39 results on '"Leombroni, Martina"'
Search Results
2. Fetal midline anomalies: Diagnosis and counselling part 2: Septal anomalies
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Leombroni, Martina, Khalil, Asma, Liberati, Marco, and D'Antonio, Francesco
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- 2018
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3. Fetal midline anomalies: Diagnosis and counselling Part 1: Corpus callosum anomalies
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Leombroni, Martina, Khalil, Asma, Liberati, Marco, and D'Antonio, Francesco
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- 2018
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4. Clinical and ultrasound characteristics of vaginal lesions
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Pozzati, Federica, Moro, Francesca, Leombroni, Martina, Bertoldo, Valentina, Trivellizzi, Nausica, Mascilini, Floriana, Bolomini, Giulia, Ciccarone, Francesca, Garganese, Giorgia, Scambia, Giovanni, and Testa, Antonia Carla
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- 2021
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5. Incidental Finding of an Ovarian Carcinoid on 11C-Methionine PET/CT
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Maccora, Daria, Caldarella, Carmelo, Leombroni, Martina, De Stefano, Valerio, and Leccisotti, Lucia
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- 2020
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6. Ultrasound features and clinical outcome of patients with malignant ovarian masses diagnosed during pregnancy: experience of a gynecological oncology ultrasound center
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Moro, Francesca, Mascilini, Floriana, Pasciuto, Tina, Leombroni, Martina, Li Destri, Marta, De Blasis, Ilaria, Garofalo, Serafina, Scambia, Giovanni, and Testa, Antonia Carla
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- 2019
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7. Management of Unusual Not Scar Ectopic Pregnancy: A Multicentre Retrospective Case Series
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Ferrari, Federico, primary, Ficarelli, Silvia, additional, Cornelli, Benedetta, additional, Ferrari, Filippo Alberto, additional, Farulla, Antonino, additional, Alboni, Carlo, additional, Fontana, Enrico, additional, Roccio, Marianna, additional, Boschi, Anna Chiara, additional, Buca, Danilo, additional, Leombroni, Martina, additional, Peterlunger, Isabel, additional, Moruzzi, Maria Cristina, additional, Beneduce, Giuliana, additional, Bolomini, Giulia, additional, Laganà, Antonio Simone, additional, Malorgio, Piero, additional, Ricci, Giuseppe, additional, Franchi, Massimo, additional, Scambia, Giovanni, additional, Sartori, Enrico, additional, and Odicino, Franco, additional
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- 2022
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8. Reproductive and pregnancy outcomes of fertility-sparing treatments for early-stage endometrial cancer or atypical hyperplasia: A systematic review and meta-analysis
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De Rocco, Silvia, primary, Buca, Danilo, additional, Oronzii, Ludovica, additional, Petrillo, Marco, additional, Fanfani, Francesco, additional, Nappi, Luigi, additional, Liberati, Marco, additional, D'Antonio, Francesco, additional, Scambia, Giovanni, additional, Leombroni, Martina, additional, Dessole, Margherita, additional, and Lucidi, Alessandro, additional
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- 2022
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9. Clinical and ultrasound characteristics of vaginal lesions
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Pozzati, Federica, primary, Moro, Francesca, additional, Leombroni, Martina, additional, Bertoldo, Valentina, additional, Trivellizzi, Nausica, additional, Mascilini, Floriana, additional, Bolomini, Giulia, additional, Ciccarone, Francesca, additional, Garganese, Giorgia, additional, Scambia, Giovanni, additional, and Testa, Antonia Carla, additional
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- 2020
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10. Role of Extracellular Vesicles in Epithelial Ovarian Cancer: A Systematic Review
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Lucidi, Alessandro, primary, Buca, Danilo, additional, Ronsini, Carlo, additional, Tinari, Sara, additional, Bologna, Giuseppina, additional, Buca, Davide, additional, Leombroni, Martina, additional, Liberati, Marco, additional, D’Antonio, Francesco, additional, Scambia, Giovanni, additional, Lanuti, Paola, additional, and Petrillo, Marco, additional
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- 2020
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11. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19
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Di Mascio, Daniele, primary, Sen, Cihat, additional, Saccone, Gabriele, additional, Galindo, Alberto, additional, Grünebaum, Amos, additional, Yoshimatsu, Jun, additional, Stanojevic, Milan, additional, Kurjak, Asım, additional, Chervenak, Frank, additional, Rodríguez Suárez, María José, additional, Gambacorti-Passerini, Zita Maria, additional, Baz, María de los Angeles Anaya, additional, Aguilar Galán, Esther Vanessa, additional, López, Yolanda Cuñarro, additional, De León Luis, Juan Antonio, additional, Hernández, Ignacio Cueto, additional, Herraiz, Ignacio, additional, Villalain, Cecilia, additional, Venturella, Roberta, additional, Rizzo, Giuseppe, additional, Mappa, Ilenia, additional, Gerosolima, Giovanni, additional, Hellmeyer, Lars, additional, Königbauer, Josefine, additional, Ameli, Giada, additional, Frusca, Tiziana, additional, Volpe, Nicola, additional, Luca Schera, Giovanni Battista, additional, Fieni, Stefania, additional, Esposito, Eutalia, additional, Simonazzi, Giuliana, additional, Di Donna, Gaetana, additional, Youssef, Aly, additional, Della Gatta, Anna Nunzia, additional, Di Donna, Mariano Catello, additional, Chiantera, Vito, additional, Buono, Natalina, additional, Sozzi, Giulio, additional, Greco, Pantaleo, additional, Morano, Danila, additional, Bianchi, Beatrice, additional, Lombana Marino, Maria Giulia, additional, Laraud, Federica, additional, Ramone, Arianna, additional, Cagnacci, Angelo, additional, Barra, Fabio, additional, Gustavino, Claudio, additional, Ferrero, Simone, additional, Ghezzi, Fabio, additional, Cromi, Antonella, additional, Laganà, Antonio Simone, additional, Laurita Longo, Valentina, additional, Stollagli, Francesca, additional, Sirico, Angelo, additional, Lanzone, Antonio, additional, Driul, Lorenza, additional, Cecchini D, Fabiana, additional, Xodo, Serena, additional, Rodriguez, Brian, additional, Mercado-Olivares, Felipe, additional, Elkafrawi, Deena, additional, Sisti, Giovanni, additional, Esposito, Rosanna, additional, Coviello, Antonio, additional, Cerbone, Marco, additional, Morlando, Maddalena, additional, Schiattarella, Antonio, additional, Colacurci, Nicola, additional, De Franciscis, Pasquale, additional, Cataneo, Ilaria, additional, Lenzi, Marinella, additional, Sandri, Fabrizio, additional, Buscemi, Riccardo, additional, Gattei, Giorgia, additional, Sala, Francesca della, additional, Valori, Eleonora, additional, Rovellotti, Maria Cristina, additional, Done, Elisa, additional, Faron, Gilles, additional, Gucciardo, Leonardo, additional, Esposito, Valentina, additional, Vena, Flaminia, additional, Giancotti, Antonella, additional, Brunelli, Roberto, additional, Muzii, Ludovico, additional, Nappi, Luigi, additional, Sorrentino, Felice, additional, Vasciaveo, Lorenzo, additional, Liberati, Marco, additional, Buca, Danilo, additional, Leombroni, Martina, additional, Di Sebastiano, Francesca, additional, Di Tizio, Luciano, additional, Gazzolo, Diego, additional, Franchi, Massimo, additional, Ianniciello, Quintino Cesare, additional, Garzon, Simone, additional, Petriglia, Giuliano, additional, Borrello, Leonardo, additional, Nieto-Calvache, Albaro Josè, additional, Burgos-Luna, Juan Manuel, additional, Kadji, Caroline, additional, Carlin, Andrew, additional, Bevilacqua, Elisa, additional, Moucho, Marina, additional, Pinto, Pedro Viana, additional, Figueiredo, Rita, additional, Morales Roselló, José, additional, Loscalzo, Gabriela, additional, Martinez-Varea, Alicia, additional, Diago, Vincente, additional, Jimenez Lopez, Jesús S, additional, Aykanat, Alicia Yeliz, additional, Cosma, Stefano, additional, Carosso, Andrea, additional, Benedetto, Chiara, additional, Bermejo, Amanda, additional, May Feuerschuette, Otto Henrique, additional, Uyaniklar, Ozlem, additional, Ocakouglu, Sakine Rahimli, additional, Atak, Zeliha, additional, Gündüz, Reyhan, additional, Haberal, Esra Tustas, additional, Froessler, Bernd, additional, Parange, Anupam, additional, Palm, Peter, additional, Samardjiski, Igor, additional, Taccaliti, Chiara, additional, Okuyan, Erhan, additional, Daskalakis, George, additional, Moreira de Sa, Renato Augusto, additional, Pittaro, Alejandro, additional, Gonzalez-Duran, Maria Luisa, additional, Guisan, Ana Concheiro, additional, Genç, Şerife Özlem, additional, Zlatohlávková, Blanka, additional, Piqueras, Anna Luengo, additional, Oliva, Dolores Esteban, additional, Cil, Aylin Pelin, additional, Api, Olus, additional, Antsaklis, Panos, additional, Ples, Liana, additional, Kyvernitakis, Ioannis, additional, Maul, Holger, additional, Malan, Marcel, additional, Lila, Albert, additional, Granese, Roberta, additional, Ercoli, Alfredo, additional, Zoccali, Giuseppe, additional, Villasco, Andrea, additional, Biglia, Nicoletta, additional, Madalina, Ciuhodaru, additional, Costa, Elena, additional, Daelemans, Caroline, additional, Pintiaux, Axelle, additional, Cueto, Elisa, additional, Hadar, Eran, additional, Dollinger, Sarah, additional, Brzezinski Sinai, Noa A., additional, Huertas, Erasmo, additional, Arango, Pedro, additional, Sanchez, Amadeo, additional, Schvartzman, Javier Alfonso, additional, Cojocaru, Liviu, additional, Turan, Sifa, additional, Turan, Ozhan, additional, Di Dedda, Maria Carmela, additional, Molpeceres, Rebeca Garrote, additional, Zdjelar, Snezana, additional, Premru-Srsen, Tanja, additional, Cerar, Lilijana Kornhauser, additional, Druškovič, Mirjam, additional, De Robertis, Valentina, additional, Stefanovic, Vedran, additional, Nupponen, Irmeli, additional, Nelskylä, Kaisa, additional, Khodjaeva, Zulfiya, additional, Gorina, Ksenia A., additional, Sukhikh, Gennady T., additional, Maruotti, Giuseppe Maria, additional, Visentin, Silvia, additional, Cosmi, Erich, additional, Ferrari, Jacopo, additional, Gatti, Alessandra, additional, Luvero, Daniela, additional, Angioli, Roberto, additional, Puri, Ludovica, additional, Palumbo, Marco, additional, D’Urso, Giusella, additional, Colaleo, Francesco, additional, Chiara Rapisarda, Agnese Maria, additional, Carbone, Ilma Floriana, additional, Mollo, Antonio, additional, Nazzaro, Giovanni, additional, Locci, Mariavittoria, additional, Guida, Maurizio, additional, Di Spiezio Sardo, Attilio, additional, Panici, Pierluigi Benedetti, additional, Berghella, Vincenzo, additional, Flacco, Maria Elena, additional, Manzoli, Lamberto, additional, Bifulco, Giuseppe, additional, Scambia, Giovanni, additional, Zullo, Fulvio, additional, and D’Antonio, Francesco, additional
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- 2020
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12. Diagnostic Accuracy of Doppler Ultrasound in Predicting Perinatal Outcome in Appropriate for Gestational Age Fetuses: A Prospective Study
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Buca, Danilo, additional, Rizzo, Giuseppe, additional, Gustapane, Sarah, additional, Mappa, Ilenia, additional, Leombroni, Martina, additional, Bascietto, Francesca, additional, Flacco, Maria Elena, additional, Acuti Martellucci, Cecilia, additional, Manzoli, Lamberto, additional, Nappi, Luigi, additional, Familiari, Alessandra, additional, Scambia, Giovanni, additional, Liberati, Marco, additional, and D'Antonio, Francesco, additional
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- 2020
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13. Ultrasound Imaging in Endometriosis
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Moro, Francesca, primary, Leombroni, Martina, additional, and Testa, Antonia Carla, additional
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- 2019
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14. Diagnostic Accuracy of Doppler Ultrasound in Predicting Perinatal Outcome in Appropriate for Gestational Age Fetuses: A Prospective Study.
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Buca, Danilo, Rizzo, Giuseppe, Gustapane, Sarah, Mappa, Ilenia, Leombroni, Martina, Bascietto, Francesca, Flacco, Maria Elena, Acuti Martellucci, Cecilia, Manzoli, Lamberto, Nappi, Luigi, Familiari, Alessandra, Scambia, Giovanni, Liberati, Marco, and D'Antonio, Francesco
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- 2021
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15. Post-partum pelvic floor dysfunction assessed on 3D rotational ultrasound: a prospective study on women with first- and second-degree perineal tears and episiotomy
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Leombroni, Martina, primary, Buca, Danilo, additional, Liberati, Marco, additional, Falò, Eleonora, additional, Rizzo, Giuseppe, additional, Khalil, Asma, additional, Manzoli, Lamberto, additional, Flacco, Maria Elena, additional, Santarelli, Alessandro, additional, Makatsariya, Alexander, additional, Frondaroli, Franco, additional, and D’Antonio, Francesco, additional
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- 2019
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16. Post-partum pelvic floor dysfunction assessed on 3D rotational ultrasound: a prospective study on women with first- and second-degree perineal tears and episiotomy.
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Leombroni, Martina, Buca, Danilo, Liberati, Marco, Falò, Eleonora, Rizzo, Giuseppe, Khalil, Asma, Manzoli, Lamberto, Flacco, Maria Elena, Santarelli, Alessandro, Makatsariya, Alexander, Frondaroli, Franco, and D'Antonio, Francesco
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PELVIC floor disorders , *EPISIOTOMY , *LONGITUDINAL method , *ANUS , *LABOR pain (Obstetrics) , *MENISCUS injuries , *MUSCLES , *MUSCLE injuries , *PUERPERIUM , *LABOR complications (Obstetrics) , *WOUNDS & injuries , *DELIVERY (Obstetrics) , *PERINEUM ,PELVIC floor injuries - Abstract
Purpose: To evaluate the morphology and biometry of pelvic floor structures 3 months after birth in women experiencing first- or second-degree perineal tears or undergoing episiotomy during labor.Material and methods: Prospective observational study including nulliparous women delivering at term with a clinical diagnosis of first- or second-degree perineal tears after birth or undergoing episiotomy. The role of Kristeller maneuver during labor in affecting pelvic structure and function is also explored. All women underwent 2D trans-perineal and 3D endovaginal or endoanal ultrasound 3 months after birth.Results: 115 women assessed 3 months after delivery were enrolled in the study. Compared with controls, women who experienced first-degree perineal tears had higher bladder neck-symphysis (versus 20.9 ± 4.9 versus 16.1 ± 4.9 mm, p = .017), bladder wall-pubic symphysis (22.4 ± 7.4 versus 14.2 ± 9.5 mm, p = .02) and anorectal angle-symphysis distance (12.5 ± 4.7 versus 9.3 ± 4.3 mm, p = .018). Furthermore, they have thicker internal and external anal sphincter. The incidence of partial right and left pubo-rectalis muscle avulsion was higher in women experiencing first-degree vaginal tear during labor (16.2 versus 0%, p = .004 for both). In women affected by second-degree tears, the occurrence of partial avulsion of the right and left pubo-rectalis muscle was 16.2%, while Oasis was detected in 10.8% of the cases. Women receiving Kristeller maneuver during labor had a higher incidence of either right or left puborectalis muscle avulsion.Conclusion: Women who had either first- and second-degree perineal tears or episiotomy show signs of abnormal pelvic morphometry on 3D rotational ultrasound 3 months after birth. [ABSTRACT FROM AUTHOR]
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- 2021
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17. Risk factors for abnormally invasive placenta: a systematic review and meta-analysis.
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Iacovelli, Antonia, Liberati, Marco, Khalil, Asma, Timor-Trisch, Ilan, Leombroni, Martina, Buca, Danilo, Milani, Michela, Flacco, Maria Elena, Manzoli, Lamberto, Fanfani, Francesco, Calì, Giuseppe, Familiari, Alessandra, Scambia, Giovanni, and D'Antonio, Francesco
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PLACENTA praevia ,META-analysis ,PLACENTA ,FERTILIZATION in vitro ,CESAREAN section ,MATERNAL age ,UTERINE surgery ,RESEARCH ,RESEARCH methodology ,SYSTEMATIC reviews ,EVALUATION research ,MEDICAL cooperation ,PLACENTA accreta ,COMPARATIVE studies - Abstract
Purpose of the article. To explore the strength of association between different maternal and pregnancy characteristics and the occurrence of abnormally invasive placenta (AIP).Materials and methods: Pubmed, Embase, CINAHL databases were searched. The risk factors for AIP explored were: obesity, age >35 years, smoking before or during pregnancy, placenta previa, prior cesarean section (CS), placenta previa and prior CS, prior uterine surgery, abortion and uterine curettage, in vitro fertilization (IVF) pregnancy and interval between a previous CS, and a subsequent pregnancy. Random-effect head-to-head meta-analyses were used to analyze the data.Results: Forty-six were included in the systematic review. Maternal obesity (Odd ratio, OR: 1.4, 95% CI 1.0-1.8), advanced maternal age (OR: 3.1, 95% CI 1.4-7.0) and parity (OR: 2.5, 95% CI 1.7-3.6), but not smoking were associated with a higher risk of AIP. The presence of placenta previa in women with at least a prior CS was associated with a higher risk of AIP compared to controls, with an OR of 12.0, 95% CI 1.6-88.0. Furthermore, the risk of AIP increased with the number of prior CS (OR of 2.6, 95% CI 1.6-4.4 and 5.4, 95% CI 1.7-17.4 for two and three prior CS respectively). Finally, IVF pregnancies were associated with a high risk of AIP, with an OR of 2.8 (95% CI 1.2-6.8).Conclusion: A prior CS and placenta previa are among the strongest risk factors for the occurrence of AIP. [ABSTRACT FROM AUTHOR]
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- 2020
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18. Corticosteroid prophylaxis for fetal immaturity in a pregnant patient with atrial myxoma
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Di Giammarco, Gabriele, Marchetti, Marziale, Foschi, Massimiliano, Marinelli, Daniele, Micucci, Donato, Buca, Danilo, Leombroni, Martina, and Di Mauro, Michele
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- 2016
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19. Risk factors for abnormally invasive placenta: a systematic review and meta-analysis
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Iacovelli, Antonia, primary, Liberati, Marco, additional, Khalil, Asma, additional, Timor-Trisch, Ilan, additional, Leombroni, Martina, additional, Buca, Danilo, additional, Milani, Michela, additional, Flacco, Maria Elena, additional, Manzoli, Lamberto, additional, Fanfani, Francesco, additional, Calì, Giuseppe, additional, Familiari, Alessandra, additional, Scambia, Giovanni, additional, and D’Antonio, Francesco, additional
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- 2018
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20. ossypiboma: Ultrasound Diagnosis and Laparoscopic Management
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Restaino, Stefano, primary, Ferrandina, G., additional, Finelli, Angelo, additional, Testa, Antonia, additional, Leombroni, Martina, additional, Scambia, Giovanni, additional, and Fanfani, Francesco, additional
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- 2018
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21. Long-term outcome after surgical repair of pelvic organ prolapse with Elevate Prolapse Repair System
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Buca, Danilo Italo Pio, primary, Liberati, Marco, additional, Falò, Eleonora, additional, Leombroni, Martina, additional, Di Giminiani, Maria, additional, Di Nicola, Marta, additional, Santarelli, Alessandro, additional, Frondaroli, Franco, additional, and Fanfani, Francesco, additional
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- 2018
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22. Role of interventional radiology in pregnancy complicated by placenta accreta spectrum disorder: systematic review and meta-analysis.
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D'Antonio, F., Iacovelli, A., Liberati, M., Leombroni, M., Murgano, D., Cali, G., Khalil, A., Flacco, M. E., Scutiero, G., Iannone, P., Scambia, G., Manzoli, L., Greco, P., D'Antonio, Francesco, Iacovelli, Antonia, Liberati, Marco, Leombroni, Martina, Murgano, Daniela, Cali, Giuseppe, and Khalil, Asma
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INTERVENTIONAL radiology ,META-analysis ,BLOOD loss estimation ,DISSEMINATED intravascular coagulation ,PLACENTA ,ERYTHROCYTES ,SYSTEMATIC reviews ,PLACENTA accreta ,FETAL ultrasonic imaging ,MEDICAL specialties & specialists - Abstract
Objective: To evaluate the potential benefit of interventional radiology (IR) in improving the outcome of women undergoing surgery for a placenta accreta spectrum (PAS) disorder.Methods: MEDLINE, EMBASE and CINAHL databases were searched for studies comparing outcomes of women with a prenatal diagnosis of PAS who underwent an IR procedure before surgery vs those who did not, using a robust collection of terms relating to PAS. The primary outcome was intraoperative estimated blood loss (EBL). Secondary outcomes were the number of transfused units of packed red blood cells (PRBC), fresh frozen plasma (FFP), platelets and cryoprecipitate, operation time, length of hospital stay, EBL ≥ 2.5 L, PRBC transfused ≥ 5 units, surgical complications, bladder or ureteral injury, relaparotomy, infection, disseminated intravascular coagulation, and complications related to endovascular catheter placement. Only studies reporting on the incidence of, or the mean difference in, the observed outcomes in women affected by a PAS disorder who had vs those who did not have an IR procedure before surgery were considered for inclusion. All outcomes were explored in the overall population of women with a prenatally diagnosed PAS disorder and in those undergoing hysterectomy. Quality assessment of each included study was performed using the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool. The GRADE methodology was used to assess the quality of the body of retrieved evidence.Results: Fifteen studies (958 women with PAS) were included. In women who underwent IR before surgery, compared with those who did not, mean EBL (mean difference (MD), -1.02 L; 95% CI, -1.60 to -0.43 L; P < 0.001) and the risk of EBL ≥ 2.5 L (odds ratio (OR), 0.18; 95% CI, 0.04-0.78; P = 0.02) were significantly lower. There was no significant difference between the two groups in the other outcomes explored. On subgroup analysis of pregnancies complicated by PAS undergoing hysterectomy, EBL (MD, -0.68 L; 95% CI, -1.24 to -0.12 L; P = 0.02) and the number of transfused FFP units (MD, -1.66; 95% CI, -2.71 to -0.61; P = 0.02) were significantly lower in women who had an endovascular IR procedure compared with controls. Furthermore, women undergoing IR had a significantly lower risk of EBL ≥ 2.5 L (OR, 0.10; 95% CI, 0.02-0.47; P = 0.004). Overall, complications related to the placement of an endovascular catheter occurred in 5.3% (95% CI, 2.6-8.9; I2 , 65.3%) of pregnancies undergoing IR. Overall quality of evidence, as assessed by GRADE, was very low.Conclusions: The current available data provide encouraging evidence that IR procedures may be associated with lower EBL and need for transfusion in pregnancies undergoing surgery for a PAS disorder. However, given the overall very low quality of the evidence, further large studies are needed in order to confirm the beneficial role of IR in improving the outcome of these women. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]- Published
- 2019
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23. Outcome of fetal gastro‐intestinal cysts: a systematic review and meta‐analysis
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Marrone, Luisa, primary, Liberati, Marco, additional, Khalil, Asma, additional, Rizzo, Giuseppe, additional, Leombroni, Martina, additional, Buca, Danilo, additional, Bascietto, Francesca, additional, Gustapane, Sarah, additional, Flacco, Maria Elena, additional, Manzoli, Lamberto, additional, Acharya, Ganesh, additional, and D'Antonio, Francesco, additional
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- 2016
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24. Outcomes Associated With Isolated Agenesis of the Corpus Callosum: A Meta-analysis
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D’Antonio, Francesco, primary, Pagani, Giorgio, additional, Familiari, Alessandra, additional, Khalil, Asma, additional, Sagies, Tally-Lerman, additional, Malinger, Gustavo, additional, Leibovitz, Zvi, additional, Garel, Catherine, additional, Moutard, Marie Laure, additional, Pilu, Gianluigi, additional, Bhide, Amar, additional, Acharya, Ganesh, additional, Leombroni, Martina, additional, Manzoli, Lamberto, additional, Papageorghiou, Aris, additional, and Prefumo, Federico, additional
- Published
- 2016
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25. Peritonitis due to a foreign vaginal body: A case report
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Buca, Danilo Italo Pio, primary, Di Tizio, Luciano, additional, Ianieri, Manuel Maria, additional, Murgano, Daniela, additional, Leombroni, Martina, additional, and Liberati, Marco, additional
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- 2016
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26. A 2-Year Evaluation of Quality of Life Outcomes of Patients With Pelvic Organ Prolapse Treated With an Elevate Prolapse Repair System
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Buca, Danilo Italo Pio, primary, Leombroni, Martina, additional, Falò, Eleonora, additional, Bruno, Matteo, additional, Santarelli, Alessandro, additional, Frondaroli, Franco, additional, Liberati, Marco, additional, and Fanfani, Francesco, additional
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- 2016
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27. Parasitic Myomas Diagnosed During Pregnancy
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Di Tizio, Luciano, primary, Buca, Danilo Italo Pio, additional, Murgano, Daniela, additional, Iannantuono, Carolina, additional, Leombroni, Martina, additional, Ianieri, Manuel Maria, additional, and Liberati, Marco, additional
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- 2014
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28. A 2-Year Evaluation of Quality of Life Outcomes of Patients With Pelvic Organ Prolapse Treated With an Elevate Prolapse Repair System.
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Pio Buca, Danilo Italo, Leombroni, Martina, Falò, Eleonora, Bruno, Matteo, Santarelli, Alessandro, Frondaroli, Franco, Liberati, Marco, and Fanfani, Francesco
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- 2016
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29. Outcomes Associated With Isolated Agenesis of the Corpus Callosum: A Meta-analysis.
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D'Antonio, Francesco, Pagani, Giorgio, Familiari, Alessandra, Khalil, Asma, Sagies, Tally-Lerman, Malinger, Gustavo, Leibovitz, Zvi, Garel, Catherine, Moutard, Marie Laure, Pilu, Gianluigi, Bhide, Amar, Acharya, Ganesh, Leombroni, Martina, Manzoli, Lamberto, Papageorghiou, Aris, and Prefumo, Federico
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- 2016
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30. Diagnostic accuracy of ultrasound in predicting birth-weight discordance in twin pregnancy: systematic review and meta-analysis.
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Leombroni, Martina, Liberati, Marco, Fanfani, Francesco, Pagani, Giorgio, Familiari, Alessandra, Scala, Carolina, Buca, Danilo, Manzoli, Lamberto, Scambia, Giovanni, Rizzo, Giuseppe, D'Antonio, Francesco, Leombroni, M, Liberati, M, Fanfani, F, Pagani, G, Familiari, A, Buca, D, Manzoli, L, Scambia, G, and Rizzo, G
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BIRTH weight , *BODY weight , *FETAL ultrasonic imaging , *META-analysis , *MULTIPLE pregnancy , *PRENATAL care , *TWINS , *FETAL development , *PREDICTIVE tests - Abstract
Objective: To investigate the diagnostic performance of ultrasound in predicting birth-weight (BW) discordance in twin pregnancy.Methods: Electronic databases PubMed, EMBASE and CINAHL were searched using combinations of MeSH terms 'birth weight', 'discordance', 'twins' and 'ultrasound'. Summary estimates of sensitivity, specificity, positive and negative likelihood ratios and diagnostic odds ratios for the predictive accuracy of sonographically estimated fetal-weight (EFW) discordance and abdominal-circumference (AC) discordance in predicting BW discordance were computed using hierarchical summary receiver-operating characteristics curves.Results: Twenty studies (including 5826 twin pregnancies) were included. EFW discordance ≥ 20% had a sensitivity of 65.4% and specificity of 90.8% in predicting BW discordance ≥ 20%. The predictive performance of ultrasound performed within 1 month, 2 weeks and 3 days before birth was 61.4%, 72.3% and 78.9%, respectively. EFW discordance ≥ 25% had a sensitivity of 57.7% and specificity of 95.2% in predicting BW discordance ≥ 25%. The sensitivity of EFW discordance ≥ 25% detected within 1 month, 2 weeks and 3 days before birth was 60.0%, 75.0% and 60.3%, respectively, while the corresponding values for specificity were 97.7%, 96.2% and 87.3%, respectively. In view of the different cut-offs reported among studies, it was not possible to perform comprehensive data synthesis for each AC discordance cut-off. The optimal diagnostic performance of AC discordance was for prediction of BW discordance ≥ 25%, with a sensitivity of 70.8% and specificity of 86.4%.Conclusion: Ultrasound EFW discordance has an overall moderate accuracy in predicting BW discordance in twin pregnancy. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]- Published
- 2016
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31. Role of interventional radiology in pregnancy complicated by placenta accreta spectrum disorder: systematic review and meta‐analysis
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Francesco D'Antonio, Antonia Iacovelli, Maria Elena Flacco, Asma Khalil, Marco Liberati, Giuseppe Calì, Pantaleo Greco, Gennaro Scutiero, Piergiorgio Iannone, Daniela Murgano, Lamberto Manzoli, Martina Leombroni, Giovanni Scambia, D'Antonio, Francesco, Iacovelli, Antonia, Liberati, Marco, Leombroni, Martina, Murgano, Daniela, Cali, Giuseppe, Khalil, Asma, Flacco, Maria Elena, Scutiero, Gennaro, Iannone, Piergiorgio, Scambia, Giovanni, Manzoli, Lamberto, and Greco, Pantaleo
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medicine.medical_specialty ,Placenta accreta ,medicine.medical_treatment ,Population ,Socio-culturale ,increta ,Placenta Accreta ,Radiology, Interventional ,Lower risk ,Ultrasonography, Prenatal ,03 medical and health sciences ,0302 clinical medicine ,abnormally invasive placenta ,Pregnancy ,interventional radiology ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,education ,education.field_of_study ,030219 obstetrics & reproductive medicine ,Hysterectomy ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,Obstetrics ,business.industry ,Obstetrics and Gynecology ,Interventional radiology ,General Medicine ,Odds ratio ,medicine.disease ,Reproductive Medicine ,percreta ,Female ,Fresh frozen plasma ,placenta accreta ,Packed red blood cells ,business - Abstract
OBJECTIVE To evaluate the potential benefit of interventional radiology (IR) in improving the outcome of women undergoing surgery for a placenta accreta spectrum (PAS) disorder. METHODS MEDLINE, EMBASE and CINAHL databases were searched for studies comparing outcomes of women with a prenatal diagnosis of PAS who underwent an IR procedure before surgery vs those who did not, using a robust collection of terms relating to PAS. The primary outcome was intraoperative estimated blood loss (EBL). Secondary outcomes were the number of transfused units of packed red blood cells (PRBC), fresh frozen plasma (FFP), platelets and cryoprecipitate, operation time, length of hospital stay, EBL ≥ 2.5 L, PRBC transfused ≥ 5 units, surgical complications, bladder or ureteral injury, relaparotomy, infection, disseminated intravascular coagulation, and complications related to endovascular catheter placement. Only studies reporting on the incidence of, or the mean difference in, the observed outcomes in women affected by a PAS disorder who had vs those who did not have an IR procedure before surgery were considered for inclusion. All outcomes were explored in the overall population of women with a prenatally diagnosed PAS disorder and in those undergoing hysterectomy. Quality assessment of each included study was performed using the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool. The GRADE methodology was used to assess the quality of the body of retrieved evidence. RESULTS Fifteen studies (958 women with PAS) were included. In women who underwent IR before surgery, compared with those who did not, mean EBL (mean difference (MD), -1.02 L; 95% CI, -1.60 to -0.43 L; P
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- 2019
32. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19
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Eran Hadar, Chiara Benedetto, Agnese Maria Chiara Rapisarda, Renato Augusto Moreira de Sá, Deena Elkafrawi, Daniela Luvero, Noa A Brzezinski Sinai, Alicia Martínez-Varea, Antonio Schiattarella, Anna Nunzia Della Gatta, Giovanni Scambia, Albert Lila, Luciano Di Tizio, Andrea Carosso, Giovanni Nazzaro, G. Schera, Giuseppe Rizzo, Giuseppe Maria Maruotti, Giusella D'Urso, Albaro José Nieto-Calvache, Ilenia Mappa, Ozlem Uyaniklar, Fabio Barra, Gilles Faron, Luigi Nappi, Jacopo Ferrari, Giulio Sozzi, Simone Ferrero, Mirjam Druškovič, Tanja Premru-Srsen, Leonardo Borrello, Fabiana Cecchini D, George Daskalakis, Giuliano Petriglia, Caroline Kadji, Felipe Mercado-Olivares, Zeliha Atak, Aylin Pelin Cil, Claudio Gustavino, Axelle Pintiaux, Pantaleo Greco, Rita Figueiredo, Stefano Cosma, Ludovica Puri, Valentina Esposito, Anupam Parange, Simone Garzon, Alessandra Gatti, Ioannis Kyvernitakis, Roberto Brunelli, Maddalena Morlando, Attilio Di Spiezio Sardo, Ignacio Cueto Hernández, Giuseppe Zoccali, Brian Rodriguez, Antonio Mollo, Flaminia Vena, Cihat Sen, Ciuhodaru Madalina, Felice Sorrentino, Francesca Di Sebastiano, Gennady T. Sukhikh, Ilma Floriana Carbone, Andrea Villasco, Blanka Zlatohlavkova, Gabriele Saccone, Erasmo Huertas, Marcel Malan, Leonardo Gucciardo, Eutalia Esposito, Otto Henrique May Feuerschuette, Sarah Dollinger, María de Los Angeles Anaya Baz, Jun Yoshimatsu, Sifa Turan, Vincente Diago, Alicia Yeliz Aykanat, Ignacio Herraiz, Javier Alfonso Schvartzman, Diego Gazzolo, Natalina Buono, Milan Stanojević, Erich Cosmi, Valentina De Robertis, Elena Costa, Angelo Cagnacci, Eleonora Valori, Nicoletta Biglia, Şerife Özlem Genç, Vincenzo Berghella, Francesco Maria Colaleo, Esther Vanessa Aguilar Galán, Gabriela Loscalzo, Marco Palumbo, Fabrizio Sandri, Irmeli Nupponen, Antonio Lanzone, Juan Antonio De León Luis, Amos Grunebaum, Giuseppe Bifulco, Marinella Lenzi, Serena Xodo, Fulvio Zullo, Ozhan Turan, Josefine Königbauer, Anna Luengo Piqueras, Nicola Volpe, Holger Maul, Chiara Taccaliti, Juan Manuel Burgos-Luna, Giovanni Sisti, Rosanna Esposito, Alfredo Ercoli, Panos Antsaklis, Dolores Esteban Oliva, Aly Youssef, Pedro Viana Pinto, Alberto Galindo, Asim Kurjak, Erhan Okuyan, Roberto Angioli, Maria Luisa Gonzalez-Duran, Ana Concheiro Guisan, Massimo Franchi, Maria Carmela Di Dedda, Giovanni Gerosolima, Francesco D'Antonio, Caroline Daelemans, Quintino Cesare Ianniciello, Pasquale De Franciscis, Maurizio Guida, Maria Cristina Rovellotti, Liana Ples, Frank A. Chervenak, Nicola Colacurci, Lilijana Kornhauser Cerar, Zulfiya Khodjaeva, Valentina Longo, Francesca Stollagli, Daniele Di Mascio, Mariavittoria Locci, Amadeo Sanchez, Angelo Sirico, Stefania Fieni, Rebeca Garrote Molpeceres, Pierluigi Benedetti Panici, Vito Chiantera, Esra Tustas Haberal, Liviu Cojocaru, Maria Elena Flacco, Antonella Cromi, Roberta Granese, Antonio Simone Laganà, Maria Giulia Lombana Marino, Silvia Visentin, Beatrice Bianchi, Roberta Venturella, Federica Laraud, Amanda Bermejo, Reyhan Gündüz, Marina Moucho, Zita Maria Gambacorti-Passerini, Danila Morano, Pedro Arango, Francesca Della Sala, Gaetana Di Donna, Jesús S Jimenez Lopez, Mariano Catello Di Donna, Giuliana Simonazzi, Snezana Zdjelar, Vedran Stefanovic, Cecilia Villalain, Antonio Coviello, Lars Hellmeyer, Antonella Giancotti, Elisa Bevilacqua, Igor Samardjiski, Riccardo Buscemi, Arianna Ramone, Marco Cerbone, Lorenza Driul, Danilo Buca, Tiziana Frusca, Elisa Done, Marco Liberati, José Morales Roselló, Fabio Ghezzi, Lorenzo Vasciaveo, Bernd Froessler, Alejandro Pittaro, Yolanda Cuñarro López, Andrew Carlin, Sakine Rahimli Ocakouglu, Giorgia Gattei, I. Cataneo, María José Suárez, Giada Ameli, Lamberto Manzoli, Kaisa Nelskylä, Ludovico Muzii, Peter Palm, Olus Api, Elisa Cueto, Martina Leombroni, Ksenia A. Gorina, HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology, Children's Hospital, HUS Children and Adolescents, HUS Perioperative, Intensive Care and Pain Medicine, Anestesiologian yksikkö, Department of Diagnostics and Therapeutics, Dicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı, Gündüz, Reyhan, Di Mascio D., Sen C., Saccone G., Galindo A., Grunebaum A., Yoshimatsu J., Stanojevic M., Kurjak A., Chervenak F., Suarez M.J.R., Gambacorti-Passerini Z.M., De Los Angeles Anaya Baz M., Galan E.V.A., Lopez Y.C., De Leon Luis J.A., Hernandez I.C., Herraiz I., Villalain C., Venturella R., Rizzo G., Mappa I., Gerosolima G., Hellmeyer L., Konigbauer J., Ameli G., Frusca T., Volpe N., Schera G.B.L., Fieni S., Esposito E., Simonazzi G., Di Donna G., Youssef A., Della Gatta A.N., Di Donna M.C., Chiantera V., Buono N., Sozzi G., Greco P., Morano D., Bianchi B., Marino M.G.L., Laraud F., Ramone A., Cagnacci A., Barra F., Gustavino C., Ferrero S., Ghezzi F., Cromi A., Lagana A.S., Longo V.L., Stollagli F., Sirico A., Lanzone A., Driul L., Fabiana Cecchini D., Xodo S., Rodriguez B., Mercado-Olivares F., Elkafrawi D., Sisti G., Esposito R., Coviello A., Cerbone M., Morlando M., Schiattarella A., Colacurci N., De Franciscis P., Cataneo I., Lenzi M., Sandri F., Buscemi R., Gattei G., Della Sala F., Valori E., Rovellotti M.C., Done E., Faron G., Gucciardo L., Esposito V., Vena F., Giancotti A., Brunelli R., Muzii L., Nappi L., Sorrentino F., Vasciaveo L., Liberati M., Buca D., Leombroni M., Di Sebastiano F., Di Tizio L., Gazzolo D., Franchi M., Ianniciello Q.C., Garzon S., Petriglia G., Borrello L., Nieto-Calvache A.J., Burgos-Luna J.M., Kadji C., Carlin A., Bevilacqua E., Moucho M., Pinto P.V., Figueiredo R., Rosello J.M., Loscalzo G., Martinez-Varea A., Diago V., Lopez J.S.J., Aykanat A.Y., Cosma S., Carosso A., Benedetto C., Bermejo A., Feuerschuette O.H.M., Uyaniklar O., Ocakouglu S.R., Atak Z., Gunduz R., Haberal E.T., Froessler B., Parange A., Palm P., Samardjiski I., Taccaliti C., Okuyan E., Daskalakis G., De Sa R.A.M., Pittaro A., Gonzalez-Duran M.L., Guisan A.C., Genc S.O., Zlatohlavkova B., Piqueras A.L., Oliva D.E., Cil A.P., Api O., Antsaklis P., Ples L., Kyvernitakis I., Maul H., Malan M., Lila A., Granese R., Ercoli A., Zoccali G., Villasco A., Biglia N., Madalina C., Costa E., Daelemans C., Pintiaux A., Cueto E., Hadar E., Dollinger S., Sinai N.A.B., Huertas E., Arango P., Sanchez A., Schvartzman J.A., Cojocaru L., Turan S., Turan O., Di Dedda M.C., Molpeceres R.G., Zdjelar S., Premru-Srsen T., Cerar L.K., Druskovie M., De Robertis V., Stefanovic V., Nupponen I., Nelskyla K., Khodjaeva Z., Gorina K.A., Sukhikh G.T., Maruotti G.M., Visentin S., Cosmi E., Ferrari J., Gatti A., Luvero D., Angioli R., Puri L., Palumbo M., D'Urso G., Colaleo F., Rapisarda A.M.C., Carbone I.F., Mollo A., Nazzaro G., Locci M., Guida M., Di Spiezio Sardo A., Panici P.B., Berghella V., Flacco M.E., Manzoli L., Bifulco G., Scambia G., Zullo F., D'Antonio F., Di Mascio D, Sen C, Saccone G, Galindo A, Grünebaum A, Yoshimatsu J, Stanojevic M, Kurjak A, Chervenak F, Rodríguez Suárez MJ, Gambacorti-Passerini ZM, Baz MLAA, Aguilar Galán EV, López YC, De León Luis JA, Hernández IC, Herraiz I, Villalain C, Venturella R, Rizzo G, Mappa I, Gerosolima G, Hellmeyer L, Königbauer J, Ameli G, Frusca T, Volpe N, Luca Schera GB, Fieni S, Esposito E, Simonazzi G, Di Donna G, Youssef A, Della Gatta AN, Di Donna MC, Chiantera V, Buono N, Sozzi G, Greco P, Morano D, Bianchi B, Lombana Marino MG, Laraud F, Ramone A, Cagnacci A, Barra F, Gustavino C, Ferrero S, Ghezzi F, Cromi A, Laganà AS, Laurita Longo V, Stollagli F, Sirico A, Lanzone A, Driul L, Cecchini D F, Xodo S, Rodriguez B, Mercado-Olivares F, Elkafrawi D, Sisti G, Esposito R, Coviello A, Cerbone M, Morlando M, Schiattarella A, Colacurci N, De Franciscis P, Cataneo I, Lenzi M, Sandri F, Buscemi R, Gattei G, Sala FD, Valori E, Rovellotti MC, Done E, Faron G, Gucciardo L, Esposito V, Vena F, Giancotti A, Brunelli R, Muzii L, Nappi L, Sorrentino F, Vasciaveo L, Liberati M, Buca D, Leombroni M, Di Sebastiano F, Di Tizio L, Gazzolo D, Franchi M, Ianniciello QC, Garzon S, Petriglia G, Borrello L, Nieto-Calvache AJ, Burgos-Luna JM, Kadji C, Carlin A, Bevilacqua E, Moucho M, Pinto PV, Figueiredo R, Roselló JM, Loscalzo G, Martinez-Varea A, Diago V, Jimenez Lopez JS, Aykanat AY, Cosma S, Carosso A, Benedetto C, Bermejo A, May Feuerschuette OH, Uyaniklar O, Ocakouglu SR, Atak Z, Gündüz R, Haberal ET, Froessler B, Parange A, Palm P, Samardjiski I, Taccaliti C, Okuyan E, Daskalakis G, Moreira de Sa RA, Pittaro A, Gonzalez-Duran ML, Guisan AC, Genç ŞÖ, Zlatohlávková B, Piqueras AL, Oliva DE, Cil AP, Api O, Antsaklis P, Ples L, Kyvernitakis I, Maul H, Malan M, Lila A, Granese R, Ercoli A, Zoccali G, Villasco A, Biglia N, Madalina C, Costa E, Daelemans C, Pintiaux A, Cueto E, Hadar E, Dollinger S, Brzezinski Sinai NA, Huertas E, Arango P, Sanchez A, Schvartzman JA, Cojocaru L, Turan S, Turan O, Di Dedda MC, Molpeceres RG, Zdjelar S, Premru-Srsen T, Cerar LK, Druškovič M, De Robertis V, Stefanovic V, Nupponen I, Nelskylä K, Khodjaeva Z, Gorina KA, Sukhikh GT, Maruotti GM, Visentin S, Cosmi E, Ferrari J, Gatti A, Luvero D, Angioli R, Puri L, Palumbo M, D'Urso G, Colaleo F, Chiara Rapisarda AM, Carbone IF, Mollo A, Nazzaro G, Locci M, Guida M, Di Spiezio Sardo A, Panici PB, Berghella V, Flacco ME, Manzoli L, Bifulco G, Scambia G, Zullo F, D'Antonio F, Di Mascio, D., Sen, C., Saccone, G., Galindo, A., Grunebaum, A., Yoshimatsu, J., Stanojevic, M., Kurjak, A., Chervenak, F., Suarez, M. J. R., Gambacorti-Passerini, Z. M., De Los Angeles Anaya Baz, M., Galan, E. V. A., Lopez, Y. C., De Leon Luis, J. A., Hernandez, I. C., Herraiz, I., Villalain, C., Venturella, R., Rizzo, G., Mappa, I., Gerosolima, G., Hellmeyer, L., Konigbauer, J., Ameli, G., Frusca, T., Volpe, N., Schera, G. B. L., Fieni, S., Esposito, E., Simonazzi, G., Di Donna, G., Youssef, A., Della Gatta, A. N., Di Donna, M. C., Chiantera, V., Buono, N., Sozzi, G., Greco, P., Morano, D., Bianchi, B., Marino, M. G. L., Laraud, F., Ramone, A., Cagnacci, A., Barra, F., Gustavino, C., Ferrero, S., Ghezzi, F., Cromi, A., Lagana, A. S., Longo, V. L., Stollagli, F., Sirico, A., Lanzone, A., Driul, L., Fabiana Cecchini, D., Xodo, S., Rodriguez, B., Mercado-Olivares, F., Elkafrawi, D., Sisti, G., Esposito, R., Coviello, A., Cerbone, M., Morlando, M., Schiattarella, A., Colacurci, N., De Franciscis, P., Cataneo, I., Lenzi, M., Sandri, F., Buscemi, R., Gattei, G., Della Sala, F., Valori, E., Rovellotti, M. C., Done, E., Faron, G., Gucciardo, L., Esposito, V., Vena, F., Giancotti, A., Brunelli, R., Muzii, L., Nappi, L., Sorrentino, F., Vasciaveo, L., Liberati, M., Buca, D., Leombroni, M., Di Sebastiano, F., Di Tizio, L., Gazzolo, D., Franchi, M., Ianniciello, Q. C., Garzon, S., Petriglia, G., Borrello, L., Nieto-Calvache, A. J., Burgos-Luna, J. M., Kadji, C., Carlin, A., Bevilacqua, E., Moucho, M., Pinto, P. V., Figueiredo, R., Rosello, J. M., Loscalzo, G., Martinez-Varea, A., Diago, V., Lopez, J. S. J., Aykanat, A. Y., Cosma, S., Carosso, A., Benedetto, C., Bermejo, A., Feuerschuette, O. H. M., Uyaniklar, O., Ocakouglu, S. R., Atak, Z., Gunduz, R., Haberal, E. T., Froessler, B., Parange, A., Palm, P., Samardjiski, I., Taccaliti, C., Okuyan, E., Daskalakis, G., De Sa, R. A. M., Pittaro, A., Gonzalez-Duran, M. L., Guisan, A. C., Genc, S. O., Zlatohlavkova, B., Piqueras, A. L., Oliva, D. E., Cil, A. P., Api, O., Antsaklis, P., Ples, L., Kyvernitakis, I., Maul, H., Malan, M., Lila, A., Granese, R., Ercoli, A., Zoccali, G., Villasco, A., Biglia, N., Madalina, C., Costa, E., Daelemans, C., Pintiaux, A., Cueto, E., Hadar, E., Dollinger, S., Sinai, N. A. B., Huertas, E., Arango, P., Sanchez, A., Schvartzman, J. A., Cojocaru, L., Turan, S., Turan, O., Di Dedda, M. C., Molpeceres, R. G., Zdjelar, S., Premru-Srsen, T., Cerar, L. K., Druskovie, M., De Robertis, V., Stefanovic, V., Nupponen, I., Nelskyla, K., Khodjaeva, Z., Gorina, K. A., Sukhikh, G. T., Maruotti, G. M., Visentin, S., Cosmi, E., Ferrari, J., Gatti, A., Luvero, D., Angioli, R., Puri, L., Palumbo, M., D'Urso, G., Colaleo, F., Rapisarda, A. M. C., Carbone, I. F., Mollo, A., Nazzaro, G., Locci, M., Guida, M., Di Spiezio Sardo, A., Panici, P. B., Berghella, V., Flacco, M. E., Manzoli, L., Bifulco, G., Scambia, G., Zullo, F., D'Antonio, F., Di Mascio, Daniele, Sen, Cihat, Saccone, Gabriele, Galindo, Alberto, Grünebaum, Amo, Yoshimatsu, Jun, Stanojevic, Milan, Kurjak, Asım, Chervenak, Frank, Rodríguez Suárez, María José, Gambacorti-Passerini, Zita Maria, Baz, María de Los Angeles Anaya, Aguilar Galán, Esther Vanessa, López, Yolanda Cuñarro, De León Luis, Juan Antonio, Hernández, Ignacio Cueto, Herraiz, Ignacio, Villalain, Cecilia, Venturella, Roberta, Rizzo, Giuseppe, Mappa, Ilenia, Gerosolima, Giovanni, Hellmeyer, Lar, Königbauer, Josefine, Ameli, Giada, Frusca, Tiziana, Volpe, Nicola, Luca Schera, Giovanni Battista, Fieni, Stefania, Esposito, Eutalia, Simonazzi, Giuliana, Di Donna, Gaetana, Youssef, Aly, Della Gatta, Anna Nunzia, Di Donna, Mariano Catello, Chiantera, Vito, Buono, Natalina, Sozzi, Giulio, Greco, Pantaleo, Morano, Danila, Bianchi, Beatrice, Lombana Marino, Maria Giulia, Laraud, Federica, Ramone, Arianna, Cagnacci, Angelo, Barra, Fabio, Gustavino, Claudio, Ferrero, Simone, Ghezzi, Fabio, Cromi, Antonella, Laganà, Antonio Simone, Longo, Valentina Laurita, Stollagli, Francesca, Sirico, Angelo, Lanzone, Antonio, Driul, Lorenza, Cecchini D, Fabiana, Xodo, Serena, Rodriguez, Brian, Mercado-Olivares, Felipe, Elkafrawi, Deena, Sisti, Giovanni, Esposito, Rosanna, Coviello, Antonio, Cerbone, Marco, Morlando, Maddalena, Schiattarella, Antonio, Colacurci, Nicola, De Franciscis, Pasquale, Cataneo, Ilaria, Lenzi, Marinella, Sandri, Fabrizio, Buscemi, Riccardo, Gattei, Giorgia, Sala, Francesca Della, Valori, Eleonora, Rovellotti, Maria Cristina, Done, Elisa, Faron, Gille, Gucciardo, Leonardo, Esposito, Valentina, Vena, Flaminia, Giancotti, Antonella, Brunelli, Roberto, Muzii, Ludovico, Nappi, Luigi, Sorrentino, Felice, Vasciaveo, Lorenzo, Liberati, Marco, Buca, Danilo, Leombroni, Martina, Di Sebastiano, Francesca, Di Tizio, Luciano, Gazzolo, Diego, Franchi, Massimo, Ianniciello, Quintino Cesare, Garzon, Simone, Petriglia, Giuliano, Borrello, Leonardo, Nieto-Calvache, Albaro Josè, Burgos-Luna, Juan Manuel, Kadji, Caroline, Carlin, Andrew, Bevilacqua, Elisa, Moucho, Marina, Pinto, Pedro Viana, Figueiredo, Rita, Roselló, José Morale, Loscalzo, Gabriela, Martinez-Varea, Alicia, Diago, Vincente, Jimenez Lopez, Jesús S, Aykanat, Alicia Yeliz, Cosma, Stefano, Carosso, Andrea, Benedetto, Chiara, Bermejo, Amanda, May Feuerschuette, Otto Henrique, Uyaniklar, Ozlem, Ocakouglu, Sakine Rahimli, Atak, Zeliha, Haberal, Esra Tusta, Froessler, Bernd, Parange, Anupam, Palm, Peter, Samardjiski, Igor, Taccaliti, Chiara, Okuyan, Erhan, Daskalakis, George, Moreira de Sa, Renato Augusto, Pittaro, Alejandro, Gonzalez-Duran, Maria Luisa, Guisan, Ana Concheiro, Genç, Şerife Özlem, Zlatohlávková, Blanka, Piqueras, Anna Luengo, Oliva, Dolores Esteban, Cil, Aylin Pelin, Api, Olu, Antsaklis, Pano, Ples, Liana, Kyvernitakis, Ioanni, Maul, Holger, Malan, Marcel, Lila, Albert, Granese, Roberta, Ercoli, Alfredo, Zoccali, Giuseppe, Villasco, Andrea, Biglia, Nicoletta, Madalina, Ciuhodaru, Costa, Elena, Daelemans, Caroline, Pintiaux, Axelle, Yapar Eyi, Elif Gül, Cueto, Elisa, Hadar, Eran, Dollinger, Sarah, Brzezinski Sinai, Noa A, Huertas, Erasmo, Arango, Pedro, Sanchez, Amadeo, Schvartzman, Javier Alfonso, Cojocaru, Liviu, Turan, Sifa, Turan, Ozhan, Di Dedda, Maria Carmela, Molpeceres, Rebeca Garrote, Zdjelar, Snezana, Premru-Srsen, Tanja, Cerar, Lilijana Kornhauser, Druškovič, Mirjam, De Robertis, Valentina, Stefanovic, Vedran, Nupponen, Irmeli, Nelskylä, Kaisa, Khodjaeva, Zulfiya, Gorina, Ksenia A, Sukhikh, Gennady T, Maruotti, Giuseppe Maria, Visentin, Silvia, Cosmi, Erich, Ferrari, Jacopo, Gatti, Alessandra, Luvero, Daniela, Angioli, Roberto, Puri, Ludovica, Palumbo, Marco, D'Urso, Giusella, Colaleo, Francesco, Chiara Rapisarda, Agnese Maria, Carbone, Ilma Floriana, Mollo, Antonio, Nazzaro, Giovanni, Locci, Mariavittoria, Guida, Maurizio, Di Spiezio Sardo, Attilio, Panici, Pierluigi Benedetti, Berghella, Vincenzo, Flacco, Maria Elena, Manzoli, Lamberto, Bifulco, Giuseppe, Scambia, Giovanni, Zullo, Fulvio, and D'Antonio, Francesco
- Subjects
COVID-19 Vaccine ,Infectious Disease Transmission ,Perinatal Death ,Abortion ,Clinical Laboratory Technique ,Miscarriage ,Cohort Studies ,0302 clinical medicine ,COVID-19 Testing ,Pregnancy ,Risk Factors ,3123 Gynaecology and paediatrics ,Secondary analysis ,Perinatal medicine ,Abortion, Spontaneou ,Medicine ,Vertical ,030212 general & internal medicine ,Viral ,Pregnancy Complications, Infectious ,coronavirus ,perinatal morbidity ,perinatal mortality ,covid-19 ,Coronavirus ,Abortion, Spontaneous ,COVID-19 ,COVID-19 Vaccines ,Clinical Laboratory Techniques ,Coronavirus Infections ,Female ,Gestational Age ,Humans ,Infant, Newborn ,Infant, Premature ,Infectious Disease Transmission, Vertical ,Pandemics ,Pneumonia, Viral ,Pregnancy Outcome ,Reverse Transcriptase Polymerase Chain Reaction ,SARS-CoV-2 ,Betacoronavirus ,Fetal Death ,030219 obstetrics & reproductive medicine ,Obstetrics ,Infectious ,Gestational age ,Obstetrics and Gynecology ,3. Good health ,Settore MED/40 ,Gestation ,Human ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Coronaviru ,Socio-culturale ,Intrauterine device ,03 medical and health sciences ,PARVOVIRUS B19 INFECTION ,Coronavirus, perinatal morbidity, perinatal mortality ,Adverse effect ,Premature ,Fetus ,Betacoronaviru ,Pandemic ,Coronavirus Infection ,business.industry ,Risk Factor ,Spontaneous ,MORTALITY ,Infant ,Odds ratio ,Pneumonia ,medicine.disease ,Newborn ,Pregnancy Complications ,Pediatrics, Perinatology and Child Health ,Pregnancy Complications, Infectiou ,Cohort Studie ,business - Abstract
Objectives To evaluate the strength of association between maternal and pregnancy characteristics and the risk of adverse perinatal outcomes in pregnancies with laboratory confirmed COVID-19. Methods Secondary analysis of a multinational, cohort study on all consecutive pregnant women with laboratory-confirmed COVID-19 from February 1, 2020 to April 30, 2020 from 73 centers from 22 different countries. A confirmed case of COVID-19 was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite adverse fetal outcome, defined as the presence of either abortion (pregnancy loss before 22 weeks of gestations), stillbirth (intrauterine fetal death after 22 weeks of gestation), neonatal death (death of a live-born infant within the first 28 days of life), and perinatal death (either stillbirth or neonatal death). Logistic regression analysis was performed to evaluate parameters independently associated with the primary outcome. Logistic regression was reported as odds ratio (OR) with 95% confidence interval (CI). Results Mean gestational age at diagnosis was 30.6±9.5 weeks, with 8.0% of women being diagnosed in the first, 22.2% in the second and 69.8% in the third trimester of pregnancy. There were six miscarriage (2.3%), six intrauterine device (IUD) (2.3) and 5 (2.0%) neonatal deaths, with an overall rate of perinatal death of 4.2% (11/265), thus resulting into 17 cases experiencing and 226 not experiencing composite adverse fetal outcome. Neither stillbirths nor neonatal deaths had congenital anomalies found at antenatal or postnatal evaluation. Furthermore, none of the cases experiencing IUD had signs of impending demise at arterial or venous Doppler. Neonatal deaths were all considered as prematurity-related adverse events. Of the 250 live-born neonates, one (0.4%) was found positive at RT-PCR pharyngeal swabs performed after delivery. The mother was tested positive during the third trimester of pregnancy. The newborn was asymptomatic and had negative RT-PCR test after 14 days of life. At logistic regression analysis, gestational age at diagnosis (OR: 0.85, 95% CI 0.8–0.9 per week increase; p Conclusions Early gestational age at infection, maternal ventilatory supports and low birthweight are the main determinants of adverse perinatal outcomes in fetuses with maternal COVID-19 infection. Conversely, the risk of vertical transmission seems negligible.
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- 2021
33. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection
- Author
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Di Mascio Daniele, Gabriele, Saccone, Cihat, Sen, Daniele Di Mascio, Alberto, Galindo, Amos, Grünebaum, Jun, Yoshimatsu, Milan, Stanojevic, Asım, Kurjak, Frank, Chervenak, María José Rodríguez Suárez, Zita Maria Gambacorti-Passerini, María de Los Angeles Anaya Baz, Esther Vanessa Aguilar Galán, Yolanda Cuñarro López, Juan Antonio De León Luis, Ignacio Cueto Hernández, Ignacio, Herraiz, Cecilia, Villalain, Roberta, Venturella, Rizzo, GIUSEPPE DAVIDE, Ilenia, Mappa, Giovanni, Gerosolima, Lars, Hellmeyer, Josefine, Königbauer, Giada, Ameli, Tiziana, Frusca, Nicola, Volpe, Giovanni Battista Luca Schera, Stefania, Fieni, Eutalia, Esposito, Giuliana, Simonazzi, Gaetana Di Donna, Aly, Youssef, Anna Nunzia Della Gatta, Mariano Catello Di Donna, Vito, Chiantera, Natalina, Buono, Giulio, Sozzi, Pantaleo, Greco, Danila, Morano, Beatrice, Bianchi, Maria Giulia Lombana Marino, Federica, Laraud, Arianna, Ramone, Angelo, Cagnacci, Fabio, Barra, Claudio, Gustavino, Ferrero, Simone, Fabio, Ghezzi, Antonella, Cromi, Antonio Simone Laganà, Valentina Laurita Longo, Francesca, Stollagli, Angelo, Sirico, Antonio, Lanzone, Lorenza, Driul, Fabiana, Cecchini, Serena, Xodo, Brian, Rodriguez, Felipe, Mercado-Olivares, Deena, Elkafrawi, Giovanni, Sisti, Rosanna, Esposito, Antonio, Coviello, Marco, Cerbone, Maddalena, Morlando, Antonio, Schiattarella, Nicola, Colacurci, Pasquale De Franciscis, Ilaria, Cataneo, Marinella, Lenzi, Fabrizio, Sandri, Riccardo, Buscemi, Giorgia, Gattei, Francesca Della Sala, Eleonora, Valori, Maria Cristina Rovellotti, Elisa, Done, Gilles, Faron, Leonardo, Gucciardo, Esposito, Valentina, Flaminia, Vena, Antonella, Giancotti, Roberto, Brunelli, Ludovico, Muzii, Luigi, Nappi, Felice, Sorrentino, Marco, Liberati, Danilo, Buca, Martina, Leombroni, Francesca Di Sebastiano, Massimo, Franchi, Quintino Cesare Ianniciello, Simone, Garzon, Giuliano, Petriglia, Leonardo, Borrello, Albaro Josè Nieto-Calvache, Juan Manuel Burgos-Luna, Caroline, Kadji, Andrew, Carlin, Elisa, Bevilacqua, Marina, Moucho, Pedro, Viana, Rita, Figueiredo, José Morales Roselló, Gabriela, Loscalzo, Alicia, Martinez-Varea, Vincente, Diago, Jesús, S Jimenez Lopez, Alicia Yeliz Aykanat, Cosma, Stefano Domenico, Carosso, ANDREA ROBERTO, Benedetto, Chiara, Amanda, Bermejo, Otto Henrique May Feuerschuette, Ozlem, Uyaniklar, Sakine Rahimli Ocakouglu, Zeliha, Atak, Reyhan, Gündüz, Esra Tustas Haberal, Bernd, Froessler, Anupam, Parange, Peter, Palm, Igor, Samardjiski, Chiara, Taccaliti, Erhan, Okuyan, George, Daskalakis, Renato Augusto Moreira de Sa, Alejandro, Pittaro, Maria Luisa Gonzalez-Duran, Ana Concheiro Guisan, Şerife Özlem Genç, Blanka, Zlatohlávková, Anna Luengo Piqueras, Dolores Esteban Oliva, Aylin Pelin Cil, Olus, Api, Panos, Antsaklis, Liana, Ples, Ioannis, Kyvernitakis, Holger, Maul, Marcel, Malan, Albert, Lila, Roberta, Granese, Alfredo, Ercoli, Giuseppe, Zoccali, Villasco, Andrea, Biglia, Nicoletta, Ciuhodaru, Madalina, Costa, Elena, Caroline, Daelemans, Axelle, Pintiaux, Elif Gül Yapar Eyi, Elisa, Cueto, Eran, Hadar, Sarah, Dollinger, Noa, A Brzezinski-Sinai, Erasmo, Huertas, Pedro, Arango, Amadeo, Sanchez, Javier Alfonso Schvartzman, Liviu, Cojocaru, Sifa, Turan, Ozhan, Turan, Maria Carmela Di Dedda, Rebeca Garrote Molpeceres, Snezana, Zdjelar, Tanja, Premru-Srsen, Lilijana, Kornhauser-Cerar, Mirjam, Druškovič, Valentina De Robertis, Vedran, Stefanovic, Irmeli, Nupponen, Kaisa, Nelskylä, Zulfiya, Khodjaeva, Ksenia, A Gorina, Gennady, T Sukhikh, Giuseppe Maria Maruotti, Silvia, Visentin, Erich, Cosmi, Jacopo, Ferrari, Alessandra, Gatti, Daniela, Luvero, Roberto, Angioli, Ludovica, Puri, Marco, Palumbo, Giusella, D'Urso, Francesco, Colaleo, Agnese Maria Chiara Rapisarda, Ilma Floriana Carbone, Manzoli, Lamberto, Maria Elena Flacco, Giovanni, Nazzaro, Mariavittoria, Locci, Maurizio, Guida, Attilio Di Spiezio Sardo, Pierluigi Benedetti Panici, Asma, Khalil, Vincenzo, Berghella, Giuseppe, Bifulco, Giovanni, Scambia, Fulvio, Zullo, Francesco, D'Antonio, Saccone, Gabriele, Sen, Cihat, Di Mascio, Daniele, Galindo, Alberto, Grünebaum, Amo, Yoshimatsu, Jun, Stanojevic, Milan, Kurjak, Asım, Chervenak, Frank, Suárez, María José Rodríguez, Gambacorti‐Passerini, Zita Maria, de los Angeles Anaya Baz, María, Galán, Esther Vanessa Aguilar, López, Yolanda Cuñarro, Luis, Juan Antonio De León, Hernández, Ignacio Cueto, Herraiz, Ignacio, Villalain, Cecilia, Venturella, Roberta, Rizzo, Giuseppe, Mappa, Ilenia, Gerosolima, Giovanni, Hellmeyer, Lar, Königbauer, Josefine, Ameli, Giada, Frusca, Tiziana, Volpe, Nicola, Schera, Giovanni Battista Luca, Fieni, Stefania, Esposito, Eutalia, Simonazzi, Giuliana, Di Donna, Gaetana, Youssef, Aly, Gatta, Anna Nunzia Della, Di Donna, Mariano Catello, Chiantera, Vito, Buono, Natalina, Sozzi, Giulio, Greco, Pantaleo, Morano, Danila, Bianchi, Beatrice, Marino, Maria Giulia Lombana, Laraud, Federica, Ramone, Arianna, Cagnacci, Angelo, Barra, Fabio, Gustavino, Claudio, Ferrero, Simone, Ghezzi, Fabio, Cromi, Antonella, Laganà, Antonio Simone, Longo, Valentina Laurita, Stollagli, Francesca, Sirico, Angelo, Lanzone, Antonio, Driul, Lorenza, Cecchini, Fabiana, Xodo, Serena, Rodriguez, Brian, Mercado‐Olivares, Felipe, Elkafrawi, Deena, Sisti, Giovanni, Esposito, Rosanna, Coviello, Antonio, Cerbone, Marco, Morlando, Maddalena, Schiattarella, Antonio, Colacurci, Nicola, De Franciscis, Pasquale, Cataneo, Ilaria, Lenzi, Marinella, Sandri, Fabrizio, Buscemi, Riccardo, Gattei, Giorgia, Sala, Francesca Della, Valori, Eleonora, Rovellotti, Maria Cristina, Done, Elisa, Faron, Gille, Gucciardo, Leonardo, Esposito, Valentina, Vena, Flaminia, Giancotti, Antonella, Brunelli, Roberto, Muzii, Ludovico, Nappi, Luigi, Sorrentino, Felice, Liberati, Marco, Buca, Danilo, Leombroni, Martina, Di Sebastiano, Francesca, Franchi, Massimo, Ianniciello, Quintino Cesare, Garzon, Simone, Petriglia, Giuliano, Borrello, Leonardo, Nieto‐Calvache, Albaro Josè, Burgos‐Luna, Juan Manuel, Kadji, Caroline, Carlin, Andrew, Bevilacqua, Elisa, Moucho, Marina, Viana Pinto, Pedro, Figueiredo, Rita, Morales Roselló, José, Loscalzo, Gabriela, Martinez‐Varea, Alicia, Diago, Vincente, Jimenez Lopez, Jesús S, Aykanat, Alicia Yeliz, Cosma, Stefano, Carosso, Andrea, Benedetto, Chiara, Bermejo, Amanda, Feuerschuette, Otto Henrique May, Uyaniklar, Ozlem, Ocakouglu, Sakine Rahimli, Atak, Zeliha, Gündüz, Reyhan, Haberal, Esra Tusta, Froessler, Bernd, Parange, Anupam, Palm, Peter, Samardjiski, Igor, Taccaliti, Chiara, Okuyan, Erhan, Daskalakis, George, de Sa, Renato Augusto Moreira, Pittaro, Alejandro, Gonzalez‐Duran, Maria Luisa, Guisan, Ana Concheiro, Genç, Şerife Özlem, Zlatohlávková, Blanka, Piqueras, Anna Luengo, Oliva, Dolores Esteban, Cil, Aylin Pelin, Api, Olu, Antsaklis, Pano, Ples, Liana, Kyvernitakis, Ioanni, Maul, Holger, Malan, Marcel, Lila, Albert, Granese, Roberta, Ercoli, Alfredo, Zoccali, Giuseppe, Villasco, Andrea, Biglia, Nicoletta, Madalina, Ciuhodaru, Costa, Elena, Daelemans, Caroline, Pintiaux, Axelle, Eyi, Elif Gül Yapar, Cueto, Elisa, Hadar, Eran, Dollinger, Sarah, Brzezinski‐Sinai, Noa A., Huertas, Erasmo, Arango, Pedro, Sanchez, Amadeo, Schvartzman, Javier Alfonso, Cojocaru, Liviu, Turan, Sifa, Turan, Ozhan, Di Dedda, Maria Carmela, Molpeceres, Rebeca Garrote, Zdjelar, Snezana, Premru‐Srsen, Tanja, Kornhauser‐Cerar, Lilijana, Druškovič, Mirjam, De Robertis, Valentina, Stefanovic, Vedran, Nupponen, Irmeli, Nelskylä, Kaisa, Khodjaeva, Zulfiya, Gorina, Ksenia A., Sukhikh, Gennady T., Maruotti, Giuseppe Maria, Visentin, Silvia, Cosmi, Erich, Ferrari, Jacopo, Gatti, Alessandra, Luvero, Daniela, Angioli, Roberto, Puri, Ludovica, Palumbo, Marco, D'Urso, Giusella, Colaleo, Francesco, Rapisarda, Agnese Maria Chiara, Carbone, Ilma Floriana, Manzoli, Lamberto, Flacco, Maria Elena, Nazzaro, Giovanni, Locci, Mariavittoria, Guida, Maurizio, Sardo, Attilio Di Spiezio, Panici, Pierluigi Benedetti, Khalil, Asma, Berghella, Vincenzo, Bifulco, Giuseppe, Scambia, Giovanni, Zullo, Fulvio, D'Antonio, Francesco, Dicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve DoğumAna Bilim Dalı, University of Helsinki, Department of Obstetrics and Gynecology, HUS Gynecology and Obstetrics, HUS Children and Adolescents, Children's Hospital, HUS Perioperative, Intensive Care and Pain Medicine, Anestesiologian yksikkö, Department of Diagnostics and Therapeutics, Saccone, G., Sen, C., Di Mascio, D., Galindo, A., Grunebaum, A., Yoshimatsu, J., Stanojevic, M., Kurjak, A., Chervenak, F., Suarez, M. J. R., Gambacorti-Passerini, Z. M., de los Angeles Anaya Baz, M., Galan, E. V. A., Lopez, Y. C., Luis, J. A. D. L., Hernandez, I. C., Herraiz, I., Villalain, C., Venturella, R., Rizzo, G., Mappa, I., Gerosolima, G., Hellmeyer, L., Konigbauer, J., Ameli, G., Frusca, T., Volpe, N., Schera, G. B. L., Fieni, S., Esposito, E., Simonazzi, G., Di Donna, G., Youssef, A., Gatta, A. N. D., Di Donna, M. C., Chiantera, V., Buono, N., Sozzi, G., Greco, P., Morano, D., Bianchi, B., Marino, M. G. L., Laraud, F., Ramone, A., Cagnacci, A., Barra, F., Gustavino, C., Ferrero, S., Ghezzi, F., Cromi, A., Lagana, A. S., Longo, V. L., Stollagli, F., Sirico, A., Lanzone, A., Driul, L., Cecchini, F., Xodo, S., Rodriguez, B., Mercado-Olivares, F., Elkafrawi, D., Sisti, G., Esposito, R., Coviello, A., Cerbone, M., Morlando, M., Schiattarella, A., Colacurci, N., De Franciscis, P., Cataneo, I., Lenzi, M., Sandri, F., Buscemi, R., Gattei, G., Sala, F. D., Valori, E., Rovellotti, M. C., Done, E., Faron, G., Gucciardo, L., Esposito, V., Vena, F., Giancotti, A., Brunelli, R., Muzii, L., Nappi, L., Sorrentino, F., Liberati, M., Buca, D., Leombroni, M., Di Sebastiano, F., Franchi, M., Ianniciello, Q. C., Garzon, S., Petriglia, G., Borrello, L., Nieto-Calvache, A. J., Burgos-Luna, J. M., Kadji, C., Carlin, A., Bevilacqua, E., Moucho, M., Viana Pinto, P., Figueiredo, R., Morales Rosello, J., Loscalzo, G., Martinez-Varea, A., Diago, V., Jimenez Lopez, J. S., Aykanat, A. Y., Cosma, S., Carosso, A., Benedetto, C., Bermejo, A., Feuerschuette, O. H. M., Uyaniklar, O., Ocakouglu, S. R., Atak, Z., Gunduz, R., Haberal, E. T., Froessler, B., Parange, A., Palm, P., Samardjiski, I., Taccaliti, C., Okuyan, E., Daskalakis, G., de Sa, R. A. M., Pittaro, A., Gonzalez-Duran, M. L., Guisan, A. C., Genc, S. O., Zlatohlavkova, B., Piqueras, A. L., Oliva, D. E., Cil, A. P., Api, O., Antsaklis, P., Ples, L., Kyvernitakis, I., Maul, H., Malan, M., Lila, A., Granese, R., Ercoli, A., Zoccali, G., Villasco, A., Biglia, N., Madalina, C., Costa, E., Daelemans, C., Pintiaux, A., Cueto, E., Hadar, E., Dollinger, S., Brzezinski-Sinai, N. A., Huertas, E., Arango, P., Sanchez, A., Schvartzman, J. A., Cojocaru, L., Turan, S., Turan, O., Di Dedda, M. C., Molpeceres, R. G., Zdjelar, S., Premru-Srsen, T., Kornhauser-Cerar, L., Druskovic, M., De Robertis, V., Stefanovic, V., Nupponen, I., Nelskyla, K., Khodjaeva, Z., Gorina, K. A., Sukhikh, G. T., Maruotti, G. M., Visentin, S., Cosmi, E., Ferrari, J., Gatti, A., Luvero, D., Angioli, R., Puri, L., Palumbo, M., D'Urso, G., Colaleo, F., Rapisarda, A. M. C., Carbone, I. F., Manzoli, L., Flacco, M. E., Nazzaro, G., Locci, M., Guida, M., Sardo, A. D. S., Panici, P. B., Khalil, A., Berghella, V., Bifulco, G., Scambia, G., Zullo, F., D'Antonio, F., José Rodríguez Suárez, María, Maria Gambacorti-Passerini, Zita, de Los Angeles Anaya Baz, María, Vanessa Aguilar Galán, Esther, Cuñarro López, Yolanda, Antonio De León Luis, Juan, Cueto Hernández, Ignacio, Battista Luca Schera, Giovanni, Nunzia Della Gatta, Anna, Catello Di Donna, Mariano, Giulia Lombana Marino, Maria, Simone Laganà, Antonio, Laurita Longo, Valentina, Mercado-Olivares, Felipe, Della Sala, Francesca, Cristina Rovellotti, Maria, Cesare Ianniciello, Quintino, Josè Nieto-Calvache, Albaro, Manuel Burgos-Luna, Juan, Viana, Pedro, Martinez-Varea, Alicia, S Jimenez Lopez, Jesú, Yeliz Aykanat, Alicia, DI BENEDETTO, Chiara, Henrique May Feuerschuette, Otto, Rahimli Ocakouglu, Sakine, Tustas Haberal, Esra, Augusto Moreira de Sa, Renato, Luisa Gonzalez-Duran, Maria, Concheiro Guisan, Ana, Özlem Genç, Şerife, Luengo Piqueras, Anna, Esteban Oliva, Dolore, Pelin Cil, Aylin, Gül Yapar Eyi, Elif, A Brzezinski-Sinai, Noa, Alfonso Schvartzman, Javier, Carmela Di Dedda, Maria, Garrote Molpeceres, Rebeca, Premru-Srsen, Tanja, Kornhauser-Cerar, Lilijana, A Gorina, Ksenia, T Sukhikh, Gennady, Maruotti, GIUSEPPE MARIA, Maria Chiara Rapisarda, Agnese, Floriana Carbone, Ilma, Elena Flacco, Maria, DI SPIEZIO SARDO, Attilio, Benedetti Panici, Pierluigi, Saccone G., Sen C., Di Mascio D., Galindo A., Grunebaum A., Yoshimatsu J., Stanojevic M., Kurjak A., Chervenak F., Suarez M.J.R., Gambacorti-Passerini Z.M., de los Angeles Anaya Baz M., Galan E.V.A., Lopez Y.C., Luis J.A.D.L., Hernandez I.C., Herraiz I., Villalain C., Venturella R., Rizzo G., Mappa I., Gerosolima G., Hellmeyer L., Konigbauer J., Ameli G., Frusca T., Volpe N., Schera G.B.L., Fieni S., Esposito E., Simonazzi G., Di Donna G., Youssef A., Gatta A.N.D., Di Donna M.C., Chiantera V., Buono N., Sozzi G., Greco P., Morano D., Bianchi B., Marino M.G.L., Laraud F., Ramone A., Cagnacci A., Barra F., Gustavino C., Ferrero S., Ghezzi F., Cromi A., Lagana A.S., Longo V.L., Stollagli F., Sirico A., Lanzone A., Driul L., Cecchini F., Xodo S., Rodriguez B., Mercado-Olivares F., Elkafrawi D., Sisti G., Esposito R., Coviello A., Cerbone M., Morlando M., Schiattarella A., Colacurci N., De Franciscis P., Cataneo I., Lenzi M., Sandri F., Buscemi R., Gattei G., Sala F.D., Valori E., Rovellotti M.C., Done E., Faron G., Gucciardo L., Esposito V., Vena F., Giancotti A., Brunelli R., Muzii L., Nappi L., Sorrentino F., Liberati M., Buca D., Leombroni M., Di Sebastiano F., Franchi M., Ianniciello Q.C., Garzon S., Petriglia G., Borrello L., Nieto-Calvache A.J., Burgos-Luna J.M., Kadji C., Carlin A., Bevilacqua E., Moucho M., Viana Pinto P., Figueiredo R., Morales Rosello J., Loscalzo G., Martinez-Varea A., Diago V., Jimenez Lopez J.S., Aykanat A.Y., Cosma S., Carosso A., Benedetto C., Bermejo A., Feuerschuette O.H.M., Uyaniklar O., Ocakouglu S.R., Atak Z., Gunduz R., Haberal E.T., Froessler B., Parange A., Palm P., Samardjiski I., Taccaliti C., Okuyan E., Daskalakis G., de Sa R.A.M., Pittaro A., Gonzalez-Duran M.L., Guisan A.C., Genc S.O., Zlatohlavkova B., Piqueras A.L., Oliva D.E., Cil A.P., Api O., Antsaklis P., Ples L., Kyvernitakis I., Maul H., Malan M., Lila A., Granese R., Ercoli A., Zoccali G., Villasco A., Biglia N., Madalina C., Costa E., Daelemans C., Pintiaux A., Cueto E., Hadar E., Dollinger S., Brzezinski-Sinai N.A., Huertas E., Arango P., Sanchez A., Schvartzman J.A., Cojocaru L., Turan S., Turan O., Di Dedda M.C., Molpeceres R.G., Zdjelar S., Premru-Srsen T., Kornhauser-Cerar L., Druskovic M., De Robertis V., Stefanovic V., Nupponen I., Nelskyla K., Khodjaeva Z., Gorina K.A., Sukhikh G.T., Maruotti G.M., Visentin S., Cosmi E., Ferrari J., Gatti A., Luvero D., Angioli R., Puri L., Palumbo M., D'Urso G., Colaleo F., Rapisarda A.M.C., Carbone I.F., Manzoli L., Flacco M.E., Nazzaro G., Locci M., Guida M., Sardo A.D.S., Panici P.B., Khalil A., Berghella V., Bifulco G., Scambia G., Zullo F., D'Antonio F., Mother and Child, Surgical clinical sciences, Obstetrics, and Clinical sciences
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COVID19 ,medicine.medical_treatment ,coronavirus ,COVID-19 ,infection ,pregnancy ,SARS-CoV-2 ,Abortion ,infectious diseases ,law.invention ,Cohort Studies ,0302 clinical medicine ,law ,3123 Gynaecology and paediatrics ,Pregnancy ,Obstetrics and Gynaecology ,030212 general & internal medicine ,Pregnancy Complications, Infectious ,030219 obstetrics & reproductive medicine ,Radiological and Ultrasound Technology ,Transmission (medicine) ,Obstetrics ,Pregnancy Outcome ,Obstetrics and Gynecology ,Coronavirus ,SARS-COV-2 ,General Medicine ,Disease 2019 Covid-19 ,Intensive care unit ,3. Good health ,Hospitalization ,Intensive Care Units ,Maternal Mortality ,Settore MED/40 ,Radiology Nuclear Medicine and imaging ,Gestation ,Female ,coronavirus, Pandemics, Pregnancy, Pregnancy Complications, Infectious, Pregnancy Outcome, Respiration, Artificial, Retrospective Studies, SARS-CoV-2, COVID-19, Infant, Newborn, Intensive Care Units,Maternal Mortality ,Infection ,Cohort study ,Adult ,medicine.medical_specialty ,NO ,03 medical and health sciences ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Pandemics ,Retrospective Studies ,Mechanical ventilation ,business.industry ,Infant, Newborn ,Infant ,Retrospective cohort study ,medicine.disease ,Respiration, Artificial ,coronaviru ,Reproductive Medicine ,business - Abstract
WOS:000613461600006 PubMed ID: 32926494 Objectives To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251(27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. Conclusions SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible. (C) 2020 International Society of Ultrasound in Obstetrics and Gynecology.
- Published
- 2021
34. Diagnostic Accuracy of Doppler Ultrasound in Predicting Perinatal Outcome in Appropriate for Gestational Age Fetuses: A Prospective Study
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Martina Leombroni, Giovanni Scambia, Marco Liberati, Alessandra Familiari, Sarah Gustapane, Cecilia Acuti Martellucci, Maria Elena Flacco, Francesca Bascietto, Danilo Buca, Francesco D'Antonio, Giuseppe Rizzo, Ilenia Mappa, Lamberto Manzoli, Luigi Nappi, Buca, Danilo, Rizzo, Giuseppe, Gustapane, Sarah, Mappa, Ilenia, Leombroni, Martina, Bascietto, Francesca, Flacco, Maria Elena, Acuti Martellucci, Cecilia, Manzoli, Lamberto, Nappi, Luigi, Familiari, Alessandra, Scambia, Giovanni, Liberati, Marco, and D'Antonio, Francesco
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medicine.medical_specialty ,Percentile ,Pregnancy Trimester, Third ,Socio-culturale ,Gestational Age ,Logistic regression ,Ultrasonography, Prenatal ,Umbilical Arteries ,030218 nuclear medicine & medical imaging ,neonatal outcome ,03 medical and health sciences ,0302 clinical medicine ,Fetus ,Predictive Value of Tests ,Pregnancy ,medicine.artery ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Prospective cohort study ,030219 obstetrics & reproductive medicine ,Obstetrics ,business.industry ,non-SGA fetuses ,Doppler ,Infant, Newborn ,Pregnancy Outcome ,Umbilical artery ,Ultrasonography, Doppler ,medicine.disease ,Doppler, pregnancy, CPR, neonatal outcome, non-SGA fetuses ,Settore MED/40 ,Middle cerebral artery ,Infant, Small for Gestational Age ,Gestation ,CPR ,Female ,business - Abstract
Objective To elucidate the role of Doppler ultrasound in predicting perinatal outcome in appropriate for gestational age (AGA) fetuses at term. Material and Methods Prospective study carried out in a dedicated research ultrasound clinic. The inclusion criterion was AGA fetuses, defined as those with an estimated fetal weight between the 10th and 90th percentile, at 36 + 0-37 + 6 weeks of gestation. The primary outcome was a composite score of adverse perinatal outcome including either adverse intrapartum events or abnormal acid-base status at birth. Secondary outcomes were the individual components of the primary outcome. The Doppler parameters explored were umbilical artery (UA) PI, middle cerebral artery (MCA) PI, uterine arteries (UtA) PI and cerebroplacental ratio (CPR). Attending clinicians were blinded to Doppler findings. Logistic regression and ROC curve analyses were used to analyze the data. Results 553 AGA fetuses were included. There was no difference in mean UA PI (p = 0.486), MCA PI (p = 0.621), CPR (p = 0.832) and UtA PI (p = 0.611) between pregnancies complicated by composite perinatal morbidity compared to those not complicated by composite perinatal morbidity. In pregnancies complicated by adverse intrapartum outcome, the mean MCA PI (1.47 ± 0.4 vs 1.61 ± 0.4, p = 0.0039) was lower compared to the control group, while there was no difference in UA PI (p = 0.758), CPR (p = 0.108), and UtA PI (p = 0.177). Finally, there was no difference in any of the Doppler parameters explored between AGA fetuses with abnormal acid-base status at birth compared to those without abnormal acid-base status at birth. In the logistic regression analysis, UA PI, MCA PI, CPR, UtA PI, EFW and AC percentiles were not independently associated with composite adverse outcome, adverse intrapartum outcome or abnormal acid-base status at birth in non-SGA fetuses. The diagnostic performance of all of these Doppler parameters for predicting composite adverse outcome, adverse intrapartum outcome and abnormal acid-base status was poor. Conclusion Cerebroplacental and maternal Doppler is not associated with or predictive of adverse pregnancy outcome in AGA fetuses close to term. Ziel Aufklärung der Rolle des Dopplerultraschalls bei der Vorhersage des perinatalen Outcomes von reifgeborenen Föten (AGA = appropriate for gestational age). Material und Methoden Prospektive Studie in einer speziellen Ultraschall- Forschungsklinik. Das Einschlusskriterium waren AGA-Föten, definiert durch ein geschätztes fetales Gewicht zwischen der 10. bis 90. Perzentile und der 36 + 0 bis 37 + 6 Schwangerschaftswoche. Der primäre Endpunkt war ein zusammengesetzter Score für das negative perinatale Outcome einschließlich unerwünschter intrapartaler Komplikationen oder einem abnormalen Säure-Basen-Status bei der Geburt. Den sekundären Endpunkt bildeten die Einzelparameter des primären Endpunkts. Die untersuchten Dopplerparameter waren der PI der A. umbilicalis (UA), der A. cerebri media (MCA) und der A. uterinae (UtA) und die zerebroplazentare Ratio (CPR). Die anwesenden Ärzte waren für die Dopplerbefunde blind. Zur Datenanalyse wurden logistische Regressions- und ROC-Kurvenanalysen verwendet. Ergebnisse 553 AGA-Föten wurden eingeschlossen. Es gab keinen Unterschied zwischen den mittleren Werten für UA-PI (p = 0,486), MCA-PI (p = 0,621), CPR (p = 0,832) und UtA-PI (p = 0,611) bei Schwangerschaften mit und ohne kombinierter perinataler Morbidität. In Schwangerschaften mit unerwünschten intrapartalen Komplikationen war der mittlere MCA-PI niedriger als in der Kontrollgruppe (1,47 ± 0,4 vs. 1,61 ± 0,4; p = 0,0039), während es keinen Unterschied zwischen UA-PI (p = 0,758), CPR (p = 0,108) und UtA-PI (p = 0,177) gab. Schließlich zeigten sich in keinem der untersuchten Dopplerparameter Unterschiede zwischen AGA-Föten mit abnormalem Säure-Basen-Status bei Geburt und solche ohne. In der logistischen Regressionsanalyse waren UA-PI, MCA-PI, CPR, UtA-PI, EFW und AC-Perzentilen nicht unabhängig voneinander mit einem kombinierten negativen Outcome, intrapartalen Komplikationen oder einem abnormalen Säure-Basen-Status bei der Geburt assoziiert. Die diagnostische Leistung all dieser Dopplerparameter zur Vorhersage von kombinierten intrapartalen Komplikationen und eines abnormalen Säure-Basen-Status war schlecht. Schlussfolgerung Bei AGA-Föten kurz vor Entbindung stehen zerebroplazentare und maternale Doppler nicht in Zusammenhang mit einem schlechten Schwangerschaftsoutcome bzw. sagen dieses voraus.
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- 2020
35. Post-partum pelvic floor dysfunction assessed on 3D rotational ultrasound: a prospective study on women with first- and second-degree perineal tears and episiotomy
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Danilo Buca, Francesco D'Antonio, Asma Khalil, Lamberto Manzoli, Eleonora Falò, Martina Leombroni, Alessandro Santarelli, Franco Frondaroli, Maria Elena Flacco, Giuseppe Rizzo, Alexander Makatsariya, Marco Liberati, Leombroni, Martina, Buca, Danilo, Liberati, Marco, Falò, Eleonora, Rizzo, Giuseppe, Khalil, Asma, Manzoli, Lamberto, Flacco, Maria Elena, Santarelli, Alessandro, Makatsariya, Alexander, Frondaroli, Franco, and D'Antonio, Francesco
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Episiotomy ,medicine.medical_specialty ,medicine.medical_treatment ,Levator ani muscle ,episiotomy ,Anal Canal ,Socio-culturale ,Perineum ,Kristeller maneuver ,Lacerations ,03 medical and health sciences ,0302 clinical medicine ,Pelvic floor dysfunction ,Pregnancy ,perineal tear ,Humans ,Medicine ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Post partum ,030219 obstetrics & reproductive medicine ,Pelvic floor ,3D pelvic floor ultrasound ,business.industry ,Obstetrics ,Postpartum Period ,Ultrasound ,Obstetrics and Gynecology ,Pelvic Floor ,perineal tears ,Delivery, Obstetric ,medicine.disease ,Obstetric Labor Complications ,body regions ,medicine.anatomical_structure ,levator ani muscle ,post-partum pelvic floor dysfunction ,Pediatrics, Perinatology and Child Health ,Tears ,Female ,Settore MED/40 - Ginecologia e Ostetricia ,business - Abstract
Purpose: To evaluate the morphology and biometry of pelvic floor structures 3 months after birth in women experiencing first- or second-degree perineal tears or undergoing episiotomy during labor. Material and methods: Prospective observational study including nulliparous women delivering at term with a clinical diagnosis of first- or second-degree perineal tears after birth or undergoing episiotomy. The role of Kristeller maneuver during labor in affecting pelvic structure and function is also explored. All women underwent 2D trans-perineal and 3D endovaginal or endoanal ultrasound 3 months after birth. Results: 115 women assessed 3 months after delivery were enrolled in the study. Compared with controls, women who experienced first-degree perineal tears had higher bladder neck-symphysis (versus 20.9 ± 4.9 versus 16.1 ± 4.9 mm, p = .017), bladder wall-pubic symphysis (22.4 ± 7.4 versus 14.2 ± 9.5 mm, p = .02) and anorectal angle-symphysis distance (12.5 ± 4.7 versus 9.3 ± 4.3 mm, p = .018). Furthermore, they have thicker internal and external anal sphincter. The incidence of partial right and left pubo-rectalis muscle avulsion was higher in women experiencing first-degree vaginal tear during labor (16.2 versus 0%, p = .004 for both). In women affected by second-degree tears, the occurrence of partial avulsion of the right and left pubo-rectalis muscle was 16.2%, while Oasis was detected in 10.8% of the cases. Women receiving Kristeller maneuver during labor had a higher incidence of either right or left puborectalis muscle avulsion. Conclusion: Women who had either first- and second-degree perineal tears or episiotomy show signs of abnormal pelvic morphometry on 3D rotational ultrasound 3 months after birth.
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- 2019
36. Outcomes associated with isolated agenesis of the corpus callosum: a meta-analysis
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Aris T. Papageorghiou, Alessandra Familiari, Giorgio Pagani, Ganesh Acharya, Catherine Garel, Marie Laure Moutard, Francesco D'Antonio, Amar Bhide, Gustavo Malinger, Asma Khalil, Zvi Leibovitz, Gianluigi Pilu, Martina Leombroni, Lamberto Manzoli, Federico Prefumo, Tally Lerman Sagies, D'Antonio, Francesco, Pagani, Giorgio, Familiari, Alessandra, Khalil, Asma, Sagies, Tally-Lerman, Malinger, Gustavo, Leibovitz, Zvi, Garel, Catherine, Moutard, Marie Laure, Pilu, Gianluigi, Bhide, Amar, Acharya, Ganesh, Leombroni, Martina, Manzoli, Lamberto, Papageorghiou, Ari, and Prefumo, Federico
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Pediatrics ,medicine.medical_specialty ,Concordance ,Socio-culturale ,Context (language use) ,Prenatal diagnosis ,Neuropsychological Tests ,03 medical and health sciences ,Epilepsy ,0302 clinical medicine ,Economica ,Pregnancy ,Prenatal Diagnosis ,medicine ,Humans ,Prospective cohort study ,Agenesis of the corpus callosum ,Chromosome Aberrations ,Language Disorders ,030219 obstetrics & reproductive medicine ,business.industry ,Infant, Newborn ,Ambientale ,Infant ,Perinatology and Child Health ,medicine.disease ,Magnetic Resonance Imaging ,Confidence interval ,Motor Skills Disorders ,Meta-analysis ,Pediatrics, Perinatology and Child Health ,Female ,Agenesis of Corpus Callosum ,business ,Cognition Disorders ,030217 neurology & neurosurgery - Abstract
CONTEXT: Antenatal counseling in cases of agenesis of the corpus callosum (ACC) is challenging. OBJECTIVES: To ascertain the outcome in fetuses with isolated complete ACC and partial ACC. DATA SOURCES: Medline, Embase, CINAHL, and Cochrane databases. STUDY SELECTION: Studies reporting a prenatal diagnosis of ACC. The outcomes observed were: chromosomal abnormalities at standard karyotype and chromosomal microarray (CMA) analysis, additional anomalies detected only at prenatal MRI and at postnatal imaging or clinical evaluation, concordance between prenatal and postnatal diagnosis and neurodevelopmental outcome. DATA EXTRACTION: Meta-analyses of proportions were used to combine data. RESULTS: Twenty-seven studies were included. In cACC, chromosomal anomalies occurred in 4.81% (95% confidence interval [CI], 2.2–8.4) of the cases. Gross and fine motor control were abnormal in 4.40% (95% CI, 0.6–11.3) and 10.98% (95% CI, 4.1–20.6) of the cases, respectively, whereas 6.80% (95% CI, 1.7–14.9) presented with epilepsy. Abnormal cognitive status occurred in 15.16% (95% CI, 6.9–25.9) of cases. In partial ACC, the rate of chromosomal anomalies was 7.45% (95% CI, 2.0–15.9). Fine motor control was affected in 11.74% (95% CI, 0.9–32.1) of the cases, and 16.11% (95% CI, 2.5–38.2) presented with epilepsy. Cognitive status was affected in 17.25% (95% CI, 3.0–39.7) of cases. LIMITATIONS: Different neurodevelopmental tools and time of follow-up of the included studies. CONCLUSIONS: Children wih a prenatal diagnosis of isolated ACC show several degrees of impairment in motor control, coordination, language, and cognitive status. However, in view of the large heterogeneity in outcomes measures, time at follow-up, and neurodevelopmental tools used, large prospective studies are needed to ascertain the actual occurrence of neuropsychological morbidity of children with isolated ACC.
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- 2016
37. Reproductive and pregnancy outcomes of fertility-sparing treatments for early-stage endometrial cancer or atypical hyperplasia: A systematic review and meta-analysis.
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De Rocco S, Buca D, Oronzii L, Petrillo M, Fanfani F, Nappi L, Liberati M, D'Antonio F, Scambia G, Leombroni M, Dessole M, and Lucidi A
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- Female, Humans, Hyperplasia, Levonorgestrel, Medroxyprogesterone Acetate, Pregnancy, Pregnancy Outcome, Abortion, Spontaneous epidemiology, Endometrial Hyperplasia drug therapy, Endometrial Hyperplasia pathology, Endometrial Neoplasms drug therapy, Fertility Preservation methods, Intrauterine Devices, Medicated, Precancerous Conditions
- Abstract
Objective: To report the pregnancy outcomes of women with prior endometrial cancer and endometrial hyperplasia managed with fertility-sparing treatments., Methods: Medline and Embase databases were searched. Inclusion criteria were studies reporting the pregnancy outcomes of women who had undergone fertility-sparing treatments for endometrial hyperplasia or early endometrioid endometrial cancer. Outcomes explored were pregnancy, miscarriage and livebirth rates according to the type of progestin treatment used. Subgroup analyses according to the type of diagnostic follow-up were also performed. Meta-analyses of proportions using a random effects model were used to combine data., Results: Twenty-nine studies (1036 women) were included, and 82.8% [95% confidence interval (CI) 72.3-91.2] of women achieved complete remission. Pregnancy rates were 56.3% (95% CI 41.6-70.5) with megestrol (MA) or medroxyprogesterone acetate (MPA), 63.1% (95% CI 37.0-85.6) with levonorgestrel-releasing intrauterine device (LNG-IUD), 57.9% (95% CI 37.7-76.8) with MA or MPA and metformin, 59.8% (95% CI 48.3-70.7) with MPA and LNG-IUD, 15.4% (95% CI 4.3-42.2) with gonadotropin-releasing hormone analogue (GnRHa) combined with LNG-IUD or letrozole, and 40.7% (95% CI 24.5-59.3) with LNG-IUD and GnRHa. Miscarriage rates were 17.4% (95% CI 12.2-23.4), 14.3% (95% CI 6.4-24.7), 57.9% (95% CI 37.7-76.8), 26.9% (95% CI 14.6-39.3), 100% (95% CI 34.0-100) and 18.2% (95% CI 5.1-47.7), respectively, and livebirth rates were 68.8% (95% CI 56.0-80.3), 80.8% (95% CI 69.5-90.0), 69.9% (95% CI 56.1-82.0), 25.97 (95% CI 14.6-39.3), 0% (95% CI 0-66.0) and 81.8% (95% CI 52.3-94.8), respectively. Finally, stratifying the analysis considering the endometrial sampling method alone, the pregnancy rate was 68.6% (95% CI 51.2-83.6; 10 studies, I
2 = 83.5%) in women who underwent hysteroscopy and 60.5% (95% CI 53.4-67.5; 13 studies, I2 = 39.8%) in women managed with dilatation and curettage biopsy; the miscarriage and livebirth rates were 13.2% (95% CI 8.0-19.5; I2 = 0%) and 81.2% (95% CI 67.4-91.8; I2 = 67.3%), respectively, for hysteroscopy, and 25.2% (95% CI 17.8-33.3; I2 = 15.5%) and 67.5% (95% CI 58.8-75.5; I2 = 0%), respectively, for dilatation and curettage biopsy., Conclusion: Fertility-sparing treatment in women with endometrial cancer or hyperplasia is associated with an overall good response to therapy, good chance of achieving pregnancy and a good livebirth rate. Diagnostic follow-up with hysteroscopy was associated with a higher pregnancy rate, although this requires confirmation in adequately powered randomized trials., (Copyright © 2022 Elsevier B.V. All rights reserved.)- Published
- 2022
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38. Diagnostic Accuracy of Doppler Ultrasound in Predicting Perinatal Outcome in Appropriate for Gestational Age Fetuses: A Prospective Study.
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Buca D, Rizzo G, Gustapane S, Mappa I, Leombroni M, Bascietto F, Flacco ME, Acuti Martellucci C, Manzoli L, Nappi L, Familiari A, Scambia G, Liberati M, and D'Antonio F
- Subjects
- Female, Fetus diagnostic imaging, Gestational Age, Humans, Infant, Newborn, Infant, Small for Gestational Age, Predictive Value of Tests, Pregnancy, Pregnancy Outcome, Pregnancy Trimester, Third, Prospective Studies, Ultrasonography, Doppler, Ultrasonography, Prenatal, Umbilical Arteries diagnostic imaging
- Abstract
Objective: To elucidate the role of Doppler ultrasound in predicting perinatal outcome in appropriate for gestational age (AGA) fetuses at term., Material and Methods: Prospective study carried out in a dedicated research ultrasound clinic. The inclusion criterion was AGA fetuses, defined as those with an estimated fetal weight between the 10
th and 90th percentile, at 36 + 0-37 + 6 weeks of gestation. The primary outcome was a composite score of adverse perinatal outcome including either adverse intrapartum events or abnormal acid-base status at birth. Secondary outcomes were the individual components of the primary outcome. The Doppler parameters explored were umbilical artery (UA) PI, middle cerebral artery (MCA) PI, uterine arteries (UtA) PI and cerebroplacental ratio (CPR). Attending clinicians were blinded to Doppler findings. Logistic regression and ROC curve analyses were used to analyze the data., Results: 553 AGA fetuses were included. There was no difference in mean UA PI (p = 0.486), MCA PI (p = 0.621), CPR (p = 0.832) and UtA PI (p = 0.611) between pregnancies complicated by composite perinatal morbidity compared to those not complicated by composite perinatal morbidity. In pregnancies complicated by adverse intrapartum outcome, the mean MCA PI (1.47 ± 0.4 vs 1.61 ± 0.4, p = 0.0039) was lower compared to the control group, while there was no difference in UA PI (p = 0.758), CPR (p = 0.108), and UtA PI (p = 0.177). Finally, there was no difference in any of the Doppler parameters explored between AGA fetuses with abnormal acid-base status at birth compared to those without abnormal acid-base status at birth. In the logistic regression analysis, UA PI, MCA PI, CPR, UtA PI, EFW and AC percentiles were not independently associated with composite adverse outcome, adverse intrapartum outcome or abnormal acid-base status at birth in non-SGA fetuses. The diagnostic performance of all of these Doppler parameters for predicting composite adverse outcome, adverse intrapartum outcome and abnormal acid-base status was poor., Conclusion: Cerebroplacental and maternal Doppler is not associated with or predictive of adverse pregnancy outcome in AGA fetuses close to term., Competing Interests: The authors declare that they have no conflict of interest., (Thieme. All rights reserved.)- Published
- 2021
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39. Corticosteroid prophylaxis for fetal immaturity in a pregnant patient with atrial myxoma.
- Author
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Di Giammarco G, Marchetti M, Foschi M, Marinelli D, Micucci D, Buca D, Leombroni M, and Di Mauro M
- Abstract
We report a case of a woman at 32nd gestational week, admitted for resting dyspnea, showing left atrial (LA) myxoma. Cardiac myxomas are the most common primary benign tumors of the heart. The incidence of cardiac myxomas diagnosed in pregnancy is extremely low. In the present case, cesarean delivery and concomitant surgical resection of LA myxoma were both delayed after corticosteroid prophylaxis in order to reduce neonatal cerebral, intestinal, and pulmonary complications. < Learning objective: The rarity of these cases makes the management more related to anecdotal experiences. In our case, the gestational age was lower than 34th week, but the fetus was sufficiently large to be delivered before heart surgery with low risk of prematurity complications after an adequate corticosteroid prophylaxis. A waiting approach with several days of corticosteroid prophylaxis was successfully adopted. When the pregnant hemodynamics are stable with low risk of complications, heart surgery should be delayed after corticosteroid prophylaxis.>.
- Published
- 2015
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