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2. Time to Adjuvant Chemotherapy for Breast Cancer in National Comprehensive Cancer Network Institutions

Author

Vandergrift, Jonathan L, Niland, Joyce C, Theriault, Richard L, Edge, Stephen B, Wong, Yu-Ning, Loftus, Loretta S, Breslin, Tara M, Hudis, Clifford A, Javid, Sara H, Rugo, Hope S, Silver, Samuel M, Lepisto, Eva M, and Weeks, Jane C

Subjects
Cancer, Breast Cancer, Clinical Research, Adult, African Americans, Aged, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Cancer Care Facilities, Chemotherapy, Adjuvant, Confounding Factors, Epidemiologic, Drug Administration Schedule, Female, Healthcare Disparities, Humans, Insurance, Health, Lymph Node Excision, Magnetic Resonance Imaging, Mammaplasty, Mastectomy, Medicaid, Medicare, Middle Aged, Neoplasm Staging, Referral and Consultation, Time Factors, United States, Whites, White People, Black or African American, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundHigh-quality care must be not only appropriate but also timely. We assessed time to initiation of adjuvant chemotherapy for breast cancer as well as factors associated with delay to help identify targets for future efforts to reduce unnecessary delays.MethodsUsing data from the National Comprehensive Cancer Network (NCCN) Outcomes Database, we assessed the time from pathological diagnosis to initiation of chemotherapy (TTC) among 6622 women with stage I to stage III breast cancer diagnosed from 2003 through 2009 and treated with adjuvant chemotherapy in nine NCCN centers. Multivariable models were constructed to examine factors associated with TTC. All statistical tests were two-sided.ResultsMean TTC was 12.0 weeks overall and increased over the study period. A number of factors were associated with a longer TTC. The largest effects were associated with therapeutic factors, including immediate postmastectomy reconstruction (2.7 weeks; P < .001), re-excision (2.1 weeks; P < .001), and use of the 21-gene reverse-transcription polymerase chain reaction assay (2.2 weeks; P < .001). In comparison with white women, a longer TTC was observed among black (1.5 weeks; P < .001) and Hispanic (0.8 weeks; P < .001) women. For black women, the observed disparity was greater among women who transferred their care to the NCCN center after diagnosis (P (interaction) = .008) and among women with Medicare vs commercial insurance (P (interaction) < .001).ConclusionsMost observed variation in TTC was related to use of appropriate therapeutic interventions. This suggests the importance of targeted efforts to minimize potentially preventable causes of delay, including inefficient transfers in care or prolonged appointment wait times.

Published
2013

4. Data from Characteristics and Outcome of AKT1E17K-Mutant Breast Cancer Defined through AACR Project GENIE, a Clinicogenomic Registry

Author

Smyth, Lillian M., primary, Zhou, Qin, primary, Nguyen, Bastien, primary, Yu, Celeste, primary, Lepisto, Eva M., primary, Arnedos, Monica, primary, Hasset, Michael J., primary, Lenoue-Newton, Michele L., primary, Blauvelt, Natalie, primary, Dogan, Semih, primary, Micheel, Christine M., primary, Wathoo, Chetna, primary, Horlings, Hugo, primary, Hudecek, Jan, primary, Gross, Benjamin E., primary, Kundra, Ritika, primary, Sweeney, Shawn M., primary, Gao, JianJiong, primary, Schultz, Nikolaus, primary, Zarski, Andrew, primary, Gardos, Stuart M., primary, Lee, Jocelyn, primary, Sheffler-Collins, Seth, primary, Park, Ben H., primary, Sawyers, Charles L., primary, André, Fabrice, primary, Levy, Mia, primary, Meric-Bernstam, Funda, primary, Bedard, Philippe L., primary, Iasonos, Alexia, primary, Schrag, Deborah, primary, and Hyman, David M., primary

Published
2023
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5. Data from AACR Project GENIE: Powering Precision Medicine through an International Consortium

Author

André, Fabrice, primary, Arnedos, Monica, primary, Baras, Alexander S., primary, Baselga, José, primary, Bedard, Philippe L., primary, Berger, Michael F., primary, Bierkens, Mariska, primary, Calvo, Fabien, primary, Cerami, Ethan, primary, Chakravarty, Debyani, primary, Dang, Kristen K., primary, Davidson, Nancy E., primary, Del Vecchio Fitz, Catherine, primary, Dogan, Semih, primary, DuBois, Raymond N., primary, Ducar, Matthew D., primary, Futreal, P. Andrew, primary, Gao, Jianjiong, primary, Garcia, Francisco, primary, Gardos, Stu, primary, Gocke, Christopher D., primary, Gross, Benjamin E., primary, Guinney, Justin, primary, Heins, Zachary J., primary, Hintzen, Stephanie, primary, Horlings, Hugo, primary, Hudeček, Jan, primary, Hyman, David M., primary, Kamel-Reid, Suzanne, primary, Kandoth, Cyriac, primary, Kinyua, Walter, primary, Kumari, Priti, primary, Kundra, Ritika, primary, Ladanyi, Marc, primary, Lefebvre, Céline, primary, LeNoue-Newton, Michele L., primary, Lepisto, Eva M., primary, Levy, Mia A., primary, Lindeman, Neal I., primary, Lindsay, James, primary, Liu, David, primary, Lu, Zhibin, primary, MacConaill, Laura E., primary, Maurer, Ian, primary, Maxwell, David S., primary, Meijer, Gerrit A., primary, Meric-Bernstam, Funda, primary, Micheel, Christine M., primary, Miller, Clinton, primary, Mills, Gordon, primary, Moore, Nathanael D., primary, Nederlof, Petra M., primary, Omberg, Larsson, primary, Orechia, John A., primary, Park, Ben Ho, primary, Pugh, Trevor J., primary, Reardon, Brendan, primary, Rollins, Barrett J., primary, Routbort, Mark J., primary, Sawyers, Charles L., primary, Schrag, Deborah, primary, Schultz, Nikolaus, primary, Shaw, Kenna R Mills, primary, Shivdasani, Priyanka, primary, Siu, Lillian L., primary, Solit, David B., primary, Sonke, Gabe S., primary, Soria, Jean Charles, primary, Sripakdeevong, Parin, primary, Stickle, Natalie H., primary, Stricker, Thomas P., primary, Sweeney, Shawn M., primary, Taylor, Barry S., primary, ten Hoeve, Jelle J., primary, Thomas, Stacy B., primary, Van Allen, Eliezer M., primary, Van 'T Veer, Laura J., primary, van de Velde, Tony, primary, van Tinteren, Harm, primary, Velculescu, Victor E., primary, Virtanen, Carl, primary, Voest, Emile E., primary, Wang, Lucy L., primary, Wathoo, Chetna, primary, Watt, Stuart, primary, Yu, Celeste, primary, Yu, Thomas V., primary, Yu, Emily, primary, Zehir, Ahmet, primary, and Zhang, Hongxin, primary

Published
2023
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6. Table S3 from AACR Project GENIE: Powering Precision Medicine through an International Consortium

Author

André, Fabrice, primary, Arnedos, Monica, primary, Baras, Alexander S., primary, Baselga, José, primary, Bedard, Philippe L., primary, Berger, Michael F., primary, Bierkens, Mariska, primary, Calvo, Fabien, primary, Cerami, Ethan, primary, Chakravarty, Debyani, primary, Dang, Kristen K., primary, Davidson, Nancy E., primary, Del Vecchio Fitz, Catherine, primary, Dogan, Semih, primary, DuBois, Raymond N., primary, Ducar, Matthew D., primary, Futreal, P. Andrew, primary, Gao, Jianjiong, primary, Garcia, Francisco, primary, Gardos, Stu, primary, Gocke, Christopher D., primary, Gross, Benjamin E., primary, Guinney, Justin, primary, Heins, Zachary J., primary, Hintzen, Stephanie, primary, Horlings, Hugo, primary, Hudeček, Jan, primary, Hyman, David M., primary, Kamel-Reid, Suzanne, primary, Kandoth, Cyriac, primary, Kinyua, Walter, primary, Kumari, Priti, primary, Kundra, Ritika, primary, Ladanyi, Marc, primary, Lefebvre, Céline, primary, LeNoue-Newton, Michele L., primary, Lepisto, Eva M., primary, Levy, Mia A., primary, Lindeman, Neal I., primary, Lindsay, James, primary, Liu, David, primary, Lu, Zhibin, primary, MacConaill, Laura E., primary, Maurer, Ian, primary, Maxwell, David S., primary, Meijer, Gerrit A., primary, Meric-Bernstam, Funda, primary, Micheel, Christine M., primary, Miller, Clinton, primary, Mills, Gordon, primary, Moore, Nathanael D., primary, Nederlof, Petra M., primary, Omberg, Larsson, primary, Orechia, John A., primary, Park, Ben Ho, primary, Pugh, Trevor J., primary, Reardon, Brendan, primary, Rollins, Barrett J., primary, Routbort, Mark J., primary, Sawyers, Charles L., primary, Schrag, Deborah, primary, Schultz, Nikolaus, primary, Shaw, Kenna R Mills, primary, Shivdasani, Priyanka, primary, Siu, Lillian L., primary, Solit, David B., primary, Sonke, Gabe S., primary, Soria, Jean Charles, primary, Sripakdeevong, Parin, primary, Stickle, Natalie H., primary, Stricker, Thomas P., primary, Sweeney, Shawn M., primary, Taylor, Barry S., primary, ten Hoeve, Jelle J., primary, Thomas, Stacy B., primary, Van Allen, Eliezer M., primary, Van 'T Veer, Laura J., primary, van de Velde, Tony, primary, van Tinteren, Harm, primary, Velculescu, Victor E., primary, Virtanen, Carl, primary, Voest, Emile E., primary, Wang, Lucy L., primary, Wathoo, Chetna, primary, Watt, Stuart, primary, Yu, Celeste, primary, Yu, Thomas V., primary, Yu, Emily, primary, Zehir, Ahmet, primary, and Zhang, Hongxin, primary

Published
2023
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7. Supplementary Data from Characteristics and Outcome of AKT1E17K-Mutant Breast Cancer Defined through AACR Project GENIE, a Clinicogenomic Registry

Author

Smyth, Lillian M., primary, Zhou, Qin, primary, Nguyen, Bastien, primary, Yu, Celeste, primary, Lepisto, Eva M., primary, Arnedos, Monica, primary, Hasset, Michael J., primary, Lenoue-Newton, Michele L., primary, Blauvelt, Natalie, primary, Dogan, Semih, primary, Micheel, Christine M., primary, Wathoo, Chetna, primary, Horlings, Hugo, primary, Hudecek, Jan, primary, Gross, Benjamin E., primary, Kundra, Ritika, primary, Sweeney, Shawn M., primary, Gao, JianJiong, primary, Schultz, Nikolaus, primary, Zarski, Andrew, primary, Gardos, Stuart M., primary, Lee, Jocelyn, primary, Sheffler-Collins, Seth, primary, Park, Ben H., primary, Sawyers, Charles L., primary, André, Fabrice, primary, Levy, Mia, primary, Meric-Bernstam, Funda, primary, Bedard, Philippe L., primary, Iasonos, Alexia, primary, Schrag, Deborah, primary, and Hyman, David M., primary

Published
2023
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8. Supplemental Methods, Supplemental Tables 1-2, Supplemental Figures 1-4 from AACR Project GENIE: Powering Precision Medicine through an International Consortium

Author

André, Fabrice, primary, Arnedos, Monica, primary, Baras, Alexander S., primary, Baselga, José, primary, Bedard, Philippe L., primary, Berger, Michael F., primary, Bierkens, Mariska, primary, Calvo, Fabien, primary, Cerami, Ethan, primary, Chakravarty, Debyani, primary, Dang, Kristen K., primary, Davidson, Nancy E., primary, Del Vecchio Fitz, Catherine, primary, Dogan, Semih, primary, DuBois, Raymond N., primary, Ducar, Matthew D., primary, Futreal, P. Andrew, primary, Gao, Jianjiong, primary, Garcia, Francisco, primary, Gardos, Stu, primary, Gocke, Christopher D., primary, Gross, Benjamin E., primary, Guinney, Justin, primary, Heins, Zachary J., primary, Hintzen, Stephanie, primary, Horlings, Hugo, primary, Hudeček, Jan, primary, Hyman, David M., primary, Kamel-Reid, Suzanne, primary, Kandoth, Cyriac, primary, Kinyua, Walter, primary, Kumari, Priti, primary, Kundra, Ritika, primary, Ladanyi, Marc, primary, Lefebvre, Céline, primary, LeNoue-Newton, Michele L., primary, Lepisto, Eva M., primary, Levy, Mia A., primary, Lindeman, Neal I., primary, Lindsay, James, primary, Liu, David, primary, Lu, Zhibin, primary, MacConaill, Laura E., primary, Maurer, Ian, primary, Maxwell, David S., primary, Meijer, Gerrit A., primary, Meric-Bernstam, Funda, primary, Micheel, Christine M., primary, Miller, Clinton, primary, Mills, Gordon, primary, Moore, Nathanael D., primary, Nederlof, Petra M., primary, Omberg, Larsson, primary, Orechia, John A., primary, Park, Ben Ho, primary, Pugh, Trevor J., primary, Reardon, Brendan, primary, Rollins, Barrett J., primary, Routbort, Mark J., primary, Sawyers, Charles L., primary, Schrag, Deborah, primary, Schultz, Nikolaus, primary, Shaw, Kenna R Mills, primary, Shivdasani, Priyanka, primary, Siu, Lillian L., primary, Solit, David B., primary, Sonke, Gabe S., primary, Soria, Jean Charles, primary, Sripakdeevong, Parin, primary, Stickle, Natalie H., primary, Stricker, Thomas P., primary, Sweeney, Shawn M., primary, Taylor, Barry S., primary, ten Hoeve, Jelle J., primary, Thomas, Stacy B., primary, Van Allen, Eliezer M., primary, Van 'T Veer, Laura J., primary, van de Velde, Tony, primary, van Tinteren, Harm, primary, Velculescu, Victor E., primary, Virtanen, Carl, primary, Voest, Emile E., primary, Wang, Lucy L., primary, Wathoo, Chetna, primary, Watt, Stuart, primary, Yu, Celeste, primary, Yu, Thomas V., primary, Yu, Emily, primary, Zehir, Ahmet, primary, and Zhang, Hongxin, primary

Published
2023
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9. Supplemental File 1 from AACR Project GENIE: Powering Precision Medicine through an International Consortium

Author

André, Fabrice, primary, Arnedos, Monica, primary, Baras, Alexander S., primary, Baselga, José, primary, Bedard, Philippe L., primary, Berger, Michael F., primary, Bierkens, Mariska, primary, Calvo, Fabien, primary, Cerami, Ethan, primary, Chakravarty, Debyani, primary, Dang, Kristen K., primary, Davidson, Nancy E., primary, Del Vecchio Fitz, Catherine, primary, Dogan, Semih, primary, DuBois, Raymond N., primary, Ducar, Matthew D., primary, Futreal, P. Andrew, primary, Gao, Jianjiong, primary, Garcia, Francisco, primary, Gardos, Stu, primary, Gocke, Christopher D., primary, Gross, Benjamin E., primary, Guinney, Justin, primary, Heins, Zachary J., primary, Hintzen, Stephanie, primary, Horlings, Hugo, primary, Hudeček, Jan, primary, Hyman, David M., primary, Kamel-Reid, Suzanne, primary, Kandoth, Cyriac, primary, Kinyua, Walter, primary, Kumari, Priti, primary, Kundra, Ritika, primary, Ladanyi, Marc, primary, Lefebvre, Céline, primary, LeNoue-Newton, Michele L., primary, Lepisto, Eva M., primary, Levy, Mia A., primary, Lindeman, Neal I., primary, Lindsay, James, primary, Liu, David, primary, Lu, Zhibin, primary, MacConaill, Laura E., primary, Maurer, Ian, primary, Maxwell, David S., primary, Meijer, Gerrit A., primary, Meric-Bernstam, Funda, primary, Micheel, Christine M., primary, Miller, Clinton, primary, Mills, Gordon, primary, Moore, Nathanael D., primary, Nederlof, Petra M., primary, Omberg, Larsson, primary, Orechia, John A., primary, Park, Ben Ho, primary, Pugh, Trevor J., primary, Reardon, Brendan, primary, Rollins, Barrett J., primary, Routbort, Mark J., primary, Sawyers, Charles L., primary, Schrag, Deborah, primary, Schultz, Nikolaus, primary, Shaw, Kenna R Mills, primary, Shivdasani, Priyanka, primary, Siu, Lillian L., primary, Solit, David B., primary, Sonke, Gabe S., primary, Soria, Jean Charles, primary, Sripakdeevong, Parin, primary, Stickle, Natalie H., primary, Stricker, Thomas P., primary, Sweeney, Shawn M., primary, Taylor, Barry S., primary, ten Hoeve, Jelle J., primary, Thomas, Stacy B., primary, Van Allen, Eliezer M., primary, Van 'T Veer, Laura J., primary, van de Velde, Tony, primary, van Tinteren, Harm, primary, Velculescu, Victor E., primary, Virtanen, Carl, primary, Voest, Emile E., primary, Wang, Lucy L., primary, Wathoo, Chetna, primary, Watt, Stuart, primary, Yu, Celeste, primary, Yu, Thomas V., primary, Yu, Emily, primary, Zehir, Ahmet, primary, and Zhang, Hongxin, primary

Published
2023
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10. Supplementary Figure from Natural History and Characteristics of ERBB2-mutated Hormone Receptor–positive Metastatic Breast Cancer: A Multi-institutional Retrospective Case–control Study from AACR Project GENIE

Author

LeNoue-Newton, Michele L., primary, Chen, Sheau-Chiann, primary, Stricker, Thomas, primary, Hyman, David M., primary, Blauvelt, Natalie, primary, Bedard, Philippe L., primary, Meric-Bernstam, Funda, primary, Punglia, Rinaa S., primary, Schrag, Deborah, primary, Lepisto, Eva M., primary, Andre, Fabrice, primary, Smyth, Lillian, primary, Dogan, Semih, primary, Yu, Celeste, primary, Wathoo, Chetna, primary, Levy, Mia, primary, Eli, Lisa D., primary, Xu, Feng, primary, Mann, Grace, primary, Lalani, Alshad S., primary, Ye, Fei, primary, Micheel, Christine M., primary, and Arnedos, Monica, primary

Published
2023
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11. Supplementary Table from Natural History and Characteristics of ERBB2-mutated Hormone Receptor–positive Metastatic Breast Cancer: A Multi-institutional Retrospective Case–control Study from AACR Project GENIE

Author

LeNoue-Newton, Michele L., primary, Chen, Sheau-Chiann, primary, Stricker, Thomas, primary, Hyman, David M., primary, Blauvelt, Natalie, primary, Bedard, Philippe L., primary, Meric-Bernstam, Funda, primary, Punglia, Rinaa S., primary, Schrag, Deborah, primary, Lepisto, Eva M., primary, Andre, Fabrice, primary, Smyth, Lillian, primary, Dogan, Semih, primary, Yu, Celeste, primary, Wathoo, Chetna, primary, Levy, Mia, primary, Eli, Lisa D., primary, Xu, Feng, primary, Mann, Grace, primary, Lalani, Alshad S., primary, Ye, Fei, primary, Micheel, Christine M., primary, and Arnedos, Monica, primary

Published
2023
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12. Data from Natural History and Characteristics of ERBB2-mutated Hormone Receptor–positive Metastatic Breast Cancer: A Multi-institutional Retrospective Case–control Study from AACR Project GENIE

Author

LeNoue-Newton, Michele L., primary, Chen, Sheau-Chiann, primary, Stricker, Thomas, primary, Hyman, David M., primary, Blauvelt, Natalie, primary, Bedard, Philippe L., primary, Meric-Bernstam, Funda, primary, Punglia, Rinaa S., primary, Schrag, Deborah, primary, Lepisto, Eva M., primary, Andre, Fabrice, primary, Smyth, Lillian, primary, Dogan, Semih, primary, Yu, Celeste, primary, Wathoo, Chetna, primary, Levy, Mia, primary, Eli, Lisa D., primary, Xu, Feng, primary, Mann, Grace, primary, Lalani, Alshad S., primary, Ye, Fei, primary, Micheel, Christine M., primary, and Arnedos, Monica, primary

Published
2023
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14. Natural History and Characteristics of ERBB2-mutated Hormone Receptor–positive Metastatic Breast Cancer: A Multi-institutional Retrospective Case–control Study from AACR Project GENIE

Author

LeNoue-Newton, Michele L., primary, Chen, Sheau-Chiann, additional, Stricker, Thomas, additional, Hyman, David M., additional, Blauvelt, Natalie, additional, Bedard, Philippe L., additional, Meric-Bernstam, Funda, additional, Punglia, Rinaa S., additional, Schrag, Deborah, additional, Lepisto, Eva M., additional, Andre, Fabrice, additional, Smyth, Lillian, additional, Dogan, Semih, additional, Yu, Celeste, additional, Wathoo, Chetna, additional, Levy, Mia, additional, Eli, Lisa D., additional, Xu, Feng, additional, Mann, Grace, additional, Lalani, Alshad S., additional, Ye, Fei, additional, Micheel, Christine M., additional, and Arnedos, Monica, additional

Published
2022
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15. Clinical and genomic predictors of brain metastases (BM) in non-small cell lung cancer (NSCLC): An AACR Project GENIE analysis.

Author

Rahman, Protiva, primary, LeNoue-Newton, Michele, additional, Chaugai, Sandip, additional, Holt, Marilyn, additional, Jain, Neha M, additional, Maxwell, Christina, additional, Micheel, Christine, additional, Yang, Yuanchu J, additional, Ye, Cheng, additional, Schultz, Nikolaus, additional, Riely, Gregory J., additional, McCarthy, Caroline G., additional, Rizvi, Hira, additional, Schrag, Deborah, additional, Kehl, Kenneth L., additional, Lepisto, Eva M, additional, Yu, Celeste, additional, Bedard, Philippe L., additional, Fabbri, Daniel, additional, and Warner, Jeremy Lyle, additional

Published
2021
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19. Progression-free survival estimates in non-small cell lung cancer when RECIST is unavailable: Project GENIE’s integration of genomic, therapeutic and phenomic data.

Author

Lavery, Jessica A., primary, Panageas, Katherine, additional, LeNoue-Newton, Michele, additional, Sweeney, Shawn, additional, Sheffler-Collins, Seth, additional, Rudolph, Julia E, additional, Rizvi, Hira, additional, Schultz, Nikolaus, additional, Lepisto, Eva M., additional, Kehl, Kenneth L., additional, Warner, Jeremy Lyle, additional, Dang, Kristen, additional, Phillip, John, additional, Park, Ben Ho, additional, Riely, Gregory J., additional, and Schrag, Deborah, additional

Published
2020
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20. Characteristics and Outcome of AKT1E17K-Mutant Breast Cancer Defined through AACR Project GENIE, a Clinicogenomic Registry

Author

Smyth, Lillian M., primary, Zhou, Qin, additional, Nguyen, Bastien, additional, Yu, Celeste, additional, Lepisto, Eva M., additional, Arnedos, Monica, additional, Hasset, Michael J., additional, Lenoue-Newton, Michele L., additional, Blauvelt, Natalie, additional, Dogan, Semih, additional, Micheel, Christine M., additional, Wathoo, Chetna, additional, Horlings, Hugo, additional, Hudecek, Jan, additional, Gross, Benjamin E., additional, Kundra, Ritika, additional, Sweeney, Shawn M., additional, Gao, JianJiong, additional, Schultz, Nikolaus, additional, Zarski, Andrew, additional, Gardos, Stuart M., additional, Lee, Jocelyn, additional, Sheffler-Collins, Seth, additional, Park, Ben H., additional, Sawyers, Charles L., additional, André, Fabrice, additional, Levy, Mia, additional, Meric-Bernstam, Funda, additional, Bedard, Philippe L., additional, Iasonos, Alexia, additional, Schrag, Deborah, additional, and Hyman, David M., additional

Published
2020
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23. Time to Adjuvant Chemotherapy for Breast Cancer in National Comprehensive Cancer Network Institutions

Author

Vandergrift, Jonathan L., primary, Niland, Joyce C., additional, Theriault, Richard L., additional, Edge, Stephen B., additional, Wong, Yu-Ning, additional, Loftus, Loretta S., additional, Breslin, Tara M., additional, Hudis, Clifford A., additional, Javid, Sara H., additional, Rugo, Hope S., additional, Silver, Samuel M., additional, Lepisto, Eva M., additional, and Weeks, Jane C., additional

Published
2013
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25. R-CHOP, Followed by High Dose Therapy and Autologous Stem Cell Rescue (HDT/ASCR), and R-Hypercvad Have Equivalent Progression-Free Survival and Are Superior to R-CHOP Alone in Younger Patients with Mantle Cell Lymphoma: a Comparative Effectiveness Analysis From the National Comprehensive Cancer Network (NCCN) Non-Hodgkin's Lymphoma Outcomes Database Project.

Author

LaCasce, Ann, primary, Vandergrift, Jonathan L., additional, Rodriguez, Maria A., additional, Crosby, Allison L., additional, Lepisto, Eva M., additional, Czuczman, Myron S., additional, Nademanee, Auayporn P., additional, Blayney, Douglas W., additional, Gordon, Leo I., additional, Millenson, Michael, additional, Vanderplas, Ann, additional, Abel, Gregory A., additional, Zelenetz, Andrew D., additional, and Friedberg, Jonathan W., additional

Published
2009
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26. Evolution of Rituximab as “Standard” Therapy in Patients (pts) with Newly Diagnosed Follicular (FL), Mantle Cell (MCL), and Diffuse Large B Cell (DLCL) Non-Hodgkin’s Lymphoma (NHL) in 5 United States Comprehensive Cancer Centers: An Analysis from the National Comprehensive Cancer Network (NCCN) NHL Outcomes Project.

Author

Friedberg, Jonathan W., primary, Kho, Michelle E., primary, Lepisto, Eva M., primary, Rodriguez, M. Alma, primary, TerVeer, Anna, primary, LaCasce, Ann S., primary, Nademanee, Auyporn P., primary, Millenson, Michael, primary, Czuczman, Myron, primary, Niland, Joyce, primary, Zelenetz, Andrew D., primary, and Weeks, Jane C., primary

Published
2004
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28. Perceived Racism Scale

Author

McNeilly, Maya Dominguez, primary, Anderson, Norman B., additional, Armstead, Cheryl A., additional, Clark, Rodney, additional, Corbett, Marcella, additional, Robinson, Elwood L., additional, Pieper, Carl F., additional, and Lepisto, Eva M., additional

Published
1996
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33. Characteristics and Outcome of AKT1 E17K -Mutant Breast Cancer Defined through AACR Project GENIE, a Clinicogenomic Registry.

Author

Smyth LM, Zhou Q, Nguyen B, Yu C, Lepisto EM, Arnedos M, Hasset MJ, Lenoue-Newton ML, Blauvelt N, Dogan S, Micheel CM, Wathoo C, Horlings H, Hudecek J, Gross BE, Kundra R, Sweeney SM, Gao J, Schultz N, Zarski A, Gardos SM, Lee J, Sheffler-Collins S, Park BH, Sawyers CL, André F, Levy M, Meric-Bernstam F, Bedard PL, Iasonos A, Schrag D, and Hyman DM

Subjects
Adult, Aged, Aged, 80 and over, Breast Neoplasms pathology, Female, Humans, Middle Aged, Mutation, Registries, Treatment Outcome, Breast Neoplasms genetics, Proto-Oncogene Proteins c-akt metabolism
Abstract

AKT inhibitors have promising activity in AKT1 E17K -mutant estrogen receptor (ER)-positive metastatic breast cancer, but the natural history of this rare genomic subtype remains unknown. Utilizing AACR Project GENIE, an international clinicogenomic data-sharing consortium, we conducted a comparative analysis of clinical outcomes of patients with matched AKT1 E17K -mutant ( n = 153) and AKT1 -wild-type ( n = 302) metastatic breast cancer. AKT1 -mutant cases had similar adjusted overall survival (OS) compared with AKT1 -wild-type controls (median OS, 24.1 vs. 29.9, respectively; P = 0.98). AKT1 -mutant cases enjoyed longer durations on mTOR inhibitor therapy, an observation previously unrecognized in pivotal clinical trials due to the rarity of this alteration. Other baseline clinicopathologic features, as well as durations on other classes of therapy, were broadly similar. In summary, we demonstrate the feasibility of using a novel and publicly accessible clincogenomic registry to define outcomes in a rare genomically defined cancer subtype, an approach with broad applicability to precision oncology. SIGNIFICANCE: We delineate the natural history of a rare genomically distinct cancer, AKT1 E17K -mutant ER-positive breast cancer, using a publicly accessible registry of real-world patient data, thereby illustrating the potential to inform drug registration through synthetic control data. See related commentary by Castellanos and Baxi, p. 490 ., (©2020 American Association for Cancer Research.)

Published
2020
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