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117 results on '"Leslie, R.D.G."'

3. Importance of persistent cellular and humoral immune changes before diabetes develops: prospective study of identical twins

Author

Tun, R.Y.M., Peakman, M., Alviggi, L., Hussain, M.J., Shattock, M., Lo, S.S.S., Pyke, D.A., Bottazzo, G.F., Vergani, D., and Leslie, R.D.G.

Subjects
T cells, Cellular immunity -- Abnormalities, Autoantibodies, Diabetes -- Risk factors, Health, Risk factors, Abnormalities
Abstract

Abstract Objectives--To determine the pattern of cellular and humoral immune changes associated with insulin dependent diabetes before diabetes develops. Design--Prospective study over 10 years of 25 non-diabetic identical twins of [...]

Published
1994

5. Molecular Pathology of Diabetes Mellitus

Author

Leslie, R.D.G and Leslie, R.D.G

Subjects
Diabetes--Pathogenesis, Diabetes--Molecular aspects, Diabetse--Etiology, Diabetes Mellitus, Insulin-Dependent--etiology, Diabetes Mellitus, Non-Insulin-Dependent--etiolo
Abstract

Diabetes, already a prevalent disease worldwide, is increasing at a rate consistent with a global epidemic. The number of people affected is expected to double in the next 15 years to about 200 million. The disease is already one of the commonest causes of kidney failure, blindness and amputations. There is an urgent need to prevent either the development of these complications or the disease itself. Dramatic advances in our understanding of the pathogenesis of diabetes have led to the hope that diabetes can indeed be prevented. Several major international collaborative projects have been initiated with this aim. In this book, an outstanding group of international scientists provide a broad outline of the advances in basic science which underpin these projects. The book offers a clear, comprehensive and up-to-date account for the interested clinician and scientist, and will be invaluable as a reference book for those working in the field.

Published
2015

6. Nitric Oxide Synthesis and Isoprostane Production in Subjects With Type 1 Diabetes and Normal Urinary Albumin Excretion

Author

O'Byrne, Sharon, Forte, Pablo, Roberts, L. Jackson II, Morrow, Jason D., Johnston, Atholl, Anggard, Eric, Leslie, R.D.G., and Benjamin, Nigel

Subjects
Nitric oxide -- Physiological aspects, Type 1 diabetes -- Development and progression, Health
Abstract

The role of nitric oxide (NO) and free radicals in the development of microvascular disease in type 1 diabetes remains unclear. We have measured NO and isoprostane (a stable marker [...]

Published
2000

14. Escaping insulin dependent diabetes: characteristic immunological changes don't invariably lead to disease

Author

Leslie, R.D.G. and Pyke, D.A.

Subjects
Diabetes in youth -- Diagnosis -- Prevention, Type 1 diabetes -- Physiological aspects -- Prevention -- Diagnosis, Diabetes in children -- Diagnosis -- Prevention, Teenagers -- Diagnosis -- Physiological aspects, Youth -- Diagnosis -- Physiological aspects, Health, Diagnosis, Prevention, Physiological aspects
Abstract

Insulin dependent diabetes mellitus is caused by an immunologically mediated destruction of the β cells in the islets of Langerhans. The disease process is associated with immune changes in the [...]

Published
1991

25. CORRESPONDENCE.

Author

Henryk-Gutt, Rita, Salk, J., Merry, J., Knowles, M., Beard, R.W., Paintin, D.B., Alderman, B., Mulley, G.P., Mitchell, J.R.A., Feinstein, A.R., Seppalainen, Anna M., Herxheimer, H.G.J., Heathcote, J.G., Hamlyn, A.N., Scott, R.A.M., Leslie, R.D.G., Coats, P.M., and Prentice, Gwen M.

Subjects
PUBLIC health, PSYCHIATRIC hospital care
Abstract

Features correspondence related to public health in Europe. Criticism to psychiatric hospitals on patient accommodation; Disadvantage of oral live poliovirus vaccine; Reports on lithium treatment and thyrotoxicosis; Topics on abortion; Sterilisation in women.

Published
1977

26. Immune changes associated with insulin dependent diabetes may remit without causing the disease: a study of identical twins.

Author

Millward, B.A., Alviggi, L., Hoskins, P.J., Johnston, C., Heaton, D., Bottazzo, G.F., Vergani, D., Leslie, R.D.G., and Pyke, D.A.

Subjects
T cells, ISLANDS of Langerhans, IMMUNOLOGICAL tolerance, METABOLISM, PHYSIOLOGY
Abstract

Reports the immune changes associated with insulin dependent diabetes in identical twins. Activation of the T lymphocytes and islet cell antibodies; Comparison on the glucose intolerance of long and short term group of twin pairs; Evaluations on the immunological tests performed.

Published
1986
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27. Metabolic abnormalities in children of non-insulin dependent diabetics.

Author

Leslie, R.D.G., Volkmann, H.P., Poncher, M., Hanning, I., Orskov, H., and Alberti, K.G.M.M.

Subjects
*METABOLIC disorders, *PEOPLE with diabetes, *JUVENILE diseases, *INSULIN
Abstract

Examines the metabolic abnormalities in children of non-insulin dependent diabetics. Impairment in glucose tolerance; Capability of young offspring of non-insulin dependent diabetics to show metabolic changes; Association of the changes with hyperinsulinemia hyperglucagonemia.

Published
1986
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28. Height at diagnosis of diabetes in children: a study in identical twins.

Author

Hoskins, P.J., Leslie, R.D.G., and Pyke, D.A.

Subjects
*TWINS, *DIABETES in children, *DWARFISM, *HEALTH
Abstract

Examines the heights of identical twins discordant for insulin dependent diabetes during the diagnosis of the diabetic twin in London, England. Differences in height between the twins; Causes of growth retardation; Delay of growth due to the metabolic abnormalities associated with diabetes.

Published
1985
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29. Chlorpropamide-alcohol flushing: a dominantly inherited trait associated with diabetes.

Author

Leslie, R.D.G. and Pyke, D.A.

Subjects
*TYPE 2 diabetes, *CHLORPROPAMIDE, *PEOPLE with diabetes
Abstract

Investigates the association between facial flushing following chlorpropamide intake and non-insulin-dependent diabetes. Reasons for the dominance of chlorpropamide-alcohol flushing (CPAF); Conduction of tests among pairs of identical twins; Difference in the incidence of CPAF among non-insulin-dependent diabetics.

Published
1978
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30. Hypothalamo-pituitary-thyroid function in anorexia nervosa: influence of weight gain.

Author

Leslie, R.D.G., Isaacs, A.J., Gomez, J., Raggatt, P.R., and Bayliss, Richard

Subjects
*ANOREXIA nervosa, *HYPOTHALAMIC-pituitary-thyroid axis, *THYROXINE
Abstract

Assesses the functional state of the hypothalamo-pituitary-thyroid axis of women with anorexia nervosa. Influence of weight gain on the disease; Identification of mean serum thyroxine concentrations; Response of thyrotrophin releasing hormone on thyroid concentration.

Published
1978
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31. Asthma induced by enkephalin.

Author

Leslie, R.D.G., Bellamy, David, and Pyke, David A.

Subjects
*ASTHMA, *ENKEPHALINS, *OPIOID peptides, *PHYSIOLOGY
Abstract

Examines asthma induced by enkephalin. Prevention of asthmatic reactions; Details on the mediation of opiate peptides; Causes of asthma.

Published
1980
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32. Anti-keratin antibodies in rheumatoid arthritis.

Author

Young, B.J.J., Mallya, R.K., Leslie, R.D.G., Clark, C.J.M., and Hamblin, T.J.

Subjects
KERATIN, THERAPEUTIC use of immunoglobulins, RHEUMATOID arthritis, PATIENTS
Abstract

Examines the occurrence of anti-keratin antibodies in patients with rheumatoid arthritis. Detection of the antibody; Diagnosis of patients with rheumatoid arthritis; Treatment of rheumatoid arthritis.

Published
1979
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37. BETA-CELL FUNCTION IN TYPE II DIABETES

Author

Ferner, R.E, primary, Jarrett, R.J, additional, Leslie, R.D.G, additional, O'Rahilly, S.P, additional, Nugent, Z, additional, Rudenski, A.S, additional, Hosker, J.P, additional, and Turner, R.C, additional

Published
1986
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48. Manual of Dietetic Practice

Author

Leslie, R.D.G.

Subjects
Manual of Dietetic Practice (Book) -- Book reviews, Books -- Book reviews
Published
1988

49. Causes of insulin dependent diabetes.

Author

Leslie, R.D.G. and Harrison, Douglas

Subjects
*DIABETES, *GENES, *IMMUNE system, *VIRUSES, *ETIOLOGY of diseases, *PHYSIOLOGY
Abstract

Focuses on the etiology of insulin dependent diabetes. Influences of genes in the development of the disease; Role of the immune system on the clinical course of the ailment; Relation between virus and diabetes.

Published
1983
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50. Chlorpropamide-alcohol flushing: a definition of its relation to non-insulin-dependent diabetes.

Author

Pyke, D.A. and Leslie, R.D.G.

Subjects
*TYPE 2 diabetes, *CHLORPROPAMIDE, *PROVOCATION tests (Medicine)
Abstract

Investigates the correlation between chlorpropamide-alcohol flushing (CPAF) and non-insulin-dependent diabetes. Precedence of CPAF on the appearance of diabetes; Detection of the syndrome with a single-challenge test; Inheritance of the syndrome through the study of diabetic people.

Published
1978
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