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Author

Lepping, Peter, Bewley, Anthony, editor, Lepping, Peter, editor, and Taylor, Ruth, editor

Published
2021
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10. Efficacy of antipsychotics in delusional infestation.

Author

Tang, Paul K., Lepping, Peter, Lepping, Sophie G., Noorthoorn, Eric O., Squire, Stephen B., Mohandas, Padma, and Bewley, Anthony

Abstract

Background Objectives Methods Results Conclusions Data remain scarce for the first‐line antipsychotic choice in treating delusional infestation (DI).We evaluated the treatment responses associated with different antipsychotics in DI patients.We undertook a multicentre, retrospective observational study using anonymised electronic patient records from two hospitals in the United Kingdom from 1 January 2011 to 1 January 2023. Eligible participants were adults (≥18 years) diagnosed with DI treated with an antipsychotic, and had both an assigned baseline and follow‐up Clinical Global Impression Scale (CGI‐S) score. The CGI‐S is a validated psychiatric research tool. Participants were excluded if they had known limited or non‐adherence to an antipsychotic, or if no CGI‐S scores were present at follow‐up. First clinic visits before the initiation of an antipsychotic were assigned as the baseline CGI‐S score. The last available CGI‐S score before the patient either changed antipsychotic or left the clinic for any reason was used to assign follow‐up CGI‐S scores. The primary outcome was the response to each individual antipsychotic treatment, measured by the difference in the baseline and last available follow‐up CGI‐S scores. Differences in CGI‐S changes between antipsychotic episodes were tested by analysis of variance (ANOVA).In total, 414 patient records were analysed, and data were extracted. The mean age was 61.8 years (SD 14.1). One hundred seventy (41%) of 414 patients were men and 244 (59%) were women. In total, 156 (38%) of 414 patients were eligible, yielding a total of 315 antipsychotic prescribing episodes. The ANOVA, ranking in order of treatment response, showed that the highest mean score (expressing highest treatment response) was observed in amisulpride (31 [67%] of 46) and risperidone (95 [57%] of 167), followed by some distance by quetiapine (9 [36%] of 25), aripiprazole (13 [28%] of 46) and olanzapine (7 [25%] of 28).Amisulpride and risperidone were associated with a higher treatment response than quetiapine, aripiprazole and olanzapine. Amisulpride and risperidone should therefore be considered the first‐line treatment options in DI patients. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Risk Factors for Nonattendance in Delusional Infestation: A Multicenter Observational Study:A Multicenter Observational Study

Author

Kemperman, Patrick, Wennekers, Mèdelyn, Lepping, Peter, Bewley, Anthony, Aboalkaz, Sara, Kazmi, Ahmed, Waalboer-Spuij, Rick, Kemperman, Patrick, Wennekers, Mèdelyn, Lepping, Peter, Bewley, Anthony, Aboalkaz, Sara, Kazmi, Ahmed, and Waalboer-Spuij, Rick

Abstract

Background: Nonattendance is common among patients suffering from delusional infestation (DI) with a risk factor for poorer patient outcomes. Objective: The aim of this study was to determine the incidence rate and predictors of nonattendance among patients presenting to a psychodermatology department with DI and the subsequent effect on the success of prescribing new antipsychotics. Methods: Data of 265 patients were reviewed of the Amsterdam UMC, the Erasmus University Medical Center, the Royal London Hospital, and the Liverpool School of Tropical Medicine between January 2008 and October 2019. Results: We observed that among the patients who attended the first consultation, 57% (n = 144) did not attend their second visit. Recreational drug use was significantly higher in the nonattendance group compared to the attendance group (25% against 18%). Patients who had a history of previously prescribed antipsychotics at the time of the first consultation were less likely to get prescribed antipsychotics from the psychodermatology departments for DI; however, prescribing antipsychotic drugs by the psychodermatology department did not influence nonattendance significantly. Conclusions: People suffering from DI are at high risk of nonattendance, even in specialist settings. Patients with current illicit drug use and younger patients are particularly at risk of this.

Published
2023

22. Risk Factors for Nonattendance in Delusional Infestation: A Multicenter Observational Study: A Multicenter Observational Study

Author

Kemperman, Patrick, Wennekers, Mèdelyn, Lepping, Peter, Bewley, Anthony, Aboalkaz, Sara, Kazmi, Ahmed, Waalboer-Spuij, Rick, and Dermatology

Abstract

Background: Nonattendance is common among patients suffering from delusional infestation (DI) with a risk factor for poorer patient outcomes. Objective: The aim of this study was to determine the incidence rate and predictors of nonattendance among patients presenting to a psychodermatology department with DI and the subsequent effect on the success of prescribing new antipsychotics. Methods: Data of 265 patients were reviewed of the Amsterdam UMC, the Erasmus University Medical Center, the Royal London Hospital, and the Liverpool School of Tropical Medicine between January 2008 and October 2019. Results: We observed that among the patients who attended the first consultation, 57% (n = 144) did not attend their second visit. Recreational drug use was significantly higher in the nonattendance group compared to the attendance group (25% against 18%). Patients who had a history of previously prescribed antipsychotics at the time of the first consultation were less likely to get prescribed antipsychotics from the psychodermatology departments for DI; however, prescribing antipsychotic drugs by the psychodermatology department did not influence nonattendance significantly. Conclusions: People suffering from DI are at high risk of nonattendance, even in specialist settings. Patients with current illicit drug use and younger patients are particularly at risk of this.

Published
2023

32. Menopause and mental health.

Author

Swaminathan, Ajay, Lepping, Peter, and Kumar, Geeta

Subjects
*EDUCATION of physicians, *MENTAL illness risk factors, *MENTAL depression risk factors, *ALZHEIMER'S disease risk factors, *ANTIDEPRESSANTS, *HORMONE therapy, *MENTAL health, *CONTINUING education units, *RISK assessment, *SLEEP disorders, *COGNITIVE aging, *MELATONIN, *TERMS & phrases, *HEALTH behavior, *MENOPAUSE, *ANXIETY, *ALTERNATIVE medicine, *PSYCHOTHERAPY, *BEHAVIOR modification, *DISEASE risk factors
Abstract

Key content: Studies reveal a high prevalence of mental health issues around the menopause transition.Menopausal symptoms are influenced by personal and environmental factors.Beneficial effects of estrogen for menopausal depression have been reported.An integrated care model for the management of mental health symptoms is recommended.Evidence‐based management options include considering the impact of lifestyle changes, hormone replacement therapy (HRT) and cognitive behavioural therapy. Learning objectives: To understand the assessment and management of mental health issues in menopauseTo understand the role of lifestyle modifications, HRT and alternatives to HRT in the management of menopause‐related mental health issues [ABSTRACT FROM AUTHOR]

Published
2023
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50. Prevalence, New Incidence, Course, and Risk Factors of PTSD, Depression, Anxiety, and Panic Disorder during the Covid-19 Pandemic in 11 Countries

Author

Georgieva, Irina, primary, Lepping, Peter, additional, Bozev, Vasil, additional, Lickiewicz, Jakub, additional, Pekara, Jaroslav, additional, Wikman, Sofia, additional, Loseviča, Marina, additional, Raveesh, Bevinahalli Nanjegowda, additional, Mihai, Adriana, additional, and Lantta, Tella, additional

Published
2021
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