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1. Parietal intrahemispheric source connectivity of resting-state electroencephalographic alpha rhythms is abnormal in Naïve HIV patients

Author

Babiloni, Claudio, Del Percio, Claudio, Lizio, Roberta, Lopez, Susanna, Pennica, Alfredo, Roma, Paolo, Correr, Valentina, Cucciolla, Federica, Toma, Ginevra, Soricelli, Andrea, Di Campli, Francesco, Aceti, Antonio, Teti, Elisabetta, Sarmati, Loredana, Crocetti, Gloria, Ferri, Raffaele, Lorenzo, Ivan, Galli, Massimo, Negri, Cristina, Angarano, Gioacchino, Saracino, Annalisa, Lepore, Luciana, Di Pietro, Massimo, Fusco, Francesco Maria, Vullo, Vincenzo, D’Ettorre, Gabriella, Pagliano, Pasquale, Di Flumeri, Giusy, Celesia, Benedetto Maurizio, Gentilini Cacciola, Elio, Di Perri, Giovanni, Calcagno, Andrea, Stocchi, Fabrizio, Ferracuti, Stefano, Onorati, Paolo, Andreoni, Massimo, and Noce, Giuseppe

Published
2022
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2. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Abbonizio, Maria Alessandra, Abdeddaim, Amina, Agostini, Elisabetta, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antinori, Andrea, Antonica, Maria Assunta, Antonini, Mario, Bartoli, Tommaso Ascoli, Baldini, Francesco, Barbaro, Raffaella, Bartolini, Barbara, Bellagamba, Rita, Benigni, Martina, Bevilacqua, Nazario, Biava, Gianluigi, Bibas, Michele, Bordi, Licia, Bordoni, Veronica, Boumis, Evangelo, Branca, Marta, Buonomo, Rosanna, Busso, Donatella, Camici, Marta, Campioni, Paolo, Canichella, Flaminia, Capobianchi, Maria Rosaria, Capone, Alessandro, Caporale, Cinzia, Caraffa, Emanuela, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Cataldo, Adriana, Cerilli, Stefano, Cerva, Carlotta, Chiappini, Roberta, Chinello, Pierangelo, Cianfarani, Maria Assunta, Ciaralli, Carmine, Cimaglia, Claudia, Cinicola, Nicola, Ciotti, Veronica, Cicalini, Stefania, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, De Palo, Maria Grazia, De Zottis, Federico, Di Bari, Virginia, Di Lorenzo, Rachele, Di Stefano, Federica, D’Offizi, Gianpiero, Donno, Davide, Evangelista, Francesca, Faraglia, Francesca, Farina, Anna, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Fusetti, Matteo, Galati, Vincenzo, Gagliardini, Roberta, Gallì, Paola, Garotto, Gabriele, Gaviano, Ilaria, Tekle, Saba Gebremeskel, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Granata, Guido, Greci, Maria Cristina, Grilli, Elisabetta, Grisetti, Susanna, Gualano, Gina, Iacomi, Fabio, Iaconi, Marta, Iannicelli, Giuseppina, Inversi, Carlo, Ippolito, Giuseppe, Lalle, Eleonora, Lamanna, Maria Elena, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Libertone, Raffaella, Lionetti, Raffaella, Liuzzi, Giuseppina, Loiacono, Laura, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Maffongelli, Gaetano, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Mastrobattista, Annelisa, Mastrorosa, Ilaria, Matusali, Giulia, Mazzotta, Valentina, Mencarini, Paola, Meschi, Silvia, Messina, Francesco, Micarelli, Sibiana, Mogavero, Giulia, Mondi, Annalisa, Montalbano, Marzia, Montaldo, Chiara, Mosti, Silvia, Murachelli, Silvia, Musso, Maria, Nardi, Michela, Navarra, Assunta, Nicastri, Emanuele, Nocioni, Martina, Noto, Pasquale, Noto, Roberto, Oliva, Alessandra, Onnis, Ilaria, Ottou, Sandrine, Palazzolo, Claudia, Pallini, Emanuele, Palmieri, Fabrizio, Palombi, Giulio, Pareo, Carlo, Passeri, Virgilio, Pelliccioni, Federico, Penna, Giovanna, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pinnetti, Carmela, Pisciotta, Maria, Piselli, Pierluca, Pittalis, Silvia, Pontarelli, Agostina, Proietti, Costanza, Puro, Vincenzo, Ramazzini, Paolo Migliorisi, Rianda, Alessia, Rinonapoli, Gabriele, Rosati, Silvia, Rubino, Dorotea, Rueca, Martina, Ruggeri, Alberto, Sacchi, Alessandra, Sampaolesi, Alessandro, Sanasi, Francesco, Santagata, Carmen, Scarabello, Alessandra, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Strano, Giacomo, Taglietti, Fabrizio, Taibi, Chiara, Taloni, Giorgia, Nardi, Tetaj, Tonnarini, Roberto, Topino, Simone, Tozzi, Martina, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Vergori, Alessandra, Vincenzi, Laura, Visco-Comandini, Ubaldo, Vita, Serena, Vittozzi, Pietro, Zaccarelli, Mauro, Zanetti, Antonella, Zito, Sara, Lorenzini, Patrizia, Di Gennaro, Francesco, and Girardi, Enrico

Published
2021
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3. 2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation

Author

Abbonizio, Maria Alessandra, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Chiappini, Roberta, Ciaralli, Carmine, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, Angelis, Alessia De, Angelis, Giada De, Lorenzo, Rachele Di, Stefano, Federica Di, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Greci, Maria Cristina, Ippolito, Giuseppe, Lalle, Eleonora, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Montaldo, Francesco Messina Chiara, Murachelli, Silvia, Nicastri, Emanuele, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Di Stefano, Federica, Eskild, Petersen, and Zumla, Alimuddin

Published
2020
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5. A whole blood test to measure SARS-CoV-2-specific response in COVID-19 patients

Author

Petrone, Linda, Petruccioli, Elisa, Vanini, Valentina, Cuzzi, Gilda, Najafi Fard, Saeid, Alonzi, Tonino, Castilletti, Concetta, Palmieri, Fabrizio, Gualano, Gina, Vittozzi, Pietro, Nicastri, Emanuele, Lepore, Luciana, Antinori, Andrea, Vergori, Alessandra, Caccamo, Nadia, Cantini, Fabrizio, Girardi, Enrico, Ippolito, Giuseppe, Grifoni, Alba, and Goletti, Delia

Published
2021
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6. Prevalence of Chagas disease and strongyloidiasis among HIV-infected Latin American immigrants in Italy – The CHILI study

Author

Rodari, Paola, primary, Tamarozzi, Francesca, additional, Tais, Stefano, additional, Degani, Monica, additional, Perandin, Francesca, additional, Buonfrate, Dora, additional, Nicastri, Emanuele, additional, Lepore, Luciana, additional, Giancola, Maria Letizia, additional, Carrara, Stefania, additional, Tavelli, Alessandro, additional, Cozzi-Lepri, Alessandro, additional, D'Arminio Monforte, Antonella, additional, Silva, Ronaldo, additional, and Angheben, Andrea, additional

Published
2022
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7. Additional file 2 of Systematic analysis of direct antiglobulin test results in post-artesunate delayed haemolysis

Author

Bartoli, Tommaso Ascoli, Lepore, Luciana, D’Abramo, Alessandra, Adamo, Giovanna, Corpolongo, Angela, Scorzolini, Laura, Giancola, Maria Letizia, Bevilacqua, Nazario, Palazzolo, Claudia, Mariano, Andrea, Ippolito, Giuseppe, Buffet, Pierre, and Nicastri, Emanuele

Abstract

Additional file 2. Epidemiological, clinical, and therapeutic characteristics of patients with PADH with an available DAT result reported as aggregate case series and stratified according to the administration of systemic steroids.

Published
2021
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8. In-vitro evaluation of the immunomodulatory effects of Baricitinib: Implication for COVID-19 therapy

Author

Petrone, Linda, primary, Petruccioli, Elisa, additional, Alonzi, Tonino, additional, Vanini, Valentina, additional, Cuzzi, Gilda, additional, Najafi Fard, Saeid, additional, Castilletti, Concetta, additional, Palmieri, Fabrizio, additional, Gualano, Gina, additional, Vittozzi, Pietro, additional, Nicastri, Emanuele, additional, Lepore, Luciana, additional, Grifoni, Alba, additional, Antinori, Andrea, additional, Vergori, Alessandra, additional, Ippolito, Giuseppe, additional, Cantini, Fabrizio, additional, and Goletti, Delia, additional

Published
2021
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9. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Mondi, Annalisa, primary, Lorenzini, Patrizia, additional, Castilletti, Concetta, additional, Gagliardini, Roberta, additional, Lalle, Eleonora, additional, Corpolongo, Angela, additional, Valli, Maria Beatrice, additional, Taglietti, Fabrizio, additional, Cicalini, Stefania, additional, Loiacono, Laura, additional, Di Gennaro, Francesco, additional, D’Offizi, Gianpiero, additional, Palmieri, Fabrizio, additional, Nicastri, Emanuele, additional, Agrati, Chiara, additional, Petrosillo, Nicola, additional, Ippolito, Giuseppe, additional, Vaia, Francesco, additional, Girardi, Enrico, additional, Capobianchi, Maria Rosaria, additional, Antinori, Andrea, additional, Zito, Sara, additional, Abbonizio, Maria Alessandra, additional, Abdeddaim, Amina, additional, Agostini, Elisabetta, additional, Albarello, Fabrizio, additional, Amadei, Gioia, additional, Amendola, Alessandra, additional, Antonica, Maria Assunta, additional, Antonini, Mario, additional, Bartoli, Tommaso Ascoli, additional, Baldini, Francesco, additional, Barbaro, Raffaella, additional, Bartolini, Barbara, additional, Bellagamba, Rita, additional, Benigni, Martina, additional, Bevilacqua, Nazario, additional, Biava, Gianluigi, additional, Bibas, Michele, additional, Bordi, Licia, additional, Bordoni, Veronica, additional, Boumis, Evangelo, additional, Branca, Marta, additional, Buonomo, Rosanna, additional, Busso, Donatella, additional, Camici, Marta, additional, Campioni, Paolo, additional, Canichella, Flaminia, additional, Capone, Alessandro, additional, Caporale, Cinzia, additional, Caraffa, Emanuela, additional, Caravella, Ilaria, additional, Carletti, Fabrizio, additional, Cataldo, Adriana, additional, Cerilli, Stefano, additional, Cerva, Carlotta, additional, Chiappini, Roberta, additional, Chinello, Pierangelo, additional, Cianfarani, Maria Assunta, additional, Ciaralli, Carmine, additional, Cimaglia, Claudia, additional, Cinicola, Nicola, additional, Ciotti, Veronica, additional, Colavita, Francesca, additional, Cristofaro, Massimo, additional, Curiale, Salvatore, additional, D’Abramo, Alessandra, additional, Dantimi, Cristina, additional, De Angelis, Alessia, additional, De Angelis, Giada, additional, De Palo, Maria Grazia, additional, De Zottis, Federico, additional, Di Bari, Virginia, additional, Di Lorenzo, Rachele, additional, Di Stefano, Federica, additional, Donno, Davide, additional, Evangelista, Francesca, additional, Faraglia, Francesca, additional, Farina, Anna, additional, Ferraro, Federica, additional, Fiorentini, Lorena, additional, Frustaci, Andrea, additional, Fusetti, Matteo, additional, Galati, Vincenzo, additional, Gallì, Paola, additional, Garotto, Gabriele, additional, Gaviano, Ilaria, additional, Tekle, Saba Gebremeskel, additional, Giancola, Maria Letizia, additional, Giansante, Filippo, additional, Giombini, Emanuela, additional, Granata, Guido, additional, Greci, Maria Cristina, additional, Grilli, Elisabetta, additional, Grisetti, Susanna, additional, Gualano, Gina, additional, Iacomi, Fabio, additional, Iaconi, Marta, additional, Iannicelli, Giuseppina, additional, Inversi, Carlo, additional, Lamanna, Maria Elena, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Lepore, Luciana, additional, Libertone, Raffaella, additional, Lionetti, Raffaella, additional, Liuzzi, Giuseppina, additional, Lucia, Andrea, additional, Lufrani, Franco, additional, Macchione, Manuela, additional, Maffongelli, Gaetano, additional, Marani, Alessandra, additional, Marchioni, Luisa, additional, Mariano, Andrea, additional, Marini, Maria Cristina, additional, Maritti, Micaela, additional, Mastrobattista, Annelisa, additional, Mastrorosa, Ilaria, additional, Matusali, Giulia, additional, Mazzotta, Valentina, additional, Mencarini, Paola, additional, Meschi, Silvia, additional, Messina, Francesco, additional, Micarelli, Sibiana, additional, Mogavero, Giulia, additional, Mondi, Annalisa, additional, Montalbano, Marzia, additional, Montaldo, Chiara, additional, Mosti, Silvia, additional, Murachelli, Silvia, additional, Musso, Maria, additional, Nardi, Michela, additional, Navarra, Assunta, additional, Nocioni, Martina, additional, Noto, Pasquale, additional, Noto, Roberto, additional, Oliva, Alessandra, additional, Onnis, Ilaria, additional, Ottou, Sandrine, additional, Palazzolo, Claudia, additional, Pallini, Emanuele, additional, Palombi, Giulio, additional, Pareo, Carlo, additional, Passeri, Virgilio, additional, Pelliccioni, Federico, additional, Penna, Giovanna, additional, Petrecchia, Antonella, additional, Petrone, Ada, additional, Pianura, Elisa, additional, Pinnetti, Carmela, additional, Pisciotta, Maria, additional, Piselli, Pierluca, additional, Pittalis, Silvia, additional, Pontarelli, Agostina, additional, Proietti, Costanza, additional, Puro, Vincenzo, additional, Ramazzini, Paolo Migliorisi, additional, Rianda, Alessia, additional, Rinonapoli, Gabriele, additional, Rosati, Silvia, additional, Rubino, Dorotea, additional, Rueca, Martina, additional, Ruggeri, Alberto, additional, Sacchi, Alessandra, additional, Sampaolesi, Alessandro, additional, Sanasi, Francesco, additional, Santagata, Carmen, additional, Scarabello, Alessandra, additional, Scarcia, Silvana, additional, Schininà, Vincenzo, additional, Scognamiglio, Paola, additional, Scorzolini, Laura, additional, Stazi, Giulia, additional, Strano, Giacomo, additional, Taibi, Chiara, additional, Taloni, Giorgia, additional, Nardi, Tetaj, additional, Tonnarini, Roberto, additional, Topino, Simone, additional, Tozzi, Martina, additional, Vairo, Francesco, additional, Vergori, Alessandra, additional, Vincenzi, Laura, additional, Visco-Comandini, Ubaldo, additional, Vita, Serena, additional, Vittozzi, Pietro, additional, Zaccarelli, Mauro, additional, and Zanetti, Antonella, additional

Published
2021
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10. Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19

Author

Tempestilli, Massimo, Caputi, Priscilla, Avataneo, Valeria, Notari, Stefania, Forini, Olindo, Scorzolini, Laura, Marchioni, Luisa, Ascoli Bartoli, Tommaso, Castilletti, Concetta, Lalle, Eleonora, Capobianchi, Maria R, Nicastri, Emanuele, D’Avolio, Antonio, Ippolito, Giuseppe, Agrati, Chiara, Abbonizio, Maria Alessandra, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antinori, Andrea, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Casetti, Rita, Chiappini, Roberta, Ciaralli, Carmine, Cimini, Eleonora, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, Di Lorenzo, Rachele, Di Stefano, Federica, D’Offizi, Gianpiero, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Grassi, Germana, Greci, Maria Cristina, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Messina, Francesco, Montaldo, Chiara, Murachelli, Silvia, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Palmieri, Fabrizio, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, and Valli, Maria Beatrice

Subjects
0301 basic medicine, Drug, Male, Microbiology (medical), medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), COVID19, media_common.quotation_subject, Critical Illness, 030106 microbiology, Pneumonia, Viral, remdesivir, Loading dose, Gastroenterology, Antiviral Agents, NO, 03 medical and health sciences, Betacoronavirus, Adenosine Triphosphate, Pharmacokinetics, Internal medicine, medicine, Humans, Pharmacology (medical), Pandemics, media_common, EC50, Original Research, Aged, Pharmacology, Lung, Alanine, Nucleoside analogue, business.industry, SARS-CoV-2, COVID-19, Recovery of Function, Prodrug, Adenosine Monophosphate, 030104 developmental biology, medicine.anatomical_structure, Infectious Diseases, Pharmacokinetics, COVID19, remdesivir, Female, business, Coronavirus Infections, medicine.drug
Abstract

Background Remdesivir is a prodrug of the nucleoside analogue GS-441524 and is under evaluation for treatment of SARS-CoV-2-infected patients. Objectives To evaluate the pharmacokinetics of remdesivir and GS-441524 in plasma, bronchoalveolar aspirate (BAS) and CSF in two critically ill COVID-19 patients. Methods Remdesivir was administered at 200 mg loading dose on the first day followed by 12 days of 100 mg in two critically ill patients. Blood samples were collected immediately after (C0) and at 1 (C1) and 24 h (C24) after intravenous administration on day 3 until day 9. BAS samples were collected on Days 4, 7 and 9 from both patients while one CSF on Day 7 was obtained in one patient. Remdesivir and GS-441524 concentrations were measured in these samples using a validated UHPLC-MS/MS method. Results We observed higher concentrations of remdesivir at C0 (6- to 7-fold higher than EC50 from in vitro studies) and a notable decay at C1. GS-441524 plasma concentrations reached a peak at C1 and persisted until the next administration. Higher concentrations of GS-441524 were observed in the patient with mild renal dysfunction. Mean BAS/plasma concentration ratios of GS-441524 were 2.3% and 6.4% in Patient 1 and Patient 2, respectively. The CSF concentration found in Patient 2 was 25.7% with respect to plasma. GS-441524 levels in lung and CNS suggest compartmental differences in drug exposure. Conclusions We report the first pharmacokinetic evaluation of remdesivir and GS-441524 in recovered COVID-19 patients. Further study of the pharmacokinetic profile of remdesivir, GS-441524 and the intracellular triphosphate form are required.

Published
2020
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11. Long-term maintenance of virologic suppression in native and migrant HIV-1 naïve patients: an Italian cohort study

Author

Lagi, Filippo, primary, Kiros, Seble Tekle, additional, Di Giambenedetto, Simona, additional, Lombardi, Francesca, additional, Pecorari, Monica, additional, Borghi, Vanni, additional, Lepore, Luciana, additional, Monno, Laura, additional, Setti, Maurizio, additional, Micheli, Valeria, additional, Bagnarelli, Patrizia, additional, Paolini, Elisabetta, additional, Bai, Francesca, additional, Bartoloni, Alessandro, additional, and Sterrantino, Gaetana, additional

Published
2020
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12. Systematic Analysis of Direct Antiglobulin Test Results in Post-artesunate Delayed Hemolysis

Author

Bartoli, Tommaso Ascoli, primary, Lepore, Luciana, additional, D'Abramo, Alessandra, additional, Adamo, Giovanna, additional, Corpolongo, Angela, additional, Scorzolini, Laura, additional, Giancola, Maria Letizia, additional, Bevilacqua, Nazario, additional, Palazzolo, Claudia, additional, Mariano, Andrea, additional, Ippolito, Giuseppe, additional, Buffet, Pierre, additional, and Nicastri, Emanuele, additional

Published
2020
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13. Authors’ response: importance of a careful investigation to avoid attributing Legionnaires’ disease cases to an incorrect source of infection

Author

Palazzolo, Claudia, primary, Maffongelli, Gaetano, additional, D’Abramo, Alessandra, additional, Lepore, Luciana, additional, Mariano, Andrea, additional, Vulcano, Antonella, additional, Bartoli, Tommaso Ascoli, additional, Bevilacqua, Nazario, additional, Giancola, Maria Letizia, additional, Di Rosa, Enrico, additional, and Nicastri, Emanuele, additional

Published
2020
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15. Legionella pneumonia: increased risk after COVID-19 lockdown? Italy, May to June 2020

Author

Palazzolo, Claudia, primary, Maffongelli, Gaetano, additional, D’Abramo, Alessandra, additional, Lepore, Luciana, additional, Mariano, Andrea, additional, Vulcano, Antonella, additional, Bartoli, Tommaso Ascoli, additional, Bevilacqua, Nazario, additional, Giancola, Maria Letizia, additional, Di Rosa, Enrico, additional, and Nicastri, Emanuele, additional

Published
2020
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16. 2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation

Author

Albarello, Fabrizio, primary, Pianura, Elisa, additional, Di Stefano, Federica, additional, Cristofaro, Massimo, additional, Petrone, Ada, additional, Marchioni, Luisa, additional, Palazzolo, Claudia, additional, Schininà, Vincenzo, additional, Nicastri, Emanuele, additional, Petrosillo, Nicola, additional, Campioni, Paolo, additional, Eskild, Petersen, additional, Zumla, Alimuddin, additional, Ippolito, Giuseppe, additional, Abbonizio, Maria Alessandra, additional, Agrati, Chiara, additional, Albarello, Fabrizio, additional, Amadei, Gioia, additional, Amendola, Alessandra, additional, Antonini, Mario, additional, Barbaro, Raffaella, additional, Bartolini, Barbara, additional, Benigni, Martina, additional, Bevilacqua, Nazario, additional, Bordi, Licia, additional, Bordoni, Veronica, additional, Branca, Marta, additional, Capobianchi, Maria Rosaria, additional, Caporale, Cinzia, additional, Caravella, Ilaria, additional, Carletti, Fabrizio, additional, Castilletti, Concetta, additional, Chiappini, Roberta, additional, Ciaralli, Carmine, additional, Colavita, Francesca, additional, Corpolongo, Angela, additional, Curiale, Salvatore, additional, D’Abramo, Alessandra, additional, Dantimi, Cristina, additional, Angelis, Alessia De, additional, Angelis, Giada De, additional, Lorenzo, Rachele Di, additional, Stefano, Federica Di, additional, Ferraro, Federica, additional, Fiorentini, Lorena, additional, Frustaci, Andrea, additional, Gallì, Paola, additional, Garotto, Gabriele, additional, Giancola, Maria Letizia, additional, Giansante, Filippo, additional, Giombini, Emanuela, additional, Greci, Maria Cristina, additional, Lalle, Eleonora, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Lepore, Luciana, additional, Lucia, Andrea, additional, Lufrani, Franco, additional, Macchione, Manuela, additional, Marani, Alessandra, additional, Mariano, Andrea, additional, Marini, Maria Cristina, additional, Maritti, Micaela, additional, Matusali, Giulia, additional, Meschi, Silvia, additional, Montaldo, Francesco Messina Chiara, additional, Murachelli, Silvia, additional, Noto, Roberto, additional, Pallini, Emanuele, additional, Passeri, Virgilio, additional, Pelliccioni, Federico, additional, Petrecchia, Antonella, additional, Pisciotta, Maria, additional, Pittalis, Silvia, additional, Proietti, Costanza, additional, Puro, Vincenzo, additional, Rinonapoli, Gabriele, additional, Rueca, Martina, additional, Sacchi, Alessandra, additional, Sanasi, Francesco, additional, Santagata, Carmen, additional, Scarcia, Silvana, additional, Scognamiglio, Paola, additional, Scorzolini, Laura, additional, Stazi, Giulia, additional, Vaia, Francesco, additional, Vairo, Francesco, additional, and Valli, Maria Beatrice, additional

Published
2020
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18. National Institute for the Infectious Diseases “L. Spallanzani” IRCCS. Recommendations for COVID-19 Clinical Management

Author

Nicastri, Emanuele, primary, Petrosillo, Nicola, additional, Ascoli Bartoli, Tommaso, additional, Lepore, Luciana, additional, Mondi, Annalisa, additional, Palmieri, Fabrizio, additional, D’Offizi, Gianpiero, additional, Marchioni, Luisa, additional, Murachelli, Silvia, additional, Ippolito, Giuseppe, additional, and Antinori for ICOTREG, Andrea, additional

Published
2020
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19. The Evolution of Clinical and Scientific Evidence-Based Management Guidelines for COVID-19 Disease: A Longitudinal Descriptive Analysis

Author

Nicastri, Emanuele, primary, D’Abramo, Alessandra, additional, Lepore, Luciana, additional, Maffongelli, Gaetano, additional, Bartoli, Tommaso Ascoli, additional, Vita, Serena, additional, Montaldo, Chiara, additional, Locatelli, Franco, additional, Zumla, Alimuddin, additional, and Ippolito, Giuseppe, additional

Published
2020
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20. No impact of previous NRTIs resistance in HIV positive patients switched to DTG+2NRTIs under virological control: Time of viral suppression makes the difference.

Author

Giacomelli, Andrea, primary, Lai, Alessia, additional, Franzetti, Marco, additional, Maggiolo, Franco, additional, Di Giambenedetto, Simona, additional, Borghi, Vanni, additional, Francisci, Daniela, additional, Magnani, Giacomo, additional, Pecorari, Monica, additional, Monno, Laura, additional, Vicenti, Ilaria, additional, Lepore, Luciana, additional, Lombardi, Francesca, additional, Paolucci, Stefania, additional, and Rusconi, Stefano, additional

Published
2019
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21. No impact of previous NRTIs resistance in HIV positive patients switched to DTG+2NRTIs under virological control: Time of viral suppression makes the difference

Author

Giacomelli, Andrea, Lai, Alessia, Franzetti, Marco, Maggiolo, Franco, Di Giambenedetto, Simona, Borghi, Vanni, Francisci, Daniela, Magnani, Giacomo, Pecorari, Monica, Monno, Laura, Vicenti, Ilaria, Lepore, Luciana, Lombardi, Francesca, Paolucci, Stefania, Rusconi, Stefano, Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076), Lombardi, Francesca (ORCID:0000-0001-5757-8346), Giacomelli, Andrea, Lai, Alessia, Franzetti, Marco, Maggiolo, Franco, Di Giambenedetto, Simona, Borghi, Vanni, Francisci, Daniela, Magnani, Giacomo, Pecorari, Monica, Monno, Laura, Vicenti, Ilaria, Lepore, Luciana, Lombardi, Francesca, Paolucci, Stefania, Rusconi, Stefano, Di Giambenedetto, Simona (ORCID:0000-0001-6990-5076), and Lombardi, Francesca (ORCID:0000-0001-5757-8346)

Abstract

The accumulation of drug-resistance mutations on combined antiretroviral regimens (ART) backbone could affect the virological efficacy of the regimen. Our aim was to assess the impact of previous drug resistance to nucleoside reverse transcriptase inhibitors (NRTIs) on the probability of virological failure (VF) in patients, under virological control, who switched to dolutegravir (DTG)+2NRTIs regimens. All HIV-1 positive drug-experienced patients who started a regimen composed by DTG+2NRTIs [abacavir/lamivudine or tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide (TAF)/emtricitabine (FTC)] in the ARCA collaborative group with HIV-RNA <50 cp/mL were included in the analysis. Patients with a previous VF to integrase inhibitors were excluded. The impact of single and combined NRTIs mutations on the probability of VF (defined as 2 consecutive HIV-RNA >50 copies/mL or one HIV-RNA >1000 copies/mL) was assessed by Kaplan Meier curves. A multivariable Cox regression analysis was constructed to assess factors potentially related to VF. Five hundred and eighty-eight patients were included in the analysis with a median time of viral suppression before the switch of 37 months (IQR 12-78), of whom 148 (25.2%) had at least one previous NRTIs resistance mutation. In the multivariable model no association was observed between NRTIs mutations and VF. Conversely, the duration of viral suppression before switch resulted associated with a lower risk of VF (for 1 month increase, adjusted Hazard Ratio 0.98, 95%CI 0.96-0.99; p=0.024). Previous NRTIs mutations appeared to have no impact on the risk of VF in patients switched to DTG+2NRTIs, whereas a longer interval on a controlled viremia decreased significantly the risk of VF.

Published
2019

22. Long-term maintenance of virologic suppression in native and migrant HIV-1 naïve patients: an Italian cohort study.

Author

Lagi, Filippo, Kiros, Seble Tekle, Di Giambenedetto, Simona, Lombardi, Francesca, Pecorari, Monica, Borghi, Vanni, Lepore, Luciana, Monno, Laura, Setti, Maurizio, Micheli, Valeria, Bagnarelli, Patrizia, Paolini, Elisabetta, Bai, Francesca, Bartoloni, Alessandro, and Sterrantino, Gaetana

Subjects
HIV-positive persons, NOMADS, CONFIDENCE intervals, VIRAL load, MULTIVARIATE analysis, LOG-rank test, REGRESSION analysis, ANTIRETROVIRAL agents, KAPLAN-Meier estimator, DESCRIPTIVE statistics
Abstract

Little is known about long-term maintenance of virologic suppression in HIV migrants in Italy. The study aims to compare virologic failure rates and associated factors among antiretroviral therapy (ART)-naïve migrants and natives enrolled in the ARCA database since 2007 who achieved virologic suppression within 18 months from the beginning of the ART. Kaplan-Meier method assessed the probability of virologic suppression and failure. Cox regression model was used for multivariate analysis. Of 2515 patients, 2020 (80.3%) were Italian, 286 (10.6%) migrants from low-income countries, of whom 201 (75.0%) from Africa, and 227 (9.0%) from high-income-countries. The median follow-up was 4.5 years (IQR 2.5–7). No difference was observed in the time of achievement of virological suppression in the three groups (log-rank: p = 0.5687). Higher probability of virologic failure was observed in Africans compared to Italians, to patients from high-income-countries and from low-income-countries other than Africans (Log-rank = p < 0.001). In the adjusted analysis, a higher virologic failure risk was found in Africans only compared to Italians. [HR 4.01; 95% CI 2.44–6.56, p < 0.001]. In Italy, African migrants are less likely to maintain virologic suppression compared to natives and other migrants. Targeted interventions could be needed for foreigners, especially for Africans. [ABSTRACT FROM AUTHOR]

Published
2021
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25. Down Syndrome patients with COVID-19 pneumonia: A high-risk category for unfavourable outcome

Author

Abbonizio, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Chiappini, Roberta, Ciaralli, Carmine, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, Angelis, Alessia De, Angelis, Giada De, Lorenzo, Rachele Di, Stefano, Federica Di, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Greci, Maria Cristina, Ippolito, Giuseppe, Lalle, Eleonora, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Montaldo, Francesco Messina Chiara, Murachelli, Silvia, Nicastri, Emanuele, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Vita, Serena, Di Bari, Virginia, Goletti, Delia, Espinosa, Joaquin, Petracca, Sebastiano, and Palmieri, Fabrizio

Published
2021
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26. Acute respiratory distress syndrome due to SARS-CoV-2 and Influenza A co-infection in an Italian patient: Mini-review of the literature.

Author

D'Abramo, Alessandra, Lepore, Luciana, Palazzolo, Claudia, Barreca, Filippo, Liuzzi, Giuseppina, Lalle, Eleonora, and Nicastri, Emanuele

Subjects
*ADULT respiratory distress syndrome, *SARS-CoV-2, *MIXED infections, *INFLUENZA, *COVID-19
Abstract

• Acute respiratory distress syndrome due to SARS-CoV-2 and Influenza A co-infection. • Challenging in co-infection cases identification. • Improvement of preventive measures and patients' clinical outcome. A case of acute respiratory distress syndrome due to SARS-CoV-2 and Influenza A co-infection and a mini-review of the literature is reported. Even in COVID-19 epidemics, the early identification of concurrent respiratory pathogens is important to improve etiological diagnosis, preventive measures and patients' clinical management and outcome. [ABSTRACT FROM AUTHOR]

Published
2020
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27. Coronavirus disease (COVID-19) in a paucisymptomatic patient: epidemiological and clinical challenge in settings with limited community transmission, Italy, February 2020.

Author

Nicastri, Emanuele, D'Abramo, Alessandra, Faggioni, Giovanni, De Santis, Riccardo, Mariano, Andrea, Lepore, Luciana, Molinari, Filippo, Petralito, Giancarlo, Fillo, Silvia, Munzi, Diego, Corpolongo, Angela, Bordi, Licia, Carletti, Fabrizio, Castiletti, Concetta, Colavita, Francesca, Lalle, Eleonora, Bevilacqua, Nazario, Giancola, Maria Letizia, Scorzolini, Laura, and Lanini, Simone

Published
2020
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28. Imported severe malaria and risk factors for intensive care: A single-centre retrospective analysis.

Author

D'Abramo, Alessandra, Lepore, Luciana, Iannetta, Marco, Gebremeskel Tekle, Saba, Corpolongo, Angela, Scorzolini, Laura, Bevilacqua, Nazario, Mariano, Andrea, Giancola, Maria Letizia, Vulcano, Antonella, Maritti, Micaela, Agresta, Alessandro, Antonini, Mario, D'Alessandro, Umberto, and Nicastri, Emanuele

Subjects
*CRITICAL care medicine, *MALARIA, *DISEASE risk factors, *ASPARTATE aminotransferase, *RETROSPECTIVE studies, *COMMUNICABLE diseases
Abstract

Objectives: This study aims to identify the risk factors for intensive care (IC) in severe malaria patients admitted to the "Lazzaro Spallanzani" National Institute for Infectious Diseases, Rome, Italy. Methods: All patients with confirmed severe malaria and hospitalized between 2007 and 2015 were included in the analysis and stratified into two groups: those requiring IC and those who did not. Five prognostic malaria scores were estimated; clinical severity at IC unit admission was assessed using the Sequential Organ Failure Assessment and the quick-Sequential Organ Failure Assessment scores. Univariate and multivariate analysis were performed to assess factors independently associated to IC. Results: A total of 98 severe malaria patients were included; 10 of them required IC. There were no deaths or sequelae. Patients requiring IC had higher severity scores. At the multivariate analysis, only the number of World Health Organization criteria and the aspartate aminotransferase value were independently associated with the need of IC. Conclusions: An early and accurate assessment of the severity score is essential for the management of severe malaria patients. [ABSTRACT FROM AUTHOR]

Published
2019
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30. Virological Characterization of the First 2 COVID-19 Patients Diagnosed in Italy: Phylogenetic Analysis, Virus Shedding Profile From Different Body Sites, and Antibody Response Kinetics

Author

Colavita, Francesca, Lapa, Daniele, Carletti, Fabrizio, Lalle, Eleonora, Messina, Francesco, Rueca, Martina, Matusali, Giulia, Meschi, Silvia, Bordi, Licia, Marsella, Patrizia, Nicastri, Emanuele, Marchioni, Luisa, Mariano, Andrea, Scorzolini, Laura, Ascoli Bartoli, Tommaso, Di Caro, Antonino, Ippolito, Giuseppe, Capobianchi, Maria Rosaria, Castilletti, Concetta, Abbate, Isabella, Agrati, Chiara, Aleo, Loredana, Alonzi, Tonino, Amendola, Alessandra, Apollonio, Claudia, Arduini, Nicolina, Bartolini, Barbara, Berno, Giulia, Biancone, Silvia, Biava, Mirella, Bibbò, Angela, Brega, Carla, Canali, Marco, Cannas, Angela, Carrara, Stefania, Casetti, Rita, Chiappini, Roberta, Ciafrone, Lucia, Cimini, Eleonora, Coen, Sabrina, Condello, Rossella, Coppola, Antonio, D’Arezzo, Silvia, Di Filippo, Stefania, Di Giuli, Chiara, Fabeni, Lavinia, Felici, Luisa, Ferraioli, Valeria, Forbici, Federica, Garbuglia, Anna Rosa, Giombini, Emanuela, Gori, Caterina, Graziano, Silvia, Gruber, Cesare Ernesto Maria, Khouri, Daniele, Leone, Barbara, Massimino, Chiara, Mazzarelli, Antonio, Minosse, Claudia, Montaldo, Claudia, Neri, Stefania, Nisii, Carla, Petrivelli, Elisabetta, Petroni, Fabrizio, Petruccioli, Elisa, Pisciotta, Marina, Pizzi, Daniele, Prota, Gianluca, Raparelli, Fabrizio, Rozera, Gabriella, Sabatini, Rossella, Sarti, Silvia, Sberna, Giuseppe, Sciamanna, Roberta, Selleri, Marina, Selvaggi, Carla, Sias, Catia, Stellitano, Chiara, Toffoletti, Antonietta, Truffa, Silvia, Turchi, Federica, Valli, Maria Beatrice, Venditti, Carolina, Vescovo, Tiziana, Vincenti, Donatella, Vulcano, Antonella, Zambelli, Emma, Abbonizio, Maria Alessandra, Albarello, Fabrizio, Amadei, Gioia, Antonini, Mario, Barbaro, Raffaella, Benigni, Martina, Bevilacqua, Nazario, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Caporale, Cinzia, Caravella, Ilaria, Ciaralli, Carmine, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, Di Lorenzo, Rachele, Di Stefano, Federica, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Greci, Maria Cristina, Lanini, Simone, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Marini, Maria Cristina, Maritti, Micaela, Montaldo, Chiara, Murachelli, Silvia, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Stazi, Giulia, Vaia, Francesco, and Vairo, Francesco

Subjects
0301 basic medicine, Immunoglobulin A, Immunoglobulin G, Virus, NO, Serology, 03 medical and health sciences, 0302 clinical medicine, Major Article, SARS-cov-2, Medicine, 030212 general & internal medicine, Viral shedding, Neutralizing antibody, Phylogenesis, biology, Viral culture, business.industry, Antibody response, COVID-19, Italy, Virus shedding, 3. Good health, AcademicSubjects/MED00290, 030104 developmental biology, Infectious Diseases, Oncology, Immunoglobulin M, Immunology, biology.protein, business
Abstract

Background The pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unclear. We report the detection of viral RNA from different anatomical districts and the antibody profile in the first 2 COVID-19 cases diagnosed in Italy. Methods We tested for SARS-CoV-2 RNA clinical samples, either respiratory and nonrespiratory (ie, saliva, serum, urine, vomit, rectal, ocular, cutaneous, and cervico-vaginal swabs), longitudinally collected from both patients throughout the hospitalization. Serological analysis was carried out on serial serum samples to evaluate IgM, IgA, IgG, and neutralizing antibody levels. Results SARS-CoV-2 RNA was detected since the early phase of illness, lasting over 2 weeks in both upper and lower respiratory tract samples. Virus isolate was obtained from acute respiratory samples, while no infectious virus was rescued from late respiratory samples with low viral RNA load, collected when serum antibodies had been developed. Several other specimens came back positive, including saliva, vomit, rectal, cutaneous, cervico-vaginal, and ocular swabs. IgM, IgA, and IgG were detected within the first week of diagnosis, with IgG appearing earlier and at higher titers. Neutralizing antibodies developed during the second week, reaching high titers 32 days after diagnosis. Conclusions Our longitudinal analysis showed that SARS-CoV-2 RNA can be detected in different body samples, which may be associated with broad tropism and different spectra of clinical manifestations and modes of transmission. Profiling antibody response and neutralizing activity can assist in laboratory diagnosis and surveillance actions.

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31. Coronavirus disease (COVID-19) in a paucisymptomatic patient: epidemiological and clinical challenge in settings with limited community transmission, Italy, February 2020.

Author

Nicastri E, D'Abramo A, Faggioni G, De Santis R, Mariano A, Lepore L, Molinari F, Petralito G, Fillo S, Munzi D, Corpolongo A, Bordi L, Carletti F, Castiletti C, Colavita F, Lalle E, Bevilacqua N, Giancola ML, Scorzolini L, Lanini S, Palazzolo C, De Domenico A, Spinelli MA, Scognamiglio P, Piredda P, Iacomino R, Mone A, Puro V, Petrosillo N, Battistini A, Vairo F, Lista F, and Ippolito G

Subjects
Antibodies, Viral immunology, Betacoronavirus, COVID-19, COVID-19 Testing, China, Clinical Laboratory Techniques, Contact Tracing, Coronavirus genetics, Coronavirus Infections transmission, Coronavirus Infections virology, Humans, Italy, Lung pathology, Male, Pandemics, Pneumonia, Viral therapy, Pneumonia, Viral transmission, Pneumonia, Viral virology, Quarantine, Radiography, Thoracic, Real-Time Polymerase Chain Reaction, SARS-CoV-2, Tomography, X-Ray Computed, World Health Organization, Young Adult, Asymptomatic Infections, Coronavirus isolation & purification, Coronavirus Infections diagnosis, Feces virology, Lung diagnostic imaging, Nasopharynx virology, Pneumonia, Viral diagnosis, Travel, Virus Shedding
Abstract

Data concerning the transmission of the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) in paucisymptomatic patients are lacking. We report an Italian paucisymptomatic case of coronavirus disease 2019 with multiple biological samples positive for SARS-CoV-2. This case was detected using the World Health Organization protocol on cases and contact investigation. Current discharge criteria and the impact of extra-pulmonary SARS-CoV-2 samples are discussed.

Published
2020
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32. Clinical management of imported malaria in Italy: results from a national cross-sectional survey in 2015.

Author

Lepore L, Vairo F, D'Abramo A, Grilli E, Corpolongo A, Scorzolini L, Nisii C, Calleri G, Castelli F, Chirianni A, Ippolito G, and Nicastri E

Subjects
Cross-Sectional Studies, Humans, Italy, Plasmodium, Retrospective Studies, Surveys and Questionnaires, Antimalarials therapeutic use, Malaria drug therapy, Malaria prevention & control, Travel
Abstract

In Italy, malaria continues to be one of the most common imported parasitoses; therefore, continuous surveillance of epidemiological data and clinical management is needed. In 2016, the National Institute for Infectious Diseases 'Lazzaro Spallanzani' in Rome promoted a retrospective questionnaire-based survey to assess the clinical management of imported malaria cases in Italy in 2015. The questionnaire was sent to 104 Tropical and/or Infectious Diseases Units in the country, and 37 of them filled out and returned the questionnaires. A total of 399 malaria cases were reported in 2015, mostly caused by Plasmodium falciparum and imported from Africa. Malaria chemoprophylaxis was correctly used by a minority of patients. Most patients presented with uncomplicated malaria and were treated orally. In severe cases, intravenous artesunate or quinine alone or in combination were administered, although one third of these severe cases received oral treatment. This retrospective survey reveals a lack of homogeneity in management of malaria-imported cases in Italy. Improvement of malaria chemoprophylaxis, standardization of clinical management of malaria cases and harmonization of oral and intravenous drug availability are needed throughout the country.

Published
2020

33. Dengue fever in travellers and risk of local spreading: case reports from Southern Italy and literature update.

Author

Fabrizio C, Lepore L, Chironna M, Angarano G, and Saracino A

Subjects
Adult, Disease Notification, Dominican Republic epidemiology, Female, Humans, Italy epidemiology, Male, Polynesia epidemiology, Travel, Young Adult, Dengue epidemiology
Abstract

Dengue fever (DF), an arbovirosis caused by Dengue viruses (DV, serotypes 1-4), is responsible for an increasing number of travel-related acute febrile illnesses due to population growth, climate changes, spreading by viremic travellers, and improved laboratory diagnosis. The presence of efficient vectors (mosquito Aedes albopictus) has also been described in temperate regions including Italy which is considered the most heavily infected European country. Normally characterized by non-specific signs and symptoms, DF incidence is probably underestimated, especially in non-endemic countries, but the risk of severe forms is substantial. Between August and November 2013, five DF patients (4 males, age 23-38) were observed in the Infectious Disease Clinic (University of Bari, Southern Italy). All had just returned from DF endemic areas (2 French Polynesia, 3 Dominican Republic); 4/5 were hospitalized. Common clinical features included acute febrile syndrome, headache (2 with retro-orbital pain), rash (all patients), two with bleeding manifestations and one with gum bleeding. Laboratory tests demonstrated leukopenia (4 patients), elevated liver enzymes (3 patients), and thrombocytopenia (1 patient). Serum samples for DV antibodies and RNA detection were analyzed by the Regional Arbovirosis Reference Laboratory. Viral RNA was identified in 2/5 patients (DV-4) and seroconversion in the remaining cases. All patients made a complete recovery. Recent literature was reviewed, focusing on epidemiology and vector distribution (especially European and Italian territories), pathogenesis, clinical features, diagnosis, and treatment including vaccine strategies. The occurrence of 5 DF cases during the period of highest vector activity (June-November) in Italy emphasizes the risk of local outbreaks in temperate regions. This paper highlights the importance of clinical alert for dengue also in non-endemic countries.

Published
2017

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