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294 results on '"Lesesve, Jean-François"'

4. Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53

Author

Chapiro, Elise, Pramil, Elodie, Diop, M'boyba, Roos-Weil, Damien, Dillard, Clémentine, Gabillaud, Clémentine, Maloum, Karim, Settegrana, Catherine, Baseggio, Lucile, Lesesve, Jean-François, Yon, Mélanie, Jondreville, Ludovic, Lesty, Claude, Davi, Frédéric, Le Garff-Tavernier, Magali, Droin, Nathalie, Dessen, Philippe, Algrin, Caroline, Leblond, Véronique, Gabarre, Jean, Bouzy, Simon, Eclache, Virginie, Gaillard, Baptiste, Callet-Bauchu, Evelyne, Muller, Marc, Lefebvre, Christine, Nadal, Nathalie, Ittel, Antoine, Struski, Stéphanie, Collonge-Rame, Marie-Agnès, Quilichini, Benoit, Fert-Ferrer, Sandra, Auger, Nathalie, Radford-Weiss, Isabelle, Wagner, Lena, Scheinost, Sebastian, Zenz, Thorsten, Susin, Santos A., Bernard, Olivier A., and Nguyen-Khac, Florence

Published
2019
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8. Retrospective analysis of a cohort of 41 de novo B-cell prolymphocytic leukemia patients: impact of genetics and targeted therapies (a FILO study)

Author

Algrin, Caroline, primary, Pérol, Louis, additional, Chapiro, Elise, additional, Baseggio, Lucile, additional, Maloum, Karim, additional, Settegrana, Catherine, additional, Lesesve, Jean-François, additional, Siavellis, Justine, additional, Delmer, Alain, additional, Michallet, Anne-Sophie, additional, Ferrant, Emmanuelle, additional, Feugier, Pierre, additional, Tomowiak, Cécile, additional, Brion, Annie, additional, Ghez, David, additional, Fornecker, Luc-Matthieu, additional, Ivanoff, Sarah, additional, Struski, Stéphanie, additional, Sutton, Laurent, additional, Radford-Weiss, Isabelle, additional, Eclache, Virginie, additional, Lefebvre, Christine, additional, Leblond, Véronique, additional, Nguyen-Khac, Florence, additional, and Roos-Weil, Damien, additional

Published
2022
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10. Perls’ Stain Guidelines from the French-Speaking Cellular Hematology Group (GFHC)

Author

Lours, Camille, primary, Cottin, Laurane, additional, Wiber, Margaux, additional, Andrieu, Valérie, additional, Baccini, Véronique, additional, Baseggio, Lucile, additional, Brouzes, Chantal, additional, Chatelain, Bernard, additional, Daliphard, Sylvie, additional, Fenneteau, Odile, additional, Geneviève, Franck, additional, Girard, Sandrine, additional, Leymarie, Vincent, additional, Maloum, Karim, additional, Rieu, Jean-Baptiste, additional, Sebahoun, Gérard, additional, Sudaka, Isabelle, additional, Troussard, Xavier, additional, Wagner-Ballon, Orianne, additional, Wuilleme, Soraya, additional, Bardet, Valérie, additional, and Lesesve, Jean-François, additional

Published
2022
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11. Perls' Stain Guidelines from the French-Speaking Cellular Hematology Group (GFHC).

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Laboratoire de biologie clinique, Lours, Camille, Cottin, Laurane, Wiber, Margaux, Andrieu, Valérie, Baccini, Véronique, Baseggio, Lucile, Brouzes, Chantal, Chatelain, Bernard, Daliphard, Sylvie, Fenneteau, Odile, Geneviève, Franck, Girard, Sandrine, Leymarie, Vincent, Maloum, Karim, Rieu, Jean-Baptiste, Sebahoun, Gérard, Sudaka, Isabelle, Troussard, Xavier, Wagner-Ballon, Orianne, Wuilleme, Soraya, Bardet, Valérie, Lesesve, Jean-François, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Laboratoire de biologie clinique, Lours, Camille, Cottin, Laurane, Wiber, Margaux, Andrieu, Valérie, Baccini, Véronique, Baseggio, Lucile, Brouzes, Chantal, Chatelain, Bernard, Daliphard, Sylvie, Fenneteau, Odile, Geneviève, Franck, Girard, Sandrine, Leymarie, Vincent, Maloum, Karim, Rieu, Jean-Baptiste, Sebahoun, Gérard, Sudaka, Isabelle, Troussard, Xavier, Wagner-Ballon, Orianne, Wuilleme, Soraya, Bardet, Valérie, and Lesesve, Jean-François

Abstract

In order to standardize cellular hematology practices, the French-speaking Cellular Hematology Group (Groupe Francophone d'Hématologie Cellulaire, GFHC) focused on Perls' stain. A national survey was carried out, leading to the proposal of recommendations on insoluble iron detection and quantification in bone marrow. The criteria presented here met with a "strong professional agreement" and follow the suggestions of the World Health Organization's classification of hematological malignancies.

Published
2022

23. Use of the multiparametric panel CD3/CD4/CD8/CD7/CD26/CD158k in the detection and use of flow cytometry of Sezary cells

Author

Callet, Jonas, additional, Latger-Cannard, Véronique, additional, Gérard, Delphine, additional, Salignac, Sylvain, additional, Granel-Brocard, Florence, additional, Campidelli, Arnaud, additional, Bursztejn, Anne-Claire, additional, Broséus, Julien, additional, Vial, Jean-Philippe, additional, and Lesesve, Jean-François, additional

Published
2021
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39. Platelet Counting: Ugly Traps and Good Advice. Proposals from the French-Speaking Cellular Hematology Group (GFHC)

Author

Baccini, Véronique, primary, Geneviève, Franck, additional, Jacqmin, Hugues, additional, Chatelain, Bernard, additional, Girard, Sandrine, additional, Wuilleme, Soraya, additional, Vedrenne, Aurélie, additional, Guiheneuf, Eric, additional, Toussaint-Hacquard, Marie, additional, Everaere, Fanny, additional, Soulard, Michel, additional, Lesesve, Jean-François, additional, and Bardet, Valérie, additional

Published
2020
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44. Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving and MYC and TP53

Author

Chapiro, Elise, Pramil, Elodie, Diop, M'boyba, Roos-Weil, Damien, Dillard, Clémentine, Gabillaud, Clémentine, Maloum, Karim, Settegrana, Catherine, Baseggio, Lucile, Lesesve, Jean-François, Yon, Mélanie, Jondreville, Ludovic, Lesty, Claude, Davi, Frederic, Le Garff-Tavernier, Magali, Droin, Nathalie, Dessen, Philippe, Algrin, Caroline, Leblond, Veronique, Gabarre, Jean, Bouzy, Simon, Eclache, Virginie, Gaillard, Baptiste, Callet-Bauchu, Evelyne, Muller, Marc, Lefebvre, Christine, Nadal, Nathalie, Ittel, Antoine, Struski, Stephanie, Collonge-Rame, Marie-Agnès, et al, and University of Zurich

Subjects
1307 Cell Biology, 2403 Immunology, 1303 Biochemistry, 10032 Clinic for Oncology and Hematology, 2720 Hematology, 610 Medicine & health
Published
2019

45. Nuclear winter

Author

Lesesve, Jean-François and Mansuy, Ludovic

Published
2005

46. Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving and MYC and TP53

Author

Chapiro, Elise; https://orcid.org/0000-0003-3427-7596, Pramil, Elodie, Diop, M'boyba, Roos-Weil, Damien; https://orcid.org/0000-0002-7767-755X, Dillard, Clémentine, Gabillaud, Clémentine, Maloum, Karim; https://orcid.org/0000-0001-8864-4801, Settegrana, Catherine, Baseggio, Lucile; https://orcid.org/0000-0001-7543-6480, Lesesve, Jean-François, Yon, Mélanie, Jondreville, Ludovic, Lesty, Claude, Davi, Frederic; https://orcid.org/0000-0002-3764-063X, Le Garff-Tavernier, Magali; https://orcid.org/0000-0002-3131-3240, Droin, Nathalie, Dessen, Philippe, Algrin, Caroline, Leblond, Veronique, Gabarre, Jean, Bouzy, Simon, Eclache, Virginie, Gaillard, Baptiste, Callet-Bauchu, Evelyne, Muller, Marc, Lefebvre, Christine, Nadal, Nathalie, Ittel, Antoine, Struski, Stephanie, Collonge-Rame, Marie-Agnès, et al, Chapiro, Elise; https://orcid.org/0000-0003-3427-7596, Pramil, Elodie, Diop, M'boyba, Roos-Weil, Damien; https://orcid.org/0000-0002-7767-755X, Dillard, Clémentine, Gabillaud, Clémentine, Maloum, Karim; https://orcid.org/0000-0001-8864-4801, Settegrana, Catherine, Baseggio, Lucile; https://orcid.org/0000-0001-7543-6480, Lesesve, Jean-François, Yon, Mélanie, Jondreville, Ludovic, Lesty, Claude, Davi, Frederic; https://orcid.org/0000-0002-3764-063X, Le Garff-Tavernier, Magali; https://orcid.org/0000-0002-3131-3240, Droin, Nathalie, Dessen, Philippe, Algrin, Caroline, Leblond, Veronique, Gabarre, Jean, Bouzy, Simon, Eclache, Virginie, Gaillard, Baptiste, Callet-Bauchu, Evelyne, Muller, Marc, Lefebvre, Christine, Nadal, Nathalie, Ittel, Antoine, Struski, Stephanie, Collonge-Rame, Marie-Agnès, and et al

Abstract

B-cell prolymphocytic leukemia (B-PLL) is a rare hematological disorder whose underlying oncogenic mechanisms are poorly understood. Our cytogenetic and molecular assessment of 34 patients with B-PLL revealed several disease-specific features and potential therapeutic targets. The karyotype was complex ({greater than or equal to}3 abnormalities) in 73% of the patients and highly complex (5 abnormalities) in 45%. The most frequent chromosomal aberrations were translocations involving [t()] (62%), deletion (del)17p (38%), trisomy (tri)18 (30%), del13q (29%), tri3 (24%), tri12 (24%), and del8p (23%). Twenty-six of the 34 patients (76%) exhibit aberration, resulting from mutually exclusive translocations or gains. Whole-exome sequencing revealed frequent mutations in , , , , , , , , and The majority of B-PLL used the or subgroups (89%), and displayed significantly mutated genes (79%). We identified three distinct cytogenetic risk groups: low-risk (no aberration), intermediate-risk ( aberration but no del17p), and high-risk ( aberration and del17p) (p=.0006). drug response profiling revealed that the combination of a B-cell receptor or BCL2 inhibitor with OTX015 (a bromodomain and extra-terminal motif (BET) inhibitor targeting ) was associated with significantly lower viability of B-PLL cells harboring a t(). We conclude that cytogenetic analysis is a useful diagnostic and prognostic tool in B-PLL. Targeting may be a useful treatment option in this disease.

Published
2019

47. 2021 update of the 2012 ICSH Recommendations for identification, diagnostic value, and quantitation of schistocytes: Impact and revisions.

Author

Zini, Gina, d'Onofrio, Giuseppe, Erber, Wendy N., Lee, Szu‐Hee, Nagai, Yutaka, Basak, Grzegorz W., and Lesesve, Jean‐François

Subjects
CONSENSUS (Social sciences), REFERENCE values, AUTOANALYZERS, ERYTHROCYTES, THROMBOCYTOPENIA, COLLECTION & preservation of biological specimens
Abstract

In 2012, the International Council for Standardization in Hematology (ICSH) published recommendations for the identification, quantitation, and diagnostic value of schistocytes. In the present review, the impact of these recommendations is evaluated. This work is based on citations in peer‐reviewed papers published since 2012. The first 2012 ICSH Recommendations have also been revised to incorporate newly published data in the literature and current best laboratory practice. Recommended reference ranges have been proposed for healthy adults and full‐term neonates of 1% or less schistocytes. More than 1% of morphologically identified schistocytes on the blood film are considered suspicious for thrombotic microangiopathy. For preterm infants, a normal level of 5% or less is recommended. The fragment red cell count (FRC) generated by some automated hematological analyzers provides a valuable screening tool for the presence of schistocytes. Specifically, the absence of FRCs can be used as a valuable parameter to exclude the presence of schistocytes on the blood film. The validity and usefulness of microscope schistocytes and automated FRCs, respectively, are discussed in the context of the laboratory diagnostic tests used for thrombotic microangiopathies. [ABSTRACT FROM AUTHOR]

Published
2021
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