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14 results on '"Leotta, Valerio"'

1. Low content of clonogenic progenitors on day+18 is associated with acute graft-versus-host disease and predicts transplant-related mortality

Author

Milone, Giuseppe, Scirè, Paola, Camuglia, Maria Grazia, Triolo, Anna, Moschetti, Gaetano, Scuderi, Maria Grazia, Cupri, Alessandra, Milone, Giulio Antonio, Bulla, Anna, Giorgio, Mary Ann Di, Leotta, Valerio, Curtopelle, Angelo, Sciortino, Roberta, Parrinello, Laura, Crocchiolo, Roberto, and Leotta, Salvatore

Published
2021
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2. The role of ponatinib in adult BCR-ABL1 positive acute lymphoblastic leukemia after allogeneic transplantation: a real-life retrospective multicenter study

Author

Leotta, Salvatore, Markovic, Uros, Pirosa, Maria Cristina, Stella, Stefania, Tringali, Stefania, Martino, Massimo, Specchia, Giorgina, Carluccio, Paola, Risitano, Antonio M., Grimaldi, Francesco, Vigna, Ernesto, Palmieri, Fausto, Palmieri, Raffaele, Annunziata, Mario, Pisapia, Giovanni, Palazzo, Giulia, Milone, Giulio Antonio, Pelle, Angelo Curto, Scalise, Luca, Di Giorgio, Mary Ann, Bulla, Anna, Leotta, Valerio, Di Raimondo, Francesco, and Milone, Giuseppe

Published
2021
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3. Effectiveness, safety, and tolerability of delayed dexamethasone, rituximab, and cyclophosphamide as first-line treatment in patients with Waldenström macroglobulinemia: data from the Sicilian Myeloma Network.

Author

Del Fabro, Vittorio, Markovic, Uros, Frazzetto, Sara, Sciortino, Roberta, Bellofiore, Claudia, Di Giorgio, Mary Ann, Leotta, Valerio, Bulla, Anna, Curto Pelle, Angelo, Elia, Federica, Mannina, Donato, Consoli, Ugo, Mineo, Giuseppe, Giallongo, Cesarina, Romano, Alessandra, Di Raimondo, Francesco, and Conticello, Concetta

Published
2024
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4. Lenalidomide plus Dexamethasone Combination as First-Line Oral Therapy of Multiple Myeloma Patients: A Unicentric Real-Life Study

Author

Del Fabro, Vittorio, primary, Di Giorgio, Mary Ann, additional, Leotta, Valerio, additional, Duminuco, Andrea, additional, Bellofiore, Claudia, additional, Markovic, Uros, additional, Romano, Alessandra, additional, Bulla, Anna, additional, Curto Pelle, Angelo, additional, Elia, Federica, additional, Di Raimondo, Francesco, additional, and Conticello, Concetta, additional

Published
2023
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6. Early Salvage Treatment with Second-Generation Novel Agents at Biochemical Relapse Prolongs Overall Survival: A Real-World Single Center Experience

Author

Markovic, Uros, primary, Leotta, Valerio, additional, Romano, Alessandra, additional, Del Fabro, Vittorio, additional, Sapienza, Giuseppe, additional, Martino, Enrica Antonia, additional, Parisi, Marina, additional, Calafiore, Valeria, additional, Di Raimondo, Francesco, additional, and Conticello, Concetta, additional

Published
2019
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7. Isavuconazole Prophylaxis during Early Phases of Allogeneic HSC Transplantation Is Not Associated to an Increase Need of Cyclosporin-a Dose Modification

Author

Cupri, Alessandra, primary, Leotta, Salvatore, additional, Markovic, Uros, additional, Camuglia, Maria Grazia, additional, Milone, Giulio Antonio, additional, Curto Pelle, Angelo, additional, Leotta, Valerio, additional, Di Giorgio, Mary Ann, additional, Bulla, Anna, additional, Anna Lia, Di Marco, additional, Moschetti, Gaetano, additional, and Milone, Giuseppe, additional

Published
2019
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8. Real-Rd - Real Life Italian Experience with Lenalidomide and Low-Dose Dexamethasone (Rd) As First Line Treatment of Newly-Diagnosed Multiple Myeloma Patients Not Eligible to Stem Cell Transplantation: Outcomes and Tolerability

Author

Pompa, Alessandra, primary, Conticello, Concetta, additional, Giannarelli, Diana, additional, Pettine, Loredana, additional, Paris, Laura, additional, Tognazzi, Lucia, additional, Marcatti, Magda, additional, Antonioli, Elisabetta, additional, Fioritoni, Francesca, additional, Bonalumi, Angela, additional, Mangiacavalli, Silvia, additional, Bertazzoni, Paola, additional, Vincelli, Iolanda Donatella, additional, Derudas, Daniele, additional, Siniscalchi, Agostina, additional, Pezzatti, Sara, additional, Zambello, Renato, additional, Citro, Annalisa, additional, Belotti, Angelo, additional, Lombardo, Alessandra, additional, Vozella, Federico, additional, Sementa, Adelina, additional, Consoli, Ugo, additional, Molteni, Alfredo, additional, Frungillo, Niccolò, additional, Gentile, Massimo, additional, Buda, Gabriele, additional, Aquino, Sara, additional, Palmieri, Salvatore, additional, Bongarzoni, Velia, additional, Inzoli, Alessandro, additional, Ferla, Valeria, additional, Rossi, Francesca Gaia, additional, Leotta, Valerio, additional, Romano, Alessandra, additional, Elia, Federica, additional, Del Fabro, Vittorio, additional, Montanaro, Guido, additional, Cavallaro, Francesca, additional, Galli, Monica, additional, and Baldini, Luca, additional

Published
2019
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9. Clinical Benefit of Long-Term Disease Control with Pomalidomide and Dexamethasone in Relapsed/Refractory Multiple Myeloma Patients

Author

Parisi, Marina Silvia, primary, Leotta, Salvatore, additional, Romano, Alessandra, additional, Del Fabro, Vittorio, additional, Martino, Enrica Antonia, additional, Calafiore, Valeria, additional, Giubbolini, Rachele, additional, Markovic, Uros, additional, Leotta, Valerio, additional, Di Giorgio, Mary Ann, additional, Tibullo, Daniele, additional, Di Raimondo, Francesco, additional, and Conticello, Concetta, additional

Published
2019
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10. Feasibility, Tolerability and Efficacy of Carfilzomib in Combination with Lenalidomide and Dexamethasone in Relapsed Refractory Myeloma Patients: A Retrospective Real-Life Survey of the Sicilian Myeloma Network

Author

Conticello, Concetta, primary, Romano, Alessandra, additional, Del Fabro, Vittorio, additional, Martino, Enrica Antonia, additional, Calafiore, Valeria, additional, Sapienza, Giuseppe, additional, Leotta, Valerio, additional, Parisi, Marina Silvia, additional, Markovic, Uros, additional, Garibaldi, Bruno, additional, Leotta, Salvatore, additional, Cotzia, Emilia, additional, Innao, Vanessa, additional, Mannina, Donato, additional, Neri, Santo, additional, Musso, Maurizio, additional, Scalone, Renato, additional, Cangialosi, Clotilde, additional, Acquaviva, Francesco, additional, Cardinale, Giovanni, additional, Merenda, Anxur, additional, Maugeri, Cinzia, additional, Uccello, Giuseppina, additional, Poidomani, Massimo, additional, Longo, Giuseppe, additional, Carlisi, Melania, additional, Tibullo, Daniele, additional, and Di Raimondo, Francesco, additional

Published
2019
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11. Pomalidomide-Responsive Extramedullary Myeloma Relapsed after Allogeneic Hematopoietic Transplant and Refractory to Multiple Lines of Chemotherapy

Author

Leotta, Salvatore, primary, Pirosa, Maria Cristina, additional, Markovic, Uros, additional, Scalise, Luca, additional, Bulla, Anna, additional, Sapienza, Giuseppe, additional, Di Giorgio, Mary Ann, additional, Martino, Enrica Antonia, additional, Curto Pelle, Angelo, additional, Leotta, Valerio, additional, Milone, Giulio, additional, Cupri, Alessandra, additional, Vaddinelli, Doriana, additional, Villari, Loredana, additional, Conticello, Concetta, additional, and Milone, Giuseppe, additional

Published
2019
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12. The Combined Evaluation of Neutrophil, T-Lymphocyte and Monocyte Counts Provides New Prognostic Information in CLL Patients

Author

Chiarenza, Annalisa, primary, Parrinello, Nunziatina Laura, additional, Triolo, Anna Maria, additional, Rizzo, Giuseppina, additional, Romano, Alessandra, additional, Maugeri, Cinzia, additional, Caruso, Laura Anastasia, additional, Motta, Giovanna, additional, Figuera, Amalia, additional, Curto Pelle, Angelo, additional, Leotta, Valerio, additional, Di Giorgio, Mary Ann, additional, La Cava, Piera, additional, Giallongo, Cesarina, additional, Tibullo, Daniele, additional, and Di Raimondo, Francesco, additional

Published
2016
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13. Neutrophil to T-Lymphocyte Ratio (NLR) and Neutrophil to Monocyte Ratio (NMR) Are Promising Biomarkers in Chronic Lymphocytic Leukemia Prognostic Assessment

Author

Chiarenza, Annalisa, Di Raimondo, Francesco, Parrinello, Nunziatina Laura, Triolo, Anna, Rizzo, Giuseppina, Curto Pelle, Angelo, Maugeri, Cinzia, Caruso, Anastasia Laura, Motta, Giovanna, Figuera, Amalia, Romano, Alessandra, Leotta, Valerio, Di Giorgio, Mary Ann, Giallongo, Cesarina, and Tibullo, Daniele

Published
2017
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14. Plasticity of High-Density Neutrophils in Multiple Myeloma is Associated with Increased Autophagy Via STAT3.

Author

Puglisi, Fabrizio, Parrinello, Nunziatina Laura, Giallongo, Cesarina, Cambria, Daniela, Camiolo, Giuseppina, Bellofiore, Claudia, Conticello, Concetta, Del Fabro, Vittorio, Leotta, Valerio, Markovic, Uros, Sapienza, Giuseppe, Barbato, Alessandro, Scalese, Silvia, Tibullo, Daniele, Brundo, Maria Violetta, Palumbo, Giuseppe Alberto, Di Raimondo, Francesco, and Romano, Alessandra

Subjects
NEUTROPHILS, MULTIPLE myeloma, BONE marrow, BACTERIAL diseases, LEUCOCYTES
Abstract

In both monoclonal gammopathy of uncertain significance (MGUS) and multiple myeloma (MM) patients, immune functions are variably impaired, and there is a high risk of bacterial infections. Neutrophils are the most abundant circulating leukocytes and constitute the first line of host defense. Since little is known about the contribution of autophagy in the neutrophil function of MGUS and MM patients, we investigated the basal autophagy flux in freshly sorted neutrophils of patients and tested the plastic response of healthy neutrophils to soluble factors of MM. In freshly sorted high-density neutrophils obtained from patients with MGUS and MM or healthy subjects, we found a progressive autophagy trigger associated with soluble factors circulating in both peripheral blood and bone marrow, associated with increased IFNγ and pSTAT3S727. In normal high-density neutrophils, the formation of acidic vesicular organelles, a morphological characteristic of autophagy, could be induced after exposure for three hours with myeloma conditioned media or MM sera, an effect associated with increased phosphorylation of STAT3-pS727 and reverted by treatment with pan-JAK2 inhibitor ruxolitinib. Taken together, our data suggest that soluble factors in MM can trigger contemporary JAK2 signaling and autophagy in neutrophils, targetable with ruxolitinib. [ABSTRACT FROM AUTHOR]

Published
2019
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