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1. Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Trials.

Author

Sreenivasan, Jayakumar, Reddy, Rohin, Jamil, Yasser, Malik, Aaqib, Chamie, Daniel, Howard, James, Nanna, Michael, Mintz, Gary, Maehara, Akiko, Ali, Ziad, Moses, Jeffrey, Chen, Shao-Liang, Chieffo, Alaide, Colombo, Antonio, Leon, Martin, Lansky, Alexandra, and Ahmad, Yousif

Subjects
intravascular ultrasound, meta‐analysis, optical coherence tomography, percutaneous coronary intervention, Humans, Coronary Artery Disease, Coronary Angiography, Percutaneous Coronary Intervention, Ultrasonography, Interventional, Randomized Controlled Trials as Topic, Thrombosis, Treatment Outcome, Death
Abstract

BACKGROUND: Despite the initial evidence supporting the utility of intravascular imaging to guide percutaneous coronary intervention (PCI), adoption remains low. Recent new trial data have become available. An updated study-level meta-analysis comparing intravascular imaging to angiography to guide PCI was performed. This study aimed to evaluate the clinical outcomes of intravascular imaging-guided PCI compared with angiography-guided PCI. METHODS AND RESULTS: A random-effects meta-analysis was performed on the basis of the intention-to-treat principle. The primary outcomes were major adverse cardiac events, cardiac death, and all-cause death. Mixed-effects meta-regression was performed to investigate the impact of complex PCI on the primary outcomes. A total of 16 trials with 7814 patients were included. The weighted mean follow-up duration was 28.8 months. Intravascular imaging led to a lower risk of major adverse cardiac events (relative risk [RR], 0.67 [95% CI, 0.55-0.82]; P

Published
2024

2. Cerebral Embolic Protection in Transcatheter Aortic Valve Replacement.

Author

Iskander, Mina, Jamil, Yasser, Forrest, John, Madhavan, Mahesh, Makkar, Raj, Leon, Martin, Lansky, Alexandra, and Ahmad, Yousif

Subjects
Aortic stenosis, Cerebral protection, Stroke, TAVR
Abstract

Transcatheter aortic valve replacement (TAVR) is a treatment option for patients with symptomatic severe aortic stenosis across the entire spectrum of surgical risk. Recent trial data have led to the expansion of TAVR into lower-risk patients. With iterative technological advances and successive increases in procedural experience, the occurrence of complications following TAVR has declined. One of the most feared complications remains stroke, and patients consider stroke a worse outcome than death. There has therefore been great interest in strategies to mitigate the risk of stroke in patients undergoing TAVR. In this paper, we will discuss mechanisms and predictors of stroke after TAVR and describe the currently available cerebral embolic protection devices, including their design and relevant clinical studies pertaining to their use. We will also review the current overall evidence base for cerebral embolic protection during TAVR and ongoing randomized controlled trials. Finally, we will discuss our pragmatic recommendations for the use of cerebral embolic protection devices in patients undergoing TAVR.

Published
2023

4. Deep Learning for Echo Analysis, Tracking, and Evaluation of Mitral Regurgitation (DELINEATE-MR)

Author

Long, Aaron, Haggerty, Christopher M., Finer, Joshua, Hartzel, Dustin, Jing, Linyuan, Keivani, Azadeh, Kelsey, Christopher, Rocha, Daniel, Ruhl, Jeffrey, vanMaanen, David, Metser, Gil, Duffy, Eamon, Mawson, Thomas, Maurer, Mathew, Einstein, Andrew J., Beecy, Ashley, Kumaraiah, Deepa, Homma, Shunichi, Liu, Qi, Agarwal, Vratika, Lebehn, Mark, Leon, Martin, Hahn, Rebecca, Elias, Pierre, and Poterucha, Timothy J.

Published
2024
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5. Clinical Research on Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valve Disease: Principles, Challenges, and an Agenda for the Future.

Author

Ahmad, Yousif, Madhavan, Mahesh, Baron, Suzanne, Forrest, John, Borger, Michael, Leipsic, Jonathon, Cavalcante, João, Wang, Dee, McCarthy, Patrick, Szerlip, Molly, Kapadia, Samir, Makkar, Raj, Mack, Michael, Leon, Martin, and Cohen, David

Subjects
Clinical research, Clinical trials, Severe aortic stenosis, Transcatheter aortic valve replacement
Abstract

Bicuspid aortic valve disease (BAVD) is present in up to half of all patients referred for surgical aortic valve replacement (SAVR) yet was an exclusion criterion for all randomized controlled trials (RCTs) comparing transcatheter aortic valve replacement (TAVR) to SAVR. Nonetheless, approximately 10% of patients currently treated with TAVR have BAVD and available observational data for performing TAVR in these patients are limited by selection bias. Many in the cardiovascular community have advocated for RCTs in this population, but none have been performed. The Heart Valve Collaboratory (HVC) is a multidisciplinary community of stakeholders with the aim of creating significant advances in valvular heart disease by stimulating clinical research, engaging in educational activities, and advancing regulatory science. In December 2020, the HVC hosted a Global Multidisciplinary workshop involving over 100 international experts in the field. Following this 2-day symposium, working groups with varied expertise were convened to discuss BAVD, including the need for and design of RCTs. This review, conducted under the auspices of the HVC, summarizes available data and knowledge gaps regarding procedural therapy for BAVD, outlining specific challenges for trials in this population. We also propose several potential studies that could be performed and discuss respective strengths and weaknesses of each approach. Finally, we present a roadmap for future directions in clinical research in TAVR for BAVD with an emphasis both on RCTs and also prospective registries focused on disease phenotyping to develop parameters and risk scores that could ultimately be applied to patients to inform clinical decision-making.

Published
2023

6. Long-Term Outcomes of Randomized Controlled Trials Comparing Percutaneous Left Atrial Appendage Closure to Oral Anticoagulation for Nonvalvular Atrial Fibrillation: A Meta-Analysis.

Author

Madhavan, Mahesh, Howard, James, Brener, Michael, Der Nigoghossian, Caroline, Chen, Shmuel, Makkar, Raj, Osmancik, Pavel, Reddy, Vivek, Holmes, David, Stone, Gregg, Leon, Martin, and Ahmad, Yousif

Subjects
Atrial fibrillation, Left atrial appendage closure, Meta-analysis, Stroke
Abstract

BACKGROUND: Oral anticoagulation (OAC) has been considered the standard of care for stroke prophylaxis for patients with nonvalvular atrial fibrillation; however, many individuals are unable or unwilling to take long-term OAC. The safety and efficacy of percutaneous left atrial appendage closure (LAAC) have been controversial, and new trial data have recently emerged. We therefore sought to perform an updated meta-analysis of randomized clinical trials (RCTs) comparing OAC to percutaneous LAAC, focusing on individual clinical endpoints. METHODS: We performed a systematic search of the MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials from January 2000 through December 2021 for all RCTs comparing percutaneous LAAC to OAC in patients with nonvalvular atrial fibrillation. Fixed and random effects meta-analyses of hazard ratios (HRs) were performed using the longest follow-up duration available by intention-to-treat. The prespecified primary endpoint was all-cause mortality. RESULTS: Three RCTs enrolling 1516 patients were identified. The weighted mean follow-up was 54.7 months. LAAC was associated with a reduced risk of all-cause mortality (HR 0.76; 95% confidence interval [CI], 0.59-0.96; p = 0.023), hemorrhagic stroke (HR 0.24; 95% CI, 0.09-0.61; p = 0.003), and major nonprocedural bleeding (HR 0.52; 95% CI, 0.37-0.74; p < 0.001). There was no significant difference between LAAC and OAC for any other endpoints. CONCLUSIONS: The available evidence from RCTs suggests LAAC therapy is associated with reduced long-term risk of death compared with OAC. This may be driven by reductions in hemorrhagic stroke and major nonprocedural bleeding. There were no significant differences in the risk of all stroke. Further large-scale clinical trials are needed to validate these findings.

Published
2023

7. Severity of and Recovery From Anemia After Transcatheter Aortic Valve Replacement: An Analysis of the PARTNER Trials and Registries.

Author

Bhardwaj, Bhaskar, Kolte, Dhaval, Zhao, Yanglu, Alu, Maria, Zahr, Firas, Passeri, Jonathan, Inglessis, Ignacio, Vlahakes, Gus, Garcia, Santiago, Cohen, David, Makkar, Raj, Kodali, Susheel, Thourani, Vinod, Kapadia, Samir, Palacios, Igor, Leon, Martin, Smith, Craig, Mack, Michael, and Elmariah, Sammy

Subjects
anemia, anemia recovery, aortic stenosis, transcatheter aortic valve implantation, transfusion
Abstract

BACKGROUND: Anemia is associated with increased mortality in patients undergoing transcatheter aortic valve replacement (TAVR); however, data on the effect of the severity of and recovery from anemia on clinical outcomes are limited. This study examined the impact of the severity of and recovery from anemia after TAVR. METHODS: Patients with symptomatic, severe aortic stenosis across all surgical risk groups from the Placement of Aortic Transcatheter Valves (PARTNER) I, II, and III trials and registries who underwent TAVR were analyzed. Baseline anemia was defined as mild (hemoglobin [Hb] level ≥11.0 g/dL and

Published
2023

8. Long term safety and outcomes after atrial shunting for heart failure with preserved or mildly reduced ejection fraction: 5-year and 3-year follow-up in the REDUCE LAP-HF I and II trials

Author

Litwin, Sheldon E., Komtebedde, Jan, Borlaug, Barry A., Kaye, David M., Hasenfuβ, Gerd, Kawash, Rami, Hoendermis, Elke, Hummel, Scott L., Cikes, Maja, Gustafsson, Finn, Chung, Eugene S., Mohan, Rajeev C., Sverdlov, Aaron L., Swarup, Vijendra, Winkler, Sebastian, Hayward, Christopher S., Bergmann, Martin W., Bugger, Heiko, McKenzie, Scott, Nair, Ajith, Rieth, Andreas, Burkhoff, Daniel, Cutlip, Donald E., Solomon, Scott D., van Veldhuisen, Dirk J., Leon, Martin B., and Shah, Sanjiv J.

Published
2024
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9. Neutrophil‐to‐Lymphocyte Ratios in Patients Undergoing Aortic Valve Replacement: The PARTNER Trials and Registries

Author

Shahim, Bahira, Redfors, Björn, Lindman, Brian R, Chen, Shmuel, Dahlen, Torsten, Nazif, Tamim, Kapadia, Samir, Gertz, Zachary M, Crowley, Aaron C, Li, Ditian, Thourani, Vinod H, Kodali, Susheel K, Zajarias, Alan, Babaliaros, Vasilis C, Guyton, Robert A, Elmariah, Sammy, Herrmann, Howard C, Cohen, David J, Mack, Michael J, Smith, Craig R, Leon, Martin B, and George, Isaac

Subjects
Heart Disease, Clinical Research, Transplantation, Cardiovascular, Aortic Valve, Aortic Valve Stenosis, Heart Valve Prosthesis Implantation, Humans, Lymphocytes, Neutrophils, Registries, Risk Factors, Severity of Illness Index, Treatment Outcome, aortic stenosis, neutrophil-to-lymphocyte ratio, NLR, surgical aortic valve replacement, transcatheter aortic valve replacement, neutrophil‐to‐lymphocyte ratio, Cardiorespiratory Medicine and Haematology
Abstract

Background The neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic inflammation has been associated with worse prognosis in several chronic disease states, including heart failure. However, few data exist on the prognostic impact of elevated baseline NLR or change in NLR levels during follow-up in patients undergoing transcatheter or surgical aortic valve replacement (TAVR or SAVR) for aortic stenosis. Methods and Results NLR was available in 5881 patients with severe aortic stenosis receiving TAVR or SAVR in PARTNER (Placement of Aortic Transcatheter Valves) I, II, and S3 trials/registries (median [Q1, Q3] NLR, 3.30 [2.40, 4.90]); mean NLR, 4.10; range, 0.5-24.9) and was evaluated as continuous variable and categorical tertiles (low: NLR ≤2.70, n=1963; intermediate: NLR 2.70-4.20, n=1958; high: NLR ≥4.20, n=1960). No patients had known baseline infection. High baseline NLR was associated with increased risk of death or rehospitalization at 3 years (58.4% versus 41.0%; adjusted hazard ratio [aHR], 1.39; 95% CI, 1.18-1.63; P

Published
2022

12. 2-Year Outcomes of an Atrial Shunt Device in HFpEF/HFmrEF: Results From REDUCE LAP-HF II

Author

Gustafsson, Finn, Petrie, Mark C., Komtebedde, Jan, Swarup, Vijendra, Winkler, Sebastian, Hasenfuß, Gerd, Borlaug, Barry A., Mohan, Rajeev C., Flaherty, James D., Sverdlov, Aaron L., Fail, Peter S., Chung, Eugene S., Lurz, Philipp, Lilly, Scott, Kaye, David M., Cleland, John G.F., Cikes, Maja, Leon, Martin B., Cutlip, Donald E., van Veldhuisen, Dirk J., Solomon, Scott D., and Shah, Sanjiv J.

Published
2024
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16. Effects of tricuspid transcatheter edge-to-edge repair on tricuspid annulus diameter - Data from the TriValve registry

Author

Russo, Giulio, Hahn, Rebecca T., Alessandrini, Hannes, Andreas, Martin, Badano, Luigi P., Braun, Daniel, Connelly, Kim A., Denti, Paolo, Estevez-Loureiro, Rodrigo, Fam, Neil, Gavazzoni, Mara, Hausleiter, Joerg, Himbert, Dominique, Kalbacher, Daniel, Latib, Azeem, Lubos, Edith, Ludwig, Sebastian, Lurz, Philipp, Monivas, Vanessa, Nickenig, Georg, Pedicino, Daniela, Pedrazzini, Giovanni, Pozzoli, Alberto, Praz, Fabien, Rodes-Cabau, Joseph, Rommel, Karl-Philipp, Schofer, Joachim, Sievert, Horst, Tang, Gilbert, Thiele, Holger, Unterhuber, Matthias, von Bardeleben, Ralph Stephan, Webb, John, Windecker, Stephan, Leon, Martin, Maisano, Francesco, and Taramasso, Maurizio

Published
2024
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17. Patient-Prosthesis Mismatch After Surgical Aortic Valve Replacement: Analysis of the PARTNER Trials

Author

Thourani, Vinod H., Abbas, Amr E., Ternacle, Julien, Hahn, Rebecca T., Makkar, Raj, Kodali, Susheel K., George, Isaac, Kapadia, Samir, Svensson, Lars G., Szeto, Wilson Y., Herrmann, Howard C., Ailawadi, Gorav, Leipsic, Jonathon, Blanke, Philipp, Webb, John, Jaber, Wael A., Russo, Mark, Malaisrie, S. Chris, Yadav, Pradeep, Clavel, Marie-Annick, Khalique, Omar K., Weissman, Neil J., Douglas, Pamela, Bax, Jeroen, Dahou, Abdellaziz, Xu, Ke, Bapat, Vinayak, Alu, Maria C., Leon, Martin B., Mack, Michael J., and Pibarot, Philippe

Published
2024
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18. Managing Implanted Cardiac Electronic Devices in Patients With Severe Tricuspid Regurgitation: JACC State-of-the-Art Review

Author

Hahn, Rebecca T., Wilkoff, Bruce Larry, Kodali, Susheel, Birgersdotter-Green, Ulrika Maria, Ailawadi, Gorav, Addetia, Karima, Andreas, Martin, Auricchio, Angelo, Ehlert, Frederick, George, Isaac, Gupta, Aakriti, Harrison, Rachel, Ho, Edwin C., Kusumoto, Fred, Latib, Azeem, O’Gara, Patrick, Patton, Kristen K., Pinney, Sean, Zeitler, Emily P., Mack, Michael J., Leon, Martin B., and Epstein, Laurence M.

Published
2024
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19. Transcatheter aortic valve implantation in patients with high-risk symptomatic native aortic regurgitation (ALIGN-AR): a prospective, multicentre, single-arm study

Author

Vahl, Torsten P, Thourani, Vinod H, Makkar, Raj R, Hamid, Nadira, Khalique, Omar K, Daniels, David, McCabe, James M, Satler, Lowell, Russo, Mark, Cheng, Wen, George, Isaac, Aldea, Gabriel, Sheridan, Brett, Kereiakes, Dean, Golwala, Harsh, Zahr, Firas, Chetcuti, Stanley, Yadav, Pradeep, Kodali, Susheel K, Treede, Hendrik, Baldus, Stephan, Amoroso, Nicholas, Ranard, Lauren S, Pinto, Duane S, and Leon, Martin B

Published
2024
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20. Prediction of Mortality and Heart Failure Hospitalization After Transcatheter Tricuspid Valve Interventions: Validation of TRISCORE

Author

Adamo, Marianna, Russo, Giulio, Pagnesi, Matteo, Pancaldi, Edoardo, Alessandrini, Hannes, Andreas, Martin, Badano, Luigi P., Braun, Daniel, Connelly, Kim A., Denti, Paolo, Estevez-Loureiro, Rodrigo, Fam, Neil, Gavazzoni, Mara, Hahn, Rebecca T., Harr, Claudia, Hausleiter, Joerg, Himbert, Dominique, Kalbacher, Daniel, Ho, Edwin, Latib, Azeem, Lubos, Edith, Ludwig, Sebastian, Lupi, Laura, Lurz, Philipp, Monivas, Vanessa, Nickenig, Georg, Pedicino, Daniela, Pedrazzini, Giovanni, Pozzoli, Alberto, Marafon, Denise Pires, Pastorino, Roberta, Praz, Fabien, Rodes-Cabau, Joseph, Besler, Christian, Schöber, Anne Rebecca, Schofer, Joachim, Scotti, Andrea, Piayda, Kerstin, Sievert, Horst, Tang, Gilbert H.L., Sticchi, Alessandro, Messika-Zeitoun, David, Thiele, Holger, Schlotter, Florian, von Bardeleben, Ralph Stephan, Webb, John, Dreyfus, Julien, Windecker, Stephan, Leon, Martin, Maisano, Francesco, Metra, Marco, and Taramasso, Maurizio

Published
2024
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22. Early outcomes following transatrial transcatheter mitral valve replacement in patients with severe mitral annular calcification

Author

Brener, Michael I., Hamandi, Mohanad, Hong, Estee, Pizano, Alejandro, Harloff, Morgan T., Garner, Evan F., El Sabbagh, Abdallah, Kaple, Ryan K., Geirsson, Arnar, Deaton, David W., Islam, Ashequl M., Veeregandham, Ramesh, Bapat, Vinayak, Khalique, Omar K., Ning, Yuming, Kurlansky, Paul A., Grayburn, Paul A., Nazif, Tamim M., Kodali, Susheel K., Leon, Martin B., Borger, Michael A., Lee, Raymond, Kohli, Keshav, Yoganathan, Ajit P., Colli, Andrea, Guerrero, Mayra E., Davies, James E., Eudailey, Kyle W., Kaneko, Tsuyoshi, Nguyen, Tom C., Russell, Hyde, Smith, Robert L., III, and George, Isaac

Published
2024
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24. Off-Label Use of Peripheral Paclitaxel Drug-Coated Balloons in Management of Recurrent Coronary In-Stent Restenosis

Author

Madhavan, Mahesh V., Hakemi, Emad, Neeranjun, Rishi, Rahim, Hussein M., Nouri, Shayan Nabavi, Flattery, Erin, Prasad, Megha, Collins, Michael B., Karmpaliotis, Dimitri, Ali, Ziad A., Parikh, Sahil A., Vahl, Torsten P., Patel, Amisha, Nazif, Tamim M., Fall, Khady N., Maehara, Akiko, Leon, Martin B., Kirtane, Ajay J., and Moses, Jeffrey W.

Published
2024
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26. Early Surgery for Patients With Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled Trials.

Author

Ahmad, Yousif, Howard, James, Seligman, Henry, Arnold, Ahran, Madhavan, Mahesh, Forrest, John, Geirsson, Arnar, Mack, Michael, Lansky, Alexandra, and Leon, Martin

Subjects
Meta-analysis, randomized controlled trials, severe aortic stenosis
Abstract

BACKGROUND: Guidelines provide class I recommendations for aortic valve intervention for patients with symptomatic severe aortic stenosis (AS) or reduced ejection fraction, but the cornerstone of management for asymptomatic patients has been watchful waiting. This is based on historical nonrandomized data, but randomized controlled trials (RCTs) have now been performed of early surgical aortic valve replacement (SAVR) for asymptomatic severe AS. We performed a meta-analysis of RCTs comparing early SAVR to watchful waiting for asymptomatic severe AS, focusing on individual end points of death and heart failure (HF) hospitalization. METHODS: We systematically identified all RCTs comparing early SAVR to watchful waiting in patients with asymptomatic severe AS and synthesized the data in a random-effects meta-analysis. The prespecified primary end point was all-cause mortality. RESULTS: Two trials randomizing 302 patients were included. Early SAVR lead to a 55% reduction in all-cause mortality (hazard ratio, 0.45; 95% confidence interval, 0.24-0.85; P = .014). There was no heterogeneity (I2 = 0.0%). Early SAVR also lead to a 79% reduction in HF hospitalization (hazard ratio, 0.21; 95% confidence interval, 0.05-0.96; P = .044). CONCLUSIONS: In patients with severe asymptomatic AS and normal ejection fraction, early SAVR reduces death and HF hospitalization compared to initial conservative management. This challenges current treatment standards and has implications for the clinical care of these patients and for guidelines.

Published
2022

27. Concomitant Left Atrial Appendage Occlusion and Transcatheter Aortic Valve Replacement Among Patients With Atrial Fibrillation

Author

Kapadia, Samir R., Krishnaswamy, Amar, Whisenant, Brian, Potluri, Srinivasa, Iyer, Vijay, Aragon, Joseph, Gideon, Philip, Strote, Justin, Leonardi, Robert, Agarwal, Himanshu, Larrain, German, Sanchez, Carlos, Panaich, Sidakpal S., Harvey, James, Vahl, Torsten, Menon, Venu, Wolski, Kathy, Wang, Qiuqing, and Leon, Martin B.

Published
2024
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30. Presence and Relevance of Myocardial Bridge in LAD-PCI of CTO and Non-CTO Lesions

Author

Yamamoto, Kei, Sugizaki, Yoichiro, Karmpaliotis, Dimitri, Sato, Takao, Matsumura, Mitsuaki, Narui, Shuro, Yamamoto, Myong Hwa, Fall, Khady N., James, Elizabeth I., Glinski, John B., Rabban, Maya L., Prasad, Megha, Ng, Vivian G., Sethi, Sanjum S., Nazif, Tamim M., Parikh, Sahil A., Vahl, Torsten P., Ali, Ziad A., Rabbani, LeRoy E., Collins, Michael B., Leon, Martin B., McEntegart, Margaret, Moses, Jeffrey W., Kirtane, Ajay J., Ochiai, Masahiko, Mintz, Gary S., and Maehara, Akiko

Published
2024
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32. The impact of perioperative stroke and delirium on outcomes after surgical aortic valve replacement

Author

Miller, Marissa A., Taddei-Peters, Wendy C., Jeffries, Neal O., Buxton, Dennis, Geller, Nancy L., Gordon, David, Burke, Catherine, Lee, Albert, Smith, Tyrone, Moy, Claudia S., Gombos, Ilana Kogan, Weisel, Richard, Gardner, Timothy J., O'Gara, Patrick T., Rose, Eric A., Gelijns, Annetine C., Parides, Michael K., Ascheim, Deborah D., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, Shah, Kinjal, Overbey, Jessica R., Pan, Stephanie, Chang, Helena, Chase, Melissa, Goldfarb, Seth, Gupta, Lopa, Kirkwood, Katherine, Dobrev, Edlira, Levitan, Ron, O'Sullivan, Karen, Santos, Milerva, Ye, Xia, Mack, Michael, Winkle, Rachelle, Boswell, Haley, Fenlon, Amanda, Johnson, Melissa, Jones, Jessica, Kolb, Megan, Lam, Sarah, Miranda, Lucy, Ward, Jackie, Whitman, Renessa, Zingler, Brittany, Ryan, William, Smith, Robert L., Grayburn, Paul, Nosnik, Pedro, Gillinov, A. Marc, Blackstone, Eugene H., Moazami, Nader, Starling, Randall C., Barzilai, Benico, Grimm, Richard A., Soltesz, Edward G., Katzan, Irene, Strippy, Brian, Smith, Shoi, Garcia, Michelle, Alice bowman, Mary, Geither, Carrie, Wang, Robert, Argenziano, Michael, Borger, Michael, Takayama, Hiroo, Leon, Martin B., Goldsmith, Lyn, Schwartz, Allan, Sookraj, Nadia, McCright-Gill, Talaya, Sreekanth, Sowmya, McCullough, Jock N., Iribarne, Alexander, DeSimone, Joseph P., DiScipio, Anthony W., Stokes, Henry, Ivany, Amanda St., Petty, Gaylin, Smith, Peter K., Alexander, John H., Milano, Carmelo A., Glower, Donald D., Huber, Joel, Morganlander, Joel, Mathew, Joseph P., Welsh, Stacey, Casalinova, Sarah, Johnson, Victoria, Lane, Kathleen, Smith, Derek, Tipton, Greg, Berry, Mark F., Williams, Judson B., Englum, Brian, Hartwig, Matthew, Thourani, Vinod H., Guyton, Robert, Lattouf, Omar, Chen, Edward, Vega, J. David, Baer, Jefferson, Nguyen, Duc, Halkos, Michael, Baio, Kim, Prince, Tamara, Cook, Natascha, Neill, Alexis A., Voisine, Pierre, Senechal, Mario, Dagenais, François, Laforce, Robert, Jr., O'Connor, Kim, Dussault, Gladys, Caouette, Manon, Tremblay, Hugo, Gagne, Nathalie, Dumont, Julie, Landry, Patricia, Groh, Mark A., Trichon, Benjamin H., Binns, Oliver A., Ely, Stephen W., Johnson, Alan M., Hansen, Todd H., Short, John G., Taylor, Reid D., Mangusan, Ralph, Nanney, Tracy, Aubart, Holly, Cross, Kristin, McPeters, Leslie, Riggsbee, Christina, Rixey, Lucy, Michler, Robert E., DeRose, Joseph J., Jr., Goldstein, Daniel J., Bello, Ricardo A., Taub, Cynthia, Spevack, Daniel, Kirchoff, Kathryn, Meli, Rebecca, Garcia, Juan, Goldenberg, Jon, Kealy, Lauren, Perrault, Louis P., Bouchard, Denis, Tanguay, Jean François, O'Meara, Eileen, Lacharité, Jonathan, Robichaud, Sophie, Horvath, Keith A., Corcoran, Philip C., Siegenthaler, Michael P., Murphy, Mandy, Iraola, Margaret, Greenberg, Ann, Kumkumian, Greg, Milner, Mark, Nadareishvili, Zurab, Whitson, Bryan A., Hasan, Ayesha, McDavid, Asia, Fadorsen, Denise, Ouzounian, Maral, Yau, Terry, Farkouh, Michael, Woo, Anna, Cusimano, Robert James, David, Tirone, Feindel, Christopher, Fumakia, Nishit, Christie, Shakira, Mullen, John C., Bissonauth, Asvina, Hripko, Alexandra, Gammie, James S., Noor, Zahid, Mackowick, Kristen, Deasey, Stephanie, Al-Suqi, Manal, Collins, Julia, Acker, Michael A., Messé, Steven, Kirkpatrick, James, Mayer, Mary Lou, McDonald, Caitlin, Fok, Holley, Maffei, Breanna, Cresse, Stephen, Gepty, Christine, Bowdish, Michael, Starnes, Vaughn A., Shavalle, David, Heck, Christi, Hackmann, Amy, Baker, Craig, Fleischman, Fernando, Cunningham, Mark, Lozano, Edward, Hernandez, Michelle, Ailawadi, Gorav, Kron, Irving L., Johnston, Karen, Ghanta, Ravi K., Dent, John M., Kern, John, Yarboro, Leora, Ragosta, Michael, Annex, Brian, Bergin, Jim, Burks, Sandra, Cosner, Mike, Green, China, Loya, Samantha, Kim, Hye Ryun, Bull, David A., Desvigne-Nickens, Patrice, Dixon, Dennis O., Gottesman, Rebecca, Haigney, Mark, Holubkov, Richard, Iadecola, Constantino, Jacobs, Alice, Meslin, Eric M., Murkin, John M., Spertus, John A., Sellke, Frank, McDonald, Cheryl L., Canty, John, Dickert, Neal, Ikonomidis, John S., Kim, KyungMann, Williams, David O., Yancy, Clyde W., Chaturvedi, Seemant, Chimowitz, Marc, Fang, James C., Richenbacher, Wayne, Rao, Vivek, Furie, Karen L., Miller, Rachel, Cook, Jennifer, D'Alessandro, David, Han, Frederick, Pinney, Sean, Walsh, Mary N., Greer, David, Ishida, Koto, Stapf, Christian, Hung, Judy, Zeng, Xin, Hung, David, Satitthummanid, Sudarat, Billelo, Michel, Davatzikos, Christos, Erus, Guray, Karpf, Lauren, Desiderio, Lisa, Browndyke, Jeffrey N., James, Michael L., Toulgoat-Dubois, Yanne, Brassard, Rachele, Virmanu, Renu, Romero, Maria E., Braumann, Ryan, Messé, Steven R., Mack, Michael J., Southerland, Andrew M., Moy, Claudia Scala, and Bowdish, Michael E.

Published
2024
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35. Long-term follow-up after ultrathin vs. conventional 2nd-generation drug-eluting stents: a systematic review and meta-analysis of randomized controlled trials.

Author

Madhavan, Mahesh, Howard, James, Naqvi, Azim, Ben-Yehuda, Ori, Redfors, Bjorn, Prasad, Megha, Shahim, Bahira, Leon, Martin, Bangalore, Sripal, Stone, Gregg, and Ahmad, Yousif

Subjects
Coronary artery disease, Drug-eluting stents, Meta-analysis, Percutaneous coronary intervention, Ultrathin-strut, Absorbable Implants, Coronary Artery Disease, Drug-Eluting Stents, Follow-Up Studies, Humans, Percutaneous Coronary Intervention, Prosthesis Design, Randomized Controlled Trials as Topic, Treatment Outcome
Abstract

AIMS: Contemporary 2nd-generation thin-strut drug-eluting stents (DES) are considered standard of care for revascularization of patients undergoing percutaneous coronary intervention. A previous meta-analysis of 10 randomized controlled trials (RCTs) with 11 658 patients demonstrated a 16% reduction in the 1-year risk of target lesion failure (TLF) with ultrathin-strut DES compared with conventional 2nd-generation thin-strut DES. Whether this benefit is sustained longer term is not known, and newer trial data may inform these relative outcomes. We therefore sought to perform an updated systematic review and meta-analysis of RCTs comparing clinical outcomes with ultrathin-strut DES (≤70 µm strut thickness) with conventional 2nd-generation thin-strut DES. METHODS AND RESULTS: We performed a random-effects meta-analysis of all RCTs comparing ultrathin-strut DES to conventional 2nd-generation thin-strut DES. The pre-specified primary endpoint was long-term TLF, a composite of cardiac death, myocardial infarction (MI), or clinically driven target lesion revascularization (CD-TLR). Secondary endpoints included the components of TLF, stent thrombosis (ST), and all-cause death. There were 16 eligible trials in which 20 701 patients were randomized. The weighted mean follow-up duration was 2.5 years. Ultrathin-strut DES were associated with a 15% reduction in long-term TLF compared with conventional 2nd-generation thin-strut DES [relative risk (RR) 0.85, 95% confidence interval (CI) 0.76-0.96, P = 0.008] driven by a 25% reduction in CD-TLR (RR 0.75, 95% CI 0.62-0.92, P = 0.005). There were no significant differences between stent types in the risks of MI, ST, cardiac death, or all-cause mortality. CONCLUSIONS: At a mean follow-up of 2.5 years, ultrathin-strut DES reduced the risk of TLF, driven by less CD-TLR compared with conventional 2nd-generation thin-strut DES, with similar risks of MI, ST, cardiac death, and all-cause mortality.

Published
2021

36. 1-Year Outcomes Following Transfemoral Transseptal Transcatheter Mitral Valve Replacement: Intrepid TMVR Early Feasibility Study Results

Author

Zahr, Firas, Song, Howard K., Chadderdon, Scott, Gada, Hemal, Mumtaz, Mubashir, Byrne, Timothy, Kirshner, Merick, Sharma, Samin, Kodali, Susheel, George, Isaac, Merhi, William, Yarboro, Leora, Sorajja, Paul, Bapat, Vinayak, Bajwa, Tanvir, Weiss, Eric, Thaden, Jeremy J., Gearhart, Elizabeth, Lim, Scott, Reardon, Michael, Adams, David, Mack, Michael, and Leon, Martin B.

Published
2023
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37. Long-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 Trial

Author

Bhatt, Deepak L, Bakris, George, Cohen, Sidney A, D'Agostino, Ralph, Esler, Murray, Flack, John, Kandzari, David E, Katzen, Barry, Leon, Martin, Mauri, Laura, Negoita, Manuela, Oparil, Suzanne, Rocha-Singh, Krishna, Townsend, Ray, Abbud, Ziad, Addo, Tayo, Anderson, David, Angle, John, Aronow, Herbert, Babaev, Anvar, Benzuly, Keith, Brar, Somjot, Brown, David, Calhoun, David, Casale, Paul, Chaffer, Sheldon, Choi, James, Chung, Eugene, Cohen, Debbie L, Creager, Mark, Dangas, George, Dauerman, Harold, David, Shukri, Davies, Mark, de Marchena, Eduardo, Denktas, Ali E, Devireddy, Chandan, Downey, William, Dunlap, Mark, Fisher, Daniel, Ghali, Magdi, Gnall, Eric, Gollapudi, Raghava, Goodwin, Mark, Goswami, Nilesh, Gruberg, Luis, Gulati, Rajiv, Gupta, Anuj, Gupta, Anjan, Gurm, Hitinder, Hastings, Jeffrey, Kinlay, Scott, Kipperman, Robert, Buchbinder, Maurice, Kirtane, Ajay, Kovach, Richard, Lee, David, Mann, Samuel, Marso, Steven, Matar, Fadi, Mazzaferri, Ernest, Mandelsohn, Farrel, Moussa, Issam, Murphy, Timothy, Nathan, Sandeep, Negus, Brian, Parikh, Sahil, Patel, Manesh, Patel, Kirikumar, Paulus, Basil, Petrossian, George, Powell, Alex, Preibisz, Jacek, Rader, Florian, Randall, Otelio, Razavi, Mahmood, Reilly, John, Reiner, Jonathan, Ring, Michael, Robbins, Mark, Rogers, Kevin, Ruggiero, Nicolas, Santos, Renato, Little, William, Schindler, John, Scott, Thomas, Shimshak, Thomas, Shishehbor, Mehdi, Silver, Mitchel, Singh, Jasvindar, Singh, Kanwar, Slovut, David, Stoufer, Rick G, Teirsten, Paul, Todoran, Thomas, Vetrovec, George, Waksman, Ron, Wang, Yale, Waxman, Sergio, Wilkins, Robert, Ziada, Khaled, Zidar, Frank, Vaduganathan, Muthiah, Leon, Martin B, Townsend, Raymond R, Katzen, Barry T, Brar, Sandeep, DeBruin, Vanessa, Fahy, Martin, and Bakris, George L

Published
2022
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38. The Mortality Burden of Untreated Aortic Stenosis

Author

Généreux, Philippe, Sharma, Rahul P., Cubeddu, Robert J., Aaron, Lucy, Abdelfattah, Omar M., Koulogiannis, Konstantinos P., Marcoff, Leo, Naguib, Mostafa, Kapadia, Samir R., Makkar, Rajendra R., Thourani, Vinod H., van Boxtel, Benjamin S., Cohen, David J., Dobbles, Michael, Barnhart, Glenn R., Kwon, Michelle, Pibarot, Philippe, Leon, Martin B., and Gillam, Linda D.

Published
2023
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42. Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints

Author

Arnold, Suzanne, Bapat, Vinayak, Berry, Natalia, Blanke, Philipp, Burkhoff, Daniel, Coylewright, Megan, Duggal, Neal, Galper, Benjamin, George, Isaac, Guerrero, Mayra, Hamid, Nadira, Jagadeesan, Vikrant, Kodali, Susheel, Krucoff, Mitch, Lang, Roberto, Madhavan, Mahesh, McLaughin, Vallerie, Mehran, Roxana, Philippon, Francois, Sethi, Sanjum S., Simonato, Matheus, Smith, Robert, Sodhi, Nishtha, Spertus, John, Stocker, Thomas J., Stone, Gregg, Hahn, Rebecca T., Lawlor, Matthew K., Davidson, Charles J., Badhwar, Vinay, Sannino, Anna, Spitzer, Ernest, Lurz, Philipp, Lindman, Brian R., Topilsky, Yan, Baron, Suzanne J., Chadderdon, Scott, Khalique, Omar K., Tang, Gilbert H.L., Taramasso, Maurizio, Grayburn, Paul A., Badano, Luigi, Leipsic, Jonathon, Lindenfeld, JoAnn, Windecker, Stephan, Vemulapalli, Sreekanth, Redfors, Bjorn, Alu, Maria C., Cohen, David J., Rodés-Cabau, Josep, Ailawadi, Gorav, Mack, Michael, Ben-Yehuda, Ori, Leon, Martin B., and Hausleiter, Jörg

Published
2023
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44. Atrial Fibrillation Burden and Atrial Shunt Therapy in Heart Failure With Preserved Ejection Fraction

Author

Patel, Ravi B., Reddy, Vivek Y., Komtebedde, Jan, Wegerich, Stephan W., Sekaric, Jadranka, Swarup, Vijay, Walton, Antony, Laurent, Gabriel, Chetcuti, Stanley, Rademann, Matthias, Bergmann, Martin, McKenzie, Scott, Bugger, Heiko, Bruno, Raphael Romano, Herrmann, Howard C., Nair, Ajith, Gupta, Deepak K., Lim, Scott, Kapadia, Samir, Gordon, Robert, Vanderheyden, Marc, Noel, Thomas, Bailey, Steven, Gertz, Zachary M., Trochu, Jean-Noël, Cutlip, Donald E., Leon, Martin B., Solomon, Scott D., van Veldhuisen, Dirk J., Auricchio, Angelo, and Shah, Sanjiv J.

Published
2023
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45. Rationale and design of a randomized study comparing the Watchman FLX device to DOACs in patients with atrial fibrillation

Author

Kar, Saibal, Doshi, Shephal K., Alkhouli, Mohamad, Camm, A. John, Coylewright, Megan, Gibson, Michael C., Granger, Christopher B., Gurol, Mahmut E., Huber, Kenneth, Mansour, Moussa, Nair, Devi G., Natale, Andrea, Pocock, Stuart J., Reddy, Vivek R., Saliba, Walid, Christen, Thomas, Allocco, Dominic J., Ellenbogen, Kenneth A., and Leon, Martin B.

Published
2023
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46. Diagnosis, Classification, and Management Strategies for Mitral Annular Calcification: A Heart Valve Collaboratory Position Statement

Author

Guerrero, Mayra E., Grayburn, Paul, Smith, Robert L., II, Sorajja, Paul, Wang, Dee Dee, Ahmad, Yousif, Blusztein, David, Cavalcante, João, Tang, Gilbert H.L., Ailawadi, Gorav, Lim, D. Scott, Blanke, Philipp, Eleid, Mackram F., Kaneko, Tsuyoshi, Thourani, Vinod H., Bapat, Vinayak, Mack, Michael J., Leon, Martin B., and George, Isaac

Published
2023
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48. 5-Year Prospective Evaluation of Mitral Valve-in-Valve, Valve-in-Ring, and Valve-in-MAC Outcomes: MITRAL Trial Final Results

Author

Guerrero, Mayra E., Eleid, Mackram F., Wang, Dee Dee, Pursnani, Amit, Kodali, Susheel K., George, Isaac, Palacios, Igor, Russell, Hyde, Makkar, Raj R., Kar, Saibal, Satler, Lowell F., Rajagopal, Vivek, Dangas, George, Tang, Gilbert H.L., McCabe, James M., Whisenant, Brian K., Fang, Kenith, Balan, Prakash, Smalling, Richard, Kaptzan, Tatiana, Lewis, Bradley, Douglas, Pamela S., Hahn, Rebecca T., Thaden, Jeremy, Oh, Jae K., Leon, Martin, O’Neill, William, and Rihal, Charanjit

Published
2023
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49. Transcatheter aortic valve implantation in patients with bicuspid valve morphology: a roadmap towards standardization

Author

Xiong, Tian-Yuan, Ali, Walid Ben, Feng, Yuan, Hayashida, Kentaro, Jilaihawi, Hasan, Latib, Azeem, Lee, Michael Kang-Yin, Leon, Martin B., Makkar, Raj R., Modine, Thomas, Naber, Christoph, Peng, Yong, Piazza, Nicolo, Reardon, Michael J., Redwood, Simon, Seth, Ashok, Sondergaard, Lars, Tay, Edgar, Tchetche, Didier, Yin, Wei-Hsian, Chen, Mao, Prendergast, Bernard, and Mylotte, Darren

Published
2023
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