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279 results on '"Leone, Serena"'

1. The NEREA Augmented Observatory: an integrative approach to marine coastal ecology

Author

Campese, Lucia, Russo, Luca, Abagnale, Maria, Alberti, Adriana, Bachi, Giancarlo, Balestra, Cecilia, Bellardini, Daniele, Buondonno, Angela, Cardini, Ulisse, Carotenuto, Ylenia, Checcucci, Giovanni, Chiusano, Maria Luisa, D’Ambra, Isabella, d’Ippolito, Giuliana, Di Capua, Iole, Donnarumma, Vincenzo, Fontana, Angelo, Furia, Marta, Galarza-Verkovitch, Denisse, Gallia, Roberto, Labadie, Karine, Leone, Serena, Licandro, Priscilla, Longo, Antonio, Maselli, Maira, Merquiol, Louise, Murano, Carola, Oliveira, Pedro H., Passarelli, Augusto, Percopo, Isabella, Perdereau, Aude, Piredda, Roberta, Raffini, Francesca, Roncalli, Vittoria, Ruscheweyh, Hans-Joachim, Russo, Ennio, Saggiomo, Maria, Santinelli, Chiara, Sarno, Diana, Sunagawa, Shinichi, Tramontano, Ferdinando, Trano, Anna Chiara, Uttieri, Marco, Wincker, Patrick, Zampicinini, Gianpaolo, Casotti, Raffaella, Conversano, Fabio, D’Alelio, Domenico, Iudicone, Daniele, Margiotta, Francesca, and Montresor, Marina

Published
2024
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5. Evolution of the ribbon-like organization of the Golgi apparatus in animal cells

Author

Benvenuto,Giovanna, Leone, Serena, Astoricchio, Emanuele, Bormke, Sophia, Jasek, Sanja, D’Aniello, Enrico, Kittelmann, Maike, McDonald, Kent, Hartenstein, Volker, Baena, Valentina, Escrivà, Héctor, Bertrand, Stephanie, Schierwater, Bernd, Burkhardt, Pawel, Ruiz-Trillo, Iñaki, Jékely, Gáspár, Ullrich-Luter, Jack, Luter, Carsten, D’Aniello, Salvatore, Arnone, Maria Ina, Ferraro, Francesco, Benvenuto,Giovanna, Leone, Serena, Astoricchio, Emanuele, Bormke, Sophia, Jasek, Sanja, D’Aniello, Enrico, Kittelmann, Maike, McDonald, Kent, Hartenstein, Volker, Baena, Valentina, Escrivà, Héctor, Bertrand, Stephanie, Schierwater, Bernd, Burkhardt, Pawel, Ruiz-Trillo, Iñaki, Jékely, Gáspár, Ullrich-Luter, Jack, Luter, Carsten, D’Aniello, Salvatore, Arnone, Maria Ina, and Ferraro, Francesco

Abstract

The ‘‘ribbon,’’ a structural arrangement in which Golgi stacks connect to each other, is considered to be restricted to vertebrate cells. Although ribbon disruption is linked to various human pathologies, its functional role in cellular processes remains unclear. In this study, we investigate the evolutionary origin of the Golgi ribbon. We observe a ribbon-like architecture in the cells of several metazoan taxa suggesting its early emergence in animal evolution predating the appearance of vertebrates. Supported by AlphaFold2 modeling, we propose that the evolution of Golgi reassembly and stacking protein (GRASP) binding by golgin tethers may have driven the joining of Golgi stacks resulting in the ribbon-like configuration. Additionally, we find that Golgi ribbon assembly is a shared developmental feature of deuterostomes, implying a role in embryogenesis. Overall, our study points to the functional significance of the Golgi ribbon beyond vertebrates and underscores the need for further investigations to unravel its elusive biological roles.

Published
2024

7. Evolution of the ribbon-like organization of the Golgi apparatus in animal cells

Author

Benvenuto, Giovanna, primary, Leone, Serena, additional, Astoricchio, Emanuele, additional, Bormke, Sophia, additional, Jasek, Sanja, additional, D’Aniello, Enrico, additional, Kittelmann, Maike, additional, McDonald, Kent, additional, Hartenstein, Volker, additional, Baena, Valentina, additional, Escrivà, Héctor, additional, Bertrand, Stephanie, additional, Schierwater, Bernd, additional, Burkhardt, Pawel, additional, Ruiz-Trillo, Iñaki, additional, Jékely, Gáspár, additional, Ullrich-Lüter, Jack, additional, Lüter, Carsten, additional, D’Aniello, Salvatore, additional, Arnone, Maria Ina, additional, and Ferraro, Francesco, additional

Published
2024
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14. Oxidoreductases and metal cofactors in the functioning of the earth

Author

Hay Mele, Bruno, additional, Monticelli, Maria, additional, Leone, Serena, additional, Bastoni, Deborah, additional, Barosa, Bernardo, additional, Cascone, Martina, additional, Migliaccio, Flavia, additional, Montemagno, Francesco, additional, Ricciardelli, Annarita, additional, Tonietti, Luca, additional, Rotundi, Alessandra, additional, Cordone, Angelina, additional, and Giovannelli, Donato, additional

Published
2023
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17. Oxidoreductases and metal cofactors in the functioning of Earth

Author

Hay Mele, Bruno, primary, Monticelli, Maria, additional, Leone, Serena, additional, Bastoni, Deborah, additional, Barosa, Bernardo, additional, Cascone, Martina, additional, Migliaccio, Flavia, additional, Montemagno, Francesco, additional, Ricciardelli, Annarita, additional, Tonietti, Luca, additional, Rotundi, Alessandra, additional, Cordone, Angelina, additional, and Giovannelli, Donato, additional

Published
2023
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20. Evolution of the ribbon-like organization of the Golgi apparatus in animal cells

Author

Benvenuto, Giovanna, primary, Leone, Serena, additional, Astoricchio, Emanuele, additional, Bormke, Sophia, additional, Jasek, Sanja, additional, D’Aniello, Enrico, additional, Kittelmann, Maike, additional, McDonald, Kent, additional, Hartenstein, Volker, additional, Baena, Valentina, additional, Escrivà, Héctor, additional, Bertrand, Stephanie, additional, Schierwater, Bernd, additional, Burkhardt, Pawel, additional, Ruiz-Trillo, Iñaki, additional, Jékely, Gáspár, additional, Ullrich-Lüter, Jack, additional, Lüter, Carsten, additional, D’Aniello, Salvatore, additional, Arnone, Maria Ina, additional, and Ferraro, Francesco, additional

Published
2023
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24. Toxicological Impacts of Microplastics: Effects on Levels of Cellular Thiols in Mytilus galloprovincialis.

Author

Murano, Carola, Palumbo, Anna, and Leone, Serena

Subjects
PLASTIC marine debris, MYTILUS galloprovincialis, MICROPLASTICS, BIOCOMPLEXITY, OXIDIZING agents, OXIDATIVE stress, THIOLS
Abstract

Over the last decade, the biological impact of microplastics in marine environments has become a serious global concern. Beyond their biological complexity, it is believed that many lethal and sublethal effects related to microplastic toxicity are triggered by oxidative stress and subsequently activated pathways. Thus, for marine organisms, having efficient mechanisms to fight the accumulation of oxidizing agents becomes indispensable to counteract the effects of microplastics. To date, our knowledge of the physiological effects of microplastics and the response of the antioxidant system in benthic species remains limited. The purpose of our study was to investigate the effects of short‐term exposure on the levels of two fundamental nonprotein antioxidants, glutathione (GSH) and ovothiol (OSH), in different tissues of Mytilus galloprovincialis. Our results show that the metabolism of OSH and GSH in mussels is clearly affected by acute microplastic exposure, and that the antioxidant response differs based on sex and reproductive stage. Indeed, although in the reproductive season the overall levels of GSH and OSH in different tissues significantly increase with respect to the control condition, the antioxidant response of the organisms, especially males, in the spent stage often exhibits a biphasic U‐shaped dose–response effect. Our study represents a pivotal investigation on the effects of microplastic exposure on the pools of two fundamental cellular antioxidants, with potential ecodiagnostic implications to forecast the stress status after exposure to microplastics, and highlights the possibility that the effects of these contaminants may vary over time based on the physiological condition of the animals. Environ Toxicol Chem 2023;42:1607–1613. © 2023 SETAC [ABSTRACT FROM AUTHOR]

Published
2023
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27. Cost analysis of extended half-life recombinant factor IX products in the treatment of haemophilia B in Italy: an update

Author

Aiello, Andrea, Mancuso, Maria E., Leone, Serena, Rossi, Letizia, Cioni, Lorenzo, Teruzzi, Cristina, Aiello, Andrea, Mancuso, Maria E., Leone, Serena, Rossi, Letizia, Cioni, Lorenzo, and Teruzzi, Cristina

Abstract

Haemophilia B (HB) is a rare disease which may lead to chronic disabling arthropathy, resulting in a significant clinical, social and economic impact. In recent years, new extended half-life (EHL) factor IX concentrates produced by recombinant technology (rFIX) have been developed. They have shown significantly prolonged half-life as compared to other rFIX products and improved bleeding control when used as prophylaxis. To date, EHL rFIX products reimbursed in Italy are a recombinant coagulation factor IX produced with Fc technology (rFIXFc) and a recombinant fusion protein containing rFIX fused with recombinant albumin (rIX-FP). The results of extension studies with injection intervals with a median of almost every 14 days for the complete individualized interval prophylaxis (IP) group on rFIXFc and 21 days for a selected subgroup of patients on rIX-FP have recently been published.The aim of this analysis was to estimate the cost of prophylactic treatment with rFIXFc and rIX-FP in adult patients, in the light of new clinical evidence and current average prices in Italy.The cost of therapy was estimated on the basis of the results of extension studies, the average prices reported in regional drug tenders and assuming an average patient weight of 70 kg.The analysis estimated a cost per patient/year between €224,407 and €230,355 for rFIXFc and between €242,259 and €368,587 for rIX-FP. The sensitivity analysis confirmed the robustness of the results.The use of rFIXFc over rIX-FP proves to be the least expensive choice for the treatment of HB in Italy.

Published
2022

30. Detailed characterization of the lipid A fraction from the nonpathogen Acinetobacter radioresistens strain S13

Author

Leone Serena, Sturiale Luisa, Pessione Enrica, Mazzoli Roberto, Giunta Carlo, Lanzetta Rosa, Garozzo Domenico, Molinaro Antonio, and Parrilli Michelangelo

Subjects
lipopolysaccharide, matrix-assisted laser-desorption ionization mass spectrometry, fatty acid, Biochemistry, QD415-436
Abstract

The genus Acinetobacter is composed of ubiquitous, generally nonpathogen environmental bacteria. Interest concerning these microorganisms has increased during the last 30 years, because some strains, belonging to the so-called A. baumannii-A. calcoaceticus complex, have been implicated in some severe pathological states in debilitated and hospitalized patients. The involvement of lipopolysaccharides (LPSs) as virulence factors in infections by Acinetobacter has been proven, and ongoing studies are aimed toward the complete serological characterization of the O-polysaccharides from LPSs isolated in clinical samples. Conversely, no characterization of the lipid A fraction from Acinetobacter strains has been performed. Here, the detailed structure of the lipid A fraction from A. radioresistens S13 is reported for the first time. A. radioresistens strains have never been isolated in cases of infectious disease. Nevertheless, it is known that the lipid A structure, with minor variations, is highly conserved across the genus; thus, structural details acquired from studies of this nonpathogen strain represent a useful basis for further studies of pathogen species.

Published
2007
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40. Disordered Peptides Looking for Their Native Environment: Structural Basis of CB1 Endocannabinoid Receptor Binding to Pepcans

Author

Emendato, Alessandro, Guerrini, Remo, Marzola, Erika, Wienk, Hans, Boelens, Rolf, Leone, Serena, Picone, Delia, Sub NMR Spectroscopy, NMR Spectroscopy, Emendato, Alessandro, Guerrini, Remo, Marzola, Erika, Wienk, Han, Boelens, Rolf, Leone, Serena, Picone, Delia, Sub NMR Spectroscopy, and NMR Spectroscopy

Subjects
0301 basic medicine, Allosteric modulator, Cannabinoid receptor, CB1 endocannabinoid receptor, Endocannabinoid system, Hemopressin, Intrinsically unfolded peptides, Pepcans, Structure-activity relationships, Allosteric regulation, Peptide, Biochemistry, Biochemistry, Genetics and Molecular Biology (miscellaneous), NO, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Molecular Biosciences, Receptor, lcsh:QH301-705.5, Molecular Biology, intrinsically unfolded peptides, Original Research, chemistry.chemical_classification, Pepcan, hemopressin, structure-activity relationships, Biological activity, pepcans, Structure-activity relationship, 3. Good health, 030104 developmental biology, lcsh:Biology (General), chemistry, Biophysics, lipids (amino acids, peptides, and proteins), Intrinsically unfolded peptide, 030217 neurology & neurosurgery
Abstract

Endocannabinoid peptides, or "pepcans," are endogenous ligands of the CB1 cannabinoid receptor. Depending on their length, they display diverse activity: For instance, the nona-peptide Pepcan-9, also known as hemopressin, is a powerful inhibitor of CB1, whereas the longer variant Pepcan-12, which extends by only three amino acid residues at the N-terminus, acts on both CB1 and CB2 as an allosteric modulator, although with diverse effects. Despite active research on their pharmacological applications, very little is known about structure-activity relationships of pepcans. Different structures have been proposed for the nona-peptide, which has also been reported to form fibrillar aggregates. This might have affected the outcome and reproducibility of bioactivity studies. In an attempt of elucidating the determinants of both biological activity and aggregation propensity of Pepcan-9 and Pepcan-12, we have performed their structure characterization in solvent systems characterized by different polarity and pH. We have found that, while disordered in aqueous environment, both peptides display helical structure in less polar environment, mimicking the proteic receptor milieu. In the case of Pepcan-9, this structure is fully consistent with the observed modulation of the CB1. For Pepcan-12, whose allosteric binding site is still unknown, the presented structure is compatible with the binding at one of the previously proposed allosteric sites on CB1. These findings open the way to structure-driven design of selective peptide modulators of CB1.

Published
2018
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