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1. Feed your microbiome and your heart: The gut-heart axis

Author

Lerner Aaron, Steigerwald Christian, and Matthias Torsten

Subjects
heart, gut, microbiome, cardiovascular disease, nutrition, mechanisms, pathways, review, Biochemistry, QD415-436, Biology (General), QH301-705.5
Abstract

Cardiovascular and metabolic diseases are the leading causes of disability, morbidity, and mortality worldwide. Genetics plays an important role, but environmental factors change the game and hold the potential for prevention, reversibility, and applied therapy. Nutrition, phenotype, and behavior of microorganisms, intestinal eco-events, and intestinal permeability play a crucial role in the induction of diseases. The present mini-review summarizes nutrients, diets, microbial manipulations, and tight junction function modifiers that might prevent, modulate, or treat certain diseases.

Published
2020
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2. Microbial Transglutaminase Is Immunogenic and Potentially Pathogenic in Pediatric Celiac Disease

Author

Matthias Torsten and Lerner Aaron

Subjects
celiac disease, microbiome, food additive, gluten, cross linking, microbial transglutaminase, Pediatrics, RJ1-570
Abstract

The enzyme microbial transglutaminase is heavily used in the food processing industries to ameliorate food qualities and elongate the products' shelf life. As a protein's glue, it cross-links gliadin peptides, creating neo-complexes that are immunogenic and potentially pathogenic to celiac disease communities. Even lacking sequence identity, it imitates functionally the endogenous tissue transglutaminase, known to be the autoantigen of celiac disease and representing an undisputable key player in celiac disease initiation and progress. The present review expend on the enzyme characteristics, exogenous intestinal sources, its cross-linking avidity to gluten or gliadin, turning naïve protein to immunogenic ones. Several observation on microbial transglutaminase cross linked complexes immunogenicity in celiac patients are reviewed and its pathogenicity is summarized. Warnings on its potential risks for the gluten dependent conditions are highlighted. When substantiated, it might represent a new environmental factor of celiac disease genesis. It is hoped that the presented knowledge will encourage further research to explore the mechanism and the pathogenic pathways taken by the gliadin cross linked enzyme in driving celiac disease.

Published
2018
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5. List of contributors

Author

Adiguzel, Yekbun, primary, Andreoli, Laura, additional, Antonelli, Eleonora, additional, Athanassiou, Lambros, additional, Athanassiou, Panagiotis, additional, Avčin, Tadej, additional, Babel, Nina, additional, Bechmann, Nicole, additional, Benzvi, Carina, additional, Bitsadze, Victoria, additional, Bogdanos, Dimitrios P., additional, Bonam, Srinivsasa Reddy, additional, Borba, Vânia, additional, Borghi, M.O., additional, Bornstein, Stefan R., additional, Bragazzi, Nicola Luigi, additional, Carrera-Bastos, Pedro, additional, Churilov, Leonid P., additional, Crisafulli, Francesca, additional, Cruz-Domínguez, María Pilar, additional, Cugno, M., additional, Danieli, MariaGiovanna, additional, Dardiotis, Efthymios, additional, David, Paula, additional, Davidy, Tal, additional, Della-Pina, Silvia-Ebe-Lucia, additional, Dotan, Arad, additional, Dragon-Durey, Marie-Agnès, additional, Efthymiou, Georgios, additional, Ehrenfeld, Michael, additional, Elalamy, Ismail, additional, Emeršič, Nina, additional, Evelina, Kamaeva, additional, Fontana, Giulia, additional, Franceschini, Franco, additional, Fremeaux-Bacchi, Véronique, additional, Fritzler, Marvin J., additional, Galaviz-Sánchez, Maria F., additional, Ganina, K.K., additional, Gavrilova, Natalia, additional, Giacomelli, Roberto, additional, Gris, Jean-Christophe, additional, Gutierrez-Melgarejo, Caroline I., additional, Horwitz, Ehud, additional, Israeli, Eitan, additional, Jacotot, Etienne, additional, Jara, Luis J., additional, Kanduc, Darja, additional, Kessel, Christoph, additional, Khizroeva, Jamilya, additional, Kolobov, Andrei, additional, Kostoglou-Athanassiou, Ifigenia, additional, Lapin, Sergey V., additional, Lasagni, G., additional, Lerner, Aaron, additional, Lev, Danielle Zemer, additional, Lidiia, Soprun, additional, López-Zamora, Berenice, additional, Lozano, Jose Manuel, additional, Lucas Hernández, Abihai, additional, Makatsariya, Alexander, additional, Malkova, Anna, additional, Maria, Lukashenko, additional, Mayorova, Margarita A., additional, Medina, Gabriela, additional, Meroni, P.L., additional, Mevorach, Dror, additional, Muller, Sylviane, additional, N. Petrova, Natalia, additional, Nikolenko, Vladimir N., additional, Ordinola Navarro, Alberto, additional, Ordoñez-González, Irvin, additional, Paladini, Alberto, additional, Pervakova, Margarita Y., additional, Perzon, Ofer, additional, Petrova, N.V., additional, Radic, Marko, additional, Rigopoulou, Eirini I., additional, Rodrigues-Fernandes, Jorge-Manuel, additional, Rosenberg, Avi, additional, Ruscitti, Piero, additional, Ryabkova, Varvara A., additional, Saia, Rafael Simone, additional, Sankov, Sergey V., additional, Sankova, Maria V., additional, Shoenfeld, Yehuda, additional, Sinelnikov, Mikhail Y., additional, Sobolevskaia, Polina, additional, Stervbo, Ulrik, additional, Talamini, Laura, additional, Tarasov, S.A., additional, Thurner, Lorenz, additional, Tincani, Angela, additional, Tkachenko, Olga Y., additional, Tocut, M., additional, Ursini, Francesco, additional, Vera-Lastra, Olga, additional, Vieira, Angelica Thomaz, additional, Vojdani, Aristo, additional, Vojdani, Elroy, additional, Watad, Abdulla, additional, Zandman-Goddard, G., additional, Zmira, Ofir, additional, and Zohar, Daniela Noa, additional

Published
2023
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8. Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

Author

Creteur, Jacques, Bogossian, Elisa Govea, Peluso, Lorenzo, González-Seguel, Felipe, Hidalgo-Calibin, Viviane, Carreño-Montenegro, Pablo, Rojas, Verónica, Tobar, Eduardo, Ramírez-Palma, Antonio, Herrera-Davis, Karen, Ferré, Alexis, Legriel, Stéphane, Godet, Thomas, Fraisse, Ugo, Gonçalves, Bruno, Mazeraud, Aurélien, Tzimou, Myrto, Rasulo, Frank, Beretta, Silvia, Marchesi, Mattia, Robba, Chiara, Battaglini, Denise, Pelosi, Paolo, Mazzeo, Anna Teresa, Noto, Alberto, Servillo, Giuseppe, Marra, Annachiara, Cutuli, Salvatore Lucio, Pintaudi, Gabriele, Stival, Eleonora, Tanzarella, Eloisa Sofia, Roman-Pognuz, Erik, Concetta Massaro, Chiara Maria, Elhadi, Muhammed, Smit, Lisa, Olasveengen, Theresa, Pereira, Isabel Jesus, Teixeira, Carla Margarida, Santos, Alice, Valente, Miguel, Granja, Cristina, Pereia, Rita, Silva, João, Furquet, Blanca, García Simón, Mónica, Godoy Torres, Daniel A, Monleón, Berta, Morcillo, Esteban, Romero, Nekane, Serrano, Ainhoa, Torrico Sánchez, Sara, Pérez Caballero, Francisco Luis, Peña Luna, Isabel, Baeza Gómez, Ignacio, Calizaya Vargas, Milagros, Morillas Pérez, Jordi, Carrasco Gómez, Genís, Molina Latorre, Ricard, Moya Gutiérrez, Sheila, Barón Barrera, Irene Patricia, Delgado Palacios, Cristina, García Góngora, Beatriz, Labrador Romero, Laura, Galarza, Laura, Catalán-Monzón, Ignacio, Rodriguez-Martínez, Enver, Murcia Gubianas, Cristina, Bellès, Ariadna, Rodriguez Delgado, María Esther, Caballero, Jesús, Morales, Dulce, Pujol, Andrés, Rubio, Jorge, Álvarez Torres, Eva, Carvajal Revuelta, Estefanía, de la Calle Gil, Isabel, Fernández Tomás, Blanca, Gallego Rodríguez, Berta, González Serrano, Matilde, LaTorre Andreu, Paloma, Pérez Lucendo, Aris, Abril Palomares, Elena, González González, Elena, Martín Delgado, María Cruz, Muñoz De Cabo, Carlos, Aznar, Pablo T., Calvo, Carlos A., Garutti, Ignacio, Higuero, Fernando, Martínez-Gascueña, David, Maseda, Emilio, Insausti, Itziar, Montero Feijoo, Ana, Suarez-de-la-Rica, Alejandro, Del Moral Barbudo, Beatriz, García Blanco-Traba, Yago, Giménez Santamarina, Maria Claudia, Gonzalo Millán, Alba, Llorente Damas, Sergio, Pestaña Lagunas, David, Reyes García, Isabel, Ruiz Perea, Alejandro, Ortega Guerrero, Álvaro, Mármol Cubillo, María Jesús, Díaz Muñoz, David, García de Castrillón i Ramal, Silvia, Andorrà Sunyer, Xavier, Noci Moreno, María de las Nieves, Pérez Manrique, Rosa María, del Campo Molina, Emilio, Martínez Quintana, María Elena, Fernandez-Gonzalo, Sol, Gomà Fernández, Gemma, Navarra-Ventura, Guillem, Baró Serra, Anna, Fuster, Cristina, Plans Galván, Oriol, Gil-Castillejos, Diana, Dalorzo González, Mario, Morán Gallego, Francisco Javier, Paredes Borrachero, Irene, Rodríguez Villamizar, Patricia, Romeu Prieto, Juan, Sánchez Carretero, María José, Gallardo Sánchez, Susana, Bustos Molina, Filadelfo, García Pérez, María Luisa, Castello-Mora, Paula, Puig, Jaume, Sanchis-Martin, María Rosa, Sanchis-Veryser, Carmen Andrea, Vicente-Fernández, María Pilar, Zaragoza, Rafael, Lizama, Laura, Torres, Irene, Álvarez, Cristina, Ramírez, Paula, Martin Cerezuela, Meri, Montero, María Jesús, García Cantos, Jose, Valls, Paola, Aretxabala Cortajarena, Nerea, García Domelo, Pablo, González Cubillo, Laura, Martín Martínez, Marta, Pérez Francisco, Inés, Poveda Hernández, Yolanda, Quintano Rodero, Amaia, Rodriguez Nuñez, César, Siegemund, Martin, Estermann, Anna, Zellweger, Núria, Ben Saida, Imen, Boussarsar, Mohamed, Esen, Figen, Ergin Özcan, Perihan, Berkey, Christopher, Harb, Christine, Tandy, Morgan H., Morgan, Ellis, Shephard, Karen, Hyzy, Robert C, Kenes, Michael, Nelson, Kristine, Hosse, Robert E., Vance, Katie M., Austin, C. Adrian, Lerner, Aaron, Sanders, Emily, Balk, Robert A, Bennett, David A, Vogel, Andrew R., Chowdhury, Lucia, Devulapally, Kiran, Woodham, Michelle, Cohen, Sarah, Patel, Nihal, Kuza, Catherine M., Sing, Mandeep, Roberson, Spencer, Drumright, Kelly, Sehgal, Sameep, LaHue, Sara C., Douglas, Vanja C., Sarwal, Aarti, Pun, Brenda T, Badenes, Rafael, Heras La Calle, Gabriel, Orun, Onur M, Chen, Wencong, Raman, Rameela, Simpson, Beata-Gabriela K, Wilson-Linville, Stephanie, Hinojal Olmedillo, Borja, Vallejo de la Cueva, Ana, van der Jagt, Mathieu, Navarro Casado, Rosalía, Leal Sanz, Pilar, Orhun, Günseli, Ferrer Gómez, Carolina, Núñez Vázquez, Karla, Piñeiro Otero, Patricia, Taccone, Fabio Silvio, Gallego Curto, Elena, Caricato, Anselmo, Woien, Hilde, Lacave, Guillaume, O'Neal, Hollis R, Jr, Peterson, Sarah J, Brummel, Nathan E, Girard, Timothy D, Ely, E Wesley, and Pandharipande, Pratik P

Published
2021
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10. Utilizing Telemedicine Applications in Celiac Disease and Other Gluten-Free-Diet-Dependent Conditions: Insights from the COVID-19 Pandemic.

Author

Haimi, Motti and Lerner, Aaron

Subjects
MOBILE apps, PATIENT compliance, GLUTEN-free diet, TELEMEDICINE, VIDEOCONFERENCING, COMMUNICATION, QUALITY of life, CELIAC disease, COVID-19 pandemic, SOCIAL classes
Abstract

Background: Globally, approximately 1.4% of people have celiac disease (CD), induced by gluten sensitivity. If left untreated, it causes small intestinal inflammation and villous atrophy, which can result in failure to thrive, anemia, osteoporosis, malabsorption, and even malignancy. The only treatment option available is a gluten-free diet (GFD). Few studies have looked at the role and perception of telehealth in relation to CD and selective nutrition both before and after the COVID-19 pandemic. Aim: Our goal was to screen and investigate the research conducted both before and after the COVID-19 pandemic concerning the utilization of telehealth applications and solutions in CD and other GFD-dependent circumstances. Methods: We employed a narrative review approach to explore articles that were published in scholarly journals or organizations between the years 2000 and 2024. Only English-language publications were included. PubMed and Google Scholar searches were mainly conducted using the following keywords: telemedicine, telehealth, telecare, eHealth, m-health, COVID-19, SARS-CoV-2, celiac disease, and gluten-free diet (GFD). Manual searches of the references in the acquired literature were also carried out, along with the authors' own personal contributions of their knowledge and proficiency in this field. Results: Only a few studies conducted prior to the COVID-19 outbreak examined the viewpoints and experiences of adult patients with CD with relation to in-person clinic visits, as well as other options such as telehealth. The majority of patients believed that phone consultations were appropriate and beneficial. Video conferencing and telemedicine became more popular during the COVID-19 pandemic, demonstrating the effectiveness of using these technologies for CD on a global basis. In recent years, urine assays for gluten identification have become accessible for use at home. These tests could be helpful for CD monitoring with telemedicine assistance. Conclusions: The extended knowledge gathered from the COVID-19 pandemic is expected to complement pre-COVID-19 data supporting the usefulness of telemedicine even after the emergent pandemic, encouraging its wider adoption in standard clinical practice. The monitoring and follow-up of CD patients and other GFD-dependent conditions can greatly benefit from telemedicine. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Multimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes

Author

Awasthi, Samir, Izu, Leighton T, Mao, Ziliang, Jian, Zhong, Landas, Trevor, Lerner, Aaron, Shimkunas, Rafael, Woldeyesus, Rahwa, Bossuyt, Julie, Wood, Brent M, Chen, Yi-Je, Matthews, Dennis L, Lieu, Deborah K, Chiamvimonvat, Nipavan, Lam, Kit S, Chen-Izu, Ye, and Chan, James W

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Cardiovascular, Heart Disease, Bioengineering, Aniline Compounds, Animals, Cardiomyopathies, Disease Models, Animal, Excitation Contraction Coupling, Fluorescent Dyes, Kinetics, Male, Mechanotransduction, Cellular, Membrane Microdomains, Mice, Microscopy, Confocal, Microscopy, Fluorescence, Multiphoton, Multimodal Imaging, Myocardial Contraction, Myocytes, Cardiac, Rats, Sprague-Dawley, Sarcomeres, Stress, Mechanical, Xanthenes, calcium signaling, cardiomyopathies, mechanotransduction, cellular, microscopy, fluorescence, multiphoton, multimodal imaging, myocardial contraction, sarcomeres, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

RationaleCardiac myocyte contraction is caused by Ca(2+) binding to troponin C, which triggers the cross-bridge power stroke and myofilament sliding in sarcomeres. Synchronized Ca(2+) release causes whole cell contraction and is readily observable with current microscopy techniques. However, it is unknown whether localized Ca(2+) release, such as Ca(2+) sparks and waves, can cause local sarcomere contraction. Contemporary imaging methods fall short of measuring microdomain Ca(2+)-contraction coupling in live cardiac myocytes.ObjectiveTo develop a method for imaging sarcomere level Ca(2+)-contraction coupling in healthy and disease model cardiac myocytes.Methods and resultsFreshly isolated cardiac myocytes were loaded with the Ca(2+)-indicator fluo-4. A confocal microscope equipped with a femtosecond-pulsed near-infrared laser was used to simultaneously excite second harmonic generation from A-bands of myofibrils and 2-photon fluorescence from fluo-4. Ca(2+) signals and sarcomere strain correlated in space and time with short delays. Furthermore, Ca(2+) sparks and waves caused contractions in subcellular microdomains, revealing a previously underappreciated role for these events in generating subcellular strain during diastole. Ca(2+) activity and sarcomere strain were also imaged in paced cardiac myocytes under mechanical load, revealing spontaneous Ca(2+) waves and correlated local contraction in pressure-overload-induced cardiomyopathy.ConclusionsMultimodal second harmonic generation 2-photon fluorescence microscopy enables the simultaneous observation of Ca(2+) release and mechanical strain at the subsarcomere level in living cardiac myocytes. The method benefits from the label-free nature of second harmonic generation, which allows A-bands to be imaged independently of T-tubule morphology and simultaneously with Ca(2+) indicators. Second harmonic generation 2-photon fluorescence imaging is widely applicable to the study of Ca(2+)-contraction coupling and mechanochemotransduction in both health and disease.

Published
2016

22. List of Contributors

Author

Afek, Arnon, primary, Afeltra, Antonella, additional, Afflitto, Gabriele Gallo, additional, Alessandri, Cristiano, additional, Alivernini, Stefano, additional, Alunno, Alessia, additional, Amital, Howard, additional, Andreoli, Laura, additional, Antonelli, Alessandro, additional, Arisi, Mariachiara, additional, Artusi, Carolina, additional, Atzeni, Fabiola, additional, Ballanti, Eleonora, additional, Barbati, Cristiana, additional, Barilaro, Giuseppe, additional, Bartoloni, Elena, additional, Ben-Ami, Dana, additional, Bettencourt, Andreia, additional, Bizzaro, Nicola, additional, Blank, Miri, additional, Bogdanos, Dimitrios P., additional, Boleixa, Daniela, additional, Borba, Vânia Vieira, additional, Borgiani, Paola, additional, Bragazzi, Nicola Luigi, additional, Brzosko, Iwona, additional, Brzosko, Marek, additional, Calzavara-Pinton, Piergiacomo, additional, Campi, Irene, additional, Cantarini, Luca, additional, Carranza-Muleiro, Rosa A., additional, Carvalho, Cláudia, additional, Caso, Francesco, additional, Ceccarelli, Fulvia, additional, Cervera, Ricard, additional, Chapman, Joab, additional, Chen, Xian, additional, Chimenti, Maria Sole, additional, Ciccacci, Cinzia, additional, Cipriano, Enrica, additional, Cohen Tervaert, Jan Willem, additional, Colasanti, Tania, additional, Conigliaro, Paola, additional, Conti, Fabrizio, additional, Coplan, Louis, additional, Costa, Luisa, additional, Croci, Stefania, additional, Cruz-Domínguez, María del Pilar, additional, Cutolo, Maurizio, additional, Dahan, Shani, additional, Damoiseaux, Jan, additional, De Carolis, Caterina, additional, Del Puente, Antonio, additional, Domingues, Vinicius, additional, Dreyfus, David H., additional, Drori, Tali, additional, Ehrenfeld, Michael, additional, Espinosa, Gerard, additional, Farina, Antonella, additional, Farina, Giuseppina Alessandra, additional, Ferraccioli, Gianfranco, additional, Finucci, Annacarla, additional, Fioravanti, Antonella, additional, Fischer, Katarzyna, additional, Fonti, Giulia Lavinia, additional, Francesca, Barone, additional, Franceschini, Franco, additional, Freire de Carvalho, Jozélio, additional, Fujio, Keishi, additional, García-Collinot, Grettel, additional, Generali, Elena, additional, Gerardi, Maria Chiara, additional, Gerli, Roberto, additional, Gertel, Smadar, additional, Giat, Eitan, additional, Greco, Elisabetta, additional, Gremese, Elisa, additional, Grunebaum, Eyal, additional, Gualtierotti, Roberta, additional, Guarino, Maria Domenica, additional, Guzner-Gur, Hanan, additional, He, Shu-Gui, additional, Iannuccelli, Cristina, additional, Jara, Luis J., additional, Jeandel, Pierre-Yves, additional, Kivity, Dr Shaye, additional, Kotyla, Przemyslaw J., additional, Krosser, Alec, additional, Latini, Andrea, additional, Leon-Ponte, Matilde, additional, Lerner, Aaron, additional, Levy, Roger Abramino, additional, Lichtbroun, Benjamin, additional, Lucchetti, Ramona, additional, Lu, Qianjin, additional, Margiotta, Domenico P.E., additional, Marinho, António, additional, Martínez-Bencomo, Michel A., additional, Matthias, Torsten, additional, Medina, Gabriela, additional, Meroni, Pier Luigi, additional, Lichtbroun, Michael, additional, Moreira Balbi, Gustavo Guimarães, additional, Muratore, Francesco, additional, Navarini, Luca, additional, Novelli, Giuseppe, additional, Pacucci, Viviana Antonella, additional, Peluso, Rosario, additional, Pendolino, Monica, additional, Pérez, Dolores, additional, Perricone, Carlo, additional, Perricone, Roberto, additional, Persani, Luca, additional, Petricca, Luca, additional, Pipitone, Nicolò, additional, Ramires de Jesús, Guilherme, additional, Resende, Gustavo, additional, Rizenbah, Chen, additional, Rodríguez-Pintó, Ignasi, additional, Rose, Noel R., additional, Rosenthal, Eric, additional, Rossi, Mariateresa, additional, Sakkas, Lazaros I., additional, Salvarani, Carlo, additional, Sarzi-Puttini, Piercarlo, additional, Scarpa, Raffaele, additional, Segal, Yahel, additional, Segel, Michael J., additional, Selmi, Carlo, additional, Seluk, Dr Lior, additional, Serena, Colafrancesco, additional, Sharabi, Amir, additional, Sharif, Kassem, additional, Shoenfeld, Netta, additional, Shoenfeld, Yehuda, additional, Signorelli, Flavio, additional, Silva, Ana Martins, additional, Silva, Berta Martins, additional, Slomovich, Sharon, additional, Somech, Raz, additional, Soriano, Alessandra, additional, Szekanecz, Zoltán, additional, Tanaka, Yoshiya, additional, Tenti, Sara, additional, Tincani, Angela, additional, Tolusso, Barbara, additional, Torres-Ruiz, Jiram, additional, Toubi, Elias, additional, Tozzoli, Renato, additional, Triggianese, Paola, additional, Trombetta, Amelia Chiara, additional, Tsokos, George C., additional, Tsuchida, Yumi, additional, Vadasz, Zahava, additional, Valesini, Guido, additional, van Beers, Joyce, additional, van Paassen, Pieter, additional, Vannucchi, Guia Maria, additional, Vasconcelos, Carlos, additional, Venturini, Marina, additional, Vera-Lastra, Olga, additional, Versini, Mathilde, additional, Vomero, Marta, additional, Watad, Abdulla, additional, Wu, Haijing, additional, and Zeng, Yong, additional

Published
2019
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26. Infantile-onset inflammatory bowel disease has variable long-term outcomes

Author

Krauthammer, Alex, primary, Weintraub, Ilana, additional, Shaoul, Ron, additional, Lev-Tzion, Raffi, additional, Broide, Efrat, additional, Wilschanski, Michael, additional, Lerner, Aaron, additional, Yerushalmi, Baruch, additional, Shouval, Dror S., additional, Shamaly, Hussein, additional, Haberman-Ziv, Yael, additional, and Weiss, Batia, additional

Published
2023
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28. Resveratrol in Rheumatological Diseases: A Systematic Review.

Author

Freire de Carvalho, Jozélio and Lerner, Aaron

Subjects
*RESVERATROL, *TUMOR necrosis factors, *RHEUMATISM, *JOINT diseases, *BLOOD sedimentation
Abstract

Resveratrol is an antioxidant with anti-inflammatory and cell-protective properties. The aim of our article is to review the use of resveratrol in rheumatic diseases. PubMed/Medline, Embase, and Scielo were screened for articles on resveratrol and rheumatic diseases in the period between of January 1966 and March 2023. Five articles were depicted, including 481 patients. The included diseases were osteoarthritis (n = 3), rheumatoid arthritis (n = 1), and Takayasu arteritis (n = 1). The age varied from 32 to 58.2 years, and the female gender ranged from 62% to 74% in the studies. Disease duration ranged from 3.5 ± 3.2 to 9.4 ± 5.8 years. The resveratrol dosage went from 250 mg to 1000 mg/day. All those articles demonstrated improvements in the diverse rheumatic diseases, including pain intensity, function, disease activity (DAS 28), swelling joints, and reduced inflammation markers (erythrocyte sedimentation rate, C-reactive protein, interleukinIL-1, IL-6, and tumor necrosis factor). No side effects were detected in all studies. In conclusion, resveratrol seems to be a safe therapy for various rheumatic diseases, although the evidence is very limited. The improved subjective and objective complaints and laboratory parameters are promising. However, there is a need to reconfirm, reproduce, and investigate the topic in more extensive, well-controlled, double-blind, cross-over studies. [ABSTRACT FROM AUTHOR]

Published
2023
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33. SARS-CoV-2 Gut-Targeted Epitopes: Sequence Similarity and Cross-Reactivity Join Together for Molecular Mimicry.

Author

Lerner, Aaron, Benzvi, Carina, and Vojdani, Aristo

Subjects
MOLECULAR mimicry, EPITOPES, VIRAL antigens, SARS-CoV-2, AUTOIMMUNE hepatitis
Abstract

The gastrointestinal tract can be heavily infected by SARS-CoV-2. Being an auto-immunogenic virus, SARS-CoV-2 represents an environmental factor that might play a role in gut-associated autoimmune diseases. However, molecular mimicry between the virus and the intestinal epitopes is under-investigated. The present study aims to elucidate sequence similarity between viral antigens and human enteric sequences, based on known cross-reactivity. SARS-CoV-2 epitopes that cross-react with human gut antigens were explored, and sequence alignment was performed against self-antigens implicated in enteric autoimmune conditions. Experimental SARS-CoV-2 epitopes were aggregated from the Immune Epitope Database (IEDB), while enteric antigens were obtained from the UniProt Knowledgebase. A Pairwise Local Alignment tool, EMBOSS Matcher, was employed for the similarity search. Sequence similarity and targeted cross-reactivity were depicted between 10 pairs of immunoreactive epitopes. Similar pairs were found in four viral proteins and seven enteric antigens related to ulcerative colitis, primary biliary cholangitis, celiac disease, and autoimmune hepatitis. Antibodies made against the viral proteins that were cross-reactive with human gut antigens are involved in several essential cellular functions. The relationship and contribution of those intestinal cross-reactive epitopes to SARS-CoV-2 or its potential contribution to gut auto-immuno-genesis are discussed. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Feed your microbiome and your heart: The gut-heart axis

Author

Lerner Aaron, Matthias Torsten, and Steigerwald Christian

Subjects
Intestinal permeability, Tight junction, Biology, Bioinformatics, medicine.disease, Phenotype, Gastrointestinal Microbiome, Cardiovascular Physiological Phenomena, Metabolic Diseases, medicine, Humans, Microbiome, Intestinal Mucosa, Function (biology)
Abstract

Cardiovascular and metabolic diseases are the leading causes of disability, morbidity, and mortality worldwide. Genetics plays an important role, but environmental factors change the game and hold the potential for prevention, reversibility, and applied therapy. Nutrition, phenotype, and behavior of microorganisms, intestinal eco-events, and intestinal permeability play a crucial role in the induction of diseases. The present mini-review summarizes nutrients, diets, microbial manipulations, and tight junction function modifiers that might prevent, modulate, or treat certain diseases.

Published
2021

43. Contributors

Author

Abdurakhmanov, Alexander, primary, Abu-Shakra, Mahmoud, additional, Afanasyeva, Marina, additional, Agmon-Levin, Nancy, additional, Albert, Paul J., additional, Almeida, Isabel, additional, Alves, Rute, additional, Amital, Howard, additional, Andrade, Paulo, additional, Antonelli, Alessandro, additional, Puccetti, Antonio, additional, Arango, María-Teresa, additional, Atzeni, Fabiola, additional, Baird, Alison E., additional, Balbir-Gurman, Alexandra, additional, Bashi, Tomer, additional, Batticciotto, Alberto, additional, Benucci, Maurizio, additional, Blank, Miri, additional, Bogdanos, Dimitrios P., additional, Bombardieri, S., additional, Borella, E., additional, Bosis, Samantha, additional, Bournia, Vasiliki Kalliopi, additional, Brandão, Mariana, additional, Braun-Moscovici, Yolanda, additional, Brender-Gotlieb, Neta, additional, Cainelli, Francesca, additional, Caldas, Cezar Augusto Muniz, additional, Campar, A., additional, Carvalheiras, Graziela, additional, Cervera, R., additional, Chapman, Joab, additional, Chastain, Emily M.L., additional, Claudio, Lunardi, additional, Cohen, Eytan, additional, Conti, Fabrizio, additional, Correia, J., additional, Carvalho, Jozélio Freire de, additional, Rossa, A. Della, additional, Detrick, Barbara, additional, Deutsch, Melanie, additional, Di Domenicantonio, Andrea, additional, Domeneghetti, M., additional, Domingues, Vital, additional, Doria, A., additional, Dow, Coad Thomas, additional, Dreyfus, David H., additional, Drouin, Elise E., additional, Dubaniewicz, Anna, additional, Durai, Malarvizhi, additional, Ebringer, Alan, additional, Ehrenfeld, Michael, additional, Elisa, Tinazzi, additional, Esposito, Susanna, additional, Fallahi, Poupak, additional, Faria, Raquel, additional, Farinha, Fátima, additional, Ferrannini, Ele, additional, Ferrari, Silvia Martina, additional, Ferreira, Alvaro, additional, Ferrão, C., additional, Garg, Ravindra Kumar, additional, Gatto, M., additional, Ghirardello, A., additional, Giovanna, Zanoni, additional, Giuseppe, Patuzzo, additional, Givaty, Gili, additional, Guilherme, Luiza, additional, Hammerstad, Sara Salehi, additional, Hodak, Emillia, additional, Hooks, John J., additional, Iaccarino, L., additional, Invernizzi, Pietro, additional, Israeli, Eitan, additional, Jamin, Christophe, additional, Janket, Sok-Ja, additional, Jarčuška, Peter, additional, Jones, Rodney P., additional, Kalil, Jorge, additional, Kanasi, Eleni, additional, Kivity, Shaye, additional, Konikoff, Tom, additional, Kozáková, D., additional, Krause, Ilan, additional, Lerner, Aaron, additional, Lidar, Merav, additional, Ling, Eduard, additional, Mahajna, Hussein, additional, Mahroum, Naim, additional, Maoz-Segal, Ramit, additional, Marinho, António, additional, Marshall, Trevor G., additional, Martinelli, Maria, additional, Marzia, Dolcino, additional, Mavragani, Clio P., additional, Mendonça, Teresa, additional, Miller, Stephen D., additional, Mimouni, Daniel, additional, Monteiro, Marta, additional, Moudgil, Kamal D., additional, Moulton, Vaishali R., additional, Moutsopoulos, Haralampos M., additional, Nagpal, Kamalpreet, additional, Neves, Esmeralda, additional, Nussenblatt, Robert, additional, Ollech, Ayelet, additional, Palma, L., additional, Pasoto, Sandra Gofinet, additional, Pella, Daniel, additional, Pereira, Cláudia, additional, Perricone, Carlo, additional, Petríková, Jana, additional, Proal, Amy D., additional, Rashid, Taha, additional, Reif, Shimon, additional, Renaudineau, Yves, additional, Ribeiro, Francinne Machado, additional, Rigante, Donato, additional, Rigopoulou, Eirini I., additional, Rose, Noel R., additional, Rosário, Cristina, additional, Rovenský, J., additional, Sakkas, Lazaros I., additional, Sarzi-Puttini, Piercarlo, additional, Seguro, Luciana Parente Costa, additional, Semino, Margherita, additional, Shoenfeld, Yehuda, additional, Silva, S., additional, Simonin, Laurent, additional, Smyk, Daniel S., additional, Sousa, Rita Catarina Medeiros, additional, Stagnaro, C., additional, Steere, Allen C., additional, Strle, Klemen, additional, Tektonidou, Maria G., additional, Tishler, Moshe, additional, Tomer, Yaron, additional, Toubi, Elias, additional, Tsokos, George C., additional, Vadasz, Zahava, additional, Valesini, Guido, additional, Vasconcelos, Carlos, additional, Vasconcelos, Júlia, additional, Vassilopoulos, Dimitrios, additional, Venkatesha, Shivaprasad H., additional, Vento, Sandro, additional, Viale, Christophe, additional, Villanueva, Ronald, additional, Vita, Pedro, additional, Wilson, Clyde, additional, Youinou, Pierre, additional, Záňová, E., additional, Zandman-Goddard, Gisele, additional, and Zen, M., additional

Published
2015
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45. Review – Nutraceuticals Can Target Asthmatic Bronchoconstriction: NADPH Oxidase-Dependent Oxidative Stress, RhoA and Calcium Dynamics

Author

McCarty,Mark F, DiNicolantonio,James J, and Lerner,Aaron

Subjects
Journal of Asthma and Allergy
Abstract

Mark F McCarty,1 James J DiNicolantonio,2 Aaron Lerner3 1Catalytic Longevity Foundation, San Diego, CA, USA; 2Department of Preventive Cardiology, Saint Luke’s Mid America Heart Institute, Kansas, MO, USA; 3Chaim Sheba Medical Center, The Zabludowicz Research Center for Autoimmune Diseases, Tel Hashomer, 5262000, IsraelCorrespondence: Aaron LernerChaim Sheba Medical Center, The Zabludowicz Research Center for Autoimmune Diseases, Tel Hashomer, 5262000, IsraelTel +972-525-919484Email aaronlerner1948@gmail.comAbstract: Activation of various isoforms of NADPH oxidase contributes to the pathogenesis of asthma at multiple levels: promoting hypercontractility, hypertrophy, and proliferation of airway smooth muscle; enabling lung influx of eosinophils via VCAM-1; and mediating allergen-induced mast cell activation. Free bilirubin, which functions physiologically within cells as a feedback inhibitor of NADPH oxidase complexes, has been shown to have a favorable impact on each of these phases of asthma pathogenesis. The spirulina chromophore phycocyanobilin (PhyCB), a homolog of bilirubin’s precursor biliverdin, can mimic the inhibitory impact of biliverdin/bilirubin on NADPH oxidase activity, and spirulina’s versatile and profound anti-inflammatory activity in rodent studies suggests that PhyCB may have potential as a clinical inhibitor of NADPH oxidase. Hence, spirulina or PhyCB-enriched spirulina extracts merit clinical evaluation in asthma. Promoting biosynthesis of glutathione and increasing the expression and activity of various antioxidant enzymes – as by supplementing with N-acetylcysteine, Phase 2 inducers (eg, lipoic acid), selenium, and zinc – may also blunt the contribution of oxidative stress to asthma pathogenesis. Nitric oxide (NO) and hydrogen sulfide (H2S) work in various ways to oppose pathogenic mechanisms in asthma; supplemental citrulline and high-dose folate may aid NO synthesis, high-dose biotin may mimic and possibly potentiate NO’s activating impact on soluble guanylate cyclase, and NAC and taurine may boost H2S synthesis. The amino acid glycine has a hyperpolarizing effect on airway smooth muscle that is bronchodilatory. Insuring optimal intracellular levels of magnesium may modestly blunt the stimulatory impact of intracellular free calcium on bronchoconstriction. Nutraceutical regimens or functional foods incorporating at least several of these agents may have utility as nutraceutical adjuvants to standard clinical management of asthma.Keywords: asthma, bronchoconstriction, calcium, NADPH oxidase, RhoA, oxidative stress

Published
2021

47. Erratum for Markmann et al., “Sex Disparities and Neutralizing-Antibody Durability to SARS-CoV-2 Infection in Convalescent Individuals”

Author

Markmann, Alena J., primary, Giallourou, Natasa, additional, Bhowmik, D. Ryan, additional, Hou, Yixuan J., additional, Lerner, Aaron, additional, Martinez, David R., additional, Premkumar, Lakshmanane, additional, Root, Heather, additional, van Duin, David, additional, Napravnik, Sonia, additional, Graham, Stephen D., additional, Guerra, Quique, additional, Raut, Rajendra, additional, Petropoulos, Christos J., additional, Wrin, Terri, additional, Cornaby, Caleb, additional, Schmitz, John, additional, Kuruc, JoAnn, additional, Weiss, Susan, additional, Park, Yara, additional, Baric, Ralph, additional, de Silva, Aravinda M., additional, Margolis, David M., additional, and Bartelt, Luther A., additional

Published
2021
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