enhancing the reliability of the existing distribution system. This research studied a case study of distribution system reliability evaluation using solar PV in the system. Various instances were addressed, and we found that after implementing DG, system dependability increased. For the case study and analysis, data were taken from a solar photo-voltaic energy source linked to the Kigali national grid in the Rwanda bus system. The Electrical Transient Analyzer Program (ETAP 19) software is utilized for modeling and reliability analysis. [ABSTRACT FROM AUTHOR]
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- 2024
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24. Voltage Profile Analysis on a Grid with Power Injection from a Wind Farm
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Noah Serem, Josiah Munda, and Lawrence Letting
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wind energy ,power quality ,voltage profile ,grid ,Technology - Abstract
Wind power penetration into the grid is increasing throughout the world due to centralized power generation constraints such as shortage of fossil fuel, need to reduce gas emissions, long transmission losses and need for more supply of electrical power. Connection of wind power into the grid results in power quality issues such as voltage profile changes and harmonics. This necessitates coming up with correction measures in order to meet power quality standards. This paper deals with the analysis of the effects of injecting wind power to the grid on voltage profile. Branch participation factors are used to analyze the sections of the grid where effects on voltage profile are highest due to wind power penetration. Reactive power-voltage sensitivity analysis is used to determine the buses that are more sensitive to the changes brought by the wind power injection. Two cases were considered for the injection of the wind power: IEEE 14 test bus system and IEEE 39 test bus system.
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- 2021
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25. Evaluating patient experiences in decentralised acute care using the Picker Patient Experience Questionnaire; methodological and clinical findings
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Ann-Chatrin Linqvist Leonardsen, Vigdis Abrahamsen Grøndahl, Waleed Ghanima, Espen Storeheier, Anders Schönbeck, Thor-Asbjørn Løken, Nina Carine Mikkelsen Bakken, Guro Steine Letting, Réné Holst, and Lars-Petter Jelsness-Jørgensen
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Decentralised ,Acute healthcare ,Patient experiences ,Questionnaire ,Self-reported health ,Comorbidity ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Decentralised acute care services have, through the establishment of municipality acute wards (MAWs), been launched in Norway. The aim is to provide treatment for patients who otherwise would need hospitalisation. Currently there is a lack of studies investigating patient experiences in such services. The aims of this study were therefore to a) translate and validate the Picker Patient Experience Questionnaire (PPE-15) in Norwegian, and b) assess patient experiences in decentralised acute care, and potential factors associated with these experiences. Methods Patients were recruited from five municipal acute wards in southeastern Norway during the period from June 2014 to June 2015. Data on socio-demographics, length of stay and comorbidity (Charlson comorbidity index (CCI)) were collected. Patients completed the Picker Patient Experience Questionnaire (PPE-15) and the EuroQOL 5-dimension, 3-level version. Convergent validity of the PPE-15 was assessed by correlation of items in PPE-15 and the Nordic Patient Experience Questionnaire (NORPEQ). A retest of the PPE-15 was performed in a subgroup of patients approximately 3 weeks after baseline assessment. Test-retest agreement was assessed with Cohens’ unweighted Kappa. Results A total of 479 patients responded, median age 78.0 years and 41.8% men. A total of 68 patients participated in the retest. Testing of convergent validity revealed an overall weak to moderate correlation. Kappa statistics showed from fair to good test-retest agreement. Most problems were related to continuity and transition, while fewest problems were related to respect for patient preferences. A higher Charlson comorbidity score was the only variable that was negatively associated with patient experience. Conclusion Patients reported problems in several items of the PPE-15 after discharge from decentralised acute wards. The findings from the current study may be helpful for planning ways to improve quality of care, e.g., by providing feedback to healthcare personnel or by using patient experience as a quality indicator.
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- 2017
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26. Gallstone ileus
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Shanmugarajah, Inthujan, primary, Letting, Tord S., primary, and Rustad, Hege, primary
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- 2023
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27. Gallstone ileus
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Hege Rustad, Tord S. Letting, and Inthujan Shanmugarajah
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General Medicine - Published
- 2023
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28. Voltage Profile and Sensitivity Analysis for a Grid Connected Solar, Wind and Small Hydro Hybrid System
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Noah Serem, Lawrence K. Letting, and Josiah Munda
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voltage profile ,V-Q sensitivity ,solar PV ,wind power ,micro hydro ,D-STATCOM ,Technology - Abstract
Due to increase in integration of renewable energy into the grid and power quality issues arising from it, there is need for analysis and power improvement of such networks. This paper presents voltage profile, Q-V sensitivity analysis and Q-V curves analysis for a grid that is highly penetrated by renewable energy sources; solar PV, wind power and small hydro systems. Analysis is done on IEEE 39 bus test system with Wind power injection alone, PV power injection alone, with PV and wind power injection and with PV, wind and micro hydro power injection to the grid. The analysis is used to determine the buses where voltage stability improvement is needed. From the results, it was concluded that injection of the modeled wind power alone helped in stabilizing the voltage levels as determined from voltage profiles and reactive power margins. Replacing some of the conventional sources with PV power led to reduction of voltages for weak buses below the required standards. Injection of power from more than one renewable energy source helped in slightly improving the voltage levels. Distribution Static compensators (D-STATCOMs) were used to improve the voltage levels of the buses that were below the required standards.
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- 2021
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29. Enterprise Resource Planning Capability and Performance of Telecommunications Firms in Nairobi City County, Kenya
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Maurine Jepchirchir Letting and Dr. Josphat Kyalo
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Many IT enterprises in Kenya face the challenge to improve data and voice services' competitiveness, quantity, quality and dependability. Strategic IT is seen as a critical aspect to solve these difficulties. The improvement of firm competitiveness does not always ensure that company performance is improved. The study's specific objectives were as follows; to determine the effect of system integration, system security, management support and data storage on performance of telecommunications firms in Nairobi City County. The study was guided by game theory, resource-based theory, system theory and Unified Theory of Acceptance and Use of Technology. The target population was 250 staffs of telecommunications firms in Nairobi City County, Kenya from different departments. The study employed a descriptive research methodology, with a sample size of 153 selected participants using a simple random selection procedure. Based on the regression coefficients results above, department integration has a significant effect (β=0.158; p
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- 2022
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30. INVESTIGATING THE EFFECT OF SKETCH QUALITY ON THE SHARED UNDERSTANDING OF DESIGN DYADS.
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Letting, Cynthia, Krishnakumar, Sandeep, Johnson, Erin, Soria Zurita, Nicolas, and Menold, Jessica
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DYADS ,DESIGN services ,DRAWING ,PRODUCT design ,COMPREHENSION - Abstract
While a significant amount of research has documented the importance of design artefacts in design communication, relatively little work has investigated the effect of design artefact quality on the development of a shared understanding between designers. In the current work we focus specifically on sketch quality and the effect of sketch quality on the shared understanding of design dyads. A controlled study with 22 design dyads (44 designers) was conducted to understand the relationship between sketch quality and shared understanding. Results suggest that design artefact quality, measured by sketch understandability, does not predict the shared understanding of a design concept. Our findings hold implications for the fundamental ways in which we evaluate sketch quality and the importance of artefact fidelity for communicative acts. [ABSTRACT FROM AUTHOR]
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- 2023
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31. EXPLORING THE RELATIONSHIP BETWEEN GENDER IDENTITY AND THE DEVELOPMENT OF A SHARED UNDERSTANDING BETWEEN DESIGNERS.
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Johnson, Erin, Krishnakumar, Sandeep, Letting, Cynthia, Soria-Zurita, Nicolas, and Menold, Jessica
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GENDER identity ,PSYCHOLOGICAL safety ,TASK performance ,PRODUCT design - Abstract
Prior work has demonstrated that gender identity affects team psychological safety, which is critical to the development of a shared understanding of the task. Further, we know that a shared understanding can increase team cohesion and team performance. Little work has investigated how gender differences affect communicative acts within the context of design, and more specifically how gender differences may affect the development of a shared understanding of the design concept between designers. As a first step towards filling this gap, the current work presents findings from a controlled study conducted at The Pennsylvania State University with 22 design dyads (44 designers). The findings from this study indicate that gender identity within design dyads does not affect participants' shared understanding of a design concept. [ABSTRACT FROM AUTHOR]
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- 2023
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32. Optimal Placement and Sizing of Distributed Generation (DG) Units in Electrical Power Distribution Networks
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Moses, Irekefe A., primary, Kiprono, Letting L., additional, and Talai, Stephen M., additional
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- 2023
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33. Uncovering the Relationship between Perceptions of Psychological Safety, Entrepreneurial Self-Efficacy, and Entrepreneurial Bricolage Behaviors
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Letting, Cynthia, primary and Menold, Jessica, additional
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- 2023
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34. Norske gründeres erfaringer og lærdommer rundt å skape sitt første team
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Chadaré, Thomasine Jean, Larssen, Marie Letting, Bø, Veslemøy Bjelland, and Matthew Patrick James Lynch
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Entreprenøriell teamformasjon har fått mye oppmerksomhet i nyere tid. Likevel har flere forskere identifisert en mangel i teorien som omgir dette feltet. Gjennom kvalitativ forskning utført i det norske oppstartsmiljøet har vi forsøkt å avdekke aspekter ved teamformasjonsprosessen i praksis, med fokus på å identifisere muligheter og utfordringer knyttet til å bygge et team. I tråd med eksisterende teori identifiserer vi kjernekompetanse, riktig mentalitet og mellommenneskelig tiltrekning som tre viktige prinsipper for teamformasjon. Vi finner imidlertid at gründerne opplever det som utfordrende å tiltrekke seg teammedlemmer som besitter en kombinasjon av disse tre prinsippene, gitt oppstartsbedriftenes risikofylte natur. Vår forskning bidrar med en nyansering av entreprenøriell teamformasjon gjennom å belyse hvordan gründerne kan gå frem for å tiltrekke seg arbeidstakere fra millenniumsgenerasjonen, samt hvordan de kan tilrettelegge arbeidsforholdet for å beholde dem.
- Published
- 2023
35. Strategic Marketing and Organizational Performance: A Survey of Pharmaceutical Companies in Nairobi Metropolitan Kenya
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Nicholas Letting and Kenneth Kariuki Wangari
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Business ,Marketing ,Metropolitan area ,Organizational performance ,Strategic marketing - Published
- 2021
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36. A Fuzzy-PI Controller for Wind Turbine Driven DFIG Optimized using Genetic Algorithms.
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Lawrence K. Letting, Josiah L. Munda, and Yskandar Hamam
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- 2011
37. Optimization of Fuzzy Logic Controller Design for Maximum Power Point Tracking in Photovoltaic Systems.
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Lawrence K. Letting, Josiah L. Munda, and Yskandar Hamam
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- 2011
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38. Optimization of Fuzzy Logic Controller Design for Maximum Power Point Tracking in Photovoltaic Systems
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Letting, Lawrence K., Munda, Josiah L., Hamam, Yskandar, Kacprzyk, Janusz, editor, Gopalakrishnan, Kasthurirangan, editor, Khaitan, Siddhartha Kumar, editor, and Kalogirou, Soteris, editor
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- 2011
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39. Optimisation and rule firing analysis in fuzzy logic based maximum power point tracking.
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Lawrence K. Letting, Josiah L. Munda, and Yskandar Hamam
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- 2014
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40. Decreasing the Negative Impact of Time Delays on Electricity Due to Performance Improvement in the Rwanda National Grid
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Darius Muyizere, Lawrence K. Letting, and Bernard B. Munyazikwiye
- Subjects
Computer Networks and Communications ,Hardware and Architecture ,Control and Systems Engineering ,Signal Processing ,Electrical and Electronic Engineering ,communication and control ,Rwandan National Grid (RNG) ,fuzzy logic controller (FLC) ,power quality ,modified predictor method (MPM) - Abstract
One of the most common power problems today is communication and control delays. This can adversely affect decision interaction in grid security management. This paper focuses on communication signal delays and how to identify and address communication system failure issues in the context of grid monitoring and control, with emphasis on communication signal delay. An application to solve this problem uses a thyristor switch capacitor (TSC) and a thyristor-controlled reactor (TCR) to improve the power quality of the Rwandan National Grid (RNG) with synchronous and PV generators. It is to counteract the negative effects of time delays. To this end, the TSC and TCR architectures use two methods: the fuzzy logic controller (FLC) method and the modified predictor method (MPM). The experiment was performed using the Simulink MATLAB tool. The power quality of the system was assessed using two indicators: the voltage index and total harmonic distortion. The FLC-based performance was shown to outperform the MPM for temporary or permanent failures if the correct outcome was found. As a result, we are still unsure if TSC and TCR can continue to provide favorable results in the event of a network cyber-attack.
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- 2022
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41. Decreasing the Negative Impact of Time Delays on Electricity Due to Performance Improvement in the Rwanda National Grid
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Muyizere, Darius, primary, Letting, Lawrence K., additional, and Munyazikwiye, Bernard B., additional
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- 2022
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42. Pre-Breeding Prospects of Lablab (Lablab purpureus (L.) Sweet) Accessions in Tanzania: Morphological Characterization and Genetic Diversity Analysis
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Letting, Fanuel Kiptoo, primary, Venkataramana, Pavithravani Bangalore, additional, and Ndakidemi, Patrick Alois, additional
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- 2022
- Full Text
- View/download PDF
43. What do women living with HIV think about research on children born HIV-free in the UK?
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Bukasa, Laurette, primary, Namiba, Angelina, additional, Tariq, Shema, additional, Brown, Matilda, additional, Ndungu, Estelle, additional, Nangwale, Mercy, additional, Letting, Gillian, additional, Chirwa, Patricia, additional, and Thorne, Claire, additional
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- 2022
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44. THE DIGITAL ARTISTIC CYCLE IN PERFORMANCE ART EDUCATION
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Thanks to the University of Lapland, Nordic Culture Point and Lithuanian Council for Culture. Also, thanks to Vaida Tamoševičiūtė, Ieva Bartuškaitė and Lilija Gotautaitė for letting the researcher work with the described case., Griniuk, Marija, Thanks to the University of Lapland, Nordic Culture Point and Lithuanian Council for Culture. Also, thanks to Vaida Tamoševičiūtė, Ieva Bartuškaitė and Lilija Gotautaitė for letting the researcher work with the described case., and Griniuk, Marija
- Abstract
This research explores student performance art events in the current digital era. Public performance presentations by art students after the performance art course are intended to complete an artistic cycle. The artistic cycle in the digital era is divided into studio-based practice (when performance is planned, often in students’ home studios) and presentation in the digital space. For audience members, the experience of the performance artwork is significantly different in live and digital spaces since there is no possibility of touching the performer or items in the digital space. As a result, audience feedback for students differs greatly depending on whether the performance works are experienced live or virtually. Therefore, the present study suggests a new term of digital artistic cycle, which was developed after analysing a performance art course at Vilnius Academy of Arts, Kaunas Faculty in 2021. The data collected are the author’s notes from her observations and interviews with the facilitator of the performance art course. The data are analysed using keywords and categories. The results generated recommendations for performance art course facilitators regarding what tools should be used to complete an digital artistic cycle at universities and art academies.
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- 2022
45. Optimization of a fuzzy logic controller for PV grid inverter control using S-function based PSO
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Letting, L.K., Munda, J.L., and Hamam, Y.
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- 2012
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46. Farmers’ Participatory Plant Selection of Lablab (Lablab purpureus (L.) Sweet) in Tanzania
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Letting, Fanuel K., primary, Venkataramana, Pavithravani B., additional, and Ndakidemi, Patrick A., additional
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- 2022
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47. Enterprise Resource Planning Capability and Performance of Telecommunications Firms in Nairobi City County, Kenya
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Letting, Maurine Jepchirchir, primary and Kyalo, Dr. Josphat, additional
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- 2022
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48. Maternal beta‐blocker dose and risk of small‐for gestational‐age in women with heart disease
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Sørbye, Ingvil Krarup, primary, Haualand, Randi, additional, Wiull, Henriette, additional, Letting, Anne‐Sofie, additional, Langesæter, Eldrid, additional, and Estensen, Mette‐Elise, additional
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- 2022
- Full Text
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49. Prevalence and Clinical Outcomes of Poor Immune Response Despite Virologically Suppressive Antiretroviral Therapy Among Children and Adolescents With Human Immunodeficiency Virus in Europe and Thailand: Cohort Study
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Chappell, E., Riordan, A., Jourdain, G., Soriano-Arandes, A., Ene, L., Scherpbier, H., Warszawski, J., Collins, I., Smit, C., Marques, L., Klein, N., Guillén, S., Judd, A., Thorne, C., Goodall, R., Königs, C., Spoulou, V., Prata, F., Goetghebuer, T., Chiappini, E., Galli, L., Naver, L., Giaquinto, C., Gibb, D., Marczynska, M., Okhonskaia, L., Klimkait, T., Lallemant, M., Ngo-Giang-Huong, N., Kiseleva, G., Malyuta, R., Volokha, A., Hainaut, M., Delforge, M., Le Chenadec, J., Ramos, E., Dialla, O., Wack, T., Laurent, C., Ait Si Selmi, L., Leymarie, I., Ait Benali, F., Brossard, M., Boufassa, L., Floch-Tudal, C., Firtion, G., Hau, I., Chace, A., Bolot, P., Blanche, S., Levine, M., Bicëtre, L., Fourcade, C., Heller-Roussin, B., Runel-Belliard, C., Tricoire, J., Chirouze, C., Reliquet, V., Brouard, J., Kebaili, K., Fialaire, P., Lalande, M., Schultze-Strasser, S., Baumann, U., Niehues, T., Neubert, J., Kobbe, R., Berlin, C., Feiterna-Sperling, C., Buchholz, B., Notheis, G., de Martino, M., Angelo Tovo, P., Patrizia, O., Larovere, D., Ruggeri, M., Faldella, G., Baldi, F., Badolato, R., Montagnani, C., Venturini, E., Lisi, C., Di Biagio, A., Taramasso, L., Giacomet, V., Erba, P., Esposito, S., Lipreri, R., Salvini, F., Tagliabue, C., Cellini, M., Bruzzese, E., Lo Vecchio, A., Rampon, O., Donà, D., Romano, A., Dodi, I., Maccabruni, A., Consolini, R., Bernardi, S., Tchidjou Kuekou, H., Genovese, O., Olmeo, P., Cristiano, L., Mazza, A., Gabiano, C., Garazzino, S., Pellegatta, A., Pajkrt, D., Weijsenfeld, A., de Boer CG, Jurriaans, S., Back, N., Zaaijer, H., Berkhout, B., Cornelissen, M., Schinkel, C., Wolthers, K., Fraaij, P., van Rossum AMC, van der Knaap LC, Visser, E., Koopmans, M., van Kampen JJA, Pas, S., Henriet, S., van de Flier, M., van Aerde, K., Strik-Albers, R., Rahamat-Langendoen, J., Stelma, F., Schölvinck, E., de Groot-de Jonge, H., Niesters, H., van Leer-Buter CC, Knoester, M., Bont, L., Geelen, S., Wolfs, T., Nauta, N., Ang, C., van Houdt, R., Pettersson, A., Vandenbroucke-Grauls, C., Reiss, P., Bezemer, D., van Sighem AI, Wit, F., Boender, T., Zaheri, S., Hillebregt, M., de Jong, A., Bergsma, D., Grivell, S., Jansen, A., Raethke, M., Meijering, R., de Groot, L., van den Akker, M., Bakker, Y., Claessen, E., El Berkaoui, A., Koops, J., Kruijne, E., Lodewijk, C., Munjishvili, L., Peeck, B., Ree, C., Regtop, R., Ruijs, Y., Rutkens, T., Schoorl, M., Timmerman, A., Tuijn, E., Veenenberg, L., van der Vliet, S., Wisse, A., Woudstra, T., Tuk, B., Popielska, J., Pokorska-Śpiewak, M., Ołdakowska, A., Zawadka, K., Coupland, U., DorobaLaura Marques, M., Teixeira, C., Fernandes, A., Voronin, E., Miloenko, M., Labutina, S., Tomás Ramos, J., Prieto, L., Luisa Navarro, M., Saavedra, J., Santos, M., Angeles Muñoz, M., Ruiz, B., Mc Phee CF, de Ory SJ, Alvarez, S., Ángel Roa, M., Beceiro, J., Martínez, J., Badillo, K., Apilanez, M., Pocheville, I., Garrote, E., Colino, E., Gómez Sirvent, J., Garzón, M., Román, V., Montesdeoca, A., Mateo, M., José Muñoz, M., Angulo, R., Neth, O., Falcón, L., Terol, P., Luis Santos, J., Moreno, D., Lendínez, F., Grande, A., José Romero, F., Lillo, M., Losada, B., Herranz, M., Bustillo, M., Guerrero, C., Collado, P., Antonio Couceiro, J., Pérez, A., Isabel Piqueras, A., Bretón, R., Segarra, I., Gavilán, C., Jareño, E., Montesinos, E., Dapena, M., Álvarez, C., Gloria Andrés, A., Marugán, V., Ochoa, C., Alfayate, S., Isabel Menasalvas, A., de Miguel, E., Aebi-Popp, K., Asner, S., Aubert, V., Battegay, M., Baumann, M., Bernasconi, E., Böni, J., Brazzola, P., Bucher, H., Calmy, A., Cavassini, M., Ciuffi, A., Duppenthaler, A., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Francini, K., Furrer, H., Fux, C., Grawe, C., Günthard, H., Haerry, D., Hasse, B., Hirsch, H., Hoffmann, M., Hösli, I., Kahlert, C., Kaiser, L., Keiser, O., Kovari, H., Kouyos, R., Ledergerber, B., Martinetti, G., de Tejada BM, Metzner, K., Müller, N., Nicca, D., Paioni, P., Pantaleo, G., Polli, C., Posfay-Barbe, K., Rauch, A., Rudin, C., Schmid, P., Scherrer, A., Speck, R., Tarr, P., Thanh Lecompte, M., Trkola, A., Vernazza, P., Wagner, N., Wandeler, G., Weber, R., Wyler, C., Yerly, S., Techakunakorn, P., Hansudewechakul, R., Kham, C., Wanchaitanawong, V., Theansavettrakul, S., Sai, M., Nanta, S., Ngampiyaskul, C., Phanomcheong, S., Hongsiriwon, S., Karnchanamayul, W., Kwanchaipanich, R., Kanjanavanit, S., Kamonpakorn, N., Nantarukchaikul, M., Layangool, P., Mekmullica, J., Lucksanapisitkul, P., Watanayothin, S., Lertpienthum, N., Warachit, B., Hanpinitsak, S., Potchalongsin, S., Thanasiri, P., Krikajornkitti, S., Attavinijtrakarn, P., Srirojana, S., Bunjongpak, S., Puangsombat, A., Na-Rajsima, S., Ananpatharachai, P., Akarathum, N., Phuket, V., Lawtongkum, W., Kheunjan, P., Suriyaboon, T., Saipanya, A., Than-In-At, K., Jaisieng, N., Suaysod, R., Chailoet, S., Naratee, N., Kawilapat, S., Kaleeva, T., Baryshnikova, Y., Soloha, S., Bashkatova, N., Raus, I., Glutshenko, O., Ruban, Z., Prymak, N., Bailey, H., Bamford, A., Butler, K., Doerholt, K., Doherty, C., Foster, C., Francis, K., Harrison, I., Kenny, J., Letting, G., Mcmaster, P., Murau, F., Nsangi, E., Peters, H., Prime, K., Shackley, F., Shingadia, D., Storey, S., Tudor-Williams, G., Turkova, A., Welch, S., Jeannie Collins, I., Cook, C., Crichton, S., Dobson, D., Fairbrother, K., M Gibb D, Harper, L., Le Prevost, M., Van Looy, N., Walsh, A., Thrasyvoulou, L., Bernatoniene, J., Manyika, F., Sharpe, G., Subramaniam, B., Sloper, K., Fidler, K., Hague, R., Price, V., Clapson, M., Flynn, J., Cardoso, A., Abou-Rayyah, M., Gurtin, D., Yeadon, S., Segal, S., Ball, C., Hawkins, S., Dowie, M., Bandi, S., Percival, E., Eisenhut, M., Duncan, K., Clough, S., Anguvaa, L., Conway, S., Flood, T., Pickering, A., Murphy, C., Daniels, J., Lees, Y., Thompson, F., Williams, B., Pope, S., Cliffe, L., Smyth, A., Southall, S., Freeman, A., Freeman, H., Christie, S., Gordon, A., Rogahn, D., Clarke, L., Jones, L., Offerman, B., Greenberg, M., Benson, C., Ibberson, L., Faust, S., Hancock, J., Sharland, M., Lyall, H., Monrose, C., Seery, P., Menson, E., Callaghan, A., Bridgwood, A., Evans, J., Blake, E., Yannoulias, A., Critchton, S., Duff, C., Gomezpena, D., Lundin, R., Mangiarini, L., Nardone, A., Posfay Barbe, Klara, Universidad de Alcalá - University of Alcalá (UAH), Department of Sciences for Woman and Child's Health, Università degli Studi di Firenze = University of Florence (UniFI), Épidémiologie clinique, santé mère-enfant et VIH en Asie du Sud-Est (IRD_PHPT), Harvard University-Chiang Mai University (CMU), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier de Saint-Denis [Ile-de-France], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), service de maladies infectieuses CHU J Minjoz Besancon, Service des maladies infectieuses et tropicales [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Service de Pédiatrie Médicale [Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Service d'hématologie : Immuno-Hématologie pédiatrique et transplantation de moelle osseuse, Hôpital Debrousse, Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Universitätsklinikum Frankfurt, Infectious Diseases, San Martino Hospital, Università degli studi di Genova = University of Genoa (UniGe), Department of Maternal and Pediatric Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Maternal-Infantile Department, Unit of Paediatrics and Oncohematology, University Hospital of Parma, Department of Infectious Diseases, IRCCS S. Matteo, Department of Paediatrics, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Dipartimento di Ingegneria [Benevento], Università degli Studi del Sannio, University of Twente, Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratory for Infectious Diseases and Perinatal Screening, Center for Infectious Disease Control, National Institute for Public Health and the Environment [Bilthoven] (RIVM), Architecture et réactivité de l'ARN (ARN), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Synthèse, Structure et Propriétés de Matériaux Fonctionnels (STEP), SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé (SYMMES), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Département Interfaces pour l'énergie, la Santé et l'Environnement (DIESE), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Stichting HIV Monitoring, Universidade Federal do Ceará = Federal University of Ceará (UFC), Departamento de Química Orgánica, Universidade de Vigo, Polytechnical University of Valencia, Fac Biol, Dept Genet, Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Service des maladies infectieuses, Hôpitaux Universitaires de Genève (HUG), University of Basel (Unibas), Dysfonctions métaboliques et diabètes: Mécanismes et approches thérapeutiques, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM), University Heart Centre Freiburg - Bad Krozingen, Prapokklao Hospital [Chanthaburi, Thailand], Nakornping Hospital [Chiang Mai, Thailand], Samutsakhon Hospital [Samutsakhon, Thailand], Kalasin Hospital [Kalasin, Thailand], Sanpatong Hospital [Chiang Mai, Thailand], Chiang Mai University (CMU), Microbiology Department, St. Jame's Hospital, University of Edinburgh, Infectious Diseases and Microbiology Unit, Great Ormond Street Hospital for Children [London] (GOSH)-Institute of Child Health, European Synchrotron Radiation Facility (ESRF), Centre for Ecology and Hydrology [Bangor] (CEH), Natural Environment Research Council (NERC), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), University of London [London], London South Bank University (LSBU), Dipartimento di Pediatria, Azienda Ospedaliera di Padova, Université Grenoble Alpes - UFR Pharmacie (UGA UFRP), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), The European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) Study Group in EuroCoord, Florence University, Harvard University [Cambridge]-Chiang Mai University (CMU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), University of Genoa (UNIGE), Catholic University of Rome, University of Twente [Netherlands], Institut de Chimie du CNRS (INC)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), University of the Basque Country [Bizkaia] (UPV/EHU), Université Nice Sophia Antipolis (... - 2019) (UNS), Pediatrics, Virology, Chappell, Elizabeth, Riordan, Andrew, Jourdain, Gonzague, Soriano-Arandes, Antoni, Ene, Luminita, J Scherpbier, Henriette, Warszawski, Josiane, J Collins, Intira, Smit, Colette, Marques, Laura, Klein, Nigel, Guillén, Sara, Judd, Ali, Thorne, Claire, Goodall, Ruth, Königs, Christoph, Spoulou, Vana, Prata, Filipa, Goetghebuer, Tessa, Chiappini, Elena, Galli, Luisa, Naver, Lar, Giaquinto, Carlo, M Gibb, Diana, Marczynska, Magdalena, Okhonskaia, Liubov, Klimkait, Thoma, Lallemant, Marc, Ngo-Giang-Huong, Nicole, Kiseleva, Galyna, Malyuta, Ruslan, Volokha, Alla, Hainaut, Marc, Delforge, Marc, Le Chenadec, Jerome, Ramos, Elisa, Dialla, Olivia, Wack, Thierry, Laurent, Corine, Ait Si Selmi, Lamya, Leymarie, Isabelle, Ait Benali, Fazia, Brossard, Maud, Boufassa, Leila, Floch-Tudal, Corinne, Firtion, Ghislaine, Hau, Isabelle, Chace, Anne, Bolot, Pascal, Blanche, Stéphane, Levine, Martine, Kremlin Bicëtre, Le, Fourcade, Corinne, Heller-Roussin, Brigitte, Runel-Belliard, Camille, Tricoire, Joëlle, Chirouze, Catherine, Reliquet, Véronique, Brouard, Jacque, Kebaili, Kamila, Fialaire, Pascale, Lalande, Muriel, Schultze-Strasser, Stephan, Baumann, U, Niehues, T, Neubert, J, Kobbe, R, Berlin, Charite, Feiterna-Sperling, C, Königs, C, Buchholz, B, Notheis, G, de Martino, Maurizio, Angelo Tovo, Pier, Patrizia, Osimani, Larovere, Domenico, Ruggeri, Maurizio, Faldella, Giacomo, Baldi, Francesco, Badolato, Raffaele, Montagnani, Carlotta, Venturini, Elisabetta, Lisi, Catiuscia, Di Biagio, Antonio, Taramasso, Lucia, Giacomet, Vania, Erba, Paola, Esposito, Susanna, Lipreri, Rita, Salvini, Filippo, Tagliabue, Claudia, Cellini, Monica, Bruzzese, Eugenia, LO VECCHIO, Andrea, Paediatric Infectious Diseases / Rheumatology / Immunology, Amsterdam institute for Infection and Immunity, AII - Infectious diseases, Amsterdam Reproduction & Development (AR&D), APH - Aging & Later Life, Infectious diseases, and Global Health
- Subjects
0301 basic medicine ,medicine.medical_treatment ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,HIV Infections ,Rate ratio ,Cohort Studies ,0302 clinical medicine ,Pregnancy ,Antiretroviral Therapy, Highly Active ,Prevalence ,030212 general & internal medicine ,Child ,poor immune response ,ddc:618 ,Immunosuppression ,Viral Load ,Hepatitis B ,Thailand ,3. Good health ,Europe ,Thailand/epidemiology ,Infectious Diseases ,Cohort ,Coinfection ,Female ,Cohort study ,Adult ,Microbiology (medical) ,viral suppression ,medicine.medical_specialty ,Adolescent ,Anti-HIV Agents ,antiretroviral therapy ,030106 microbiology ,Europe/epidemiology ,03 medical and health sciences ,children ,Acquired immunodeficiency syndrome (AIDS) ,SDG 3 - Good Health and Well-being ,Internal medicine ,medicine ,Humans ,HIV ,Aged ,Settore MED/38 - Pediatria Generale e Specialistica ,business.industry ,Immunity ,medicine.disease ,HIV Infections/drug therapy/epidemiology ,CD4 Lymphocyte Count ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,Anti-HIV Agents/therapeutic use ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Background In human immunodeficiency virus (HIV)–positive adults, low CD4 cell counts despite fully suppressed HIV-1 RNA on antiretroviral therapy (ART) have been associated with increased risk of morbidity and mortality. We assessed the prevalence and outcomes of poor immune response (PIR) in children receiving suppressive ART. Methods Sixteen cohorts from the European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) contributed data. Children Results Of 2318 children included, median age was 6.4 years and 68% had advanced/severe immunosuppression at ART initiation. At 1 year of VS, 12% had PIR. In multivariable analysis, PIR was associated with older age and worse immunological stage at ART start, hepatitis B coinfection, and residing in Thailand (all P ≤ .03). Rates of AIDS/death (95% confidence interval) per 100 000 person-years were 1052 (547, 2022) among PIR versus 261 (166, 409) among immune responders; rate ratio of 4.04 (1.83, 8.92; P < .001). Conclusions One in eight children in our cohort experienced PIR despite sustained VS. While the overall rate of AIDS/death was low, children with PIR had a 4-fold increase in risk of event as compared with immune responders.
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- 2020
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- View/download PDF
50. Maternal beta-blocker dose and risk of small-for gestational-age in women with heart disease
- Author
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Ingvil Krarup Sørbye, Randi Haualand, Henriette Wiull, Anne‐Sofie Letting, Eldrid Langesæter, and Mette‐Elise Estensen
- Subjects
Fetal Development ,Fetal Growth Retardation ,Heart Diseases ,Pregnancy ,Infant, Small for Gestational Age ,Infant, Newborn ,Obstetrics and Gynecology ,Humans ,Infant ,Female ,General Medicine ,Metoprolol - Abstract
Introduction Beta-blockers are prescribed for many pregnant women with heart disease, but whether there is a dose-dependent effect on fetal growth remains to be examined. We aimed to investigate if antenatal beta-blocker use and dose were associated with delivering a small-for-gestational-age infant among women with heart disease. Material and methods Our cohort included women with heart disease who delivered at Oslo University Hospital between 2006 and 2015. Maternal heart disease was classified into modified WHO risk scores. Women with beta-blocker treatment were dichotomized into whether they had been treated with a low or high dose based on clinical factors. We compared the risk of delivering a small-for-gestational-age infant in women exposed to high doses, low doses, or with no exposure to antenatal beta-blockers while adjusting for severity of maternal heart disease in logistic regression models. Results Of a total of 540 pregnancies among women with heart disease, 163 (30.2%) were exposed to beta-blocker treatment. The majority were treated with metoprolol (86.5%). Almost twice as many babies in the beta-blocker group were small-for-gestational-age, compared with the non-exposed group (19.8 vs 9.5%, P
- Published
- 2022
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