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25 results on '"Leonelli, D."'

1. Monolithic TCAD Simulation of Phase-Change Memory (PCM/PRAM) + Ovonic Threshold Switch (OTS) Selector Device

Author

Thesberg, M., Stanojevic, Z., Baumgartner, O., Kernstock, C., Leonelli, D., Barci, M., Wang, X., Zhou, X., Jiao, H., Donadio, G. L., Garbin, D., Witters, T., Kundu, S., Hody, H., Delhougne, R., Kar, G., and Karner, M.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science, Physics - Applied Physics
Abstract

Owing to the increasing interest in the commercialization of phase-change memory (PCM) devices, a number of TCAD models have been developed for their simulation. These models formulate the melting, amorphization and crystallization of phase-change materials as well as their extreme conductivity dependence on both electric field and temperature into a set of self-consistently-solved thermoelectric and phase-field partial-differential equations. However, demonstrations of the ability of such models to match actual experimental results are rare. In addition, such PCM devices also require a so-called selector device - such as an Ovonic Threshold Switching (OTS) device - in series for proper memory operation. However, monolithic simulation of both the PCM and OTS selector device in a single simulation is largely absent from the literature, despite its potential value for material- and design-space explorations. It is the goal of this work to first characterize a PCM device in isolation against experimental data, then to demonstrate the qualitative behavior of a simulated OTS device in isolation and finally to perform a single monolithic simulation of the PCM + OTS device within the confines of a commercially available TCAD solver: GTS Framework.

Published
2022
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6. Fabrication and Analysis of a Si/Si0.55Ge0.45 Heterojunction Line Tunnel FET

Author

WALKE, AM, VANDOOREN, A, ROOYACKERS, R, LEONELLI, D, HIKAVYY, A, LOO, R, VERHULST, AS, KAO, KH, HUYGHEBAERT, C, GROESENEKEN, G, RAO, VR, BHUWALKA, KK, HEYNS, MM, COLLAERT, N, and THEAN, AVY

Subjects
Line Tunneling, Gate Length And Width Dependence, Tfet Variability, Performance, Tfet Simulations, Field-Induced Quantum Confinement (Fiqc), Fiqc Effect, Tfet Fabrication, Tunnel Field Effect Transistor (Tfet), Strain
Abstract

This paper presents a new integration scheme to fabricate a Si/Si0.55Ge0.45 heterojunction line tunnel field effect transistor (TFET). The device shows an increase in tunneling current with gate length. The 1-mu m gate length device shows ON current in excess of 20 mu A/mu m at V-GS = V-DS = 1.2 V. Low-temperature measurements, performed to suppress trap-assisted tunneling (TAT), reveal the point subthreshold swing as low as 22 mV/dec at 78 K. Field-induced quantum confinement effects are found to increase the tunneling onset voltage by similar to 0.35 V. Variation of the tunneling onset voltage measured experimentally is correlated to variation in the pocket thickness and its doping concentration. Small geometry devices were found to be more susceptible to microvariations in the pocket thickness and doping concentration.

Published
2014
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13. Advancing CMOS beyond the Si roadmap with Ge and III/V devices

Author

Heyns, M., primary, Alian, A., additional, Brammertz, G., additional, Caymax, M., additional, Chang, Y.C., additional, Chu, L.K., additional, De Jaeger, B., additional, Eneman, G., additional, Gencarelli, F., additional, Groeseneken, G., additional, Hellings, G., additional, Hikavyy, A., additional, Hoffmann, T.Y., additional, Houssa, M., additional, Huyghebaert, C., additional, Leonelli, D., additional, Lin, D., additional, Loo, R., additional, Magnus, W., additional, Merckling, C., additional, Meuris, M., additional, Mitard, J., additional, Nyns, L., additional, Orzali, T., additional, Rooyackers, R., additional, Sioncke, S., additional, Soree, B., additional, Sun, X., additional, Vandooren, A., additional, Verhulst, A.S., additional, Vincent, B., additional, Waldron, N., additional, Wang, G., additional, Wang, W.E., additional, and Witters, L., additional

Published
2011
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16. Si-based tunnel field-effect transistors for low-power nano-electronics

Author

Verhulst, A.S., primary, Vandenberghe, W.G., additional, Leonelli, D., additional, Rooyackers, R., additional, Vandooren, A., additional, Zhuge, J., additional, Kao, K-H., additional, Soree, B., additional, Magnus, W., additional, Fischetti, M.V., additional, Pourtois, G., additional, Huyghebaert, C., additional, Huang, R., additional, Wang, Y., additional, De Meyer, K., additional, Dehaene, W., additional, Heyns, M.M., additional, and Groeseneken, G., additional

Published
2011
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24. Il differenziale nei costi del sistema sanitario pubblico nelle aree montane della Regione Molise

Author

Claudia SALVATORE, FORLEO M. DI NOCERA A. LEONELLI D. FRATANGELO P. ORTUSO F. SALVATORE C., FORLEO M., and Salvatore, Claudia

Abstract

Il contributo analizza i maggiori costi che le strutture sanitarie pubbliche della Regione Molise, situate in territori di montagna, devono sopportare per l'erogazione delle prestazioni sanitarie. L'analisi empirica svolta attraverso l'applicazione degli strumenti di contabilità analitica e di controllo di gestione ha evidenziato l'erogazione di prestazioni sanitarie in territori montuosi anche in condizioni di mancata efficienza, efficacia ed economicità.

25. Bioinformatic Mining and Structure-Activity Profiling of Baeyer-Villiger Monooxygenases from Mycobacterium tuberculosis.

Author

Tomas N, Leonelli D, Campoy M, Marthey S, Le NH, Rengel D, Martin V, Pál A, Korduláková J, Eynard N, Guillet V, Mourey L, Daffé M, Lemassu A, André G, and Marrakchi H

Subjects
Antitubercular Agents pharmacology, Computational Biology, Mixed Function Oxygenases chemistry, Mixed Function Oxygenases genetics, Mycobacterium tuberculosis genetics, Prodrugs
Abstract

Mycobacterium tuberculosis is the etiological agent of tuberculosis (TB), one of the deadliest infectious diseases. The alarming health context coupled with the emergence of resistant M. tuberculosis strains highlights the urgent need to expand the range of anti-TB antibiotics. A subset of anti-TB drugs in use are prodrugs that require bioactivation by a class of M. tuberculosis enzymes called Baeyer-Villiger monooxygenases (BVMOs), which remain understudied. To examine the prevalence and the molecular function of BVMOs in mycobacteria, we applied a comprehensive bioinformatic analysis that identified six BVMOs in M. tuberculosis, including Rv3083 (MymA), Rv3854c (EthA), Rv0565c, and Rv0892, which were selected for further characterization. Homology modeling and substrate docking analysis, performed on this subset, suggested that Rv0892 is closer to the cyclohexanone BVMO, while Rv0565c and EthA are structurally and functionally similar to MymA, which is by far the most prominent type I BVMO enzyme. Thanks to an unprecedented purification and assay optimization, biochemical studies confirmed that all four BVMOs display BV-oxygenation activity. We also showed that MymA displays a distinctive substrate preference that we further investigated by kinetic parameter determination and that correlates with in silico modeling. We provide insights into distribution of BVMOs and the structural basis of their substrate profiling, and we discuss their possible redundancy in M. tuberculosis, raising questions about their versatility in prodrug activation and their role in physiology and infection. IMPORTANCE Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the leading causes of death worldwide. The rise in drug resistance highlights the urgent need for innovation in anti-TB drug development. Many anti-TB drugs require bioactivation by Baeyer-Villiger monooxygenases (BVMOs). Despite their emerging importance, BVMO structural and functional features remain enigmatic. We applied a comprehensive bioinformatic analysis and confirmed the presence of six BVMOs in M. tuberculosis, including MymA, EthA, and Rv0565c-activators of the second-line prodrug ethionamide-and the novel BVMO Rv0892. Combining in silico characterization with in vitro validation, we outlined their structural framework and substrate preference. Markedly, MymA displayed an enhanced capacity and a distinct selectivity profile toward ligands, in agreement with its catalytic site topology. These features ground the molecular basis for structure-function comprehension of the specificity in these enzymes and expand the repertoire of BVMOs with selective and/or overlapping activity for application in the context of improving anti-TB therapy.

Published
2022
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