7 results on '"Leong, Kin Wah"'
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2. Oncologist-led BRCA counselling improves access to cancer genetic testing in middle-income Asian country, with no significant impact on psychosocial outcomes
- Author
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Yoon, Sook-Yee, primary, Wong, Siu Wan, additional, Lim, Joanna, additional, Ahmad, Syuhada, additional, Mariapun, Shivaani, additional, Padmanabhan, Heamanthaa, additional, Hassan, Nur Tiara, additional, Lau, Shao Yan, additional, Ch'ng, Gaik-Siew, additional, Haniffa, Muzhirah, additional, Ong, Winnie P, additional, Rethanavelu, Kavitha, additional, Moey, Lip Hen, additional, Keng, Wee Teik, additional, Omar, Jamil, additional, Mohd Abas, Mohd Norazam, additional, Yong, Chee Meng, additional, Ramasamy, Vickneswaren, additional, Md Noor, Mohd Rushdan, additional, Aliyas, Ismail, additional, Lim, Michael C K, additional, Suberamaniam, Anuradha, additional, Mat Adenan, Noor Azmi, additional, Ahmad, Zatul Akmar, additional, Ho, Gwo Fuang, additional, Abdul Malik, Rozita, additional, Subramaniam, Suguna, additional, Khoo, Boom Ping, additional, Raja, Arivendran, additional, Chin, Yeung Sing, additional, Sim, Wee Wee, additional, Teh, Beng Hock, additional, Kho, Swee Kiong, additional, Ong, Eunice S E, additional, Voon, Pei Jye, additional, Ismail, Ghazali, additional, Lee, Chui Ling, additional, Abdullah, Badrul Zaman, additional, Loo, Kwong Sheng, additional, Lim, Chun Sen, additional, Lee, Saw Joo, additional, Lim, Keng Joo Lim, additional, Shafiee, Mohamad Nasir, additional, Ismail, Fuad, additional, Latiff, Zarina Abdul, additional, Ismail, Mohd Pazudin, additional, Mohamed Jamli, Mohamad Faiz, additional, Kumarasamy, Suresh, additional, Leong, Kin Wah, additional, Low, John, additional, Md Yusof, Mastura, additional, Ahmad Mustafa, Ahmad Muzamir, additional, Mat Ali, Nor Huda, additional, Makanjang, Mary, additional, Tayib, Shahila, additional, Cheah, Nellie, additional, Lim, Boon Kiong, additional, Fong, Chee Kin, additional, Foo, Yoke Ching, additional, Mellor Abdullah, Matin, additional, Tan, Teck Sin, additional, Chow, Doris S Y, additional, Ho, Kean Fatt, additional, Raman, Rakesh, additional, Radzi, Ahmad, additional, Deniel, Azura, additional, Teoh, Daren C Y, additional, Ang, Soo Fan, additional, Joseph, Joseph K, additional, Ng, Paul Hock Oon, additional, Tho, Lye-Mun, additional, Ahmad, Azura Rozila, additional, Muin, Ileena, additional, Bleiker, Eveline, additional, George, Angela, additional, Thong, Meow-Keong, additional, Woo, Yin Ling, additional, and Teo, Soo Hwang, additional
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- 2021
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3. Mortality outcomes and survival patterns of patients with myeloproliferative neoplasms in Malaysia.
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Yap, Yee Yee, Sathar, Jameela, Law, Kian Boon, MPN registry working group, Tan, Sen Mui, Lau, Ngee Siang, Ong, Tee Chuan, Goh, Ai Sim, Chew, Teng Keat, Lim, Soo Min, Toh, See Guan, Sim, Xavier Yoon Han, Menon, Padmini, Guan, Yong Khee, Husin, Azlan Bin, Wong, Lily Lee Lee, Chew, Lee Ping, Salleh, Sinari, Goh, Kim Yen, and Leong, Kin Wah
- Subjects
MYELOPROLIFERATIVE neoplasms ,SURVIVAL rate ,OVERALL survival ,MORTALITY ,BONE marrow - Abstract
Background: Prognostication of myeloproliferative neoplasm (MPN) has always been challenging, even with the advent of Janus kinase 2 (JAK2 V617F) molecular studies. The survival pattern of patients diagnosed with MPN in developing countries is still undetermined. Materials and methods: The national MPN registry conducted from 2009 to 2015 in Malaysia provided a comprehensive insight into the demographics, clinical characteristics and laboratory parameters of patients diagnosed with MPN nationwide. The study analysed the survival patterns and mortality outcomes and risk among 671 patients diagnosed with essential thrombocythaemia (ET), polycythaemia vera (PV), primary myelofibrosis (PMF) and unclassified MPN (MPN-U). Mortality status was traced and confirmed until the end of December 2018, with right censoring applied to patients alive beyond that. Results: The analysed cohort consisted of 283 (42.2%) ET, 269 (40.1%) PV, 62 (9.2%) PMF and 57 (8.5%) MPN-U incident cases with diagnosis made between 2007 and 2015. The majority of patients were male (52.3%) and Malay (48.9%), except for ET, in which the majority of patients were female (60.1%) and of Chinese origin (47.0%). Female patients were found to have significantly better overall survival (OS) rates in ET (p = 0.0285) and MPN-U (p = 0.0070). Patients with JAK2 V617F mutation were found to have marginally inferior OS over time. Multivariable Cox regression identified patients with increased age [hazard ratio (HR) 1.055, 95% CI 1.031; 1.064], reduced haemoglobin (HB) level (HR 0.886, 95% CI 0.831; 0.945, p = 0.0002), being male (HR 1.545, 95% CI 1.077; 2.217, p = 0.0182), and having MPN-U (HR 2.383, 95% CI 1.261; 4.503, p = 0.0075) and PMF (HR 1.975, 95% CI 1.054; 3.701, p = 0.0335) at increased risk for worse mortality outcomes. Conclusion: Myeloproliferative neoplasm reduces patient survival. The degree of impact on survival varies according to sub-type, sex, bone marrow fibrosis and HB levels. The JAK2 V617F mutation was not found to affect the survival pattern or mortality outcome significantly. [ABSTRACT FROM AUTHOR]
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- 2022
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4. Real-world experience of first-line afatinib in patients with EGFR-mutant advanced NSCLC: a multicenter observational study
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Ho, Gwo-Fuang, primary, Chai, Chee-Shee, additional, Alip, Adlinda, additional, Wahid, Mohd Ibrahim A., additional, Abdullah, Matin Mellor, additional, Foo, Yoke-Ching, additional, How, Soon-Hin, additional, Zaatar, Adel, additional, Lam, Kai-Seng, additional, Leong, Kin-Wah, additional, Low, John-Seng-Hooi, additional, Yusof, Mastura Md, additional, Lee, Erica Chai-Yong, additional, Toh, Yok-Yong, additional, and Liam, Chong-Kin, additional
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- 2019
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5. Oncologist-led BRCAcounselling improves access to cancer genetic testing in middle-income Asian country, with no significant impact on psychosocial outcomes
- Author
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Yoon, Sook-Yee, Wong, Siu Wan, Lim, Joanna, Ahmad, Syuhada, Mariapun, Shivaani, Padmanabhan, Heamanthaa, Hassan, Nur Tiara, Lau, Shao Yan, Ch'ng, Gaik-Siew, Haniffa, Muzhirah, Ong, Winnie P, Rethanavelu, Kavitha, Moey, Lip Hen, Keng, Wee Teik, Omar, Jamil, Mohd Abas, Mohd Norazam, Yong, Chee Meng, Ramasamy, Vickneswaren, Md Noor, Mohd Rushdan, Aliyas, Ismail, Lim, Michael C K, Suberamaniam, Anuradha, Mat Adenan, Noor Azmi, Ahmad, Zatul Akmar, Ho, Gwo Fuang, Abdul Malik, Rozita, Subramaniam, Suguna, Khoo, Boom Ping, Raja, Arivendran, Chin, Yeung Sing, Sim, Wee Wee, Teh, Beng Hock, Kho, Swee Kiong, Ong, Eunice S E, Voon, Pei Jye, Ismail, Ghazali, Lee, Chui Ling, Abdullah, Badrul Zaman, Loo, Kwong Sheng, Lim, Chun Sen, Lee, Saw Joo, Lim, Keng Joo Lim, Shafiee, Mohamad Nasir, Ismail, Fuad, Latiff, Zarina Abdul, Ismail, Mohd Pazudin, Mohamed Jamli, Mohamad Faiz, Kumarasamy, Suresh, Leong, Kin Wah, Low, John, Md Yusof, Mastura, Ahmad Mustafa, Ahmad Muzamir, Mat Ali, Nor Huda, Makanjang, Mary, Tayib, Shahila, Cheah, Nellie, Lim, Boon Kiong, Fong, Chee Kin, Foo, Yoke Ching, Mellor Abdullah, Matin, Tan, Teck Sin, Chow, Doris S Y, Ho, Kean Fatt, Raman, Rakesh, Radzi, Ahmad, Deniel, Azura, Teoh, Daren C Y, Ang, Soo Fan, Joseph, Joseph K, Ng, Paul Hock Oon, Tho, Lye-Mun, Ahmad, Azura Rozila, Muin, Ileena, Bleiker, Eveline, George, Angela, Thong, Meow-Keong, Woo, Yin Ling, and Teo, Soo Hwang
- Abstract
BackgroundIdentifying patients with BRCAmutations is clinically important to inform on the potential response to treatment and for risk management of patients and their relatives. However, traditional referral routes may not meet clinical needs, and therefore, mainstreaming cancer genetics has been shown to be effective in some high-income and high health-literacy settings. To date, no study has reported on the feasibility of mainstreaming in low-income and middle-income settings, where the service considerations and health literacy could detrimentally affect the feasibility of mainstreaming.MethodsThe Mainstreaming Genetic Counselling for Ovarian Cancer Patients (MaGiC) study is a prospective, two-arm observational study comparing oncologist-led and genetics-led counselling. This study included 790 multiethnic patients with ovarian cancer from 23 sites in Malaysia. We compared the impact of different method of delivery of genetic counselling on the uptake of genetic testing and assessed the feasibility, knowledge and satisfaction of patients with ovarian cancer.ResultsOncologists were satisfied with the mainstreaming experience, with 95% indicating a desire to incorporate testing into their clinical practice. The uptake of genetic testing was similar in the mainstreaming and genetics arm (80% and 79%, respectively). Patient satisfaction was high, whereas decision conflict and psychological impact were low in both arms of the study. Notably, decisional conflict, although lower than threshold, was higher for the mainstreaming group compared with the genetics arm. Overall, 13.5% of patients had a pathogenic variant in BRCA1or BRCA2,and there was no difference between psychosocial measures for carriers in both arms.ConclusionThe MaGiC study demonstrates that mainstreaming cancer genetics is feasible in low-resource and middle-resource Asian setting and increased coverage for genetic testing.
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- 2022
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6. Imatinib mesylate causes hypopigmentation in the skin
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Leong, Kin Wah, primary, Lee, Thoong Chow, additional, and Goh, Ai Sim, additional
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- 2004
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7. Oncologist-led BRCA counselling improves access to cancer genetic testing in middle-income Asian country, with no significant impact on psychosocial outcomes.
- Author
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Yoon SY, Wong SW, Lim J, Ahmad S, Mariapun S, Padmanabhan H, Hassan NT, Lau SY, Ch'ng GS, Haniffa M, Ong WP, Rethanavelu K, Moey LH, Keng WT, Omar J, Mohd Abas MN, Yong CM, Ramasamy V, Md Noor MR, Aliyas I, Lim MCK, Suberamaniam A, Mat Adenan NA, Ahmad ZA, Ho GF, Abdul Malik R, Subramaniam S, Khoo BP, Raja A, Chin YS, Sim WW, Teh BH, Kho SK, Ong ESE, Voon PJ, Ismail G, Lee CL, Abdullah BZ, Loo KS, Lim CS, Lee SJ, Lim KJL, Shafiee MN, Ismail F, Latiff ZA, Ismail MP, Mohamed Jamli MF, Kumarasamy S, Leong KW, Low J, Md Yusof M, Ahmad Mustafa AM, Mat Ali NH, Makanjang M, Tayib S, Cheah N, Lim BK, Fong CK, Foo YC, Mellor Abdullah M, Tan TS, Chow DSY, Ho KF, Raman R, Radzi A, Deniel A, Teoh DCY, Ang SF, Joseph JK, Ng PHO, Tho LM, Ahmad AR, Muin I, Bleiker E, George A, Thong MK, Woo YL, and Teo SH
- Subjects
- BRCA1 Protein genetics, BRCA2 Protein genetics, Counseling, Female, Genetic Counseling, Genetic Testing methods, Humans, Prospective Studies, Oncologists, Ovarian Neoplasms diagnosis, Ovarian Neoplasms epidemiology, Ovarian Neoplasms genetics
- Abstract
Background: Identifying patients with BRCA mutations is clinically important to inform on the potential response to treatment and for risk management of patients and their relatives. However, traditional referral routes may not meet clinical needs, and therefore, mainstreaming cancer genetics has been shown to be effective in some high-income and high health-literacy settings. To date, no study has reported on the feasibility of mainstreaming in low-income and middle-income settings, where the service considerations and health literacy could detrimentally affect the feasibility of mainstreaming., Methods: The Mainstreaming Genetic Counselling for Ovarian Cancer Patients (MaGiC) study is a prospective, two-arm observational study comparing oncologist-led and genetics-led counselling. This study included 790 multiethnic patients with ovarian cancer from 23 sites in Malaysia. We compared the impact of different method of delivery of genetic counselling on the uptake of genetic testing and assessed the feasibility, knowledge and satisfaction of patients with ovarian cancer., Results: Oncologists were satisfied with the mainstreaming experience, with 95% indicating a desire to incorporate testing into their clinical practice. The uptake of genetic testing was similar in the mainstreaming and genetics arm (80% and 79%, respectively). Patient satisfaction was high, whereas decision conflict and psychological impact were low in both arms of the study. Notably, decisional conflict, although lower than threshold, was higher for the mainstreaming group compared with the genetics arm. Overall, 13.5% of patients had a pathogenic variant in BRCA1 or BRCA2, and there was no difference between psychosocial measures for carriers in both arms., Conclusion: The MaGiC study demonstrates that mainstreaming cancer genetics is feasible in low-resource and middle-resource Asian setting and increased coverage for genetic testing., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2022
- Full Text
- View/download PDF
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