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1. Age- and sex-based heterogeneity in coronary artery plaque presence and burden in familial hypercholesterolemia: A multi-national study

Author

Khurram Nasir, Reed Mszar, Miguel Cainzos-Achirica, Gowtham R. Grandhi, Tycho R. Tromp, Rodrigo Alonso, Márcio S. Bittencourt, Eric Bruckert, José Luis Díaz-Díaz, Antonio Gallo, G. Kees Hovingh, Marcio H. Miname, Ovidio Muñiz-Grijalvo, Jing Pang, Leopoldo Perez de Isla, Eric J.G. Sijbrands, Gerald F. Watts, Pedro Mata, and Raul D. Santos

Subjects
Atherosclerotic cardiovascular disease, Coronary artery calcium, Familial hypercholesterolemia, Low-density lipoprotein cholesterol, Plaque burden, Diseases of the circulatory (Cardiovascular) system, RC666-701, Public aspects of medicine, RA1-1270
Abstract

Objectives: Individuals with familial hypercholesterolemia (FH) are at an increased risk for coronary artery disease (CAD). While prior research has shown variability in coronary artery calcification (CAC) among those with FH, studies with small sample sizes and single-center recruitment have been limited in their ability to characterize CAC and plaque burden in subgroups based on age and sex. Understanding the spectrum of atherosclerosis may result in personalized risk assessment and tailored allocation of costly add-on, non-statin lipid-lowering therapies. We aimed to characterize the presence and burden of CAC and coronary plaque on computed tomography angiography (CTA) across age- and sex-stratified subgroups of individuals with FH who were without CAD at baseline. Methods: We pooled 1,011 patients from six cohorts across Brazil, France, the Netherlands, Spain, and Australia. Our main measures of subclinical atherosclerosis included CAC ranges (i.e., 0, 1–100, 101–400, >400) and CTA-derived plaque burden (i.e., no plaque, non-obstructive CAD, obstructive CAD). Results: Ninety-five percent of individuals with FH (mean age: 48 years; 54% female; treated LDL-C: 154 mg/dL) had a molecular diagnosis and 899 (89%) were on statin therapy. Overall, 423 (42%) had CAC=0, 329 (33%) had CAC 1–100, 160 (16%) had CAC 101–400, and 99 (10%) had CAC >400. Compared to males, female patients were more likely to have CAC=0 (48% [n = 262] vs 35% [n = 161]) and no plaque on CTA (39% [n = 215] vs 26% [n = 120]). Among patients with CAC=0, 85 (20%) had non-obstructive CAD. Females also had a lower prevalence of obstructive CAD in CAC 1–100 (8% [n = 15] vs 18% [n = 26]), CAC 101–400 (32% [n = 22] vs 40% [n = 36]), and CAC >400 (52% [n = 16] vs 65% [n = 44]). Female patients aged 50–59 years were less likely to have obstructive CAD in CAC >400 (55% [n = 6] vs 70% [n = 19]). Conclusion: In this large, multi-national study, we found substantial age- and sex-based heterogeneity in CAC and plaque burden in a cohort of predominantly statin-treated individuals with FH, with evidence for a less pronounced increase in atherosclerosis among female patients. Future studies should examine the predictors of resilience to and long-term implications of the differential burden of subclinical coronary atherosclerosis in this higher risk population.

Published
2024
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2. Hiperlipidemia familiar combinada: documento de consenso

Author

Pedro Mata, Rodrigo Alonso, Antonio Ruíz-Garcia, Jose L. Díaz-Díaz, Noemí González, Teresa Gijón-Conde, Ceferino Martínez-Faedo, Ignacio Morón, Ezequiel Arranz, Rocío Aguado, Rosa Argueso, and Leopoldo Perez de Isla

Subjects
Hiperlipidemia familiar combinada, Enfermedad cardiovascular, Diabetes mellitus tipo 2, Hipertensión, Tratamiento hipolipemiante, Documento de consenso, Medicine (General), R5-920
Abstract

La hiperlipidemia familiar combinada (HFC) es un trastorno muy frecuente asociado a enfermedad coronaria prematura. Se transmite de forma autosómica dominante, aunque no existe un gen único asociado al trastorno. El diagnóstico se realiza mediante criterios clínicos, y son importantes la variabilidad del fenotipo lipídico y la historia familiar de hiperlipidemia. Es frecuente la asociación con diabetes mellitus tipo 2, hipertensión arterial y obesidad central. Los pacientes con HFC se consideran de riesgo cardiovascular alto y el objetivo terapéutico es un colesterol-LDL

Published
2014
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4. Association of BMI, lipid-lowering medication, and age with prevalence of type 2 diabetes in adults with heterozygous familial hypercholesterolaemia: a worldwide cross-sectional study

Author

Elshorbagy, Amany, Lyons, Alexander R.M., Vallejo-Vaz, Antonio J., Stevens, Christophe A.T., Dharmayat, Kanika I., Brandts, Julia, Catapano, Alberico L., Freiberger, Tomas, Hovingh, G. Kees, Mata, Pedro, Raal, Frederick J., Santos, Raul D., Soran, Handrean, Watts, Gerald F., Abifadel, Marianne, Aguilar-Salinas, Carlos A., Alhabib, Khalid F., Alkhnifsawi, Mutaz, Almahmeed, Wael, Alonso, Rodrigo, Al-Rasadi, Khalid, Al-Sarraf, Ahmad, Ashavaid, Tester F., Banach, Maciej, Binder, Christoph J., Bourbon, Mafalda, Brunham, Liam R., Chlebus, Krzysztof, Corral, Pablo, Cruz, Diogo, Davletov, Kairat, Descamps, Olivier S., Ezhov, Marat, Gaita, Dan, Groselj, Urh, Harada-Shiba, Mariko, Holven, Kirsten B., Kayikcioglu, Meral, Khovidhunkit, Weerapan, Lalic, Katarina, Latkovskis, Gustavs, Laufs, Ulrich, Liberopoulos, Evangelos, Lima-Martinez, Marcos M., Lin, Jie, Maher, Vincent, Marais, A. David, März, Winfried, Mirrakhimov, Erkin, Miserez, André R., Mitchenko, Olena, Nawawi, Hapizah, Nordestgaard, Børge G., Panayiotou, Andrie G., Paragh, György, Petrulioniene, Zaneta, Pojskic, Belma, Postadzhiyan, Arman, Reda, Ashraf, Reiner, Željko, Reyes, Ximena, Sadiq, Fouzia, Sadoh, Wilson E., Schunkert, Heribert, Shek, Aleksandr B., Stroes, Erik, Su, Ta-Chen, Subramaniam, Tavintharan, Susekov, Andrey V., Tilney, Myra, Tomlinson, Brian, Truong, Thanh-Huong, Tselepis, Alexandros D., Tybjærg-Hansen, Anne, Vázquez, Alejandra C., Viigimaa, Margus, Vohnout, Branislav, Wang, Luya, Yamashita, Shizuya, Arca, Marcello, Averna, Maurizio, Schreier, Laura, Pang, Jing, Ebenbichler, Christoph, Dieplinger, Hans, Innerhofer, Reinhold, Winhofer-Stöckl, Yvonne, Greber-Platzer, Susanne, Krychtiuk, Konstantin, Speidl, Walter, Toplak, Hermann, Widhalm, Kurt, Stulnig, Thomas, Huber, Kurt, Höllerl, Florian, Rega-Kaun, Gersina, Kleemann, Lucas, Mäser, Martin, Scholl-Bürgi, Sabine, Säly, Christoph, Mayer, Florian J., Sperone, Alexandra, Tanghe, Chloé, Gérard, Anne-Catherine, Pojskic, Lamija, Sisic, Ibrahim, Durak Nalbantic, Azra, Ejubovic, Malik, Jannes, Cinthia E., Pereira, Alexandre C., Krieger, Jose E., Petrov, Ivo, Goudev, Assen, Nikolov, Fedya, Tisheva, Snejana, Yotov, Yoto, Tzvetkov, Ivajlo, Baass, Alexis, Bergeron, Jean, Bernard, Sophie, Brisson, Diane, Cermakova, Lubomira, Couture, Patrick, Francis, Gordon A., Gaudet, Daniel, Hegele, Robert A., Khoury, Etienne, Mancini, G.B. John, McCrindle, Brian W., Paquette, Martine, Ruel, Isabelle, Iatan, Iulia, Cuevas, Ada, Wang, Xumin, Meng, Kang, Song, Xiantao, Yong, Qiang, Jiang, Tao, Liu, Ziyou, Duan, Yanyu, Hong, Jing, Ye, Pucong, Chen, Yan, Qi, Jianguang, Liu, Zesen, Li, Yuntao, Zhang, Chaoyi, Peng, Jie, Yang, Ya, Yu, Wei, Wang, Qian, Yuan, Hui, Cheng, Shitong, Jiang, Long, Chong, Mei, Jiao, Jian, Wu, Yue, Wen, Wenhui, Xu, Liyuan, Zhang, Ruiying, Qu, Yichen, He, Jianxun, Fan, Xuesong, Wang, Zhenjia, Chow, Elaine, Pećin, Ivan, Perica, Dražen, Symeonides, Phivos, Vrablik, Michal, Ceska, Richard, Soska, Vladimir, Tichy, Lukas, Adamkova, Vera, Franekova, Jana, Cifkova, Renata, Kraml, Pavel, Vonaskova, Katerina, Cepova, Jana, Dusejovska, Magdalena, Pavlickova, Lenka, Blaha, Vladimir, Rosolova, Hana, Nussbaumerova, Barbora, Cibulka, Roman, Vaverkova, Helena, Cibickova, Lubica, Krejsova, Zdenka, Rehouskova, Katerina, Malina, Pavel, Budikova, Milena, Palanova, Vaclava, Solcova, Lucie, Lubasova, Alena, Podzimkova, Helena, Bujdak, Juraj, Vesely, Jiri, Jordanova, Marta, Salek, Tomas, Urbanek, Robin, Zemek, Stanislav, Lacko, Jan, Halamkova, Hana, Machacova, Sona, Mala, Sarka, Cubova, Eva, Valoskova, Katerina, Burda, Lukas, Benn, Marianne, Bendary, Ahmed, Daoud, Ihab, Emil, Sameh, Elbahry, Atef, Rafla, Samir, Sanad, Osama, Kazamel, Ghada, Ashraf, Dr Mohamed, Sobhy, Mohamed, El-Hadidy, Amro, Shafy, Mohamed Abdoul, Kamal, Saif, Bendary, Mohamed, Talviste, Grete, Christmann, Jutta, Dressel, Alexander, Fath, Felix, Ferraro, Chiara, Frenzke, Lydia, Gopon, Alica, Klein, Isabel, Pienkowska, Dominika, Sietmann, Tobias, Sonntag, Antonia, Adjan, Omar, Bahrmann, Philipp, Baessler, Andrea, Barkowski, Rasmus, Beckerdjian, Raffi, Berr, Christina, Birkenfeld, Andreas, Böll, Gereon, Carstensen, Avisha, Demuth, Ilya, Finkernagel, Holger, Gouni-Berthold, Ioanna, Hahmann, Harry, Hamerle, Michael, Halder, Julian, Heide, Maria, Julius, Ulrich, Kassner, Ursula, Katzmann, Julius L, Kirschbaum, Anja, Klose, Gerald, Könemann, Stephanie, König, Christel, König, Wolfgang, Krämer, Bernhard, Kuprat, Gerrit, Koschker, Ann-Cathrin, Kilic, Özlem, Lindenmeier, Gerd, Van de Loo, Iris, Lorenz, Babette, Lorenz, Elke, Löhr, Birgit, McChord, Johanna, Maslarska, Mariya, Methe, Heiko, Merkel, Martin, Moussaoui, Zineb, Müller-Kozarez, Irina, Olivier, Christoph B, Ong, Peter, Otte, Britta, Parhofer, Klaus, Partsch, Carl-Joachim, Paulus, Michael, Pehlivanli, Sinan, Pflederer, Tobias, Pusl, Thomas, Richter, Veronika, Rosner, Stefanie, Sanin, Veronika, Schäfer, Sebastian, Schäfer, Christoph, Schatz, Ulrike, Schirmer, Stephan, Schmidt, Christine, Seeger, Wolfgang, Sisovic, Snezna, Spens, Antje, Jablonski, Ksenija Stach, Stadelmann, Alexander, Steinhagen-Thiessen, Elisabeth, Stürzebecher, Paulina, Tafelmeier, Maria, Tillack, Dörthe, Tselmin, Sergey, Tünnemann-Tarr, Adrienn, Vogt, Anja, Beckerath, Jens von, Wilke, Andreas, Wolf, Ulrich, Zemmrich, Claudia, Rizos, Christos V., Skoumas, Ioannis, Tziomalos, Konstantinos, Rallidis, Loukianos, Kotsis, Vasileios, Doumas, Michalis, Athyros, Vasileios, Skalidis, Emmanouil, Kolovou, Genovefa, Kolovou, Vana, Garoufi, Anastasia, Bilianou, Eleni, Koutagiar, Iosif, Kiouri, Estela, Antza, Christina, Zacharis, Evangelos, Attilakos, Achilleas, Sfikas, George, Koumaras, Charalambos, Anagnostis, Panagiotis, Anastasiou, Georgia, Liamis, George, Koutsogianni, Amalia-Despoina, Petkou, Ermioni, Milionis, Haralambos, Koulouri, Anastasia, Prodromiadou, Elisavet, Karányi, Zsolt, Harangi, Mariann, Bajnok, László, Audikovszky, Mária, Márk, László, Benczúr, Béla, Reiber, István, Nagy, Gergely, Nagy, András, Reddy, Lakshmi Lavanya, Shah, Swarup A. V, Ponde, Chandrashekhar K., Dalal, Jamshed J., Sawhney, Jitendra P.S., Verma, Ishwar C., Altaey, Mays, Al-Jumaily, Khalid, Rasul, Dilshad, Abdalsahib, Ali Fawzi, Jabbar, Amer Abdl, Al-ageedi, Mohanad, Dhamin, Mohammed, AlFil, Sarmad, Khadhim, Foad, Miahy, Sabah, Agar, Ruth, Catapano, Alberico Luigi, Calandra, Sebastiano, Tarugi, Patrizia, Casula, Manuela, Galimberti, Federica, Olmastroni, Elena, Sarzani, Riccardo, Ferri, Claudio, Repetti, Elena, Piro, Salvatore, Suppressa, Patrizia, Meregalli, Giancarla, Borghi, Claudio, Muntoni, Sandro, Calabrò, Paolo, Cipollone, Francesco, Purrello, Francesco, Pujia, Arturo, Passaro, Angelina, Marcucci, Rossella, Pecchioli, Valerio, Pisciotta, Livia, Mandraffino, Giuseppe, Pellegatta, Fabio, Mombelli, Giuliana, Branchi, Adriana, Fiorenza, Anna Maria, Pederiva, Cristina, Werba, Josè Pablo, Parati, Gianfranco, Carubbi, Francesca, Iughetti, Lorenzo, Fortunato, Giuliana, Iannuzzi, Arcangelo, Iannuzzo, Gabriella, Cefalù, Angelo Baldassare, Biasucci, Giacomo, Zambon, Sabina, Pirro, Matteo, Sbrana, Francesco, Trenti, Chiara, D'Erasmo, Laura, Federici, Massimo, Ben, Maria Del, Bartuli, Andrea, Giaccari, Andrea, Pipolo, Antonio, Citroni, Nadia, Guardamagna, Ornella, Lia, Salvatore, Benso, Andrea, Biolo, Gianni, Maroni, Lorenzo, Lupi, Alessandro, Bonanni, Luca, Rinaldi, Elisabetta, Zenti, Maria Grazia, Matsuki, Kota, Hori, Mika, Ogura, Masatsune, Masuda, Daisaku, Kobayashi, Takuya, Nagahama, Kumiko, Al-Jarallah, Mohammed, Radovic, Mirjana, Lunegova, Olga, Bektasheva, Erkayim, Abilova, Saamay, Erglis, Andrejs, Gilis, Dainus, Nesterovics, Georgijs, Saripo, Vita, Meiere, Ruta, Skudrina, Gunda, Terauda, Elizabete, Jambart, Selim, Ayoub, Carine, Ghaleb, Youmna, Aliosaitiene, Urte, Kutkiene, Sandra, Abdul Kadir, Siti Hamimah Sheikh, Kasim, Noor Alicezah Mohd, Nor, Noor Shafina Mohd, Abdul Hamid, Hasidah, Abdul Razak, Suraya, Al-Khateeb, Alyaa, Abd Muid, Suhaila, Abdul Rahman, Thuhairah, Kasim, Sazzli Shahlan, Radzi, Ahmad Bakhtiar Md, Ibrahim, Khairul Shafiq, Rosli, Marshima Mohd, Razali, Rafezah, Chua, Yung An, Razman, Aimi Zafira, Nazli, Sukma Azureen, Aziz, Nazirul, Rosman, Azhari, Abdul Murad, NorAzian, Jalaludin, Mohd Amin, Abdul Latif, Ahmad Zubaidi, Azzopardi, C., Mehta, Roopa, Martagon, Alexandro J., Ramirez, Gabriela A. Galan, Villa, Neftali E Antonio, Vazquez, Arsenio Vargas, Elias-Lopez, Daniel, Retana, Gustavo Gonzalez, Rodriguez, Betsabel, Macías, Jose J. Ceballos, Zazueta, Alejandro Romero, Alvarado, Rocio Martinez, Portano, Julieta D. Morales, Lopez, Humberto Alvares, Sauque-Reyna, Leobardo, Herrera, Laura G. Gomez, Mendia, Luis E. Simental, Aguilar, Humberto Garcia, Cooremans, Elizabeth Ramirez, Aparicio, Berenice Peña, Zubieta, Victoria Mendoza, Gonzalez, Perla A. Carrillo, Ferreira-Hermosillo, Aldo, Portilla, Nacu Caracas, Dominguez, Guadalupe Jimenez, Garcia, Alinna Y. Ruiz, Cazares, Hector E. Arriaga, Gonzalez, Jesus R., Valencia, Carla V. Mendez, Padilla, Francisco G., Prado, Ramon Madriz, Ibarra, Manuel O. De los Rios, Villicaña, Ruy D. Arjona, Rivera, Karina J. Acevedo, Carrera, Ricardo Allende, Alvarez, Jose A., Martinez, Jose C. Amezcua, Bustillo, Manuel de los Reyes Barrera, Vargas, Gonzalo Carazo, Chacon, Roberto Contreras, Andrade, Mario H. Figueroa, Ortega, Ashanty Flores, Alcala, Hector Garcia, de Leon, Laura E. Garcia, Guzman, Berenice Garcia, Garcia, Jose J. Garduño, Cuellar, Juan C. Garnica, Cruz, Jose R. Gomez, Garcia, Anell Hernandez, Almada, Jesus R. Holguin, Herrera, Ursulo Juarez, Sobrevilla, Fabiola Lugo, Rodriguez, Eduardo Marquez, Sibaja, Cristina Martinez, Rodriguez, Alma B. Medrano, Oyervides, Jose C. Morales, Vazquez, Daniel I. Perez, Rodriguez, Eduardo A. Reyes, Osorio, Ma. Ludivina Robles, Saucedo, Juan Rosas, Tamayo, Margarita Torres, Talavera, Luis A. Valdez, Arroyo, Luis E. Vera, Carrillo, Eloy A. Zepeda, Stroes, Erik S, Defesche, J, Zuurbier, L, Reeskamp, L, Ibrahim, S, Roeters van Lennep, Jeanine, Wiegman, Albert, Isara, Alphonsus, Obaseki, Darlington E., Al-Waili, Khalid, Al-Zadjali, Fahad, Al-Zakwani, Ibrahim, Al-Kindi, Mohammed, Al-Mukhaini, Suad, Al-Barwani, Hamida, Rana, Asim, Shah, Lahore Saeed Ullah, Al-Nouri, Fahad, Starostecka, Ewa, Konopka, Agnieszka, Bielecka-Dabrowa, Agata, Lewek, Joanna, Sosnowska, Bozena, Gąsior, Mariusz, Dyrbuś, Krzysztof, Jóźwiak, Jacek, Pajkowski, Marcin, Romanowska-Kocejko, Marzena, Żarczyńska-Buchowiecka, Marta, Chmara, Magdalena, Wasąg, Bartosz, Stróżyk, Aneta, Michalska-Grzonkowska, Aleksandra, Medeiros, Ana Margarida, Alves, Ana Catarina, Silva, Francisco, Lobarinhas, Goreti, Palma, Isabel, de Moura, Jose Pereira, Rico, Miguel Toscano, Rato, Quitéria, Pais, Patrícia, Correia, Susana, Moldovan, Oana, Virtuoso, Maria João, Araujo, Francisco, Salgado, Jose Miguel, Colaço, Ines, Dumitrescu, Andreea, Lengher, Calin, Mosteoru, Svetlana, Meshkov, Alexey, Ershova, Alexandra, Rozhkova, Tatiana, Korneva, Victoria, Yu, Kuznetsova T., Zafiraki, Vitaliy, Voevoda, Mikhail, Gurevich, Victor, Duplyakov, Dmitry, Ragino, Yulia, Chubykina, Uliana, Shaposhnik, Igor, Alkaf, Fahmi, Khudari, Alia, Rwaili, Nawal, Al-Allaf, Faisal, Alghamdi, Mohammad, Batais, Mohammed A, Almigbal, Turky H, Kinsara, Abdulhalim, AlQudaimi, Ashraf Hammouda Ahmed, Awan, Zuhier, Elamin, Omer A, Altaradi, Hani, Popovic, Ljiljana, Singh, Sandra, Rasulic, Iva, Petakov, Ana, Lalic, Nebojsa M., Lam, Carolyn, Le, Tan Ju, Siang, Eric Lim Tien, Dissanayake, Sanjaya, I-Shing, Justin Tang, Shyong, Tai E, Jin, Terrance Chua Siang, Ting, Sharon Pek Li, Ming, Jeremy Hoe Kian, Drum, Chester Lee, Nastar, Fathima Ashna, Jia, Loh Wann, Ya, Natalie Koh Si, Jie, Marvin Chua Wei, Dalan, Rinkoo, Wei, Yong Quek, sian, Tiong Yee, Keong, Yeo Khung, Rong, Siau Kai, Jin, Darren Seah Ee, Ming, Ian Koh Jan, Chang, Tan Hong, Peng, Fabian Yap Kok, Vasanwala, Rashida Farhad, Raslova, Katarina, Balinth, Karin, Buganova, Ingrid, Fabryova, Lubomira, Kadurova, Michaela, Klabnik, Alexander, Kozárová, Miriam, Sirotiakova, Jana, Battelino, Tadej, Cevc, Matija, Debeljak, Marusa, Torkar, Ana Drole, Fras, Zlatko, Jug, Borut, Cugalj, Barbara Kern, Kovac, Jernej, Mlinaric, Matej, Sikonja, Jaka, Pilcher, Gillian Joan, Blom, D J, Wolmarans, K H, Brice, B C, Muñiz-Grijalvo, Ovidio, Díaz-Díaz, Jose Luis, de Isla, Leopoldo Pérez, Fuentes, Francisco, Badimon, Lina, Martin, François, Miserez, Eleonore B., Shipton, Janine L., Ganokroj, Poranee, Chattranukulchai, Pairoj, Jiamjarasrungsi, Wiroj, Thongtang, Nuntakorn, Krittayaphong, Rungroj, Vathesatogkit, Prin, Sriphrapradang, Chutintorn, Phimphilai, Mattabhorn, Leelawattana, Rattana, Anthanont, Pimjai, Suraamornkul, Swangjit, Deerochanawong, Chaicharn, Senthong, Vichai, Torpongpun, Artit, Suteerayongprasert, Panuwat, Pengpong, Nawarat, Sathavarodom, Nattapol, Sunanta, Usanee, Porntharukchareon, Thachanun, Kiatpanabhikul, Phatharaporn, Kaewkrasaesin, Chatchon, Kongkit, Jaruwan, Umphonsathien, Mongkontida, Akbulut, Mehmet, Alici, Gökhan, Bayram, Fahri, Can, Levent Hürkan, Celik, Ahmet, Ceyhan, Ceyhun, Coskun, Fatma Yilmaz, Demir, Mesut, Demircan, Sabri, Dogan, Volkan, Durakoglugil, Emre, Dural, İbrahim Etem, Gedikli, Omer, Hacioglu, Aysa, Ildizli, Muge, Kilic, Salih, Kirilmaz, Bahadir, Kutlu, Merih, Oguz, Aytekin, Ozdogan, Oner, Onrat, Ersel, Ozer, Savas, Sabuncu, Tevfik, Sahin, Tayfun, Sivri, Fatih, Sonmez, Alper, Temizhan, Ahmet, Topcu, Selim, Tokgozoglu, Lale, Tuncez, Abdullah, Vural, Mirac, Yenercag, Mustafa, Yesilbursa, Dilek, Yigit, Zerrin, Yildirim, Aytul Belgi, Yildirir, Aylin, Yilmaz, Mehmet Birhan, Atallah, Bassam, Traina, Mahmoud, Sabbour, Hani, Abdul Hay, Dana, Luqman, Neama, Elfatih, Abubaker, Abdulrasheed, Arshad, Manla, Yosef, Kwok, See, DellOca, Nicolas, Alieva, Rano B., Fozilov, Khurshid G., Hoshimov, Shavkat U., Nizamov, Ulugbek I., Kan, Liliya E., Kim, Andrey R., Abdullaeva, Guzal J., Abdullaev, Alisher A., Do, Doan Loi, Nguyen, Mai Ngoc Thi, Kim, Ngoc Thanh, Le, Thanh Tung, Le, Hong An, and Ray, Kausik K.

Published
2024
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5. Long-term sex differences in atherosclerotic cardiovascular disease in individuals with heterozygous familial hypercholesterolaemia in Spain: a study using data from SAFEHEART, a nationwide, multicentre, prospective cohort study

Author

de Isla, Leopoldo Pérez, Vallejo-Vaz, Antonio J, Watts, Gerald F, Muñiz-Grijalvo, Ovidio, Alonso, Rodrigo, Diaz-Diaz, Jose L, Arroyo-Olivares, Raquel, Aguado, Rocio, Argueso, Rosa, Mauri, Marta, Romero, Manuel J, Álvarez-Baños, Pilar, Mañas, Dolores, Cepeda, José María, Gonzalez-Bustos, Pablo, Casañas, Marta, Michan, Alfredo, Muñoz-Torrero, Juan F Sánchez, Faedo, Ceferino, Barba, Miguel A, Dieguez, Marta, de Andrés, Raimundo, Hernandez, Antonio M, Gonzalez-Estrada, Aurora, Padró, Teresa, Fuentes, Francisco, Badimon, Lina, and Mata, Pedro

Published
2024
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6. Iatrogenic pathology of the aorta after interventional cardiology procedures

Author

Jose Alberto de Agustin, Jose Juan Gomez de Diego, Patricia Mahia, Pedro Marcos-Alberca, Carlos Almeria, Jose Luis Rodrigo, Maria Luaces, Ivan Javier Nunez-Gil, Carlos Macaya, and Leopoldo Perez de Isla

Subjects
Aorta Artery, Iatrogenic Disease, Dissection, Aortic Rupture, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Context: In this review, we tried to evaluate the incidence, prognosis and treatment options in patients with iatrogenic pathology of the aortic artery due to interventional procedures in cardiology. Evidence Acquisition: Our search strategy involved an investigation in the PUBMED database for every available article in peer reviewed journals between 1975 and 2015, for subjects related to iatrogenic pathology of the aortic artery, following interventional procedures in cardiology (coronary angiography or angioplasty, trans-catheter aortic valve implantation (TAVI) or intra-aortic balloon pump (IABP) counterpulsation placement). Results: Iatrogenic pathology of the aorta is a rare, but potentially lethal complication of invasive vascular techniques. The development of these complications should be considered in cases of unexplained hypotension, acidosis or lower limb ischemia after catheter-based interventions. With increased experience, most of the vascular complications associated with the transfemoral approach may be managed percutaneously. Conclusions: With the increase in interventional procedures in cardiology, iatrogenic pathology of the aorta is seen more frequently, and every cardiologist should know how to diagnose and treat this group of diseases.

Published
2016
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7. Age- and sex-based heterogeneity in coronary artery plaque presence and burden in familial hypercholesterolemia: A multi-national study

Author

Nasir, Khurram, Mszar, Reed, Cainzos-Achirica, Miguel, Grandhi, Gowtham R., Tromp, Tycho R., Alonso, Rodrigo, Bittencourt, Márcio S., Bruckert, Eric, Díaz-Díaz, José Luis, Gallo, Antonio, Hovingh, G. Kees, Miname, Marcio H., Muñiz-Grijalvo, Ovidio, Pang, Jing, de Isla, Leopoldo Perez, Sijbrands, Eric J.G., Watts, Gerald F., Mata, Pedro, and Santos, Raul D.

Published
2024
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9. The Added Value of Coronary Calcium Score in Predicting Cardiovascular Events in Familial Hypercholesterolemia

Author

Angoulvant, Denis, Beliard, Sophie, Boccara, Franck, Bruckert, Eric, Cariou, Bertrand, Carreau, Valérie, Carrie, Alain, Charrieres, Sybil, Cottin, Yves, Di Filippo, Mathilde, Ducluzeau, Pierre Henri, Dulong, Sonia, Durlach, Vincent, Farnier, Michel, Ferrari, Emile, Ferrieres, Dorota, Ferrieres, Jean, Gallo, Antonio, Giral, Philippe, Gonbert, Sophie, Hankard, Regis, Inamo, Jocelyn, Kalmykova, Olga, Krempf, Michel, Lemale, Julie, Moulin, Philippe, Paillard, François, Peretti, Noel, Perrin, Agnes, Pradignac, Alain, Rabes, Jean Pierre, Rigalleau, Vincent, Schiele, François, Sultan, Ariane, Tounian, Patrick, Valero, René, Verges, Bruno, Yelnik, Cecile, Ziegler, Olivier, Aguado, Rocío, Alonso, Rodrigo, Álvarez-Baños, M<ce:sup loc='post">a</ce:sup> Pilar, Argüeso, Rosa, Arrieta, Francisco, Barba, Miguel Ángel, Casañas, Marta, Cepeda, José María, De Andrés, Raimundo, Díaz-Soto, Gonzalo, Díaz-Diaz, Jose Luis, Dieguez, Marta, Faedo, Ceferino, Fuentes, Francisco, Garrido, Juan A., González, Aurora, González-Bustos, Pablo, Mañas, M<ce:sup loc='post">a</ce:sup> Dolores, Mata, Pedro, Mauri, Marta, Mediavilla, Juan Diego, Michán, Alfredo, Miramontes, Pablo, Muñiz, Ovidio, Pérez, Leire, De Isla, Leopoldo Perez, Pintó, Xavier, Romero, Manuel J., Rubio, Patricia, Sánchez Muñoz-Torrero, Juan F., Vidal-Pardo, Jose I., Zambón, Daniel, Pérez de Isla, Leopoldo, Charrière, Sybil, Vimont, Alexandre, Muñiz-Grijalvo, Ovidio, Díaz-Díaz, José L., and Béliard, Sophie

Published
2021
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10. Age- and sex-based heterogeneity in coronary artery plaque presence and burden in familial hypercholesterolemia:A multi-national study

Author

Nasir, Khurram, Mszar, Reed, Cainzos-Achirica, Miguel, Grandhi, Gowtham R., Tromp, Tycho R., Alonso, Rodrigo, Bittencourt, Márcio S., Bruckert, Eric, Díaz-Díaz, José Luis, Gallo, Antonio, Hovingh, G. Kees, Miname, Marcio H., Muñiz-Grijalvo, Ovidio, Pang, Jing, de Isla, Leopoldo Perez, Sijbrands, Eric J.G., Watts, Gerald F., Mata, Pedro, Santos, Raul D., Nasir, Khurram, Mszar, Reed, Cainzos-Achirica, Miguel, Grandhi, Gowtham R., Tromp, Tycho R., Alonso, Rodrigo, Bittencourt, Márcio S., Bruckert, Eric, Díaz-Díaz, José Luis, Gallo, Antonio, Hovingh, G. Kees, Miname, Marcio H., Muñiz-Grijalvo, Ovidio, Pang, Jing, de Isla, Leopoldo Perez, Sijbrands, Eric J.G., Watts, Gerald F., Mata, Pedro, and Santos, Raul D.

Abstract

Objectives: Individuals with familial hypercholesterolemia (FH) are at an increased risk for coronary artery disease (CAD). While prior research has shown variability in coronary artery calcification (CAC) among those with FH, studies with small sample sizes and single-center recruitment have been limited in their ability to characterize CAC and plaque burden in subgroups based on age and sex. Understanding the spectrum of atherosclerosis may result in personalized risk assessment and tailored allocation of costly add-on, non-statin lipid-lowering therapies. We aimed to characterize the presence and burden of CAC and coronary plaque on computed tomography angiography (CTA) across age- and sex-stratified subgroups of individuals with FH who were without CAD at baseline. Methods: We pooled 1,011 patients from six cohorts across Brazil, France, the Netherlands, Spain, and Australia. Our main measures of subclinical atherosclerosis included CAC ranges (i.e., 0, 1–100, 101–400, >400) and CTA-derived plaque burden (i.e., no plaque, non-obstructive CAD, obstructive CAD). Results: Ninety-five percent of individuals with FH (mean age: 48 years; 54% female; treated LDL-C: 154 mg/dL) had a molecular diagnosis and 899 (89%) were on statin therapy. Overall, 423 (42%) had CAC=0, 329 (33%) had CAC 1–100, 160 (16%) had CAC 101–400, and 99 (10%) had CAC >400. Compared to males, female patients were more likely to have CAC=0 (48% [n = 262] vs 35% [n = 161]) and no plaque on CTA (39% [n = 215] vs 26% [n = 120]). Among patients with CAC=0, 85 (20%) had non-obstructive CAD. Females also had a lower prevalence of obstructive CAD in CAC 1–100 (8% [n = 15] vs 18% [n = 26]), CAC 101–400 (32% [n = 22] vs 40% [n = 36]), and CAC >400 (52% [n = 16] vs 65% [n = 44]). Female patients aged 50–59 years were less likely to have obstructive CAD in CAC >400 (55% [n = 6] vs 70% [n = 19]). Conclusion: In this lar

Published
2024

11. Incidencia de eventos cardiovasculares y cambios en el riesgo estimado y en el tratamiento de la hipercolesterolemia familiar: registro SAFEHEART

Author

Aguado, Rocío, Perez-Corral, Begoña, Almagro, Fátima, Alonso, Rodrigo, Arroyo, Raquel, Mata, Nelva, Mata, Pedro, Isla, Leopoldo Pérez de, Saltijeral, Adriana, Arrieta, Francisco, Badimón, Lina, Padró, Teresa, Barba, Miguel Ángel, Brea, Ángel, Mosquera, Daniel, Casañas, Marta, Carbayo, Julio, Cepeda, Jose María, De Andrés, Raimundo, Díaz, José L., Díaz-Soto, Gonzalo, Diéguez, Marta, Riestra, María, Fuentes, Francisco, López-Miranda, José, Galiana, Jesús, Mañas, M. Dolores, García-Cruces, Jesús, Garrido, Juan Antonio, Irigoyen, Luis, Martínez, Pedro L., Martínez-Faedo, Ceferino, Suárez, Lorena, Mauri, Marta, Borrallo, Rosa M., Mediavilla, Juan Diego, Jaén, Fernando, González, Pablo, Michán, Alfredo, Rubio, Patricia, Miramontes, Pablo, Morera, Juan L., Muñiz, Ovidio, González, Aurora, Pereyra, Francisca, Pérez, Leire, Piedecausa, Mar, Pastor, José, Pinilla, José Miguel, Pintó, Xavier, Romero, Manuel J., Ruiz, Enrique, Álvarez, M. Pilar, Sáenz, Pedro, Sánchez, Juan F., Sanz, Consuelo, Vidal, Jose I., Argüeso, Rosa, Zambón, Daniel, Pérez de Isla, Leopoldo, Arroyo-Olivares, Raquel, Muñiz-Grijalvo, Ovidio, Díaz-Díaz, José Luis, Sánchez Muñoz-Torrero, Juan F., Miramontes-González, José Pablo, de Andrés, Raimundo, Cepeda, José M., Vidal-Pardo, José I., Ruiz-Pérez, Enrique, Riestra Fernández, María, and Pinilla, José M.

Published
2020
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12. Age- and Sex-Based Heterogeneity in Coronary Artery Plaque Presence and Burden in Familial Hypercholesterolemia: A Multi-National Study

Author

Nasir, Khurram, primary, Mszar, Reed, additional, Cainzos-Achirica, Miguel, additional, Grandhi, Gowtham R., additional, Tromp, Tycho R., additional, Alonso, Rodrigo, additional, Bittencourt, Márcio S., additional, Bruckert, Eric, additional, Díaz-Díaz, José Luis, additional, Gallo, Antonio, additional, Hovingh, G. Kees, additional, Miname, Marcio H., additional, Muñiz-Grijalvo, Ovidio, additional, Pang, Jing, additional, de Isla, Leopoldo Perez, additional, Sijbrands, Eric J.G., additional, Watts, Gerald F., additional, Mata, Pedro, additional, and Santos, Raul D., additional

Published
2023
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15. Persistence with long-term PCSK9 inhibitor treatment and its effectiveness in familial hypercholesterolaemia: data from the SAFEHEART study

Author

Rodrigo Alonso, Raquel Arroyo-Olivares, Ovidio Muñiz-Grijalvo, Jose Luis Díaz-Díaz, Juan Sanchez Muñoz-Torrero, Manuel J Romero, Raimundo de Andrés, Daniel Zambón, María Dolores Mañas, Francisco Fuentes-Jiménez, Rocío Aguado, Pilar Alvarez-Baños, Francisco Arrieta, Pablo Gonzalez-Bustos, José Cepeda, Mercedes Martin-Ordiales, Daniel Mosquera, Alfredo Michan, Leopoldo Perez de Isla, Rosa Argueso, and Pedro Mata

Subjects
Epidemiology, Cardiology and Cardiovascular Medicine
Abstract

AimsMost heterozygous familial hypercholesterolaemia (FH) patients require intensive lipid-lowering therapy (LLT) including PCSK9 inhibitors (PCSK9is) to reach current low-density lipoprotein cholesterol (LDL-C) goals. Persistence with chronic treatment is important to reduce the burden of atherosclerotic cardiovascular disease. We analysed persistence, efficacy, and impact on quality of life (QoL) of PCSK9i in FH patients in clinical practice setting.Methods and resultsSpanish Familial Hypercholesterolaemia Cohort Study (SAFEHEART) is an open, prospective study in genetically defined FH patients in Spain. Patients ≥18 years of age (n = 696, 46% females) on stable LLT treated with PCSK9i were analysed. Median LDL-C at starting PCSK9i was 145 mg/dL [interquartile range (IQR), 123–177], 3.8 mmol/L (IQR 3.2–4.6). After a median follow up of 3.7 years (IQR 2.3–4.8), 27 patients (4%) discontinued PCSK9i treatment: 5 temporarily (0.7%) and 22 permanently (3.2%). Persistence with PCSK9i was 96.1% in the whole period. Median LDL-C levels and % LDL-C reduction attained after 1 year of treatment and in the last follow-up visit were 63 mg/dL (IQR 43–88), 1.6 mmol/L (IQR 1.1–2.23); 61 mg/dL (IQR 44–82), 1.6 mmol/L (IQR 1.1–2.1); 57.6% (IQR 39.5–69); and 58% (IQR 44–68), respectively. 2016 and 2019 ESC/EAS LDL-C goals were attained by 77 and 48% of patients, respectively, at the last follow-up visit (P < 0.001). Mean QoL score increased slightly in the first year and remained stable.ConclusionLong-term persistence with PCSK9i in FH patients is very high, with a good QoL. Effectiveness in LDL-C reduction and LDL-C goal achievement dramatically improved with PCSK9i in this high-risk population in clinical practice setting.Trial registrationClinicalTrials.gov number NCT02693548.

Published
2022

16. Coronary microvascular dysfunction is associated with impaired cognitive function: the Cerebral-Coronary Connection study (C3 study)

Author

Hernan Mejia-Renteria, Alejandro Travieso, Jordi A Matías-Guiu, Miguel Yus, Carolina Espejo-Paeres, Francesca Finocchiaro, Sara Fernández, Carlos Ignacio Gomez-Escalonilla, Blanca Reneses-Prieto, Maria Dulcenombre Gómez-Garré, Alfonso Delgado-Alvarez, Ana Bustos, Leopoldo Perez de Isla, Jose Juan Gomez de Diego, Javier Modrego-Martin, Adriana Ortega-Hernandez, Petros Papadopoulos, Juan Arrazola-García, Jorge Matías-Guiu, and Javier Escaned

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background It remains unknown whether the presence of coronary microcirculatory dysfunction (CMD) correlates with its equivalent condition in the brain, cerebral small vessel disease (CSVD). The cerebral-coronary connection (C3), a prospective blinded study, investigated the prevalence of CMD in patients with coronary artery disease (CAD) and its association with CSVD and cognitive function. Methods and results Patients with documented CAD fulfilling inclusion criteria underwent physiological assessment of epicardial vessels and the microcirculation using intracoronary pressure and Doppler. Coronary microcirculation-related indices included coronary flow reserve (CFR) and hyperaemic microvascular resistance. Brain magnetic resonance imaging, transcranial Doppler (TCD), and neurocognitive examination were performed. Overall, 67 patients were included in the study (mean age 66 years, 73% female). Patients with abnormal CFR ( Conclusions Coronary microcirculatory dysfunction is frequent in patients with CAD and correlates with CSVD, abnormal cerebral flow haemodynamics, and significant cognitive impairment. These findings support the hypothesis that microvascular dysfunction in the heart and the brain are part of a single pathological process affecting microcirculation in patients with CAD. Clinical Trial Registration ClinicalTrials.gov NCT04131075.

Published
2022

18. Comparison of 1-Year Outcome in Patients With Severe Aorta Stenosis Treated Conservatively or by Aortic Valve Replacement or by Percutaneous Transcatheter Aortic Valve Implantation (Data from a Multicenter Spanish Registry)

Author

Saldivar, Hugo González, Rodriguez-Pascual, Carlos, Parajes-Vazquez, Teresa, Montero-Magan, Marina, De la Morena, Gonzalo, Flores-Blanco, Pedro J., Fernández-Golfín, Covadonga, Lozano, Cristina, Rincón, Luis Miguel, Amorós, Carmen, Borras, Xavier, Alonso, Mario Baquero, Camacho, Eva García, Pérez, Andrés Sánchez, Dolz, Luis Martínez, Climent, Herminio Morillas, Sánchez, Jorge Sanz, Vallverdú, María Ferré, Solé, Albert Ariza, Guzmán-Martínez, Gabriela, González-Fernández, Óscar, Gómez-Doblas, Juan José, Jiménez, Antonio Arribas, Garcia Sánchez, Maria Jesús, Sánchez Fernandez, Pedro Luis, Fuentes, María Eugenia, Millán, María Victoria, Gay, Laura Galian, Ortiz, Martin Ruiz, Avanzas, Pablo, Pascual, Isaac, Morís, César, Abu-Assi, Emad, Vera, Tomás Ripoll, Pérez, Yolanda Gómez, Diaz-Castro, Oscar, Borreguero, Jesús Jimenez, Pozo, Eduardo, Antuña, Paula, Viliani, Dafne, Mogollón Jiménez, María Victoria, Gómez, Gonzalo Marcos, García, Marcelino Cortés, Orejas, Miguel Orejas, Quiles, Juan, Gunturiz, Clara, Castrodeza, Javier, Tobar, Javier, López, Javier, Garcia Gonzalez, Martin Jesús, Labrador, Eva Bernal, Ayerbe, Jorge López, Barros, Sonia María, Ruiz, Antoni Carol, Botas, Javier, García, Alberto Núñez, Girgas, Esther Sanz, Ruiz, Alfredo Bardají, Caro Martinez, Cesar S., Aguera, Alicia Gómez, Sierra, Teresa Pareja, Yarcuri, Fiorella Quinte, Rodriguez, Irene Mateo, Martínez, Maria del Pilar Zuazola, Pérez, Teresa, Arrarte Esteban, Vicente Ignacio, Garri, Francisco Sogorb, Ramirez-Marrero, Miguel A., Campaña, Sonia Ibars, Marchan, Ferrán Padilla, Rodríguez-Capitán, Jorge, Andion, Ramón, de Isla, Leopoldo Pérez, Casado, Patricia Mahía, Carrera, José Plaza, de la Villa Redondo, Bernardo García, Valencia-Serrano, Félix M., Bustos, Daniel Bravo, Lacambra-Blasco, Isaac, Isasti, Guillermo, Paves, Alicia Bautista, Pereyra, Eduardo, Pueo, Eva, Santos, Luis Cornide, Martín, Ana Garrido, Lozano, Clara Bonanad, Diaz, Javier Lopez, Calvo, Javier Castrodeza, Ruiz, Javier Tobar, Martínez-Sellés, Manuel, González-Saldivar, Hugo, de la Morena, Gonzalo, Ripoll-Vera, Tomás, Díaz-Castro, Oscar, and Osinalde, Eduardo P.

Published
2016
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21. Subclinical atherosclerosis burden in carotid and femoral territories in HIV subjects: relationships with HIV and non-HIV related factors

Author

Pedro Ferrer, Laura López, Juncal Pérez, Noemi Cabello, María José Núñez, Iñigo Sagastagoitia, Manuel Cotarelo, Leopoldo Pérez de Isla, and Vicente Estrada

Subjects
HIV infection, Subclinical atherosclerosis, Vacular Elastography, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Cardiovascular disease is a major cause of morbidity in an aging HIV population. However, risk estimation with the most frequent equations usually classifies HIV patients as having a low or moderate risk. Several studies have described a very high prevalence of subclinical atherosclerosis in a middle-aged, non-HIV population. There is insufficient body of knowledge to understand if this is the case in people living with HIV (PLWH). We aim to calculate the proportion of patients with subclinical atherosclerosis in a single site cohort of HIV-infected subjects. Methods We have analyzed chronically HIV infected adults (≥ 18 years) who were on active follow-up in an HIV unit specialized in the care of cardiovascular health. The most recent clinical visit and vascular ultrasonography were used to assess the objectives of our research. Our primary objective was to describe the proportion of participants with subclinical atherosclerosis (focal protrusion into the lumen > 0.5 mm or > 50% of the surrounding IMT or a diffuse thickness > 1.5 mm) in a single site cohort of PLWH. Carotid and iliofemoral territories were evaluated. As a secondary objective we have run a multivariate analysis to determine which HIV and non-HIV factors might be related with the presence of atherosclerotic plaques. Findings We included a total of 463 participants between November 2017 to October 2019. Subjects were predominantly male (84.2%) with a mean age of 48.8 years (SD 10.7). Hypercholesterolemia (36%) was the most prevalent comorbidity followed by Hypertension (18%) and Hypertriglyceridemia (16%). Mean duration of HIV infection is 12.3 years. Overall, participants had been receiving cART for a median of 9.5 years. Subclinical atherosclerosis was found in 197 subjects (42.5%; CI 95% [38.0–47.2]). The disease was found more frequently in the femoral arteries (37.8%) than in the carotid vascular bed (18.6%). Despite some HIV factors correlated with the presence of plaques in a univariate analysis (e.g., time with HIV-1 RNA > 50 copies/mL or time from HIV diagnosis), the only two explanatory factors that remained associated with the presence of atherosclerotic plaques in the multivariate analysis were smoking (OR 5.47, 95% CI 3.36 – 8.90) and age (OR 1.13, 95%CI 1.10 – 1.16). Interpretation We have found a very high prevalence of subclinical atherosclerosis among our cohort of PLWH. Despite having analyzed several HIV factors, age and smoking have been found to be the only factors associated with the development of atherosclerotic plaques.

Published
2024
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22. The Added Value of Coronary Calcium Score in Predicting Cardiovascular Events in Familial Hypercholesterolemia

Author

Antonio Gallo, Leopoldo Pérez de Isla, Sybil Charrière, Alexandre Vimont, Rodrigo Alonso, Ovidio Muñiz-Grijalvo, José L. Díaz-Díaz, Daniel Zambón, Philippe Moulin, Eric Bruckert, Pedro Mata, Sophie Béliard, Denis Angoulvant, Sophie Beliard, Franck Boccara, Bertrand Cariou, Valérie Carreau, Alain Carrie, Sybil Charrieres, Yves Cottin, Mathilde Di Filippo, Pierre Henri Ducluzeau, Sonia Dulong, Vincent Durlach, Michel Farnier, Emile Ferrari, Dorota Ferrieres, Jean Ferrieres, Philippe Giral, Sophie Gonbert, Regis Hankard, Jocelyn Inamo, Olga Kalmykova, Michel Krempf, Julie Lemale, François Paillard, Noel Peretti, Agnes Perrin, Alain Pradignac, Jean Pierre Rabes, Vincent Rigalleau, François Schiele, Ariane Sultan, Patrick Tounian, René Valero, Bruno Verges, Cecile Yelnik, Olivier Ziegler, Rocío Aguado, Ma Pilar Álvarez-Baños, Rosa Argüeso, Francisco Arrieta, Miguel Ángel Barba, Marta Casañas, José María Cepeda, Raimundo De Andrés, Gonzalo Díaz-Soto, Jose Luis Díaz-Diaz, Marta Dieguez, Ceferino Faedo, Francisco Fuentes, Juan A. Garrido, Aurora González, Pablo González-Bustos, Ma Dolores Mañas, Marta Mauri, Juan Diego Mediavilla, Alfredo Michán, Pablo Miramontes, Ovidio Muñiz, Leire Pérez, Leopoldo Perez De Isla, Xavier Pintó, Manuel J. Romero, Patricia Rubio, Juan F. Sánchez Muñoz-Torrero, Jose I. Vidal-Pardo, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] (IdISSC), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Public Health Expertise [Paris, France], Hospital Universitario Virgen del Rocío [Sevilla], Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire d'Imagerie Biomédicale [Paris] (LIB), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Hospital Abente y Lago, Fundación Hipercolesterolemia Familiar, and ANR-16-RHUS-0007,CHOPIN,CHOPIN(2016)

Subjects
Adult, Male, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Coronary Artery Disease, Disease, Familial hypercholesterolemia, 030204 cardiovascular system & hematology, Risk Assessment, Sudden death, Cohort Studies, Hyperlipoproteinemia Type II, risk prediction, 03 medical and health sciences, 0302 clinical medicine, cardiovascular disease, genetic disease, Predictive Value of Tests, Risk Factors, Interquartile range, Internal medicine, Humans, Medicine, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Vascular Calcification, Stroke, coronary artery calcium, ComputingMilieux_MISCELLANEOUS, familial hypercholesterolemia, business.industry, Proportional hazards model, nutritional and metabolic diseases, Middle Aged, Atherosclerosis, medicine.disease, 3. Good health, Coronary Calcium Score, Cardiology, Calcium, Cardiology and Cardiovascular Medicine, business, coronary imaging, Cohort study
Abstract

International audience; ObjectivesThis study aimed at investigating the additional contribution of coronary artery calcium (CAC) score to SAFEHEART (Spanish Familial Hypercholesterolemia Cohort Study) risk equation (SAFEHEART-RE) for cardiovascular risk prediction in heterozygous familial hypercholesterolemia (HeFH).BackgroundCommon cardiovascular risk equations are imprecise for HeFH. Because of the high phenotype variability of HeFH, CAC score could help to better stratify the risk of atherosclerotic cardiovascular disease (ASCVD).MethodsREFERCHOL (French Registry of Familial Hypercholesterolemia) and SAFEHEART are 2 ongoing national registries on HeFH. We analyzed data from primary prevention HeFH patients undergoing CAC quantification. We used probability-weighted Cox proportional hazards models to estimate HRs. Area under the receiver-operating characteristic curve (AUC) and net reclassification improvement (NRI) were used to compare the incremental contribution of CAC score when added to the SAFEHEART-RE for ASCVD prediction. ASCVD was defined as coronary heart disease, stroke or transient ischemic attack, peripheral artery disease, resuscitated sudden death, and cardiovascular death.ResultsWe included 1,624 patients (mean age: 48.5 ± 12.8 years; men: 45.7%) from both registries. After a median follow-up of 2.7 years (interquartile range: 0.4-5.0 years), ASCVD occurred in 81 subjects. The presence of a CAC score of >100 was associated with an HR of 32.05 (95% CI: 10.08-101.94) of developing ASCVD as compared to a CAC score of 0. Receiving-operating curve analysis showed a good performance of CAC score alone in ASCVD prediction (AUC: 0.860 [95% CI: 0.853-0.869]). The addition of log(CAC + 1) to SAFEHEART-RE resulted in a significantly improved prediction of ASCVD (AUC: 0.884 [95% CI: 0.871-0.894] for SAFEHEART-RE + log(CAC + 1) vs AUC: 0.793 [95% CI: 0.779-0.818] for SAFEHEART-RE; P < 0.001). These results were confirmed also when considering only hard cardiovascular endpoints. The addition of CAC score was associated with an estimated overall net reclassification improvement of 45.4%.ConclusionsCAC score proved its use in improving cardiovascular risk stratification and ASCVD prediction in statin-treated HeFH.

Published
2021

25. Persistence with long-term PCSK9 inhibitor treatment and its effectiveness in familial hypercholesterolaemia: data from the SAFEHEART study

Author

Alonso, Rodrigo, primary, Arroyo-Olivares, Raquel, additional, Muñiz-Grijalvo, Ovidio, additional, Díaz-Díaz, Jose Luis, additional, Muñoz-Torrero, Juan Sanchez, additional, Romero, Manuel J, additional, de Andrés, Raimundo, additional, Zambón, Daniel, additional, Mañas, María Dolores, additional, Fuentes-Jiménez, Francisco, additional, Aguado, Rocío, additional, Alvarez-Baños, Pilar, additional, Arrieta, Francisco, additional, Gonzalez-Bustos, Pablo, additional, Cepeda, José, additional, Martin-Ordiales, Mercedes, additional, Mosquera, Daniel, additional, Michan, Alfredo, additional, de Isla, Leopoldo Perez, additional, Argueso, Rosa, additional, and Mata, Pedro, additional

Published
2022
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31. Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study

Author

David Adams, Michael Polydefkis, Alejandra González-Duarte, Jonas Wixner, Arnt V Kristen, Hartmut H Schmidt, John L Berk, Inés Asunción Losada López, Angela Dispenzieri, Dianna Quan, Isabel M Conceição, Michel S Slama, Julian D Gillmore, Theodoros Kyriakides, Senda Ajroud-Driss, Márcia Waddington-Cruz, Michelle M Mezei, Violaine Planté-Bordeneuve, Shahram Attarian, Elizabeth Mauricio, Thomas H Brannagan, Mitsuharu Ueda, Emre Aldinc, Jing Jing Wang, Matthew T White, John Vest, Erhan Berber, Marianne T Sweetser, Teresa Coelho, Giuseppe Vita, Vincenzo Rizzo, Massimo Russo, Anna Mazzeo, Luca Gentile, Caitlin Brueckner, Victoria Lazzari, Janice Wiesman, Douglas DeLong, Jennifer Victory, James Dalton, John May, Catherine Gilmore, Saran Diallo, Emilien Delmont, Jean Pouget, Annie Verschueren, Aude-Marie Grapperon, Emmanuelle Campana-Salort, Ana Lopes, Filipa Lamas, Carlos Neves, Jose Castro, Pedro Pereira, Isabel Castro, Ana Franco, Miguel Oliveira Santos, Conceição de Azevedo Coutinho, Catarina Falcao de Campos, Antonio Hipólito Reis, Nuno Correia, Javier M Perez, Ana Martins da Silva, Cristina Alves, Marcio Cardoso, Katia Valdrez, Julia R Monte, Bernardete Pessoa, Nadia Guimaraes, Monica Freitas, Joana Ramalho, Natalia Ferreira, Daisuke Kuzume, Celine Tard, Nawal Waucquier, Isabelle Rougeaux, Sylvie Brice, Emmanuelle Kasprzyk, Elise Elrezzi, Sayah Meguig, Eric Hachulla, Clement Gauvain, Maria-Claire Migaud-Chervy, Dominique Deplanque, Elsa Jozefowicz, Loic Lebellec, Line Balaya-Gouraya, Nathalie Jehan Lacour, Halima Bournane, Nathalie Martin, Mongia Elabed, Niamey Sacko, Yasmine Boubrit, Amina Gaouar, Fetra Rakotondratafika, Marie Théaudin-Saliou, Cécile Cauquil-Michon, Celine Labeyrie, Adeline Not, Abdallah Al-Salameh, Anne-Lise Lecoq, Maeva Stephant, Andoni Echaniz-Laguna, Laurent Becquemont, Guillemette Beaudonnet, Vincent Algalarrondo, Ludivine Eliahou, Antoine Rousseau, Aissatou Signate, Emeline Berthelot, Jocelyn Inamo, Laetitia Vervoitte, Cecile Focseneanu, Thierry Gendre, Raphaele Arrouasse, Samar S. Ayache, Laura Ernande, Philippe Le Corvoisier, Hayet Salhi, Ariane Choumert, Vincent Ehinger, Julie Ruiz, Cyril Charlin, Thomas Megelin, Thomas H Brannagan III, Raisy Fayerman, Arreum Kim, Allan Paras, Leidy J Gonzalez, Steven Tsang, Fernanda Wajnsztajn, Jeffrey Shije, Christina Ulane, Inna Kleyman, Louis Weimer, Comana Cioroiu, Sakis Lambrianides, Rana Abu-Manneh, Eleni Zamba-Papanicolaou, Petros Agathangelou, Eleni Leonidou, Satoshi Tada, Akemi Fujita, Masahiro Nagai, Rina Ando, Yuko Hosokawa, Yuki Yamanishi, J. Scott Overcash, Elena Giardino, Leslie Boyer, Lien Dang, An Le, Tyler Nguyen, Lien Giang, Peter Sellers, Leyla Tran, Nghi Truong, Maita Vinas, Nicole Hrkman, Sarah Miller, David Nguyen, Ashley Smith, Helen Pu, Steve Li, Thao Vuong, Holly Dioso, Sinikka Green, Kia Lee, Hanh Chu, Michael Waters, Derya J Coskun, Karla A Zepeda, William O'Riordan, Laura Obici, Andrea Cortese, Alessandro Lozza, Giampaolo Merlini, Vittorio Rosti, Mario Sabatelli, Giulia Bisogni, Daniela Bernardo, Marco Luigetti, Andrea Di Paolantonio, Valeria Guglielmino, Angela Romano, Hans Nienhuis, Janita Bulthuis-Kuiper, Olga Gerk, Hannah Ulbricht, Lenka Taylor, Eva Meyle, Natalia Kleinschmidt, David Meyrath, Simone Noe-Schwenn, Ulrike Meng, Ralf Bauer, Fabian aus dem Siepen, Selina Hein, Tetsuya Takahashi, Tomohiko Oshita, Yoko Koujin, Shuichiro Neshige, Tomohisa Nezu, Akiko Segawa, Hiroki Ueno, Hiroyuki Morino, Josep M Campistol, Lida Maria Rodas Marin, Josep Miquel Blasco Pelicano, Lucía Galán Dávila, Marta Palacios, Vanesa Pytel Cordoba, Antonio Guerrero Sola, Alejandro Horga, Julián García Feijoo, Leopoldo Perez de Isla, Wilson Marques Júnior, Mariana Moscardini, Debora Cristina Litcanov, Ana Flavia Viera Lima, Leonardo Rodrigues, Barbara Marques Coutinho, Carolina Lavigne Moreira, Vanessa Daccach Marques, Francisco Munoz Beamud, Álvaro Gragera Martínez, Cristina Borrachero, Eugenia Cisneros Barroso, Adrián Rodríguez Rodríguez, Monica Sanz, Elena Rigo Oliver, Juan González Moreno, Jose M Gamez Martinez, Cristina Descals, Mercedes Uson, Francisco Jose Vega, Antoni Figuerola, Carles Montala, Moises Dias da Silva, Renata Gervais de Santa Rosa, Luiz Felipe Pinto, Marcus Vinicius Pinto, Amanda Cardoso Berensztejn, Fabio Barroso, Andrea Lautre, Lucas G Orellana, Maria Alejandra González-Duarte Briseño, Karla Cárdenas-Soto, Brenda Poled Jiménez López, Sandra Lorena Pérez-Castañeda, Carlos Gerardo Cantú Brito, David Rivera de la Parra, Jose Pablo Hernandez Reyes, Maria del Mar Saniger Alba, Elia Criollo Mora, Yesim Parman, Kus Jülide Rezzan, Erdi Sahin, Nail G Serbest, Hacer Durmus, Arman Cakar, Nuriye Ilknur Tugal Tutkun, Sacit Karamursel, Ali Elitok, Nermin G Sirin Inan, Emre Altinkurt, Jing Ye, Adriane C Allen, Vinay Chaudhry, Raquel Jarrett, Neil Bressler, Kathleen L Burks, Qingfeng Liu, Mohammad Khoshnoodi, Daniel P Judge, Geno Vista, Syed Mahmood Shah, Hirotoshi Hamaguchi, Junko Oda, Emi Fukase, Ikuko Taniguchi, Tetsuya Oda, Hironobu Endo, Masahiro Shimomura, Kimitaka Katanazaka, Shusuke Koto, Takahiro Nakano, Christof Scheid, Andreas Zueiter, Lars Pester, Doreen Walter, Betül Özdemir, Lukas F Frenzel, Udo Holtick, Jeeyoung Oh, Hee Jin Kim, Hyun Jin Shin, Kyomin Choi, Taro Yamashita, Teruaki Masuda, Yohei Misumi, Akihiko Ueda, Keiichi Nakahara, Akiko Yorita, Seiko Tsuruhisa, Takayuki Taniwaki, Masaya Harada, Taiga Moritaka, Naonori Sakurada, Elizabeth A Mauricio, Amber Baskin, Elliot Dimberg, Amie Fonder, Miriam Hobbs, Stephen J Russell, Peter Dyck, Wilson Gonsalves, Nelson Leung, Thomas E Witzig, Steven R Zeldenrust, Lisa Hwa, Prashant Kapoor, Shaji K Kumar, Yi Lin, John A Lust, Vincent S Rajkumar, David Dingli, Morie A Gertz, Ronald Go, Suzanne R Hayman, Samir Dalia, Esmeralda Carrillo, Peter Gorevic, Garnette Mason, Chi-Chao Chao, Ming-Jen Lee, Jen-Jen Su, Sung-Tsang Hsieh, Li-Kai Tsai, Shin-Joe Yeh, Chih-Chao Yang, Senda Ajroud-Driss Ajroud-Driss, Patricia Casey, Benjamin C Joslin, Miriam Freimer, Alison Sankey, Amanda Kenepp, Sarah Heintzman, Samantha LoRusso, Youichi Hokezu, Byoung-Joon Kim, JuHyeon Kim, Ga Yeon Lee, Eun Bin Cho, Eun-Seok Jeon, Ju-Hong Min, Jin Myoung Seok, Hye Lim Lee, Jae Hong Park, Yoshiki Sekijima, Chinatsu Miyazawa, Nagaaki Kato, Dai Kishida, Akiyo Hineno, Minori Kodaira, Tsuneaki Yoshinaga, Teruyoshi Miyahara, Akira Imai, Kazuhiko Matsumoto, Kon-Ping Lin, Yi-Chung Lee, Malin Falk, Bjorn Pilebro, Ole Suhr, Per Lindqvist, Karin Soderberg, Fatima Pedrosa-Domellöf, Intissar Anan, Erik Nordh, Ivaylo Tournev, Sashka Zhelyazkova-Glaveeva, Zheyna Cherneva, Staiko Sarafov, Teodora Chamova, Sylvia Cherninkova-Gopina, Frauke Friebel, Andree Zibert, Natasa Mihailovic, Friederike Schubert, Elena Vorona, Larissa Lahme, Anna Huesing-Kabar, Matthias Schilling, Iyad Kabar, Ana Martinez-Naharro, Liza Chacko, Oliver Cohen, Steven Law, Tamer Rezk, Helen J Lachmann, Brianna Blume, Stacy Dixon, Soon Chai Low, Soo Looi Chan, He Eng Li Lim, Khean Jin Goh, Deborah Kraus, Kristin Jack, N. Kevin Wade, Glenn Lopate, Brittany Zwijack, Julaine Florence, R. Brian Sommerville, Graeme Stewart, Julie Ryder, Linda Mekhael, Mark Taylor, Daniel Suan, Karen Wells, Paula Stone, Amenze Itoya, Mercy Owusu-Sekyere, Desmond Thai, Ilonah Chahine, Salve Pedrosa, Thi Hoa (Therese) Do, and Repositório da Universidade de Lisboa

Subjects
Adult, Male, medicine.medical_specialty, Drug-Related Side Effects and Adverse Reactions, 030204 cardiovascular system & hematology, Placebo, Severity of Illness Index, Polyneuropathies, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Internal medicine, Outcome Assessment, Health Care, Severity of illness, medicine, Humans, Prealbumin, RNA, Small Interfering, Infusions, Intravenous, Adverse effect, Aged, Amyloid Neuropathies, Familial, business.industry, Middle Aged, medicine.disease, Interim analysis, amyloidosis, transthyretin, polyneuropathy, patisiran, OLE study, Clinical trial, Female, Neurology (clinical), business, Polyneuropathy, 030217 neurology & neurosurgery, Progressive disease
Abstract

© 2020 Elsevier Ltd. All rights reserved., Background: Hereditary transthyretin-mediated amyloidosis is a rare, inherited, progressive disease caused by mutations in the transthyretin (TTR) gene. We assessed the safety and efficacy of long-term treatment with patisiran, an RNA interference therapeutic that inhibits TTR production, in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy. Methods: This multicentre, open-label extension (OLE) trial enrolled patients at 43 hospitals or clinical centres in 19 countries as of Sept 24, 2018. Patients were eligible if they had completed the phase 3 APOLLO or phase 2 OLE parent studies and tolerated the study drug. Eligible patients from APOLLO (patisiran and placebo groups) and the phase 2 OLE (patisiran group) studies enrolled in this global OLE trial and received patisiran 0·3 mg/kg by intravenous infusion every 3 weeks with plans to continue to do so for up to 5 years. Efficacy assessments included measures of polyneuropathy (modified Neuropathy Impairment Score +7 [mNIS+7]), quality of life, autonomic symptoms, nutritional status, disability, ambulation status, motor function, and cardiac stress, with analysis by study groups (APOLLO-placebo, APOLLO-patisiran, phase 2 OLE patisiran) based on allocation in the parent trial. The global OLE is ongoing with no new enrolment, and current findings are based on the interim analysis of the patients who had completed 12-month efficacy assessments as of the data cutoff. Safety analyses included all patients who received one or more dose of patisiran up to the data cutoff. This study is registered with ClinicalTrials.gov, NCT02510261. Findings: Between July 13, 2015, and Aug 21, 2017, of 212 eligible patients, 211 were enrolled: 137 patients from the APOLLO-patisiran group, 49 from the APOLLO-placebo group, and 25 from the phase 2 OLE patisiran group. At the data cutoff on Sept 24, 2018, 126 (92%) of 137 patients from the APOLLO-patisiran group, 38 (78%) of 49 from the APOLLO-placebo group, and 25 (100%) of 25 from the phase 2 OLE patisiran group had completed 12-month assessments. At 12 months, improvements in mNIS+7 with patisiran were sustained from parent study baseline with treatment in the global OLE (APOLLO-patisiran mean change -4·0, 95 % CI -7·7 to -0·3; phase 2 OLE patisiran -4·7, -11·9 to 2·4). Mean mNIS+7 score improved from global OLE enrolment in the APOLLO-placebo group (mean change from global OLE enrolment -1·4, 95% CI -6·2 to 3·5). Overall, 204 (97%) of 211 patients reported adverse events, 82 (39%) reported serious adverse events, and there were 23 (11%) deaths. Serious adverse events were more frequent in the APOLLO-placebo group (28 [57%] of 49) than in the APOLLO-patisiran (48 [35%] of 137) or phase 2 OLE patisiran (six [24%] of 25) groups. The most common treatment-related adverse event was mild or moderate infusion-related reactions. The frequency of deaths in the global OLE was higher in the APOLLO-placebo group (13 [27%] of 49), who had a higher disease burden than the APOLLO-patisiran (ten [7%] of 137) and phase 2 OLE patisiran (0 of 25) groups. Interpretation: In this interim 12-month analysis of the ongoing global OLE study, patisiran appeared to maintain efficacy with an acceptable safety profile in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy. Continued long-term follow-up will be important for the overall assessment of safety and efficacy with patisiran.

Published
2021

32. Persistence with long-term PCSK9 inhibitor treatment and its effectiveness in familial hypercholesterolaemia: data from the SAFEHEART study.

Author

Alonso, Rodrigo, Arroyo-Olivares, Raquel, Muñiz-Grijalvo, Ovidio, Díaz-Díaz, Jose Luis, Muñoz-Torrero, Juan Sanchez, Romero, Manuel J, Andrés, Raimundo de, Zambón, Daniel, Mañas, María Dolores, Fuentes-Jiménez, Francisco, Aguado, Rocío, Alvarez-Baños, Pilar, Arrieta, Francisco, Gonzalez-Bustos, Pablo, Cepeda, José, Martin-Ordiales, Mercedes, Mosquera, Daniel, Michan, Alfredo, Isla, Leopoldo Perez de, and Argueso, Rosa

Published
2023
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34. New insights of tricuspid regurgitation: a large-scale prospective cohort study

Author

J M Monteagudo, Irene Marco, Teresa Gonzalez, P Mahia, David Alonso, Marta Sitges, Leopoldo Perez, José Luis Zamorano, Francesco Perone, Pedro Li, Violeta González, Covadonga Fernández-Golfín, Teresa María Ortega López, José María de la Heras, Fernando Carrasco, Jose Maria Vieitez, Antonio Adeba, and Alberto Bouzas

Subjects
medicine.medical_specialty, Percutaneous, Systolic hypertension, 030204 cardiovascular system & hematology, Severity of Illness Index, Ventricular Function, Left, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Tricuspid Valve Insufficiency, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Retrospective Studies, Heart Valve Prosthesis Implantation, Ejection fraction, Tricuspid valve, business.industry, Aortic valve disorder, Stroke Volume, General Medicine, medicine.disease, Treatment Outcome, medicine.anatomical_structure, Ventricle, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract

Aims To evaluate the burden of tricuspid regurgitation (TR) in a large cohort, determine the right ventricle involvement of patients with TR and determine the characteristics of isolated TR. Methods and results Prospective study where consecutive patients undergoing an echocardiographic study in 10 centres were included. All studies with significant TR (at least moderate) were selected. We considered that patients with one of pulmonary systolic hypertension >50 mmHg, left ventricular ejection fraction Conclusion Significant TR is a prevalent condition and a high proportion of these patients have an indication for valve intervention. More than a half of patients with severe, massive, or torrential TR had a high surgical risk. Massive/torrential TR may have implications regarding selection and monitoring patients for percutaneous treatment.

Published
2020

38. The Added Value of Coronary Calcium Score in Predicting Cardiovascular Events in Familial Hypercholesterolemia

Author

Gallo, Antonio, primary, Pérez de Isla, Leopoldo, additional, Charrière, Sybil, additional, Vimont, Alexandre, additional, Alonso, Rodrigo, additional, Muñiz-Grijalvo, Ovidio, additional, Díaz-Díaz, José L., additional, Zambón, Daniel, additional, Moulin, Philippe, additional, Bruckert, Eric, additional, Mata, Pedro, additional, Béliard, Sophie, additional, Angoulvant, Denis, additional, Beliard, Sophie, additional, Boccara, Franck, additional, Cariou, Bertrand, additional, Carreau, Valérie, additional, Carrie, Alain, additional, Charrieres, Sybil, additional, Cottin, Yves, additional, Di Filippo, Mathilde, additional, Ducluzeau, Pierre Henri, additional, Dulong, Sonia, additional, Durlach, Vincent, additional, Farnier, Michel, additional, Ferrari, Emile, additional, Ferrieres, Dorota, additional, Ferrieres, Jean, additional, Gallo, Antonio, additional, Giral, Philippe, additional, Gonbert, Sophie, additional, Hankard, Regis, additional, Inamo, Jocelyn, additional, Kalmykova, Olga, additional, Krempf, Michel, additional, Lemale, Julie, additional, Paillard, François, additional, Peretti, Noel, additional, Perrin, Agnes, additional, Pradignac, Alain, additional, Rabes, Jean Pierre, additional, Rigalleau, Vincent, additional, Schiele, François, additional, Sultan, Ariane, additional, Tounian, Patrick, additional, Valero, René, additional, Verges, Bruno, additional, Yelnik, Cecile, additional, Ziegler, Olivier, additional, Aguado, Rocío, additional, Álvarez-Baños, Ma Pilar, additional, Argüeso, Rosa, additional, Arrieta, Francisco, additional, Barba, Miguel Ángel, additional, Casañas, Marta, additional, Cepeda, José María, additional, De Andrés, Raimundo, additional, Díaz-Soto, Gonzalo, additional, Díaz-Diaz, Jose Luis, additional, Dieguez, Marta, additional, Faedo, Ceferino, additional, Fuentes, Francisco, additional, Garrido, Juan A., additional, González, Aurora, additional, González-Bustos, Pablo, additional, Mañas, Ma Dolores, additional, Mauri, Marta, additional, Mediavilla, Juan Diego, additional, Michán, Alfredo, additional, Miramontes, Pablo, additional, Muñiz, Ovidio, additional, Pérez, Leire, additional, De Isla, Leopoldo Perez, additional, Pintó, Xavier, additional, Romero, Manuel J., additional, Rubio, Patricia, additional, Sánchez Muñoz-Torrero, Juan F., additional, and Vidal-Pardo, Jose I., additional

Published
2021
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39. Coronary microvascular dysfunction is associated with impaired cognitive function: the Cerebral-Coronary Connection study (C3 study).

Author

Mejia-Renteria, Hernan, Travieso, Alejandro, Matías-Guiu, Jordi A, Yus, Miguel, Espejo-Paeres, Carolina, Finocchiaro, Francesca, Fernández, Sara, Gomez-Escalonilla, Carlos Ignacio, Reneses-Prieto, Blanca, Gómez-Garré, Maria Dulcenombre, Delgado-Alvarez, Alfonso, Bustos, Ana, Isla, Leopoldo Perez de, Diego, Jose Juan Gomez de, Modrego-Martin, Javier, Ortega-Hernandez, Adriana, Papadopoulos, Petros, Arrazola-García, Juan, Matías-Guiu, Jorge, and Escaned, Javier

Subjects
MICROCIRCULATION disorders, CEREBRAL small vessel diseases, MINI-Mental State Examination, COGNITIVE ability, TRAIL Making Test, MAGNETIC resonance imaging
Abstract

Background It remains unknown whether the presence of coronary microcirculatory dysfunction (CMD) correlates with its equivalent condition in the brain, cerebral small vessel disease (CSVD). The cerebral-coronary connection (C3), a prospective blinded study, investigated the prevalence of CMD in patients with coronary artery disease (CAD) and its association with CSVD and cognitive function. Methods and results Patients with documented CAD fulfilling inclusion criteria underwent physiological assessment of epicardial vessels and the microcirculation using intracoronary pressure and Doppler. Coronary microcirculation-related indices included coronary flow reserve (CFR) and hyperaemic microvascular resistance. Brain magnetic resonance imaging, transcranial Doppler (TCD), and neurocognitive examination were performed. Overall, 67 patients were included in the study (mean age 66 years, 73% female). Patients with abnormal CFR (<2.0) (55.2%) showed higher burden of white-matter hyperintensities: 43.2 vs. 20.0% (P = 0.044). After statistical adjustment, low CFR was associated with lower grey matter volume (P = 0.024) and with parameters of white-matter microstructural damage in diffusion-tensor imaging (lower fractional anisotropy and higher mean diffusivity, P = 0.029 and P = 0.032, respectively). Low CFR was associated with higher resistive (P = 0.027) and pulsatility (P = 0.043) values on TCD, and worse neurocognitive test scores (lower mini mental state examination, P = 0.025, and slower Trail Making Test A, P = 0.034). Conclusions Coronary microcirculatory dysfunction is frequent in patients with CAD and correlates with CSVD, abnormal cerebral flow haemodynamics, and significant cognitive impairment. These findings support the hypothesis that microvascular dysfunction in the heart and the brain are part of a single pathological process affecting microcirculation in patients with CAD. Clinical Trial Registration ClinicalTrials.gov NCT04131075. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Estudio de la deformación miocárdica: predictor de disfunción ventricular a medio plazo tras cirugía en pacientes con insuficiencia mitral crónica

Author

de Agustín, José A., de Isla, Leopoldo Pérez, Núñez-Gil, Iván J., Vivas, David, Manzano, María del C., Marcos-Alberca, Pedro, Fernández-Golfín, Covadonga, Corros, Cecilia, Almería, Carlos, Rodrigo, José L., Aubele, Adalia, Herrera, Dionisio, Rodríguez, Enrique, Macaya, Carlos, and Zamorano, José

Published
2010
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44. Assessment of Myocardial Deformation: Predicting Medium-term left Ventricular Dysfunction after Surgery in Patients With chronic Mitral regurgitation

Author

de Agustín, José A., de Isla, Leopoldo Pérez, Núñez-Gil, Iván J., Vivas, David, Manzano, María del C., Marcos-Alberca, Pedro, Fernández-Golfín, Covadonga, Corros, Cecilia, Almería, Carlos, Rodrigo, José L., Aubele, Adalia, Herrera, Dionisio, Rodríguez, Enrique, Macaya, Carlos, and Zamorano, José

Published
2010
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47. Corrigendum to '2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk' [Atherosclerosis 290 (2019) 140–205]

Author

Francois Mach, Colin Baigent, Alberico L. Catapano, Konstantinos C. Koskinas, Manuela Casula, Lina Badimon, M. John Chapman, Guy G. De Backer, Victoria Delgado, Brian A. Ference, Ian M. Graham, Alison Halliday, Ulf Landmesser, Borislava Mihaylova, Terje R. Pedersen, Gabriele Riccardi, Dimitrios J. Richter, Marc S. Sabatine, Marja-Riitta Taskinen, Lale Tokgozoglu, Olov Wiklund, Djamaleddine Nibouche, Parounak H. Zelveian, Peter Siostrzonek, Ruslan Najafov, Philippe van de Borne, Belma Pojskic, Arman Postadzhiyan, Lambros Kypris, Jindřich Špinar, Mogens Lytken Larsen, Hesham Salah Eldin, Margus Viigimaa, Timo E. Strandberg, Jean Ferrieres, Rusudan Agladze, Ulrich Laufs, Loukianos Rallidis, Laszlo Bajnok, Thorbjorn Gudjonsson, Vincent Maher, Yaakov Henkin, Michele Massimo Gulizia, Aisulu Mussagaliyeva, Gani Bajraktari, Alina Kerimkulova, Gustavs Latkovskis, Omar Hamoui, Rimvydas Slapikas, Laurent Visser, Philip Dingli, Victoria Ivanov, Aneta Boskovic, Mbarek Nazzi, Frank Visseren, Irena Mitevska, Kjetil Retterstol, Piotr Jankowski, Ricardo Fontes-Carvalho, Dan Gaita, Marat Ezhov, Marina Foscoli, Vojislav Giga, Daniel Pella, Zlatko Fras, Leopoldo Perez de Isla, Emil Hagstrom, Roger Lehmann, Leila Abid, Oner Ozdogan, Olena Mitchenko, Riyaz S. Patel, Stephan Windecker, Victor Aboyans, Jean-Philippe Collet, Veronica Dean, Donna Fitzsimons, Chris P. Gale, Diederick Grobbee, Sigrun Halvorsen, Gerhard Hindricks, Bernard Iung, Peter Juni, Hugo A. Katus, Christophe Leclercq, Maddalena Lettino, Basil S. Lewis, Bela Merkely, Christian Mueller, Steffen Petersen, Anna Sonia Petronio, Marco Roffi, Evgeny Shlyakhto, Iain A. Simpson, Miguel Sousa-Uva, and Rhian M. Touyz

Subjects
Cardiology and Cardiovascular Medicine
Published
2020

48. Erratum to '2019 ESC/EAS guidelines for the management of dyslipidemias: Lipid modification to reduce cardiovascular risk' [Atherosclerosis 290 (2019) 140–205]

Author

Francois Mach, Colin Baigent, Alberico L. Catapano, Konstantinos C. Koskinas, Manuela Casula, Lina Badimon, M. John Chapman, Guy G. De Backer, Victoria Delgado, Brian A. Ference, Ian M. Graham, Alison Halliday, Ulf Landmesser, Borislava Mihaylova, Terje R. Pedersen, Gabriele Riccardi, Dimitrios J. Richter, Marc S. Sabatine, Marja-Riitta Taskinen, Lale Tokgozoglu, Olov Wiklund, Djamaleddine Nibouche, Parounak H. Zelveian, Peter Siostrzonek, Ruslan Najafov, Philippe van de Borne, Belma Pojskic, Arman Postadzhiyan, Lambros Kypris, Jindřich Špinar, Mogens Lytken Larsen, Hesham Salah Eldin, Margus Viigimaa, Timo E. Strandberg, Jean Ferrieres, Rusudan Agladze, Ulrich Laufs, Loukianos Rallidis, Laszlo Bajnok, Thorbjorn Gudjonsson, Vincent Maher, Yaakov Henkin, Michele Massimo Gulizia, Aisulu Mussagaliyeva, Gani Bajraktari, Alina Kerimkulova, Gustavs Latkovskis, Omar Hamoui, Rimvydas Slapikas, Laurent Visser, Philip Dingli, Victoria Ivanov, Aneta Boskovic, Mbarek Nazzi, Frank Visseren, Irena Mitevska, Kjetil Retterstol, Piotr Jankowski, Ricardo Fontes-Carvalho, Dan Gaita, Marat Ezhov, Marina Foscoli, Vojislav Giga, Daniel Pella, Zlatko Fras, Leopoldo Perez de Isla, Emil Hagstrom, Roger Lehmann, Leila Abid, Oner Ozdogan, Olena Mitchenko, Riyaz S. Patel, Stephan Windecker, Victor Aboyans, Jean-Philippe Collet, Veronica Dean, Donna Fitzsimons, Chris P. Gale, Diederick Grobbee, Sigrun Halvorsen, Gerhard Hindricks, Bernard Iung, Peter Juni, Hugo A. Katus, Christophe Leclercq, Maddalena Lettino, Basil S. Lewis, Bela Merkely, Christian Mueller, Steffen Petersen, Anna Sonia Petronio, Marco Roffi, Evgeny Shlyakhto, Iain A. Simpson, Miguel Sousa-Uva, and Rhian M. Touyz

Subjects
03 medical and health sciences, 0302 clinical medicine, business.industry, Medicine, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Lipid modification, Cardiology and Cardiovascular Medicine, Bioinformatics, business
Published
2020

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