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3. Elucidating the fundamental fibrotic processes driving abdominal adhesion formation

Author

Foster, Deshka S., Marshall, Clement D., Gulati, Gunsagar S., Chinta, Malini S., Nguyen, Alan, Salhotra, Ankit, Jones, R. Ellen, Burcham, Austin, Lerbs, Tristan, Cui, Lu, King, Megan E., Titan, Ashley L., Ransom, R. Chase, Manjunath, Anoop, Hu, Michael S., Blackshear, Charles P., Mascharak, Shamik, Moore, Alessandra L., Norton, Jeffrey A., Kin, Cindy J., Shelton, Andrew A., Januszyk, Michael, Gurtner, Geoffrey C., Wernig, Gerlinde, and Longaker, Michael T.

Published
2020
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8. Multi-Omics Profiling of Skin Biopsies of Patients with Sclerodermatous Graft-Vs-Host Disease Suggests Therapeutic Potential of Targeting Don't Eat Me Signals

Author

Cui, Lu, primary, De Souza, Cristabelle, additional, Lerbs, Tristan, additional, Poyser, Jessica, additional, Yu, Clarissa, additional, Rieger, Kerri, additional, Arai, Sally, additional, Brown, Ryanne, additional, Shizuru, Judith A, additional, Müller, Antonia Maria Susanne, additional, and Wernig, Gerlinde, additional

Published
2022
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9. Innate immune cell activation causes lung fibrosis in a humanized model of long COVID.

Author

Lu Cui, Zhuoqing Fang, Madona De Souza, Cristabelle, Lerbs, Tristan, Yuan Guan, Li, Irene, Charu, Vivek, Shih-Yu Chen, Weissman, Irving, and Wernig, Gerlinde

Subjects
POST-acute COVID-19 syndrome, PULMONARY fibrosis, COVID-19 pandemic, CD47 antigen, COVID-19
Abstract

COVID-19 remains a global pandemic of an unprecedented magnitude with millions of people now developing “COVID lung fibrosis.” Single-cell transcriptomics of lungs of patients with long COVID revealed a unique immune signature demonstrating the upregulation of key proinflammatory and innate immune effector genes CD47, IL-6, and JUN. We modeled the transition to lung fibrosis after COVID and profiled the immune response with single-cell mass cytometry in JUN mice. These studies revealed that COVID mediated chronic immune activation reminiscent to long COVID in humans. It was characterized by increased CD47, IL-6, and phospho-JUN (pJUN) expression which correlated with disease severity and pathogenic fibroblast populations. When we subsequently treated a humanized COVID lung fibrosis model by combined blockade of inflammation and fibrosis, we not only ameliorated fibrosis but also restored innate immune equilibrium indicating possible implications for clinical management of COVID lung fibrosis in patients. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Selective Targeting of Immune Modulatory Proteins to Mitigate Fibrosis and Inflammation in Sclerodermatous Graft-Vs-Host Disease

Author

Cui, Lu, primary, De Souza, Cristabelle, additional, Lerbs, Tristan, additional, Poyser, Jessica, additional, Kooshesh, Maryam, additional, Saleem, Atif, additional, Rieger, Kerri, additional, Brown, Ryanne, additional, Kwong, Bernice, additional, Fernandez-Pol, Sebastian, additional, Arai, Sally, additional, Shizuru, Judith A, additional, Mueller, Antonia MS, additional, and Wernig, Gerlinde, additional

Published
2021
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12. JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models

Author

Griffin, Michelle F., primary, Borrelli, Mimi R., additional, Garcia, Julia T., additional, Januszyk, Michael, additional, King, Megan, additional, Lerbs, Tristan, additional, Cui, Lu, additional, Moore, Alessandra L., additional, Shen, Abra H., additional, Mascharak, Shamik, additional, Diaz Deleon, Nestor M., additional, Adem, Sandeep, additional, Taylor, Walter L., additional, desJardins-Park, Heather E., additional, Gastou, Marc, additional, Patel, Ronak A., additional, Duoto, Bryan A., additional, Sokol, Jan, additional, Wei, Yuning, additional, Foster, Deshka, additional, Chen, Kellen, additional, Wan, Derrick C., additional, Gurtner, Geoffrey C., additional, Lorenz, Hermann P., additional, Chang, Howard Y., additional, Wernig, Gerlinde, additional, and Longaker, Michael T., additional

Published
2021
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13. Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors

Author

Cui, Lu, primary, Moraga, Ignacio, additional, Lerbs, Tristan, additional, Van Neste, Camille, additional, Wilmes, Stephan, additional, Tsutsumi, Naotaka, additional, Trotman-Grant, Aaron Claudius, additional, Gakovic, Milica, additional, Andrews, Sarah, additional, Gotlib, Jason, additional, Darmanis, Spyros, additional, Enge, Martin, additional, Quake, Stephen, additional, Hitchcock, Ian S., additional, Piehler, Jacob, additional, Garcia, K. Christopher, additional, and Wernig, Gerlinde, additional

Published
2020
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14. Tuning TPO-R signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia

Author

Cui, Lu, primary, Moraga, Ignacio, additional, Lerbs, Tristan, additional, Neste, Camille Van, additional, Wilmes, Stephan, additional, Tsutsumi, Naotaka, additional, Trotman-Grant, Aaron Claudius, additional, Gakovic, Milica, additional, Andrews, Sarah, additional, Gotlib, Jason, additional, Darmanis, Spyridon, additional, Enge, Martin, additional, Quake, Stephen, additional, Hitchcock, Ian S., additional, Piehler, Jacob, additional, Garcia, K. Christopher, additional, and Wernig, Gerlinde, additional

Published
2020
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16. Abstract 186

Author

Borrelli, Mimi R., primary, Garcia, Julia, additional, Griffin, Michelle, additional, Deleon Diaz, Nestor M., additional, Moore, Alexandra L., additional, Mascharak, Shamik, additional, Duoto, Bryan, additional, desJardins-Park, Heather, additional, Adem, Sandeep, additional, Lerbs, Tristan, additional, Gastou, Marc, additional, Cui, Lui, additional, Januszyk, Michael, additional, Lorenz, Hermann P., additional, Wan, Derrick C., additional, Gurtner, Geoffrey C., additional, Chang, Howard, additional, Wernig, Gerlinde, additional, and Longaker, Michael T., additional

Published
2020
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18. Additional file 3: Table 2. of Inhibition of Six1 affects tumour invasion and the expression of cancer stem cell markers in pancreatic cancer

Author

Lerbs, Tristan, Bisht, Savita, SchĂślch, Sebastian, Pecqueux, Mathieu, Kristiansen, Glen, Schneider, Martin, Hofmann, Bianca, Welsch, Thilo, Reissfelder, Christoph, Rahbari, Nuh, Fritzmann, Johannes, Brossart, Peter, JĂźrgen Weitz, Feldmann, Georg, and Kahlert, Christoph

Abstract

Six1, CD44, CD24 and tumor volumes in each mice. (DOCX 11Â kb)

Published
2017
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19. Inhibition of Six1 affects tumour invasion and the expression of cancer stem cell markers in pancreatic cancer

Author

Lerbs, Tristan, primary, Bisht, Savita, additional, Schölch, Sebastian, additional, Pecqueux, Mathieu, additional, Kristiansen, Glen, additional, Schneider, Martin, additional, Hofmann, Bianca T., additional, Welsch, Thilo, additional, Reissfelder, Christoph, additional, Rahbari, Nuh N., additional, Fritzmann, Johannes, additional, Brossart, Peter, additional, Weitz, Jürgen, additional, Feldmann, Georg, additional, and Kahlert, Christoph, additional

Published
2017
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20. Additional file 1: Table 1. of Inhibition of Six1 affects tumour invasion and the expression of cancer stem cell markers in pancreatic cancer

Author

Lerbs, Tristan, Bisht, Savita, SchĂślch, Sebastian, Pecqueux, Mathieu, Kristiansen, Glen, Schneider, Martin, Hofmann, Bianca, Welsch, Thilo, Reissfelder, Christoph, Rahbari, Nuh, Fritzmann, Johannes, Brossart, Peter, JĂźrgen Weitz, Feldmann, Georg, and Kahlert, Christoph

Subjects
3. Good health
Abstract

Six1 expression in the cell nucleus of malignant and benign tissue and its correlation to clinical and histopathological parameters. *Only 135 malignant and 103 benign specimens could be included. **Only 136 malignant specimens could be evaluated. (DOCX 14Â kb)

21. Additional file 1: Table 1. of Inhibition of Six1 affects tumour invasion and the expression of cancer stem cell markers in pancreatic cancer

Author

Lerbs, Tristan, Bisht, Savita, SchĂślch, Sebastian, Pecqueux, Mathieu, Kristiansen, Glen, Schneider, Martin, Hofmann, Bianca, Welsch, Thilo, Reissfelder, Christoph, Rahbari, Nuh, Fritzmann, Johannes, Brossart, Peter, JĂźrgen Weitz, Feldmann, Georg, and Kahlert, Christoph

Subjects
3. Good health
Abstract

Six1 expression in the cell nucleus of malignant and benign tissue and its correlation to clinical and histopathological parameters. *Only 135 malignant and 103 benign specimens could be included. **Only 136 malignant specimens could be evaluated. (DOCX 14Â kb)

22. Additional file 2: Fig. S1. of Inhibition of Six1 affects tumour invasion and the expression of cancer stem cell markers in pancreatic cancer

Author

Lerbs, Tristan, Bisht, Savita, SchĂślch, Sebastian, Pecqueux, Mathieu, Kristiansen, Glen, Schneider, Martin, Hofmann, Bianca, Welsch, Thilo, Reissfelder, Christoph, Rahbari, Nuh, Fritzmann, Johannes, Brossart, Peter, JĂźrgen Weitz, Feldmann, Georg, and Kahlert, Christoph

Subjects
3. Good health
Abstract

Sequence of siRNA against Six1R1. (PPTX 3958Â kb)

23. Additional file 3: Table 2. of Inhibition of Six1 affects tumour invasion and the expression of cancer stem cell markers in pancreatic cancer

Author

Lerbs, Tristan, Bisht, Savita, SchĂślch, Sebastian, Pecqueux, Mathieu, Kristiansen, Glen, Schneider, Martin, Hofmann, Bianca, Welsch, Thilo, Reissfelder, Christoph, Rahbari, Nuh, Fritzmann, Johannes, Brossart, Peter, JĂźrgen Weitz, Feldmann, Georg, and Kahlert, Christoph

Subjects
3. Good health
Abstract

Six1, CD44, CD24 and tumor volumes in each mice. (DOCX 11Â kb)

24. Additional file 2: Fig. S1. of Inhibition of Six1 affects tumour invasion and the expression of cancer stem cell markers in pancreatic cancer

Author

Lerbs, Tristan, Bisht, Savita, SchĂślch, Sebastian, Pecqueux, Mathieu, Kristiansen, Glen, Schneider, Martin, Hofmann, Bianca, Welsch, Thilo, Reissfelder, Christoph, Rahbari, Nuh, Fritzmann, Johannes, Brossart, Peter, JĂźrgen Weitz, Feldmann, Georg, and Kahlert, Christoph

Subjects
3. Good health
Abstract

Sequence of siRNA against Six1R1. (PPTX 3958Â kb)

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