139 results on '"Lesuisse, Dominique"'
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2. Increasing Brain Exposure of Antibodies
3. Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development
4. Increasing Brain Exposure of Antibodies
5. Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model
6. An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family
7. Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development
8. List of Contributors
9. Preparation of Water-Soluble Compounds by Covalent Attachment of Solubilizing Moieties
10. Search and Characterization of ITM2A as a New Potential Target for Brain Delivery
11. Peptidomics of Haemonchus contortus
12. Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development.
13. Discovery of Original Tricyclic Imidazopyridines during a Search for Nurr1 Nuclear Receptor Agonists
14. Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease
15. Non-Human Primate Blood–Brain Barrier and In Vitro Brain Endothelium: From Transcriptome to the Establishment of a New Model
16. Brain Delivery of Single-Domain Antibodies: A Focus on VHH and VNAR
17. Design of Potent IGF1-R Inhibitors Related to Bis-azaindoles
18. Dominique Lesuisse, Ph.D.
19. Data on synthesis, ADME and pharmacological properties and early safety pharmacology evaluation of a series of novel NURR1/NOT agonist potentially useful for the treatment of Parkinson's disease
20. Améliorer le ciblage tissulaire des anticorps thérapeutiques par de nouveaux formats
21. High-affinity Src-SH2 ligands which do not activate Tyr 527-phosphorylated Src in an experimental in vivo system
22. Chapter 30 - Preparation of Water-Soluble Compounds by Covalent Attachment of Solubilizing Moieties
23. Rhodium(III)-Catalyzed C–H Activation/Heterocyclization as a Macrocyclization Strategy. Synthesis of Macrocyclic Pyridones
24. Harnessing C−H Activation of Benzhydroxamates as a Macrocyclization Strategy: Synthesis of Structurally Diverse Macrocyclic Isoquinolones
25. Discovery of the first non-ATP competitive IGF-1R kinase inhibitors: Advantages in comparison with competitive inhibitors
26. Design of potent and selective GSK3β inhibitors with acceptable safety profile and pharmacokinetics
27. Rational design of potent GSK3β inhibitors with selectivity for Cdk1 and Cdk2
28. Efficient and Modular Synthesis of New Structurally Diverse Functionalized [n]Paracyclophanes by a Ring-Distortion Strategy
29. ChemInform Abstract: Discovery of Thioazepinone Ligands for Src SH2: From Non-specific to Specific Binding.
30. ChemInform Abstract: Imidazole-Based Ligands of the Src SH2 Protein.
31. Requirements for Specific Binding of Low Affinity Inhibitor Fragments to the SH2 Domain of pp60Src Are Identical to Those for High Affinity Binding of Full Length Inhibitors
32. High-affinity Src-SH2 ligands which do not activate Tyr527-phosphorylated Src in an experimental in vivo system
33. Principles Governing the Binding of a Class of Non-Peptidic Inhibitors to the SH2 Domain of src Studied by X-ray Analysis
34. SAR and X-ray. A New Approach Combining Fragment-Based Screening and Rational Drug Design: Application to the Discovery of Nanomolar Inhibitors of Src SH2
35. Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein
36. Imidazole-based ligands of the Src SH2 protein
37. Discovery of highly potent Src SH2 binders: Structure–activity studies and X-ray structures
38. ChemInform Abstract: Biphenyls as Surrogates of the Steroidal Backbone. Part 1. Synthesis and Estrogen Receptor Affinity of an Original Series of Polysubstituted Biphenyls.
39. ChemInform Abstract: Biphenyls as Surrogates of the Steroidal Backbone. Part 2. Discovery of a Novel Family of Non‐steroidal 5‐α‐Reductase Inhibitors.
40. Discovery of Thioazepinone Ligands for Src SH2: From Non-specific to Specific Binding
41. Biphenyls as Surrogates of the Steroidal Backbone. Part 2: Discovery of a Novel Family of Non-steroidal 5-α-Reductase Inhibitors
42. Biphenyls as surrogates of the steroidal backbone. Part 1: synthesis and estrogen receptor affinity of an original series of polysubstituted biphenyls
43. Src homology-2 domain binding assays by scintillation proximity and surface plasmon resonance
44. Structure−Activity Relationships of a New Family of Steroidal Aromatase Inhibitors. 1. Synthesis and Evaluation of a Series of Analogs Related to 19-[(Methylthio)methyl]androstenedione (RU54115)
45. Au-delà de la pulsion de mort ?
46. Small ligands interacting with the phosphotyrosine binding pocket of the Src SH 2 protein
47. Discovery of highly potent Src SH 2 binders: Structure–activity studies and X-ray structures
48. Imidazole-based ligands of the Src SH 2 protein
49. Uncatalyzed and chorismate mutase-catalyzed Claisen rearrangement of (Z)-9-methylchorismic acid
50. (-)-Methyl 4,5-O-benzylidene-4-epi-shikimate: an intermediate for the synthesis of (-)-chorismic acid and analogs
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