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1,986 results on '"Leon I"'

1. Correspondence Between Perceived Pubertal Development and Hormone Levels in 9-10 Year-Olds From the Adolescent Brain Cognitive Development Study

Author

Megan M. Herting, Kristina A. Uban, Marybel Robledo Gonzalez, Fiona C. Baker, Eric C. Kan, Wesley K. Thompson, Douglas A. Granger, Matthew D. Albaugh, Andrey P. Anokhin, Kara S. Bagot, Marie T. Banich, Deanna M. Barch, Arielle Baskin-Sommers, Florence J. Breslin, B. J. Casey, Bader Chaarani, Linda Chang, Duncan B. Clark, Christine C. Cloak, R. Todd Constable, Linda B. Cottler, Rada K. Dagher, Mirella Dapretto, Anthony S. Dick, Nico Dosenbach, Gayathri J. Dowling, Julie A. Dumas, Sarah Edwards, Thomas Ernst, Damien A. Fair, Sarah W. Feldstein-Ewing, Edward G. Freedman, Bernard F. Fuemmeler, Hugh Garavan, Dylan G. Gee, Jay N. Giedd, Paul E. A. Glaser, Aimee Goldstone, Kevin M. Gray, Samuel W. Hawes, Andrew C. Heath, Mary M. Heitzeg, John K. Hewitt, Charles J. Heyser, Elizabeth A. Hoffman, Rebekah S. Huber, Marilyn A. Huestis, Luke W. Hyde, M. Alejandra Infante, Masha Y. Ivanova, Joanna Jacobus, Terry L. Jernigan, Nicole R. Karcher, Angela R. Laird, Kimberly H. LeBlanc, Krista Lisdahl, Monica Luciana, Beatriz Luna, Hermine H. Maes, Andrew T. Marshall, Michael J. Mason, Erin C. McGlade, Amanda S. Morris, Bonnie J. Nagel, Gretchen N. Neigh, Clare E. Palmer, Martin P. Paulus, Alexandra S. Potter, Leon I. Puttler, Nishadi Rajapakse, Kristina Rapuano, Gloria Reeves, Perry F. Renshaw, Claudiu Schirda, Kenneth J. Sher, Chandni Sheth, Paul D. Shilling, Lindsay M. Squeglia, Matthew T. Sutherland, Susan F. Tapert, Rachel L. Tomko, Deborah Yurgelun-Todd, Natasha E. Wade, Susan R. B. Weiss, Robert A. Zucker, and Elizabeth R. Sowell

Subjects
adolescent brain cognitive development, salivary hormones, pubertal development scale, puberty, testosterone, dehydroepiandrosterone, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

AimTo examine individual variability between perceived physical features and hormones of pubertal maturation in 9–10-year-old children as a function of sociodemographic characteristics.MethodsCross-sectional metrics of puberty were utilized from the baseline assessment of the Adolescent Brain Cognitive Development (ABCD) Study—a multi-site sample of 9–10 year-olds (n = 11,875)—and included perceived physical features via the pubertal development scale (PDS) and child salivary hormone levels (dehydroepiandrosterone and testosterone in all, and estradiol in females). Multi-level models examined the relationships among sociodemographic measures, physical features, and hormone levels. A group factor analysis (GFA) was implemented to extract latent variables of pubertal maturation that integrated both measures of perceived physical features and hormone levels.ResultsPDS summary scores indicated more males (70%) than females (31%) were prepubertal. Perceived physical features and hormone levels were significantly associated with child’s weight status and income, such that more mature scores were observed among children that were overweight/obese or from households with low-income. Results from the GFA identified two latent factors that described individual differences in pubertal maturation among both females and males, with factor 1 driven by higher hormone levels, and factor 2 driven by perceived physical maturation. The correspondence between latent factor 1 scores (hormones) and latent factor 2 scores (perceived physical maturation) revealed synchronous and asynchronous relationships between hormones and concomitant physical features in this large young adolescent sample.ConclusionsSociodemographic measures were associated with both objective hormone and self-report physical measures of pubertal maturation in a large, diverse sample of 9–10 year-olds. The latent variables of pubertal maturation described a complex interplay between perceived physical changes and hormone levels that hallmark sexual maturation, which future studies can examine in relation to trajectories of brain maturation, risk/resilience to substance use, and other mental health outcomes.

Published
2021
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2. Benign Fibroepithelial Polyps: A Rare Cause of Ureteropelvic Junction Obstruction in Children

Author

Anitha Ezekiel, Vaidehi Agrawal, Elena Romero, and Leon I. Smith-Harrison

Subjects
Polyps, Pediatric urology, UPJ obstruction, Renal ultrasound, Hydronephrosis, Diseases of the genitourinary system. Urology, RC870-923
Abstract

FEPs are rare, benign mucosal growths that may cause urinary tract obstruction in both adults and children. We present the case of a ten year old Hispanic male with recurring urinary tract infections and hydronephrosis diagnosed with fibroepithelial polyps (FEPs). Despite multiple radiographic procedures, we were unable to accurately preoperatively diagnose FEPs. Here we demonstrate the difficulties in preoperative diagnosis and suggest that perhaps a combination of US and MRI in the setting of persistent urinary tract infections and flank pain may be the best approach for early diagnosis and conservative management, including less invasive treatment protocols.

Published
2015
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3. Science with the VO: Spectroscopic Studies of Herbig Ae/Be Stars

Author

Baines D., Gonzalez J., Arviset C., Barbarisi I., Laruelo A., Leon I., Landaluce I. Ortiz de, Osuna P., Rios C., and Salgado J.

Subjects
stars, variables, herbig ae/be, techniques, spectroscopic virtual, observatory tools, Astronomy, QB1-991
Abstract

The Virtual Observatory (VO) is opening up new ways of exploiting the huge amount of data provided by the ever growing number of ground-based and space facilities. Using VOSpec, a multi-wavelength spectral analysis tool developed by the ESA-VO Team at ESAC, and new developments on scripting with VOSpec (VOScript), we have started to undertake a comprehensive study of spectroscopic and photometric data in the VO on Herbig Ae/Be stars. By studying line strengths, variabilities and spectral energy distributions, from the X-ray to sub-millimeter ranges, we aim to gain insights into processes and disk properties of a large sample of these objects. This paper presents initial findings of the spectroscopic analysis and initial spectral energy distribution classifications.

Published
2012
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4. Low temperature synthesis of porous silicate ceramics

Author

Méndez Enríquez Y., Vlasova M., Leon I., Kakazey M.G., Dominguez-Patiño M., Isaeva L., and Tomila T.

Subjects
kaolin, feldspar, glass, polyurethane sponge, synthesis, Chemical technology, TP1-1185
Abstract

Impregnation of a polyurethane sponge with kaolin, feldspar, silica, fusible glass slurry followed by temperature treatment in air in the temperature range 800-1000 0 C leads to the formation of aluminosilicate ceramics with a set pore size. The low-temperature synthesis of porous ceramics is based on the stage-by-stage formation of low-temperature eutectics and thermodestruction of polyurethane sponge.

Published
2007
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5. Millimetre-wave laboratory study of glycinamide and search for it with ALMA toward Sagittarius B2(N)

Author

Kisiel, Z., Kolesniková, L., Belloche, A., Guillemin, J. -C., Pszczółkowski, L., Alonso, E. R., Garrod, R. T., Białkowska-Jaworska, E., León, I., Müller, H. S. P., Menten, K. M., and Alonso, J. L.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

Glycinamide is considered to be one of the possible precursors of the simplest amino acid glycine. Its only rotational spectrum reported so far has been in the cm-wave region. The aim of this work is to extend its laboratory spectrum into the mm wave region to support its searches in the ISM. Glycinamide was synthesised chemically and was studied with broadband rotational spectroscopy in the 90-329 GHz region. Tunneling across a low energy barrier between two symmetry equivalent configurations of the molecule resulted in splitting of each vibrational state and many perturbations in associated rotational energy levels, requiring careful coupled state fits for each vibrational doublet. We searched for emission of glycinamide in the imaging spectral line survey ReMoCA performed with ALMA toward Sgr B2(N). We report the first analysis of the mm-wave rotational spectrum of glycinamide, resulting in fitting to experimental measurement accuracy of over 1200 transition frequencies for the ground state tunneling doublet, of many lines for tunneling doublets for two singly excited vibrational states, and determination of precise vibrational separation in each doublet. We did not detect emission from glycinamide in the hot core Sgr B2(N1S). We found that glycinamide is at least seven times less abundant than aminoacetonitrile and 1.8 times less abundant than urea in this source. A comparison with results of astrochemical kinetics models for species related to glycinamide suggests that its abundance may be at least one order of magnitude below the upper limit obtained toward Sgr B2(N1S). This means that glycinamide emission in this source likely lies well below the spectral confusion limit in the frequency range covered by the ReMoCA survey. Targetting sources with a lower level of spectral confusion, such as the Galactic Center shocked region G+0.693-0.027, may be a promising avenue. [abridged], Comment: Accepted for publication in A&A

Published
2021
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6. Acute liver failure: Management update and prognosis

Author

Martínez-Martínez, L.M., Rosales-Sotomayor, G., Jasso-Baltazar, E.A., Torres-Díaz, J.A., Aguirre-Villarreal, D., Hurtado-Díaz de León, I., Páez-Zayas, V.M., Sánchez-Cedillo, A., Martínez-Vázquez, S.E., Tadeo-Espinoza, H.N., Guerrero-Cabrera, J.P., García-Alanis, M., and García-Juárez, I.

Published
2024
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7. PANEL DISCUSSION

Author

Ross, Gordon, primary, Chidsey, Charles A., additional, Goldberg, Leon I., additional, and Pitt, Bertram, additional

Published
2023
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9. Quasi-BIC laser enabled by high-contrast grating resonator for gas detection

Author

Zhang, H., Wang, T., Tian, J., Sun, J., Li, S., De Leon, I., Zaccaria, R. P., Peng, L., Gao, F., Lin, X., Chen, H., and Wang, G.

Subjects
Physics - Optics
Abstract

In this work, we propose and numerically investigate a two-dimensional microlaser based on the concept of bound states in the continuum (BIC). The device consists of a thin gain layer (Rhodamine 6G dye-doped silica) sandwiched between two high-contrast-grating layers. The structure supports various BIC modes upon a proper choice of topological parameters; in particular it supports a high-Q quasi-BIC mode when partially breaking a bound state in the continuum at $\Gamma$ point. The optically-pumped gain medium provides sufficient optical gain to compensate the quasi-BIC mode losses, enabling lasing with ultra-low pump threshold (fluence of 17 $\mu$J/cm$^2$) and very narrow optical linewidth in the visible range. This innovative device displays distinguished sensing performance for gas detection, and the emission wavelength sensitively shifts to the longer wavelength with the changing of environment refractive index (in order of $5 \times 10^{-4}$). The achieved bulk sensitivity is 221 nm/RIU with a high signal to noise ratio, and a record-high figure of merit reaches to 4420 RIU$^{-1}$. This ultracompact and low threshold quasi-BIC laser facilitated by the ultra-narrow resonance can serve as formidable candidate for on-chip gas sensor.

Published
2021

10. Rotational spectroscopic study and astronomical search for propiolamide in Sgr B2(N)

Author

Alonso, E. R., Kolesniková, L., Belloche, A., Mata, S., Garrod, R. T., Jabri, A., León, I., Guillemin, J. -C., Müller, H. S. P., Menten, K. M., and Alonso, J. L.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

For all the amides detected in the interstellar medium (ISM), the corresponding nitriles or isonitriles have also been detected in the ISM, some of which have relatively high abundances. Among the abundant nitriles for which the corresponding amide has not yet been detected is cyanoacetylene (HCCCN), whose amide counterpart is propiolamide (HCCC(O)NH$_2$). With the aim of supporting searches for this amide in the ISM, we provide a complete rotational study of propiolamide from 6 GHz to 440 GHz using rotational spectroscopic techniques in the frequency and time domain. We identified and measured more than 5500 distinct frequency lines of propiolamide and obtained accurate sets of spectroscopic parameters for the ground state and the three low-lying excited vibrational states. We used the ReMoCA spectral line survey performed with the Atacama Large Millimeter/submillimeter Array toward the star-forming region Sgr B2(N) to search for propiolamide. We report the nondetection of propiolamide toward the hot cores Sgr B2(N1S) and Sgr B2(N2). We find that propiolamide is at least 50 and 13 times less abundant than acetamide in Sgr B2(N1S) and Sgr B2(N2), respectively, indicating that the abundance difference between both amides is more pronounced by at least a factor of 8 and 2, respectively, than for their corresponding nitriles. Although propiolamide has yet to be included in astrochemical modeling networks, the observed upper limit to the ratio of propiolamide to acetamide seems consistent with the ratios of related species as determined from past simulations., Comment: The article will be published as a regular paper in Astronomy and Astrophysics

Published
2021
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11. The Solar Orbiter Science Activity Plan: translating solar and heliospheric physics questions into action

Author

Zouganelis, I., De Groof, A., Walsh, A. P., Williams, D. R., Mueller, D., Cyr, O. C. St, Auchere, F., Berghmans, D., Fludra, A., Horbury, T. S., Howard, R. A., Krucker, S., Maksimovic, M., Owen, C. J., Rodriiguez-Pacheco, J., Romoli, M., Solanki, S. K., Watson, C., Sanchez, L., Lefort, J., Osuna, P., Gilbert, H. R., Nieves-Chinchilla, T., Abbo, L., Alexandrova, O., Anastasiadis, A., Andretta, V., Antonucci, E., Appourchaux, T., Aran, A., Arge, C. N., Aulanier, G., Baker, D., Bale, S. D., Battaglia, M., Rubio, L. Bellot, Bemporad, A., Berthomier, M., Bocchialini, K., Bonnin, X., Brun, A. S., Bruno, R., Buchlin, E., Buechner, J., Bucik, R., Carcaboso, F., Carr, R., Carrasco-Blazquez, I., Cecconi, B., Cangas, I. Cernuda, Chen, C. H. K., Chitta, L. P., Chust, T., Dalmasse, K., D'Amicis, R., Da Deppo, V., De Marco, R., Dolei, S., Dolla, L., de Wit, T. Dudok, van Driel-Gesztelyi, L., Eastwood, J. P., Lara, F. Espinosa, Etesi, L., Fedorov, A., Felix-Redondo, F., Fineschi, S., Fleck, B., Fontaine, D., Fox, N. J., Gandorfer, A., Genot, V., Georgoulis, M. K., Gissot, S., Giunta, A., Gizon, L., Gomez-Herrero, R., Gontikakis, C., Graham, G., Green, L., Grundy, T., Haberreiter, M., Harra, L. K., Hassler, D. M., Hirzberger, J., Ho, G. C., Hurford, G., Innes, D., Issautier, K., James, A. W., Janitzek, N., Janvier, M., Jeffrey, N., Jenkins, J., Khotyaintsev, Y., Klein, K. -L., Kontar, E. P., Kontogiannis, I., Krafft, C., Krasnoselskikh, V., Kretzschmar, M., Labrosse, N., Lagg, A., Landini, F., Lavraud, B., Leon, I., Lepri, S. T., Lewis, G. R., Liewer, P., Linker, J., Livi, S., Long, D. M., Louarn, P., Malandraki, O., Maloney, S., Martinez-Pillet, V., Martinovic, M., Masson, A., Matthews, S., Matteini, L., Meyer-Vernet, N., Moraitis, K., Morton, R. J., Musset, S., Nicolaou, G., Nindos, A., O'Brien, H., Suarez, D. Orozco, Owens, M., Pancrazzi, M., Papaioannou, A., Parenti, S., Pariat, E., Patsourakos, S., Perrone, D., Peter, H., Pinto, R. F., Plainaki, C., Plettemeier, D., Plunkett, S. P., Raines, J. M., Raouafi, N., Reid, H., Retino, A., Rezeau, L., Rochus, P., Rodriguez, L., Rodriguez-Garcia, L., Roth, M., Rouillard, A. P., Sahraoui, F., Sasso, C., Schou, J., Schuehle, U., Sorriso-Valvo, L., Soucek, J., Spadaro, D., Stangalini, M., Stansby, D., Steller, M., Strugarek, A., Stverak, S., Susino, R., Telloni, D., Terasa, C., Teriaca, L., Toledo-Redondo, S., Iniesta, J. C. del Toro, Tsiropoula, G., Tsounis, A., Tziotziou, K., Valentini, F., Vaivads, A., Vecchio, A., Velli, M., Verbeeck, C., Verdini, A., Verscharen, D., Vilmer, N., Vourlidas, A., Wicks, R., Wimmer-Schweingruber, R. F., Wiegelmann, T., Young, P. R., and Zhukov, A. N.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Solar Orbiter is the first space mission observing the solar plasma both in situ and remotely, from a close distance, in and out of the ecliptic. The ultimate goal is to understand how the Sun produces and controls the heliosphere, filling the Solar System and driving the planetary environments. With six remote-sensing and four in-situ instrument suites, the coordination and planning of the operations are essential to address the following four top-level science questions: (1) What drives the solar wind and where does the coronal magnetic field originate? (2) How do solar transients drive heliospheric variability? (3) How do solar eruptions produce energetic particle radiation that fills the heliosphere? (4) How does the solar dynamo work and drive connections between the Sun and the heliosphere? Maximising the mission's science return requires considering the characteristics of each orbit, including the relative position of the spacecraft to Earth (affecting downlink rates), trajectory events (such as gravitational assist manoeuvres), and the phase of the solar activity cycle. Furthermore, since each orbit's science telemetry will be downloaded over the course of the following orbit, science operations must be planned at mission level, rather than at the level of individual orbits. It is important to explore the way in which those science questions are translated into an actual plan of observations that fits into the mission, thus ensuring that no opportunities are missed. First, the overarching goals are broken down into specific, answerable questions along with the required observations and the so-called Science Activity Plan (SAP) is developed to achieve this. The SAP groups objectives that require similar observations into Solar Orbiter Observing Plans (SOOPs), resulting in a strategic, top-level view of the optimal opportunities for science observations during the mission lifetime., Comment: 20 pages, 1 figure, accepted by Astronomy & Astrophysics

Published
2020
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12. Correspondence Between Perceived Pubertal Development and Hormone Levels in 9-10 Year-Olds From the Adolescent Brain Cognitive Development Study

Author

Herting, Megan M, Uban, Kristina A, Gonzalez, Marybel Robledo, Baker, Fiona C, Kan, Eric C, Thompson, Wesley K, Granger, Douglas A, Albaugh, Matthew D, Anokhin, Andrey P, Bagot, Kara S, Banich, Marie T, Barch, Deanna M, Baskin-Sommers, Arielle, Breslin, Florence J, Casey, BJ, Chaarani, Bader, Chang, Linda, Clark, Duncan B, Cloak, Christine C, Constable, R Todd, Cottler, Linda B, Dagher, Rada K, Dapretto, Mirella, Dick, Anthony S, Dosenbach, Nico, Dowling, Gayathri J, Dumas, Julie A, Edwards, Sarah, Ernst, Thomas, Fair, Damien A, Feldstein-Ewing, Sarah W, Freedman, Edward G, Fuemmeler, Bernard F, Garavan, Hugh, Gee, Dylan G, Giedd, Jay N, Glaser, Paul EA, Goldstone, Aimee, Gray, Kevin M, Hawes, Samuel W, Heath, Andrew C, Heitzeg, Mary M, Hewitt, John K, Heyser, Charles J, Hoffman, Elizabeth A, Huber, Rebekah S, Huestis, Marilyn A, Hyde, Luke W, Infante, M Alejandra, Ivanova, Masha Y, Jacobus, Joanna, Jernigan, Terry L, Karcher, Nicole R, Laird, Angela R, LeBlanc, Kimberly H, Lisdahl, Krista, Luciana, Monica, Luna, Beatriz, Maes, Hermine H, Marshall, Andrew T, Mason, Michael J, McGlade, Erin C, Morris, Amanda S, Nagel, Bonnie J, Neigh, Gretchen N, Palmer, Clare E, Paulus, Martin P, Potter, Alexandra S, Puttler, Leon I, Rajapakse, Nishadi, Rapuano, Kristina, Reeves, Gloria, Renshaw, Perry F, Schirda, Claudiu, Sher, Kenneth J, Sheth, Chandni, Shilling, Paul D, Squeglia, Lindsay M, Sutherland, Matthew T, Tapert, Susan F, Tomko, Rachel L, Yurgelun-Todd, Deborah, Wade, Natasha E, Weiss, Susan RB, Zucker, Robert A, and Sowell, Elizabeth R

Subjects
Paediatrics, Biomedical and Clinical Sciences, Mental Health, Clinical Research, Neurosciences, Social Determinants of Health, Women's Health, Pediatric, Behavioral and Social Science, Basic Behavioral and Social Science, Metabolic and endocrine, Good Health and Well Being, Adolescent, Adolescent Development, Child, Child Development, Cross-Sectional Studies, Dehydroepiandrosterone, Estradiol, Female, Gonadal Steroid Hormones, Humans, Male, Puberty, Self Report, Sexual Maturation, Socioeconomic Factors, Testosterone, adolescent brain cognitive development, salivary hormones, pubertal development scale, puberty, testosterone, dehydroepiandrosterone, estradiol, Clinical Sciences, Nutrition and Dietetics, Clinical sciences
Abstract

AimTo examine individual variability between perceived physical features and hormones of pubertal maturation in 9-10-year-old children as a function of sociodemographic characteristics.MethodsCross-sectional metrics of puberty were utilized from the baseline assessment of the Adolescent Brain Cognitive Development (ABCD) Study-a multi-site sample of 9-10 year-olds (n = 11,875)-and included perceived physical features via the pubertal development scale (PDS) and child salivary hormone levels (dehydroepiandrosterone and testosterone in all, and estradiol in females). Multi-level models examined the relationships among sociodemographic measures, physical features, and hormone levels. A group factor analysis (GFA) was implemented to extract latent variables of pubertal maturation that integrated both measures of perceived physical features and hormone levels.ResultsPDS summary scores indicated more males (70%) than females (31%) were prepubertal. Perceived physical features and hormone levels were significantly associated with child's weight status and income, such that more mature scores were observed among children that were overweight/obese or from households with low-income. Results from the GFA identified two latent factors that described individual differences in pubertal maturation among both females and males, with factor 1 driven by higher hormone levels, and factor 2 driven by perceived physical maturation. The correspondence between latent factor 1 scores (hormones) and latent factor 2 scores (perceived physical maturation) revealed synchronous and asynchronous relationships between hormones and concomitant physical features in this large young adolescent sample.ConclusionsSociodemographic measures were associated with both objective hormone and self-report physical measures of pubertal maturation in a large, diverse sample of 9-10 year-olds. The latent variables of pubertal maturation described a complex interplay between perceived physical changes and hormone levels that hallmark sexual maturation, which future studies can examine in relation to trajectories of brain maturation, risk/resilience to substance use, and other mental health outcomes.

Published
2021

13. Correspondence Between Perceived Pubertal Development and Hormone Levels in 9-10 Year-Olds From the Adolescent Brain Cognitive Development Study.

Author

Herting, Megan M, Uban, Kristina A, Gonzalez, Marybel Robledo, Baker, Fiona C, Kan, Eric C, Thompson, Wesley K, Granger, Douglas A, Albaugh, Matthew D, Anokhin, Andrey P, Bagot, Kara S, Banich, Marie T, Barch, Deanna M, Baskin-Sommers, Arielle, Breslin, Florence J, Casey, BJ, Chaarani, Bader, Chang, Linda, Clark, Duncan B, Cloak, Christine C, Constable, R Todd, Cottler, Linda B, Dagher, Rada K, Dapretto, Mirella, Dick, Anthony S, Dosenbach, Nico, Dowling, Gayathri J, Dumas, Julie A, Edwards, Sarah, Ernst, Thomas, Fair, Damien A, Feldstein-Ewing, Sarah W, Freedman, Edward G, Fuemmeler, Bernard F, Garavan, Hugh, Gee, Dylan G, Giedd, Jay N, Glaser, Paul EA, Goldstone, Aimee, Gray, Kevin M, Hawes, Samuel W, Heath, Andrew C, Heitzeg, Mary M, Hewitt, John K, Heyser, Charles J, Hoffman, Elizabeth A, Huber, Rebekah S, Huestis, Marilyn A, Hyde, Luke W, Infante, M Alejandra, Ivanova, Masha Y, Jacobus, Joanna, Jernigan, Terry L, Karcher, Nicole R, Laird, Angela R, LeBlanc, Kimberly H, Lisdahl, Krista, Luciana, Monica, Luna, Beatriz, Maes, Hermine H, Marshall, Andrew T, Mason, Michael J, McGlade, Erin C, Morris, Amanda S, Nagel, Bonnie J, Neigh, Gretchen N, Palmer, Clare E, Paulus, Martin P, Potter, Alexandra S, Puttler, Leon I, Rajapakse, Nishadi, Rapuano, Kristina, Reeves, Gloria, Renshaw, Perry F, Schirda, Claudiu, Sher, Kenneth J, Sheth, Chandni, Shilling, Paul D, Squeglia, Lindsay M, Sutherland, Matthew T, Tapert, Susan F, Tomko, Rachel L, Yurgelun-Todd, Deborah, Wade, Natasha E, Weiss, Susan RB, Zucker, Robert A, and Sowell, Elizabeth R

Subjects
Humans, Dehydroepiandrosterone, Testosterone, Estradiol, Gonadal Steroid Hormones, Cross-Sectional Studies, Adolescent Development, Child Development, Puberty, Sexual Maturation, Socioeconomic Factors, Adolescent, Child, Female, Male, Self Report, adolescent brain cognitive development, dehydroepiandrosterone, estradiol, pubertal development scale, puberty, salivary hormones, testosterone, Pediatric, Behavioral and Social Science, Prevention, Pediatric Research Initiative, Clinical Research, Mental Health, Basic Behavioral and Social Science, Contraception/Reproduction, Mental health, Clinical Sciences, Nutrition and Dietetics
Abstract

AimTo examine individual variability between perceived physical features and hormones of pubertal maturation in 9-10-year-old children as a function of sociodemographic characteristics.MethodsCross-sectional metrics of puberty were utilized from the baseline assessment of the Adolescent Brain Cognitive Development (ABCD) Study-a multi-site sample of 9-10 year-olds (n = 11,875)-and included perceived physical features via the pubertal development scale (PDS) and child salivary hormone levels (dehydroepiandrosterone and testosterone in all, and estradiol in females). Multi-level models examined the relationships among sociodemographic measures, physical features, and hormone levels. A group factor analysis (GFA) was implemented to extract latent variables of pubertal maturation that integrated both measures of perceived physical features and hormone levels.ResultsPDS summary scores indicated more males (70%) than females (31%) were prepubertal. Perceived physical features and hormone levels were significantly associated with child's weight status and income, such that more mature scores were observed among children that were overweight/obese or from households with low-income. Results from the GFA identified two latent factors that described individual differences in pubertal maturation among both females and males, with factor 1 driven by higher hormone levels, and factor 2 driven by perceived physical maturation. The correspondence between latent factor 1 scores (hormones) and latent factor 2 scores (perceived physical maturation) revealed synchronous and asynchronous relationships between hormones and concomitant physical features in this large young adolescent sample.ConclusionsSociodemographic measures were associated with both objective hormone and self-report physical measures of pubertal maturation in a large, diverse sample of 9-10 year-olds. The latent variables of pubertal maturation described a complex interplay between perceived physical changes and hormone levels that hallmark sexual maturation, which future studies can examine in relation to trajectories of brain maturation, risk/resilience to substance use, and other mental health outcomes.

Published
2020

24. Spanish multidisciplinary clinical practice guidelines for Anderson–Fabry disease in adults. I. Method and recommendations

Author

Calderón Sandubete, E.J., Briones Pérez de la Blanca, E., Alonso-Ortiz del Río, C., Santamaría Olmo, R., López Mendoza, M., Barcos Martínez, M., Márquez Infante, C., Marín-León, I., Posada de la Paz, Manuel, Castellano, Pilar Giraldo, Blanes, Juan Ramón Gimeno, Navarro, Encarnación Guillén, Rodríguez, Mónica López, Arduán, Alberto Ortiz, Guzmán, Jaime Díaz, Martínez, Paz Latre, Villalba, Jordi Cruz, and Pérez, José María Carrión

Published
2019
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35. Impact of refitted <scp>race‐free eGFR</scp> formula on obesity pharmacotherapy options

Author

Babak J. Orandi, Chandler McLeod, Rhiannon D. Reed, Vineeta Kumar, Leon I. Igel, Louis J. Aronne, Robert M. Cannon, Cora E. Lewis, and Jayme E. Locke

Subjects
Cohort Studies, Nutrition and Dietetics, Endocrinology, Creatinine, Endocrinology, Diabetes and Metabolism, Humans, Medicine (miscellaneous), Obesity, Renal Insufficiency, Chronic, Nutrition Surveys, Glomerular Filtration Rate
Abstract

Recent changes to the Chronic Kidney Disease Epidemiology Collaboration estimated glomerular filtration rate (eGFR) formula (2021 CKD-EPI) removed race from the 2009 formula, increasing the number of Black people classified as having CKD, but these changes may impact eligibility and/or dosing for antiobesity medications. This study estimated the number of people with obesity nationwide who might have pharmacotherapy options impacted by the new formula.Using National Health and Nutrition Examination Survey (NHANES) cohort study data, the number of people eligible for antiobesity medication was estimated, and the number who would require a dosage reduction or would no longer be eligible for specific medications based on the new eGFR formula was also estimated.Among 16,412,571 Black and 109,654,751 non-Black people eligible for antiobesity medication, 911,336 (6.1%) Black and 6,925,492 (6.6%) non-Black people had ≥CKD stage 3 by the 2009 CKD-EPI formula. Applying the 2021 CKD-EPI formula, 1,260,969 (8.5%) Black people and 4,989,919 (4.7%) non-Black people had ≥CKD stage 3. For medications requiring renal adjustment, the number of Black people who would require a lower dose or be precluded from using a medication increased by 24.7% to 50.2%.These findings highlight the importance of measuring-rather than estimating-GFR in Black people with CKD when considering many antiobesity pharmacotherapy options.

Published
2022
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43. El tratamiento con implantes insertados en localizaciones alveolares regeneradas con betafosfato tricalcico.

Author

Grau Leon, I. B., Guerra Cobian, O., Sanchez Silot, C., and Garcia Romero, J. L.

Abstract

Copyright of Avances en Odontoestomatologia is the property of Ediciones Avances SL and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023

44. Prognostic Value of Cardiac MRI and FDG PET in Cardiac Sarcoidosis: A Systematic Review and Meta-Analysis

Author

Aitken, Matthew, primary, Davidson, Malcolm, additional, Chan, Michael V., additional, Urzua Fresno, Camila, additional, Vasquez, Leon I., additional, Huo, Ya R., additional, McAllister, Brylie J., additional, Broncano, Jordi, additional, Thavendiranathan, Paaladinesh, additional, McInnes, Matthew D. F., additional, Iwanochko, Mark R., additional, Balter, Meyer, additional, Moayedi, Yasbanoo, additional, Farrell, Ashley, additional, and Hanneman, Kate, additional

Published
2023
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50. Obesity: When to consider medication: These 4 cases illustrate how weight loss drugs--including the 4 newest--can be integrated into a treatment plan that includes diet, exercise, and behavior modification

Author

Saunders, Katherine H., Shukla, Alpana P., Igel, Leon I., and Aronne, Louis J.

Subjects
United States. Food and Drug Administration, Obesity, Type 2 diabetes, Anti-obesity agents, Cholesterol, Blood glucose, Weight loss, Diet, Health, Obesity Society
Abstract

Modest weight loss of 5% to 10% among patients who are overweight or obese can result in a clinically relevant reduction in cardiovascular (CV) disease risk. (1) This amount of [...]

Published
2018

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