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10 results on '"Leonard Ganz"'

1. A Dual-Chamber Leadless Pacemaker

Author

Reinoud E. Knops, Vivek Y. Reddy, James E. Ip, Rahul Doshi, Derek V. Exner, Pascal Defaye, Robert Canby, Maria Grazia Bongiorni, Morio Shoda, Gerhard Hindricks, Petr Neužil, Mayer Rashtian, Karel T.N. Breeman, Jordan R. Nevo, Leonard Ganz, Chris Hubbard, and Daniel J. Cantillon

Subjects
General Medicine
Published
2023

2. LB-456640-1 PERCUTANEOUS IMPLANTATION OF A DUAL CHAMBER LEADLESS CARDIAC PACEMAKER SYSTEM WITH BIDIRECTIONAL COMMUNICATION FOR ATRIOVENTRICULAR SYNCHRONY

Author

Daniel J. Cantillon, Vivek Y. Reddy, James E. Ip, Rahul N. Doshi, Derek V. Exner, Pascal Defaye, Robert C. Canby, Maria Grazia Bongiorni, Morio Shoda, Gerhard Hindricks, Petr Neuzil, Mayer Rashtian, Karel Breeman, Jordan Nevo, Leonard Ganz, Chris Hubbard, and Reinoud Knops

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Published
2023

3. Electrical storm

Author

Leonard Ganz

Subjects
cardiovascular system, cardiovascular diseases
Abstract

Electrical storm is a condition in which there are recurrent episodes of ventricular fibrillation or sustained and/or poorly tolerated ventricular tachycardia that occurs within a short period and requires aggressive intervention to prevent imminent mortality and other adverse outcomes. The condition may be related to precipitating factors, such as ischaemia or electrolyte disturbances, or may be part of an underlying cardiac disorder (e.g. cardiomyopathy, ischaemic heart disease, and channelopathies) that, often for uncertain reasons, culminates in recurrent episodes of life-threatening ventricular arrhythmias. Frequently, sympathetic activation plays a role in precipitating episodes. Here, electrical storm is characterized and an approach to management is discussed.

Published
2018

4. Simultaneous Atrial and Ventricular Anti-Tachycardia Pacing as a Novel Method of Rhythm Discrimination

Author

Ogundu Ngwu, B S Jill Christensen, William Barrington, Samir Saba, Linda C. Baker, Sandeep Jain, M. Brown, and Leonard Ganz

Subjects
Male, Tachycardia, medicine.medical_specialty, Time Factors, Heart Ventricles, Large population, Rhythm, Physiology (medical), Internal medicine, Tachycardia, Supraventricular, medicine, Humans, In patient, Heart Atria, cardiovascular diseases, Cycle length, Proarrhythmia, Ejection fraction, business.industry, Cardiac Pacing, Artificial, Atrial fibrillation, Middle Aged, medicine.disease, Defibrillators, Implantable, Tachycardia, Ventricular, Cardiology, Female, Medical emergency, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract

Dual-Chamber ATP for Rhythm Discrimination. Background: Inappropriate shocks remain a problem in patients with defibrillators (ICD). Objective: To evaluate a new discrimination algorithm for supraventricular (SVT) and ventricular (VT) tachycardias, based on the response to simultaneous (A+V) atrial (A) and ventricular (V) anti-tachycardia pacing (ATP). Methods: Patients undergoing electrophysiological testing or dual-chamber implantable cardioverter-defibrillator (ICD) implantation were enrolled (N = 32) and underwent A+V ATP through a Marquis ICD with investigational software. If persisting after ATP, the rhythm was classified as VT if the first electrical event was sensed on the V channel and as an SVT otherwise. Results: Arrhythmia sequences (N = 275; 53 VT; 222 SVT) were analyzed in 26 patients (age = 51 ± 17 years, 13 men, LVEF = 0.49 ± 0.14). In response to A+V ATP, 55% of SVT versus 41% of VT episodes were terminated (P = NS). Termination of VT but not of SVT was more likely with faster (50% at ATP/arrhythmia cycle length (CL) = 0.81 vs 8% at ATP/arrhythmia CL = 0.88, P = 0.02) but not with longer ATP bursts (P = NS). Of the 115 arrhythmias that persisted after A+V ATP, the algorithm correctly classified 24 of 24 VT (GEE-adjusted sensitivity = 100%) and 85 of 91 SVT (GEE-adjusted specificity = 93%). Proarrhythmia was noted after two A+V ATP, in the form of atrial fibrillation induction and VT acceleration. Conclusions: We describe a new algorithm that can discriminate between SVT and VT with a high sensitivity and specificity. This form of ATP can terminate 55% of SVT sequences. The performance of this new algorithm merits further testing in a large population of dual-chamber ICD patients.

Published
2006

5. Mechanisms of Ventricular Tachycardia Induction

Author

Leonard Ganz

Subjects
Tachycardia, medicine.medical_specialty, business.industry, MEDLINE, Ventricular tachycardia, medicine.disease, Physiology (medical), Internal medicine, Cardiology, medicine, Dobutamine, medicine.symptom, Cardiology and Cardiovascular Medicine, business, medicine.drug
Published
2004

7. Contributors

Author

Charles S. Abrams, Frank J. Accurso, Nezam H. Afdhal, Cem Akin, Allen J. Aksamit, Qais Al-Awqati, Ban Mishu Allos, David Altshuler, Michael J. Aminoff, Jeffrey L. Anderson, Karl E. Anderson, Larry J. Anderson, Karen H. Antman, Aśok C. Antony, Gerald B. Appel, Frederick R. Appelbaum, William P. Arend, Paul Arguin, James O. Armitage, Cheryl A. Armstrong, M. Amin Arnaout, Robert Arnold, David Atkins, William L. Atkinson, Dennis Ausiello, Bruce R. Bacon, Grover C. Bagby, Barbara J. Bain, Dean F. Bajorin, Mark Ballow, Robert W. Baloh, Jonathan Barasch, Richard L. Barbano, Murray G. Baron, Elizabeth Barrett-Connor, Michael J. Barry, Bruce A. Barshop, John G. Bartlett, Mary Barton, Robert C. Basner, Stephen G. Baum, Daniel G. Bausch, Arnold S. Bayer, Hasan Bazari, John H. Beigel, George A. Beller, Robert M. Bennett, Joseph R. Berger, Paul Berk, Nancy Berliner, James L. Bernat, Philip J. Bierman, Bruce R. Bistrian, Joseph J. Biundo, Charles D. Blanke, Joel N. Blankson, Martin J. Blaser, William A. Blattner, Thomas P. Bleck, William E. Boden, C. Richard Boland, Jean Bolognia, Robert Bonomo, Larry Borish, Patrick J. Bosque, Randall Brand, Itzhak Brook, Enrico Brunetti, David M. Buchner, Pierre A. Buffet, H. Franklin Bunn, Peter A. Calabresi, David P. Calfee, Hugh Calkins, Douglas Cameron, Michael Camilleri, Grant W. Cannon, Maria Domenica Cappellini, Blase A. Carabello, Edgar M. Carvalho, Agustin Castellanos, Naga P. Chalasani, Henry Chambers, Mary Charlson, William P. Cheshire, Patrick F. Chinnery, David C. Christiani, David R. Clemmons, Jeffrey Cohen, Myron S. Cohen, Steven P. Cohen, Steven L. Cohn, Robert Colebunders, Joseph M. Connors, Deborah J. Cook, C. Ralph Corey, Kenneth H. Cowan, William A. Craig, Simon L. Croft, Mary K. Crow, John A. Crump, Mark R. Cullen, Gary C. Curhan, Inger K. Damon, Troy E. Daniels, Nancy Davidson, Lisa M. DeAngelis, Malcolm M. DeCamp, Carlos Del Rio, George D. Demetri, Robert H. Demling, Patricia A. Deuster, Robert B. Diasio, David J. Diemert, Kathleen B. Digre, John M. Douglas, Jeffrey M. Drazen, Stephen C. Dreskin, W. Lawrence Drew, George L. Drusano, Thomas D. DuBose, F. Daniel Duffy, Herbert L. DuPont, Madeleine Duvic, Kathryn M. Edwards, N. Lawrence Edwards, Lawrence H. Einhorn, Ronald J. Elin, George M. Eliopoulos, Perry Elliott, Jerrold J. Ellner, Louis J. Elsas, Dirk M. Elston, Ezekiel J. Emanuel, Gregory F. Erickson, Armin Ernst, Joel D. Ernst, David S. Ettinger, Amelia Evoli, Douglas O. Faigel, Gary W. Falk, Murray J. Favus, Gene Feder, Stephan D. Fihn, Gary S. Firestein, Neil Fishman, Lee A. Fleisher, Marsha D. Ford, Chris E. Forsmark, Vance G. Fowler, Jay W. Fox, Manuel A. Franco, Martyn A. French, Karen Freund, Linda P. Fried, Cem Gabay, Kenneth L. Gage, Robert F. Gagel, John N. Galgiani, Patrick G. Gallagher, Eithan Galun, Leonard Ganz, Guadalupe Garcia-Tsao, Jonathan D. Gates, William M. Geisler, Tony P. George, Dale N. Gerding, M. Eric Gershwin, Morie A. Gertz, Gordon D. Ginder, Jeffrey Ginsberg, Geoffrey S. Ginsburg, Michael Glogauer, John W. Gnann, Matthew R. Golden, Lee Goldman, Ellie J. Goldstein, Lawrence T. Goodnough, Jörg J. Goronzy, Eduardo Gotuzzo, Deborah Grady, Leslie C. Grammer, F. Anthony Greco, Harry B. Greenberg, Peter K. Gregersen, Robert C. Griggs, Lisa M. Guay-Woodford, Richard L. Guerrant, Colleen Hadigan, John D. Hainsworth, Anders Hamsten, Kenneth R. Hande, H. Hunter Handsfield, Göran K. Hansson, Rashidul Haque, Raymond C. Harris, Stephen Crane Hauser, Frederick G. Hayden, Letha Healey, Douglas C. Heimburger, Erik L. Hewlett, David R. Hill, Nicholas S. Hill, L. David Hillis, Jack Hirsh, V. Michael Holers, Steven M. Holland, Steven Hollenberg, Edward W. Hook, Laurence Huang, Leonard D. Hudson, Steven E. Hyman, Michael Iannuzzi, Robert D. Inman, Sharon K. Inouye, Karl L. Insogna, Silvio E. Inzucchi, Eric M. Isselbacher, Ahmedin Jemal, Joanna Jen, Dennis M. Jensen, Michael D. Jensen, Robert T. Jensen, Mariell Jessup, Stuart Johnson, Ralph F. Józefowicz, Stephen G. Kaler, Moses R. Kamya, Hagop Kantarjian, David R. Karp, Daniel L. Kastner, David A. Katzka, Debra K. Katzman, Carol A. Kauffman, Kenneth Kaushansky, Emmet B. Keeffe, Morton Kern, Gerald T. Keusch, David H. Kim, Matthew Kim, Louis V. Kirchhoff, Michael J. Klag, Samuel Klein, David S. Knopman, Tamsin A. Knox, Albert I. Ko, Rami S. Komrokji, Dimitrios P. Kontoyiannis, Barbara S. Koppel, Kevin Korenblat, Bruce R. Korf, Neil J. Korman, Joseph A. Kovacs, Monica Kraft, Christopher M. Kramer, Donna M. Krasnewich, Peter J. Krause, Henry M. Kronenberg, Ernst J. Kuipers, Paul Ladenson, Donald W. Landry, Nancy E. Lane, Anthony E. Lang, Richard A. Lange, George V. Lawry, Thomas H. Lee, William M. Lee, James Leggett, Adam Lerner, Stuart Levin, Stephanie M. Levine, Gary R. Lichtenstein, Henry W. Lim, Aldo A.M. Lima, Andrew H. Limper, Geoffrey S.F. Ling, Alan F. List, William C. Little, Richard F. Loeser, Bennett Lorber, Donald E. Low, Daniel R. Lucey, James R. Lupski, Henry T. Lynch, Jeffrey M. Lyness, Bruce W. Lytle, C. Ronald MacKenzie, Harriet MacMillan, Robert D. Madoff, Mark W. Mahowald, Atul Malhotra, Lionel A. Mandell, Peter Manu, Marsha D. Marcus, Ariane J. Marelli, Maurie Markman, Andrew R. Marks, Kieren A. Marr, Thomas J. Marrie, Paul Martin, Joel B. Mason, Barry M. Massie, Henry Masur, Eric L. Matteson, Toby Maurer, Emeran A. Mayer, Stephen A. McClave, F. Dennis McCool, Charles E. McCulloch, Michael A. McGuigan, John McHutchison, William McKenna, Vallerie McLaughlin, John J.V. McMurray, Mary McNaughton-Collins, Kenneth McQuaid, Frederick W. Miller, Kenneth L. Minaker, Jonathan W. Mink, Daniel R. Mishell, William E. Mitch, Mark E. Molitch, Bruce A. Molitoris, José G. Montoya, Fred Morady, Jeffrey A. Moscow, Andrew H. Murr, Robert J. Myerburg, Stanley Naguwa, Stanley J. Naides, Theodore E. Nash, Avindra Nath, Eric G. Neilson, Lawrence S. Neinstein, Thomas B. Newman, William L. Nichols, Lynnette K. Nieman, Dennis E. Niewoehner, S. Ragnar Norrby, David A. Norris, Susan O’Brien, Francis G. O’Connor, Patrick G. O’Connor, James R. O'Dell, Anne E. O'Donnell, Jae K. Oh, Jeffrey E. Olgin, Jeffrey W. Olin, Walter A. Orenstein, Douglas R. Osmon, Catherine M. Otto, Stephen A. Paget, Mark Papania, Peter G. Pappas, Pankaj Jay Pasricha, David L. Paterson, Carlo Patrono, Jean-Michel Pawlotsky, Richard D. Pearson, Eli N. Perencevich, Trish M. Perl, Michael C. Perry, William A. Petri, Marc A. Pfeffer, Perry J. Pickhardt, Gerald B. Pier, David S. Pisetsky, Marshall R. Posner, Charlene Prather, Basil A. Pruitt, Reed E. Pyeritz, Thomas C. Quinn, Jai Radhakrishnan, Ganesh Raghu, Margaret V. Ragni, Srinivasa N. Raja, S. Vincent Rajkumar, Didier Raoult, Robert W. Rebar, Annette C. Reboli, K. Rajender Reddy, Donald A. Redelmeier, Susan E. Reef, Neil M. Resnick, David B. Reuben, Herbert Y. Reynolds, Emanuel P. Rivers, Robert A. Rizza, Lewis R. Roberts, Jean-Marc Rolain, José R. Romero, G. David Roodman, Clifford Rosen, Karen Rosene-Montella, Philip J. Rosenthal, Marc E. Rothenberg, Hope S. Rugo, James A. Russell, Anil K. Rustgi, Robert A. Salata, Jane E. Salmon, Renato M. Santos, Michael N. Sawka, Andrew I. Schafer, William Schaffner, W. Michael Scheld, Eileen Schneider, Thomas J. Schnitzer, Robert T. Schooley, David L. Schriger, Steven A. Schroeder, Lynn M. Schuchter, Sam Schulman, Lawrence B. Schwartz, Robert S. Schwartz, Carlos Seas, Steven A. Seifert, Julian L. Seifter, Clay F. Semenkovich, Carol E. Semrad, F. John Service, George M. Shaw, Pamela J. Shaw, Robert S. Sherwin, Michael E. Shy, Wilmer L. Sibbitt, Ellen Sidransky, Robert F. Siliciano, Michael S. Simberkoff, David L. Simel, Karl Skorecki, Arthur S. Slutsky, Eric J. Small, Gerald W. Smetana, Frederick S. Southwick, Robert F. Spiera, Stanley M. Spinola, Pawel Stankiewicz, Paul Stark, Lynne S. Steinbach, Martin H. Steinberg, Theodore S. Steiner, David S. Stephens, David A. Stevens, William G. Stevenson, Arthur E. Stillman, James K. Stoller, John H. Stone, Edwin P. Su, Roland W. Sutter, Morton N. Swartz, Ronald S. Swerdloff, Megan Sykes, Thomas A. Tami, Susan M. Tarlo, Victoria M. Taylor, Ayalew Tefferi, Paul S. Teirstein, Sam R. Telford, Margaret Tempero, Michael J. Thun, Nina Tolkoff-Rubin, Antonella Tosti, John J. Treanor, Ronald B. Turner, Arthur C. Upton, Greet Van den Berghe, John Varga, Adrian Vella, Joseph G. Verbalis, Ronald G. Victor, Angela Vincent, Paul A. Volberding, Julie M. Vose, Robert M. Wachter, Edward H. Wagner, Edward E. Walsh, Thomas J. Walsh, Christina Wang, Christine Wanke, Stephen I. Wasserman, Heiner Wedemeyer, Geoffrey A. Weinberg, David A. Weinstein, Robert S. Weinstein, Roger D. Weiss, Martin Weisse, Jeffrey I. Weitz, Samuel A. Wells, Richard P. Wenzel, Victoria P. Werth, Sterling G. West, Cornelia M. Weyand, A. Clinton White, Christopher J. White, Perrin C. White, Richard J. Whitley, Michael P. Whyte, Samuel Wiebe, Jeanine P. Wiener-Kronish, Jennifer E. Wildes, Alexander Wilmer, William Winkenwerder, Joseph I. Wolfsdorf, Gary P. Wormser, John J. Wysolmerski, Myron Yanoff, Neal S. Young, William F. Young, Alan S.L. Yu, Mark L. Zeidel, Peter Zimetbaum, and Justin A. Zivin

Published
2012

8. Implantable cardioverter-defibrillators for secondary prevention: is it worth it in the elderly?

Author

Leonard Ganz and Darren Traub

Subjects
medicine.medical_specialty, Population, Ventricular Dysfunction, Left, medicine, Overall survival, Humans, Pharmacologic therapy, Intensive care medicine, education, Aged, Randomized Controlled Trials as Topic, Secondary prevention, education.field_of_study, business.industry, Health Policy, Patient Selection, Age Factors, Arrhythmias, Cardiac, Icd therapy, United States, Defibrillators, Implantable, Patient population, Death, Sudden, Cardiac, Physical therapy, Implant, Geriatrics and Gerontology, Cardiology and Cardiovascular Medicine, business, Gerontology, Anti-Arrhythmia Agents, Cardiac deaths
Abstract

Aging is associated with structural alterations in the heart that predispose the elderly to life-threatening ventricular arrhythmias. The majority of sudden cardiac deaths occur in people aged 65 and older. As the proportion of elderly in our population continues to grow, a greater number of elderly patients with malignant ventricular arrhythmias will require appropriate medical management. Clinical outcome trials have demonstrated that implantable cardioverter-defibrillators (ICDs) improve overall survival compared with pharmacologic therapy when used for the secondary prevention of cardiac arrest. Despite proven efficacy, physicians may be reluctant to implant a defibrillator in an older patient. This review summarizes the data pertaining to the use of defibrillators for secondary prevention in the elderly. ICD use for secondary prevention reduces all-cause mortality and appears to be economically advantageous in an older patient population. Currently, there is no convincing data to suggest that ICD therapy should be withheld from a patient based on age alone.

Published
2006

9. Autonomic blockade unmasks maturational differences in rate-dependent atrioventricular nodal conduction and facilitation in the mouse

Author

Samir, Saba, Barry, London, and Leonard, Ganz

Subjects
Male, Aging, Cardiac Pacing, Artificial, Heart, Autonomic Nervous System, Adaptation, Physiological, Synaptic Transmission, Electric Stimulation, Electrocardiography, Mice, Heart Rate, Atrioventricular Node, Animals, Autonomic Nerve Block
Abstract

In large animals, rate-dependent AV nodal (AVN) properties of conduction are modulated by autonomic inputs. In this study, we investigated whether the properties of AVN conduction and facilitation are altered by autonomic blockade in the mouse and whether this effect is age dependent.Young (age 4-6 weeks; n = 11) and adult (age 8-9 months; n = 11) female mice underwent in vivo electrophysiologic testing, before and after autonomic blockade. After autonomic blockade, the adult mice had significantly longer AVN effective refractory period (AVNERP; 67 +/- 14 msec vs 56 +/- 4 msec, P = 0.05) and functional refractory period (AVNFRP; 81 +/- 10 msec vs 72 +/- 4 msec, P = 0.05). With autonomic blockade, the increase from baseline of AVN Wenckebach cycle length (deltaAVW; 1.8 +/- 8.1 msec vs 8.8 +/- 3.3 msec, P = 0.04), as well as of AVNERP (deltaAVNERP; 3.5 +/- 3.5 msec vs 21.4 +/- 12.6 msec, P = 0.002) and AVNFRP (deltaAVNFRP; 2.3 +/- 3.2 msec vs 12.8 +/- 9.0 msec, P = 0.008), was significantly larger in adult than in young mice. Compared with young mice, adult mice were less likely to exhibit AVN facilitation (44% vs 90%, P = 0.03) and had smaller maximal shortening of AVN conduction times after the "test beat" for any coupling of the "facilitating beat" (4 +/- 4 msec vs 7 +/- 3 msec, P = 0.05).Complete autonomic blockade significantly increases AVN conduction times and refractory periods in adult but not in young mice. Adult mice also exhibit less AVN facilitation. Our results confirm that, like in larger animals, rate-dependent murine AVN properties of conduction are under autonomic regulation. Adult mice have higher sympathetic AVN inputs at baseline, leading to slower conduction after autonomic blockade.

Published
2003

10. Transfer of immortality by transfection of genomic DNA from SV40 established cell lines into rat embryo fibroblasts

Author

Leonard Ganz, Jean Feunteun, and Hélène Jacquemin-Sablon

Subjects
Cloned genes, Embryo, Cell Biology, General Medicine, Transfection, Simian virus 40, Biology, Fibroblasts, Embryo, Mammalian, Molecular biology, Phenotype, Rats, Inbred F344, Cell biology, Cell Line, Rats, genomic DNA, Transformation (genetics), Cell culture, DNA, Viral, Animals, Gene, Plasmids
Abstract

The cellular immortalization activity of cloned genes can be identified either in a colony-forming assa of transferred primary rat embryo fibroblasts or in a co-operation assay together with ras. However the demonstration of immortalization activities carried by cellular genes has not been reported. Here we establish that SV40 early genes integrated in genomic DNAs can be stably transferred into rat embryo fibroblasts and selected via their immortalization activity. Attempts to extend this assay to the identification of dominant genes putatively involved in the immortality of several other immortal post-crisis or tumor cells have been unsuccessful suggesting that the immortal phenotype can be brought about through different pathways.

Published
1990

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