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This article reviews the regulation of lead in drinking water, highlighting its epidemiological, engineering, and ethical aspects with a focus on the Flint water crisis. We first discuss water quality policy and its implementation with a focus on lead contamination of water, primarily from pipe systems between a water treatment facility and a tap. We then discuss physicians' roles and ethical responsibilities regarding safe drinking water using a human rights framework. We argue that physicians can play an important role in safeguarding drinking water in their communities by being vigilant, honoring the community's trust in them, and warning, educating, and empowering patients and broader communities so as to protect tap water safety and public health.

British shorthair (BSH) kittens in multiple litters died as a result of a severe non-neoplastic lymphoproliferative disease that showed many similarities with human autoimmune lymphoproliferative syndrome (ALPS). Human ALPS is caused by inherited defects in FAS-mediated lymphocyte apoptosis and the possibility of similar defects was investigated in BSH cats. The whole genomes of two affected kittens were sequenced and compared to 82 existing cat genomes. Both BSH kittens had homozygous insertions of an adenine within exon 3 of the FAS-ligand gene. The resultant frameshift and premature stop codon were predicted to result in a severely truncated protein that is unlikely to be able to activate FAS. Three additional affected BSH kittens were homozygous for the variant, while 11 of 16 unaffected, but closely related, BSH cats were heterozygous for the variant. All BSH cats in the study were from a population with significant inbreeding. The variant was not identified in a further survey of 510 non-BSH cats. Identification of a genetic defect in the FAS-mediated apoptosis pathway confirms that the lymphoproliferative disease in BSH cats fulfills the diagnostic criteria for ALPS in humans. These results will enable the development of a genetic test to detect BSH carrier animals.

[1] This paper presents a tool for calculating the Palmer Drought Severity Index (PDSI) and associated drought indices. The PDSI is a widely used drought index, yet the complexity and lack of transparency associated with the calculation of the PDSI makes it difficult for a researcher to independently calculate the index. Researchers are often forced to use PDSI values supplied by the National Climatic Data Center (NCDC) of the National Oceanic and Atmospheric Administration (NOAA) or some other third party. The MATLAB tool presented here is easy to use, thoroughly documented, and transparent. The tool was developed by checking an independently developed code against NCDC's FORTRAN code. Discrepancies between the MATLAB tool and the NCDC code are documented. Researchers using the tool will be able to easily calculate the Palmer drought indices for data inputs of any length and at any spatial scale.

Tetraglyme (TG) and the recently developed trimethylsilyl capped analogue (1NM3) when used as additives in a N-methyl-N-propylpyrrolidinium bis(trifluoromethylsulfonyl) amide [C3mpyr][NTf2]/0.65 M ...

Water scarcity is intensified by drought, a phenomenon that impacts many sectors of society and affects virtually all climate zones. The Palmer drought indices are widely used by scientists and policy makers to understand drought and model its components. Despite the spatial heterogeneity and variability in variables required by the Palmer model, regional index values are most commonly used for real-time drought assessment. Local stakeholders charged with developing flexible and tailored water management policies have articulated the need for drought indices calculated at finer spatial resolutions than a regional scale. We use the Pacific Northwest United States (U.S.) as a study area to demonstrate the differences between drought indices calculated for U.S. climate divisions with those calculated at a 0.5° by 0.5° latitude/longitude resolution. Our results indicate that regional values of the two cumulative Palmer drought indices do not represent finer-resolution values well. For half of the study area, the pictures of drought (as determined by regional and finer-resolution values) are drastically different more than 30% of the time. Thus, quite often water managers do not have a clear understanding of the relative severity of drought in their area, which can have serious implications for drought mitigation and adaptation.

A 22-year-old captive Brazilian rainbow boa (Epicrates cenchria cenchria) gave birth to four offspring after being housed with a vasectomized male. Sexual reproduction as a result of failed prior vasectomy, recanalization of the vas deferens, or prolonged sperm storage was ruled out using the clinical history, histopathology, and gross necropsy. Short tandem repeat (STR) DNA markers were genotyped in the male, female, and four offspring. None of the offspring possessed a diagnostic STR allele present in the potential sire. In addition, all offspring were homozygous at each STR locus evaluated, supporting parthenogenetic reproduction. This is the first report of parthenogenesis in a Brazilian rainbow boa and has implications for the conservation of reptiles maintained in captive breeding programs.