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4 results on '"Leola N. Y. Chow"'

1. Cathelicidin and Calprotectin Are Disparately Altered in Murine Models of Inflammatory Arthritis and Airway Inflammation

Author

Mahadevappa Hemshekhar, Hadeesha Piyadasa, Dina Mostafa, Leola N. Y. Chow, Andrew J. Halayko, and Neeloffer Mookherjee

Subjects
inflammation, cathelicidin, calprotectin, host defence peptides, antimicrobial peptides, arthritis, Immunologic diseases. Allergy, RC581-607
Abstract

Cationic host defense peptides (CHDP) are immunomodulatory molecules that control infections and contribute to immune homeostasis. CHDP such as cathelicidin and calprotectin expression is altered in the arthritic synovium, and in the lungs of asthma and COPD patients. Recent studies suggest a link between airway inflammation and the immunopathology of arthritis. Therefore, in this study we compared the abundance of mouse cathelicidin (CRAMP), defensins, and calprotectin subunits (S100A8 and S100A9) in murine models of collagen-induced arthritis (CIA) and allergen house dust mite (HDM)-challenged airway inflammation. CRAMP, S100A8, and S100A9 abundance were significantly elevated in the joint tissues of CIA mice, whereas these were decreased in the lung tissues of HDM-challenged mice, compared to naïve. We further compared the effects of administration of two different synthetic immunomodulatory peptides, IG-19 and IDR-1002, on cathelicidin and calprotectin abundance in the two models. Administration of IG-19, which controls disease progression and inflammation in CIA mice, significantly decreased CRAMP, S100A8, and S100A9 levels to baseline in the joints of the CIA mice, which correlated with the decrease in cellular influx in the joints. However, administration of IDR-1002, which suppresses HDM-induced airway inflammation, did not prevent the decrease in the levels of cathelicidin and calprotectin in the lungs of HDM-challenged mice. Cathelicidin and calprotectin levels did not correlate with leukocyte accumulation in the lungs of the HDM-challenged mice. Results of this study suggest that endogenous cathelicidin and calprotectin abundance are disparately altered, and may be differentially regulated, within local tissues in airway inflammation compared to arthritis.

Published
2020
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2. Small Wonders: Peptides for Disease Control

Author

Kanniah Rajasekaran, Jeffrey W. Cary, Jesse M. Jaynes, Emilio Montesinos, Neeloffer Mookherjee, Leola N. Y. Chow, Robert E. W. Hancock, Gregory C. Bernard, J. M. Conlon, Ashley L. Hilchie, Melanie R. Power Coombs, David W. Hoskin, Clayton Yates, Timothy Turner, Zhe Yan, Wendy J. Hartsock, Zhaohui Qian, Kathryn V. Holmes, Robert S. Hodges, Rachna Shah, Theresa L. Chang, V. Siva Rami Reddy, Yu M. Foong, Mahesh Uttamchandani, J. Vincent Edwards, Alfred D. French, Thomas Jacks, K. Rajasekaran, Peter Mergaert, Eva Kondorosi, Esther Badosa, Jordi Cabrefiga, Marta Planas, Lidia Feliu, Eduard Bardají, B. López-García, B. San Segundo, M. Coca, J. W. Cary, C. A. Chlan, J. M. Jaynes, D. Bhatnagar, Uma Shankar Sagaram, Jagdeep Kaur, Dilip Shah, Jose F. Marcos, Mónica Gandía, Eleonora Harries, Lourdes Carmona, Alberto Muñoz, Jianming Fu, Minesh Patel, Anna Maria Nuutila, Ron Skadsen, Luis C. Mejía, Mark J. Guiltinan, Zi Shi, Lena Landherr, Siela N. Maximova, V. Sarojini, Svetlana Oard, Jong Hyun Ham, Marc Alan Cohn, Dmytro P. Yevtushenko, Santosh Misra, Kanniah Rajasekaran, Jeffrey W. Cary, Jesse M. Jaynes, Emilio Montesinos, Neeloffer Mookherjee, Leola N. Y. Chow, Robert E. W. Hancock, Gregory C. Bernard, J. M. Conlon, Ashley L. Hilchie, Melanie R. Power Coombs, David W. Hoskin, Clayton Yates, Timothy Turner, Zhe Yan, Wendy J. Hartsock, Zhaohui Qian, Kathryn V. Holmes, Robert S. Hodges, Rachna Shah, Theresa L. Chang, V. Siva Rami Reddy, Yu M. Foong, Mahesh Uttamchandani, J. Vincent Edwards, Alfred D. French, Thomas Jacks, K. Rajasekaran, Peter Mergaert, Eva Kondorosi, Esther Badosa, Jordi Cabrefiga, Marta Planas, Lidia Feliu, Eduard Bardají, B. López-García, B. San Segundo, M. Coca, J. W. Cary, C. A. Chlan, J. M. Jaynes, D. Bhatnagar, Uma Shankar Sagaram, Jagdeep Kaur, Dilip Shah, Jose F. Marcos, Mónica Gandía, Eleonora Harries, Lourdes Carmona, Alberto Muñoz, Jianming Fu, Minesh Patel, Anna Maria Nuutila, Ron Skadsen, Luis C. Mejía, Mark J. Guiltinan, Zi Shi, Lena Landherr, Siela N. Maximova, V. Sarojini, Svetlana Oard, Jong Hyun Ham, Marc Alan Cohn, Dmytro P. Yevtushenko, and Santosh Misra

Subjects
Plant diseases, Therapeutics, Anti-infective agents, Peptides--Therapeutic use, Peptide drugs
Published
2012

4. Cationic host defence peptides: multifaceted role in immune modulation and inflammation

Author

Ka-Yee Choi, Leola N Y Chow, and Neeloffer Mookherjee

Subjects
Inflammation, Innate immune system, Effector, Antimicrobial peptides, Molecular Sequence Data, Computational biology, Review, Biology, Acquired immune system, Cathelicidins, Immunomodulation, Immunity, Immunology, medicine, Immunology and Allergy, Animals, Humans, Immunologic Factors, Amino Acid Sequence, medicine.symptom, Transcription factor, Antimicrobial Cationic Peptides
Abstract

Host defence peptides (HDPs) are innate immune effector molecules found in diverse species. HDPs exhibit a wide range of functions ranging from direct antimicrobial properties to immunomodulatory effects. Research in the last decade has demonstrated that HDPs are critical effectors of both innate and adaptive immunity. Various studies have hypothesized that the antimicrobial property of certain HDPs may be largely due to their immunomodulatory functions. Mechanistic studies revealed that the role of HDPs in immunity is very complex and involves various receptors, signalling pathways and transcription factors. This review will focus on the multiple functions of HDPs in immunity and inflammation, with special reference to cathelicidins, e.g. LL-37, certain defensins and novel synthetic innate defence regulator peptides. We also discuss emerging concepts of specific HDPs in immune-mediated inflammatory diseases, including the potential use of cationic peptides as therapeutics for immune-mediated inflammatory disorders.

Published
2011

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