85 results on '"Leonce, Stéphane"'
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2. Characterization of novel Checkpoint kinase 1 inhibitors by in vitro assays and in human cancer cells treated with topoisomerase inhibitors
3. Synthesis and cytotoxic activity of benzo[ a]acronycine and benzo[ b]acronycine substituted on the A ring
4. Synthesis and cytotoxic activity of psorospermin and acronycine analogues in the 3-propyloxy-acridin-9(10H)-one and -benzo[b]acridin-12(5H)-one series
5. An unusual DNA binding compound, S23906, induces mitotic catastrophe in cultured human cells
6. Synthesis, biological evaluation and docking studies of 4-amino-tetrahydroquinazolino[3,2- e]purine derivatives
7. Synthesis, cytotoxic activity, and DNA binding properties of antitumor cis-1,2-dihydroxy-1,2-dihydrobenzo[ b]acronycine cinnamoyl esters
8. Benzopyridooxathiazepine derivatives as novel potent antimitotic agents
9. Novel 5-azaindolocarbazoles as cytotoxic agents and Chk1 inhibitors
10. Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles
11. Structure–activity relationships in the acronycine and benzo[ b]acronycine series: Role of the pyran ring
12. Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4- a]carbazole-1,3-diones, pyrrolo[3,4- c]carbazole-1,3-diones, and 2-aminopyridazino[3,4- a]pyrrolo[3,4- c]carbazole-1,3,4,7-tetraone
13. Cytotoxic turrianes of Kermadecia elliptica from the New Caledonian rainforest
14. Synthesis and biological activities of isogranulatimide analogues
15. Cellular knock-down of quinone reductase 2: A laborious road to successful inhibition by RNA interference
16. Bis-imide granulatimide analogues as potent Checkpoint 1 kinase inhibitors
17. Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring
18. Synthesis and biological evaluation of new dipyrrolo[3,4- a:3,4- c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions
19. Synthesis and biological activity of 6 H-isoindolo[2,1- a]indol-6-ones, analogues of batracylin, and related compounds
20. Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of dipyrrolo[3,4- a:3,4- c]carbazole-triones
21. Cytotoxic and antitumoral properties in a series of new, ring D modified, olivacine analogues
22. Synthesis and cytotoxicities of 7-aza rebeccamycin analogues bearing various substituents on the sugar moiety, on the imide nitrogen and on the carbazole framework
23. A transesterification reaction is implicated in the covalent binding of benzo[b]acronycine anticancer agents with DNA and glutathion
24. Synthesis and cytotoxic activity of benzo[ c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine
25. Analogues of antifungal tjipanazoles from rebeccamycin
26. Novel antitumor indenoindole derivatives targeting DNA and topoisomerase II
27. Covalent binding to glutathione of the DNA-alkylating antitumor agent, S23906-1
28. Synthesis and cytotoxicity of dihydroartemisinin ethers containing cyanoarylmethyl group
29. Syntheses and antiproliferative activities of rebeccamycin analogues bearing two 7-azaindole moieties
30. MYCN Enhances P-gp/ MDR1 Gene Expression in the Human Metastatic Neuroblastoma IGR-N-91 Model
31. Induction of apoptosis in HL-60 leukemia and B16 melanoma cells by the acronycine derivative S23906-1
32. Synthesis, cytotoxic activity, NMR study and stereochemical effects of some new pyrano[3,2-b]thioxanthen-6-ones and Pyrano[2,3-c]thioxanthen-7-ones
33. Rebeccamycin analogues from Indolo[2,3-c]carbazole
34. Cytotoxic activities of novel hexahydroindolizino[8,7-b]indole derivatives prepared by 1,3-dipolar cycloaddition reactions of 3,4-dihydro-β-carboline ylides
35. Synthesis and biological activities of indolocarbazoles bearing amino acid residues
36. Synthesis and cytotoxicity of artemisinin derivatives containing cyanoarylmethyl group
37. First synthesis and pharmacological evaluation of benzoindolizidine and benzoquinolizidine analogues of α- and β-peltatin
38. Effects of Ceramide on Apoptosis, Proteoglycan Degradation, and Matrix Metalloproteinase Expression in Rabbit Articular Cartilage
39. Synthesis of Pyrido[2,3- b]indole Derivatives via Diels–Alder Reactions of 2- and 3-Vinylpyrrolo[2,3- b]pyridines
40. Synthesis and cytotoxic activity of 2-dialkylaminoethylamino substituted xanthenone and thioxanthenone derivatives
41. Synthesis and in vitro antitumour evaluation of benzothiazole-2-carbonitrile derivatives
42. Tröger’s bases in the acronycine, benzo[a]acronycine, and benzo[b]acronycine series
43. Synthèse d'inhibiteurs de la Chk1, analogues de la granulatimide et de l'isogranulatimide, , 27 août – 1er septembre 2006
44. Synthesis and biological evaluation of novel benzodioxinocarbazoles (BDCZs) as potential anticancer agents
45. Synthèse d'analogues de la granulatimide possédant un maléimide à la place de l'hétérocycle imidazole
46. Analogues of tjipanazoles from rebeccamycin: synthesis, in vitro antiproliferative activities, and inhibitory properties toward topoisomerase I
47. A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor
48. Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of indolylpyrazolones and indolylpyridazinedione
49. MYCN Enhances P-gp/MDR1 Gene Expression in the Human Metastatic Neuroblastoma IGR-N-91 Model
50. Synthesis and Cytotoxic Activity of pyridazino[1′,6′:1,2]pyrido[3,4-b]indol-5-inium derivatives as anti-cancer agents
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