23 results on '"Lessing Y"'
Search Results
2. Délai du rétablissement de la continuité colorectale après intervention de Hartmann pour diverticulite perforée
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Horesh, N., Lessing, Y., Rudnicki, Y., Kent, I., Kammar, H., Ben-Yaacov, A., Dreznik, Y., Zbar, A.P., Tulchinsky, H., Avital, S., Mavor, E., Kashtan, H., Klausner, J.M., Gutman, M., Zmora, O., and Wasserberg, N.
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- 2020
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3. Synchronous Hartmann reversal and incisional hernia repair is associated with higher complication rate compared to a staged procedure
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Rudnicki, Y., Horesh, N., Lessing, Y., Tverskov, V., Wachtel, A., Slavin, M., Tulchinsky, H., Wasserberg, N., Mavor, E., Zmora, O., and Avital, S.
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- 2021
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4. Solid pseudopapillary neoplasm of the pancreas: Management and long-term outcome
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Lubezky, N., primary, Papoulas, M., additional, Lessing, Y., additional, Gitstein, G., additional, Brazowski, E., additional, Nachmany, I., additional, Lahat, G., additional, Goykhman, Y., additional, Ben-Yehuda, A., additional, Nakache, R., additional, and Klausner, J.M., additional
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- 2017
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5. ICG-guided sentinel lymph node biopsy in melanoma is as effective as blue dye: A retrospective analysis.
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Lavy D, Shimonovitz M, Keidar D, Warshavsky A, Lessing Y, Abu-Abeid A, Schneebaum S, Miodovnik M, and Nizri E
- Abstract
Introduction: Sentinel lymph node biopsy (SLNB) is a key procedure in the staging and management of melanoma. Traditionally, it is performed using a dual-mapping technique combining a radioactive isotope (RI) and blue dye (BD). Fluorescence-guided surgery with indocyanine green (ICG) has emerged as an alternative tracer, offering potential advantages in real-time visualization and operative efficiency. This study compares the efficacy of RI + ICG with RI + BD in SLNB for melanoma., Methods: We conducted a retrospective cohort study at a single center, including 311 patients who underwent SLNB for melanoma. Patients were divided into two groups: RI + BD (n = 227, January 2010-August 2022) and RI + ICG (n = 84, August 2022-February 2024). SLN detection rates, positive SLN rates, operative times, and postoperative complications were compared between the two groups., Results: Both groups were clinically and pathologically comparable. SLN detection rates were 100 % in the RI + BD group and 98.8 % in the RI + ICG group (p = 0.1). The median number of lymph nodes resected was lower in the RI + ICG group as compared to the RI + BD group (p = 0.047). While positive SLN rates were higher in the RI + ICG group (9.5 % vs. 6.2 %), this difference was not statistically significant (p = 0.3). ICG alone could not identify all the positive SLN. Postoperative complications, including seroma, did not differ significantly between groups., Conclusions: ICG-guided SLNB is comparable to BD-guided SLNB in terms of detection rate and SLN positivity, although it can not be used alone to identify all positive SLNBs. ICG-based fluorescence imaging is a promising technique that may enhance surgical efficiency in melanoma management., (Copyright © 2024. Published by Elsevier Ltd.)
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- 2024
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6. Esophagogastric cancer surgery characteristics and outcomes in bariatric patients, compared with non-bariatric patients.
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Lessing Y, Abu-Abeid A, Falk E, Lahat G, Nizri E, and Dayan D
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- Humans, Male, Female, Middle Aged, Retrospective Studies, Aged, Treatment Outcome, Body Mass Index, Gastrectomy, Postoperative Complications epidemiology, Esophagectomy, Age Factors, Obesity, Morbid surgery, Bariatric Surgery, Esophageal Neoplasms surgery, Esophageal Neoplasms pathology, Stomach Neoplasms surgery, Stomach Neoplasms pathology
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Background: The association between bariatric surgery and esophagogastric cancer (EGC) is debated. This study aimed to assess EGC characteristics and surgery outcomes comparing bariatric and non-bariatric patients., Methods: Single-center retrospective analysis of prospective EGC surgery database., Results: EGC-surgery was performed in 269 patients, classified as bariatric (N.=10, 3.3%), and non-bariatric (N.=259, 96.6%) groups. Non-bariatric group was sub-classified into body mass index (BMI) <35 kg/m
2 (N.=244) and >35 kg/m2 (N.=15). BMI was 35.3±5.6 vs. 25.7±16.1 and 37.8±8.7 kg/m2 in bariatric vs. non-bariatric-BMI <35 and >35, respectively (P<0.001). Bariatric patients were significantly younger (56.75±11 vs. 71±10 and 68.38±8.2 years; P<0.001). They tended to have lower rates of diabetes mellitus (30% vs. 43.9% and 73.3%; P=0.05) and significantly lower hypertension rates (50%, vs.86.5% and 93.3%, P<0.004). Bariatric procedures were performed 11.3 years (IQR 5.5-16.5) prior to EGC-surgery. Tumor characteristics were statistically comparable except a significantly higher number of positive LN in the bariatric group (6.9±13.6 vs. 2.7±4.9 and 1.9±4.8; P=0.006), and more bariatric patients received adjuvant treatment (P=0.035). Postoperative major complication rates (0% vs. 25.8%, and 33.3%; P=0.14) and length of hospital stay (14.1±15.3, vs. 23±28.5, and 21±18 days; P=0.59) were comparable. There was no significant difference in Disease- free survival (P=0.42) or overall survival (P=0.48) between patient-groups., Conclusions: Bariatric patients were diagnosed with EGC at a younger age, and tended to have worse nodal involvement. Although outcomes were comparable, clinical and endoscopic surveillance seem important as EGC can occur 10 years or earlier than in non-bariatric patients.- Published
- 2024
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7. Primary Versus Revisional Bariatric and Metabolic Surgery in Patients with a Body Mass Index ≥ 50 kg/m 2 -90-Day Outcomes and Risk of Perioperative Mortality.
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Abu-Abeid A, Dvir N, Lessing Y, Eldar SM, Lahat G, Keidar A, and Yuval JB
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- Humans, Female, Male, Retrospective Studies, Adult, Middle Aged, Treatment Outcome, Body Mass Index, Reoperation statistics & numerical data, Obesity, Morbid surgery, Obesity, Morbid complications, Bariatric Surgery statistics & numerical data, Postoperative Complications mortality, Postoperative Complications epidemiology
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Background: Bariatric and metabolic surgery (BMS) is an effective treatment for patients with severe obesity. Patients with higher body mass index (BMI) and patients undergoing revisional surgery have a higher rate of major complications. This study purpose is to evaluate perioperative outcomes of patients with BMI ≥ 50 kg/m
2 ., Materials and Methods: A retrospective analysis of patients with a BMI ≥ 50 kg/m2 undergoing BMS between 2015 and 2023 was conducted. A comparative analysis was performed between patients undergoing primary versus revisional surgery., Results: A total of 263 patients were included in the study. Primary procedures were performed in 220 patients (83.7%) and revisional procedures in 43 patients (16.3%). BMS included one anastomosis gastric bypass (n = 183), sleeve gastrectomy (n = 63), and other procedures (n = 17). Mean BMI was 54.6 with no difference between groups. There was no difference in baseline characteristics except the revisional group was older (44.8 ± 9.6 versus 39 ± 13 years; p = 0.006), had higher rates of gastroesophageal reflux disease (21% vs 7.3%; p = 0.005), and fatty liver disease (74% vs 55%; p = 0.02). There was perioperative mortality in three cases (1.1%) with no significant difference between groups. Leak rates were higher, and length of stay (LOS) was longer in the revisional group (4.6% vs 0.45%; p = 0.018 and 2.9 vs 3.7; p = 0.006, respectively)., Conclusion: Revisional BMS in patients with a BMI ≥ 50 kg/m2 is associated with increased leak rates and LOS. Mortality rate is 1.1% and is insignificantly different between groups. Further prospective and large-scale studies are needed to clarify the optimal surgical approach to patients with extreme BMI including revisional surgery., (© 2024. The Author(s).)- Published
- 2024
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8. Primary versus Revisional One Anastomosis Gastric Bypass: Outcomes of Patients with at Least 8-Year Follow-Up.
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Abu-Abeid A, Bendayan A, Yuval JB, Eldar SM, Lahat G, and Lessing Y
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- Humans, Female, Male, Retrospective Studies, Follow-Up Studies, Adult, Treatment Outcome, Middle Aged, Diabetes Mellitus, Type 2 surgery, Anastomosis, Surgical methods, Anastomosis, Surgical adverse effects, Postoperative Complications epidemiology, Postoperative Complications etiology, Registries, Gastric Bypass methods, Gastric Bypass adverse effects, Reoperation statistics & numerical data, Weight Loss, Obesity, Morbid surgery
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Introduction: One anastomosis gastric bypass (OAGB) prevalence is increasing worldwide and shows good mid- to long-term results. Data on long-term outcomes of revisional OAGB (rOAGB) is limited. This study's objective was to evaluate the long-term outcomes of patients undergoing primary OAGB (pOAGB) and rOAGB., Methods: A retrospective analysis of a prospectively maintained patient registry at a single-tertiary center. Patients undergoing OAGB from January 2015 to May 2016 were included and grouped into pOAGB and rOAGB., Results: There were 424 patients, of which 363 underwent pOAGB, and 61 underwent rOAGB. Baseline characteristics were insignificantly different between groups except for the type 2 diabetes (T2D) rate which was higher in pOAGB (26% vs. 11.5%, p = 0.01). The mean follow-up time was 98.5 ± 3.9 months, and long-term follow-up data were available for 52.5% of patients. The mean total weight loss (TWL) was higher in the pOAGB group (31.3 ± 14 vs. 24.1 ± 17.6, p = 0.006); however, TWL was comparable when relating to the weight at primary surgery for rOAGB. The rate of T2D and hypertension resolution was 79% and 72.7% with no difference between groups. Thirteen patients (5.9%) underwent OAGB revision during follow-up, with no difference between groups. Two deaths occurred during follow-up, both non-related to OAGB., Conclusion: OAGB is effective as a primary and as a revisional procedure for severe obesity with good long-term results in terms of weight loss and resolution of associated diseases. In addition, the revisional surgery rates and chronic complications are acceptable. Further large prospective studies are required to clarify these data., (© 2024 The Author(s). Published by S. Karger AG, Basel.)
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- 2024
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9. Long Term Effects of Metabolic and Bariatric Surgery on Idiopathic Intracranial Hypertension.
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Abu-Abeid A, Bendayan A, Tome J, Lessing Y, Eldar SM, Keidar A, and Dayan D
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- Humans, Female, Adult, Retrospective Studies, Obesity surgery, Weight Loss, Gastrectomy methods, Treatment Outcome, Obesity, Morbid surgery, Pseudotumor Cerebri surgery, Bariatric Surgery methods, Gastric Bypass methods
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Background: Idiopathic Intracranial Hypertension (IIH) is a rare disorder, linked to severe obesity. The study aimed to evaluate long-term effects of metabolic and bariatric surgery (MBS) on IIH outcomes., Methods: Retrospective study of patients with IIH and severe obesity who underwent MBS. Data were retrieved from prospectively maintained databases of two bariatric surgeons., Results: Thirteen patients were included, of them 12 women. Median age was 36 (interquartile range;IQR 21,47) years and body mass index (BMI) was 40.4 (IQR 37.8,41.8) kg/m2. All patients had visual disturbances,12/13 had headaches, and 6/13 had tinnitus. The mean opening pressure on lumbar puncture was 45 cmH2O, and 11/13 patients had papilledema. Medications for IIH were consumed by 11/13 patients, and 2/13 patients had prior surgical intervention for IIH. MBS types included sleeve gastrectomy (n=7), adjustable gastric banding (n=2), roux-en-y gastric bypass (n=2), one anastomosis gastric bypass (n=1), duodenal switch (n=1). At a median follow-up of 10 years (IQR 8,13), the median BMI and total weight loss were 29.7 kg/m2 and 27%, respectively. Remission of symptoms was achieved in 9/13 patients., Conclusions: MBS results in significant and sustainable weight loss, with subsequent resolution or improvement of IIH. It may be considered as a preventive measure for IIH in patients with severe obesity., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2023
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10. The Impact of the COVID-19 Pandemic on an Israeli Acute Care Surgery Unit: Fewer Patients, More Disease.
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Maman Y, Lee Goldstein A, Neeman U, Lessing Y, Orbach L, Sirhan S, Falk E, and Lahat G
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- Humans, Aged, Pandemics prevention & control, Israel, SARS-CoV-2, Retrospective Studies, Communicable Disease Control, COVID-19
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Background: The COVID-19 pandemic has transformed and affected every aspect of health care. Like any catastrophic event, the stress on hospitals to maintain a certain level of function is immense. Acute surgical pathologies cannot be prevented or curtailed; therefore, it is important to understand patterns and outcomes during catastrophes in order to optimize care and organize the health care system., Methods: In a single urban tertiary care center, a retrospective study examined the first complete lockdown period of Israel during the COVID-19 pandemic. This was compared to the same time period the previous year., Results: During the pandemic, time to hospitalization was significantly decreased. There was also an overall reduction in surgical admissions yet with a higher percentage being hospitalized for further treatment (69.2% vs 23.5%). The patients admitted during this time had a higher APACHE-II score and Charlson comorbidity index score. During the pandemic, time to surgery was decreased, there were less laparoscopic procedures, and more RBC units were used per patient. There were no differences in overall complications, except when sub-analyzed for major complications (9.7% vs 6.3%). There was no significant difference in overall in-house mortality or morbidity. Length of hospitalization was significantly decreased in the elderly population during the pandemic., Conclusion: During the COVID-19 pandemic, despite a significantly less number of patients presenting to the hospital, there was a higher percentage of those admitted needing surgical intervention, and they were overall sicker than the previous year.
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- 2022
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11. Preoperative biopsy for suspected adenocarcinoma of the pancreatic head: yield and complications.
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Nevo N, Pencovich N, Lessing Y, Lasmanovich R, Barnes S, Lahat G, Nachmany I, and Klausner JM
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- Biopsy, Humans, Pancreaticoduodenectomy adverse effects, Retrospective Studies, Pancreatic Neoplasms, Adenocarcinoma diagnosis, Pancreatic Neoplasms diagnosis
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Background: Histologic confirmation before pancreaticoduodenectomy (PD) for suspected pancreatic cancer is often performed. We assessed the yield of preoperative biopsy in these patients considering the associated complications., Methods: We retrospectively evaluated 216 patients that underwent PD for suspected carcinoma (CA) between 2012 and 2018. Post procedure complications and delay in surgery were assessed, as well as the postoperative diagnosis in relation to preoperative parameters., Results: Preoperative biopsy was performed in 142 patients (65.7%). Pathologic findings suggestive of CA were found in 106 (74.6%), while benign histology was found in 23 (16.1%), and non-diagnostic findings in 12 (8.4%). Seventy-four patients (34.3%) were operated without a preoperative biopsy. The time from diagnosis to surgery was significantly prolonged in those that underwent biopsy compared to patients that were taken straight to surgery (40±14 versus 18±15 days, P<0.001), and 18 patients (12.6%) suffered from clinically significant post procedure complications. Patients with a preoperative biopsy suggestive of CA, and those that were operated without a preoperative histologic confirmation had comparable rates of CA as a final pathological diagnosis (95.2% and 94.5%, respectively). Nevertheless, in patients with a benign or a non-diagnostic biopsy, the rates of pathologic diagnosis of CA were 69.6% and 73.6% respectively. Elevated levels of CA19-9 and a positive preoperative biopsy were associated with a final pathology of CA., Conclusions: Preoperative histology is not uniformly required in patients with suspected pancreatic cancer. If preoperative biopsy is performed, benign histology does not rule out cancer but warrants additional evaluation prior to surgery.
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- 2022
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12. Roux-en-Y Gastric Bypass Versus One Anastomosis Gastric Bypass as a Preferred Revisional Bariatric Surgery After a Failed Silastic Ring Vertical Gastroplasty.
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Nevo N, Lessing Y, Abu-Abeid S, Goldstein AL, Hazzan D, Nachmany I, and Eldar SM
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- Dimethylpolysiloxanes, Humans, Reoperation, Retrospective Studies, Treatment Outcome, Bariatric Surgery, Gastric Bypass adverse effects, Gastroplasty adverse effects, Laparoscopy, Obesity, Morbid surgery
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Background: Over the years, the silastic ring vertical gastroplasty (SRVG) has shown poor long-term outcomes with both weight regain and complications. Therefore, most bariatric surgeons have been presented with the need to perform a successful and safe conversion procedure. Yet the preferred and recommended conversion surgery regarding weight loss, comorbidity improvement, and postoperative complications remains under debate., Objective: The aim of this study is to compare the outcomes of conversion from SRVG with either Roux-en-Y gastric bypass (RYGBP) or one anastomosis gastric bypass (OAGB)., Materials and Methods: A retrospective study was conducted from our bariatric surgery units' database. We reviewed the files of patients who underwent either a RYGBP or OAGB after a previous SRVG. Demographics, obesity-related comorbidities, BMI before and after the procedure, postoperative complications, and length of hospital stay were analyzed., Results: Between May 2008 and August 2018, fifty-four patients underwent conversion from a failed SRVG. Twenty-one patients underwent conversion to OAGB (39%), and thirty-three patients underwent conversion to RYGBP (61%). Major complications were reported in 9.5% of the OAGB group and 15.1% of the RYGBP group. At a mean follow-up of 28 months, the OAGB group achieved a 78.5% excess BMI loss compared with 57.6% in the RYGBP group (p = 0.137). One patient (4.7%) of the OGBP group and 5 (15.1%) of the RYGBP group needed reoperations due to complications (p = 0.224)., Conclusion: The OGBP is gaining popularity and evidence as an effective and safe procedure. Here we show the successful utilization of the OGBP, when compared with RYGBP, as a revisional procedure after SRVG.
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- 2021
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13. One Anastomosis Gastric Bypass as a Revisional Procedure After Failed Laparoscopic Adjustable Gastric Banding.
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Lessing Y, Nevo N, Pencovich N, Abu-Abeid S, Hazzan D, Nachmany I, and Eldar SM
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- Humans, Postoperative Complications epidemiology, Postoperative Complications surgery, Reoperation, Retrospective Studies, Treatment Outcome, Gastric Bypass adverse effects, Gastroplasty adverse effects, Laparoscopy, Obesity, Morbid surgery
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Background: Recent data demonstrates that laparoscopic adjustable gastric banding (LAGB) is found to be associated with high rates of weight loss failure and long-term complications. Therefore, the search for the optimal revisional bariatric procedure is ongoing., Objective: We aim to assess the safety and efficacy of converting a failed LAGB to laparoscopic one anastomosis gastric bypass (OAGB) as a revisional procedure., Setting: Large, metropolitan, tertiary, university hospital., Methods: Retrospective review of patients who underwent OAGB after LAGB.Demographics, comorbidities, BMI before and after the procedure, complications, and length of stay were documented., Results: Fifty-seven patients underwent OAGB after LAGB. For 41 patients, the band was removed, and an OAGB was performed in a single procedure (71.9%), and 96.5% of the cases were completed laparoscopically. Postoperative complications occurred in 9 patients (15.7%), including one mortality. Average BMI decreased from 42.8 ± 7.0 to 31.3 ± 5.2 kg/m
2 at least 1 year after surgery, representing a mean %EWL of 64.5%. There was no statistical difference in complication rates between the 1-stage and 2-stage approach., Conclusions: Conversion of a failed LAGB to OAGB is effective but carries higher complication rates. Randomized controlled studies comparing different procedures are necessary to further clarify the optimal revisional bariatric operation.- Published
- 2020
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14. Palliative bypass surgery for patients with advanced pancreatic adenocarcinoma: experience from a tertiary center.
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Pencovich N, Orbach L, Lessing Y, Elazar A, Barnes S, Berman P, Blachar A, Nachmany I, and Sagie B
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- Aged, Aged, 80 and over, Carcinoma, Pancreatic Ductal pathology, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms pathology, Postoperative Complications etiology, Postoperative Complications mortality, Retrospective Studies, Risk Factors, Survival Analysis, Tertiary Care Centers, Treatment Outcome, Carcinoma, Pancreatic Ductal surgery, Gastric Bypass adverse effects, Palliative Care, Pancreatic Neoplasms surgery
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Background: As advances in oncological treatment continue to prolong the survival of patients with non-resectable pancreatic ductal adenocarcinoma (PDAC), decision-making regarding palliative surgical bypass in patients with a heavy disease burden turns challenging. Here we present the results of a pancreatic surgery referral center., Methods: Patients that underwent palliative gastrojejunostomy and/or hepaticojejunostomy for advanced, non-resectable PDAC between January 2010 and November 2018 were retrospectively assessed. All patients were taken to a purely palliative surgery with no curative intent. The postoperative course as well as short and long-term outcomes was evaluated in relation to preoperative parameters., Results: Forty-two patients (19 females) underwent palliative bypass. Thirty-one underwent only gastrojejunostomy (22 laparoscopic) and 11 underwent both gastrojejunostomy and hepaticojejunostomy (all by an open approach). Although 34 patients (80.9%) were able to return temporarily to oral intake during the index admission, 15 (35.7%) suffered from a major postoperative complication. Seven patients (16.6%) died from surgery and another seven within the following month. Nine patients (21.4%) never left the hospital following the surgery. Mean length of hospital stay was 18 ± 17 days (range 3-88 days). Mean overall survival was 172.8 ± 179.2 and median survival was 94.5 days. Age, preoperative hypoalbuminemia, sarcopenia, and disseminated disease were associated with palliation failure, defined as inability to regain oral intake, leave the hospital, or early mortality., Conclusions: Although palliative gastrojejunostomy and hepaticojejunostomy may be beneficial for specific patients, severe postoperative morbidity and high mortality rates are still common. Patient selection remains crucial for achieving acceptable outcomes.
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- 2020
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15. Early reoperation following pancreaticoduodenectomy: impact on morbidity, mortality, and long-term survival.
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Lessing Y, Pencovich N, Nevo N, Lubezky N, Goykhman Y, Nakache R, Lahat G, Klausner JM, and Nachmany I
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- Aged, Anastomotic Leak surgery, Bile Duct Neoplasms surgery, Carcinoma, Pancreatic Ductal surgery, Cholangiocarcinoma surgery, Female, Humans, Male, Middle Aged, Morbidity, Pancreatic Neoplasms surgery, Pancreaticoduodenectomy mortality, Retrospective Studies, Pancreaticoduodenectomy adverse effects, Postoperative Complications surgery, Reoperation statistics & numerical data
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Background: Reoperation following PD is a surrogate marker for a complex post-operative course and may lead to devastating consequences. We evaluate the indications for early reoperation following PD and analyze its effect on short- and long-term outcome., Methods: Four hundred and thirty-three patients that underwent PD between August 2006 and June 2016 were retrospectively analyzed., Results: Forty-eight patients (11%; ROp group) underwent 60 reoperations within 60 days from PD. Forty-two patients underwent 1 reoperation, and 6 had up to 6 reoperations. The average time to first reoperation was 10.1 ± 13.4 days. The most common indications were anastomotic leaks (22 operations in 18 patients; 37.5% of ROp), followed by post-pancreatectomy hemorrhage (PPH) (14 reoperations in 12 patients; 25%), and wound complications in 10 (20.8%). Patients with cholangiocarcinoma had the highest reoperation rate (25%) followed by ductal adenocarcinoma (12.3%). Reoperation was associated with increased length of hospital stay and a high post-operative mortality of 18.7%, compared to 2.6% for the non-reoperated group. For those who survived the post-operative period, the overall and disease-free survival were not affected by reoperation., Conclusions: Early reoperations following PD carries a dramatically increased mortality rate, but has no impact on long-term survival.
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- 2019
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16. Major liver resection in pregnancy: three cases with different etiologies and review of the literature.
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Pencovich N, Younis M, Lessing Y, Zac L, Lessing JB, Yogev Y, Kupferminc MJ, and Nachmany I
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- Adult, Bile Duct Neoplasms pathology, Bile Ducts, Intrahepatic surgery, Cholangiocarcinoma pathology, Female, Hemangioma pathology, Hepatectomy adverse effects, Hepatectomy methods, Humans, Kasabach-Merritt Syndrome pathology, Kasabach-Merritt Syndrome surgery, Liver Neoplasms pathology, Pregnancy, Pregnancy Complications, Neoplastic pathology, Pregnancy Outcome, Tumor Burden, Bile Duct Neoplasms surgery, Cholangiocarcinoma surgery, Echinococcosis, Hepatic surgery, Hemangioma surgery, Liver Neoplasms surgery, Pregnancy Complications, Neoplastic surgery, Pregnancy Complications, Parasitic surgery
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Background: Major liver resection during pregnancy is extremely rare. When required, the associated physiologic and anatomic changes pose specific challenges and greater risk for both mother and fetus Materials and methods: Three cases of major liver resection during pregnancy due to different etiologies are presented. The relevant literature is reviewed and discussed., Results: We present three cases of major liver resection due to giant liver hemangioma with Kasabach-Merrit syndrome, giant hydatid cyst, and intrahepatic cholangiocarcinoma, at gestational week (GW) 17, 19, and 30, respectively. All patients had an uneventful postoperative course, continued the pregnancy and gave birth at GW 38., Conclusion: Major liver resection can be performed safely during pregnancy. A multidisciplinary team of surgeons, anesthesiologists and gynecologists, in a highly experienced tertiary hepatobiliary center, should be involved.
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- 2019
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17. Sleeve Gastrectomy in the Elderly.
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Nevo N, Eldar SM, Lessing Y, Sabo E, Nachmany I, and Hazzan D
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- Age Factors, Aged, Aged, 80 and over, Body Mass Index, Case-Control Studies, Comorbidity, Feasibility Studies, Female, Humans, Laparoscopy adverse effects, Laparoscopy methods, Laparoscopy statistics & numerical data, Length of Stay statistics & numerical data, Male, Obesity, Morbid epidemiology, Postoperative Complications epidemiology, Reoperation statistics & numerical data, Retrospective Studies, Weight Loss, Aging physiology, Gastrectomy adverse effects, Gastrectomy methods, Gastrectomy statistics & numerical data, Obesity, Morbid surgery
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Background: Even though risks are higher and long-term results may be less favorable, the elderly obese can still benefit from bariatric surgery. Whether the higher surgical risk is worth the benefits is yet to be determined., Materials and Methods: We reviewed our database and identified all patients aged 65 or older who underwent sleeve gastrectomy between May 2010 and November 2015. We documented patient demographics, obesity-related comorbidities, body mass index (BMI) before and after the procedure, percent excess weight loss, comorbidity improvement or resolution, length of follow-up, postoperative complications, re-operations, and length of hospital stay. We compared our study group to a control group of sleeve gastrectomy patients under the age of 65., Results: Sixty-six patients (mean age 67.6 ± 2.6 years) underwent laparoscopic sleeve gastrectomy. Patients achieved an average of 53.5% excess BMI loss (EBMIL) after 21 months of follow-up. EBMIL was inferior to that achieved by the control group (EBMIL 77.3%, p < 0.0001). Elderly patients showed significant improvement or resolution in all obesity-related comorbidities. Complication and re-operation rates were similar between the 2 groups., Conclusion: In an elderly population, laparoscopic sleeve gastrectomy is safe and effective, yet weight loss outcomes are more modest when compared to a younger surgical population. Carefully selected elderly patients can benefit from bariatric surgery., (© 2019 The Author(s) Published by S. Karger AG, Basel.)
- Published
- 2019
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18. Comparison between laparoscopic and open Hartmann's reversal: results of a decade-long multicenter retrospective study.
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Horesh N, Lessing Y, Rudnicki Y, Kent I, Kammar H, Ben-Yaacov A, Dreznik Y, Avital S, Mavor E, Wasserberg N, Kashtan H, Klausner J, Gutman M, Zmora O, and Tulchinsky H
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- Anastomosis, Surgical methods, Colon surgery, Female, Humans, Israel, Male, Middle Aged, Outcome and Process Assessment, Health Care, Retrospective Studies, Colectomy adverse effects, Colectomy methods, Colostomy adverse effects, Colostomy methods, Intestinal Obstruction surgery, Intestinal Perforation surgery, Laparoscopy adverse effects, Laparoscopy methods, Laparoscopy statistics & numerical data, Postoperative Complications epidemiology, Postoperative Complications etiology, Postoperative Complications prevention & control
- Abstract
Background: Hartmann's reversal is a challenging surgical procedure with significant postoperative morbidity rates. Various surgical methods have been suggested to lower the risk of postoperative complications. In this study, we aimed to compare the postoperative results between open and laparoscopic techniques for Hartmann's reversal., Methods: A retrospective study of all patients who underwent Hartmann's reversal in five centers in central Israel between January 2004 and June 2015 was conducted. Medical charts were reviewed, analyzing preoperative and operative parameters and short-term postoperative outcomes., Results: 260 patients were included in the study. 76 patients were operated laparoscopically with a conversion rate of 26.3% (20 patients). No differences were found between patients operated laparoscopically and those operated in an open technique regarding gender (p = 0.785), age (61.34 vs. 62.64, p = 0.521), body mass index (26.6 vs. 26.2, p = 0.948), Charlson index score (1.79 vs. 1.95, p = 0.667), and cause for Hartmann's procedure (neoplastic vs. non-neoplastic, p = 0.644). No differences were seen in average time from the Hartmann's procedure to reversal (204.89 vs. 213.60 days, p = 0.688) and in overall complication rate (46.4 vs. 46.5%, p = 1). The Clavien-Dindo score for distinguishing between minor (0-2 score, p = 1) and major complications (3-5 score, p = 0.675) failed to demonstrate an advantage to laparoscopy, as well as to average length of stay (10.91 days in the laparoscopic group vs. 11.72 days in the open group, p = 0.529). An analysis based on the intention-to-treat with laparoscopy, including converted cases in the laparoscopic group, showed similar results, including overall complication rate (48.6 vs. 45.6%, p = 0.68) and Clavien-Dindo score in both minor (p = 0.24) and major complications (p = 0.44). Length of stay (10.92 vs. 11.81 days, p = 0.45) was also similar between the two groups., Conclusion: In this series, a laparoscopic approach to Hartmann's reversal did not offer any short-term advantage when compared to an open surgical approach.
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- 2018
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19. Diabetes resolution after one anastomosis gastric bypass.
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Abu-Abeid A, Lessing Y, Pencovich N, Dayan D, Klausner JM, and Abu-Abeid S
- Subjects
- Adult, Anastomosis, Surgical methods, Body Mass Index, Cohort Studies, Comorbidity, Diabetes Mellitus, Type 2 diagnosis, Diabetes Mellitus, Type 2 surgery, Female, Follow-Up Studies, Hospitals, University, Humans, Israel, Laparoscopy methods, Male, Middle Aged, Obesity, Morbid diagnosis, Postoperative Care methods, Recovery of Function physiology, Retrospective Studies, Treatment Outcome, Weight Loss physiology, Blood Glucose analysis, Diabetes Mellitus, Type 2 epidemiology, Gastric Bypass methods, Obesity, Morbid epidemiology, Obesity, Morbid surgery
- Abstract
Background: Diabetes and other obesity-related diseases are a worldwide pandemic that transcends geographic borders as well as socioeconomic levels. Currently, it is well known that medical treatment alone is insufficient to ensure adequate and sustainable weight loss and co-morbidity resolution. It has been well proven that bariatric surgery can produce almost immediate resolution of diabetes and other co-morbidities as well as long-term weight loss., Objectives: Here, we present our experience with the one anastomosis gastric bypass (OAGB) in terms of weight loss and diabetes resolution with 1 year of follow-up., Setting: Large, metropolitan, tertiary, university hospital., Methods: A retrospective analysis of all patients who underwent OAGB between March 2015 and March 2016 was performed. Patient demographic characteristics, co-morbidities, operative and postoperative data, as well as first year outcomes were collected and analyzed., Results: There were 407 patients who underwent OAGB (254 females, average age 41.8 ± 12.05 yr, body mass index = 41.7 ± 5.77 kg/m
2 ). Of patients, 102 (25.1%) had diabetes with average glycosylated hemoglobin of 8.64 ± 1.94 g%, 93 (22.8%) had hypertension, 123 (28.8%) had hyperlipidemia, and 35 patients (8.6%) had obstructive sleep apnea. The average length of hospital stay was 2.2 ± .84 days (range, 2-10 d). The average excess weight loss 1 year after surgery was 88.9 ± 27.3. After 1 year, follow-up data were available for more than 85% of the study's general population. Of 102 diabetic patients, only 8 (7.8%) were still considered diabetic and taking antidiabetic medication, with an average glycosylated hemoglobin of 5.4 ± 0.6., Conclusions: OAGB may be performed safely and with promising efficacy as both a primary and a revisional bariatric surgery, and it offers excellent resolution of diabetes., (Copyright © 2018 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.)- Published
- 2018
- Full Text
- View/download PDF
20. Considerations for Hartmann's reversal and Hartmann's reversal outcomes-a multicenter study.
- Author
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Horesh N, Lessing Y, Rudnicki Y, Kent I, Kammar H, Ben-Yaacov A, Dreznik Y, Tulchinsky H, Avital S, Mavor E, Wasserberg N, Kashtan H, Klausner JM, Gutman M, and Zmora O
- Subjects
- Adult, Aged, Cohort Studies, Colectomy adverse effects, Colectomy methods, Colon, Sigmoid pathology, Colon, Sigmoid physiopathology, Colostomy adverse effects, Colostomy methods, Female, Humans, Israel, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Anastomosis, Surgical adverse effects, Anastomosis, Surgical methods, Colon, Sigmoid surgery, Colonic Diseases surgery, Postoperative Complications diagnosis, Postoperative Complications etiology, Postoperative Complications surgery, Plastic Surgery Procedures adverse effects, Plastic Surgery Procedures methods, Plastic Surgery Procedures statistics & numerical data, Rectum surgery, Reoperation adverse effects, Reoperation methods, Reoperation statistics & numerical data
- Abstract
Purpose: Hartmann's procedure is commonly practiced in emergent cases with the restoration of bowel continuity planned at a second stage. This study assessed the rate of restorations following Hartmann's procedure and evaluated factors affecting decision-making., Methods: Data on patient demographics, comorbidities, causes for Hartmann's procedure, reversal rate, and complications were collected in a multicenter retrospective cohort study of patients who underwent Hartmann's procedure in five medical centers., Results: Six hundred forty patients underwent Hartmann's procedure for diverticular disease (36.1%), obstructing malignancy (31.8%), benign obstruction (5%), and other reasons (23.1%). Overall, 260 (40.6%) patients underwent subsequent restoration of bowel continuity. One hundred twenty-one (46.5%) patients had post-reversal complications, with an average Clavien-Dindo score of 1.4 and a mortality rate of 0.77%. Decision to avoid reversal was mostly related to comorbidities (49.7%) and metastatic disease (21.6%). Factors associated with the decision to restore bowel continuity included male gender (P = 0.02), patient age (62.3 years in Hartmann's reversal patients vs 73.5 years in non-reversal patients; P < 0.0001), number of comorbidities (1.1 vs 1.58; P < 0.001), average Charlson score (1.93 vs 3.44; P < 0.001), and a neoplastic etiology (P < 0.0001). A sub-analysis excluding all patients who died in the 30 days following Hartmann's procedure showed similar factors associated with ostomy closure., Conclusion: Many patients do not have restoration of bowel continuity after undergoing Hartmann's procedure. Hartmann's reversal is associated with a significant postoperative morbidity. Surgeons and patients should be aware of the possibility that the colostomy might become permanent.
- Published
- 2017
- Full Text
- View/download PDF
21. Laparoscopic sleeve gastrectomy for diabetics - 5-year outcomes.
- Author
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Lessing Y, Pencovich N, Lahat G, Klausner JM, Abu-Abeid S, and Meron Eldar S
- Subjects
- Adult, Bariatric Surgery statistics & numerical data, Blood Glucose metabolism, Body Mass Index, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 complications, Female, Gastrectomy statistics & numerical data, Glycated Hemoglobin metabolism, Humans, Hyperlipidemias complications, Hypertension complications, Laparoscopy statistics & numerical data, Length of Stay, Male, Middle Aged, Myocardial Ischemia, Obesity, Morbid blood, Obesity, Morbid complications, Reoperation methods, Reoperation statistics & numerical data, Retrospective Studies, Treatment Outcome, Weight Loss physiology, Bariatric Surgery methods, Diabetes Mellitus, Type 2 surgery, Gastrectomy methods, Laparoscopy methods, Obesity, Morbid surgery
- Abstract
Objective: Although the laparoscopic sleeve gastrectomy (SG) is increasingly performed for morbid obesity, gastric bypass is still considered by many to be the gold standard procedure for obese diabetic patients. The aim of this study was to assess the long-term results of SG in morbidly obese patients with type 2 diabetes., Methods: Diabetic patients who underwent SG at a single center between 2009 and 2011 were included. Outcomes assessed included postoperative complications, weight loss, and resolution or improvement in co-morbidities with an emphasis on diabetes, including glycated hemoglobin (HbA1C) and medication status., Results: Fifty-one diabetic patients underwent SG, 35 females and 16 males, with a collective mean age of 49 years and a mean body mass index of 43.2 kg/m
2 . On average, patients had had diabetes for 5.4 ± 7.3 years before surgery. Mean HbA1C and fasting glucose levels were 7.9 ± 1.6% and 166.9 ± 63 mg/dL, respectively. Eleven patients (22%) were insulin dependent at the time of surgery. Average body mass index at a mean follow-up of 5 years after surgery was 34.4 ± 5.8 kg/m2 , with an average HbA1C of 6.6 ± 1% and an average fasting glucose of 123 ± 60 mg/dL. Only 3 patients remained insulin dependent., Conclusion: SG offers retainable weight loss results, accompanied by longstanding resolution or improvement of diabetes. Prospective, randomized controlled studies are warranted to better compare long-term outcomes between SG and gastric bypass., (Copyright © 2017 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.)- Published
- 2017
- Full Text
- View/download PDF
22. One-Anastomosis Gastric Bypass: First 407 Patients in 1 year.
- Author
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Lessing Y, Pencovich N, Khatib M, Meron-Eldar S, Koriansky J, and Abu-Abeid S
- Subjects
- Adolescent, Adult, Aged, Comorbidity, Female, Gastrectomy adverse effects, Gastrectomy methods, Gastric Bypass adverse effects, Humans, Laparoscopy adverse effects, Laparoscopy methods, Length of Stay, Male, Middle Aged, Obesity, Morbid epidemiology, Operative Time, Reoperation adverse effects, Reoperation statistics & numerical data, Retrospective Studies, Treatment Outcome, Weight Loss, Young Adult, Gastric Bypass methods, Obesity, Morbid surgery
- Abstract
Background: One-anastomosis gastric bypass (OAGB) is a promising laparoscopic procedure with various benefits including shorter operating times and less operative complications. That said, it is yet to gain widespread acceptance. Here, we describe our first-year experience with OAGB in our department, in particular the safety and efficacy of this procedure., Methods: This study is a retrospective analysis of all patients who underwent OAGB between March 2015 and March 2016 by our bariatric surgery unit. Patient demographics, comorbidities, operative and postoperative data were collected and analyzed as well as outcomes during the first year., Results: Four hundred and seven patients underwent OAGB (254 females, average age 41.8 ± 12.05, BMI = 41.7 ± 5.77 kg/m
2 ). Ninety-eight patients (24%) had prior bariatric surgery. Ninety-four patients (23%) had diabetes, 93 patients (22.8%) had hypertension, 123 (28.8%) had hyperlipidemia, and 35 patients (8.6%) suffered from obstructive sleep apnea. Eight patients (1.96%) had early minor complications (Clavien-Dindo 1-3a), and 10 patients (2.45%) suffered early major complications (Clavien-Dindo ≥3b). The average length of hospital stay was 2.2 ± 0.84 days (range 2-10 days). Twenty patients (4.8%) were readmitted, and 10 patients underwent reoperation. Patients who had had previous bariatric surgery had higher rates of complications, a prolonged hospital admission, higher rates of readmission, and early reoperations. The average excess weight loss (%EWL) 1 year following surgery was 88.9 ± 27.3 and 72.8 ± 43.5% in patients that underwent primary and revision OAGB, respectively., Conclusions: OAGB is both safe and effective as a primary as well as a revision bariatric surgery.- Published
- 2017
- Full Text
- View/download PDF
23. Surgery after neoadjuvant chemotherapy for locally advanced extrapulmonary poorly differentiated neuroendocrine cancer.
- Author
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Lessing Y, Ben-Haim M, Lahat G, Nackache R, Klausner JM, Shmueli E, and Lubezky N
- Subjects
- Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Neuroendocrine diagnostic imaging, Carcinoma, Neuroendocrine mortality, Disease-Free Survival, Duodenal Neoplasms diagnostic imaging, Duodenal Neoplasms mortality, Duodenal Neoplasms pathology, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging methods, Male, Middle Aged, Neoplasm Invasiveness pathology, Neoplasm Recurrence, Local pathology, Neoplasm Recurrence, Local therapy, Neoplasm Staging, Pancreatic Neoplasms diagnostic imaging, Pancreatic Neoplasms mortality, Pancreatic Neoplasms pathology, Pancreatic Neoplasms therapy, Risk Assessment, Sampling Studies, Sigmoid Neoplasms diagnostic imaging, Sigmoid Neoplasms mortality, Sigmoid Neoplasms pathology, Survival Rate, Tomography, X-Ray Computed methods, Treatment Outcome, Carcinoma, Neuroendocrine pathology, Carcinoma, Neuroendocrine therapy, Duodenal Neoplasms therapy, Neoadjuvant Therapy methods, Pancreaticoduodenectomy methods, Sigmoid Neoplasms therapy
- Published
- 2011
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