3,541 results on '"Lessard P"'
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2. Adaptive Backtracking For Faster Optimization
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Cavalcanti, Joao V., Lessard, Laurent, and Wilson, Ashia C.
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Mathematics - Optimization and Control ,Computer Science - Machine Learning - Abstract
Backtracking line search is foundational in numerical optimization. The basic idea is to adjust the step size of an algorithm by a constant factor until some chosen criterion (e.g. Armijo, Goldstein, Descent Lemma) is satisfied. We propose a new way for adjusting step sizes, replacing the constant factor used in regular backtracking with one that takes into account the degree to which the chosen criterion is violated, without additional computational burden. For convex problems, we prove adaptive backtracking requires fewer adjustments to produce a feasible step size than regular backtracking does for two popular line search criteria: the Armijo condition and the descent lemma. For nonconvex smooth problems, we additionally prove adaptive backtracking enjoys the same guarantees of regular backtracking. Finally, we perform a variety of experiments on over fifteen real world datasets, all of which confirm that adaptive backtracking often leads to significantly faster optimization.
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- 2024
3. From the Lagrange Triangle to the Figure Eight Choreography: Proof of Marchal's Conjecture
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Calleja, Renato, García-Azpeitia, Carlos, Hénot, Olivier, Lessard, Jean-Philippe, and James, Jason D. Mireles
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Mathematics - Dynamical Systems - Abstract
For the three body problem with equal masses, we prove that the most symmetric continuation class of Lagrange's equilateral triangle solution, also referred to as the $P_{12}$ family of Marchal, contains the remarkable figure eight choreography discovered by Moore in 1993, and proven to exist by Chenciner and Montgomery in 2000. This settles a conjecture of Marchal which dates back to the 1999 conference on Celestial Mechanics in Evanston Illinois, celebrating Donald Saari's 60th birthday.
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- 2024
4. A Vision to Enhance Trust Requirements for Peer Support Systems by Revisiting Trust Theories
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Gheidar, Yasaman, Lessard, Lysanne, and Yao, Yao
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Computer Science - Computers and Society - Abstract
This vision paper focuses on the mental health crisis impacting healthcare workers (HCWs), which exacerbated by the COVID-19 pandemic, leads to increased stress and psychological issues like burnout. Peer Support Programs (PSP) are a recognized intervention for mitigating these issues. These programs are increasingly being delivered virtually through Peer Support Systems (PSS) for increased convenience and accessibility. However, HCWs perception of these systems results in fear of information sharing, perceived lack of safety, and low participation rate, which challenges these systems ability to achieve their goals. In line with the rich body of research on the requirements and properties of trustworthy systems, we posit that increasing HCWs trust in PSS could address these challenges. However, extant research focuses on objectively defined trustworthiness rather than perceptual trust because trustworthy requirements are viewed as more controllable and easier to operationalize. This study proposes a novel approach to elicit perceptual trust requirements by proposing a trust framework anchored in recognized trust theories from different disciplines that unpacks trust into its recognized types and their antecedents. This approach allows the identification of trust requirements beyond those already proposed for trustworthy systems, providing a strong foundation for improving the effectiveness of PSS for HCWs. Keywords: Trust Requirements, Requirements elicitation, Peer support systems, Healthcare workers, Comment: Accepted for publication at the RE@Next! track of RE 2024
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- 2024
5. School-Supervised Asthma Therapy Is Associated with Improved Long-Term Asthma Outcomes for Underrepresented Minority Children
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Holly N. Shillan, Janki P. Luther, Grace W. Ryan, Shushmita Hoque, Michelle A. Spano, Darleen M. Lessard, Lynn B. Gerald, Lori Pbert, Wanda Phipatanakul, Robert J. Goldberg, and Michelle K. Trivedi
- Abstract
Asthma morbidity disproportionately impacts children from low-income and racial/ethnic minority communities. School-supervised asthma therapy improves asthma outcomes for up to 15 months for underrepresented minority children, but little is known about whether these benefits are sustained over time. We examined the frequency of emergency department (ED) visits and hospital admissions for 83 children enrolled in Asthma Link, a school nurse-supervised asthma therapy program serving predominantly underrepresented minority children. We compared outcomes between the year preceding enrollment and years one-four post-enrollment. Compared with the year prior to enrollment, asthma-related ED visits decreased by 67.9% at one year, 59.5% at two years, 70.2% at three years, and 50% at four years post-enrollment (all p-values< 0.005). There were also significant declines in mean numbers of total ED visits, asthma-related hospital admissions, and total hospital admissions. Our results indicate that school nurse-supervised asthma therapy could potentially mitigate racial/ethnic and socioeconomic inequities in childhood asthma.
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- 2024
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6. Physiological Adaptations to Progressive Endurance Exercise Training in Adult and Aged Rats: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)
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Schenk, Simon, Sagendorf, Tyler J, Many, Gina M, Lira, Ana K, de Sousa, Luis GO, Bae, Dam, Cicha, Michael, Kramer, Kyle S, Muehlbauer, Michael, Hevener, Andrea L, Rector, R Scott, Thyfault, John P, Williams, John P, Goodyear, Laurie J, Esser, Karyn A, Newgard, Christopher B, Bodine, Sue C, Adkins, Joshua N, Albertson, Brent G, Amar, David, Amper, Mary Anne S, Ashley, Euan, Bamman, Marcas M, Barnes, Jerry, Bergman, Bryan C, Bessesen, Daniel H, Buford, Thomas W, Burant, Charles F, Cutter, Gary R, De Sousa, Luis Gustavo Oliveria, Fernández, Facundo M, Gaul, David A, Ge, Yongchao, Goodpaster, Bret H, Guevara, Kristy, Hirshman, Michael F, Huffman, Kim M, Jackson, Bailey E, Jankowski, Catherine M, Jimenez-Morales, David, Kohrt, Wendy M, Kraus, William E, Lessard, Sarah J, Lester, Bridget, Lindholm, Malene E, Many, Gina, Marjanovic, Nada, Marshall, Andrea G, Melanson, Edward L, Miller, Michael E, Moreau, Kerrie L, Nair, Venugopalan D, Ortlund, Eric A, Qian, Wei-Jun, Rasmussen, Blake B, Richards, Collyn Z-T, Rushing, Scott, Sanford, James A, Schauer, Irene E, Schwartz, Robert S, Sealfon, Stuart C, Seenarine, Nitish, Sparks, Lauren M, Stowe, Cynthia L, Talton, Jennifer W, Teng, Christopher, Tesfa, Nathan D, Thalacker-Mercer, Anna, Trappe, Scott, Trappe, Todd A, Vasoya, Mital, Wheeler, Matthew T, Walkup, Michael P, Yan, Zhen, and Zhen, Jimmy
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Biomedical and Clinical Sciences ,Clinical Sciences ,Physical Activity ,Cardiovascular ,Prevention ,Behavioral and Social Science ,Animals ,Male ,Rats ,Inbred F344 ,Female ,Physical Conditioning ,Animal ,Adaptation ,Physiological ,Rats ,Aging ,Physical Endurance ,Muscle ,Skeletal ,Endurance Training ,training ,treadmill ,maximal oxygen uptake ,body composition ,citrate synthase ,skeletal muscle ,biorepository ,aging ,MoTrPAC Study Group ,Medical physiology - Abstract
While regular physical activity is a cornerstone of health, wellness, and vitality, the impact of endurance exercise training on molecular signaling within and across tissues remains to be delineated. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to characterize molecular networks underlying the adaptive response to exercise. Here, we describe the endurance exercise training studies undertaken by the Preclinical Animal Sites Studies component of MoTrPAC, in which we sought to develop and implement a standardized endurance exercise protocol in a large cohort of rats. To this end, Adult (6-mo) and Aged (18-mo) female (n = 151) and male (n = 143) Fischer 344 rats were subjected to progressive treadmill training (5 d/wk, ∼70%-75% VO2max) for 1, 2, 4, or 8 wk; sedentary rats were studied as the control group. A total of 18 solid tissues, as well as blood, plasma, and feces, were collected to establish a publicly accessible biorepository and for extensive omics-based analyses by MoTrPAC. Treadmill training was highly effective, with robust improvements in skeletal muscle citrate synthase activity in as little as 1-2 wk and improvements in maximum run speed and maximal oxygen uptake by 4-8 wk. For body mass and composition, notable age- and sex-dependent responses were observed. This work in mature, treadmill-trained rats represents the most comprehensive and publicly accessible tissue biorepository, to date, and provides an unprecedented resource for studying temporal-, sex-, and age-specific responses to endurance exercise training in a preclinical rat model.
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- 2024
7. Periodic localized traveling waves in the two-dimensional suspension bridge equation
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van der Aalst, Lindsey, Berg, Jan Bouwe van den, and Lessard, Jean-Philippe
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Mathematics - Analysis of PDEs ,Mathematics - Dynamical Systems - Abstract
In the dynamics generated by the suspension bridge equation, traveling waves are an essential feature. The existing literature focuses primarily on the idealized one-dimensional case, while traveling structures in two spatial dimensions have only been studied via numerical simulations. We use computer-assisted proof methods based on a Newton-Kantorovich type argument to find and prove periodic localized traveling waves in two dimensions. The main obstacle is the exponential nonlinearity in combination with the resulting large amplitude of the localized waves. Our analysis hinges on establishing computable bounds to control the aliasing error in the computed Fourier coefficients. This leads to existence proofs of different traveling wave solutions, accompanied by small, explicit, rigorous bounds on the deficiency of numerical approximations. This approach is directly extendable to other wave equation models and elliptic partial differential equations with analytic nonlinearities, in two as well as in higher dimensions., Comment: Added a reference
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- 2024
8. Cusp bifurcations: numerical detection via two-parameter continuation and computer-assisted proofs of existence
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Lessard, Jean-Philippe and Pugliese, Alessandro
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Mathematics - Dynamical Systems ,65P30, 65G40, 34C23, 37M20, 37G99 - Abstract
This paper introduces a novel computer-assisted method for detecting and constructively proving the existence of cusp bifurcations in differential equations. The approach begins with a two-parameter continuation along which a tool based on the theory of Poincar\'e index is employed to identify the presence of a cusp bifurcation. Using the approximate cusp location, Newton's method is then applied to a given augmented system (the cusp map), yielding a more precise numerical approximation of the cusp. Through a successful application of a Newton-Kantorovich type theorem, we establish the existence of a non-degenerate zero of the cusp map in the vicinity of the numerical approximation. Employing a Gershgorin circles argument, we then prove that exactly one eigenvalue of the Jacobian matrix at the cusp candidate has zero real part, thus rigorously confirming the presence of a cusp bifurcation. Finally, by incorporating explicit control over the cusp's location, a rigorous enclosure for the normal form coefficient is obtained, providing the explicit dynamics on the center manifold at the cusp. We show the effectiveness of this method by applying it to four distinct models.
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- 2024
9. Stationary non-radial localized patterns in the planar Swift-Hohenberg PDE: constructive proofs of existence
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Cadiot, Matthieu, Lessard, Jean-Philippe, and Nave, Jean-Christophe
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Mathematics - Analysis of PDEs ,Mathematics - Dynamical Systems - Abstract
In this paper, we present a methodology for establishing constructive proofs of existence of smooth, stationary, non-radial localized patterns in the planar Swift-Hohenberg equation. Specifically, given an approximate solution $u_0$, we construct an approximate inverse for the linearization around $u_0$, enabling the development of a Newton-Kantorovich approach. Consequently, we derive a sufficient condition for the existence of a unique localized pattern in the vicinity of $u_0$. The verification of this condition is facilitated through a combination of analytic techniques and rigorous numerical computations. Moreover, an additional condition is derived, establishing that the localized pattern serves as the limit of a family of periodic solutions (in space) as the period tends to infinity. The integration of analytical tools and meticulous numerical analysis ensures a comprehensive validation of this condition. To illustrate the efficacy of the proposed methodology, we present computer-assisted proofs for the existence of three distinct unbounded branches of periodic solutions in the planar Swift-Hohenberg equation, all converging towards a localized planar pattern, whose existence is also proven constructively. All computer-assisted proofs, including the requisite codes, are accessible on GitHub at \cite{julia_cadiot}.
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- 2024
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10. Controlled patterning of crystalline domains by frontal polymerization
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Paul, Justine E., Gao, Yuan, Go, Yoo Kyung, Rodriguez Koett, Luis E., Sharma, Anisha, Chen, Manxin, Lessard, Jacob J., Topkaya, Tolga, Leal, Cecilia, Moore, Jeffrey S., Geubelle, Philippe H., and Sottos, Nancy R.
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- 2024
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11. Position: Categorical Deep Learning is an Algebraic Theory of All Architectures
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Gavranović, Bruno, Lessard, Paul, Dudzik, Andrew, von Glehn, Tamara, Araújo, João G. M., and Veličković, Petar
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Mathematics - Category Theory ,Mathematics - Rings and Algebras ,Statistics - Machine Learning - Abstract
We present our position on the elusive quest for a general-purpose framework for specifying and studying deep learning architectures. Our opinion is that the key attempts made so far lack a coherent bridge between specifying constraints which models must satisfy and specifying their implementations. Focusing on building a such a bridge, we propose to apply category theory -- precisely, the universal algebra of monads valued in a 2-category of parametric maps -- as a single theory elegantly subsuming both of these flavours of neural network design. To defend our position, we show how this theory recovers constraints induced by geometric deep learning, as well as implementations of many architectures drawn from the diverse landscape of neural networks, such as RNNs. We also illustrate how the theory naturally encodes many standard constructs in computer science and automata theory., Comment: To appear in ICML 2024. Comments welcome. More info at categoricaldeeplearning.com
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- 2024
12. A rigorous integrator and global existence for higher-dimensional semilinear parabolic PDEs via semigroup theory
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Duchesne, Gabriel William, Lessard, Jean-Philippe, and Takayasu, Akitoshi
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Mathematics - Analysis of PDEs ,Mathematics - Dynamical Systems ,Mathematics - Numerical Analysis ,65M15, 65G40, 65M70, 35A01, 35B40, 35K91 - Abstract
In this paper, we introduce a general constructive method to compute solutions of initial value problems of semilinear parabolic partial differential equations via semigroup theory and computer-assisted proofs. Once a numerical candidate for the solution is obtained via a finite dimensional projection, Chebyshev series expansions are used to solve the linearized equations about the approximation from which a solution map operator is constructed. Using the solution operator (which exists from semigroup theory), we define an infinite dimensional contraction operator whose unique fixed point together with its rigorous bounds provide the local inclusion of the solution. Applying this technique for multiple time steps leads to constructive proofs of existence of solutions over long time intervals. As applications, we study the 3D/2D Swift-Hohenberg, where we combine our method with explicit constructions of trapping regions to prove global existence of solutions of initial value problems converging asymptotically to nontrivial equilibria. A second application consists of the 2D Ohta-Kawasaki equation, providing a framework for handling derivatives in nonlinear terms.
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- 2024
13. Temporal dynamics of the multi-omic response to endurance exercise training
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Bae, Dam, Dasari, Surendra, Dennis, Courtney, Evans, Charles R, Gaul, David A, Ilkayeva, Olga, Ivanova, Anna A, Kachman, Maureen T, Keshishian, Hasmik, Lanza, Ian R, Lira, Ana C, Muehlbauer, Michael J, Nair, Venugopalan D, Piehowski, Paul D, Rooney, Jessica L, Smith, Kevin S, Stowe, Cynthia L, Zhao, Bingqing, Clark, Natalie M, Jimenez-Morales, David, Lindholm, Malene E, Many, Gina M, Sanford, James A, Smith, Gregory R, Vetr, Nikolai G, Zhang, Tiantian, Almagro Armenteros, Jose J, Avila-Pacheco, Julian, Bararpour, Nasim, Ge, Yongchao, Hou, Zhenxin, Marwaha, Shruti, Presby, David M, Natarajan Raja, Archana, Savage, Evan M, Steep, Alec, Sun, Yifei, Wu, Si, Zhen, Jimmy, Bodine, Sue C, Esser, Karyn A, Goodyear, Laurie J, Schenk, Simon, Montgomery, Stephen B, Fernández, Facundo M, Sealfon, Stuart C, Snyder, Michael P, Adkins, Joshua N, Ashley, Euan, Burant, Charles F, Carr, Steven A, Clish, Clary B, Cutter, Gary, Gerszten, Robert E, Kraus, William E, Li, Jun Z, Miller, Michael E, Nair, K Sreekumaran, Newgard, Christopher, Ortlund, Eric A, Qian, Wei-Jun, Tracy, Russell, Walsh, Martin J, Wheeler, Matthew T, Dalton, Karen P, Hastie, Trevor, Hershman, Steven G, Samdarshi, Mihir, Teng, Christopher, Tibshirani, Rob, Cornell, Elaine, Gagne, Nicole, May, Sandy, Bouverat, Brian, Leeuwenburgh, Christiaan, Lu, Ching-ju, Pahor, Marco, Hsu, Fang-Chi, Rushing, Scott, Walkup, Michael P, Nicklas, Barbara, Rejeski, W Jack, Williams, John P, Xia, Ashley, Albertson, Brent G, Barton, Elisabeth R, Booth, Frank W, Caputo, Tiziana, Cicha, Michael, De Sousa, Luis Gustavo Oliveira, Farrar, Roger, Hevener, Andrea L, Hirshman, Michael F, Jackson, Bailey E, Ke, Benjamin G, Kramer, Kyle S, Lessard, Sarah J, Makarewicz, Nathan S, Marshall, Andrea G, and Nigro, Pasquale
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Health Sciences ,Sports Science and Exercise ,Prevention ,Human Genome ,Cardiovascular ,Behavioral and Social Science ,Genetics ,Physical Activity ,2.1 Biological and endogenous factors ,1.1 Normal biological development and functioning ,Generic health relevance ,Inflammatory and immune system ,Good Health and Well Being ,Animals ,Female ,Humans ,Male ,Rats ,Acetylation ,Blood ,Cardiovascular Diseases ,Databases ,Factual ,Endurance Training ,Epigenome ,Inflammatory Bowel Diseases ,Internet ,Lipidomics ,Metabolome ,Mitochondria ,Multiomics ,Non-alcoholic Fatty Liver Disease ,Organ Specificity ,Phosphorylation ,Physical Conditioning ,Animal ,Physical Endurance ,Proteome ,Proteomics ,Time Factors ,Transcriptome ,Ubiquitination ,Wounds and Injuries ,MoTrPAC Study Group ,Lead Analysts ,MoTrPAC Study Group ,General Science & Technology - Abstract
Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood1-3. Here, the Molecular Transducers of Physical Activity Consortium4 profiled the temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome and immunome in whole blood, plasma and 18 solid tissues in male and female Rattus norvegicus over eight weeks of endurance exercise training. The resulting data compendium encompasses 9,466 assays across 19 tissues, 25 molecular platforms and 4 training time points. Thousands of shared and tissue-specific molecular alterations were identified, with sex differences found in multiple tissues. Temporal multi-omic and multi-tissue analyses revealed expansive biological insights into the adaptive responses to endurance training, including widespread regulation of immune, metabolic, stress response and mitochondrial pathways. Many changes were relevant to human health, including non-alcoholic fatty liver disease, inflammatory bowel disease, cardiovascular health and tissue injury and recovery. The data and analyses presented in this study will serve as valuable resources for understanding and exploring the multi-tissue molecular effects of endurance training and are provided in a public repository ( https://motrpac-data.org/ ).
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- 2024
14. Resisting Concepts as Starting Points in a High School Leadership Pathway Alongside Indigenous Youth
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Dubnewick, Michael, Lessard, Sean, Hopper, Tristan, and Lewis, Brian
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This writing draws on an ongoing narrative inquiry with 10 Indigenous youth as they negotiated their lives within a high school leadership pathway. Our research demonstrates the need to resist starting in concepts as an intentional shift to being and becoming wakeful to storied lives on and off school landscapes. Three resonant threads are highlighted as we listened across the youths' lives. These threads are framed as pathways the youth asked us to consider in terms of reimagining schools as places of unfolding kinship, reimagining schools beyond notions of becoming responsible adults, and reimagining in-between spaces as landscapes that matter.
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- 2023
15. Improving Teacher Health and Well-Being: Mixed Methods Outcomes Evaluation of the Be Well Care Well Program
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Moreland, Angela, Schnake, Kerrie, Lessard, Laura, Davies, Faraday, Prowell, Katelyn, and Hubel, Grace S.
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- 2024
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16. Toward a Better Understanding of Walking Speed in Ataxia of Charlevoix-Saguenay: a Factor Exploratory Study
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Lessard, Isabelle, Hébert, Luc J., St-Gelais, Raphaël, Côté, Isabelle, Mathieu, Jean, Brais, Bernard, and Gagnon, Cynthia
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- 2024
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17. Professional Representations of Collaboration in the Response to Intimate Partner Violence
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Lalande, Célyne, Gauthier, Sonia, Damant, Dominique, Lessard, Geneviève, and Dubé, Myriam
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- 2024
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18. CT analysis of aortic calcifications to predict abdominal aortic aneurysm rupture
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Mansouri, Mohamed, Therasse, Eric, Montagnon, Emmanuel, Zhan, Ying Olivier, Lessard, Simon, Roy, Aubert, Boucher, Louis-Martin, Steinmetz, Oren, Aslan, Emre, Tang, An, Chartrand-Lefebvre, Carl, and Soulez, Gilles
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- 2024
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19. Stochastic viability in an island model with partial dispersal : Approximation by a diffusion process in the limit of a large number of islands
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Kroumi, Dhaker and Lessard, Sabin
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Quantitative Biology - Populations and Evolution ,92D25, 60J70 - Abstract
In this paper, we study a finite population undergoing discrete, nonoverlapping generations, that is structured into $D$ demes, each containing $N$ individuals of two possible types, $A$ and $B$, whose viability coefficients, $s_A$ and $s_B$, respectively, vary randomly from one generation to the next. We assume that the means, variances and covariance of the viability coefficients are inversely proportional to the number of demes $D$, while higher-order moments are negligible in comparison to $1/D$. We use a discrete-time Markov chain with two time scales to model the evolutionary process, and we demonstrate that as the number of demes $D$ approaches infinity, the accelerated Markov chain converges to a diffusion process for any deme size $N\geq 2$. This diffusion process allows us to evaluate the fixation probability of type $A$ following its introduction as a single mutant in a population that was fixed for type $B$. We explore the impact of increasing the variability in the viability coefficients on this fixation probability. At least when $N$ is large enough, it is shown that increasing this variability for type $B$ or decreasing it for type $A$ leads to an increase in the fixation probability of a single $A$. The effect of the population-scaled variances, $\sigma^2_A$ and $\sigma^2_B$, can even cancel the effects of the population-scaled means, $\mu_A$ and $\mu_B$. We also show that the fixation probability of a single $A$ increases as the deme-scaled migration rate increases. Moreover, this probability is higher for type $A$ than for type $B$ if the population-scaled geometric mean is higher for type $A$ than for type $B$, which means that $\mu_A-\sigma_A^2/2>\mu_B-\sigma_B^2/2$.
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- 2023
20. Evolutionary game with stochastic payoffs in a finite island model
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Kroumi, Dhaker and Lessard, Sabin
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Quantitative Biology - Populations and Evolution ,92D25, 60J70 - Abstract
In this paper, we consider a two-player two-strategy game with random payoffs in a population subdivided into $d$ demes, each containing $N$ individuals at the beginning of any given generation and experiencing local extinction and recolonization with some fixed probability $m$ after reproduction and selection among offspring. Within each deme, offspring engage in random pairwise interactions, and the payoffs are assumed to have means and variances proportional to the inverse of the population size. By verifying the conditions given in Ethier and Nagylaki (1980) to approximate Markov chains with two time scales, we establish that the discrete-time evolutionary dynamics with $Nd$ generations as unit of time converges to a continuous-time diffusion as $d\rightarrow\infty$. The infinitesimal mean and variance of this diffusion are expressed in terms of the population-scaled means and variances of the payoffs besides identity-by-descent measures between offspring in the same deme in a neutral population. We show that the probability for a strategy to fix in the population starting from an initial frequency $(Nd)^{-1}$ generally increases as the payoffs to that strategy exhibit less variability or the payoffs to the other strategy more variability. As a result, differences in variability can make this fixation probability for cooperation larger than the corresponding one for defection. As the deme-scaled extinction rate $\nu=mN$ decreases for $N$ large enough and $m$ small enough, creating a higher level of identity among offspring within demes, the differences between the population-scaled variances of the payoffs for interacting offspring of different types increases this effect to a greater extent than the differences for interacting offspring of the same type.
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- 2023
21. Noise-induced stochastic Nash equilibrium
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Li, Cong, Feng, Tianjiao, Zheng, Xiudeng, Lessard, Sabin, and Tao, Yi
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Quantitative Biology - Populations and Evolution ,Mathematical Physics - Abstract
In order to better understand the impact of environmental stochastic fluctuations on the evolution of animal behavior, we introduce the concept of a stochastic Nash equilibrium (SNE) that extends the classical concept of a Nash equilibrium (NE). Based on a stochastic stability analysis of a linear evolutionary game with temporally varying payoffs, we address the question of the existence of a SNE, either weak when the geometric mean payoff against it is the same for all other strategies or strong when it is strictly smaller for all other strategies, and its relationship with a stochastically evolutionarily stable (SES) strategy. While a strong SNE is always SES, this is not necessarily the case for a weak SNE. We give conditions for a completely mixed weak SNE not to be SES and to coexist with at least two strong SNE. More importantly, we show that a pair of two completely mixed strong SNE can emerge as the noise level increases. This not only indicates that a noise-induced SNE may possess some properties that a NE cannot possess, such as being completely mixed and strong, but also illustrates the complexity of evolutionary game dynamics in a stochastic environment.
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- 2023
22. Model Predictive Planning: Trajectory Planning in Obstruction-Dense Environments for Low-Agility Aircraft
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Wallace, Matthew T., Streetman, Brett, and Lessard, Laurent
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Electrical Engineering and Systems Science - Systems and Control ,Computer Science - Robotics - Abstract
We present Model Predictive Planning (MPP), a trajectory planner for low-agility vehicles such as a fixed-wing aircraft to navigate obstacle-laden environments. MPP consists of (1) a multi-path planning procedure that identifies candidate paths, (2) a raytracing procedure that generates linear constraints around these paths to enforce obstacle avoidance, and (3) a convex quadratic program that finds a feasible trajectory within these constraints if one exists. Low-agility aircraft cannot track arbitrary paths, so refining a given path into a trajectory that respects the vehicle's limited maneuverability and avoids obstacles often leads to an infeasible optimization problem. The critical feature of MPP is that it efficiently considers multiple candidate paths during the refinement process, thereby greatly increasing the chance of finding a feasible and trackable trajectory. We demonstrate the effectiveness of MPP on a longitudinal aircraft model.
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- 2023
23. A Tutorial on the Structure of Distributed Optimization Algorithms
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Van Scoy, Bryan and Lessard, Laurent
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Mathematics - Optimization and Control ,Electrical Engineering and Systems Science - Systems and Control - Abstract
We consider the distributed optimization problem for a multi-agent system. Here, multiple agents cooperatively optimize an objective by sharing information through a communication network and performing computations. In this tutorial, we provide an overview of the problem, describe the structure of its algorithms, and use simulations to illustrate some algorithmic properties based on this structure., Comment: 6 pages, 14 figures, to appear at IEEE Conference on Decision and Control 2023
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- 2023
24. A Tutorial on a Lyapunov-Based Approach to the Analysis of Iterative Optimization Algorithms
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Van Scoy, Bryan and Lessard, Laurent
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Mathematics - Optimization and Control ,Electrical Engineering and Systems Science - Systems and Control - Abstract
Iterative gradient-based optimization algorithms are widely used to solve difficult or large-scale optimization problems. There are many algorithms to choose from, such as gradient descent and its accelerated variants such as Polyak's Heavy Ball method or Nesterov's Fast Gradient method. It has long been observed that iterative algorithms can be viewed as dynamical systems, and more recently, as robust controllers. Here, the "uncertainty" in the dynamics is the gradient of the function being optimized. Therefore, worst-case or average-case performance can be analyzed using tools from robust control theory, such as integral quadratic constraints (IQCs). In this tutorial paper, we show how such an analysis can be carried out using an alternative Lyapunov-based approach. This approach recovers the same performance bounds as with IQCs, but with the added benefit of constructing a Lyapunov function., Comment: 6 pages, 3 figures, to appear at IEEE Conference on Decision and Control 2023
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- 2023
25. Automated Lyapunov Analysis of Primal-Dual Optimization Algorithms: An Interpolation Approach
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Van Scoy, Bryan, Simpson-Porco, John W., and Lessard, Laurent
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Mathematics - Optimization and Control ,Electrical Engineering and Systems Science - Systems and Control - Abstract
Primal-dual algorithms are frequently used for iteratively solving large-scale convex optimization problems. The analysis of such algorithms is usually done on a case-by-case basis, and the resulting guaranteed rates of convergence can be conservative. Here we consider a class of first-order algorithms for linearly constrained convex optimization problems, and provide a linear matrix inequality (LMI) analysis framework for certifying worst-case exponential convergence rates. Our approach builds on recent results for interpolation of convex functions and linear operators, and our LMI directly constructs a Lyapunov function certifying the guaranteed convergence rate. By comparing to rates established in the literature, we show that our approach can certify significantly faster convergence for this family of algorithms., Comment: 6 pages, 2 figures, to appear at IEEE Conference on Decision and Control 2023
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- 2023
26. Non-negative Matrix Factorization using Partial Prior Knowledge for Radiation Dosimetry
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Lessard, Boby, Marcotte, Frédéric, Lalonde, Arthur, Therriault-Proulx, François, Lambert-Girard, Simon, Beaulieu, Luc, and Archambault, Louis
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Physics - Medical Physics - Abstract
Hyperspectral unmixing aims at decomposing a given signal into its spectral signatures and its associated fractional abundances. To improve the accuracy of this decomposition, algorithms have included different assumptions depending on the application. The goal of this study is to develop a new unmixing algorithm that can be applied for the calibration of multi-point scintillation dosimeters used in the field of radiation therapy. This new algorithm is based on a non-negative matrix factorization. It incorporates a partial prior knowledge on both the abundances and the endmembers of a given signal. It is shown herein that, following a precise calibration routine, it is possible to use partial prior information about the fractional abundances, as well as on the endmembers, in order to perform a simplified yet precise calibration of these dosimeters. Validation and characterization of this algorithm is made using both simulations and experiments. The experimental validation shows an improvement in accuracy compared to previous algorithms with a mean spectral angle distance (SAD) on the estimated endmembers of 0.0766, leading to an average error of $(0.25 \pm 0.73)$ % on dose measurements., Comment: 12 pages, 6 figures
- Published
- 2023
27. Determination of stable branches of relative equilibria of the $N$-vortex problem on the sphere
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Constantineau, Kevin, García-Azpeitia, Carlos, García-Naranjo, Luis C, and Lessard, Jean-Philippe
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Mathematics - Dynamical Systems ,Mathematical Physics ,70K42, 76M60, 65G30, 65G20, 47H10, 37C25 - Abstract
We consider the $N$-vortex problem on the sphere assuming that all vorticities have equal strength. We investigate relative equilibria (RE) consisting of $n$ latitudinal rings which are uniformly rotating about the vertical axis with angular velocity $\omega$. Each such ring contains $m$ vortices placed at the vertices of a concentric regular polygon and we allow the presence of additional vortices at the poles. We develop a framework to prove existence and orbital stability of branches of RE of this type parametrised by $\omega$. Such framework is implemented to rigorously determine and prove stability of segments of branches using computer-assisted proofs. This approach circumvents the analytical complexities that arise when the number of rings $n\geq 2$ and allows us to give several new rigorous results. We exemplify our method providing new contributions consisting in the determination of enclosures and proofs of stability of several equilibria and RE for $5\leq N\leq 12$., Comment: 60 pages. Second version includes a Data Accessibility Statement and a link to a GitHub repository where the code to reproduce the computer assisted proofs is available
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- 2023
28. People with HIV at the end-of-life and their next-of-kin/loved ones are willing to participate in interventional HIV cure-related research
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Ndukwe, Samuel O, Patel, Hursch, Shelton, Brittany, Concha-Garcia, Susanna, Dullano, Cheryl, Solso, Stephanie, Hendrickx, Steven, Riggs, Patricia K, Villa, Thomas J, Kaytes, Andy, Taylor, Jeff, Little, Susan J, Lessard, David, Arora, Anish K, Costiniuk, Cecilia T, Eskaf, Shadi, Smith, Davey M, Gianella, Sara, and Dubé, Karine
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Biomedical and Clinical Sciences ,Immunology ,Clinical Research ,Infectious Diseases ,HIV/AIDS ,Clinical Trials and Supportive Activities ,Good Health and Well Being ,Humans ,United States ,HIV Infections ,Surveys and Questionnaires ,Cognition ,Death ,altruism ,end of life ,HIV cure research ,Last Gift ,rapid research autopsy ,socio-behavioral research ,willingness to participate ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Virology ,Biomedical and clinical sciences ,Health sciences - Abstract
IntroductionThe Last Gift study at the University of California San Diego (UCSD), United States enrolls terminally ill people with HIV (PWH) in HIV cure research.MethodsFrom 2017 to 2022, we conducted surveys with Last Gift participants and their next-of-kin/loved ones to evaluate willingness to participate in different types of HIV cure research at the end of life (EOL). We analyzed willingness data descriptively.ResultsWe surveyed 17 Last Gift participants and 17 next-of-kin/loved ones. More than half of Last Gift participants ( n = 10; 58.8%) expressed willingness to participate in studies involving totally new treatments or approaches ('first-in-human' studies), a combination of different approaches, the use of unique antibodies, proteins or molecules, or therapeutic vaccines. Under one-quarter of Last Gift participants ( n = 4; 23.5%) expressed willingness to participate in research involving interventions that may shorten their life expectancy to benefit medical research. Most Last Gift participants and their next-of-kin/loved ones also expressed high acceptance for various types of donations and biopsies at the EOL (e.g. hair donations and skin, lymph node or gut biopsies).DiscussionKnowing whether people would be willing to participate in different types of EOL HIV cure research can help inform the design of future innovative studies. As a research community, we have a duty to design studies with adequate safeguards to preserve the public trust in research and honor PWH's important gift to humanity.
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- 2024
29. Zinc finger nuclease-mediated gene editing in hematopoietic stem cells results in reactivation of fetal hemoglobin in sickle cell disease
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Samuel Lessard, Pauline Rimmelé, Hui Ling, Kevin Moran, Benjamin Vieira, Yi-Dong Lin, Gaurav Manohar Rajani, Vu Hong, Andreas Reik, Richard Boismenu, Ben Hsu, Michael Chen, Bettina M. Cockroft, Naoya Uchida, John Tisdale, Asif Alavi, Lakshmanan Krishnamurti, Mehrdad Abedi, Isobelle Galeon, David Reiner, Lin Wang, Anne Ramezi, Pablo Rendo, Mark C. Walters, Dana Levasseur, Robert Peters, Timothy Harris, and Alexandra Hicks
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Medicine ,Science - Abstract
Abstract BIVV003 is a gene-edited autologous cell therapy in clinical development for the potential treatment of sickle cell disease (SCD). Hematopoietic stem cells (HSC) are genetically modified with mRNA encoding zinc finger nucleases (ZFN) that target and disrupt a specific regulatory GATAA motif in the BCL11A erythroid enhancer to reactivate fetal hemoglobin (HbF). We characterized ZFN-edited HSC from healthy donors and donors with SCD. Results of preclinical studies show that ZFN-mediated editing is highly efficient, with enriched biallelic editing and high frequency of on-target indels, producing HSC capable of long-term multilineage engraftment in vivo, and express HbF in erythroid progeny. Interim results from the Phase 1/2 PRECIZN-1 study demonstrated that BIVV003 was well-tolerated in seven participants with SCD, of whom five of the six with more than 3 months of follow-up displayed increased total hemoglobin and HbF, and no severe vaso-occlusive crises. Our data suggest BIVV003 represents a compelling and novel cell therapy for the potential treatment of SCD.
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- 2024
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30. ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency
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Ishtiaque Hossain, Pierre Priam, Sofia C. Reynoso, Sahil Sahni, Xiao X. Zhang, Laurence Côté, Joelle Doumat, Candus Chik, Tianxin Fu, Julie A. Lessard, and William A. Pastor
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Science - Abstract
Abstract The primed epiblast acts as a transitional stage between the relatively homogeneous naïve epiblast and the gastrulating embryo. Its formation entails coordinated changes in regulatory circuits driven by transcription factors and epigenetic modifications. Using a multi-omic approach in human embryonic stem cell models across the spectrum of peri-implantation development, we demonstrate that the transcription factors ZIC2 and ZIC3 have overlapping but essential roles in opening primed-specific enhancers. Together, they are essential to facilitate progression to and maintain primed pluripotency. ZIC2/3 accomplish this by recruiting SWI/SNF to chromatin and loss of ZIC2/3 or degradation of SWI/SNF both prevent enhancer activation. Loss of ZIC2/3 also results in transcriptome changes consistent with perturbed Polycomb activity and a shift towards the expression of genes linked to differentiation towards the mesendoderm. Additionally, we find an intriguing dependency on the transcriptional machinery for sustained recruitment of ZIC2/3 over a subset of primed-hESC specific enhancers. Taken together, ZIC2 and ZIC3 regulate highly dynamic lineage-specific enhancers and collectively act as key regulators of human primed pluripotency.
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- 2024
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31. Synthesis and conformational analysis of pyran inter-halide analogues of ᴅ-talose
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Olivier Lessard, Mathilde Grosset-Magagne, Paul A. Johnson, and Denis Giguère
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organofluorine ,pyran inter-halide ,solid-state conformation ,solution-state conformation ,Science ,Organic chemistry ,QD241-441 - Abstract
In this work, we describe the synthesis of halogenated pyran analogues of ᴅ-talose using a halo-divergent strategy from known 1,6-anhydro-2,3-dideoxy-2,3-difluoro-β-ᴅ-mannopyranose. In solution and in the solid-state, all analogues adopt standard 4C1-like conformations despite 1,3-diaxial repulsion between the F2 and the C4 halogen. Moreover, the solid-state conformational analysis of halogenated pyrans reveals deviation in the intra-annular torsion angles arising from repulsion between the axial fluorine at C2 and the axial halogen at C4, which increases with the size of the halogen at C4 (F < Cl < Br < I). Crystal packing arrangements of pyran inter-halides show hydrogen bond acceptor and nonbonding interactions for the halogen at C4. Finally, density functional theory (DFT) calculations corroborate the preference of talose analogues to adopt a 4C1-like conformation and a natural bonding orbital (NBO) analysis demonstrates the effects of hyperconjugation from C–F antibonding orbitals.
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- 2024
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32. Worrisome Properties of Neural Network Controllers and Their Symbolic Representations
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Cyranka, Jacek, Church, Kevin E M, and Lessard, Jean-Philippe
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Mathematics - Dynamical Systems ,Mathematics - Optimization and Control - Abstract
We raise concerns about controllers' robustness in simple reinforcement learning benchmark problems. We focus on neural network controllers and their low neuron and symbolic abstractions. A typical controller reaching high mean return values still generates an abundance of persistent low-return solutions, which is a highly undesirable property, easily exploitable by an adversary. We find that the simpler controllers admit more persistent bad solutions. We provide an algorithm for a systematic robustness study and prove existence of persistent solutions and, in some cases, periodic orbits, using a computer-assisted proof methodology., Comment: accepted to ECAI23
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- 2023
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33. Where are the Water Worlds?: Self-Consistent Models of Water-Rich Exoplanet Atmospheres
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Kempton, Eliza M. -R., Lessard, Madeline, Malik, Matej, Rogers, Leslie A., Futrowsky, Kate E., Ih, Jegug, Marounina, Nadejda, and Muñoz-Romero, Carlos E.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
It remains to be ascertained whether sub-Neptune exoplanets primarily possess hydrogen-rich atmospheres or whether a population of H$_2$O-rich "water worlds" lurks in their midst. Addressing this question requires improved modeling of water-rich exoplanetary atmospheres, both to predict and interpret spectroscopic observations and to serve as upper boundary conditions on interior structure calculations. Here we present new models of hydrogen-helium-water atmospheres with water abundances ranging from solar to 100% water vapor. We improve upon previous models of high water content atmospheres by incorporating updated prescriptions for water self-broadening and a non-ideal gas equation of state. Our model grid (https://umd.box.com/v/water-worlds) includes temperature-pressure profiles in radiative-convective equilibrium, along with their associated transmission and thermal emission spectra. We find that our model updates primarily act at high pressures, significantly impacting bottom-of-atmosphere temperatures, with implications for the accuracy of interior structure calculations. Upper atmosphere conditions and spectroscopic observables are less impacted by our model updates, and we find that under most conditions, retrieval codes built for hot Jupiters should also perform well on water-rich planets. We additionally quantify the observational degeneracies among both thermal emission and transmission spectra. We recover standard degeneracies with clouds and mean molecular weight for transmission spectra, and we find thermal emission spectra to be more readily distinguishable from one another in the water-poor (i.e. near-solar) regime., Comment: Accepted for publication in ApJ. Full model grid is available at https://umd.box.com/v/water-worlds
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- 2023
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34. Zinc finger nuclease-mediated gene editing in hematopoietic stem cells results in reactivation of fetal hemoglobin in sickle cell disease
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Lessard, Samuel, Rimmelé, Pauline, Ling, Hui, Moran, Kevin, Vieira, Benjamin, Lin, Yi-Dong, Rajani, Gaurav Manohar, Hong, Vu, Reik, Andreas, Boismenu, Richard, Hsu, Ben, Chen, Michael, Cockroft, Bettina M., Uchida, Naoya, Tisdale, John, Alavi, Asif, Krishnamurti, Lakshmanan, Abedi, Mehrdad, Galeon, Isobelle, Reiner, David, Wang, Lin, Ramezi, Anne, Rendo, Pablo, Walters, Mark C., Levasseur, Dana, Peters, Robert, Harris, Timothy, and Hicks, Alexandra
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- 2024
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35. ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency
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Hossain, Ishtiaque, Priam, Pierre, Reynoso, Sofia C., Sahni, Sahil, Zhang, Xiao X., Côté, Laurence, Doumat, Joelle, Chik, Candus, Fu, Tianxin, Lessard, Julie A., and Pastor, William A.
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- 2024
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36. Knowledge and practices of youth awareness on death and dying in school settings: a systematic scoping review protocol
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Allard, Emilie, Coupat, Clémence, Lessard, Sabrina, Therrien, Noémie, Godard-Sebillotte, Claire, Létourneau, Dimitri, Nguyen, Olivia, Côté, Andréanne, Fortin, Gabrielle, Daneault, Serge, Soulières, Maryse, Le Gall, Josiane, and Fortin, Sylvie
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- 2024
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37. Can you be a peer if you don’t share the same health or social conditions? A qualitative study on peer integration in a primary care setting
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Lessard, Émilie, O’Brien, Nadia, Panaite, Andreea-Catalina, Leclaire, Marie, Castonguay, Geneviève, Rouly, Ghislaine, and Boivin, Antoine
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- 2024
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38. Patient-reported outcomes and experiences of migrants enrolled in a multidisciplinary HIV clinic with rapid, free, and onsite treatment dispensation: the ‘ASAP’ study
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Arora, Anish K., Vicente, Serge, Engler, Kim, Lessard, David, Huerta, Edmundo, Ishak, Joel, Kronfli, Nadine, Routy, Jean-Pierre, Cox, Joseph, Lemire, Benoit, Klein, Marina, de Pokomandy, Alexandra, Del Balso, Lina, Sebastiani, Giada, Vedel, Isabelle, Quesnel-Vallée, Amélie, and Lebouché, Bertrand
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- 2024
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39. Short term supplementation with cranberry extract modulates gut microbiota in human and displays a bifidogenic effect
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Lessard-Lord, Jacob, Roussel, Charlène, Lupien-Meilleur, Joseph, Généreux, Pamela, Richard, Véronique, Guay, Valérie, Roy, Denis, and Desjardins, Yves
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- 2024
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40. Immune checkpoint inhibitors and risk of immune-mediated adverse events: a cohort study comparing extended versus standard interval administration
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Lessard-Roy, Amélia, Marchand, Roxanne, Lemieux, Pierre, Masse, Mélanie, Lacerte, Alexandre, Carmichael, Pierre-Hugues, and Laurin, Danielle
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- 2024
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41. Elucidation of the role of metals in the adsorption and photodegradation of herbicides by metal-organic frameworks
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Chiu, Nan Chieh, Lessard, Jacob M., Musa, Emmanuel Nyela, Lancaster, Logan S., Wheeler, Clara, Krueger, Taylor D., Chen, Cheng, Gallagher, Trenton C., Nord, Makenzie T., Huang, Hongliang, Cheong, Paul Ha-Yeon, Fang, Chong, and Stylianou, Kyriakos C.
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- 2024
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42. Author Correction: A multiplexed, paired-pooled droplet digital PCR assay for detection of SARS-CoV-2 in saliva
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Wagner, Kaitlyn, Fox, Phil, Gordon, Elizabeth, Hahn, Westen, Olsen, Kenzie, Markham, Alex, Buglewicz, Dylan, Selemenakis, Platon, Lessard, Avery, Goldstein, Daniella, Threatt, Alissa, Davis, Luke, Miller-Dawson, Jake, Stockett, Halie, Sanders, Hailey, Rugh, Kristin, Turner, Houston, Remias, Michelle, Williams, Maggie, Chavez, Jorge, Galindo, Gabriel, Cialek, Charlotte, Koch, Amanda, Fout, Alex, Fosdick, Bailey, Broeckling, Bettina, and Zabel, Mark D.
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- 2024
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43. Marine fishes experiencing high-velocity range shifts may not be climate change winners
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Chaikin, Shahar, Riva, Federico, Marshall, Katie E., Lessard, Jean-Philippe, and Belmaker, Jonathan
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- 2024
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44. Natural History of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay: a 4-Year Longitudinal Study
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Lessard, Isabelle, Côté, Isabelle, St-Gelais, Raphaël, Hébert, Luc J., Brais, Bernard, Mathieu, Jean, Rodrigue, Xavier, and Gagnon, Cynthia
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- 2024
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45. Sexual Minority Youth Reporting SOGIE-Based Harassment to Adults at School: The Roles of Experienced Harassment, Outness, Safety, and Adult Support at School
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McCauley, Peter S., Lessard, Leah M., Babcock, Nikole, Sun, Nora, Eaton, Lisa A., and Watson, Ryan J.
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- 2024
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46. Constraining the Thickness of the Atmosphere of TRAPPIST-1 b from its JWST Secondary Eclipse Observation
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Ih, Jegug, Kempton, Eliza M. -R., Whittaker, Emily A., and Lessard, Madeline
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Recently, the first JWST measurement of thermal emission from a rocky exoplanet was reported. The inferred dayside brightness temperature of TRAPPIST-1 b at 15 $\mu$m is consistent with the planet having no atmosphere and therefore no mechanism by which to circulate heat to its nightside. In this Letter, we compare the measured secondary eclipse depth of TRAPPIST-1 b to predictions from a suite of self-consistent radiative-convective equilibrium models in order to quantify the maximum atmospheric thickness consistent with the observation. We find that plausible atmospheres (i.e., those that contain at least 100 ppm CO$_2$) with surface pressures greater than 0.01 bar (0.1 bar) are ruled out at 1$\sigma$ (3$\sigma$), regardless of the choice of background atmosphere. Thicker atmospheres of up to 10 bar (100 bar) at 1$\sigma$ (3$\sigma$) are only allowed if the atmosphere lacks any strong absorbers across the mid-IR wavelength range, a scenario that we deem unlikely. We additionally model the emission spectra for bare-rock planets of various compositions. We find that a variety of silicate surfaces match the measured eclipse depth to within 1$\sigma$, and the best-fit grey albedo is $0.02 \pm 0.11$. We conclude that planned secondary eclipse observations at 12.8 $\mu$m will serve to validate the high observed brightness temperature of TRAPPIST-1 b, but are unlikely to further distinguish among the consistent atmospheric and bare-rock scenarios., Comment: 8 pages, 4 figures, submitted to ApJL
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- 2023
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47. Guaranteed Stability Margins for Decentralized Linear Quadratic Regulators
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Kashyap, Mruganka and Lessard, Laurent
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Electrical Engineering and Systems Science - Systems and Control ,Mathematics - Optimization and Control - Abstract
It is well-known that linear quadratic regulators (LQR) enjoy guaranteed stability margins, whereas linear quadratic Gaussian regulators (LQG) do not. In this letter, we consider systems and compensators defined over directed acyclic graphs. In particular, there are multiple decision-makers, each with access to a different part of the global state. In this setting, the optimal LQR compensator is dynamic, similar to classical LQG. We show that when sub-controller input costs are decoupled (but there is possible coupling between sub-controller state costs), the decentralized LQR compensator enjoys similar guaranteed stability margins to classical LQR. However, these guarantees disappear when cost coupling is introduced.
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- 2023
48. Numerical computation of transverse homoclinic orbits for periodic solutions of delay differential equations
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Hénot, Olivier, Lessard, Jean-Philippe, and James, Jason D. Mireles
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Mathematics - Dynamical Systems - Abstract
We present a computational method for studying transverse homoclinic orbits for periodic solutions of delay differential equations, a phenomenon that we refer to as the \emph{Poincar\'{e} scenario}. The strategy is geometric in nature, and consists of viewing the connection as the zero of a nonlinear map, such that the invertibility of its Fr\'{e}chet derivative implies the transversality of the intersection. The map is defined by a projected boundary value problem (BVP), with boundary conditions in the (finite dimensional) unstable and (infinite dimensional) stable manifolds of the periodic orbit. The parameterization method is used to compute the unstable manifold and the BVP is solved using a discrete time dynamical system approach (defined via the \emph{method of steps}) and Chebyshev series expansions. We illustrate this technique by computing transverse homoclinic orbits in the cubic Ikeda and Mackey-Glass systems.
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- 2023
49. Concurrent Photooxidation and Photoreduction of Catechols and Para-Quinones by Chlorophyll Metabolites
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Katherine Phan, Emily E. Lessard, Joseph A. Reed, Meredith G. Warsen, Soren Zimmer, and Lisa M. Landino
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catechol ,quinone ,singlet oxygen ,photoreduction ,chlorophyll ,pheophorbide a ,Chemistry ,QD1-999 - Abstract
Photosynthesis is initiated when the sun’s light induces electron transfer from chlorophyll to plastoquinone, a para-quinone. While photosynthesis occurs in the intact chloroplasts of living plants, similar photochemical reactions between dietary chlorophyll metabolites and quinones are likely and may affect health outcomes. Herein, we continue our studies of the direct photoreduction of para-quinones and ortho-quinones that were generated by the photo-oxidation of catechols. Chlorophyll metabolites, including pheophorbide A, chlorin e6, and pyropheophorbide A, as well as methylene blue were employed as photosensitizers. We detected hydrogen peroxide using horseradish peroxidase following the photo-oxidation of the catechol dopamine, even in the presence of EDTA, a tertiary amine electron donor. Under ambient oxygen, hydrogen peroxide was also detected after the photoreduction of several para-quinones, including 2,3-dimethoxy-5-methyl-p-benzoquinone (CoQ0), methoxy-benzoquinone, and methyl-benzoquinone. The combinations of methylene blue and EDTA or pheophorbide A and triethanolamine as the electron donor in 20% dimethylformamide were optimized for photoreduction of the para-quinones. Chlorin e6 and pyropheophorbide A were less effective for the photoreduction of CoQ0 but were equivalent to pheophorbide A for generating hydrogen peroxide in photo-oxidation reactions with photosensitizers, oxygen, and triethanolamine. We employed dinitrophenylhydrazine to generate intensely colored adducts of methoxy-benzoquinone, methyl-benzoquinone, and 1,4-benzoquinone.
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- 2024
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50. Evaluation of the McGill‐Tongji Blended Education Program for Teacher Leaders in General Practice: The importance of partnership and contextualization in International Primary Care Training Initiatives
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Ziyue Wang, Xinxin Zhao, Huixia Shen, Hao Wang, Gemma Cheng, Ya Ning Gao, Wenzhen Zuo, Zhuyin Xu, Francesco Avallone, Anish K. Arora, Manxi Guo, Rachel Simmons, David Lessard, Theresa Beesley, Jialin C. Zheng, Bertrand Lebouché, and Howard Bergman
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primary care ,general practice ,continuing professional development ,contextualization ,international partnership ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Purpose Strong primary health care (PHC) systems require well‐established PHC education systems to enhance the skills of general practitioners (GPs). However, the literature on the experiences of international collaboration in primary care education in low‐ and middle‐income countries remains limited. The purpose of this study was to evaluate the implementation and perceived impact of the McGill‐Tongji Blended Education Program for Teacher Leaders in General Practice (referred to as the “Tongji Program”). Methods In 2020–2021, the McGill Department of Family Medicine (Montreal, Canada) and Tongji University School of Medicine (TUSM, Shanghai, China) jointly implemented the Tongji Program in Shanghai, China to improve the teaching capacity of PHC teachers. We conducted an exploratory longitudinal case study with a mixed methods design for the evaluation. Quantitative (QUAN) data was collected through questionnaire surveys and qualitative (QUAL) data was collected through focus group discussions. Results The evaluation showed that learners in Tongji Program were primarily female GPs (21/22,95%) with less than 4 years of experience in teaching (16/22,73%). This program was considered a successful learning experience by most participants (19/22, 86%) with higher order learning tasks such as critical thinking and problem‐solving. They also agreed that this program helped them feel more prepared to teach (21/22,95%), and developed a positive attitude toward primary care (21/22,95%). The QUAL interview revealed that both the Tongji and McGill organizers noted that TUSM showed strong leadership in organization, education, and coordination. Both students and teachers agreed that by adapting training content into contextualized delivery formats and settings, the Tongji Program successfully overcame language and technology barriers. Conclusions Committed partnerships and contextualization were key to the success of the Tongji Program. Future research should focus on how international primary care education programs affect learners' behavior in their practice settings, and explore barriers and facilitators to change.
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- 2024
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