13 results on '"Leo, Mirco"'
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2. Health-related quality of life profiles, trajectories, persistent symptoms and pulmonary function one year after ICU discharge in invasively ventilated COVID-19 patients, a prospective follow-up study
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Tartaglione, Marco, Chiarini, Valentina, Buldini, Virginia, Coniglio, Carlo, Moro, Federico, Orlando, Silvia, Fecarotti, Daniele, Cilloni, Nicola, Giuntoli, Lorenzo, Bellocchio, Angela, Matteo, Emanuele, Pizzilli, Giacinto, Siniscalchi, Antonio, Tartivita, Chiara, Cavalli, Irene, Castelli, Andrea, Marchio, Annalisa, Bacchilega, Igor, Bernabé, Laura, Facondini, Francesca, Morini, Luca, Bissoni, Luca, Viola, Lorenzo, Meconi, Tommaso, Pavoni, Vittorio, Venni, Angelica, Pagni, Aline, Cleta, Patrizia Pompa, Cavagnino, Marco, Guzzo, Alessia, Malfatto, Anna, Adduci, Angelina, Pareschi, Silvia, Bertellini, Elisabetta, Maccieri, Jessica, Marinangeli, Elisa, Racca, Fabrizio, Verri, Marco, Falò, Giulia, Marangoni, Elisabetta, Ottaviani, Irene, Boni, Francesco, Felloni, Giulia, Baccarini, Federico Domenico, Terzitta, Marina, Maitan, Stefano, Tutino, Lorenzo, Senzi, Angelo, Consales, Guglielmo, Becherucci, Filippo, Imbriani, Michele, Orlandi, Paolo, Candini, Silvia, Golfieri, Rita, Ciccarese, Federica, Poerio, Antonio, Muratore, Francesco, Ferrari, Fabio, Mughetti, Martina, Giampalma, Emanuela, Franchini, Loredana, Neziri, Ersenad, Miceli, Marco, Minguzzi, Maria Teresa, Mellini, Lorenzo, Piciucchi, Sara, Monari, Matteo, Valli, Michele, Daniele, Federico, Ferioli, Martina, Nava, Stefano, Lazzari Agli, Luigi Arcangelo, Valentini, Ilaria, Bernardi, Eva, Balbi, Bruno, Contoli, Marco, Padovani, Marianna, Oldani, Stefano, Ravaglia, Claudia, Goti, Patrizio, Gamberini, Lorenzo, Mazzoli, Carlo Alberto, Prediletto, Irene, Sintonen, Harri, Scaramuzzo, Gaetano, Allegri, Davide, Colombo, Davide, Tonetti, Tommaso, Zani, Gianluca, Capozzi, Chiara, Dalpiaz, Giorgia, Agnoletti, Vanni, Cappellini, Iacopo, Melegari, Gabriele, Damiani, Federica, Fusari, Maurizio, Gordini, Giovanni, Laici, Cristiana, Lanza, Maria Concetta, Leo, Mirco, Marudi, Andrea, Papa, Raffaella, Potalivo, Antonella, Montomoli, Jonathan, Taddei, Stefania, Mazzolini, Massimiliano, Ferravante, Anna Filomena, Nicali, Roberta, Ranieri, Vito Marco, Russo, Emanuele, Volta, Carlo Alberto, and Spadaro, Savino
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- 2021
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3. Factors influencing liberation from mechanical ventilation in coronavirus disease 2019: multicenter observational study in fifteen Italian ICUs
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Gamberini, Lorenzo, Tonetti, Tommaso, Spadaro, Savino, Zani, Gianluca, Mazzoli, Carlo Alberto, Capozzi, Chiara, Giampalma, Emanuela, Bacchi Reggiani, Maria Letizia, Bertellini, Elisabetta, Castelli, Andrea, Cavalli, Irene, Colombo, Davide, Crimaldi, Federico, Damiani, Federica, Fogagnolo, Alberto, Fusari, Maurizio, Gamberini, Emiliano, Gordini, Giovanni, Laici, Cristiana, Lanza, Maria Concetta, Leo, Mirco, Marudi, Andrea, Nardi, Giuseppe, Ottaviani, Irene, Papa, Raffaella, Potalivo, Antonella, Russo, Emanuele, Taddei, Stefania, Volta, Carlo Alberto, and Ranieri, V. Marco
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- 2020
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4. A Review of DNA Data Storage Technologies Based on Biomolecules
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Teresa Santarelli Maria, Utreja Puneet, Marcela Pabon Ingrid, Malik Taqdees, Piccioni Andrea, Lemaire Claire, Zhou Murong, Naim Asma, Verma Shivani, Franceschi Francesco, Longhitano Yaroslava, Zanza Christian, Zhang Lichao, Xu Lei, Romenskaya Tatsiana, Leo Mirco, Lv Yuanyuan, Li Zongjin, and Racca Fabrizio
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chemistry.chemical_classification ,Computational Mathematics ,chemistry ,Biomolecule ,DNA digital data storage ,Genetics ,Nanotechnology ,Molecular Biology ,Biochemistry - Abstract
In the information age, data storage technology has become the key to improving computer systems. Since traditional storage technologies cannot meet the demand for massive storage, new DNA storage technology based on biomolecules attracts much attention. DNA storage refers to the technology that uses artificially synthesized deoxynucleotide chains to store and read all information, such as documents, pictures, and audio. First, data are encoded into binary number strings. Then, the four types of base, A(Adenine), T(Thymine), C(Cytosine), and G(Guanine), are used to encode the corresponding binary numbers so that the data can be used to construct the target DNA molecules in the form of deoxynucleotide chains. Subsequently, the corresponding DNA molecules are artificially synthesized, enabling the data to be stored within them. Compared with traditional storage systems, DNA storage has major advantages, such as high storage density, long duration, as well as low hardware cost, high access parallelism, and strong scalability, which satisfies the demands for big data storage. This manuscript first reviews the origin and development of DNA storage technology, then the storage principles, contents, and methods are introduced. Finally, the development of DNA storage technology is analyzed. From the initial research to the cutting edge of this field and beyond, the advantages, disadvantages, and practical applications of DNA storage technology require continuous exploration.
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- 2022
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5. Practical Review of Mechanical Ventilation in Adults and Children in the Operating Room and Emergency Department
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Zanza, Christian, primary, Longhitano, Yaroslava, additional, Leo, Mirco, additional, Romenskaya, Tatsiana, additional, Franceschi, Francesco, additional, Piccioni, Andrea, additional, Pabon, Ingrid M., additional, Santarelli, Maria T., additional, and Racca, Fabrizio, additional
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- 2022
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6. Single-Breath Counting Test Predicts Non-Invasive Respiratory Support Requirements in Patients with COVID-19 Pneumonia
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Longhitano, Yaroslava, primary, Zanza, Christian, additional, Romenskaya, Tatsiana, additional, Saviano, Angela, additional, Persiano, Tonia, additional, Leo, Mirco, additional, Piccioni, Andrea, additional, Betti, Marta, additional, Maconi, Antonio, additional, Pindinello, Ivano, additional, Boverio, Riccardo, additional, Rello, Jordi, additional, Franceschi, Francesco, additional, and Racca, Fabrizio, additional
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- 2021
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7. Health-related quality of life profiles, trajectories, persistent symptoms and pulmonary function one year after ICU discharge in invasively ventilated COVID-19 patients, a prospective follow-up study
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Gamberini, Lorenzo, primary, Mazzoli, Carlo Alberto, additional, Prediletto, Irene, additional, Sintonen, Harri, additional, Scaramuzzo, Gaetano, additional, Allegri, Davide, additional, Colombo, Davide, additional, Tonetti, Tommaso, additional, Zani, Gianluca, additional, Capozzi, Chiara, additional, Dalpiaz, Giorgia, additional, Agnoletti, Vanni, additional, Cappellini, Iacopo, additional, Melegari, Gabriele, additional, Damiani, Federica, additional, Fusari, Maurizio, additional, Gordini, Giovanni, additional, Laici, Cristiana, additional, Lanza, Maria Concetta, additional, Leo, Mirco, additional, Marudi, Andrea, additional, Papa, Raffaella, additional, Potalivo, Antonella, additional, Montomoli, Jonathan, additional, Taddei, Stefania, additional, Mazzolini, Massimiliano, additional, Ferravante, Anna Filomena, additional, Nicali, Roberta, additional, Ranieri, Vito Marco, additional, Russo, Emanuele, additional, Volta, Carlo Alberto, additional, Spadaro, Savino, additional, Tartaglione, Marco, additional, Chiarini, Valentina, additional, Buldini, Virginia, additional, Coniglio, Carlo, additional, Moro, Federico, additional, Orlando, Silvia, additional, Fecarotti, Daniele, additional, Cilloni, Nicola, additional, Giuntoli, Lorenzo, additional, Bellocchio, Angela, additional, Matteo, Emanuele, additional, Pizzilli, Giacinto, additional, Siniscalchi, Antonio, additional, Tartivita, Chiara, additional, Cavalli, Irene, additional, Castelli, Andrea, additional, Marchio, Annalisa, additional, Bacchilega, Igor, additional, Bernabé, Laura, additional, Facondini, Francesca, additional, Morini, Luca, additional, Bissoni, Luca, additional, Viola, Lorenzo, additional, Meconi, Tommaso, additional, Pavoni, Vittorio, additional, Venni, Angelica, additional, Pagni, Aline, additional, Cleta, Patrizia Pompa, additional, Cavagnino, Marco, additional, Guzzo, Alessia, additional, Malfatto, Anna, additional, Adduci, Angelina, additional, Pareschi, Silvia, additional, Bertellini, Elisabetta, additional, Maccieri, Jessica, additional, Marinangeli, Elisa, additional, Racca, Fabrizio, additional, Verri, Marco, additional, Falò, Giulia, additional, Marangoni, Elisabetta, additional, Ottaviani, Irene, additional, Boni, Francesco, additional, Felloni, Giulia, additional, Baccarini, Federico Domenico, additional, Terzitta, Marina, additional, Maitan, Stefano, additional, Tutino, Lorenzo, additional, Senzi, Angelo, additional, Consales, Guglielmo, additional, Becherucci, Filippo, additional, Imbriani, Michele, additional, Orlandi, Paolo, additional, Candini, Silvia, additional, Golfieri, Rita, additional, Ciccarese, Federica, additional, Poerio, Antonio, additional, Muratore, Francesco, additional, Ferrari, Fabio, additional, Mughetti, Martina, additional, Giampalma, Emanuela, additional, Franchini, Loredana, additional, Neziri, Ersenad, additional, Miceli, Marco, additional, Minguzzi, Maria Teresa, additional, Mellini, Lorenzo, additional, Piciucchi, Sara, additional, Monari, Matteo, additional, Valli, Michele, additional, Daniele, Federico, additional, Ferioli, Martina, additional, Nava, Stefano, additional, Lazzari Agli, Luigi Arcangelo, additional, Valentini, Ilaria, additional, Bernardi, Eva, additional, Balbi, Bruno, additional, Contoli, Marco, additional, Padovani, Marianna, additional, Oldani, Stefano, additional, Ravaglia, Claudia, additional, and Goti, Patrizio, additional
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- 2021
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8. Additional file 3 of Sustained oxygenation improvement after first prone positioning is associated with liberation from mechanical ventilation and mortality in critically ill COVID-19 patients: a cohort study
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Scaramuzzo, Gaetano, Gamberini, Lorenzo, Tonetti, Tommaso, Zani, Gianluca, Ottaviani, Irene, Mazzoli, Carlo Alberto, Capozzi, Chiara, Giampalma, Emanuela, Reggiani, Maria Letizia Bacchi, Bertellini, Elisabetta, Castelli, Andrea, Cavalli, Irene, Colombo, Davide, Crimaldi, Federico, Damiani, Federica, Fusari, Maurizio, Gamberini, Emiliano, Gordini, Giovanni, Laici, Cristiana, Lanza, Maria Concetta, Leo, Mirco, Marudi, Andrea, Nardi, Giuseppe, Papa, Raffaella, Potalivo, Antonella, Russo, Emanuele, Taddei, Stefania, Consales, Guglielmo, Cappellini, Iacopo, Ranieri, Vito Marco, Volta, Carlo Alberto, Guerin, Claude, and Spadaro, Savino
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Data_FILES ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) - Abstract
Additional file 3. ICU-RER collaborators list.
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- 2021
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9. Sustained Oxygenation Improvement After First Prone Positioning Is Associated with Liberation from Mechanical Ventilation and Survival in Critically Ill COVID-19 Patients: A Cohort Study
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Scaramuzzo, Gaetano, primary, Gamberini, Lorenzo, additional, Tonetti, Tommaso, additional, Zani, Gianluca, additional, Ottaviani, Irene, additional, Mazzoli, Carlo Alberto, additional, Capozzi, Chiara, additional, Giampalma, Emanuela, additional, Bacchi Reggiani, Maria Letizia, additional, Bertellini, Elisabetta, additional, Castelli, Andrea, additional, Cavalli, Irene, additional, Colombo, Davide, additional, Crimaldi, Federico, additional, Damiani, Federica, additional, Fusari, Maurizio, additional, Gamberini, Emiliano, additional, Gordini, Giovanni, additional, Laici, Cristiana, additional, Lanza, Maria Concetta, additional, Leo, Mirco, additional, Marudi, Andrea, additional, Nardi, Giuseppe, additional, Papa, Raffaella, additional, Potalivo, Antonella, additional, Russo, Emanuele, additional, Taddei, Stefania, additional, Consales, Guglielmo, additional, Cappellini, Iacopo, additional, Ranieri, Marco, additional, Volta, Carlo Alberto, additional, Guerin, Claude, additional, and Spadaro, Savino, additional
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- 2020
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10. Single-Breath Counting Test Predicts Non-Invasive Respiratory Support Requirements in Patients with COVID-19 Pneumonia.
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Longhitano, Yaroslava, Zanza, Christian, Romenskaya, Tatsiana, Saviano, Angela, Persiano, Tonia, Leo, Mirco, Piccioni, Andrea, Betti, Marta, Maconi, Antonio, Pindinello, Ivano, Boverio, Riccardo, Rello, Jordi, Franceschi, Francesco, and Racca, Fabrizio
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COVID-19 ,PNEUMONIA ,SYMPTOMS ,NEAR infrared spectroscopy ,CONTINUOUS positive airway pressure - Abstract
The use of non-invasive respiratory strategies (NIRS) is crucial to improve oxygenation in COVID-19 patients with hypoxemia refractory to conventional oxygen therapy. However, the absence of respiratory symptoms may delay the start of NIRS. The aim of this study was to determine whether a simple bedside test such as single-breath counting test (SBCT) can predict the need for NIRS in the 24 h following the access to Emergency Department (ED). We performed a prospective observational study on 120 patients with COVID-19 pneumonia. ROC curves were used to analyze factors which might predict NIRS requirement. We found that 36% of patients had normal respiratory rate and did not experience dyspnea at rest. 65% of study population required NIRS in the 24 h following the access to ED. NIRS-requiring group presented lower PaO
2 /FiO2 (235.09 vs. 299.02), SpO2 /FiO2 ratio (357.83 vs. 431.07), PaCO2 (35.12 vs. 40.08), and SBCT (24.46 vs. 30.36) and showed higher incidence of dyspnea at rest (57.7% vs. 28.6%). Furthermore, SBCT predicted NIRS requirement even in the subgroup of patients without respiratory symptoms (AUC = 0.882, cut-off = 30). SBCT might be a valuable tool for bedside assessment of respiratory function in patients with COVID-19 pneumonia and might be considered as an early clinical sign of impending respiratory deterioration. [ABSTRACT FROM AUTHOR]- Published
- 2022
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11. Factors influencing liberation from mechanical ventilation in coronavirus disease 2019: multicenter observational study in fifteen Italian ICUs
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Gamberini, L., Tonetti, T., Spadaro, S., Zani, G., Mazzoli, C. A., Capozzi, C., Giampalma, E., Bacchi Reggiani, M. L., Bertellini, E., Castelli, A., Cavalli, I., Colombo, D., Crimaldi, F., Damiani, F., Fogagnolo, A., Fusari, M., Gamberini, E., Gordini, G., Laici, C., Lanza, M. C., Leo, M., Marudi, A., Nardi, G., Ottaviani, I., Papa, R., Potalivo, A., Russo, E., Taddei, S., Volta, C. A., Ranieri, V. M., Tartaglione, M., Chiarini, V., Buldini, V., Coniglio, C., Moro, F., Cilloni, N., Giuntoli, L., Bellocchio, A., Matteo, E., Pizzilli, G., Siniscalchi, A., Tartivita, C., Matteo, F., Marchio, A., Bacchilega, I., Bernabe, L., Guarino, S., Mosconi, G., Bissoni, L., Viola, L., Meconi, T., Pavoni, V., Pagni, A., Pompacleta, P., Cavagnino, M., Malfatto, A., Adduci, A., Pareschi, S., Melegari, G., Maccieri, J., Marinangeli, E., Racca, F., Verri, M., Falo, G., Marangoni, E., Boni, F., Felloni, G., Baccarini, F. D., Terzitta, M., Maitan, S., Imbriani, M., Orlandi, P., Dalpiaz, G., Golfieri, R., Ciccarese, F., Poerio, A., Muratore, F., Ferrari, F., Mughetti, M., Franchini, L., Neziri, E., Miceli, M., Minguzzi, M. T., Mellini, L., Piciucchi, S., Gamberini, Lorenzo, Tonetti, Tommaso, Spadaro, Savino, Zani, Gianluca, Mazzoli, Carlo Alberto, Capozzi, Chiara, Giampalma, Emanuela, Bacchi Reggiani, Maria Letizia, Bertellini, Elisabetta, Castelli, Andrea, Cavalli, Irene, Colombo, Davide, Crimaldi, Federico, Damiani, Federica, Fogagnolo, Alberto, Fusari, Maurizio, Gamberini, Emiliano, Gordini, Giovanni, Laici, Cristiana, Lanza, Maria Concetta, Leo, Mirco, Marudi, Andrea, Nardi, Giuseppe, Ottaviani, Irene, Papa, Raffaella, Potalivo, Antonella, Russo, Emanuele, Taddei, Stefania, Volta, Carlo Alberto, and Ranieri, V Marco
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medicine.medical_specialty ,ARDS ,medicine.medical_treatment ,artificial ,Outcomes ,Critical Care and Intensive Care Medicine ,law.invention ,NO ,03 medical and health sciences ,0302 clinical medicine ,Mechanical ventilation ,law ,Coronavirus disease 2019 ,Intensive care ,Outcomes, mortality ,Respiration, artificial ,medicine ,030212 general & internal medicine ,Renal replacement therapy ,business.industry ,Research ,Respiration ,Organ dysfunction ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,030208 emergency & critical care medicine ,lcsh:RC86-88.9 ,medicine.disease ,Intensive care unit ,mortality ,Respiratory failure ,Emergency medicine ,SOFA score ,medicine.symptom ,business - Abstract
Background A large proportion of patients with coronavirus disease 2019 (COVID-19) develop severe respiratory failure requiring admission to the intensive care unit (ICU) and about 80% of them need mechanical ventilation (MV). These patients show great complexity due to multiple organ involvement and a dynamic evolution over time; moreover, few information is available about the risk factors that may contribute to increase the time course of mechanical ventilation. The primary objective of this study is to investigate the risk factors associated with the inability to liberate COVID-19 patients from mechanical ventilation. Due to the complex evolution of the disease, we analyzed both pulmonary variables and occurrence of non-pulmonary complications during mechanical ventilation. The secondary objective of this study was the evaluation of risk factors for ICU mortality. Methods This multicenter prospective observational study enrolled 391 patients from fifteen COVID-19 dedicated Italian ICUs which underwent invasive mechanical ventilation for COVID-19 pneumonia. Clinical and laboratory data, ventilator parameters, occurrence of organ dysfunction, and outcome were recorded. The primary outcome measure was 28 days ventilator-free days and the liberation from MV at 28 days was studied by performing a competing risks regression model on data, according to the method of Fine and Gray; the event death was considered as a competing risk. Results Liberation from mechanical ventilation was achieved in 53.2% of the patients (208/391). Competing risks analysis, considering death as a competing event, demonstrated a decreased sub-hazard ratio for liberation from mechanical ventilation (MV) with increasing age and SOFA score at ICU admission, low values of PaO2/FiO2 ratio during the first 5 days of MV, respiratory system compliance (CRS) lower than 40 mL/cmH2O during the first 5 days of MV, need for renal replacement therapy (RRT), late-onset ventilator-associated pneumonia (VAP), and cardiovascular complications. ICU mortality during the observation period was 36.1% (141/391). Similar results were obtained by the multivariate logistic regression analysis using mortality as a dependent variable. Conclusions Age, SOFA score at ICU admission, CRS, PaO2/FiO2, renal and cardiovascular complications, and late-onset VAP were all independent risk factors for prolonged mechanical ventilation in patients with COVID-19. Trial registration NCT04411459
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- 2020
12. Sustained oxygenation improvement after first prone positioning is associated with liberation from mechanical ventilation and mortality in critically ill COVID-19 patients: a cohort study.
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Scaramuzzo G, Gamberini L, Tonetti T, Zani G, Ottaviani I, Mazzoli CA, Capozzi C, Giampalma E, Bacchi Reggiani ML, Bertellini E, Castelli A, Cavalli I, Colombo D, Crimaldi F, Damiani F, Fusari M, Gamberini E, Gordini G, Laici C, Lanza MC, Leo M, Marudi A, Nardi G, Papa R, Potalivo A, Russo E, Taddei S, Consales G, Cappellini I, Ranieri VM, Volta CA, Guerin C, and Spadaro S
- Abstract
Background: Prone positioning (PP) has been used to improve oxygenation in patients affected by the SARS-CoV-2 disease (COVID-19). Several mechanisms, including lung recruitment and better lung ventilation/perfusion matching, make a relevant rational for using PP. However, not all patients maintain the oxygenation improvement after returning to supine position. Nevertheless, no evidence exists that a sustained oxygenation response after PP is associated to outcome in mechanically ventilated COVID-19 patients. We analyzed data from 191 patients affected by COVID-19-related acute respiratory distress syndrome undergoing PP for clinical reasons. Clinical history, severity scores and respiratory mechanics were analyzed. Patients were classified as responders (≥ median PaO
2 /FiO2 variation) or non-responders (< median PaO2 /FiO2 variation) based on the PaO2 /FiO2 percentage change between pre-proning and 1 to 3 h after re-supination in the first prone positioning session. Differences among the groups in physiological variables, complication rates and outcome were evaluated. A competing risk regression analysis was conducted to evaluate if PaO2 /FiO2 response after the first pronation cycle was associated to liberation from mechanical ventilation., Results: The median PaO2 /FiO2 variation after the first PP cycle was 49 [19-100%] and no differences were found in demographics, comorbidities, ventilatory treatment and PaO2 /FiO2 before PP between responders (96/191) and non-responders (95/191). Despite no differences in ICU length of stay, non-responders had a higher rate of tracheostomy (70.5% vs 47.9, P = 0.008) and mortality (53.7% vs 33.3%, P = 0.006), as compared to responders. Moreover, oxygenation response after the first PP was independently associated to liberation from mechanical ventilation at 28 days and was increasingly higher being higher the oxygenation response to PP., Conclusions: Sustained oxygenation improvement after first PP session is independently associated to improved survival and reduced duration of mechanical ventilation in critically ill COVID-19 patients.- Published
- 2021
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13. Correction to: Factors influencing liberation from mechanical ventilation in coronavirus disease 2019: multicenter observational study in fifteen Italian ICUs.
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Gamberini L, Tonetti T, Spadaro S, Zani G, Mazzoli CA, Capozzi C, Giampalma E, Reggiani MLB, Bertellini E, Castelli A, Cavalli I, Colombo D, Crimaldi F, Damiani F, Fogagnolo A, Fusari M, Gamberini E, Gordini G, Laici C, Lanza MC, Leo M, Marudi A, Nardi G, Ottaviani I, Papa R, Potalivo A, Russo E, Taddei S, Volta CA, and Ranieri VM
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- 2020
- Full Text
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