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1. The pan - COVID - AGICT study. The impact of COVID-19 pandemic on surgically treated pancreatic cancer patients. A multicentric Italian study

Author

Giuliani, Giuseppe, Guerra, Francesco, Santelli, Francesco, Esposito, Alessandro, De Pastena, Matteo, Cova, Chiara, Bianchi, Beatrice, Nobile, Sara, Maruccio, Martina, Faustini, Federico, Turri, Giulia, Pedrazzani, Corrado, Kauffmann, Emanuele Federico, Boggi, Ugo, Solaini, Leonardo, Ercolani, Giorgio, Mastrangelo, Laura, Jovine, Elio, Di Franco, Gregorio, Morelli, Luca, Mazzola, Michele, Ferrari, Giovanni, Langella, Serena, Ferrero, Alessandro, La Mendola, Roberta, Hilal, Mohamnad Abu, Depalma, Norma, D'Ugo, Stefano, Spampinato, Marcello Giuseppe, Frisini, Marco, Brolese, Alberto, Palaia, Raffaele, Belli, Andrea, Cillara, Nicola, Deserra, Antonello, Cannavera, Alessandro, Sagnotta, Andrea, Mancini, Stefano, Pinotti, Enrico, Montuori, Mauro, Pecora, Irene, Messinese, Simona, Salvischiani, Lucia, Esposito, Sofia, Ferraro, Luca, Rega, Daniela, Delrio, Paolo, La Raja, Carlotta, Spinelli, Antonino, Massaron, Simonetta, De Nardi, Paola, Deidda, Simona, Restivo, Angelo, Marano, Alessandra, Borghi, Felice, Piccoli, Micaela, Cozzani, Federico, Del Rio, Paolo, Marcellinaro, Rosa, Carlini, Massimo, De Rosa, Raffaele, Scabini, Stefano, Maiello, Fabio, Polastri, Roberto, Zese, Monica, Parini, Dario, Casaril, Andrea, Moretto, Gianluigi, De Leo, Antonio, Catarci, Marco, Trapani, Renza, Zonta, Sandro, Marsanic, Patrizia, Muratore, Andrea, Coppola, Alessandro, Caputo, Damiano, Andreuccetti, Jacopo, Pignata, Giusto, Mariani, Lorenzo, Ceccarelli, Graziano, Giuseppe, Rocco, Bolzon, Stefano, Grasso, Mariateresa, Testa, Silvio, Germani, Paola, de Manzini, Nicolò, Coletta, Diego, De Franco, Lorenzo, Benigni, Roberto, Tribuzi, Angela, Marra, Ubaldo, Di Marino, Michele, Zorcolo, Luigi, Lisi, Giorgio, Allisiardi, Fabrizio, Grieco, Michele, Righetti, Carolina, Grassia, Michele, Lucchi, Andrea, Bagaglini, Giulia, Sica, Giuseppe S., Manara, Michele, Turati, Luca, Macone, Lorenzo, Carminati, Roberta, Mariani, Pierpaolo, Rizzo, Gianluca, Coco, Claudio, Pennella, Francesca Pennetti, Rondelli, Fabio, Romano, Lucia, Giuliani, Antonio, Albino, Vittorio, Leongito, Maddalena, David, Giulia, Misitano, Pasquale, Pasulo, Silvia, Baiocchi, Gian Luca, Baldari, Ludovica, Cassinotti, Elisa, Boni, Luigi, Capolupo, Gabriella Teresa, Caricato, Marco, Bombardini, Cristina, Anania, Gabriele, Dibra, Rigers, Martines, Gennaro, Oliva, Renato, Carati, Maria Vittoria, Grazi, Gian Luca, Marchegiani, Francesco, Spolverato, Gaya, Celotto, Francesco, Pucciarelli, Salvatore, La Torre, Filippo, Iannone, Immacolata, Krizzuk, Dimitri, Sammartino, Francesco, Catalano, Giorgia, Strignano, Paolo, Romagnoli, Renato, Piccione, Domenico, Nardo, Bruno, Reddavid, Rossella, Degiuli, Maurizio, Gerosa, Martino, Maggioni, Dario, Zuolo, Michele, Rigamonti, Marco, Ghazouani, Omar, Galleano, Raffaele, Percivale, Andrea, Tirloni, Luca, Moraldi, Luca, Fabbri, Nicolò, Feo, Carlo Vittorio, Colombo, Samuele, Merlini, Ilenia, Di Saverio, Salomone, Barbato, Giuseppe, Coratti, Francesco, Formisano, Giampaolo, Bianchi, Paolo Pietro, Bengala, Carmelo, Coratti, Andrea, Dorma, Maria Pia Federica, Abu Hilal, Mohamnad, and Di Benedetto, Fabrizio

Published
2024
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2. The COVID - AGICT study: COVID–19 and advanced gastro-intestinal cancer surgical treatment. A multicentric Italian study on the SARS-CoV-2 pandemic impact on gastro-intestinal cancers surgical treatment during the 2020. Analysis of perioperative and short-term oncological outcomes

Author

Franco, Lorenzo De, Benigni, Roberto, Tribuzi, Angela, Marra, Ubaldo, Di Marino, Michele, Cova, Chiara, Bianchi, Beatrice, Nobile, Sara, Zorcolo, Luigi, Lisi, Giorgio, Allisiardi, Fabrizio, Grieco, Michele, Righetti, Carolina, Frisini, Marco, Brolese, Alberto, Grassia, Michele, Lucchi, Andrea, Bagaglini, Giulia, Sica, Giuseppe S., Manara, Michele, Turati, Luca, Macone, Lorenzo, Carminati, Roberta, Mariani, Pierpaolo, Rizzo, Gianluca, Coco, Claudio, Pennella, Francesca Pennetti, Rondelli, Fabio, Romano, Lucia, Giuliani, Antonio, Palaia, Raffaele, Belli, Andrea, Albino, Vittorio, Leongito, Maddalena, David, Giulia, Misitano, Pasquale, Pasulo, Silvia, Baiocchi, Gian Luca, La Mendola, Roberta, Hilal, Mohamnad Abu, Baldari, Ludovica, Cassinotti, Elisa, Boni, Luigi, Capolupo, Gabriella Teresa, Caricato, Marco, Pinotti, Enrico, Montuori, Mauro, Bombardini, Cristina, Anania, Gabriele, Dibra, Rigers, Martines, Gennaro, Solaini, Leonardo, Ercolani, Giorgio, Oliva, Renato, Carati, Maria Vittoria, Grazi, Gian Luca, Ghio, Giacomo, Marchegiani, Francesco, Pucciarelli, Salvatore, La Torre, Filippo, Iannone, Immacolata, Krizzuk, Dimitri, Sammartino, Francesco, Catalano, Giorgia, Strignano, Paolo, Romagnoli, Renato, Piccione, Domenico, Nardo, Bruno, Reddavid, Rossella, Degiuli, Maurizio, Gerosa, Martino, Maggioni, Dario, Zuolo, Michele, Rigamonti, Marco, Ghazouani, Omar, Galleano, Raffaele, Percivale, Andrea, Tirloni, Luca, Moraldi, Luca, Fabbri, Nicolò, Feo, Carlo Vittorio, Colombo, Samuele, Di Saverio, Salomone, Barbato, Giuseppe, Coratti, Francesco, Sagnotta, Andrea, Mancini, Stefano, Cillara, Nicola, Deserra, Antonello, Cannavera, Alessandro, Formisano, Giampaolo, Giuliani, Giuseppe, Guerra, Francesco, Messinese, Simona, Santelli, Francesco, Salvischiani, Lucia, Esposito, Sofia, Ferraro, Luca, Esposito, Alessandro, De Pastena, Matteo, Rega, Daniela, Delrio, Paolo, La Raja, Carlotta, Spinelli, Antonino, Massaron, Simonetta, De Nardi, Paola, Kauffmann, Emanuele Federico, Boggi, Ugo, Deidda, Simona, Restivo, Angelo, Marano, Alessandra, Borghi, Felice, Piccoli, Micaela, Depalma, Norma, D'Ugo, Stefano, Spampinato, Marcello, Cozzani, Federico, Del Rio, Paolo, Marcellinaro, Rosa, Carlini, Massimo, De Rosa, Raffaele, Scabini, Stefano, Maiello, Fabio, Polastri, Roberto, Turri, Giulia, Pedrazzani, Corrado, Zese, Monica, Parini, Dario, Casaril, Andrea, Moretto, Gianluigi, De Leo, Antonio, Catarci, Marco, Trapani, Renza, Zonta, Sandro, Marsanic, Patrizia, Muratore, Andrea, Di Franco, Gregorio, Morelli, Luca, Coppola, Alessandro, Caputo, Damiano, Andreuccetti, Jacopo, Pignata, Giusto, Mastrangelo, Laura, Jovine, Elio, Mazzola, Michele, Ferrari, Giovanni, Mariani, Lorenzo, Ceccarelli, Graziano, Giuseppe, Rocco, Bolzon, Stefano, Grasso, Mariateresa, Testa, Silvio, Germani, Paola, de Manzini, Nicolò, Langella, Serena, Ferrero, Alessandro, Coletta, Diego, Bianchi, Paolo Pietro, Bengala, Carmelo, and Coratti, Andrea

Published
2023
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3. Plexiform Fibromyxoma in the Stomach: Immunohistochemical Profile and Comprehensive Genetic Characterization

Author

Di Mauro, Annabella, primary, Rega, Rosalia Anna, additional, Leongito, Maddalena, additional, Albino, Vittorio, additional, Palaia, Raffaele, additional, Gualandi, Alberto, additional, Belli, Andrea, additional, D’Arbitrio, Imma, additional, Moccia, Pasquale, additional, Tafuto, Salvatore, additional, Chiara, Annarosaria De, additional, Ottaiano, Alessandro, additional, and Ferrara, Gerardo, additional

Published
2024
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4. The Pan - COVID - AGICT Study. The impact of COVID-19 pandemic on surgically treated pancreatic cancer patients. A multicentric Italian study.

Author

Dorma, Maria Pia Federica, primary, Giuliani, Giuseppe, additional, Guerra, Francesco, additional, Santelli, Francesco, additional, Esposito, Alessandro, additional, De Pastena, Matteo, additional, Turri, Giulia, additional, Pedrazzani, Corrado, additional, Kauffmann, Emanuele Federico, additional, Boggi, Ugo, additional, Solaini, Leonardo, additional, Ercolani, Giorgio, additional, Mastrangelo, Laura, additional, Jovine, Elio, additional, Di Franco, Gregorio, additional, Morelli, Luca, additional, Mazzola, Michele, additional, Ferrari, Giovanni, additional, Langella, Serena, additional, Ferrero, Alessandro, additional, La Mendola, Roberta, additional, Abu Hilal, Mohamnad, additional, Depalma, Norma, additional, D’Ugo, Stefano, additional, Spampinato, Marcello Giuseppe, additional, Frisini, Marco, additional, Brolese, Alberto, additional, Palaia, Raffaele, additional, Belli, Andrea, additional, Cillara, Nicola, additional, Deserra, Antonello, additional, Cannavera, Alessandro, additional, Sagnotta, Andrea, additional, Mancini, Stefano, additional, Pinotti, Enrico, additional, Montuori, Mauro, additional, Coppola, Alessandro, additional, Di Benedetto, Fabrizio, additional, Coratti, Andrea, additional, Cova, Chiara, additional, Bianchi, Beatrice, additional, Nobile, Sara, additional, Maruccio, Martina, additional, Faustini, Federico, additional, Hilal, Mohamnad Abu, additional, Pecora, Irene, additional, Messinese, Simona, additional, Salvischiani, Lucia, additional, Esposito, Sofia, additional, Ferraro, Luca, additional, Rega, Daniela, additional, Delrio, Paolo, additional, La Raja, Carlotta, additional, Spinelli, Antonino, additional, Massaron, Simonetta, additional, De Nardi, Paola, additional, Deidda, Simona, additional, Restivo, Angelo, additional, Marano, Alessandra, additional, Borghi, Felice, additional, Piccoli, Micaela, additional, Cozzani, Federico, additional, Del Rio, Paolo, additional, Marcellinaro, Rosa, additional, Carlini, Massimo, additional, De Rosa, Raffaele, additional, Scabini, Stefano, additional, Maiello, Fabio, additional, Polastri, Roberto, additional, Zese, Monica, additional, Parini, Dario, additional, Casaril, Andrea, additional, Moretto, Gianluigi, additional, De Leo, Antonio, additional, Catarci, Marco, additional, Trapani, Renza, additional, Zonta, Sandro, additional, Marsanic, Patrizia, additional, Muratore, Andrea, additional, Caputo, Damiano, additional, Andreuccetti, Jacopo, additional, Pignata, Giusto, additional, Mariani, Lorenzo, additional, Ceccarelli, Graziano, additional, Giuseppe, Rocco, additional, Bolzon, Stefano, additional, Grasso, Mariateresa, additional, Testa, Silvio, additional, Germani, Paola, additional, de Manzini, Nicolò, additional, Coletta, Diego, additional, De Franco, Lorenzo, additional, Benigni, Roberto, additional, Tribuzi, Angela, additional, Marra, Ubaldo, additional, Di Marino, Michele, additional, Zorcolo, Luigi, additional, Lisi, Giorgio, additional, Allisiardi, Fabrizio, additional, Grieco, Michele, additional, Righetti, Carolina, additional, Grassia, Michele, additional, Lucchi, Andrea, additional, Bagaglini, Giulia, additional, Sica, Giuseppe S., additional, Manara, Michele, additional, Turati, Luca, additional, Macone, Lorenzo, additional, Carminati, Roberta, additional, Mariani, Pierpaolo, additional, Rizzo, Gianluca, additional, Coco, Claudio, additional, Pennella, Francesca Pennetti, additional, Rondelli, Fabio, additional, Romano, Lucia, additional, Giuliani, Antonio, additional, Albino, Vittorio, additional, Leongito, Maddalena, additional, David, Giulia, additional, Misitano, Pasquale, additional, Pasulo, Silvia, additional, Baiocchi, Gian Luca, additional, Baldari, Ludovica, additional, Cassinotti, Elisa, additional, Boni, Luigi, additional, Capolupo, Gabriella Teresa, additional, Caricato, Marco, additional, Bombardini, Cristina, additional, Anania, Gabriele, additional, Dibra, Rigers, additional, Martines, Gennaro, additional, Oliva, Renato, additional, Carati, Maria Vittoria, additional, Grazi, Gian Luca, additional, Marchegiani, Francesco, additional, Spolverato, Gaya, additional, Celotto, Francesco, additional, Pucciarelli, Salvatore, additional, La Torre, Filippo, additional, Iannone, Immacolata, additional, Krizzuk, Dimitri, additional, Sammartino, Francesco, additional, Catalano, Giorgia, additional, Strignano, Paolo, additional, Romagnoli, Renato, additional, Piccione, Domenico, additional, Nardo, Bruno, additional, Reddavid, Rossella, additional, Degiuli, Maurizio, additional, Gerosa, Martino, additional, Maggioni, Dario, additional, Zuolo, Michele, additional, Rigamonti, Marco, additional, Ghazouani, Omar, additional, Galleano, Raffaele, additional, Percivale, Andrea, additional, Tirloni, Luca, additional, Moraldi, Luca, additional, Fabbri, Nicolò, additional, Feo, Carlo Vittorio, additional, Colombo, Samuele, additional, Merlini, Ilenia, additional, Di Saverio, Salomone, additional, Barbato, Giuseppe, additional, Coratti, Francesco, additional, Formisano, Giampaolo, additional, Bianchi, Paolo Pietro, additional, and Bengala, Carmelo, additional

Published
2024
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7. The COVID - AGICT study: COVID–19 and advanced gastro-intestinal cancer surgical treatment. A multicentric Italian study on the SARS-CoV-2 pandemic impact on gastro-intestinal cancers surgical treatment during the 2020. Analysis of perioperative and short-term oncological outcomes

Author

Giuliani, Giuseppe, primary, Guerra, Francesco, additional, Messinese, Simona, additional, Santelli, Francesco, additional, Salvischiani, Lucia, additional, Esposito, Sofia, additional, Ferraro, Luca, additional, Esposito, Alessandro, additional, De Pastena, Matteo, additional, Rega, Daniela, additional, Delrio, Paolo, additional, La Raja, Carlotta, additional, Spinelli, Antonino, additional, Massaron, Simonetta, additional, De Nardi, Paola, additional, Kauffmann, Emanuele Federico, additional, Boggi, Ugo, additional, Deidda, Simona, additional, Restivo, Angelo, additional, Marano, Alessandra, additional, Borghi, Felice, additional, Piccoli, Micaela, additional, Depalma, Norma, additional, D'Ugo, Stefano, additional, Spampinato, Marcello, additional, Cozzani, Federico, additional, Del Rio, Paolo, additional, Marcellinaro, Rosa, additional, Carlini, Massimo, additional, De Rosa, Raffaele, additional, Scabini, Stefano, additional, Maiello, Fabio, additional, Polastri, Roberto, additional, Turri, Giulia, additional, Pedrazzani, Corrado, additional, Zese, Monica, additional, Parini, Dario, additional, Casaril, Andrea, additional, Moretto, Gianluigi, additional, De Leo, Antonio, additional, Catarci, Marco, additional, Trapani, Renza, additional, Zonta, Sandro, additional, Marsanic, Patrizia, additional, Muratore, Andrea, additional, Di Franco, Gregorio, additional, Morelli, Luca, additional, Coppola, Alessandro, additional, Caputo, Damiano, additional, Andreuccetti, Jacopo, additional, Pignata, Giusto, additional, Mastrangelo, Laura, additional, Jovine, Elio, additional, Mazzola, Michele, additional, Ferrari, Giovanni, additional, Mariani, Lorenzo, additional, Ceccarelli, Graziano, additional, Giuseppe, Rocco, additional, Bolzon, Stefano, additional, Grasso, Mariateresa, additional, Testa, Silvio, additional, Germani, Paola, additional, de Manzini, Nicolò, additional, Langella, Serena, additional, Ferrero, Alessandro, additional, Coletta, Diego, additional, Bianchi, Paolo Pietro, additional, Bengala, Carmelo, additional, Coratti, Andrea, additional, Franco, Lorenzo De, additional, Benigni, Roberto, additional, Tribuzi, Angela, additional, Marra, Ubaldo, additional, Di Marino, Michele, additional, Cova, Chiara, additional, Bianchi, Beatrice, additional, Nobile, Sara, additional, Zorcolo, Luigi, additional, Lisi, Giorgio, additional, Allisiardi, Fabrizio, additional, Grieco, Michele, additional, Righetti, Carolina, additional, Frisini, Marco, additional, Brolese, Alberto, additional, Grassia, Michele, additional, Lucchi, Andrea, additional, Bagaglini, Giulia, additional, Sica, Giuseppe S., additional, Manara, Michele, additional, Turati, Luca, additional, Macone, Lorenzo, additional, Carminati, Roberta, additional, Mariani, Pierpaolo, additional, Rizzo, Gianluca, additional, Coco, Claudio, additional, Pennella, Francesca Pennetti, additional, Rondelli, Fabio, additional, Romano, Lucia, additional, Giuliani, Antonio, additional, Palaia, Raffaele, additional, Belli, Andrea, additional, Albino, Vittorio, additional, Leongito, Maddalena, additional, David, Giulia, additional, Misitano, Pasquale, additional, Pasulo, Silvia, additional, Baiocchi, Gian Luca, additional, La Mendola, Roberta, additional, Hilal, Mohamnad Abu, additional, Baldari, Ludovica, additional, Cassinotti, Elisa, additional, Boni, Luigi, additional, Capolupo, Gabriella Teresa, additional, Caricato, Marco, additional, Pinotti, Enrico, additional, Montuori, Mauro, additional, Bombardini, Cristina, additional, Anania, Gabriele, additional, Dibra, Rigers, additional, Martines, Gennaro, additional, Solaini, Leonardo, additional, Ercolani, Giorgio, additional, Oliva, Renato, additional, Carati, Maria Vittoria, additional, Grazi, Gian Luca, additional, Ghio, Giacomo, additional, Marchegiani, Francesco, additional, Pucciarelli, Salvatore, additional, La Torre, Filippo, additional, Iannone, Immacolata, additional, Krizzuk, Dimitri, additional, Sammartino, Francesco, additional, Catalano, Giorgia, additional, Strignano, Paolo, additional, Romagnoli, Renato, additional, Piccione, Domenico, additional, Nardo, Bruno, additional, Reddavid, Rossella, additional, Degiuli, Maurizio, additional, Gerosa, Martino, additional, Maggioni, Dario, additional, Zuolo, Michele, additional, Rigamonti, Marco, additional, Ghazouani, Omar, additional, Galleano, Raffaele, additional, Percivale, Andrea, additional, Tirloni, Luca, additional, Moraldi, Luca, additional, Fabbri, Nicolò, additional, Feo, Carlo Vittorio, additional, Colombo, Samuele, additional, Di Saverio, Salomone, additional, Barbato, Giuseppe, additional, Coratti, Francesco, additional, Sagnotta, Andrea, additional, Mancini, Stefano, additional, and Formisano, Giampaolo, additional

Published
2023
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8. Electrochemotherapy in pancreatic adenocarcinoma treatment: pre-clinical and clinical studies

Author

Bimonte Sabrina, Leongito Maddalena, Granata Vincenza, Barbieri Antonio, Vecchio Vitale del, Falco Michela, Nasto Aurelio, Albino Vittorio, Piccirillo Mauro, Palaia Raffaele, Amore Alfonso, Giacomo Raimondo di, Lastoria Secondo, Setola Sergio Venanzio, Fusco Roberta, Petrillo Antonella, and Izzo Francesco

Subjects
electrochemotherapy, pancreatic carcinoma, bleomycin, pre-clinical study, clinical study, safety, efficacy, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Pancreatic adenocarcinoma is currently one of the deadliest cancers with high mortality rate. This disease leads to an aggressive local invasion and early metastases, and is poorly responsive to treatment with chemotherapy or chemo-radiotherapy. Radical resection is still the only curative treatment for pancreatic cancer, but it is generally accepted that a multimodality strategy is necessary for its management. Therefore, new alternative therapies have been considered for local treatment.

Published
2016
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10. Is There Indication for the Use of Biological Mesh in Cancer Patients?

Author

Patrone, Renato, primary, Leongito, Maddalena, additional, di Giacomo, Raimondo, additional, Belli, Andrea, additional, Palaia, Raffaele, additional, Amore, Alfonso, additional, Albino, Vittorio, additional, Piccirillo, Mauro, additional, Cutolo, Carmen, additional, Coluccia, Sergio, additional, Nasto, Aurelio, additional, Conzo, Giovanni, additional, Crispo, Anna, additional, Granata, Vincenza, additional, and Izzo, Francesco, additional

Published
2022
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11. Role of shrinkage in esophageal–gastric junction cancer.

Author

Leongito, Maddalena, Palaia, Raffaele, Casaretti, Rossana, Tatangelo, Fabiana, Foschini, Francesca, Di Mauro, Annabella, Belli, Andrea, and Albino, Vittorio

Subjects
*SURGICAL margin, *ESOPHAGOGASTRIC junction, *ESOPHAGUS, *PATHOLOGISTS
Abstract

The esophagus undergoes shrinkage after resection and fixation. The surgical in situ margin is greater than the specimen margin, measured by the pathologist. The length of disease‐free margins is critical to therapeutic planning. We propose specimen fixing to avoid discrepancies between the operative finding and the pathological result. Esophagus undergoes shrinkage after resection and fixation. The surgical in situ margin is greater than the specimen margin, measured by the pathologist. The length of disease‐free margins is critical to therapeutic planning. We propose specimen fixing. [ABSTRACT FROM AUTHOR]

Published
2023
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18. A Multicenter Randomized Controlled Prospective Study to Assess Efficacy of Laparoscopic Electrochemotherapy in the Treatment of Locally Advanced Pancreatic Cancer

Author

Izzo, Francesco, primary, Granata, Vincenza, additional, Fusco, Roberta, additional, D’Alessio, Valeria, additional, Petrillo, Antonella, additional, Lastoria, Secondo, additional, Piccirillo, Mauro, additional, Albino, Vittorio, additional, Belli, Andrea, additional, Nasti, Guglielmo, additional, Avallone, Antonio, additional, Patrone, Renato, additional, Grassi, Francesca, additional, Leongito, Maddalena, additional, and Palaia, Raffaele, additional

Published
2021
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22. Laparocopic ventral hernia repair with primary transparietal closure of the hernial defect

Author

Rea Roberto, Falco Paolo, Izzo Domenico, Leongito Maddalena, and Amato Bruno

Subjects
Surgery, RD1-811
Abstract

Abstract Background The treatment of ventral hernias is still a subject of debate. The affixing of a prosthesis and the subsequent introduction of laparoscopic treatment have reduced complications and recurrences. The high incidence of seromas and high costs remain open problems. Methods At our Department between January 2008 and December 2011, 87 patients (43 over 65 years), out of a total of 132, with defects of wall whose major axis was less than 10 cm, or minor and multiple defects (Swiss-cheese defect) on an axis not exceeding 12 cm underwent laparoscopic ventral hernia repair (LVHR) with primary and transparietal closure of the hernial defect. Through small incisions in the skin we proceeded to close the parietal defect with sutures tied outside. Then the mesh was fixed as usual with double row of stitches and an overlap of 3-5cm. Results In all patients, 43 of them elderly, surgery was successfully conducted. The juxtaposition of the edges of the hernial defect has not been time consuming and has not developed new complications. The postoperative course was uneventful, with discharge on the third day, except in 5 patients. Were observed only small gaps and not the formation of large seromas. There were no infections wall. We do not have relapses, but some small and asymptomatic solutions continuously up to 2 cm at the sonographic study. In elderly patients the absence of dead space and the feeling of greater stability of the wall, early mobilization and pain control have facilitated the post-operative course. Conclusions The positioning of sutures transcutaneous is simple and effective, the reduced incidence of seromas and the greater stability of the wall suggest to adopt this procedure fully. The possibility to close the margins of the defect may allow to change the size and setting of the mesh, since the absence of dead space allows to download physiologically tensions of the wall.

Published
2012
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23. Robotic surgery of gallbladder cancer

Author

Belli, Andrea, primary, Patrone, Renato, additional, Albino, Vittorio, additional, Leongito, Maddalena, additional, Piccirillo, Mauro, additional, Granata, Vincenza, additional, Pasta, Gilda, additional, Palaia, Raffaele, additional, and Izzo, Francesco, additional

Published
2020
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27. The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells

Author

Bimonte, Sabrina, Barbieri, Antonio, Leongito, Maddalena, Palma, Giuseppe, del Vecchio, Vitale, Falco, Michela, Palaia, Raffaele, Albino, Vittorio, Piccirillo, Mauro, Amore, Alfonso, Petrillo, Antonella, Granata, Vincenza, and Izzo, Francesco

Subjects
Article Subject
Abstract

Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells.

Published
2016
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28. The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells

Author

Bimonte, Sabrina, Leongito, Maddalena, Barbieri, Antonio, del Vecchio, Vitale, Falco, Michela, Giudice, Aldo, Palaia, Raffaele, Albino, Vittorio, Di Giacomo, Raimondo, Petrillo, Antonella, Granata, Vincenza, and Izzo, Francesco

Subjects
Article Subject, digestive system diseases
Abstract

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide malignancy and the third leading cause of cancer death in patients. Several studies demonstrated that hepatic cancer stem cells (HCSCs), also called tumor-initiating cells, are involved in regulation of HCC initiation, tumor progression, metastasis development, and drug resistance. Despite the extensive research, the underlying mechanisms by which HCSCs are regulated remain still unclear. MicroRNAs (miRNAs) are able to regulate a lot of biological processes such as self-renewal and pluripotency of HCSCs, representing a new promising strategy for treatment of HCC chemotherapy-resistant tumors. In this review, we synthesize the latest findings on therapeutic regulation of HCSCs by miRNAs, in order to highlight the perspective of novel miRNA-based anticancer therapies for HCC treatment.

Published
2016
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30. Uncommon neoplasms of the biliary tract: radiological findings

Author

Granata, Vincenza, primary, Fusco, Roberta, additional, Catalano, Orlando, additional, Filice, Salvatore, additional, Avallone, Antonio, additional, Piccirillo, Mauro, additional, Leongito, Maddalena, additional, Palaia, Raffaele, additional, Grassi, Roberto, additional, Izzo, Francesco, additional, and Petrillo, Antonella, additional

Published
2017
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33. Il ruolo dell'ecografia endoanale nella riduzione delle recidive di fistole anali

Author

MILONE, MARCO, PESCE, GIUSEPPE, LEONGITO, MADDALENA, MILONE, FRANCESCO, Milone, Marco, Pesce, Giuseppe, Leongito, Maddalena, and Milone, Francesco

Subjects
Surgery
Abstract

The aim of surgical treatment of fistula-in-ano is to eradicate the suppurative process permanently without compromising faecal continence. The appearance of a recurrence of fistula-in-ano is often due to non-identification of the internal opening by the surgeon, and to the presence of complex fistulae. We evaluated the clinical course of 214 patients in a randomised. controlled trial with respect to the recurrence rate of anal fistula with or without preoperative endoanal ultrasonography. In this study we demonstrate that endoanal ultrasonography was the most accurate diagnostic modality for detecting internal opening and complex fistulae. Therefore, endoanal ultrasonography is reliable and useful in the preoperative assessment of anal fistula, and particularly for decreasing the recurrence rate of this disease.

Published
2009

34. Electrochemotherapy

Author

Tafuto, Salvatore, von Arx, Claudia, De Divitiis, Chiara, Tracey, Maura Claire, Granata, Vincenza, Palaia, Raffaele, Albino, Vittorio, Leongito, Maddalena, and Izzo, Francesco

Subjects
Cancer Research, Oncology
Published
2014
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35. Induction of VX2 para-renal carcinoma in rabbits: generation of animal model for loco-regional treatments of solid tumors

Author

Bimonte, Sabrina, primary, Leongito, Maddalena, additional, Piccirillo, Mauro, additional, Tamma, Maria Luisa, additional, Vallifuoco, Marianna, additional, Bracco, Adele, additional, Mancini, Antonio, additional, Di Napoli, Daniele, additional, Castaldo, Sigismondo, additional, Cozzolino, Santolo, additional, Iacobellis, Francesca, additional, Grassi, Roberto, additional, Granata, Vincenza, additional, Lastoria, Secondo, additional, Curley, Steven, additional, and Izzo, Francesco, additional

Published
2016
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37. Curcumin AntiCancer Studies in Pancreatic Cancer

Author

Bimonte, Sabrina, primary, Barbieri, Antonio, additional, Leongito, Maddalena, additional, Piccirillo, Mauro, additional, Giudice, Aldo, additional, Pivonello, Claudia, additional, de Angelis, Cristina, additional, Granata, Vincenza, additional, Palaia, Raffaele, additional, and Izzo, Francesco, additional

Published
2016
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39. Effectiveness of a drain in surgical treatment of sacrococcygeal pilonidal disease. Results of a randomized and controlled clinical trial on 803 consecutive patients

Author

Marco, Milone, Milone, Marco, Mario, Musella, Musella, Mario, Giuseppe, Salvatore, Salvatore, Giuseppe, Maddalena, Leongito, Leongito, Maddalena, Francesco, Milone, Milone, Francesco, Milone, M, Musella, Mario, Salvatore, G, Leongito, M, and Milone, Francesco

Subjects
Adult, Male, medicine.medical_specialty, surgical treatment, Treatment outcome, sacrococcygeal, Patient satisfaction, Pilonidal Sinus, Recurrence, medicine, Humans, Surgical treatment, Pilonidal disease, business.industry, Sacrococcygeal Region, Suture Techniques, Gastroenterology, drain, pilonidal disease, Wound infection, Surgery, Clinical trial, Treatment Outcome, Patient Satisfaction, Wound Infection, Drainage, Female, business
Abstract

PURPOSE: The aim of this study was to evaluate the influence of cavity drainage in the surgical treatment of sacrococcygeal pilonidal sinuses. METHODS: The study was prospectively carried out in 803 patients randomized into two groups of respectively 401 and 402 patients. In the first group, primary excision and closure were associated with drainage of the wound; in the second group, the wound was not drained. We have analyzed time off work, time to walk without pain, time to sitting on the toilet without pain, recurrences, and wound infections. We have also evaluated the satisfaction rate and esthetic results. RESULTS: On comparing time off work, time to walk without pain, and time to sitting on toilet without pain postoperatively, there were no significant differences between the two groups. A significant difference between the two groups with regard to wound infection rates (p = 0.5) and recurrence rates (p = 0.6) was not observed. In order to prevent prolonged inpatient stay and social intolerance, this study suggests that the post-operative period is tolerated by a few when a drain was used. The visual analog scale (VAS) in the drained group was 3.2 ± 0.9, and VAS in the non-drained group was 3.5 ± 0.9 with a significant statistical difference (p = 0.0001). As regards the cosmetic appearance of the scar after surgery, we achieved a high satisfaction rate among patients in either group with 82.9% good cosmetic results. CONCLUSIONS: The use of a drain, in our experience, appears to be useless in achieving a quick healing of the sacral wound; in addition, it has a low satisfaction rate.

Published
2011

40. Inhibitory effect of (−)-epigallocatechin-3-gallate and bleomycin on human pancreatic cancer MiaPaca-2 cell growth

Author

Bimonte, Sabrina, primary, Leongito, Maddalena, additional, Barbieri, Antonio, additional, Del Vecchio, Vitale, additional, Barbieri, Massimiliano, additional, Albino, Vittorio, additional, Piccirillo, Mauro, additional, Amore, Alfonso, additional, Di Giacomo, Raimondo, additional, Nasto, Aurelio, additional, Granata, Vincenza, additional, Petrillo, Antonella, additional, Arra, Claudio, additional, and Izzo, Francesco, additional

Published
2015
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41. Hepatocellular carcinoma and liver metastases: clinical data on a new dual-lumen catheter kit for surgical sealant infusion to prevent perihepatic bleeding and dissemination of cancer cells following biopsy and loco-regional treatments

Author

Izzo, Francesco, primary, Palaia, Raffaele, additional, Albino, Vittorio, additional, Amore, Alfonso, additional, di Giacomo, Raimondo, additional, Piccirillo, Mauro, additional, Leongito, Maddalena, additional, Nasto, Aurelio, additional, Granata, Vincenza, additional, Petrillo, Antonella, additional, and Lastoria, Secondo, additional

Published
2015
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45. The Mini-Gastric Bypass in the Management of Morbid Obesity in Prader-Willi Syndrome: A Viable Option?

Author

Musella, Mario, Milone, Marco, Leongito, Maddalena, Maietta, Paola, Bianco, Paolo, and Pisapia, Anna

Subjects
GASTRIC bypass, JEJUNUM surgery, BARIATRIC surgery, GENETIC disorders, CONGENITAL disorders, LAPAROSCOPY, BODY mass index
Abstract

Aims: To test the efficacy of the mini-gastric bypass (MGB) in the treatment of morbid obesity related to the Prader-Willi Syndrome (PWS). Patients and Methods: Three young male patients (mean age 15.6 years) complaining with PWS were treated by MGB with the aim to improve morbid obesity associated with the syndrome. Preoperative body mass index was 51 ± 4.13 kg/m2. Two patients suffered from both hypertension and frequent sleep apnea crises. The mean preoperative level of fasting plasma acyl ghrelin was 1417.26 ± 289.37 pg/ml. All patients underwent a laparoscopic MGB. Results: The postoperative period was uneventful and all patients were discharged on the fifth postoperative day. The patients suffering from both hypertension and respiratory crises are now free from receiving any therapeutic support. When measured, the postoperative level of fasting plasma acyl ghrelin decreased to 675.5, 524.6, and 353.1 pg/ml, respectively. An excess weight loss of 79% has been recorded at two years so far. To date, no nutritional impairment, weight regain, or need for revision surgery has been recorded. Conclusion: MGB appears to provide an effective weight reduction in patients suffering from PWS without determining significant nutritional impairment or weight regain. Larger studies are however required. [ABSTRACT FROM AUTHOR]

Published
2014
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46. Curcumin AntiCancer Studies in Pancreatic Cancer

Author

Mauro Piccirillo, Sabrina Bimonte, Cristina de Angelis, Antonio Barbieri, Claudia Pivonello, Francesco Izzo, Raffaele Palaia, Aldo Giudice, Vincenza Granata, Maddalena Leongito, Bimonte, Sabrina, Barbieri, Antonio, Leongito, Maddalena, Piccirillo, Mauro, Giudice, Aldo, Pivonello, Claudia, DE ANGELIS, Cristina, Granata, Vincenza, Palaia, Raffaele, and Izzo, Francesco

Subjects
0301 basic medicine, Angiogenesis, medicine.medical_treatment, pancreatic cancer, Apoptosis, Review, Pharmacology, Antioxidants, chemistry.chemical_compound, 0302 clinical medicine, Medicine, Pancrea, Nutrition and Dietetics, Neovascularization, Pathologic, Pancreatic Neoplasm, 030220 oncology & carcinogenesis, Antioxidant, lcsh:Nutrition. Foods and food supply, medicine.drug, Human, Curcumin, lcsh:TX341-641, Models, Biological, natural compound, 03 medical and health sciences, In vivo, Pancreatic cancer, Animals, Humans, Pancreas, Dietary Supplement, Chemotherapy, therapy, business.industry, Animal, Cancer, Apoptosi, Oxidative Stre, medicine.disease, Antineoplastic Agents, Phytogenic, Gemcitabine, Clinical trial, Pancreatic Neoplasms, Oxidative Stress, 030104 developmental biology, chemistry, Dietary Supplements, business, Food Science
Abstract

Pancreatic cancer (PC) is one of the deadliest cancers worldwide. Surgical resection remains the only curative therapeutic treatment for this disease, although only the minority of patients can be resected due to late diagnosis. Systemic gemcitabine-based chemotherapy plus nab-paclitaxel are used as the gold-standard therapy for patients with advanced PC; although this treatment is associated with a better overall survival compared to the old treatment, many side effects and poor results are still present. Therefore, new alternative therapies have been considered for treatment of advanced PC. Several preclinical studies have demonstrated that curcumin, a naturally occurring polyphenolic compound, has anticancer effects against different types of cancer, including PC, by modulating many molecular targets. Regarding PC, in vitro studies have shown potent cytotoxic effects of curcumin on different PC cell lines including MiaPaCa-2, Panc-1, AsPC-1, and BxPC-3. In addition, in vivo studies on PC models have shown that the anti-proliferative effects of curcumin are caused by the inhibition of oxidative stress and angiogenesis and are due to the induction of apoptosis. On the basis of these results, several researchers tested the anticancer effects of curcumin in clinical trials, trying to overcome the poor bioavailability of this agent by developing new bioavailable forms of curcumin. In this article, we review the results of pre-clinical and clinical studies on the effects of curcumin in the treatment of PC.

Published
2016

47. Induction of VX2 para-renal carcinoma in rabbits: generation of animal model for loco-regional treatments of solid tumors

Author

Roberto Grassi, Daniele Di Napoli, Vincenza Granata, Steven A. Curley, Maria Luisa Tamma, S. Castaldo, Francesca Iacobellis, A. Bracco, S. Cozzolino, Sabrina Bimonte, Marianna Vallifuoco, Francesco Izzo, Secondo Lastoria, Maddalena Leongito, Antonio Mancini, Mauro Piccirillo, Bimonte, Sabrina, Leongito, Maddalena, Piccirillo, Mauro, Luisa Tamma, Maria, Vallifuoco, Marianna, Bracco, Adele, Mancini, Antonio, Di Napoli, Daniele, Castaldo, Sigismondo, Cozzolino, Santolo, Iacobellis, Francesca, Grassi, Roberto, Granata, Vincenza, Lastoria, Secondo, Curley, Steven, and Izzo., Francesco

Subjects
Cancer Research, Pathology, medicine.medical_specialty, Epidemiology, Short Report, Hindlimb, Rabbit, Kidney, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Animal model, medicine, VX2, business.industry, Ultrasound, Cancer, Histology, medicine.disease, Infectious Diseases, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Histopathology, Rabbits, business, Para-renal neoplasm, Renal carcinoma
Abstract

BACKGROUND: Animal models of para-renal cancer can provide useful information for the evaluation of tumor response to loco-regional therapy experiments in solid tumors. The aim of our study was to establish a rabbit para-renal cancer model using locally implanted VX2 tumors. METHODS: In order to generate a rabbit model of para-renal cancer, we established four hind limb donor rabbits by using frozen VX2 tumor samples. Following inoculation, rabbits were monitored for appetite and signs of pain. Viable tumors appeared as palpable nodules within 2 weeks of inoculation. Tumor growth was confirmed in all rabbits by high-resolution ultrasound analysis and histology. Once tumor growth was established, hind limb tumors extraction was used for tumor line propagation and para-renal tumor creation. Twenty-one rabbit models bearing para-renal cancer were established by implanting VX2 tumor into the para-renal capsula. Tumors developed into discreet 2-3 cm nodules within 1-3 weeks of implantation. Serial renal ultrasonography follow-up, starting 1 week after tumor implantation, was performed. Two weeks after tumor implantation, rabbits were euthanized and tumors and other organs were collected for histopathology. RESULTS: Tumor growth after VX2 tumor fragment implantation was confirmed in all rabbits by high-resolution ultrasound (US) imaging examinations of the para-renal regions and was measured with digital caliper. The para-renal injection of VX2 tumor fragments, achieved tumor growth in 100% of cases. All data were confirmed by histological analysis. CONCLUSIONS: We generated for the first time, a model of para-renal cancer by surgical tumor implantation of VX2 frozen tumor fragments into rabbit's para-renal region. This method minimizes the development of metastases and the use of non-necrotic tumors and will optimize the evaluation of tumor response to loco-regional therapy experiments. Background: Animal models of para-renal cancer can provide useful information for the evaluation of tumor response to loco-regional therapy experiments in solid tumors. The aim of our study was to establish a rabbit para-renal cancer model using locally implanted VX2 tumors. Methods: In order to generate a rabbit model of para-renal cancer, we established four hind limb donor rabbits by using frozen VX2 tumor samples. Following inoculation, rabbits were monitored for appetite and signs of pain. Viable tumors appeared as palpable nodules within 2 weeks of inoculation. Tumor growth was confirmed in all rabbits by high-resolution ultrasound analysis and histology. Once tumor growth was established, hind limb tumors extraction was used for tumor line propagation and para-renal tumor creation. Twenty-one rabbit models bearing para-renal cancer were established by implanting VX2 tumor into the para-renal capsula. Tumors developed into discreet 2-3 cm nodules within 1-3 weeks of implantation. Serial renal ultrasonography follow-up, starting 1 week after tumor implantation, was performed. Two weeks after tumor implantation, rabbits were euthanized and tumors and other organs were collected for histopathology. Results: Tumor growth after VX2 tumor fragment implantation was confirmed in all rabbits by high-resolution ultrasound (US) imaging examinations of the para-renal regions and was measured with digital caliper. The para-renal injection of VX2 tumor fragments, achieved tumor growth in 100% of cases. All data were confirmed by histological analysis. Conclusions: We generated for the first time, a model of para-renal cancer by surgical tumor implantation of VX2 frozen tumor fragments into rabbit's para-renal region. This method minimizes the development of metastases and the use of non-necrotic tumors and will optimize the evaluation of tumor response to loco-regional therapy experiments.

Published
2016

48. Uncommon neoplasms of the biliary tract: radiological findings

Author

Antonella Petrillo, Orlando Catalano, Salvatore Filice, Maddalena Leongito, Roberta Fusco, Mauro Piccirillo, Antonio Avallone, Raffaele Palaia, Francesco Izzo, Roberto Grassi, Vincenza Granata, Granata, Vincenza, Fusco, Roberta, Catalano, Orlando, Filice, Salvatore, Avallone, Antonio, Piccirillo, Mauro, Leongito, Maddalena, Palaia, Raffaele, Grassi, Roberto, Izzo, Francesco, and Petrillo, Antonella

Subjects
Adult, Male, medicine.medical_specialty, 030218 nuclear medicine & medical imaging, Biliary disease, Lesion, 03 medical and health sciences, 0302 clinical medicine, Retrospective Studie, medicine, Humans, Radiology, Nuclear Medicine and imaging, Aged, Retrospective Studies, Ultrasonography, Aged, 80 and over, Biliary tract neoplasm, Full Paper, medicine.diagnostic_test, business.industry, Incidence, Gallbladder, Cancer, Magnetic resonance imaging, General Medicine, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Complex Cystic Lesion, Biliary Tract Neoplasms, medicine.anatomical_structure, Biliary Tract Neoplasm, Biliary tract, 030220 oncology & carcinogenesis, Female, Radiology, medicine.symptom, Tomography, X-Ray Computed, business, Human
Abstract

Objective: To report our cancer centre experience in the biliary tumours incidence other than cholangiocellular- carcinoma, emphasizing the radiological features. Methods: 197 patients with biliary disease undergoing Gd-EOB-DTPA-enhanced MRI were reviewed. Four radiologists evaluated retrospectively size, structure, anatomical site and signal intensity of lesions on MRI. Enhancement-pattern during the arterial-, portal-And late-phase on ultrasound, CT and MR study was assessed as well as the enhancement pattern during the hepatobiliary- phase on MRI. Results: 23 patients were selected. The lesion was intraductal in 5 cases, periductal in 14 and intrahepatic in 4. 16 lesions were solid, 5 uniloculated cystic and 2 complex cystic. In five patients the lesion was simple cyst, with a signal intensity in T1weighted (T1W) and T2weighted (T2W) similar to the gallbladder. In two patients with complex cystic lesion, the solid component was heterogeneously hypointense in T1W, hyperintense in T2W with a restricted diffusion. The solid component showed heterogeneous contrast-enhancement on CT, MR and ultrasound. The tumour was intrahepatic in two patients, with signal hypointense in T1W and hyperintense in T2W. Diffusion was restricted. The lesions showed heterogeneous contrast-enhancement. The periductal lesions were hypointense in T1W, hyperintense in T2W with restricted diffusion. The lesion showed progressive contrast-enhancement. Peribiliary melanoma was hyperintense in T1W, hyperintense in T2W with restricted diffusion and progressively contrast-enhanced. Conclusion: Biliary tumours can have a wide spectrum of radiologic appearances and consequently represent a diagnostic challenge for the radiologist. Advances in knowledge: MRI is the technique of choice in diagnosing biliary tumours, including rare (non-CCC) tumours.

Published
2017
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49. Radio-frequency ablation-based studies on VX2rabbit models for HCC treatment

Author

Cristina de Angelis, Sabrina Bimonte, Vincenza Granata, Claudia Pivonello, Mauro Piccirillo, Francesco Izzo, Maddalena Leongito, Bimonte, Sabrina, Leongito, Maddalena, Piccirillo, Mauro, DE ANGELIS, Cristina, Pivonello, Claudia, Granata, Vincenza, and Izzo, Francesco

Subjects
RFA, Cancer Research, medicine.medical_specialty, Cirrhosis, Hepatocellular carcinoma, Radiofrequency ablation, Epidemiology, medicine.medical_treatment, Review, Gastroenterology, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, 0302 clinical medicine, In vivo, law, Internal medicine, Medicine, business.industry, Cancer, medicine.disease, Vx2 tumors, digestive system diseases, Transplantation, surgical procedures, operative, Infectious Diseases, Oncology, 030220 oncology & carcinogenesis, Residual tumor, Percutaneous ethanol injection, business, Adjuvant
Abstract

Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide with high morbidity, mortality and increasing incidence. It is of note that the main curative therapies for HCC are hepatic resection and transplantation although the majority of patients at the time of presentation are not eligible for resection or orthotopic liver transplantation (OLT) due to the underlying cirrhosis. Currently, a variety of loco-regional therapies, including radiofrequency ablation (RFA), percutaneous ethanol injection (PEI), microwave coagulation therapy (MCT), transarterial chemoembolization (TACE) and others, have been developed as alternative treatment options for HCC. Among these techniques, RFA is currently the most widely used treatment, due to its several advantages, such as safety and efficacy. To date, the effectiveness of RFA for HCC is reduced by the presence of residual tumor as a consequence of insufficient treatment. In order to ameliorate the effects of RFA on HCC, several in vivo studies, have been performed on its application as single or in combination treatment with drugs or others loco-regional therapies, by using rabbit VX2 liver model. This represents an ideal model of liver cancers and is widely used for imaging and other experimental studies due to the rapid growth of these tumors and their similarity to human hepatocellular carcinoma. In order to elucidate the therapeutic potential of RFA with adjuvant treatments for HCC, we reviewed the latest findings on the RFA-based studies in rabbit VX2 hepatocarcinoma models.

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50. An overview of pre-clinical studies on the effects of (-)-epigallocatechin-3-gallate, a catechin found in green tea, in treatment of pancreatic cancer

Author

Bimonte S, Cascella M, Leongito M, Palaia R, Caliendo D, Izzo F, and Cuomo A

Subjects
Animals, Antineoplastic Agents, Phytogenic administration & dosage, Antineoplastic Agents, Phytogenic pharmacokinetics, Apoptosis drug effects, Biological Availability, Catechin administration & dosage, Catechin pharmacokinetics, Catechin pharmacology, Disease Progression, Disease-Free Survival, Humans, Pancreatic Neoplasms pathology, Signal Transduction drug effects, Tea chemistry, Antineoplastic Agents, Phytogenic pharmacology, Catechin analogs & derivatives, Pancreatic Neoplasms drug therapy
Abstract

Human pancreatic cancer is one of the leading causes of mortality and morbidity worldwide. Despite surgical resection remains the only curative therapeutic treatment for this disease, only the minority of patients can be resected due to late diagnosis. Recently, new chemotherapy schemes with the combination of different drugs have been shown to improve disease-free survival, although best results were obtained mostly as neoadjuvant chemotherapy in the minority of patients with resectable tumor. Consequently, there is stimulated interest in new chemotherapeutic approaches and alternative medicines. Several studies showed that the use of natural compounds, such as phytochemicals, represents a promising strategy for pancreatic cancer treatment. One popular phytochemical with great anticancer properties, is the (-)-epigallocate-chin3-O-gallate (EGCG), the most abundant catechin found in green tea. Accumulating evidences demonstrated that EGCG induces apoptosis and inhibits tumor progression by modulating different signaling pathways in pancreatic cancer. For these encouraging results, this catechin is currently used in clinical trials for treatment of various type of cancer and other diseases, although its poor bioavailability and poor stability represent severe limitations. Therefore, many researchers tried to develop a new strategy based of the use of nanotechnology which increases EGCG stability and bioavailability and simultaneously targets cancer cells in order to improve its anti-tumor effects. The aim of this article is to dissect the use of EGCG for management of pancreatic cancer, by reviewing the pre-clinical studies reported in literature.

Published
2017
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