31 results on '"Letouzey, Mathilde"'
Search Results
2. Clinical Chorioamnionitis and Neurodevelopment at 5 Years of Age in Children Born Preterm: The EPIPAGE-2 Cohort Study
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Boileau, Pascal, Butin, Marine, Gras-Le Guen, Christèle, Kuhn, Pierre, Letouzey, Mathilde, Mitha, Ayoub, Torchin, Héloïse, Charlier, Caroline, Salmon, Fanny, Kayem, Gilles, Maisonneuve, Emeline, Foix-L’Hélias, Laurence, Benhammou, Valérie, Kaminski, Monique, Marchand-Martin, Laetitia, Kana, Gildas, Subtil, Damien, Lorthe, Elsa, and Ancel, Pierre-Yves
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- 2024
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3. Tocolysis after preterm prelabor rupture of membranes and 5-year outcomes: a population-based cohort study
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Ancel, Pierre-Yves, Arnaud, Catherine, Arthuis, Chloé, Blanc, Julie, Boileau, Pascal, Debillon, Thierry, Delorme, Pierre, D’Ercole, Claude, Desplanches, Thomas, RM, PhD., Diguisto, Caroline, Foix-L’Hélias, Laurence, Gascoin, Géraldine, Gire, Catherine, Goffinet, François, Guellec, Isabelle, Kayem, Gilles, Langer, Bruno, Letouzey, Mathilde, Lorthe, Elsa, Maisonneuve, Emeline, Marret, Stéphane, Monier, Isabelle, Morgan, Andrei, Rozé, Jean-Christophe, Schmitz, Thomas, Sentilhes, Loïc, Subtil, Damien, Torchin, Héloïse, Tosello, Barthélémy, Vayssière, Christophe, Winer, Norbert, Zeitlin, Jennifer, Marchand-Martin, Laetitia, Aubert, Adrien M., Pierrat, Véronique, Benhammou, Valérie, and L’Hélias, Laurence Foix
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- 2024
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4. Screening preterm‐born infants for autistic traits may help to identify social communication difficulties at five years of age
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Torchin, Héloise, primary, Tafflet, Muriel, additional, Charkaluk, Marie‐Laure, additional, Letouzey, Mathilde, additional, Twillhaar, Sabrina, additional, Kana, Gildas, additional, Benhammou, Valérie, additional, Marret, Stéphane, additional, Basson, Eliane, additional, Cambonie, Gilles, additional, Datin‐Dorrière, Valérie, additional, Guellec, Isabelle, additional, Lebeaux, Cécile, additional, Muller, Jean‐Baptiste, additional, Nuytten, Alexandra, additional, Kaminski, Monique, additional, Ancel, Pierre‐Yves, additional, and Pierrat, Véronique, additional
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- 2024
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5. Doxapram for apnoea of prematurity and neurodevelopmental outcomes at age 5–6 years.
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Tréluyer, Ludovic, Zana-Taieb, Elodie, Jarreau, Pierre-Henri, Benhammou, Valérie, Kuhn, Pierre, Letouzey, Mathilde, Marchand-Martin, Laetitia, Onland, Wes, Pierrat, Véronique, Saade, Lauren, Ancel, Pierre Yves, and Torchin, Héloïse
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LOW birth weight ,VERY low birth weight ,WECHSLER Intelligence Scale for Children ,NEONATAL necrotizing enterocolitis ,APNEA of prematurity ,NEONATAL sepsis ,HYPOKALEMIA - Published
- 2024
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6. Association of Chorioamnionitis with Cerebral Palsy at Two Years after Spontaneous Very Preterm Birth: The EPIPAGE-2 Cohort Study
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Arnaud, Catherine, Arthuis, Chloé, Blanc, Julie, Boileau, Pascal, Debillon, Thierry, D’Ercole, Claude, Desplanches, Thomas, Diguisto, Caroline, Garbi, Aurélie, Gascoin, Géraldine, Gire, Catherine, Langer, Bruno, Letouzey, Mathilde, Monier, RM, Isabelle, Morgan, Andrei, Rozé, Jean-Christophe, Schmitz, Thomas, Tosello, Barthélémy, Vayssiére, Christophe, Winer, Norbert, Zeitlin, Jennifer, Maisonneuve, Emeline, Lorthe, Elsa, Torchin, Héloïse, Delorme, Pierre, Devisme, Louise, L’Hélias, Laurence Foix, Marret, Stéphane, Subtil, Damien, Bodeau-Livinec, Florence, Pierrat, Véronique, Sentilhes, Loïc, Goffinet, François, Ancel, Pierre-Yves, and Kayem, Gilles
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- 2020
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7. Clinical Chorioamnionitis and Neurodevelopment at 5 Years of Age in Children Born Preterm: The EPIPAGE-2 Cohort Study
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Salmon RM, Fanny, primary, Kayem, Gilles, additional, Maisonneuve, Emeline, additional, Foix-L’Hélias, Laurence, additional, Benhammou, Valérie, additional, Kaminski, Monique, additional, Marchand-Martin, Laetitia, additional, Kana, Gildas, additional, Subtil, Damien, additional, Lorthe RM, Elsa, additional, Ancel, Pierre-Yves, additional, Letouzey, Mathilde, additional, Boileau, Pascal, additional, Butin, Marine, additional, Gras-Le Guen, Christèle, additional, Kuhn, Pierre, additional, Lorthe, Elsa, additional, Mitha, Ayoub, additional, Torchin, Héloïse, additional, and Charlier, Caroline, additional
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- 2024
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8. Tocolysis after preterm prelabor rupture of membranes and 5-year outcomes: a population-based cohort study (EPIPAGE-2)
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LORTHERM, Elsa, primary, MARCHAND-MARTIN, Laetitia, additional, LETOUZEY, Mathilde, additional, AUBERT, Adrien M., additional, PIERRAT, Véronique, additional, BENHAMMOU, Valérie, additional, DELORME, Pierre, additional, MARRET, Stéphane, additional, ANCEL, Pierre-Yves, additional, GOFFINET, François, additional, L’HÉLIAS, Laurence Foix, additional, and KAYEM, Gilles, additional
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- 2023
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9. Circumstances, causes and timing of death in extremely preterm infants admitted to NICU: The EPIPAGE‐2 study
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Boileau, Pascal, primary, Letouzey, Mathilde, additional, Morgan, Andrei S., additional, Lorthe, Elsa, additional, Kaminski, Monique, additional, Coquelin, Anaëlle, additional, Azria, Elie, additional, Caeymaex, Laurence, additional, Rouget, Florence, additional, Diguisto, Caroline, additional, Claris, Olivier, additional, Tosello, Barthélémy, additional, Truffert, Patrick, additional, Bétrémieux, Pierre, additional, Benhammou, Valérie, additional, Marchand‐Martin, Laetitia, additional, Goffinet, François, additional, Ancel, Pierre‐Yves, additional, and Foix‐L'Hélias, Laurence, additional
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- 2023
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10. Neurodevelopment at age 5.5 years according to Ages & Stages Questionnaire at 2 years’ corrected age in children born preterm: the EPIPAGE-2 cohort study
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Charkaluk, Marie-Laure, Kana, Gildas Delavoix, Benhammou, Valérie, Guellec, Isabelle, Letouzey, Mathilde, Morgan, Andrei Scott, Nuytten, Alexandra, Torchin, Héloi¨se, Twilhaar, Sabrina, Cambonie, Gilles, Marret, Stéphane, Ancel, Pierre Yves, and Pierrat, Véronique
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ObjectiveTo report neurodevelopment at age 5.5 years according to developmental delay screening with the Ages & Stages Questionnaire (ASQ) in late infancy in preterm-born children.DesignPopulation-based cohort study, EPIPAGE-2.SettingFrance, 2011–2017.Participants2504 children born at 24–26, 27–31 and 32–34 weeks, free of cerebral palsy, deafness or blindness at 2 years’ corrected age.Main outcome measuresModerate/severe, mild or no disability at age 5.5 years using gross and fine motor, sensory, cognitive and behavioural evaluations. Results of the ASQ completed between 22 and 26 months’ corrected age described as positive screening or not.ResultsAmong 2504 participants, 38.3% had ASQ positive screening. The probability of having moderate/severe or mild disability was higher for children with ASQ positive versus negative screening: 14.2% vs 7.0%, adjusted OR 2.5 (95% CI 1.8 to 3.4), and 37.6% vs 29.7%, adjusted OR 1.5 (1.2 to 1.9). For children with ASQ positive screening, the probability of having neurodevelopmental disabilities at age 5.5 years was associated with the number of domain scores below threshold, very low gestational age and severe neonatal morbidities. For children with ASQ negative screening, this probability was increased for boys and children born small-for-gestational age. For both groups, maternal level of education was strongly associated with outcomes.ConclusionIn preterm-born children, ASQ screening at 2 years’ corrected age was associated with neurodevelopmental disabilities at age 5.5 years. However, other factors should be considered when interpreting the ASQ data to draw further follow-up.Trial registration number2016-A00333-48.
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- 2024
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11. Early Antibiotic Exposure and Adverse Outcomes in Very Preterm Infants at Low Risk of Early-Onset Sepsis: The EPIPAGE-2 Cohort Study
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Letouzey, Mathilde, primary, Lorthe, Elsa, additional, Marchand-Martin, Laetitia, additional, Kayem, Gilles, additional, Charlier, Caroline, additional, Butin, Marine, additional, Mitha, Ayoub, additional, Kaminski, Monique, additional, Benhammou, Valerie, additional, Ancel, Pierre-Yves, additional, Boileau, Pascal, additional, Foix-L'Hélias, Laurence, additional, Gras-Le Guen, Christèle, additional, Kuhn, Pierre, additional, Letouzey, Mathilde, additional, Maisonneuve, Emeline, additional, Sibiude, Jeanne, additional, and Torchin, Héloïse, additional
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- 2022
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12. Reply
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Letouzey, Mathilde, primary, Foix-L'Hélias, Laurence, additional, and Lorthe, Elsa, additional
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- 2022
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13. Detection of dicentric chromosome (9;20) in paediatric B-cell acute lymphoblastic leukaemia: prognostic significance
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Letouzey, Mathilde, Penther, Dominique, Roche-Lestienne, Catherine, Nelken, Brigitte, Devoldère, Catherine, Vannier, Jean-Pierre, and Schneider, Pascale
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- 2015
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14. Ophthalmological Impairments at Five and a Half Years after Preterm Birth: EPIPAGE-2 Cohort Study
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Chapron, Thibaut, primary, Pierrat, Véronique, additional, Caputo, Georges, additional, Letouzey, Mathilde, additional, Kermorvant-Duchemin, Elsa, additional, Abdelmassih, Youssef, additional, Beaumont, William, additional, Barjol, Amandine, additional, Le Meur, Guylene, additional, Benhamou, Valérie, additional, Marchand-Martin, Laetitia, additional, Ancel, Pierre-Yves, additional, and Torchin, Héloïse, additional
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- 2022
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15. Practices and attitudes about delayed umbilical cord clamping for term infants: a descriptive survey among midwives
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Rousseau, Anne, primary, Duron, Marie-Amélie, additional, and Letouzey, Mathilde, additional
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- 2022
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16. Développement à 5 ans des enfants nés prématurés ayant bénéficié d’un dépistage à 2 ans par les questionnaires ASQ et M-CHAT : cohorte EPIPAGE-2
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Torchin, Heloise, primary, Tafflet, Muriel, additional, Ancel, Pierre-Yves, additional, Charkaluk, Marie-Laure, additional, Guellec, Isabelle, additional, Kaminski, Monique, additional, Kana, Gildas, additional, Marchand, Laetitia, additional, Marret, Stephane, additional, Nuytten, Alexandra, additional, Letouzey, Mathilde, additional, Twilhaar, Sabrina, additional, and Pierrat, Véronique, additional
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- 2022
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17. Antibiotic prophylaxis in preterm premature rupture of membranes at 24–31 weeks’ gestation: Perinatal and 2‐year outcomes in the EPIPAGE‐2 cohort
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Lorthe, Elsa, Letouzey, Mathilde, Torchin, Héloïse, Foix L'Helias, Laurence, Gras‐le Guen, Christèle, Benhammou, Valérie, Boileau, Pascal, Charlier, Caroline, Kayem, Gilles, Ancel, Pierre‐yves, Arnaud, Catherine, Blanc, Julie, Debillon, Thierry, Delorme, Pierre, D’ercole, Claude, Desplanches, Thomas, Diguisto, Caroline, Gascoin, Géraldine, Gire, Catherine, Goffinet, François, Langer, Bruno, Maisonneuve, Emeline, Marret, Stéphane, Monier, Isabelle, Morgan, Andrei, Rozé, Jean‐christophe, Schmitz, Thomas, Sentilhes, Loïc, Subtil, Damien, Tosello, Barthélémy, Vayssière, Christophe, Winer, Norbert, Zeitlin, Jennifer, Astruc, D, Kuhn, P, Matis, J, Ramousset, C, Hernandorena, X, Chabanier, P, Joly‐pedespan, L, Costedoat, Mj, Leguen, A, Lecomte, B, Lemery, D, Vendittelli, F, Beucher, G, Dreyfus, M, Guillois, B, Toure, Y, Burguet, A, Couvreur, S, Gouyon, Jb, Sagot, P, Colas, N, Sizun, J, Beuchée, A, Pladys, P, Rouget, F, Dupuy, Rp, Soupre, D, Charlot, F, Roudaut, S, Favreau, A, Saliba, E, Reboul, L, Bednarek, N, Morville, P, Verrière, V, Thiriez, G, Balamou, C, Marpeau, L, Barbier, C, Durrmeyer, X, Granier, M, Ayoubi, M, Baud, O, Carbonne, B, Jarreau, Ph, Mitanchez, D, Duffaut, C, Cornu, L, Moras, R, Boulot, P, Cambonie, G, Daudé, H, Badessi, A, Tsaoussis, N, Bédu, A, Mons, F, Bahans, C, Binet, Mh, Fresson, J, Hascoët, Jm, Milton, A, Morel, O, Vieux, R, Hilpert, L, Alberge, C, Baron, M, Charkaluk, Ml, Pierrat, V, Truffert, P, Akowanou, S, Simeoni, U, Bongain, A, Deschamps, M, Branger, B, Rouger, V, Dupont, C, Gondry, Jean, Krim, G, Baby, B, Debeir, M, Claris, O, Picaud, Jc, Rubio‐gurung, S, Cans, C, Ego, A, Patural, H, Rannaud, A, Janky, E, Poulichet, A, Rosenthal, Jm, Coliné, E, Favre, A, Joly, N, Châlons, S, Pignol, J, Laurence, Pl, Robillard, Py, Samperiz, S, Ramful, D, Blondel, B, Bonet, M, Brinis, A, Coquelin, A, Durox, M, Kaminski, M, Khemache, K, Khoshnood, B, Lebeaux, C, Marchand‐martin, L, Rousseau, J, Saurel‐cubizolles, Mj, Tran, D, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy], Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre hospitalier universitaire de Nantes (CHU Nantes), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Unité de Parasitologie-Mycologie, Service de Microbiologie [Hôpital Necker-Enfants-Malades, Paris], Assistance Publique - Hôpitaux de Paris, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service Epidémiologie clinique et santé publique [CHU Toulouse], Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Unité de biostatistiques [Centre Georges-François Leclerc], Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Médecine Néonatale et Réanimation Pédiatrique CHU Grenoble, CHU Grenoble, Service de gynécologie-obstétrique [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Service de Gynécologie Obstétrique, Médecine Foetale et Stérilité Conjugale - Chirurgie Gynécologie et Oncologique [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Service de Néonatologie, Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Recherches épidémiologiques en santé périnatale et santé des femmes, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie des Adaptations Nutritionnelles (PhAN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Groupe de Recherche sur l'Analyse Multimodale de la Fonction Cérébrale - UMR INSERM_S 1105 (GRAMFC), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Amiens-Picardie, Funding information:This work was partly supported by a postdoctoral grant from the Fondation des Treilles to EL. EPIPAGE-2 was funded by the French Institute of Public Health Research (IRESP TGIR 2009-01 programme)/Institute of Public Health and its partners: the French Health Ministry, the National Institute of Health and Medical Research (INSERM), the National Institute of Cancer, and the National Solidarity Fund for Autonomy (CNSA), the National Research Agency through the French EQUIPEX programme of investments for the future (grant number ANR-11-EQPX-0038), and the PREMUP Foundation. Additional funding was obtained from Fondation pour la Recherche Medicale (grant number SPF 20160936356) and Fondation de France (grant numbers 00050329, Grand Prix R18202KK]). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript., ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Education, Formation, Travail, Savoirs (EFTS), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), Centre Hospitalier Universitaire [Grenoble] (CHU), Modélisation et Évaluation des données complexes en Santé Publique (TIMC-MESP), Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC ), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), CHU Dijon, Hôpital Nord [CHU - APHM], Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Department of Obstetrics and Gynecology, Les Hôpitaux Universitaires de Strasbourg (HUS), EPIPAGE-2 Study Group, and Institut National de la Santé et de la Recherche Médicale (INSERM)
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Fetal Membranes, Premature Rupture ,obstetric intervention ,[SDV]Life Sciences [q-bio] ,Gestational Age ,antenatal management ,Cohort Studies ,Pregnancy ,Escherichia coli ,Humans ,Prospective Studies ,latency ,amoxicillin ,neurodevelopment ,macrolides ,prematurity ,Infant, Newborn ,Pregnancy Outcome ,Obstetrics and Gynecology ,Infant ,prophylactic antibiotics ,Antibiotic Prophylaxis ,Anti-Bacterial Agents ,perinatal outcome ,cephalosporins ,Premature Birth ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Neonatal Sepsis ,Infant, Premature - Abstract
To compare different antibiotic prophylaxis administered after preterm premature rupture of membranes to determine whether any were associated with differences in obstetric and/or neonatal outcomes and/or neurodevelopmental outcomes at 2 years of corrected age.Prospective, nationwide, population-based EPIPAGE-2 cohort study of preterm infants.France, 2011.We included 492 women with a singleton pregnancy and a diagnosis of preterm premature rupture of membranes at 24-31 weeks. Exclusion criteria were contraindication to expectant management or indication for antibiotic therapy other than preterm premature rupture of membranes. Antibiotic prophylaxis was categorised as amoxicillin (n = 345), macrolide (n = 30), third-generation cephalosporin (n = 45) or any combinations covering Streptococcus agalactiae and90% of Escherichia coli (n = 72), initiated within 24 hours after preterm premature rupture of membranes.Population-averaged robust Poisson models.Survival at discharge without severe neonatal morbidity, 2-year neurodevelopment.With amoxicillin, macrolide, third-generation cephalosporin and combinations, 78.5%, 83.9%, 93.6% and 86.0% of neonates were discharged alive without severe morbidity. The administration of third-generation cephalosporin or any E. coli-targeting combinations was associated with improved survival without severe morbidity (adjusted risk ratio 1.25 [95% confidence interval 1.08-1.45] and 1.10 [95 % confidence interval 1.01-1.20], respectively) compared with amoxicillin. We evidenced no increase in neonatal sepsis related to third-generation cephalosporin-resistant pathogen.In preterm premature rupture of membranes at 24-31 weeks, antibiotic prophylaxis based on third-generation cephalosporin may be associated with improved survival without severe neonatal morbidity when compared with amoxicillin, with no evidence of increase in neonatal sepsis related to third-generation cephalosporin-resistant pathogen.Antibiotic prophylaxis after PPROM at 24-31 weeks: 3rd-generation cephalosporins associated with improved neonatal outcomes.
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- 2022
18. Association of early antibiotic exposure and necrotizing enterocolitis: causality or confounding bias?
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Letouzey, Mathilde, primary, Foix-L'Hélias, Laurence, additional, Boileau, Pascal, additional, and Lorthe, Elsa, additional
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- 2020
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19. Tocolysis after preterm prelabor rupture of membranes and 5-year outcomes: a population-based cohort study.
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Lorthe, Elsa, Marchand-Martin, Laetitia, Letouzey, Mathilde, Aubert, Adrien M., Pierrat, Véronique, Benhammou, Valérie, Delorme, Pierre, Marret, Stéphane, Ancel, Pierre-Yves, Goffinet, François, L'Hélias, Laurence Foix, and Kayem, Gilles
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PREMATURE rupture of fetal membranes ,PREGNANT women ,NEONATAL death ,APRAXIA ,COHORT analysis - Abstract
The administration of tocolytics after preterm prelabor rupture of membranes remains a controversial practice. In theory, reducing uterine contractility should delay delivery and allow for optimal antenatal management, thereby reducing the risks for prematurity and adverse consequences over the life course. However, tocolysis may be associated with neonatal death or long-term adverse neurodevelopmental outcomes, mainly related to prolonged fetal exposure to intrauterine infection or inflammation. In a previous study, we showed that tocolysis administration was not associated with short-term benefits. There are currently no data available to evaluate the impact of tocolysis on neurodevelopmental outcomes in school-aged children born prematurely in this clinical setting. This study aimed to investigate whether tocolysis administered after preterm prelabor rupture of membranes is associated with neurodevelopmental outcomes at 5.5 years of age. We used data from a prospective, population-based cohort study of preterm births recruited in 2011 (referred to as the EPIPAGE-2 study) and for whom the results of a comprehensive medical and neurodevelopmental assessment of the infant at age 5.5 years were available. We included pregnant individuals with preterm prelabor rupture of membranes at 24 to 32 weeks' gestation in singleton pregnancies with a live fetus at the time of rupture, birth at 24 to 34 weeks' gestation, and participation of the infant in an assessment at 5.5 years of age. Exposure was the administration of any tocolytic treatment after preterm prelabor rupture of membranes. The main outcome was survival without moderate to severe neurodevelopmental disabilities at 5.5 years of age. Secondary outcomes included survival without any neurodevelopmental disabilities, cerebral palsy, full-scale intelligence quotient, developmental coordination disorders, and behavioral difficulties. A propensity-score analysis was used to minimize the indication bias in the estimation of the treatment effect on outcomes. Overall, 596 of 803 pregnant individuals (73.4%) received tocolytics after preterm prelabor rupture of membranes. At the 5.5-year follow-up, 82.7% and 82.5% of the children in the tocolysis and no tocolysis groups, respectively, were alive without moderate to severe neurodevelopmental disabilities; 52.7% and 51.1%, respectively, were alive without any neurodevelopmental disabilities. After applying multiple imputations and inverse probability of treatment weighting, we found no association between the exposure to tocolytics and survival without moderate to severe neurodevelopmental disabilities (odds ratio, 0.93; 95% confidence interval, 0.55–1.60), survival without any neurodevelopmental disabilities (odds ratio, 1.02; 95% confidence interval, 0.65–1.61), or any of the other outcomes. There was no difference in the neurodevelopmental outcomes at age 5.5 years among children with and without antenatal exposure to tocolysis after preterm prelabor rupture of membranes. To date, the health benefits of tocolytics remain unproven, both in the short- and long-term. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2024
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20. Association between extremely preterm caesarean delivery and maternal depressive and anxious symptoms: a national population‐based cohort study
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Blanc, J, primary, Rességuier, N, additional, Lorthe, E, additional, Goffinet, F, additional, Sentilhes, L, additional, Auquier, P, additional, Tosello, B, additional, d'Ercole, C, additional, Ancel, Pierre‐Yves, additional, Arnaud, Catherine, additional, Blanc, Julie, additional, Boileau, Pascal, additional, Debillon, Thierry, additional, Delorme, Pierre, additional, D’Ercole, Claude, additional, Desplanches, Thomas, additional, Diguisto, Caroline, additional, Foix‐L’Hélias, Laurence, additional, Garbi, Aurélie, additional, Gascoin, Géraldine, additional, Gaudineau, Adrien, additional, Gire, Catherine, additional, Goffinet, François, additional, Kayem, Gilles, additional, Langer, Bruno, additional, Letouzey, Mathilde, additional, Lorthe, Elsa, additional, Maisonneuve, Emeline, additional, Marret, Stéphane, additional, Monier, Isabelle, additional, Morgan, Andrei, additional, Rozé, Jean‐Christophe, additional, Schmitz, Thomas, additional, Sentilhes, Loïc, additional, Subtil, Damien, additional, Torchin, Héloïse, additional, Tosello, Barthélémy, additional, Vayssière, Christophe, additional, Winer, Norbert, additional, and Zeitlin, Jennifer, additional
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- 2020
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21. Association of Chorioamnionitis with Cerebral Palsy at Two Years after Spontaneous Very Preterm Birth: The EPIPAGE-2 Cohort Study
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Maisonneuve, Emeline, primary, Lorthe, Elsa, additional, Torchin, Héloïse, additional, Delorme, Pierre, additional, Devisme, Louise, additional, L’Hélias, Laurence Foix, additional, Marret, Stéphane, additional, Subtil, Damien, additional, Bodeau-Livinec, Florence, additional, Pierrat, Véronique, additional, Sentilhes, Loïc, additional, Goffinet, François, additional, Ancel, Pierre-Yves, additional, Kayem, Gilles, additional, Arnaud, Catherine, additional, Arthuis, Chloé, additional, Blanc, Julie, additional, Boileau, Pascal, additional, Debillon, Thierry, additional, D’Ercole, Claude, additional, Desplanches, Thomas, additional, Diguisto, Caroline, additional, Garbi, Aurélie, additional, Gascoin, Géraldine, additional, Gire, Catherine, additional, Langer, Bruno, additional, Letouzey, Mathilde, additional, Monier, RM, Isabelle, additional, Morgan, Andrei, additional, Rozé, Jean-Christophe, additional, Schmitz, Thomas, additional, Tosello, Barthélémy, additional, Vayssiére, Christophe, additional, Winer, Norbert, additional, and Zeitlin, Jennifer, additional
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- 2020
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22. Cause of preterm birth and late-onset sepsis in very preterm infants: the EPIPAGE-2 cohort study.
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Letouzey, Mathilde, Foix-L'Hélias, Laurence, Torchin, Héloïse, Mitha, Ayoub, Morgan, Andrei S., Zeitlin, Jennifer, Kayem, Gilles, Maisonneuve, Emeline, Delorme, Pierre, Khoshnood, Babak, Kaminski, Monique, Ancel, Pierre-Yves, Boileau, Pascal, Lorthe, Elsa, The EPIPAGE-2 Working Group on Infections, Gras-Le Guen, Christèle, Kuhn, Pierre, and EPIPAGE-2 Working Group on Infections
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- 2021
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23. Severe apparently isolated fetal ventriculomegaly and neurodevelopmental outcome
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Letouzey, Mathilde, Chadie, Alexandra, Brasseur-Daudruy, Marie, Proust, François, Verspyck, Eric, Boileau, Pascal, Marret, Stéphane, Service d'imagerie médicale [CHU Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service de neurochirurgie [CHU Rouen], CHU Rouen, Service de gynécologie et obstétrique [CHU Rouen], Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, PremUp Foundation, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Descartes - Paris 5 (UPD5)-CHI Créteil-Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7), Team 4 'NeoVasc' - INSERM U1245, Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'imagerie médicale [Rouen], Normandie Université (NU)-Normandie Université (NU)-Hôpital Charles Nicolle [Rouen]-Université de Rouen Normandie (UNIROUEN), Service de neurochirurgie [Rouen], Service de gynécologie et obstétrique [Rouen], Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Universités-Université Paris Descartes - Paris 5 (UPD5)-CHI Créteil-Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7), Hôpital Charles Nicolle [Rouen], Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-CHI Créteil-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Team 4 NeoVasc - Region Team ERI 28 INSERM (Neovasc)
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[SDV]Life Sciences [q-bio] ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2017
24. Position des sages-femmes sur la décision de réanimation active des extrêmes prématurés à la limite de viabilité en salle de naissance
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Shamri, Adèle, primary, Baumann, Sophie, additional, Boileau, Pascal, additional, and Letouzey, Mathilde, additional
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- 2018
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25. Massive congenital depression of neonate’s skull
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Letouzey, Mathilde, primary and Berveiller, Paul, additional
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- 2018
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26. Detection of dicentric chromosome (9;20) in paediatric B-cell acute lymphoblastic leukaemia: prognostic significance
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Letouzey, Mathilde, primary, Penther, Dominique, additional, Roche-Lestienne, Catherine, additional, Nelken, Brigitte, additional, Devoldère, Catherine, additional, Vannier, Jean-Pierre, additional, and Schneider, Pascale, additional
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- 2014
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27. Early antibiotic exposure and adverse outcomes in very preterm infants at low risk of early-onset sepsis: the EPIPAGE-2 cohort study
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Mathilde Letouzey, Elsa Lorthe, Laetitia Marchand-Martin, Gilles Kayem, Caroline Charlier, Marine Butin, Ayoub Mitha, Monique Kaminski, Valerie Benhammou, Pierre-Yves Ancel, Pascal Boileau, Laurence Foix-L'Hélias, Christèle Gras-Le Guen, Pierre Kuhn, Emeline Maisonneuve, Jeanne Sibiude, Héloïse Torchin, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy], Geneva University Hospitals and Geneva University, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Immunobiologie de l'Infection - Immunobiology of Infection, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre collaborateur de l'OMS Listeria / WHO Collaborating Centre Listeria (CC-OMS / WHO-CC), Institut Pasteur [Paris] (IP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Université Paris Cité (UPCité), Biologie des Infections - Biology of Infection, Centre National de Référence Listeria - National Reference Center Listeria (CNRL), Hospices Civils de Lyon (HCL), Hôpital Jeanne de Flandres, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CIC - Mère Enfant Necker Cochin Paris Centre (CIC 1419), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), he EPIPAGE-2 study was funded by the French Institute of Public Health Research/Institute of Public Health and its partners: the French Health Ministry, National Institute of Health and Medical Research (Inserm), National Institute of Cancer, and National Solidarity Fund for Autonomy (CNSA). Additional support for this study was provided by the National Research Agency through the French EquipEx 'Investments in the Future' Program (ANR-11-EQPX-0038 and ANR-19-COHO-001), the PREMUP Foundation, Fondation de France (11779), and Fondation pour la Recherche M edicale (SPF20160936356). The funding sources had no role in the design and conduct of the study, collection, management, analysis, and interpretation of the data, preparation, review, or approval of the manuscript, or the decision to submit the manuscript for publication. The authors declare no conflicts of interest., ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), ANR-19-COHO-0001,RE-CO-NAI (COHORTES),Resarch platform on cohorts of children followed from birth(2019), LETOUZEY, Mathilde, Equipements d'excellence - Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance - - RE-CO-NAI2011 - ANR-11-EQPX-0038 - EQPX - VALID, Resarch platform on cohorts of children followed from birth - - RE-CO-NAI (COHORTES)2019 - ANR-19-COHO-0001 - COHO - VALID, and Centre National de Référence Listeria - National Reference Center Listeria (CNR)
- Subjects
neonatal death ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,necrotizing enterocolitis ,prematurity ,preterm birth ,severe cerebral lesions ,empirical antibiotics ,neonatal outcome ,[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Pediatrics, Perinatology and Child Health ,late-onset sepsis ,bronchopulmonary dysplasia ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie - Abstract
International audience; Objective: To assess the association between early empirical antibiotics and neonatal adverse outcomes in very preterm infants without risk factors of early-onset sepsis.Study design: This is a secondary analysis of the EPIPAGE-2 study, a prospective national population-based cohort that included all liveborn infants at 22-31 completed weeks of gestation in France in 2011. Infants at high risk of early-onset sepsis (born after preterm labor or preterm premature rupture of membranes, or from mother who had clinical chorioamnionitis or received antibiotics during the last 72 hours) were excluded. Early antibiotic exposure was defined as antibiotics started at Day 0 or Day 1 of life, regardless of the duration and type of antibiotics. We compared treated and untreated patients by using inverse probability of treatment weighting based on estimated propensity score. Results: Among 648 very preterm infants at low risk of early-onset sepsis, 173 (26.2%) had early antibiotics treatment. Early antibiotic exposure was not associated with death or late-onset sepsis or necrotizing enterocolitis (OR=1.04 [95%CI=0.72-1.50]). However, it was associated with higher odds of severe cerebral lesions (OR=2.71 [95%CI=1.25-5.86]) and moderate-to-severe bronchopulmonary dysplasia (OR=2.30 [95%CI=1.21-4.38]). Conclusion: Early empirical antibiotics administrated in very preterm infants at low risk of early-onset sepsis were associated with a higher risk of severe cerebral lesions and moderate-to-severe bronchopulmonary dysplasia.
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- 2022
28. Cause of preterm birth and late-onset sepsis in very preterm infants: the EPIPAGE-2 cohort study
- Author
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Héloïse Torchin, Laurence Foix-L'Hélias, Jennifer Zeitlin, Elsa Lorthe, Babak Khoshnood, Monique Kaminski, Ayoub Mitha, Mathilde Letouzey, Pascal Boileau, Pierre-Yves Ancel, Andrei S. Morgan, Emeline Maisonneuve, Pierre Delorme, Gilles Kayem, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy], CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Jeanne de Flandres, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), University College of London [London] (UCL), CIC - Mère Enfant Necker Cochin Paris Centre (CIC 1419), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université Paris-Saclay, Geneva University Hospitals and Geneva University, EPIPAGE-2 Working Group on Infections: Pascal Boileau, Laurence Foix-L'Hélias, Christèle Gras-Le Guen, Gilles Kayem, Pierre Kuhn, Mathilde Letouzey, Emeline Maisonneuve, Ayoub Mitha, Héloïse Torchin, and LETOUZEY, Mathilde
- Subjects
Adult ,medicine.medical_specialty ,Population ,Infant, Premature, Diseases ,Cohort Studies ,Sepsis ,03 medical and health sciences ,0302 clinical medicine ,[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics ,Pregnancy ,030225 pediatrics ,medicine ,Humans ,education ,Survival analysis ,Clinical Research Article ,education.field_of_study ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,Fetal Growth Retardation ,Placental abruption ,Proportional hazards model ,Obstetrics ,business.industry ,Hazard ratio ,Infant, Newborn ,medicine.disease ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Pediatrics, Perinatology and Child Health ,Premature Birth ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,Premature rupture of membranes ,Infant, Premature ,030217 neurology & neurosurgery ,Cohort study - Abstract
International audience; Background: The pathogenesis of late-onset sepsis (LOS) in preterm infants is poorly understood and knowledge about risk factors, especially prenatal risk factors, is limited. This study aimed to assess the association between the cause of preterm birth and LOS in very preterm infants.Methods: 2052 very preterm singletons from a national population-based cohort study alive at 72 h of life were included. Survival without LOS was compared by cause of preterm birth using survival analysis and Cox regression models.Results: 437 (20.1%) had at least one episode of LOS. The frequency of LOS varied by cause of preterm birth: 17.1% for infants born after preterm labor, 17.9% after preterm premature rupture of membranes, 20.3% after a placental abruption, 20.3% after isolated hypertensive disorders, 27.5% after hypertensive disorders with fetal growth restriction (FGR), and 29.4% after isolated FGR. In multivariate analysis, when compared to infants born after preterm labor, the risk remained higher for infants born after hypertensive disorders (hazard ratio HR = 1.7, 95% CI = 1.2-2.5), hypertensive disorders with FGR (HR = 2.6, 95% CI = 1.9-3.6) and isolated FGR (HR = 2.9, 95% CI = 1.9-4.4).Conclusion: Very preterm infants born after hypertensive disorders or born after FGR had an increased risk of LOS compared to those born after preterm labor.Impact: Late-onset sepsis risk differs according to the cause of preterm birth. Compared with those born after preterm labor, infants born very preterm because of hypertensive disorders of pregnancy and/or fetal growth restriction display an increased risk for late-onset sepsis. Antenatal factors, in particular the full spectrum of causes leading to preterm birth, should be taken into consideration to better prevent and manage neonatal infectious morbidity and inform the parents.
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- 2021
29. Antibiotic prophylaxis in preterm premature rupture of membranes at 24-31 weeks' gestation: Perinatal and 2-year outcomes in the EPIPAGE-2 cohort.
- Author
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Lorthe E, Letouzey M, Torchin H, Foix L'Helias L, Gras-Le Guen C, Benhammou V, Boileau P, Charlier C, and Kayem G
- Subjects
- Amoxicillin therapeutic use, Anti-Bacterial Agents therapeutic use, Antibiotic Prophylaxis, Cephalosporins, Cohort Studies, Escherichia coli, Female, Gestational Age, Humans, Infant, Infant, Newborn, Infant, Premature, Macrolides, Pregnancy, Pregnancy Outcome, Prospective Studies, Fetal Membranes, Premature Rupture prevention & control, Neonatal Sepsis, Premature Birth prevention & control
- Abstract
Objective: To compare different antibiotic prophylaxis administered after preterm premature rupture of membranes to determine whether any were associated with differences in obstetric and/or neonatal outcomes and/or neurodevelopmental outcomes at 2 years of corrected age., Design: Prospective, nationwide, population-based EPIPAGE-2 cohort study of preterm infants., Setting: France, 2011., Sample: We included 492 women with a singleton pregnancy and a diagnosis of preterm premature rupture of membranes at 24-31 weeks. Exclusion criteria were contraindication to expectant management or indication for antibiotic therapy other than preterm premature rupture of membranes. Antibiotic prophylaxis was categorised as amoxicillin (n = 345), macrolide (n = 30), third-generation cephalosporin (n = 45) or any combinations covering Streptococcus agalactiae and >90% of Escherichia coli (n = 72), initiated within 24 hours after preterm premature rupture of membranes., Methods: Population-averaged robust Poisson models., Main Outcome Measures: Survival at discharge without severe neonatal morbidity, 2-year neurodevelopment., Results: With amoxicillin, macrolide, third-generation cephalosporin and combinations, 78.5%, 83.9%, 93.6% and 86.0% of neonates were discharged alive without severe morbidity. The administration of third-generation cephalosporin or any E. coli-targeting combinations was associated with improved survival without severe morbidity (adjusted risk ratio 1.25 [95% confidence interval 1.08-1.45] and 1.10 [95 % confidence interval 1.01-1.20], respectively) compared with amoxicillin. We evidenced no increase in neonatal sepsis related to third-generation cephalosporin-resistant pathogen., Conclusion: In preterm premature rupture of membranes at 24-31 weeks, antibiotic prophylaxis based on third-generation cephalosporin may be associated with improved survival without severe neonatal morbidity when compared with amoxicillin, with no evidence of increase in neonatal sepsis related to third-generation cephalosporin-resistant pathogen., Tweetable Abstract: Antibiotic prophylaxis after PPROM at 24-31 weeks: 3rd-generation cephalosporins associated with improved neonatal outcomes., (© 2022 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd.)
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- 2022
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30. Assessment and care of the newborn at term
- Author
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Letouzey M, Foix-L'Hélias L, Castel C, and Boileau P
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- Humans, Infant, Newborn, Neonatal Screening
- Abstract
Competing Interests: M. Letouzey, L. Foix-L’Hélias, C. Castel et P. Boileau déclarent n’avoir aucun lien d’intérêts.
- Published
- 2017
31. Severe apparently isolated fetal ventriculomegaly and neurodevelopmental outcome.
- Author
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Letouzey M, Chadie A, Brasseur-Daudruy M, Proust F, Verspyck E, Boileau P, and Marret S
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- Adult, Child, Child Development, Female, France epidemiology, Humans, Hydrocephalus diagnostic imaging, Hydrocephalus epidemiology, Infant, Newborn, Nervous System growth & development, Neurodevelopmental Disorders epidemiology, Pregnancy, Retrospective Studies, Ultrasonography, Prenatal, Hydrocephalus complications, Neurodevelopmental Disorders etiology
- Abstract
Objective: Our aim is to assess the neurodevelopmental outcome of children with a prenatal diagnosis of apparently isolated severe ventriculomegaly (SVM)., Method: This is a retrospective cohort study from 1994 to 2011. We included fetuses with unilateral or bilateral ventriculomegaly equal to or greater than 15 mm at prenatal ultrasound and confirmed by magnetic resonance imaging, whose parents chose continuation of pregnancy past 22 weeks, and with no associated findings at diagnosis (i.e. no brain malformation or cerebral lesions, normal karyotype, no other congenital abnormalities by ultrasound, and negative toxoplasma, rubella, cytomegalovirus, and herpes test. Children were followed up for at least 2 years. Children were classified into three groups: normal, moderate, or severe abnormalities according to psychomotor developmental stages and/or a visual or hearing impairment and/or behavioral disorders., Results: Twenty-one patients fulfilled the study criteria. SVM was diagnosed at an average gestational age of 30 weeks (range 22-37 weeks). Head circumference was >95th centile in 39% of them. The etiology of SVM was intraventricular hemorrhage in 6 (29%), stenosis of the aqueduct of Sylvius in 3 (14%), and undetermined in 12 (57%). Neurosurgery was performed in four infants, and ventriculoperitoneal shunts were inserted in three. At a mean age at last follow-up of 8.4 years, neurodevelopmental outcome was normal in 62% and moderate and severely impaired in 14% and 24% of children, respectively. There was no association between neurologic outcome and severity of ventricular dilation at prenatal imaging, gestational age at initial diagnosis of SVM, or etiology of the ventricular dilatation., Conclusion: The majority of children with apparently isolated SVM show normal neurodevelopmental outcome. No prenatal risk factor identify cases at higher risk for severely abnormal neurologic outcome. © 2017 John Wiley & Sons, Ltd., (© 2017 John Wiley & Sons, Ltd.)
- Published
- 2017
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