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4. Eighth annual meeting of the European Association for the Study of Diabetes: Madrid, Spain September, 6–8, 1972

Author

Alberti, K. G. M. M., Darley, J., Emerson, Pauline M., Hockaday, T. D. R., Amherdt, M., Like, A. A., Blondel, B., Marliss, B., Wollheim, C., Orci, L., Andersen, O. Ortved, Andersson, Arne, Antonini, F. M., Fumagalli, C., Petruzzi, E., Bertini, G., Mori, S., Tinti, P., Ashcroft, S. J. H., Weerasinghe, L. C. C., Randle, P. J., Assan, R., Slusher, N., Guy-Grand, B., Girard, F., Soufflet, E., Attali, J. R., Ballerio, G., Boillot, J., Atkins, T., Matty, A. J., Bailey, C. J., Aynsley-Green, A., Bloom, S. R., Bacchus, R. A., Meade, L. G., London, D. R., Balant, L., Zahnd, G., Petitpierre, B., Fabre, J., Balasse, E. O., Neef, M. A., Barta, L., Brooser, G., Molnar, Maria, Bataille, D. P., Freychet, P., Kitabgi, P., Rosselin, G. E., Berne, Christian, Beyer, J., Cordes, U., Sell, G., Rosak, C., Schöffling, K., Birkner, B., Henner, J., Wagner, P., Erhardt, F., Dieterle, P., Bloom, S. R., Vaughan, N. J. A., Edwards, A. V., Boquist, L., Brand, I., Söling, H. D., Brandenburg, D., Gliemann, J., Ooms, H. A., Puls, W., Wollmer, A., Camerini-Davalos, R. A., Bloodworth, Jr., J. M. B., Limburg, B., Oppermann, W., Campbell, A. K., Siddle, K., Cañadell, J. M., Barraquer, J., Muiños, A., Heredia, C. D., Castillo-Olivares, J., Guijo, J., Pallardo, L. F., Cerasi, E., Efendić, S., Luft, R., Cerasi, E., Wahren, J., Luft, R., Felig, P., Christensen, Niels Juel, Christiansen, A. H., Vølund, A., Connon, J. J., Trimble, E., Copinschi, G., Leclercq, R., Bruno, O. D., Cordes, U., Sell, G., Beyer, J., Haupt, E., Schöffling, K., Creutzfeldt, C., Track, N. S., Cuendet, G. S., Wollheim, C. B., Cameron, D. P., Balant, L., Stauffacher, W., Marliss, E. B., Czyzyk, A., Lao, B., Bartosiewicz, W., Szczepanik, Z., De Nobel, E., Laar, A. Van't, Koene, R. A. P., Benraad, Th. J., Dietze, G., Hepp, K. D., Wickmayr, M., Mehnert, H., Dixon, K., Exon, P. D., Hughes, H. R., Jones, D. W., Elkeles, R. S., Exon, P. D., Dixon, K., FitzGerald, M. G., Malins, J. M., Falorni, A., Massi-Benedetti, F., Gallo, G., Maffei, S., Fedele, D., Tiengo, A., Muggeo, M., Fabris, P., Crepaldi, G., Federlin, K., Helmke, K., Slijepčević, M., Pfeiffer, E. F., Felber, J. P., Oulès, J., Schindler, Ch., Chabot, V., Fernandez-Cruz, Jr., A., Catalán, E., Otero, M. Luque, Hermida, O. Garcia, Otero, M. Luque, Catalán, E., Flatt, J. P., Blackburn, G., Randers, G., Förster, H., Hoos, I, Lerche, D., Förster, H., Hoos, I., Matthäus, M., Franckson, J. R. M., Ooms, H. A., Frerichs, H., Daweke, H., Gries, F., Grüneklee, D., Hessing, J., Jahnke, K., Keup, U., Miss, H., Otto, H., Puls, W., Schmidt, D., Zumfelde, C., Funcke, H. v., Löffler, G., Wieland, O., Galton, D. J., Guttman, R., Gazzola, G. C., Franchi, R., Ronchi, P., Saibene, V., Guidotti, G. G., Gligore, V., Hîncu, N., Tecuceanu, Rodica, Goberna, R., Garcia-Albertos, F., Tamarit-Rodriguez, J., del Rio, E., Roca, R., Gomez-Acebo, José, Creco, A. V., Fedeli, G., Ghirlanda, G., Fenici, R., Lucente, M., Gutman, A., Agam, G., Nahas, N., Cazalis, P., Gylfe, E., Hellman, B., Hadden, D. R., Connolly, J. H., Montgomery, D. A. D., Weaver, J. A., Hellerström, Claes, Howell, Simon, Andersson, Arne, Edwards, John, Sehlin, J., Täljedal, I. -B., Heptner, W., Neubauer, H. B., Herchuelz, A., Pipeleers, D. G., Malaisse, W. J., Herrera, E., Montoya, Eladio, Hommel, H., Fischer, IT., Schmid, B., Fiedler, H., Bibergeil, H., Iversen, J., Iynedjian, P. B., Peters, G., Jacquemin, C., Lambert, B., Sutter, B. Ch. J., Jakob, A., Zapf, J., Froesch, E. R., Jansen, F. K., Freytag, G., Herberg, L., Jarrett, R. J., Baker, I. A., Jarrousse, C., Rancon, F., Rosselin, G. E., Job, D., Tchobroutsky, G., Eschwege, E., Guyot-Argenton, C., Aubry, J. P., Déret, M., Karman, H., Mialhe, P., Kissebah, A., Tulloch, B., Fraser, Russell, Kissebah, A., Tulloch, B., Vydelingum, N., Fraser, Russell, Kissing, J., Raptis, S., Dollinger, H., Faulhaber, J., Rothenbuchner, G., Pfeiffer, E. F., Kleineke, J., Sauer, H., Söling, H. D., Kloeze, J., Kohner, Eva M., Sutcliffe, Barbara A., Tudball, M., Dollery, C. T., Korp, W., Neubert, J., Bruneder, H., Lenhardt, A., Levett, R. E., Koschinsky, T., Gries, F. A., Landgraf-Leurs, M. M. C., Landgraf, R., Hörl, R., Langslow, D. R., Laube, H., Fussgänger, R., Mayer, R., Pfeiffer, E. F., Laube, H., Fussgänger, R., Klör, H., Pfeiffer, E. F., Lázaro, E., Leclercq-Meyer, V., Marchand, J. J., Malaisse, W., Ledet, Thomas, Lefébvre, P. J., Luyckx, A. S., Le Marchand, Y., Assimacopoulos, F., Singh, A., Amherdt, M., Rouiller, Ch., Jeanrenaud, B., Lenti, G., Frezzotti, R., Angotzi, G., Bardelli, A. M., Pagano, G., Basetti-Sani, A., Galli, M., Lernmark, Å., Fex, G., Lindsay, D. G., Loge, O., Lopez-Quijada, C., Chiva, L., Rodriguez-Lopez, M., Loten, E. G., Loubatières, A. L., Loubatières-Mariani, M. M., Ribes, G., Chapal, J., Lubetzki, J., Duprey, J., Sambourg, Cl., Lefebvre, P. J., Maier, V., Hinz, M., Schatz, H., Nierle, C., Pfeiffer, E. F., Malaisse, W. J., Pipeleers, D. G., Malaisse-Lagae, F., Orci, L., Malaisse-Lagae, F., Amherdt, M., Ravazzola, M., Stauffacher, W., Orci, L., Renold, A. E., Manzano, P., Rojas-Hidalgo, E., Marco, J., Diaz-Fierros, D., Calle, C., Roman, D., Villanueva, M. L., Valverde, I., Marliss, E. B., Wollheim, C. B., Blondel, B., Orci, L., Like, A., Amherdt, M., Stauffacher, W., Massi-Benedetti, F., Luycks, A. L., Fracassini, F., Lefebvre, P. J., Falorni, A., Menzel, R., Michaelis, D., Neumann, I., Bibergeil, H., Schulz, B., Wilke, W., Wulfert, P., Krämer, K., Menzinger, G., Fallucca, F., Tamburrano, F., Carratu', R., Andreani, D., Metzger, P., Franken, P., Balasse, E. O., Michael, R., Hildmann, W., Jutzi, E., Michl, J., Fankhauser, S., Schlichtkrull, J., Mirouze, J., Orsetti, A., Vierne, Y., Arnoux, N., Mølsted-Pederson, L., Tygstrup, Inge, Villumsen, Åge L., Pedersen, Jørgen, Montague, W., Howell, S. L., Moody, A. J., Agerbak, G. S., Sundby, F., Muggeo, M., Crepaldi, G., Fedele, D., Baritussio, A., Naeser, Peter, Navalesi, R., Pilo, A., Lenzi, S., Cecchetti, P., Corsini, G., Donato, L., Nerup, J., Andersen, O. Ortved, Bendixen, G., Egeberg, J., Poulsen, J. E., Nielsen, J. Høiriis, Hansen, F. Mølgaard, Gliemann, J., Niki, A., Niki, H., Koide, T., Lin, B. J., Nikkels, R. E., Terpstra, J., Gay, A., Oakman, R. H., Lazarus, Norman R., Orci, L., Amherdt, M., Stauffacher, W., Like, A. A., Rouiller, C., Renold, A. E., Malaisse-Lagae, F., Ravazzola, M., Ostman, J., Backman, L., Cerasi, E., Luft, R., Hallberg, D., Ostrowski, K., Panten, U., Christians, J., Parving, H. -H., Rasmussen, S. Munkgaard, Marichal, M., Platilovà, H., Dufek, M., Konopàsek, E., Pozuelo, V., Tamarit, J., Suner, A., Castell, C., Pruett, E. D. R., Maehlum, S., Raptis, S., Grebe, B., Chrissiku, M., Rothenbuchner, G., Müller, R., Hinze, H. J., Pfeiffer, E. F., Reinauer, H., Müller-Ruchholtz, E. R., Rietzler, X., Passa, P., Canivet, J., Schatz, H., Otto, J., Hinz, M., Maier, V., Nierle, C., Behrens, G., Bücher, T., Pfeiffer, E. F., Schlumpf, U., Morell, B., Zingg, A., Schönborn, J., Westphal, P., Panten, U., Bloom, G. D., Idahl, L. -A., Lernmark, A., Söderberg, M., Rios, M. Serrano, Hawkins, F. G., Escobar, F., Mato, J. M., Larrodera, L., de Oya, M., Rodriguez-Miñon, J. L., Shafrir, E., Gutman, A., Sitbon, G., Mialhe, P., Skrabalo, Z., Panajatović, N., Papić, Z., Posinovec, J., Stavljenić, A., Lipovac, V., Aganović, I., Soler, N. G., Bennett, M. A., Söling, H. D., Peters, H., Janson, G., Sönksen, P. H., Srivastava, M. C., Tompkins, C. V., Nabarro, J. D. N., Sørensen, N. Schwartz, Ladefoged, K., Wildenhoff, K. E., Sorge, F., Diehl, H. -J., Hoffmann, H., Schwartzkopff, W., Standl, E., Kolb, H., Standl, A., Mehnert, H., Sutherland, H. W., Stowers, J. M., Whetham, J. C. G., Sutter, B. C. J., Billaudel, B., Sutter, B. Ch. J., Sutter-Dub, M. T., Leclercq, R., Jacquot, R., Täljedal, I. B., Tamarit, J., Tamarit-Rodriguez, J., Goberna, R., Gobema, R., Tamás, Jr., Gy., Baranyi, Éva, Baranyi, A., Radvanyi, A., Tatoń, J., Hinek, A., Wiśniewska, A., Tattersall, R. B., Pyke, D. A., Terpstra, J., Slot, J. Bruins, Sande, P. L. M. v. d., Radder, J. K., Waldeok, K. J. J., Muijden, R. C. P. A. v., Tiengo, A., Assan, R., Frerichs, H., Creutzfeldt, W., Turner, D. S., Baker, R. W., Gent, W. G. L., Shabaan, A., Marks, V., Young, D. A. B., Vague, Ph., Heim, H., Laval, C. Martin, Vegezzi, M., Campo, C.Di, Rahamandridona, G., Garron, D., Heyraud, B., Vague, J., Valverde, I., Villanueva, M. L., Lozano, I., Diaz-Fierros, M., Marco, J., Van Assche, F. A., Gepts, W., Van Obberghen, E., Somers, G., Devis, G., Vaughan, G. D., Malaisse-Lagae, F., Orci, L., Malaisse, W. J., Veleminsky, J., Spirova, E., Waldhäusl, W., Frisch, H., Haydl, H., Weiss, L., Löffler, G., Wieland, O., Willms, B., Deuticke, U., Wollheim, C. B., Marliss, E. B., Blondel, B., Orci, L., Like, A., Renold, A. E., Zrůstová, M., and Roštlapil, J.

Published
1973
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5. Second Annual Meeting of the European Association for the Study of Diabetes abstracts: Second part Aarhus, Denmark, July 6–8, 1966

Author

Ireland, J. T., Patnaik, B. K., Duncan, L. J. P., Jaksic, Z., Jakob, A., Lauper, N., Flury, R., Labhart, A., Froesch, E. R., Jarrett, R. J., Keen, H., Track, N., Jervell, J., Vallance-Owen, J., Bajaj, J. S., Jørgensen, K., Binder, C., Nielsen, Aa. V., Kammerer, L., Bretán, M., Nemsánszky, L., Jakab, L., Virág, III, S., Virag, S., Keat, E., Kerp, L., Kieling, F., Steinhilber, S., Keep, L., Knick, B., Korec, R., Korp, W., Lalouschek, L., Levett, R. E., Summer, K., Krentz, K., Kristensen, M., Kuhlencordt, Friedrich, Kuhlencordt, F., Kühnau, Jr., J., Meyer, H. -W., Lambert, A. E., Hoet, J. J., Lambotte, L., Shoemaker, W. C., Lefebvre, P., Lenti, G., Pellegrini, A., Pagano, G., Brotzu, M. V., Sirigu, F., Lestradet, H., Deschamps, I., Liebermeister, H., Rüenauver, R., Grüneklee, D., Schilling, W., Jahnke, K., Daweke, H., Löffler, G., Weinges, K. F., Lopez-Quijada, C., R-Candela, J. L., Loubatieres, A., Mariani, M. M., Alric, R., Lowy, C., Rubenstein, A. H., Weight, A. D., Martin, T. J., Russell, T., Luft, R., Madison, L., Cerasi, E., von Euler, U. S., Margolis, A., Bugala, I., Marasek, L., Marks, Vincent, Howorth, P. J. N., Samols, Ellis, Greenwood, F. C., Mazzi, C., Melani, F., Lawecki, J., Bartelt, K. M., Pfeiffer, E. F., Menzinger, G., Fallucca, F., Aliberti, L., Andreani, D., Meyer, U. A., Miki, E., Elliott P., Milani R., Bianchessi, M., Mirouze, J., Cartry, E., Saade, F., Jaffiol, C., Montenero, P., Denatone, P., Donatone, E., Ørskov, H., Östman, J., Øye, I., Sinclair, D., Pallardo, L. F., Cartillo-Olivares, J., Guijo, J., Garrido, J. M. Garcia, Castillo-Olivares, J., Matute, J. L., Pathe, G., Comtesse, G., Polge, U., Contesse, G., Pavel, I., Pieptes, R., Pedebsen, Jørgen, Pedersen, L. Mølsted, Jørgensen, K. R., Penchev, I., Piancino, G., Martini, P. P., Cravetto, C. A., Pieri, A., Scarpelli, P. T., Pihl, E., Falkmer, S., Pometta, D., Tatot, J., Rees, S. B., Kuwabara, T., Taton, J., Rees, S. B., Poulsen, J. E., Werner, A. U., Pozza, G., Ghidoni, A., Sanesi, E., Quinto, P., Flamigni, O., Tirelli, R., Flamingni, C., Rafaelsen, Ole J., Lyngsoe, J., Deckert, T., Reske-Nielsen, Edith, Lundbæk, Knud, Roderiguez-Minon, J. L., Rosell-Perez, M., Hedeskov, C. J., Esmann, V., Rosselin, G., Tchobroutsky, G., Freychet, P., Assan, R., Derot, M., Rudas, Barbara, Liebermeisteb, H., Salinas, Matilde, R-Candela, J. L., Samols, E., Tyler, J., Marks, V., Schliack, V., Skovborg, F., Schlichtkrull, J., Ditzel, J., Skrabalo, Z., Stavljenic, A., Crepinko, I., Dimitrov, N., Sönksen, P. H., Ellis, J. P., Greenwood, F., Nabarro, J. D. N., Söling, H. D., Zahlten, R., Willms, B., Stauffacher, W., Jeanrenaud, B., Sutter, B. Ch. J., Meyer, V., Mialhe, P., Thomas, K., de Gasparo, M., Toussaint, D., Gepts, W., Pickering, G. W., Fraser, J. A., Travia, L., Dalla Torre, L., Forcina, G., Gandolfo, L., Turner, D. S., McIntyre, N., Tutin, M., Rousselie, F., Rathery, M., Borna, H., Bour, H., Unger, R. H., Recant, L., McGavran, M., Siperstein, M. D., Vague, Ph., Depieds, R., Boeuf, G., Codaccioni, J. L., Vague, J., Vague, P., Vitelli, A., Segre, G., Martino, P., Saiani, A., Martini, P. F., Saisni, A., Martini, P. F., Vuletic, S., Wahl, P., Kettnaker, W., Walaas, W., Walaas, O., Wildenhoff, K. E., Dalsager, H., Schwartz, N., Böttcher, M., Sakomoto, N., Söling, H. D., Winand, J., Furnelle, J., Christophe, J., Woenckhaus, J. W., Günter, D., Yde, H., Young, D. A. B., Benson, B., Zahnd, G. R., Luyks, A., Zaragoza, N., and Felber, J. P.

Published
1966
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11. Effects of a xanthine derivative (BL 191) on insulin secretion in normal man.

Author

Lenti, G., Pagano, G., Angotzi, G., Basetti Sani, A., and Diana, A.

Abstract

A xanthine derivative, named BL-191, was administered iv in 8 healthy volunteers alone and in association with glucose (0.33 g/kg body weight iv) or glybenclamide (1 mg iv). BL-191 was infused iv at a constant rate in a dose of 200 mg during 45 minutes. Blood glucose, free fatty acids and immunoreactive insulin were measured during one hour. It was impossible to demonstrate neither a direct effect nor an enhancement of insulin secretion during drug administration; in another experiment (treatment F) a higher dosage of BL-191 (100 mg as a priming dose + 200 mg as infusion dose) was likely ineffective. It appears that some difference in insulin response may be present in the single subject (not evident in the mean), indicating a difference in the β-cell cAMP-system sensitivity in individuals. These negative results allow some considerations on the importance of the β-cell cAMP-system in healthy human beings. [ABSTRACT FROM AUTHOR]

Published
1976
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18. Ricerche Sperimentali Sull'effetto Anticellulare di Alcune Associazioni di Antimitotici su Elementi Proliferanti in Vitro

Author

Musolino G, Girardi F, Tortarolo E, and Lenti G

Subjects
Drug, Deacetylcolchicine, Cancer Research, Oncology, Chemistry, media_common.quotation_subject, Cytostatic agents, Cytotoxic T cell, General Medicine, Pharmacology, Experimental research, In vitro, media_common
Abstract

The action of some associations of cytostatic agents on « in vitro » embryonic cells are studied: chloramine, deacetylcolchicine and 6-mercapto-purine added with hydrocortisone, and 6-mercapto-purine plus chloramine. The effective doses of each drug were always remarkably lower than those wich were found to have the minimal action in previous researches. It is so demonstrated that this association potentiates the activity of the single drugs. The enhancement varies as for the type and intensity in the different experimented associations. The possibility of a therapeutical application of the cytotoxic combinations is discussed.

Published
1957
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19. Ricerche Sperimentali Sul Metabolismo Di Cellule Neoplastiche Ceppo K.B. Coltivate in Vitro

Author

Pellegrini A, Tortarolo E, and Lenti G

Subjects
Cancer Research, Oncology, Chemistry, General Medicine
Abstract

The authors have investigated the respiration and glycolytic activity of human cancer cells (strain K B) « in vitro ». A low oxygen uptake, an increased aerobic glycolysis and no striking increase of anaerobic glycolysis have been observed. The results are briefly discussed.

Published
1958
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20. Modificazioni Metaboliche Di Elementi Umani Normali Coltivati « in Vitro » Indotte Da Frazione Cellulare Microsomiale Del Ceppo Neoplastico KB

Author

Pagano Pg, Tortarolo E, Lenti G, and Pellegrini A

Subjects
Genetics, Cancer Research, Oncology, Strain (chemistry), Biochemistry, Kidney metabolism, General Medicine, Biology, In vitro
Abstract

The metabolism of normal renal cells cultivated «in vitro» undergoes several changes following contact with a microsomal fraction of neoplastic cell of KB strain. This new functional situation is characterised by a decreased O2 consumption and an increased aerobic glicolysis with a diminution of the oxydation/glicolysis ratio. Microsomal fraction of normal renal cells fails to induce any significant change.

Published
1961
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21. Modificazioni Metaboliche Di Elementi Umani Normali Coltivati « in Vitro » Indotte Da Frazione Cellulare Microsomiale Del Ceppo Neoplastico KB

Author

Lenti, G., Tortarolo, E., Pellegrini, A., and Pagano, P. G.

Abstract

The metabolism of normal renal cells cultivated «in vitro» undergoes several changes following contact with a microsomal fraction of neoplastic cell of KB strain. This new functional situation is characterised by a decreased O2consumption and an increased aerobic glicolysis with a diminution of the oxydation/glicolysis ratio. Microsomal fraction of normal renal cells fails to induce any significant change.

Published
1961
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22. Ricerche Sperimentali Sull'effetto Anticellulare di Alcune Associazioni di Antimitotici su Elementi Proliferanti in Vitro

Author

Lenti, G., Tortarolo, E., Musolino, G., and Girardi, F.

Abstract

The action of some associations of cytostatic agents on « in vitro » embryonic cells are studied: chloramine, deacetylcolchicine and 6-mercapto-purine added with hydrocortisone, and 6-mercapto-purine plus chloramine.The effective doses of each drug were always remarkably lower than those wich were found to have the minimal action in previous researches.It is so demonstrated that this association potentiates the activity of the single drugs. The enhancement varies as for the type and intensity in the different experimented associations. The possibility of a therapeutical application of the cytotoxic combinations is discussed.

Published
1957
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24. Pathogenetic aspects of cholemic nephropathy

Author

Lenti G, Emanuelli G, Gatti G, Cestonaro G, Calcamuggi G, Anfossi G, Battaglia G, Giovanni Camussi, and Robecchi A

Subjects
Bile Acids and Salts, Cholestasis, Liver Diseases, Animals, Bile, Humans, Immunoglobulins, Kidney Diseases, Acute Kidney Injury, Bile Pigments, Kidney
Published
1978

26. [Changes in erythrocyte deformability following changes in oxido-reductive metabolism in diabetes mellitus]

Author

Ghigo, Dario Antonio, Bosia, Amalia, Pagani, A., Pescarmona, Gianpiero, Pagano, G., and Lenti, G.

Subjects
Adult, Osmotic Fragility, Erythrocytes, Diabetes Mellitus, Humans, Sorbitol, Ultrafiltration, Middle Aged, Glutathione, Oxidation-Reduction, NADP, Aged
Abstract

The enhanced sorbitol synthesis in diabetic red blood cells can lead to a depletion of NADPH and, by limiting the amount of GSH produced in the glutathione-reductase step, can make the cell more susceptible to oxidant injury. Diabetic red blood cells have a shortened life span, as shown by the increase of creatine level. The osmotic resistance of diabetic erythrocytes was measured and the erythrocyte flexibility was studied using a filtration method in which the cells were forced, at a constant flow rate, through a polycarbonate membrane with 5-mu pores. The increased osmotic resistance and the impaired flexibility shown by diabetic red blood cells can be induced in normal cells by a treatment with SH-reagents (diamide). This points to a redox state-mediated decrease in deformability and survival of diabetic erythrocytes.

Published
1983

34. Insulin binding to isolated monocytes and adipocytes in the study of hypoglycemic subjects and in the follow-up of patients with insulinoma

Author

Bozzo, C., Carta, Q., Cassader, M., Lenti, G., Lorenzati, R., Masciola, P., Pagano, G., and MARIELLA TROVATI

Subjects
Adult, Male, Adolescent, Middle Aged, Adenoma, Islet Cell, Hypoglycemia, Monocytes, Receptor, Insulin, Pancreatic Neoplasms, Adipose Tissue, Humans, Insulin, Female, Insulinoma, Aged
Abstract

The present study was performed to see whether insulin receptor evaluation is useful as a diagnostic tool in the differential diagnosis of hypoglycemia. The receptor numbers and affinity constants of insulin binding to adipocytes isolated from subcutaneous tissue were determined in 5 metabolically healthy subjects, undergoing laparatomy for cholecystectomy, and in 4 patients undergoing surgery for insulinoma removal. The specific insulin binding to monocytes at physiological concentrations (1 ng/ml) was also determined in all these subjects, and in 6 patients with functional hypoglycemia. The study was repeated in insulinoma patients 7 days after surgery. Results show that insulinoma patients before tumor removal have greater than 50% fall in binding capacity on both monocytes and fat cells, in keeping with the down-regulation mechanism, whereas the values for patients with functional hypoglycemia are in the normal range. After surgery, the insulin binding to monocytes sharply increased, nearly to the lower level of the normal range when the insulinoma was removed; no change was observed when the tumor was not resected (case 3). Insulin receptor study may therefore be of diagnostic and prognostic assistance in the investigation of hypoglycemic syndromes.

Published
1983

36. Effects of a xanthine derivative (BL 191) on insulin secretion in normal man

Author

Diana A, Sani Ab, Angotzi G, Lenti G, and Gianfranco Pagano

Subjects
Adult, Blood Glucose, Male, medicine.medical_specialty, Derivative, Fatty Acids, Nonesterified, Body weight, chemistry.chemical_compound, Diabetes mellitus, Internal medicine, Insulin response, Glyburide, Insulin Secretion, Medicine, Humans, Insulin, Pharmacology (medical), Infusions, Parenteral, Insulin secretion, Pharmacology, Immunoreactive insulin, business.industry, Drug administration, General Medicine, Xanthine, medicine.disease, Endocrinology, Glucose, chemistry, Xanthines, business
Abstract

A xanthine derivative, named BL-191, was administered iv in 8 healthy volunteers alone and in association with glucose (0.33 g/kg body weight iv) or glybenclamide (1 mg iv). BL-191 was infused iv at a constant rate in a dose of 200 mg during 45 minutes. Blood glucose, free fatty acids and immunoreactive insulin were measured during one hour. It was impossible to demonstrate neither a direct effect nor an enhancement of insulin secretion during drug administration; in another experiment (treatment F) a higher dosage of BL-191 (100 mg as a priming dose + 200 mg as infusion dose) was likely ineffective. It appears that some difference in insulin response may be present in the single subject (not evident in the mean), indicating a difference in the beta-cell cAMP-system sensitivity in individuals. These negative results allow some considerations on the importance of the beta-cell cAMP-system in healthy human beings.

Published
1975

43. Developing a minimum data set for stroke patients assessment: The 'Protocollo di Minima per l'Ictus' (PMIC) as a starting point towards an Italian stroke registry

Author

Lenti G, Agosti M, Massucci M, Zampolini M, Stefano Paolucci, and Franceschini M

Subjects
Adult, Stroke, Outcome and Process Assessment, Health Care, Italy, Stroke Rehabilitation, Humans, Reproducibility of Results, Registries, Physical and Rehabilitation Medicine, Prognosis, Needs Assessment, Quality Indicators, Health Care
Abstract

The complex nature of stroke sequelae requires several assessment instruments to quantify correctly every residual symptom. As there was no general consensus on stroke evaluation among Italian Physiatrists, in 2004 the Italian Society of Physical Medicine and Rehabilitation and S. Lucia Foundation (a Scientific Institute for hospitalization and treatment) established a Project Group to propose a standardized assessment tool (''Protocollo di Minima per l'Ictus PMIC'') for acute, post-acute and community-living stroke patients. This tool aimed to be easy to use and comprehensive of all the elements necessary for accurately address the great range of different rehabilitation needs. The objective was to provide physiatrists with a standard assessment battery and to make prognostic factors available on large community samples.From end 2004 to early 2006, the Project Group examined literature data on stroke assessment, prognostic factors and outcome and selected the specific data elements to be included in a data collection tool.A consensus was reached on a ''minimum'' core set of data. This protocol was peer submitted in early 2006, to test the burden of data collection, and to allow modifications and adjustments. Specific forms (file to download) for data collection and database to be shared (a dedicated ''Client'' software) are now freely offered by the Project Group for data collection.PMIC is an evaluation procedure manageable in every-day practice and in every setting, a quick screening instrument that, given its large diffusion, can be expanded from a National Database into a National Rehabilitation Stroke Registry.

44. $K^+ → π^+ ν\overline{ν}$: first NA62 results

Author

Marchevski, Radoslav, Aliberti, R., Ambrosino, F., Ammendola, R., Angelucci, B., Antonelli, A., Anzivino, G., Arcidiacono, R., Barbanera, M., Biagioni, A., Bician, L., Biino, C., Bizzeti, A., Blazek, T., Bloch-Devaux, B., Bonaiuto, V., Boretto, M., Bragadireanu, M., Britton, D., Brizioli, F., Brunetti, M. B., Bryman, D., Bucci, F., Capussela, T., Ceccucci, A., Cenci, P., Cerny, V., Cerri, C., Checcucci, B., Conovaloff, A., Cooper, P., Gil, E. Cortina, Corvino, M., Costantini, F., Ramusino, A. Cotta, Coward, D., Agostini, J., Dainton, P., Dalpiaz, H., Danielsson, N., Simone, D. Di, Filippo, L., Lella, N. Di, Doble, B., Dobrich, F., Duval, V., Duk, J., Engelfried, T., Enik, N., Estrada-Tristan, V., Falaleev, R., Fantechi, V., Fascianelli, L., Federici, S., Fedotov, A., Filippi, M., Fiorini, J., Fry, J., Fu, A., Fucci, L., Fulton, E., Gamberini, L., Gatignon, G., Georgiev, G. S., Ghinescu, A., Gianoli, M., Giorgi, S., Giudici, F., Gonnella, E., Goudzovski, C., Graham, R., Guida, E., Gushchin, F., Hahn, H., Heath, T., Husek, O., Hutanu, D., Hutchcroft, L., Iacobuzio, E., Iacopini, E., Imbergamo, B., Jenninger, K., Kampf, V., Kekelidze, S., Kholodenko, G., Khoriauli, A., Khotyantsev, A., Kleimenova, A., Korotkova, M., Koval, V., Kozhuharov, Z., Kucerova, Y., Kudenko, J., Kunze, V., Kurochka, V., Kurshetsov, G., Lanfranchi, G., Lamanna, G., Latino, P., Laycock, C., Lazzeroni, M., Lenti, G., Lehmann, Miotto, Leonardi, E., Lichard, P., Litov, L., Lollini, R., Lomidze, D., Lonardo, A., Lubrano, P., Lupi, M., Lurkin, N., Madigozhin, D., Mannelli, I., Mannocchi, G., Mapelli, A., Marchetto, F., Marchevski, R., Martellotti, S., Massarotti, P., Massri, K., Maurice, E., Medvedeva, M., Mefodev, A., Menichetti, E., Migliore, E., Minucci, E., Mirra, M., Misheva, M., Molokanova, N., Moulson, M., Movchan, S., Napolitano, M., Neri, I., Newson, F., Norton, A., Noy, M., Numao, T., Obraztsov, V., Ostankov, A., Padolski, S., Page, R., Vito Palladino, Parkinson, C., Pedreschi, E., Pepe, M., Perrin-Terrin, M., Peruzzo, L., Petrov, P., Petrucci, F., Piandani, R., Piccini, M., Pinzino, J., Polenkevich, I., Pontisso, L., Potrebenikov, Yu, Protopopescu, D., Raggi, M., Romano, A., Rubin, P., Ruggiero, G., Ryjov, V., Salamon, A., Santoni, C., Saracino, G., Sargeni, F., Semenov, V., Sergi, A., Shaikhiev, A., Shkarovskiy, S., Soldi, D., Sougonyaev, V., Sozzi, M., Spadaro, T., Spinella, F., Sturgess, A., Swallow, J., Trilov, S., Valente, P., Velghe, B., Venditti, S., Vicini, P., Volpe, R., Vormstein, M., Wahl, H., Wanke, R., Wrona, B., Yushchenko, O., Zamkovsky, M., and Zinchenko, A.

45. Stroke and rehabilitation: Italian Cooperative Research (ICR2)

Author

Franceschini, M., Branchini, W., Rodolfo Brianti, Camillis, E., Ferrari, L., Galvagni, R., Lenti, G., Manca, M., Mayer, F., Molteni, F., Perdon, L., Procicchiani, D., Todeschini, E., Zaccala, M., Agosti, M., Casella, G., Celani, M. G., Citterio, A., Masucci, M., Spizzichino, L., Vallasciani, M., Recupero, E., Finocchiaro, F., Santagati, A., Greco, S., Longo, P., Comessatti, C., Taroni, B., Cosentino, E., Biondi, T., Mugelli, C., Maria Rossi, R., Serra, A., Bertoni, M., Meinecke, C., Fabbrini, S., Confalonieri, D., Ceruti, R., Fortina, C., Zaccaria, B., Meneghetti, S., Robuschi, K., Michelotti, V., Cavaldonati, A., Sandrini, G., Arrigo, A., Antenucci, R., Gandolfi, P., Gatta, G., Boschini, L., Dardani, M., Massucci, M., Braconi, A. R., Bortoluzzi, N., and Timar, J.

50. Emotion regulation, hope, and optimism during the third wave of the COVID-19 pandemic: The role of age and personality.

Author

Carbone E, Lenti G, Sella E, Moè A, and Borella E

Subjects
Young Adult, Humans, Aged, Pandemics, Emotions, Personality, Optimism, Emotional Regulation, COVID-19 epidemiology
Abstract

Aims: This study examined age-related differences between young and older adults' emotion regulation, hope, and optimism 1 year after the COVID-19 outbreak. Whether personality explained such outcomes was also examined., Method: A sample of 228 young adults and 161 older adults was interviewed in April-May 2021 to complete questionnaires assessing cognitive reappraisal (CR) and expressive suppression (ES) emotion regulation strategies use, optimism, hope (agency and pathways components), and personality traits., Results: Older adults reported greater CR and ES use, optimism, and hope-agency levels than young adults, whereas no age differences emerged for hope-pathway scores. Personality traits (more consistently emotional stability) contributed to explaining CR and ES use, and greater hopeful and optimistic dispositions., Conclusions: These findings confirm older adults' advantage in facing the emotional and psychological fallout of the COVID-19 pandemic in its third wave. They also underscore the importance of considering personality to depict individual profiles prone to experiencing long-term negative emotional/psychological consequences of emergencies as COVID-19., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Carbone et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Published
2024
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