22 results on '"Leo, Milena Di"'
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2. Endoscopic ultrasound-guided ablation of solid pancreatic lesions: A systematic review of early outcomes with pooled analysis
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Spadaccini, Marco, primary, Leo, Milena Di, additional, Iannone, Andrea, additional, Hoff, Daan von den, additional, Fugazza, Alessandro, additional, Galtieri, Piera Alessia, additional, Pellegatta, Gaia, additional, Maselli, Roberta, additional, Anderloni, Andrea, additional, Colombo, Matteo, additional, Siersema, Peter D, additional, Carrara, Silvia, additional, and Repici, Alessandro, additional
- Published
- 2022
- Full Text
- View/download PDF
3. Supplemental material for Endoscopic papillectomy for neoplastic ampullary lesions: A systematic review with pooled analysis
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Spadaccini, Marco, Fugazza, Alessandro, Frazzoni, Leonardo, Leo, Milena Di, Auriemma, Francesco, Carrara, Silvia, Maselli, Roberta, Galtieri, Piera Alessia, Viveksandeep Thoguluva Chandrasekar, Fuccio, Lorenzo, Aljahdli, Emad, Hassan, Cesare, Prateek Sharma, Anderloni, Andrea, and Repici, Alessandro
- Subjects
FOS: Clinical medicine ,FOS: Biological sciences ,111199 Nutrition and Dietetics not elsewhere classified ,FOS: Health sciences ,110308 Geriatrics and Gerontology ,69999 Biological Sciences not elsewhere classified ,111299 Oncology and Carcinogenesis not elsewhere classified - Abstract
Supplemental Material for Endoscopic papillectomy for neoplastic ampullary lesions: A systematic review with pooled analysis by Marco Spadaccini, Alessandro Fugazza, Leonardo Frazzoni, Milena Di Leo, Francesco Auriemma, Silvia Carrara, Roberta Maselli, Piera Alessia Galtieri, Viveksandeep Thoguluva Chandrasekar, Lorenzo Fuccio, Emad Aljahdli, Cesare Hassan, Prateek Sharma, Andrea Anderloni and Alessandro Repici in United European Gastroenterology Journal
- Published
- 2020
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4. A Ghost Behind the Rectum: Extramedullary Hematopoiesis Diagnosed by Endoscopic Ultrasound Fine Needle Biopsy
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Rahal Daoud, Repici Alessandro, Fugazza Alessandro, Leo Milena Di, and Carrara Silvia
- Subjects
Endoscopic ultrasound ,medicine.medical_specialty ,medicine.anatomical_structure ,medicine.diagnostic_test ,business.industry ,Automotive Engineering ,Medicine ,Rectum ,Radiology ,business ,medicine.disease ,Fine needle biopsy ,Extramedullary hematopoiesis - Published
- 2019
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5. What should be known prior to performing EUS exams?:(Part II)
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Dietrich, Christoph F, Arcidiacono, Paolo Giorgio, Braden, Barbara, Burmeister, Sean, Carrara, Silvia, Cui, Xinwu, Leo, Milena Di, Dong, Yi, Fusaroli, Pietro, Gottschalk, Uwe, Healey, Andrew J, Hocke, Michael, Hollerbach, Stephan, Garcia, Julio Iglesias, Ignee, André, Jürgensen, Christian, Kahaleh, Michel, Kitano, Masayuki, Kunda, Rastislav, Larghi, Alberto, Möller, Kathleen, Napoleon, Bertrand, Oppong, Kofi W, Petrone, Maria Chiara, Saftoiu, Adrian, Puri, Rajesh, Sahai, Anand V, Santo, Erwin, Sharma, Malay, Soweid, Assaad, Sun, Siyu, Bun Teoh, Anthony Yuen, Vilmann, Peter, Seifert, Hans, Jenssen, Christian, Dietrich, Christoph F, Arcidiacono, Paolo Giorgio, Braden, Barbara, Burmeister, Sean, Carrara, Silvia, Cui, Xinwu, Leo, Milena Di, Dong, Yi, Fusaroli, Pietro, Gottschalk, Uwe, Healey, Andrew J, Hocke, Michael, Hollerbach, Stephan, Garcia, Julio Iglesias, Ignee, André, Jürgensen, Christian, Kahaleh, Michel, Kitano, Masayuki, Kunda, Rastislav, Larghi, Alberto, Möller, Kathleen, Napoleon, Bertrand, Oppong, Kofi W, Petrone, Maria Chiara, Saftoiu, Adrian, Puri, Rajesh, Sahai, Anand V, Santo, Erwin, Sharma, Malay, Soweid, Assaad, Sun, Siyu, Bun Teoh, Anthony Yuen, Vilmann, Peter, Seifert, Hans, and Jenssen, Christian
- Abstract
In "What should be known prior to performing EUS exams, Part I," the authors discussed the need for clinical information and whether other imaging modalities are required before embarking EUS examinations. Herewith, we present part II which addresses some (technical) controversies how EUS is performed and discuss from different points of view providing the relevant evidence as available. (1) Does equipment design influence the complication rate? (2) Should we have a standardized screen orientation? (3) Radial EUS versus longitudinal (linear) EUS. (4) Should we search for incidental findings using EUS?
- Published
- 2019
6. Associations between pancreatic expression quantitative traits and risk of pancreatic ductal adenocarcinoma.
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Pistoni, Laura, Gentiluomo, Manuel, Lu, Ye, Maturana, Evangelina López de, Hlavac, Viktor, Vanella, Giuseppe, Darvasi, Erika, Milanetto, Anna Caterina, Oliverius, Martin, Vashist, Yogesh, Leo, Milena Di, Mohelnikova-Duchonova, Beatrice, Talar-Wojnarowska, Renata, Gheorghe, Cristian, Petrone, Maria Chiara, Strobel, Oliver, Arcidiacono, Paolo Giorgio, Vodickova, Ludmila, Szentesi, Andrea, and Capurso, Gabriele
- Subjects
GENETIC variation ,GENOME-wide association studies ,SINGLE nucleotide polymorphisms ,PANCREATIC tumors ,GENE expression ,PROGNOSIS ,PANCREATIC enzymes - Abstract
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Its poor prognosis is predominantly due to the fact that most patients remain asymptomatic until the disease reaches an advanced stage, alongside the lack of early markers and screening strategies. A better understanding of PDAC risk factors is essential for the identification of groups at high risk in the population. Genome-wide association studies (GWAS) have been a powerful tool for detecting genetic variants associated with complex traits, including pancreatic cancer. By exploiting functional and GWAS data, we investigated the associations between polymorphisms affecting gene function in the pancreas (expression quantitative trait loci, eQTLs) and PDAC risk. In a two-phase approach, we analysed 13 713 PDAC cases and 43 784 controls and identified a genome-wide significant association between the A allele of the rs2035875 polymorphism and increased PDAC risk (P = 7.14 × 10
−10 ). This allele is known to be associated with increased expression in the pancreas of the keratin genes KRT8 and KRT18 , whose increased levels have been reported to correlate with various tumour cell characteristics. Additionally, the A allele of the rs789744 variant was associated with decreased risk of developing PDAC (P = 3.56 × 10–6 ). This single nucleotide polymorphism is situated in the SRGAP1 gene and the A allele is associated with higher expression of the gene, which in turn inactivates the cyclin-dependent protein 42 (CDC42) gene expression, thus decreasing the risk of PDAC. In conclusion, we present here a functional-based novel PDAC risk locus and an additional strong candidate supported by significant associations and plausible biological mechanisms. [ABSTRACT FROM AUTHOR]- Published
- 2021
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7. Colorectal cancer screening from 45 years of age: Thesis, antithesis and synthesis
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Mannucci, Alessandro, primary, Zuppardo, Raffaella Alessia, additional, Rosati, Riccardo, additional, Leo, Milena Di, additional, Perea, José, additional, and Cavestro, Giulia Martina, additional
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- 2019
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8. Tu1671 – Small Bowel Neoplasia Detection in Lynch Syndrome Using Video Capsule Endoscopy
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Zuppardo, Raffaella Alessia, primary, Contaldo, Antonella, additional, Notaristefano, Chiara, additional, Leo, Milena Di, additional, Principi, Mariabeatrice, additional, Mannucci, Alessandro, additional, Rizzi, Salvatore, additional, Patricelli, Maria Grazia, additional, Raucci, Annalisa Russo, additional, Testoni, Pier Alberto, additional, Leo, Alfredo Di, additional, and Cavestro, Giulia M., additional
- Published
- 2019
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9. Tu1670 – Exogenous and Endogenous Associated Factors to Early Onset Colorectal Cancer
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Zuppardo, Raffaella Alessia, primary, Leo, Milena Di, additional, Mannucci, Alessandro, additional, Antoci, Graziana, additional, Azzolini, Francesco, additional, Esposito, Dario, additional, Fanti, Lorella, additional, Mazzoleni, Giorgia, additional, Notaristefano, Chiara, additional, Viale, Edi, additional, Rosati, Riccardo, additional, Testoni, Pier Alberto, additional, and Cavestro, Giulia M., additional
- Published
- 2019
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10. Sa1207 – The Effect of a Medical Device Containing Hyaluronic Acid, Chondroitin Sulfate and Aluminum Hydroxide Combined with Acid Suppression in the Treatment of the Extraesophageal Symptoms of Gastroesophageal Reflux Disease: Preliminary Data from a Prospective, Parallel-Group Randomized Controlled Study
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Pellegatta, Gaia, primary, Semeraro, Rossella, additional, Mangiavillano, Benedetto, additional, Auriemma, Francesco, additional, Cappello, Annalisa, additional, D'Amico, Ferdinando, additional, Finati, Elena, additional, Ferrara, Elisa Chiara, additional, Maselli, Roberta, additional, Leo, Milena Di, additional, Fugazza, Alessandro, additional, Galtieri, Piera Alessia, additional, Belletrutti, Paul J., additional, Carrara, Silvia, additional, Anderloni, Andrea A., additional, and Repici, Alessandro, additional
- Published
- 2019
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11. Early and Late Onset Colorectal Cancer Clinical Features: A Case-Control Study and Multivariate Analysis
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Leo, Milena Di, primary, Mannucci, Alessandro, additional, Zuppardo, Raffaella Alessia, additional, Antoci, Graziana, additional, Ditonno, Ilaria, additional, Raucci, Annalisa Russo, additional, Patricelli, Maria Grazia, additional, Elmore, Ugo, additional, Tamburini, Andrea Marco, additional, Azzolini, Francesco, additional, Esposito, Dario, additional, Fanti, Lorella, additional, Notaristefano, Chiara, additional, Viale, Edi, additional, Testoni, Pier Alberto, additional, Perea, Josè, additional, Rosati, Riccardo, additional, and Cavestro, Giulia, additional
- Published
- 2019
- Full Text
- View/download PDF
12. Genome-wide association study identifies inversion in theCTRB1-CTRB2locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
- Author
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Rosendahl, Jona, Kirsten, Holger, Hegyi, Eszter, Kovacs, Peter, Weiss, Frank Ulrich, Laumen, Helmut, Lichtner, Peter, Ruffert, Claudia, Chen, Jian-Min, Masson, Emmanuelle, Beer, Sebastian, Zimmer, Constantin, Seltsam, Katharina, Algül, Hana, Bühler, Florence, Bruno, Marco J, Bugert, Peter, Burkhardt, Ralph, Cavestro, Giulia Martina, Cichoz-Lach, Halina, Farré, Antoni, Frank, Josef, Gambaro, Giovanni, Gimpfl, Sebastian, Grallert, Harald, Griesmann, Heidi, Grützmann, Robert, Hellerbrand, Clau, Hegyi, Péter, Hollenbach, Marcu, Iordache, Sevastitia, Jurkowska, Grazyna, Keim, Volker, Kiefer, Falk, Krug, Sebastian, Landt, Olfert, Leo, Milena Di, Lerch, Markus M, Lévy, Philippe, Löffler, Marku, Löhr, Matthia, Ludwig, Maren, Macek, Milan, Malats, Nuria, Malecka-Panas, Ewa, Malerba, Giovanni, Mann, Karl, Mayerle, Julia, Mohr, Sonja, Te Morsche, Rene H M, Motyka, Marie, Mueller, Sebastian, Müller, Thoma, Nöthen, Markus M, Pedrazzoli, Sergio, Pereira, Stephen P, Peters, Annette, Pfützer, Roland, Real, Francisco X, Rebours, Vinciane, Ridinger, Monika, Rietschel, Marcella, Rösmann, Eva, Saftoiu, Adrian, Schneider, Alexander, Schulz, Hans-Ulrich, Soranzo, Nicole, Soyka, Michael, Simon, Peter, Skipworth, Jame, Stickel, Felix, Strauch, Konstantin, Stumvoll, Michael, Testoni, Pier Alberto, Tönjes, Anke, Werner, Lena, Werner, Jen, Wodarz, Norbert, Ziegler, Martin, Masamune, Atsushi, Mössner, Joachim, Férec, Claude, Michl, Patrick, P H Drenth, Joost, Witt, Heiko, Scholz, Marku, Sahin-Tóth, Miklós, Gambaro, Giovanni (ORCID:0000-0001-5733-2370), Rosendahl, Jona, Kirsten, Holger, Hegyi, Eszter, Kovacs, Peter, Weiss, Frank Ulrich, Laumen, Helmut, Lichtner, Peter, Ruffert, Claudia, Chen, Jian-Min, Masson, Emmanuelle, Beer, Sebastian, Zimmer, Constantin, Seltsam, Katharina, Algül, Hana, Bühler, Florence, Bruno, Marco J, Bugert, Peter, Burkhardt, Ralph, Cavestro, Giulia Martina, Cichoz-Lach, Halina, Farré, Antoni, Frank, Josef, Gambaro, Giovanni, Gimpfl, Sebastian, Grallert, Harald, Griesmann, Heidi, Grützmann, Robert, Hellerbrand, Clau, Hegyi, Péter, Hollenbach, Marcu, Iordache, Sevastitia, Jurkowska, Grazyna, Keim, Volker, Kiefer, Falk, Krug, Sebastian, Landt, Olfert, Leo, Milena Di, Lerch, Markus M, Lévy, Philippe, Löffler, Marku, Löhr, Matthia, Ludwig, Maren, Macek, Milan, Malats, Nuria, Malecka-Panas, Ewa, Malerba, Giovanni, Mann, Karl, Mayerle, Julia, Mohr, Sonja, Te Morsche, Rene H M, Motyka, Marie, Mueller, Sebastian, Müller, Thoma, Nöthen, Markus M, Pedrazzoli, Sergio, Pereira, Stephen P, Peters, Annette, Pfützer, Roland, Real, Francisco X, Rebours, Vinciane, Ridinger, Monika, Rietschel, Marcella, Rösmann, Eva, Saftoiu, Adrian, Schneider, Alexander, Schulz, Hans-Ulrich, Soranzo, Nicole, Soyka, Michael, Simon, Peter, Skipworth, Jame, Stickel, Felix, Strauch, Konstantin, Stumvoll, Michael, Testoni, Pier Alberto, Tönjes, Anke, Werner, Lena, Werner, Jen, Wodarz, Norbert, Ziegler, Martin, Masamune, Atsushi, Mössner, Joachim, Férec, Claude, Michl, Patrick, P H Drenth, Joost, Witt, Heiko, Scholz, Marku, Sahin-Tóth, Miklós, and Gambaro, Giovanni (ORCID:0000-0001-5733-2370)
- Abstract
OBJECTIVE: Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus. DESIGN: 1959 European alcoholic CP patients and population-based controls from the KORA, LIFE and INCIPE studies (n=4708) as well as chronic alcoholics from the GESGA consortium (n=1332) were screened with Illumina technology. For replication, three European cohorts comprising 1650 patients with non-alcoholic CP and 6695 controls originating from the same countries were used. RESULTS: We replicated previously reported risk loci CLDN2-MORC4, CTRC, PRSS1-PRSS2 and SPINK1 in alcoholic CP patients. We identified CTRB1-CTRB2 (chymotrypsin B1 and B2) as a new risk locus with lead single-nucleotide polymorphism (SNP) rs8055167 (OR 1.35, 95% CI 1.23 to 1.6). We found that a 16.6 kb inversion in the CTRB1-CTRB2 locus was in linkage disequilibrium with the CP-associated SNPs and was best tagged by rs8048956. The association was replicated in three independent European non-alcoholic CP cohorts of 1650 patients and 6695 controls (OR 1.62, 95% CI 1.42 to 1.86). The inversion changes the expression ratio of the CTRB1 and CTRB2 isoforms and thereby affects protective trypsinogen degradation and ultimately pancreatitis risk. CONCLUSION: An inversion in the CTRB1-CTRB2 locus modifies risk for alcoholic and non-alcoholic CP indicating that common pathomechanisms are involved in these inflammatory disorders.
- Published
- 2017
13. Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
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Rosendahl, Jonas, primary, Kirsten, Holger, additional, Hegyi, Eszter, additional, Kovacs, Peter, additional, Weiss, Frank Ulrich, additional, Laumen, Helmut, additional, Lichtner, Peter, additional, Ruffert, Claudia, additional, Chen, Jian-Min, additional, Masson, Emmanuelle, additional, Beer, Sebastian, additional, Zimmer, Constantin, additional, Seltsam, Katharina, additional, Algül, Hana, additional, Bühler, Florence, additional, Bruno, Marco J, additional, Bugert, Peter, additional, Burkhardt, Ralph, additional, Cavestro, Giulia Martina, additional, Cichoz-Lach, Halina, additional, Farré, Antoni, additional, Frank, Josef, additional, Gambaro, Giovanni, additional, Gimpfl, Sebastian, additional, Grallert, Harald, additional, Griesmann, Heidi, additional, Grützmann, Robert, additional, Hellerbrand, Claus, additional, Hegyi, Péter, additional, Hollenbach, Marcus, additional, Iordache, Sevastitia, additional, Jurkowska, Grazyna, additional, Keim, Volker, additional, Kiefer, Falk, additional, Krug, Sebastian, additional, Landt, Olfert, additional, Leo, Milena Di, additional, Lerch, Markus M, additional, Lévy, Philippe, additional, Löffler, Markus, additional, Löhr, Matthias, additional, Ludwig, Maren, additional, Macek, Milan, additional, Malats, Nuria, additional, Malecka-Panas, Ewa, additional, Malerba, Giovanni, additional, Mann, Karl, additional, Mayerle, Julia, additional, Mohr, Sonja, additional, te Morsche, Rene H M, additional, Motyka, Marie, additional, Mueller, Sebastian, additional, Müller, Thomas, additional, Nöthen, Markus M, additional, Pedrazzoli, Sergio, additional, Pereira, Stephen P, additional, Peters, Annette, additional, Pfützer, Roland, additional, Real, Francisco X, additional, Rebours, Vinciane, additional, Ridinger, Monika, additional, Rietschel, Marcella, additional, Rösmann, Eva, additional, Saftoiu, Adrian, additional, Schneider, Alexander, additional, Schulz, Hans-Ulrich, additional, Soranzo, Nicole, additional, Soyka, Michael, additional, Simon, Peter, additional, Skipworth, James, additional, Stickel, Felix, additional, Strauch, Konstantin, additional, Stumvoll, Michael, additional, Testoni, Pier Alberto, additional, Tönjes, Anke, additional, Werner, Lena, additional, Werner, Jens, additional, Wodarz, Norbert, additional, Ziegler, Martin, additional, Masamune, Atsushi, additional, Mössner, Joachim, additional, Férec, Claude, additional, Michl, Patrick, additional, P H Drenth, Joost, additional, Witt, Heiko, additional, Scholz, Markus, additional, and Sahin-Tóth, Miklós, additional
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- 2017
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14. Endoscopic papillectomy for neoplastic ampullary lesions: A systematic review with pooled analysis
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Spadaccini, Marco, Fugazza, Alessandro, Frazzoni, Leonardo, Leo, Milena Di, Auriemma, Francesco, Carrara, Silvia, Maselli, Roberta, Galtieri, Piera Alessia, Chandrasekar, Viveksandeep Thoguluva, Fuccio, Lorenzo, Aljahdli, Emad, Hassan, Cesare, Sharma, Prateek, Anderloni, Andrea, and Repici, Alessandro
- Abstract
Endoscopic papillectomy (EP) is a viable therapy in ampullary lesions (AL). Many series have reported low morbidity and acceptable outcomes. We performed a systematic review with pooled analysis to assess the safety and efficacy of EP for AL. Electronic databases (Medline, Scopus and EMBASE) were searched up to September 2018. Studies that included patients with endoscopically resected AL were eligible. The rate of adverse events (AEs; primary outcome) and the rates of both technical and clinical efficacy outcomes were pooled by means of a random- or fixed-effects model to obtain a proportion with a 95% confidence interval (CI). Twenty-nine studies were included (1751 patients). The overall AE rate was 24.9%. The post-procedural pancreatitis rate was 11.9%, with the only factor affecting this outcome being prophylactic pancreatic stenting. The complete resection rate was 94.2%, with a rate of oncologically curative resection of 87.1%. The recurrence rate was 11.8% (follow-up: 9.6–84.5 months). EP is a relatively safe and effective option for AL. Our study might definitively suggest the protective role of prophylactic pancreatic stenting against post-procedural pancreatitis.
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- 2020
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15. Sa1256 Surveillance of Barrett's Esophagus Post Ablation: Is It Better to Use Jumbo Over Standard Biopsy Forceps?
- Author
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Vennelaganti, Sreekar, primary, Vennalaganti, Prashanth, additional, Duvvuri, Abhiram, additional, Lim, Diego, additional, Jani, Bhairvi, additional, Repici, Alessandro, additional, Ciscato, Camilla, additional, Spaggiari, Paola, additional, Consolo, Pierluigi, additional, Leo, Milena Di, additional, Mathur, Sharad, additional, Porter, Jaime, additional, Ferrara, Elisa, additional, Kennedy, Kevin, additional, Gupta, Neil, additional, and Sharma, Prateek, additional
- Published
- 2016
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16. Genome-wide association study identifies inversion in the CTRB1-CTRB2locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
- Author
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Rosendahl, Jonas, Kirsten, Holger, Hegyi, Eszter, Kovacs, Peter, Weiss, Frank Ulrich, Laumen, Helmut, Lichtner, Peter, Ruffert, Claudia, Chen, Jian-Min, Masson, Emmanuelle, Beer, Sebastian, Zimmer, Constantin, Seltsam, Katharina, Algul, Hana, Buhler, Florence, Bruno, Marco J, Bugert, Peter, Burkhardt, Ralph, Cavestro, Giulia Martina, Cichoz-Lach, Halina, Farré, Antoni, Frank, Josef, Gambaro, Giovanni, Gimpfl, Sebastian, Grallert, Harald, Griesmann, Heidi, Grutzmann, Robert, Hellerbrand, Claus, Hegyi, Pééter, Hollenbach, Marcus, Iordache, Sevastitia, Jurkowska, Grazyna, Keim, Volker, Kiefer, Falk, Krug, Sebastian, Landt, Olfert, Leo, Milena Di, Lerch, Markus M, Lééévy, Philippe, Loffler, Markus, Lohr, Matthias, Ludwig, Maren, Macek, Milan, Malats, Nuria, Malecka-Panas, Ewa, Malerba, Giovanni, Mann, Karl, Mayerle, Julia, Mohr, Sonja, te Morsche, Rene H M, Motyka, Marie, Mueller, Sebastian, Muller, Thomas, Nothen, Markus M, Pedrazzoli, Sergio, Pereira, Stephen P, Peters, Annette, Pfutzer, Roland, Real, Francisco X, Rebours, Vinciane, Ridinger, Monika, Rietschel, Marcella, Rosmann, Eva, Saftoiu, Adrian, Schneider, Alexander, Schulz, Hans-Ulrich, Soranzo, Nicole, Soyka, Michael, Simon, Peter, Skipworth, James, Stickel, Felix, Strauch, Konstantin, Stumvoll, Michael, Testoni, Pier Alberto, Tonjes, Anke, Werner, Lena, Werner, Jens, Wodarz, Norbert, Ziegler, Martin, Masamune, Atsushi, Mossner, Joachim, Féééérec, Claude, Michl, Patrick, P H Drenth, Joost, Witt, Heiko, Scholz, Markus, and Sahin-Tééééóóth, Miklééééós
- Abstract
ObjectiveAlcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus.Design1959 European alcoholic CP patients and population-based controls from the KORA, LIFE and INCIPE studies (n=4708) as well as chronic alcoholics from the GESGA consortium (n=1332) were screened with Illumina technology. For replication, three European cohorts comprising 1650 patients with non-alcoholic CP and 6695 controls originating from the same countries were used.ResultsWe replicated previously reported risk loci CLDN2-MORC4, CTRC, PRSS1-PRSS2and SPINK1in alcoholic CP patients. We identified CTRB1-CTRB2(chymotrypsin B1 and B2) as a new risk locus with lead single-nucleotide polymorphism (SNP) rs8055167(OR 1.35, 95% CI 1.23 to 1.6). We found that a 16.6 kb inversion in the CTRB1-CTRB2locus was in linkage disequilibrium with the CP-associated SNPs and was best tagged by rs8048956. The association was replicated in three independent European non-alcoholic CP cohorts of 1650 patients and 6695 controls (OR 1.62, 95% CI 1.42 to 1.86). The inversion changes the expression ratio of the CTRB1 and CTRB2 isoforms and thereby affects protective trypsinogen degradation and ultimately pancreatitis risk.ConclusionAn inversion in the CTRB1-CTRB2locus modifies risk for alcoholic and non-alcoholic CP indicating that common pathomechanisms are involved in these inflammatory disorders.
- Published
- 2018
- Full Text
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17. Fetal radiation exposure: Is monitoring really needed?
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Leo, Milena Di, primary
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- 2013
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18. Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
- Author
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James R. A. Skipworth, Sebastian Krug, Florence Bühler, Sebastian Gimpfl, Joachim Mössner, Anke Tönjes, Atsushi Masamune, Adrian Saftoiu, Roland H. Pfützer, Marcella Rietschel, Heiko Witt, Felix Stickel, Jens Werner, Peter Kovacs, Nicole Soranzo, Constantin Zimmer, Martin Ziegler, Helmut Laumen, Holger Kirsten, Marco J. Bruno, Joost P.H. Drenth, Markus M. Lerch, Markus M. Nöthen, Claus Hellerbrand, Annette Peters, Philippe Lévy, Jian-Min Chen, Monika Ridinger, Giulia Martina Cavestro, Emmanuelle Masson, Milena Di Leo, Peter Simon, Peter Bugert, Péter Hegyi, Karl Mann, Miklós Sahin-Tóth, Pier Alberto Testoni, Núria Malats, Rene H. M. te Morsche, Konstantin Strauch, Stephen P. Pereira, Josef Frank, Norbert Wodarz, Halina Cichoż-Lach, Jonas Rosendahl, Alexander Schneider, Marcus Hollenbach, Olfert Landt, Markus Löffler, Sergio Pedrazzoli, Volker Keim, Matthias Löhr, Marie Motyka, Sebastian Mueller, Ralph Burkhardt, Antoni Farré, Heidi Griesmann, Falk Kiefer, Giovanni Malerba, Claudia Ruffert, Markus Scholz, Francisco X. Real, Maren Ludwig, Eszter Hegyi, Harald Grallert, Hana Algül, Vinciane Rebours, Eva Rösmann, Frank Ulrich Weiss, Sonja Mohr, Robert Grützmann, Sevastitia Iordache, Michael Soyka, Milan Macek, Peter Lichtner, Patrick Michl, Claude Férec, Giovanni Gambaro, Michael Stumvoll, Katharina Seltsam, Thomas Müller, Grazyna Jurkowska, Ewa Małecka-Panas, Sebastian Beer, Julia Mayerle, Hans-Ulrich Schulz, Lena Werner, Publica, Rosendahl, Jona, Kirsten, Holger, Hegyi, Eszter, Kovacs, Peter, Weiss, Frank Ulrich, Laumen, Helmut, Lichtner, Peter, Ruffert, Claudia, Chen, Jian min, Masson, Emmanuelle, Beer, Sebastian, Zimmer, Constantin, Seltsam, Katharina, Algül, Hana, Bühler, Florence, Bruno, Marco J, Bugert, Peter, Burkhardt, Ralph, Cavestro, GIULIA MARTINA, Cichoz lach, Halina, Farré, Antoni, Frank, Josef, Gambaro, Giovanni, Gimpfl, Sebastian, Grallert, Harald, Griesmann, Heidi, Grützmann, Robert, Hellerbrand, Clau, Hegyi, Péter, Hollenbach, Marcu, Iordache, Sevastitia, Jurkowska, Grazyna, Keim, Volker, Kiefer, Falk, Krug, Sebastian, Landt, Olfert, Leo, Milena Di, Lerch, Markus M, Lévy, Philippe, Löffler, Marku, Löhr, Matthia, Ludwig, Maren, Macek, Milan, Malats, Nuria, Malecka panas, Ewa, Malerba, Giovanni, Mann, Karl, Mayerle, Julia, Mohr, Sonja, Te Morsche, Rene H. M, Motyka, Marie, Mueller, Sebastian, Müller, Thoma, Nöthen, Markus M, Pedrazzoli, Sergio, Pereira, Stephen P, Peters, Annette, Pfützer, Roland, Real, Francisco X, Rebours, Vinciane, Ridinger, Monika, Rietschel, Marcella, Rösmann, Eva, Saftoiu, Adrian, Schneider, Alexander, Schulz, Hans ulrich, Soranzo, Nicole, Soyka, Michael, Simon, Peter, Skipworth, Jame, Stickel, Felix, Strauch, Konstantin, Stumvoll, Michael, Testoni, PIER ALBERTO, Tönjes, Anke, Werner, Lena, Werner, Jen, Wodarz, Norbert, Ziegler, Martin, Masamune, Atsushi, Mössner, Joachim, Férec, Claude, Michl, Patrick, Joost, P. H. Drenth, Witt, Heiko, Scholz, Marku, Sahin tóth, Miklós, and Gastroenterology & Hepatology
- Subjects
0301 basic medicine ,Linkage disequilibrium ,medicine.medical_specialty ,Settore MED/12 - GASTROENTEROLOGIA ,Population ,Genome Wide Association Study ,Chronic Pancreatitis ,Genetic Rearrangement ,Locus (genetics) ,Single-nucleotide polymorphism ,Genome-wide association study ,Biology ,Gastroenterology ,chronic pancreatitis ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,Internal medicine ,Genetic predisposition ,medicine ,Allele ,education ,Genetics ,education.field_of_study ,medicine.disease ,ddc ,genetic rearrangement ,Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] ,030104 developmental biology ,Genome wide association study ,Pancreatitis ,chronic pancreatiti ,Chronic pancreatitis ,Genetic rearrangement - Abstract
ObjectiveAlcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus.Design1959 European alcoholic CP patients and population-based controls from the KORA, LIFE and INCIPE studies (n=4708) as well as chronic alcoholics from the GESGA consortium (n=1332) were screened with Illumina technology. For replication, three European cohorts comprising 1650 patients with non-alcoholic CP and 6695 controls originating from the same countries were used.ResultsWe replicated previously reported risk loci CLDN2-MORC4, CTRC, PRSS1-PRSS2 and SPINK1 in alcoholic CP patients. We identified CTRB1-CTRB2 (chymotrypsin B1 and B2) as a new risk locus with lead single-nucleotide polymorphism (SNP) rs8055167 (OR 1.35, 95% CI 1.23 to 1.6). We found that a 16.6 kb inversion in the CTRB1-CTRB2 locus was in linkage disequilibrium with the CP-associated SNPs and was best tagged by rs8048956. The association was replicated in three independent European non-alcoholic CP cohorts of 1650 patients and 6695 controls (OR 1.62, 95% CI 1.42 to 1.86). The inversion changes the expression ratio of the CTRB1 and CTRB2 isoforms and thereby affects protective trypsinogen degradation and ultimately pancreatitis risk.ConclusionAn inversion in the CTRB1-CTRB2 locus modifies risk for alcoholic and non-alcoholic CP indicating that common pathomechanisms are involved in these inflammatory disorders.
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- 2018
19. Flexible endoscopic treatment for Zenker's diverticulum: from the lumen to the third space.
- Author
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Maselli R, Spadaccini M, Cappello A, Vespa E, Leo MD, Fugazza A, Pellegatta G, Galtieri PA, Ferrara EC, Anderloni A, Carrara S, Chandrasekar VT, Belletrutti PJ, and Repici A
- Abstract
Zenker's diverticulum (ZD) is a rare outpouching of the esophageal mucosa herniating posteriorly through Killian's triangle. Treatments of ZD aim to dissect the cricopharyngeal muscle to remove the underlying dysfunctional condition. In the last decade, a septotomy performed utilizing a flexible endoscope has been reported as a safe and effective alternative to both open surgery and rigid endoscopic diverticulotomy. More recently, Li et al described a novel endoscopic technique to treat ZD, named "submucosal tunneling endoscopic septum division", inspired by the peroral endoscopic myotomy (POEM) procedure developed for achalasia. Subsequently, the term Z-POEM was introduced and has become the most frequently used acronym to define the tunneling technique for ZD. This article describes the flexible therapeutic endoscopic strategies for treating ZD, including the novel third space approach, which seems to show promising potential in terms of clinical efficacy and safety., Competing Interests: Conflict of Interest: None, (Copyright: © 2021 Hellenic Society of Gastroenterology.)
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- 2021
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20. What should be known prior to performing EUS exams? (Part II).
- Author
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Dietrich CF, Arcidiacono PG, Braden B, Burmeister S, Carrara S, Cui X, Leo MD, Dong Y, Fusaroli P, Gottschalk U, Healey AJ, Hocke M, Hollerbach S, Garcia JI, Ignee A, Jürgensen C, Kahaleh M, Kitano M, Kunda R, Larghi A, Möller K, Napoleon B, Oppong KW, Petrone MC, Saftoiu A, Puri R, Sahai AV, Santo E, Sharma M, Soweid A, Sun S, Bun Teoh AY, Vilmann P, Seifert H, and Jenssen C
- Abstract
In "What should be known prior to performing EUS exams, Part I," the authors discussed the need for clinical information and whether other imaging modalities are required before embarking EUS examinations. Herewith, we present part II which addresses some (technical) controversies how EUS is performed and discuss from different points of view providing the relevant evidence as available. (1) Does equipment design influence the complication rate? (2) Should we have a standardized screen orientation? (3) Radial EUS versus longitudinal (linear) EUS. (4) Should we search for incidental findings using EUS?, Competing Interests: None
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- 2019
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21. Endoscopic ultrasound-guided transmural drainage by cautery-tipped lumen-apposing metal stent: exploring the possible indications.
- Author
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Anderloni A, Leo MD, Carrara S, Fugazza A, Maselli R, Buda A, Amato A, Auriemma F, and Repici A
- Abstract
Background: The recently introduced Hot AXIOS™ system for endoscopic ultrasound (EUS)-guided transenteric drainage has the potential to change interventional endoscopy significantly. The aim of our study was to assess the effectiveness and safety of this new type of lumen-apposing metal stent (LAMS) with cautery system for pancreatic collection, and gallbladder and biliary tree drainage., Methods: We retrospectively reviewed consecutive patients undergoing EUS-guided drainage by LAMS with cautery system in a tertiary-care academic medical center between March 2014 and March 2017. All patients were included in our prospectively maintained institutional EUS database. The main outcome measures were technical success, clinical effectiveness, and adverse events., Results: A total of 45 patients (20 men, mean age 69.6 years) underwent LAMS placement. Indications were pancreatic fluid collections (19 patients, 42.2%), acute cholecystitis (10 patients, 22.2%), and biliary drainage (16 patients, 35.5%). Technical success was achieved in all patients except one (97.7%). Clinical success was achieved in 86.4% (38/44) of cases and adverse events occurred in 5 (11.4%) of patients., Conclusions: In our experience, EUS-guided LAMS placement performed by expert endoscopists was feasible and effective in the endoscopic management of pancreatic fluid collection, and biliary and gallbladder drainage. Optimization of transmural drainage by new dedicated devices could improve efficacy and safety in appropriately selected patients., Competing Interests: Conflict of Interest: None
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- 2018
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22. Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.
- Author
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Rosendahl J, Kirsten H, Hegyi E, Kovacs P, Weiss FU, Laumen H, Lichtner P, Ruffert C, Chen JM, Masson E, Beer S, Zimmer C, Seltsam K, Algül H, Bühler F, Bruno MJ, Bugert P, Burkhardt R, Cavestro GM, Cichoz-Lach H, Farré A, Frank J, Gambaro G, Gimpfl S, Grallert H, Griesmann H, Grützmann R, Hellerbrand C, Hegyi P, Hollenbach M, Iordache S, Jurkowska G, Keim V, Kiefer F, Krug S, Landt O, Leo MD, Lerch MM, Lévy P, Löffler M, Löhr M, Ludwig M, Macek M, Malats N, Malecka-Panas E, Malerba G, Mann K, Mayerle J, Mohr S, Te Morsche RHM, Motyka M, Mueller S, Müller T, Nöthen MM, Pedrazzoli S, Pereira SP, Peters A, Pfützer R, Real FX, Rebours V, Ridinger M, Rietschel M, Rösmann E, Saftoiu A, Schneider A, Schulz HU, Soranzo N, Soyka M, Simon P, Skipworth J, Stickel F, Strauch K, Stumvoll M, Testoni PA, Tönjes A, Werner L, Werner J, Wodarz N, Ziegler M, Masamune A, Mössner J, Férec C, Michl P, P H Drenth J, Witt H, Scholz M, and Sahin-Tóth M
- Subjects
- Adult, Aged, Europe epidemiology, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Chymotrypsin genetics, Pancreatitis, Alcoholic epidemiology, Pancreatitis, Alcoholic genetics
- Abstract
Objective: Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus., Design: 1959 European alcoholic CP patients and population-based controls from the KORA, LIFE and INCIPE studies (n=4708) as well as chronic alcoholics from the GESGA consortium (n=1332) were screened with Illumina technology. For replication, three European cohorts comprising 1650 patients with non-alcoholic CP and 6695 controls originating from the same countries were used., Results: We replicated previously reported risk loci CLDN2-MORC4 , CTRC , PRSS1-PRSS2 and SPINK1 in alcoholic CP patients. We identified CTRB1-CTRB2 (chymotrypsin B1 and B2) as a new risk locus with lead single-nucleotide polymorphism (SNP) rs8055167 (OR 1.35, 95% CI 1.23 to 1.6). We found that a 16.6 kb inversion in the CTRB1-CTRB2 locus was in linkage disequilibrium with the CP-associated SNPs and was best tagged by rs8048956 . The association was replicated in three independent European non-alcoholic CP cohorts of 1650 patients and 6695 controls (OR 1.62, 95% CI 1.42 to 1.86). The inversion changes the expression ratio of the CTRB1 and CTRB2 isoforms and thereby affects protective trypsinogen degradation and ultimately pancreatitis risk., Conclusion: An inversion in the CTRB1-CTRB2 locus modifies risk for alcoholic and non-alcoholic CP indicating that common pathomechanisms are involved in these inflammatory disorders., Competing Interests: Competing interests: None declared., (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)
- Published
- 2018
- Full Text
- View/download PDF
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