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Holliday junction recognition protein (HJURP) is a key molecular chaperone for centromere protein A (CENP-A), which is essential for chromosome separation during mitosis and cell cycle regulation. Recent studies have identified the essential role of HJURP in carcinogenesis. Abnormal upregulation of HJURP expression has been observed in various human cancers, such as non-small cell lung cancer (NSCLC), hepatocellular carcinoma (HCC), bladder cancer, and breast cancer, and is associated with poor pathologic development and prognosis. In vitro and in vivo studies have shown that HJURP mainly exerts oncogenic functions by regulating the cell cycle, cellular senescence, and epithelial-mesenchymal transition (EMT). The purpose of this review was to evaluate the prognostic significance of HJURP in human cancers and summarize anti-tumor studies targeting HJURP. The factors regulating HJURP in carcinogenesis and the corresponding effects are also discussed to provide new insight into targeting HJURP as a promising strategy for cancer treatment.

Agarwood from Aquilaria plants, also known as Chen Xiang (沉香), is traditionally used for the treatment of abdominal pain and as a sedative. Because of the great demand and the rareness of agarwood, extensive harvesting of Aquilaria plants has nearly led to the extinction of the species. To fully utilize this resource, the use of different parts of Aquilaria needs to be investigated. This article will focus on the pharmacological properties and the mechanism of action of different parts of Aquilaria plants.